                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
      BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
 
<120> METHODS OF IDENTIFYING EQUINE IMMUNE-MEDIATED MYOSITIS

<130> UCDVP144WO

<140> PCT/US2018/034438
<141> 2018-05-24

<150> 62/510,877
<151> 2017-05-25

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 1938
<212> PRT
<213> Equus caballus


<220>
<221> MOD_RES
<222> (320)..(320)
<223> Glu or Gly

<400> 1
Met Ser Ser Asp Gln Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Tyr 
1               5                   10                  15      


Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Ser Val Phe Val Ala Asp Pro Lys Glu Ser Phe Val 
        35                  40                  45              


Lys Ala Thr Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gly Ala Thr Val Thr Val Lys Glu Asp Gln Cys Phe Pro Met 
65                  70                  75                  80  


Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His 
                85                  90                  95      


Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Thr Ala Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu 
        195                 200                 205             


Glu Pro Thr Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Met Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Xaa 
305                 310                 315                 320 


Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Glu Ile Leu Gly Phe Thr Ser Asp Glu Arg Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Leu Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Gly Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Phe Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Glu Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Asp Lys Met Phe Leu Trp Met Val Ala Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Val Lys Gly Lys Pro 
                565                 570                 575     


Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn 
            580                 585                 590         


Ile Thr Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ser Val Lys Thr Leu Ala Leu Leu Phe 
    610                 615                 620                 


Ser Gly Pro Ala Ser Ala Asp Ala Glu Ala Gly Gly Lys Lys Gly Gly 
625                 630                 635                 640 


Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu 
                645                 650                 655     


Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe 
            660                 665                 670         


Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu 
        675                 680                 685             


His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly 
    690                 695                 700                 


Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala Asp 
705                 710                 715                 720 


Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu Gly 
                725                 730                 735     


Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser Ile 
            740                 745                 750         


Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe 
        755                 760                 765             


Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Asp Lys Leu 
    770                 775                 780                 


Ala Gln Ile Ile Thr Arg Thr Gln Ala Arg Cys Arg Gly Phe Leu Ala 
785                 790                 795                 800 


Arg Val Glu Tyr Gln Arg Met Val Glu Arg Arg Glu Ser Ile Phe Cys 
                805                 810                 815     


Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro Trp 
            820                 825                 830         


Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr 
        835                 840                 845             


Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys Glu 
    850                 855                 860                 


Ser Leu Ala Lys Ala Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Met 
865                 870                 875                 880 


Val Ala Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala 
                885                 890                 895     


Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile 
            900                 905                 910         


Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Ala Thr Glu Arg 
        915                 920                 925             


Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg 
    930                 935                 940                 


Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu 
945                 950                 955                 960 


Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn 
                965                 970                 975     


Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr Ile 
            980                 985                 990         


Ala Lys Leu Thr Lys Glu Lys Lys  Ala Leu Gln Glu Ala  His Gln Gln 
        995                 1000                 1005             


Thr Leu  Asp Asp Leu Gln Ala  Glu Glu Asp Lys Val  Asn Thr Leu 
    1010                 1015                 1020             


Thr Lys  Ala Lys Thr Lys Leu  Glu Gln Gln Val Asp  Asp Leu Glu 
    1025                 1030                 1035             


Gly Ser  Leu Glu Gln Glu Lys  Lys Leu Arg Met Asp  Leu Glu Arg 
    1040                 1045                 1050             


Ala Lys  Arg Lys Leu Glu Gly  Asp Leu Lys Leu Ala  Gln Glu Ser 
    1055                 1060                 1065             


Thr Met  Asp Ile Glu Asn Asp  Lys Gln Gln Leu Asp  Glu Lys Leu 
    1070                 1075                 1080             


Lys Lys  Lys Glu Phe Glu Met  Ser Asn Leu Gln Ser  Lys Ile Glu 
    1085                 1090                 1095             


Asp Glu  Gln Ala Leu Ala Met  Gln Leu Gln Lys Lys  Ile Lys Glu 
    1100                 1105                 1110             


Leu Gln  Ala Arg Ile Glu Glu  Leu Glu Glu Glu Ile  Glu Ala Glu 
    1115                 1120                 1125             


