                         SEQUENCE LISTING

<110>  Technion Research & Development Foundation Limited
       YABLONSKI, Deborah
 
<120>  AGENTS WHICH INHIBIT GADS DIMERIZATION AND METHODS OF USE THEREOF

<130>  73910

<150>  US 62/509,795
<151>  2017-05-23

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Thr 
            180                 185                 190         


Leu Pro Leu Gln Gln His Gln His Gln Pro Gln Pro Pro Gln Tyr Ala 
        195                 200                 205             


Pro Ala Pro Gln Gln Leu Gln Gln Pro Pro Gln Gln Arg Tyr Leu Gln 
    210                 215                 220                 


His His His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp Ile Asn 
225                 230                 235                 240 


Asp Gly His Cys Gly Thr Gly Leu Gly Ser Glu Met Asn Ala Ala Leu 
                245                 250                 255     


Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly Arg 
            260                 265                 270         


Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp Asp 
        275                 280                 285             


Glu Leu Gly Phe His Ser Gly Glu Val Val Glu Val Leu Asp Ser Ser 
    290                 295                 300                 


Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu Phe 
305                 310                 315                 320 


Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
                325                 330 


<210>  2
<211>  322
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Ala Thr Ala Lys Phe Asp Phe Met Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe Arg Thr Gly Asp Ile Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Leu Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Glu Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Asp Ile Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Thr Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Val Phe 
    130                 135                 140                 


Leu Arg Asp Gly Thr Gln Asp Gln Gly His Arg Gly Asn Ser Leu Asp 
145                 150                 155                 160 


Arg Arg Ser Gln Gly Gly Pro His Pro Ser Gly Thr Val Gly Glu Glu 
                165                 170                 175     


Ile Arg Pro Ser Val Asn Arg Lys Leu Ser Asp His Leu Pro Leu Gly 
            180                 185                 190         


Pro Gln Gln Phe His Pro His Gln Gln Pro Ser Pro Gln Phe Thr Pro 
        195                 200                 205             


Gly Pro Gln Pro Pro Gln Gln Gln Arg Tyr Leu Gln His Phe His Gln 
    210                 215                 220                 


Asp Arg Arg Gly Gly Ser Leu Asp Ile Asn Asp Gly His Cys Gly Leu 
225                 230                 235                 240 


Gly Ser Glu Val Asn Ala Thr Leu Met His Arg Arg His Thr Asp Pro 
                245                 250                 255     


Val Gln Leu Gln Ala Ala Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr 
            260                 265                 270         


Asp Phe Glu Ala Leu Glu Glu Asp Glu Leu Gly Phe Arg Ser Gly Glu 
        275                 280                 285             


Val Val Glu Val Leu Asp Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg 
    290                 295                 300                 


Leu His Asn Lys Leu Gly Leu Phe Pro Ala Asn Tyr Val Ala Pro Met 
305                 310                 315                 320 


Met Arg 
        


<210>  3
<211>  296
<212>  PRT
<213>  Corvus brachyrhynchos

<400>  3

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe Gln Ala Gly Asp Met Leu Lys Ile Leu Ser Ser Gln Glu 
            20                  25                  30          


Glu Trp Tyr Lys Ala Glu Leu Arg Ser His Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Phe His Val Pro Pro Trp Phe Asp Glu Lys Ile Ser 
    50                  55                  60                  


Arg His Glu Ala Glu Asn Leu Leu Met Ser Lys Gly Val Gly Cys Phe 
65                  70                  75                  80  


Val Val Arg Ala Ser Gln Asn Ser His Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Ser Lys 
            100                 105                 110         


Gly Ser Tyr Tyr Leu Trp Thr Glu Lys Phe His Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Lys Thr Ala Ser Ile Ser Arg Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Lys Asp Asn Ser Gln Glu Glu Lys Glu Arg Arg Gly Gly Ser Leu 
145                 150                 155                 160 


