                         SEQUENCE LISTING

<110>  IGF Oncology, LLC
       McTavish, Hugh
       Dudek, Arkadiusz Z
 
<120>  AN INSULIN-LIKE GROWTH FACTOR-CHEMOTHERAPEPUTIC CONJUGATE FOR 
       TREATING MYELODYSPLASTIC SYNDROME

<130>  102.009WO2

<150>  US 62/509,150
<151>  2017-05-21

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  1

Met Val Lys Gly Lys His His His His His His Asn Gly Lys Gly Lys 
1               5                   10                  15      


Ser Lys 
        


<210>  2
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  2

Met Val Lys Gly Lys His His His His His His Asn Gly Lys Gly Lys 
1               5                   10                  15      


Ser Lys Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly 
        35                  40                  45              


Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu 
    50                  55                  60                  


Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala 
65                  70                  75                  80  


Pro Leu Lys Pro Ala Lys Ser Ala 
                85              


<210>  3
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  4
<211>  71
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr 
            20                  25                  30          


Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys 
        35                  40                  45              


Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro 
    50                  55                  60                  


Leu Lys Pro Ala Lys Ser Ala 
65                  70      


<210>  5
<211>  83
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  5

Met Phe Pro Ala Met Pro Leu Ser Ser Leu Phe Val Asn Gly Pro Arg 
1               5                   10                  15      


Thr Leu Cys Gly Ala Leu Val Asp Ala Leu Gln Phe Val Cys Gly Asp 
            20                  25                  30          


Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg 
        35                  40                  45              


Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys 
    50                  55                  60                  


Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys 
65                  70                  75                  80  


Ser Glu Ala 
            


<210>  6
<211>  70
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  6

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  7
<211>  67
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  7

Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 
1               5                   10                  15      


Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
            20                  25                  30          


Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 
        35                  40                  45              


Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 
    50                  55                  60                  


Lys Ser Ala 
65          


<210>  8
<211>  87
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  8

Met Thr Ser Gly His His His His His His Ser Ala Gly Val Asn Gly 
1               5                   10                  15      


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
            20                  25                  30          


Leu Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr 
        35                  40                  45              


Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys 
    50                  55                  60                  


Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro 
65                  70                  75                  80  


Leu Lys Pro Ala Lys Ser Ala 
                85          


<210>  9
<211>  190
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  9

Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp 
1               5                   10                  15      


Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys 
            20                  25                  30          


Gly His Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys 
        35                  40                  45              


Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Ser Gln Asp 
    50                  55                  60                  


Val Ala Ser Glu Ser Glu Val Lys Ser Met Pro Thr Phe Gln Phe Phe 
65                  70                  75                  80  


Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys 
                85                  90                  95      


Leu Glu Ala Thr Ile Asn Glu Leu Val Gly Ser Lys Ser Gly His His 
            100                 105                 110         


His His His His Ser Ala Lys Gly Gly Pro Arg Thr Leu Cys Gly Ala 
        115                 120                 125             


Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr 
    130                 135                 140                 


Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln 
145                 150                 155                 160 


Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg 
                165                 170                 175     


Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys Ser Ala 
            180                 185                 190 


<210>  10
<211>  191
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  10

Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp 
1               5                   10                  15      


Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys 
            20                  25                  30          


Gly His Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys 
        35                  40                  45              


Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Ser Gln Asp 
    50                  55                  60                  


Val Ala Ser Glu Ser Glu Val Lys Ser Met Pro Thr Phe Gln Phe Phe 
65                  70                  75                  80  


Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys 
                85                  90                  95      


Leu Glu Ala Thr Ile Asn Glu Leu Val Gly Ser Lys Ser Gly His His 
            100                 105                 110         


His His His His Ser Ala Lys Gly Phe Val Asn Gln His Leu Cys Gly 
        115                 120                 125             


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Asp Arg Gly Phe 
    130                 135                 140                 


Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro 
145                 150                 155                 160 


Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg 
                165                 170                 175     


Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys Ser Ala 
            180                 185                 190     


<210>  11
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  11

Met Val Lys Gly Lys His His His His His His Asn Gly Lys Gly Lys 
1               5                   10                  15      


Ser Lys Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
            20                  25                  30          


Leu Tyr Leu Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
        35                  40                  45              


Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp 
    50                  55                  60                  


Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys 
65                  70                  75                  80  


Ala Pro Leu Lys Pro Ala Lys Ser Ala 
                85                  