Arg Ala  Ser Arg Ala Lys Ala  Glu Lys Gln Arg Ser  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Leu Glu Glu Ile Ser  Glu Arg Leu Glu Glu  Ala Gly Gly 
    1145                 1150                 1155             


Ala Thr  Ser Ala Gln Ile Glu  Met Asn Lys Lys Arg  Glu Ala Glu 
    1160                 1165                 1170             


Phe Gln  Lys Met Arg Arg Asp  Leu Glu Glu Ala Thr  Leu Gln His 
    1175                 1180                 1185             


Glu Ala  Thr Ala Ala Ala Leu  Arg Lys Lys His Ala  Asp Ser Val 
    1190                 1195                 1200             


Ala Glu  Leu Gly Glu Gln Ile  Asp Asn Leu Gln Arg  Val Lys Gln 
    1205                 1210                 1215             


Lys Leu  Glu Lys Glu Lys Ser  Glu Met Lys Met Glu  Ile Asp Asp 
    1220                 1225                 1230             


Leu Ala  Ser Asn Met Glu Thr  Val Ser Lys Ala Lys  Gly Asn Leu 
    1235                 1240                 1245             


Glu Lys  Met Cys Arg Thr Leu  Glu Asp Gln Leu Ser  Glu Leu Lys 
    1250                 1255                 1260             


Ser Lys  Glu Glu Glu Gln Gln  Arg Leu Val Asn Asp  Leu Thr Gly 
    1265                 1270                 1275             


Gln Arg  Ala Arg Leu Gln Thr  Glu Ala Gly Glu Tyr  Ser Arg Gln 
    1280                 1285                 1290             


Leu Asp  Glu Lys Asp Ser Leu  Val Ser Gln Leu Ser  Arg Gly Lys 
    1295                 1300                 1305             


Gln Ala  Phe Thr Gln Gln Ile  Glu Glu Leu Lys Arg  Gln Leu Glu 
    1310                 1315                 1320             


Glu Glu  Ile Lys Ala Lys Ser  Ala Leu Ala His Ala  Leu Gln Ser 
    1325                 1330                 1335             


Ala Arg  His Asp Cys Asp Leu  Leu Arg Glu Gln Tyr  Glu Glu Glu 
    1340                 1345                 1350             


Gln Glu  Ala Lys Ala Glu Leu  Gln Arg Ala Met Ser  Lys Ala Asn 
    1355                 1360                 1365             


Ser Glu  Val Ala Gln Trp Arg  Thr Lys Tyr Glu Thr  Asp Ala Ile 
    1370                 1375                 1380             


Gln Arg  Thr Glu Glu Leu Glu  Glu Ala Lys Lys Lys  Leu Ala Gln 
    1385                 1390                 1395             


Arg Leu  Gln Asp Ala Glu Glu  His Val Glu Ala Val  Asn Ala Lys 
    1400                 1405                 1410             


Cys Ala  Ser Leu Glu Lys Thr  Lys Gln Arg Leu Gln  Asn Glu Val 
    1415                 1420                 1425             


Glu Asp  Leu Met Ile Asp Val  Glu Arg Thr Asn Ala  Ala Cys Ala 
    1430                 1435                 1440             


Ala Leu  Asp Lys Lys Gln Arg  Asn Phe Asp Lys Ile  Leu Ser Glu 
    1445                 1450                 1455             


Trp Lys  His Lys Tyr Glu Glu  Thr His Ala Glu Leu  Glu Ala Ser 
    1460                 1465                 1470             


Gln Lys  Glu Ser Arg Ser Leu  Ser Thr Glu Leu Phe  Lys Val Lys 
    1475                 1480                 1485             


Asn Ala  Tyr Glu Glu Ser Leu  Asp Gln Leu Glu Thr  Leu Lys Arg 
    1490                 1495                 1500             


Glu Asn  Lys Asn Leu Gln Gln  Glu Ile Ser Asp Leu  Thr Glu Gln 
    1505                 1510                 1515             


Ile Ala  Glu Gly Gly Lys Arg  Ile His Glu Leu Glu  Lys Val Lys 
    1520                 1525                 1530             