Glu Arg Ile Gly Arg Glu Gly Phe His Leu Gly Gly Ala Ala Gly Glu 
                165                 170                 175     


Asp Arg Ser Ala Ile Ser Lys Arg Tyr Val Glu His Pro Ile Pro Ile 
            180                 185                 190         


Leu Gln Gln Gln Gln Glu Arg Tyr Gly Gly Ser Leu Asp Arg Lys Asp 
        195                 200                 205             


Met Leu Gln Gly Leu Arg Asp His Gly Gln Gly Asn Ala Gly Ala Met 
    210                 215                 220                 


Gln Arg Arg His Thr Asp Pro Leu His Gln Gln Thr Pro Arg Thr Leu 
225                 230                 235                 240 


Trp Val Arg Ala Leu Tyr Asp Phe Asp Ala Met Glu His Asp Glu Leu 
                245                 250                 255     


Gly Phe Arg Ser Gly Asp Ile Leu Glu Val Leu Asp Asn Ser Asn Pro 
            260                 265                 270         


Ser Trp Trp Lys Gly Arg Leu Arg Gly Glu Leu Gly Leu Phe Pro Ala 
        275                 280                 285             


Asn Tyr Val Thr Pro Val Leu Leu 
    290                 295     


<210>  4
<211>  296
<212>  PRT
<213>  Gallus gallus

<400>  4

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe Gln Ala Gly Asp Ile Leu Lys Ile Leu Ser Ser Gln Glu 
            20                  25                  30          


Glu Trp Tyr Lys Ala Glu Leu Arg Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Phe His Val Pro Pro Trp Phe Asp Glu Lys Ile Ser 
    50                  55                  60                  


Arg His Glu Ala Glu Ser Ile Leu Met Asn Lys Gly Val Gly Ser Phe 
65                  70                  75                  80  


Ile Val Arg Ala Ser Gln Asn Ser His Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Ser Lys 
            100                 105                 110         


Gly Asn Tyr Tyr Leu Trp Thr Glu Lys Phe Tyr Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Ser Thr Ile Ser Arg Gln Lys Gln Ile Leu 
    130                 135                 140                 


Leu Arg Asp Asp Ser Arg Glu Glu Lys Glu Arg Arg Gly Gly Ser Leu 
145                 150                 155                 160 


Glu Arg Met Ser Arg Asp Gly Leu His Val Gly Gly Ala Ala Ala Glu 
                165                 170                 175     


Ala His Ser Ser Met Ser Lys Arg Tyr Val Asp His Pro Val Pro Val 
            180                 185                 190         


Leu His Gln Gln Gln Asp Arg Tyr Gly Gly Ser Leu Asp Arg Lys Asp 
        195                 200                 205             


Ala Leu His Gly Leu Arg Tyr His Ser Gln Gly Ser Ala Ala Ala Met 
    210                 215                 220                 


Gln Arg Arg His Thr Asp Pro Leu His Gln Gln Thr Pro Arg Ile Leu 
225                 230                 235                 240 


Trp Val Arg Ala Leu Tyr Asp Phe Asp Ala Val Glu His Asp Glu Leu 
                245                 250                 255     


Gly Phe Arg Ser Gly Asp Ile Val Glu Val Leu Asp Asn Ser Asn Pro 
            260                 265                 270         


Ser Trp Trp Lys Gly Arg Leu Arg Gly Glu Leu Gly Leu Phe Pro Ala 
        275                 280                 285             


Asn Tyr Val Thr Pro Val Leu Leu 
    290                 295     


<210>  5
<211>  326
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Glu Ala Ile Ala Lys Phe Asp Phe Met Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Ile Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Leu Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Lys Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Ile Gly Phe Phe 
65                  70                  75                  80  


Val Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Thr Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Gly Thr Gln Asp Gln Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Thr Gln Gly Gly Pro Pro Arg Glu Val Pro Ser Gly Thr 
                165                 170                 175     


Ala Gly Glu Glu Ile Arg Pro Leu Met Asn Arg Lys Leu Ser Asp His 
            180                 185                 190         


Leu Pro Leu Gly Thr Gln Gln Phe His Pro His Gln Gln Leu Pro Pro 
        195                 200                 205             


Gln Phe Pro Pro Gly Pro Gln Pro Pro Pro Gln Gln Arg Tyr Leu Gln 
    210                 215                 220                 


His Phe His Gln Asp Arg Arg Gly Gly Ser Leu Asp Ile Asn Asp Gly 
225                 230                 235                 240 


His Leu Gly Ile Gly Ser Glu Met Asn Ala Thr Leu Met His Arg Arg 
                245                 250                 255     


His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly Arg Val Arg Trp Ala 
            260                 265                 270         


Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Glu Asp Glu Leu Gly Leu 
        275                 280                 285             


Arg Ser Gly Glu Val Val Glu Val Leu Asp Ser Ser Asn Pro Ser Trp 
    290                 295                 300                 


Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu Phe Pro Ala Asn Tyr 
305                 310                 315                 320 


Val Ala Pro Met Met Arg 
                325     


<210>  6
<211>  316
<212>  PRT
<213>  Bos taurus

<400>  6

Met Glu Ala Ile Ala Lys Phe Asp Phe Met Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Gly Phe His Ala Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Gly 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Glu Ile Glu Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Ser Leu Leu Met Gly Lys Glu Leu Gly Cys Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Lys Asn Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Glu Gln Gly Gln Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly His Pro Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Pro Ser Asp His Pro Leu Leu 
            180                 185                 190         


Pro Pro Ser Gln Tyr Pro Pro Ala Pro Leu Pro Ala Gln Gln Arg Tyr 
        195                 200                 205             


Met Pro Gln His His Phe Asn Gln Glu Arg Arg Gly Ala Ser Leu Asp 
    210                 215                 220                 


Ile Asn Asp Gly Pro Cys Gly Leu Gly Met Ser Thr Glu Met Asn Ala 
225                 230                 235                 240 


Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala 
                245                 250                 255     


Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu 
            260                 265                 270         


Asp Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp 
        275                 280                 285             


Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly 
    290                 295                 300                 


Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Ile Arg 
305                 310                 315     


<210>  7
<211>  315
<212>  PRT
<213>  Ovis aries

<400>  7

Met Glu Ala Ile Ala Lys Phe Asp Phe Met Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Ala Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Lys Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Ser Leu Leu Met Gly Lys Glu Leu Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Lys Asn Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Glu Gln Gly Gln Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly His Pro Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Met Arg Pro Ser Met Asn Arg Lys Pro Ser Asp His Pro Leu Leu 
            180                 185                 190         


Pro Ala Ser Gln Tyr Pro Pro Ala Pro Leu Gln Ser Gln Gln Arg Gln 
        195                 200                 205             


His Gln His His Phe Asn Gln Glu Arg Arg Gly Thr Ser Leu Asp Ile 
    210                 215                 220                 


Asn Asp Gly Pro Cys Gly Leu Gly Met Gly Thr Glu Met Asn Ala Ala 
225                 230                 235                 240 


Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala Gly 
                245                 250                 255     


Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp 
            260                 265                 270         


Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp Ser 
        275                 280                 285             


Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu 
    290                 295                 300                 


Phe Pro Ala Asn Tyr Val Ala Pro Met Ile Arg 
305                 310                 315 


<210>  8
<211>  318
<212>  PRT
<213>  Capra hircus

<400>  8

Met Glu Ala Ile Ala Lys Phe Asp Phe Met Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Ala Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Glu Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Ser Leu Leu Met Gly Lys Glu Leu Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Lys Asn Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Glu Gln Gly Gln Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly His Pro Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Pro Ser Asp His Pro Leu Leu 
            180                 185                 190         


Pro Ala Ser Gln Tyr Pro Pro Ala Pro Leu Gln Ser Gln Gln Arg Tyr 
        195                 200                 205             