Lys Gln  Ile Glu Gln Glu Lys  Ser Glu Ile Gln Ala  Ala Leu Glu 
    1535                 1540                 1545             


Glu Ala  Glu Ala Ser Leu Glu  His Glu Glu Gly Lys  Ile Leu Arg 
    1550                 1555                 1560             


Ile Gln  Leu Glu Leu Asn Gln  Val Lys Ser Glu Ile  Asp Arg Lys 
    1565                 1570                 1575             


Ile Ala  Glu Lys Asp Glu Glu  Ile Asp Gln Leu Lys  Arg Asn His 
    1580                 1585                 1590             


Val Arg  Val Val Glu Thr Met  Gln Thr Met Leu Asp  Ala Glu Ile 
    1595                 1600                 1605             


Arg Ser  Arg Asn Asp Ala Ile  Arg Ile Lys Lys Lys  Met Glu Gly 
    1610                 1615                 1620             


Asp Leu  Asn Glu Met Glu Ile  Gln Leu Asn His Ala  Asn Arg Met 
    1625                 1630                 1635             


Ala Ala  Glu Ala Leu Arg Asn  Tyr Arg Asn Thr Gln  Gly Ile Leu 
    1640                 1645                 1650             


Lys Asp  Thr Gln Leu His Leu  Asp Asp Ala Leu Arg  Gly Gln Glu 
    1655                 1660                 1665             


Asp Leu  Lys Glu Gln Leu Ala  Met Val Glu Arg Arg  Ala Asn Leu 
    1670                 1675                 1680             


Leu Gln  Ala Glu Ile Glu Glu  Leu Arg Ala Thr Leu  Glu Gln Thr 
    1685                 1690                 1695             


Glu Arg  Ser Arg Lys Ile Ala  Glu Gln Glu Leu Leu  Asp Ala Ser 
    1700                 1705                 1710             


Glu Arg  Val Gln Leu Leu His  Thr Gln Asn Thr Ser  Leu Ile Asn 
    1715                 1720                 1725             


Thr Lys  Lys Lys Leu Glu Thr  Asp Ile Ser Gln Leu  Gln Gly Glu 
    1730                 1735                 1740             


Met Glu  Asp Ile Val Gln Glu  Ala His Asn Ala Glu  Glu Lys Ala 
    1745                 1750                 1755             


Lys Lys  Ala Ile Thr Asp Ala  Ala Met Met Ala Glu  Glu Leu Lys 
    1760                 1765                 1770             


Lys Glu  Gln Asp Thr Ser Ala  His Leu Glu Arg Met  Lys Lys Asn 
    1775                 1780                 1785             


Leu Glu  Gln Thr Val Lys Asp  Leu Gln His Arg Leu  Asp Glu Ala 
    1790                 1795                 1800             


Glu Gln  Leu Ala Leu Lys Gly  Gly Lys Lys Gln Ile  Gln Lys Leu 
    1805                 1810                 1815             


Glu Ala  Arg Val Arg Asp Leu  Glu Gly Glu Val Glu  Ser Glu Gln 
    1820                 1825                 1830             


Lys Arg  Asn Val Glu Ala Val  Lys Gly Leu Arg Lys  His Glu Arg 
    1835                 1840                 1845             


Arg Val  Lys Glu Leu Thr Tyr  Gln Thr Glu Glu Asp  Arg Lys Asn 
    1850                 1855                 1860             


Ile Leu  Arg Leu Gln Asp Leu  Val Asp Lys Leu Gln  Ser Lys Val 
    1865                 1870                 1875             


Lys Ala  Tyr Lys Arg Gln Ala  Glu Glu Ala Glu Glu  Gln Ser Asn 
    1880                 1885                 1890             


Val Asn  Leu Ser Lys Phe Arg  Lys Ile Gln His Glu  Leu Glu Glu 
    1895                 1900                 1905             


Ala Glu  Glu Arg Ala Asp Ile  Ala Glu Ser Gln Val  Asn Lys Leu 
    1910                 1915                 1920             


Arg Val  Lys Ser Arg Glu Val  His Thr Lys Ile Ile  Ser Glu Glu 
    1925                 1930                 1935             