Leu Pro Gln His Gln His His Phe Asn Gln Glu Arg Arg Gly Thr Ser 
    210                 215                 220                 


Leu Asp Ile Asn Asp Gly Pro Cys Gly Leu Gly Met Gly Thr Glu Met 
225                 230                 235                 240 


Asn Ala Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln 
                245                 250                 255     


Val Ala Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala 
            260                 265                 270         


Leu Glu Asp Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val 
        275                 280                 285             


Leu Asp Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys 
    290                 295                 300                 


Leu Gly Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Ile Arg 
305                 310                 315             


<210>  9
<211>  317
<212>  PRT
<213>  Orcinus orca

<400>  9

Met Glu Ala Ile Ala Lys Phe Asp Phe Met Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Ala Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Arg Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Lys Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Ser Leu Leu Met Gly Lys Glu Val Gly Cys Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Gly Asp Val Gln His Phe Lys Val Met Lys Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Glu Gln Gly Gln Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly Pro Pro Leu Ser Gly Thr Ala Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Pro 
            180                 185                 190         


Pro Pro Ser Gln Tyr Pro Pro Ala Pro Leu Pro Pro Gln Gln Arg Tyr 
        195                 200                 205             


Leu Gln Gln Gln Gln Pro Phe His Gln Glu Arg Arg Gly Gly Ser Leu 
    210                 215                 220                 


Asp Ile Asn Asp Gly His Cys Gly Met Gly Asn Ser Ser Glu Met Asn 
225                 230                 235                 240 


Ala Ala Leu Met Gln Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala 
                245                 250                 255     


Ala Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu 
            260                 265                 270         


Glu Asp Asp Glu Leu Gly Phe His Cys Gly Glu Val Val Glu Val Leu 
        275                 280                 285             


Asp Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu 
    290                 295                 300                 


Gly Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
305                 310                 315         


<210>  10
<211>  316
<212>  PRT
<213>  Equus caballus

<400>  10

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Ala Ser Ile Ser Arg Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly Arg Arg Gly Ser Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Leu Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Pro 
            180                 185                 190         


Ala Pro Leu Gln Tyr Pro Pro Ala Pro Pro Pro Gln Gln Gln Arg Tyr 
        195                 200                 205             


Leu Gln His Pro His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp 
    210                 215                 220                 


Ile Asn Asp Gly His Cys Gly Met Gly Val Gly Ser Glu Met Asn Ala 
225                 230                 235                 240 


Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala 
                245                 250                 255     


Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu 
            260                 265                 270         


Asp Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp 
        275                 280                 285             


Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Arg Leu Gly 
    290                 295                 300                 


Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
305                 310                 315     


<210>  11
<211>  316
<212>  PRT
<213>  Ceratotherium simum simum

<400>  11

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly Arg Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Leu Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Pro 
            180                 185                 190         


Ala Pro Leu Gln Tyr Pro Pro Gly Pro Pro Pro Gln Gln Gln Arg Tyr 
        195                 200                 205             


Leu Gln His His His Leu His Gln Glu Arg Arg Gly Gly Ser Leu Asp 
    210                 215                 220                 


Ile Asn Asp Gly His Cys Gly Leu Gly Met Gly Gly Glu Met Asn Ala 
225                 230                 235                 240 


Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala 
                245                 250                 255     


Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu 
            260                 265                 270         


Asp Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp 
        275                 280                 285             


Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly 
    290                 295                 300                 


Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
305                 310                 315     


<210>  12
<211>  315
<212>  PRT
<213>  Felis catus

<400>  12

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Thr Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Pro Gln Gly Gly Pro His Leu Ser Gly Pro Gly Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Ala Pro 
            180                 185                 190         


Pro Pro Ser Gln Tyr Pro Pro Ala Pro Pro Gln Gln Gln Arg Tyr Leu 
        195                 200                 205             


Gln His Pro His Phe His Gln Glu Arg Arg Gly Thr Ser Leu Asp Ile 
    210                 215                 220                 