<210> 2
<211> 5984
<212> DNA
<213> Equus caballus

<400> 2
ttaggaaaga ggaggaggct atgtgttttc catatttgat cgtataaaag tacccttgga       60

atgagtatga cctgtctttc ctcataaagc ttcaagttct gacccacttc aaggccgcat      120

ctctaaggca gggtctttga ctgggcctcc atcaataacc cgcagccatg agttcagacc      180

aggaaatggc tatatttggg gaggctgctc cttacctccg aaagtctgaa aaggagcgaa      240

ttgaagccca gaataagcct ttcgatgcca agacatcagt ttttgtggct gaccctaagg      300

agtcctttgt gaaagcaaca gtgcagagca gggaaggagg gaaggtgaca gccaagactg      360

aagctggagc tacagtaact gtgaaagaag accaatgctt ccccatgaac cctcccaaat      420

atgacaagat cgaggacatg gccatgatga ctcacctgca tgagcctgct gtgctgtaca      480

acctcaaaga gcgctacgca gcctggatga tctacaccta ctcaggtctt ttctgtgtca      540

ccgtcaaccc ctacaagtgg ttgccagtgt acaacgccga ggtggtgacg gcctaccgag      600

gcaaaaagcg ccaggaggcc ccgccccaca tcttctccat ctctgacaac gcctatcagt      660

tcatgctgac tgatcgggag aatcagtcta tcttaatcac tggagaatct ggtgccggga      720

agactgtgaa taccaagcgt gtcatccagt actttgcaac aattgcagtt actggggaga      780

agaagaagga ggaacctact tccggcaaaa tgcaggggac tctggaagat cagatcatca      840

gtgccaaccc cctactggag gcctttggca acgccaagac cgtgaggaat gacaactcct      900

ctcgctttgg taaattcatc aggatccact tcggtaccac agggaaactg gcttctgctg      960

atattgaaac atatcttctg gagaagtcta gagttacttt ccagctaaag gcggaaagaa     1020

gctaccacat tttttatcag atcatgtcta acaagaagcc agatctaatt gaaatgctcc     1080

tgatcaccac caacccgtat gactatgcct ttgtcagtca aggggrgatc acagtcccca     1140

gcattgatga ccaagaagag ttgatggcca cagatagtgc cattgagatc ttgggcttca     1200

cttctgatga aagagtgtcc atctataagc tcacaggggc agtaatgcat tacgggaacc     1260

tgaaattcaa gcagaagcag cgtgaggagc aagctgagcc agatggcact gaagttgctg     1320

acaaggctgc ctatcttcag ggtctgaact ctgctgacct gctcaaagct ctctgctacc     1380

ccagggtcaa ggtcggcaat gagttcgtca ccaaaggcca gactgtagaa caggtgtaca     1440

atgcggtggg tgctctggcc aaagccgtct acgataagat gttcctctgg atggtcgccc     1500

gcatcaacca gcagctggac accaagcagc ccaggcagta cttcatcggg gtcttggaca     1560

tcgctggctt tgagatcttt gatttcaaca gcctggagca gctgtgcatc aacttcacca     1620

acgagaaact gcaacagttt ttcaaccacc acatgttcgt gctggagcag gaggagtaca     1680

agaaggaagg catcgagtgg gagttcatcg acttcggcat ggacctggct gcctgcattg     1740

agctcatcga gaagccgatg ggcatcttct ccatcctgga agaggagtgc atgttcccca     1800

aggccacaga cacctccttc aagaacaagc tgtatgaaca gcatcttgga aagtccaaca     1860

atttccagaa gcctaaacct gtcaaaggca agcctgaggc ccacttctcc ctgattcact     1920

acgccggcac tgtggactac aacattactg gctggcttga caagaacaag gaccccctga     1980

atgagaccgt ggtcgggctg taccagaagt cttcagtgaa gactctggct ttgctcttct     2040

ctgggccagc aagtgctgat gcggaggctg gtggaaagaa aggaggcaag aagaagggtt     2100

cttctttcca gaccgtgtct gcgctcttca gggagaattt gaataagctg atgaccaacc     2160

tgaggagcac tcaccctcac tttgtacggt gcatcatccc caatgaaacc aaaactcctg     2220

gtgccatgga gcatgaactt gtcctgcacc agctgaggtg caatggtgtg ctggaaggca     2280

tccgcatctg cagaaaggga ttcccaagca ggatccttta tgcagacttc aaacagagat     2340