Asn Asp Gly His Cys Gly Val Gly Met Ala Ser Glu Met Asn Ala Ala 
225                 230                 235                 240 


Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala Gly 
                245                 250                 255     


Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp 
            260                 265                 270         


Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp Ser 
        275                 280                 285             


Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu 
    290                 295                 300                 


Phe Pro Ala Asn Tyr Val Ala Pro Met Met Arg 
305                 310                 315 


<210>  13
<211>  316
<212>  PRT
<213>  Odobenus rosmarus divergens

<400>  13

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Glu Ile Gln Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Arg Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Pro Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Thr Arg Lys Leu Ser Asp Arg Pro Ala Pro 
            180                 185                 190         


Pro Pro Ser Gln Cys Pro Pro Ala Pro Pro Ala Gln Gln His Arg Tyr 
        195                 200                 205             


Leu Gln His Pro His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp 
    210                 215                 220                 


Ile Asn Asp Gly His Cys Gly Met Gly Val Gly Gly Asp Met Asn Pro 
225                 230                 235                 240 


Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala 
                245                 250                 255     


Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu 
            260                 265                 270         


Glu Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp 
        275                 280                 285             


Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly 
    290                 295                 300                 


Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Ile Arg 
305                 310                 315     


<210>  14
<211>  316
<212>  PRT
<213>  Ursus maritimus

<400>  14

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Pro Gln Gly Gly Pro His Leu Ser Gly Thr Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Ile Arg Lys Leu Ser Asp His Pro Ala Pro 
            180                 185                 190         


Pro Pro Ser Pro Tyr Pro Pro Ala Pro Pro Ala Gln Gln His Arg Tyr 
        195                 200                 205             


Leu Gln His Pro His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp 
    210                 215                 220                 


Ile Asn Asp Gly His Cys Gly Leu Gly Val Gly Ser Glu Val Asn Ala 
225                 230                 235                 240 


Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala 
                245                 250                 255     


Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu 
            260                 265                 270         


Asp Asp Glu Leu Gly Phe Arg Cys Gly Glu Val Val Glu Val Leu Asp 
        275                 280                 285             


Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly 
    290                 295                 300                 


Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Ile Arg 
305                 310                 315     


<210>  15
<211>  316
<212>  PRT
<213>  Canis lupus familiaris

<400>  15

Met Glu Ala Ile Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Glu Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Thr Ser Ile Ser Lys Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Pro Gln Gly Gly Leu Phe Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Pro Met Thr Arg Lys Leu Ser Asp His Pro Thr Pro 
            180                 185                 190         


Pro Pro Ser Gln Tyr Ala Pro Ala Pro Pro Ala Gln Gln His Arg Tyr 
        195                 200                 205             


Leu Gln His Pro His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp 
    210                 215                 220                 


Ile Asn Asp Gly His Cys Gly Val Gly Met Gly Ser Glu Met Asn Ala 
225                 230                 235                 240 


Ala Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Val Ala 
                245                 250                 255     


Gly Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu 
            260                 265                 270         


Asp Asp Glu Leu Gly Phe Arg Ser Gly Glu Val Val Glu Val Leu Asp 
        275                 280                 285             


Ser Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly 
    290                 295                 300                 


Leu Phe Pro Ala Asn Tyr Val Ala Pro Met Ile Arg 
305                 310                 315     


<210>  16
<211>  242
<212>  PRT
<213>  Mus musculus

<400>  16

Met Glu Ala Asp Ala Leu Ser Pro Val Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Phe Leu Val Thr Leu Leu Ala Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Val Ser Tyr Asp Ser Thr Ser Thr Glu Ser Leu Tyr Pro Arg 
        35                  40                  45              


Ser Ile Leu Ile Lys Pro Pro Gln Ile Thr Val Pro Arg Thr Pro Ala 
    50                  55                  60                  