acaaggtatt aaatgcaagt gctatccctg aaggacaatt catcgatagc aagaaggcgt     2400

ctgagaagct ccttgggtcc attgacattg accacaccca gtacaaattt ggtcacacca     2460

aggtcttctt caaagctggt ctcctggggc tcctagagga gatgcgagat gacaagctgg     2520

cccagataat tacccgaacc caggccaggt gcagagggtt cttggcaaga gtggagtacc     2580

agaggatggt ggagagaaga gagtccatct tctgcatcca gtacaatgtc cgtgccttca     2640

tgaacgtgaa gcactggccc tggatgaagc tgtatttcaa gatcaagccc ctcctcaaga     2700

gtgcagagac agagaaagag atggccaaca tgaaggaaga attcgagaag accaaagaaa     2760

gccttgcaaa ggctgaggcc aaaagaaaag agctggaaga aaaaatggta gctctgatgc     2820

aagagaaaaa cgacctgcaa cttcaggttc aagctgaagc agacagtttg gctgatgcag     2880

aggaaagatg tgaccagctg attaaaacca aaatccagct ggaggccaaa atcaaggagg     2940

cgactgagag agctgaggat gaggaagaga tcaacgctga gctgacggcc aagaagagga     3000

aactggagga cgaatgctca gagctcaaga aggacattga tgaccttgag ctgacactgg     3060

ccaaggttga aaaggagaaa catgccacag aaaataaggt gaaaaacctc acagaggaga     3120

tggcaggcct ggacgaaacc atcgctaagc tgaccaagga gaagaaggcc ctccaagagg     3180

cccaccagca gaccctggat gacctgcagg cagaagagga caaggtcaac actctgacca     3240

aagctaaaac caagctagag cagcaagtgg atgatcttga aggatctcta gagcaagaaa     3300

agaaacttcg aatggatcta gaaagagcaa agaggaaact ggagggtgac ctaaaattgg     3360

cccaagaatc cacaatggac atagaaaatg acaaacagca acttgatgaa aaactgaaaa     3420

agaaagagtt tgaaatgagc aatctgcaaa gcaagattga agatgagcag gcccttgcga     3480

tgcagctgca gaagaagatc aaggagttac aggcccgcat cgaggagctg gaggaggaaa     3540

tcgaggcaga gcgcgcctcc cgggccaaag cagagaagca gcgctccgac ctctcccggg     3600

aactggagga gatcagcgag aggctcgaag aagccggtgg ggcgacttca gcccagattg     3660

agatgaacaa gaagcgggag gctgagttcc agaaaatgcg cagggacctg gaggaggcca     3720

ccctgcagca tgaagccacg gcggccgctc tgcggaagaa gcacgcggac agtgtggcag     3780

agctcgggga gcagatagac aacctgcaga gagtcaagca gaaactggag aaggagaaga     3840

gcgaaatgaa gatggagatt gacgacctgg cgagcaacat ggagactgtc tccaaagcca     3900

agggcaacct tgaaaagatg tgccgcaccc tggaagatca actgagtgaa cttaagagca     3960

aagaggaaga gcagcagagg ctggtcaatg acctgacggg ccagagagcg cgcctgcaga     4020

cagaagcagg tgaatattca cgccagctag atgaaaagga ctcattagtt tctcagctct     4080

caaggggcaa acaagcattc acacaacaga ttgaggaact gaaaaggcag cttgaagagg     4140

agataaaggc caagagtgcc ctggcccatg ccctgcagtc agcccgccat gattgtgacc     4200

tgctgcggga acagtacgag gaggagcagg aagccaaggc cgagctgcag agggcaatgt     4260

ccaaggccaa cagtgaggtt gcccagtgga ggaccaagta cgagacggac gccatccagc     4320

gcacggagga gctggaggag gccaagaaga agctggctca gcggctgcag gatgctgagg     4380

aacacgtaga agctgtgaat gccaaatgtg cttcccttga gaagaccaag cagcggctcc     4440

agaatgaagt ggaggacctc atgattgatg ttgagagaac caatgctgcc tgtgcagccc     4500

tggacaaaaa gcaaaggaac ttcgataaga tcctgtcaga atggaagcac aagtatgaag     4560

aaactcatgc tgaacttgaa gcttcccaaa aggagtccag gtcactcagc acagagctgt     4620

tcaaggttaa gaatgcttat gaggaatcct tagaccaact tgaaaccttg aagcgggaaa     4680