Val Ser Tyr Pro Leu Val Thr Ser Phe Pro Pro Leu Arg Gln Pro Asp 
65                  70                  75                  80  


Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg 
                85                  90                  95      


Met Pro Ser Ser Gln Gln Asn Ser Asp Asp Ala Asn Ser Val Ala Ser 
            100                 105                 110         


Tyr Glu Asn Gln Glu Pro Ala Cys Lys Asn Val Asp Ala Asp Glu Asp 
        115                 120                 125             


Glu Asp Asp Tyr Pro Asn Gly Tyr Leu Val Val Leu Pro Asp Ser Ser 
    130                 135                 140                 


Pro Ala Ala Val Pro Val Val Ser Ser Ala Pro Val Pro Ser Asn Pro 
145                 150                 155                 160 


Asp Leu Gly Asp Ser Ala Phe Ser Val Glu Ser Cys Glu Asp Tyr Val 
                165                 170                 175     


Asn Val Pro Glu Ser Glu Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser 
            180                 185                 190         


Arg Glu Tyr Val Asn Val Ser Pro Glu Gln Gln Pro Val Thr Arg Ala 
        195                 200                 205             


Glu Leu Ala Ser Val Asn Ser Gln Glu Val Glu Asp Glu Gly Glu Glu 
    210                 215                 220                 


Glu Gly Val Asp Gly Glu Glu Ala Pro Asp Tyr Glu Asn Leu Gln Glu 
225                 230                 235                 240 


Leu Asn 
        


<210>  17
<211>  241
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Glu Ala Asp Ala Leu Ser Pro Val Glu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Phe Val Val Met Leu Leu Ala Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Ala Ser Tyr Asp Ser Ala Ser Thr Glu Ser Leu Tyr Pro Arg 
        35                  40                  45              


Ser Ile Leu Ile Lys Pro Pro Gln Ile Thr Val Pro Arg Thr Pro Ala 
    50                  55                  60                  


Thr Ser Tyr Pro Leu Val Thr Ser Phe Pro Pro Leu Arg Gln Pro Asp 
65                  70                  75                  80  


Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg 
                85                  90                  95      


Met Pro Ser Ser Arg Gln Asn Ser Asp Asp Ala Asn Ser Val Ala Ser 
            100                 105                 110         


Tyr Glu Asn Gln Glu Pro Ala Arg Lys Asn Val Asp Glu Asp Glu Asp 
        115                 120                 125             


Glu Asp Asp Tyr Pro Glu Gly Tyr Leu Val Val Leu Pro Asp Ser Ser 
    130                 135                 140                 


Pro Ala Ala Val Pro Val Val Ser Ser Ala Pro Val Pro Ser Asn Pro 
145                 150                 155                 160 


Asp Leu Gly Asp Ser Ala Phe Ser Met Glu Ser Cys Glu Asp Tyr Val 
                165                 170                 175     


Asn Val Pro Glu Ser Glu Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser 
            180                 185                 190         


Arg Glu Tyr Val Asn Val Ser Gln Asp Ala Gln Pro Val Ile Arg Ala 
        195                 200                 205             


Glu Leu Ala Ser Val Thr Ser Gln Glu Val Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Asp Val Asp Gly Glu Glu Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu 
225                 230                 235                 240 


Asn 
    


<210>  18
<211>  233
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  18

Met Glu Val Asn Val Leu Gly His Ser Ala Leu Gly Leu Leu Leu Gly 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Arg 
            20                  25                  30          


Leu Ser Asp Ser Tyr Asn Ser Ala Ser Ser Ser Asp Gly Leu Tyr Pro 
        35                  40                  45              


Arg Ser Ile Leu Ile Lys Pro Pro Tyr Thr Pro Ala Pro Trp Pro Ala 
    50                  55                  60                  


Val Thr Ser Val Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile Pro 
65                  70                  75                  80  


Arg Ser Pro Gln Pro Pro Gly Asp Ser His Arg Met Pro Ser Ser Arg 
                85                  90                  95      