ataagaattt gcaacaggag atttctgatc tcactgagca gattgcagaa ggagggaagc     4740

gtatccatga actggaaaaa gtaaagaagc aaattgagca agaaaagtct gaaattcagg     4800

ctgctttaga agaagcagag gcatctcttg aacacgaaga gggaaagatc ctgcgcatcc     4860

aactggagtt gaaccaagtc aagtctgaaa ttgataggaa aattgctgaa aaggatgagg     4920

aaattgacca gctgaagaga aaccatgtca gagttgtgga gacgatgcag accatgctgg     4980

atgctgagat caggagccgg aatgatgcca tcaggatcaa gaagaagatg gagggagacc     5040

tcaatgaaat ggaaatccag ctgaaccacg ccaaccgcat ggctgcagag gccctgagga     5100

actacaggaa cactcaaggc atcctcaagg acacccagct gcacctggat gacgctctcc     5160

ggggccagga ggacctgaag gagcagctgg ccatggtgga gcgcagagcc aacctgctgc     5220

aggccgagat cgaggagctg cgggccactc tggagcagac cgagaggagc aggaaaatcg     5280

cagaacagga gctcctggat gccagtgagc gcgtccagct cctgcacacc cagaacacca     5340

gcctgatcaa caccaagaag aagctggaga cagacatttc ccagctgcag ggagagatgg     5400

aagatatcgt ccaggaagct cacaatgcag aagagaaggc caagaaggcc atcactgatg     5460

cggccatgat ggctgaggag ctgaagaagg agcaggacac cagcgcccac ctggagcgga     5520

tgaagaagaa tctggagcag acggtgaagg acctgcagca ccgtctggat gaggccgagc     5580

agctggccct gaagggtggg aagaagcaga tccagaaact ggaggccagg gtacgtgacc     5640

ttgaaggaga agttgaaagt gaacagaagc gcaatgttga ggctgtcaag ggtctgcgca     5700

aacatgagag aagagtaaag gaactcactt accagactga ggaagaccgc aagaatatac     5760

tcaggctcca ggatctggtg gataaactgc aatcaaaggt gaaagcttac aagagacaag     5820

ctgaggaagc ggaggaacag tccaatgtca atctctccaa attccgcaag atccagcacg     5880

agctggagga ggccgaggaa cgggctgaca tcgccgagtc ccaggtcaac aagctgcggg     5940

tgaagagccg ggaggttcac acaaaaatca ttagtgaaga gtaa                      5984


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
cccaagatct caatggcact                                                   20


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
accttgtggg aacattcagc                                                   20


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
ggatcatctg agggggaaat                                                   20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
tggaaccttg tgggaacatt                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
atgtggaacc ttgtgggaac                                                   20


<210> 8
<211> 301
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
tgaaaccctt ggccgccgaa gtggagtgcg tgaactgaac cactcagccg tgggcccggc       60

ccactaaagg agttttttaa aaagctgcat gtgtaactta catctgtggc catcaactct      120

tcttggtcat caatgctggg gactgtgatc yccccttgac tgacaaaggc atagtcatac      180

gggttggtgg tgatcaggag catttctggg tacagagaat tcagggtatg tgttttacat      240

tagaagatgt taataaaaca gttaacttct agcttataaa tttaaactct ttcttaccaa      300

t                                                                      301


<210> 9
<211> 65
<212> PRT
<213> Equus caballus

<400> 9
Ile Phe Tyr Gln Ile Met Ser Asn Lys Lys Pro Asp Leu Ile Glu Met 
1               5                   10                  15      