Arg Asp Ser Gly Gly Ala Gln Ser Val Ala Ser Tyr Glu Asn Glu Glu 
            100                 105                 110         


Leu Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Glu Glu Asp Ser His 
        115                 120                 125             


Asn Glu Gly Tyr Leu Glu Val Leu Pro Asp Asp Ser Pro Ala Thr Ser 
    130                 135                 140                 


Gly Pro Gly Pro Ser Ala Pro Ala Pro Gly Asn Pro Gly Leu Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Gly Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Gly Ser Ala Asp Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu Pro Leu Glu Ala Arg Ile Gln Pro Ala Thr 
        195                 200                 205             


Leu Ser Ala Pro Glu Ala Gly Asp Gln Glu Glu Asp Glu Glu Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Gly Leu Asn 
225                 230             


<210>  19
<211>  261
<212>  PRT
<213>  Felis catus

<400>  19

Met Ile Ser Cys Pro Arg Pro Gly Ser Pro Gln Leu Pro Ala Thr Gly 
1               5                   10                  15      


Gly Gln Ala Leu Arg Arg Ser Arg Arg Leu Ala Glu Arg Gln Met Glu 
            20                  25                  30          


Ala Val Val Leu Ile Pro Tyr Val Leu Gly Leu Leu Leu Leu Pro Leu 
        35                  40                  45              


Leu Ala Val Val Leu Cys Val Arg Cys Arg Glu Leu Pro Gly Ser Tyr 
    50                  55                  60                  


Asp Asn Thr Ala Ser Asp Ser Leu Ala Pro Ser Ser Ile Val Ile Lys 
65                  70                  75                  80  


Arg Pro Pro Thr Leu Ala Thr Trp Thr Pro Ala Thr Ser Tyr Pro Pro 
                85                  90                  95      


Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile Pro 
            100                 105                 110         


Arg Ser Pro Gln Pro Pro Gly Gly Ser His Arg Met Pro Ser Ser Arg 
        115                 120                 125             


Gln Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Glu 
    130                 135                 140                 


Pro Ala Cys Glu Asp Asp Asp Glu Asp Glu Glu Glu Asp Tyr Pro Asn 
145                 150                 155                 160 


Glu Gly Tyr Leu Glu Val Leu Pro Asp Ser Thr Pro Ala Thr Gly Thr 
                165                 170                 175     


Ala Val Pro Pro Ala Pro Ala Pro Ser Asn Pro Gly Leu Arg Asp Ser 
            180                 185                 190         


Ala Phe Ser Met Glu Ser Gly Glu Asp Tyr Val Asn Val Pro Glu Ser 
        195                 200                 205             


Glu Glu Ser Ala Asp Val Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn 
    210                 215                 220                 


Val Ser Gln Glu Leu Pro Pro Val Ala Arg Thr Glu Pro Ala Ile Leu 
225                 230                 235                 240 


Ser Ser Gln Asn Asp Asp Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn 
                245                 250                 255     


Leu Gln Gly Leu Asn 
            260     


<210>  20
<211>  227
<212>  PRT
<213>  Odobenus rosmarus divergens

<400>  20

Met Glu Ala Val Val Leu Ile Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Gly Ala Leu Cys Val Arg Cys Arg Glu Leu Pro Gly 
            20                  25                  30          


Ser Tyr Asp Thr Thr Ala Ser Asp Ser Leu Thr Pro Ser Ser Ile Val 
        35                  40                  45              


Leu Lys Arg Pro Pro Thr Val Val Pro Trp Pro Ser Ala Thr Ser Tyr 
    50                  55                  60                  


Ala Pro Val Thr Ser Tyr Pro Ser Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro His His Val Pro Ser Ser Arg Gln Asp 
                85                  90                  95      


Ser Glu Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Glu Pro Val 
            100                 105                 110         