Leu Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly 
            20                  25                  30          


Glu Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr 
        35                  40                  45              


Asp Ser Ala Ile Glu Ile Leu Gly Phe Thr Ser Asp Glu Arg Val Ser 
    50                  55                  60                  


Ile 
65  


<210> 10
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Ile Phe Tyr Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met 
1               5                   10                  15      


Leu Leu Ile Thr Asn Asn Pro Tyr Asp Tyr Ala Phe Ile Ser Gln Gly 
            20                  25                  30          


Glu Thr Thr Val Ala Ser Ile Asp Asp Ala Glu Glu Leu Met Ala Thr 
        35                  40                  45              


Asp Asn Ala Phe Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Asn Ser 
    50                  55                  60                  


Met 
65  


<210> 11
<211> 99
<212> PRT
<213> Equus caballus

<400> 11
Gly Asn Ala Lys Thr Val Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys 
1               5                   10                  15      


Phe Ile Arg Ile His Phe Gly Thr Thr Gly Lys Leu Ala Ser Ala Asp 
            20                  25                  30          


Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Val Thr Phe Gln Leu Lys 
        35                  40                  45              


Ala Glu Arg Ser Tyr His Ile Phe Tyr Gln Ile Met Ser Asn Lys Lys 
    50                  55                  60                  


Pro Asp Leu Ile Glu Met Leu Leu Ile Thr Thr Asn Pro Tyr Asp Tyr 
65                  70                  75                  80  


Ala Phe Val Ser Gln Gly Glu Ile Thr Val Pro Ser Ile Asp Asp Gln 
                85                  90                  95      


Glu Glu Leu 
            


<210> 12
<211> 1200
<212> PRT
<213> Equus caballus

<400> 12
Met Ser Ser Asp Gln Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Tyr 
1               5                   10                  15      


Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe 
            20                  25                  30          


Asp Ala Lys Thr Ser Val Phe Val Ala Asp Pro Lys Glu Ser Phe Val 
        35                  40                  45              


Lys Ala Thr Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gly Ala Thr Val Thr Val Lys Glu Asp Gln Cys Phe Pro Met 
65                  70                  75                  80  


Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His 
                85                  90                  95      


Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala 
            100                 105                 110         


Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro 
        115                 120                 125             


Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Thr Ala Tyr Arg 
    130                 135                 140                 


Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp 
145                 150                 155                 160 


Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu 
                165                 170                 175     


Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val 
            180                 185                 190         


Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu 
        195                 200                 205             


Glu Pro Thr Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Met Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Glu Ile Leu Gly Phe Thr Ser Asp Glu Arg Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Leu Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Gly Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Phe Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Glu Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Asp Lys Met Phe Leu Trp Met Val Ala Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Val Lys Gly Lys Pro 
                565                 570                 575     


Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn 
            580                 585                 590         


Ile Thr Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ser Val Lys Thr Leu Ala Leu Leu Phe 
    610                 615                 620                 


Ser Gly Pro Ala Ser Ala Asp Ala Glu Ala Gly Gly Lys Lys Gly Gly 
625                 630                 635                 640 


Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu 
                645                 650                 655     


Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe 
            660                 665                 670         


Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu 
        675                 680                 685             


His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly 
    690                 695                 700                 


Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala Asp 
705                 710                 715                 720 


Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu Gly 
                725                 730                 735     


Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser Ile 
            740                 745                 750         


Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe 
        755                 760                 765             


Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Asp Lys Leu 
    770                 775                 780                 


Ala Gln Ile Ile Thr Arg Thr Gln Ala Arg Cys Arg Gly Phe Leu Ala 
785                 790                 795                 800 


Arg Val Glu Tyr Gln Arg Met Val Glu Arg Arg Glu Ser Ile Phe Cys 
                805                 810                 815     


Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro Trp 
            820                 825                 830         


Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr 
        835                 840                 845             


Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys Glu 
    850                 855                 860                 


Ser Leu Ala Lys Ala Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Met 
865                 870                 875                 880 


Val Ala Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala 
                885                 890                 895     


Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile 
            900                 905                 910         


Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Ala Thr Glu Arg 
        915                 920                 925             


Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg 
    930                 935                 940                 


Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu 
945                 950                 955                 960 


Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn 
                965                 970                 975     


Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr Ile 
            980                 985                 990         


Ala Lys Leu Thr Lys Glu Lys Lys  Ala Leu Gln Glu Ala  His Gln Gln 
        995                 1000                 1005             


Thr Leu  Asp Asp Leu Gln Ala  Glu Glu Asp Lys Val  Asn Thr Leu 
    1010                 1015                 1020             


Thr Lys  Ala Lys Thr Lys Leu  Glu Gln Gln Val Asp  Asp Leu Glu 
    1025                 1030                 1035             


Gly Ser  Leu Glu Gln Glu Lys  Lys Leu Arg Met Asp  Leu Glu Arg 
    1040                 1045                 1050             


Ala Lys  Arg Lys Leu Glu Gly  Asp Leu Lys Leu Ala  Gln Glu Ser 
    1055                 1060                 1065             


Thr Met  Asp Ile Glu Asn Asp  Lys Gln Gln Leu Asp  Glu Lys Leu 
    1070                 1075                 1080             


Lys Lys  Lys Glu Phe Glu Met  Ser Asn Leu Gln Ser  Lys Ile Glu 
    1085                 1090                 1095             


Asp Glu  Gln Ala Leu Ala Met  Gln Leu Gln Lys Lys  Ile Lys Glu 
    1100                 1105                 1110             


Leu Gln  Ala Arg Ile Glu Glu  Leu Glu Glu Glu Ile  Glu Ala Glu 
    1115                 1120                 1125             


Arg Ala  Ser Arg Ala Lys Ala  Glu Lys Gln Arg Ser  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Leu Glu Glu Ile Ser  Glu Arg Leu Glu Glu  Ala Gly Gly 
    1145                 1150                 1155             


Ala Thr  Ser Ala Gln Ile Glu  Met Asn Lys Lys Arg  Glu Ala Glu 
    1160                 1165                 1170             


Phe Gln  Lys Met Arg Arg Asp  Leu Glu Glu Ala Thr  Leu Gln His 
    1175                 1180                 1185             


Glu Ala  Thr Ala Ala Ala Leu  Arg Lys Lys His Ala  
    1190                 1195                 1200 


<210> 13
<211> 195
<212> PRT
<213> Streptococcus equi

<400> 13
Met Phe Leu Arg Asn Asn Lys Gln Lys Phe Ser Ile Arg Lys Leu Ser 
1               5                   10                  15      


Ala Gly Ala Ala Ser Val Leu Val Ala Thr Ser Val Leu Gly Gly Thr 
            20                  25                  30          


Thr Val Lys Ala Asn Ser Glu Val Ser Arg Thr Ala Thr Pro Arg Leu 
        35                  40                  45              


Ser Arg Asp Leu Lys Asn Arg Leu Ser Asp Ile Ala Ile Ser Arg Asp 
    50                  55                  60                  


Ala Ser Ser Ala Gln Lys Val Arg Asn Leu Leu Lys Gly Ala Ser Val 
65                  70                  75                  80  


Gly Asp Leu Gln Ala Leu Leu Arg Gly Leu Asp Ser Ala Arg Ala Ala 
                85                  90                  95      


Tyr Gly Arg Asp Asp Tyr Tyr Asn Leu Leu Met His Leu Ser Ser Met 
            100                 105                 110         


Leu Asn Asp Lys Pro Asp Gly Asp Arg Arg Gln Leu Ser Leu Ala Ser 
        115                 120                 125             


Leu Leu Val Asp Glu Ile Glu Lys Arg Ile Ala Asp Gly Asp Arg Tyr 
    130                 135                 140                 


Ala Lys Leu Leu Glu Ala Lys Leu Ala Ala Ile Lys Ser Gln Gln Glu 
145                 150                 155                 160 


Met Leu Arg Glu Arg Asp Ser Gln Leu Arg Asn Leu Glu Lys Glu Lys 
                165                 170                 175     


Glu Gln Glu Leu Gln Lys Ala Lys Asp Glu Arg Gln Ala Leu Thr Glu 
            180                 185                 190         


Ser Phe Asn 
        195 