Cys Glu Asp Glu Glu Glu Glu Asp Glu Asp Tyr His Asn Glu Gly Tyr 
        115                 120                 125             


Leu Glu Val Leu Pro Asp Ser Thr Pro Ala Pro Ser Ser Ala Val Pro 
    130                 135                 140                 


Pro Ala Pro Val Leu Ser Asn Pro Gly Leu Arg Asp Ser Ala Phe Ser 
145                 150                 155                 160 


Met Glu Ser Gly Glu Asp Tyr Val Asn Val Leu Glu Ser Glu Glu Ser 
                165                 170                 175     


Ala Asp Val Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln 
            180                 185                 190         


Glu Leu Pro Pro Met Ala Lys Thr Glu Pro Ala Ile Leu Ser Ser Gln 
        195                 200                 205             


Lys Val Glu Asp Glu Asp Asp Glu Glu Glu Glu Gly Ala Pro Asp Tyr 
    210                 215                 220                 


Glu Asn Leu 
225         


<210>  21
<211>  231
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  21

Met Glu Val Val Val Leu Ile Pro Tyr Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Ala Leu Cys Val Arg Cys Arg Glu Met Pro Gly 
            20                  25                  30          


Ser Tyr Asp Thr Gly Ala Ser Asp Ser Leu Thr Pro Ser Ile Val Leu 
        35                  40                  45              


Lys Arg Pro Pro Thr Val Val Pro Trp Pro Ser Ala Thr Ser Tyr Ala 
    50                  55                  60                  


Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile 
65                  70                  75                  80  


Pro Arg Ser Pro Gln Pro His Arg Met Pro Ser Ser Arg Gln Asp Ser 
                85                  90                  95      


Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Glu Pro Val Cys 
            100                 105                 110         


Glu Asp Asp Asp Glu Asp Glu Glu Asp Tyr His Asn Glu Gly Tyr Leu 
        115                 120                 125             


Glu Val Leu Pro Asp Ser Thr Pro Thr Thr Ser Thr Ala Val Ala Pro 
    130                 135                 140                 


Ala Pro Val Pro Ser Asn Pro Gly Leu Arg Asp Ser Ala Phe Ser Met 
145                 150                 155                 160 


Glu Ser Gly Glu Asp Tyr Val Asn Val Ala Glu Ser Glu Glu Ser Ala 
                165                 170                 175     


Asn Val Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu 
            180                 185                 190         


Leu Pro Pro Met Ala Arg Thr Gln Pro Ala Ile Leu Asn Ser Gln Lys 
        195                 200                 205             


Leu Glu Asp Glu Asp Asp Glu Glu Glu Glu Glu Gly Ala Pro Asp Tyr 
    210                 215                 220                 


Glu Asn Leu Gln Gly Leu His 
225                 230     


<210>  22
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210>  23
<211>  279
<212>  PRT
<213>  Ovis aries

<400>  23

Met Glu Ala Val Ser Leu Pro Val Tyr Val Leu Gly Pro Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Asp Ala Glu Ser Pro Ile Leu His His Pro Leu Pro Ser Ser 
        35                  40                  45              


Pro Ser Phe Pro Ala Ser Arg Ala Leu Ser Ser Pro Gly Ser Tyr Asp 
    50                  55                  60                  


Thr Ala Val Ser Asp Ser Leu Thr Pro Ser Ser Ile Met Ile Lys Leu 
65                  70                  75                  80  


Pro Pro Thr Leu Val Pro Arg Pro Ser Thr Thr Pro Tyr Pro Leu Pro 
                85                  90                  95      


Ser Gln Pro Asp Leu Leu Pro Ile Pro Ser Pro Gln Pro Leu Gly Gly 
            100                 105                 110         


Ser His Arg Met Ala Ser Ser Arg Gln Asp Ser Asp Ser Ala Asn Ser 
        115                 120                 125             


Val Ala Ser Tyr Glu Asn Glu Gly Val Thr Gly Thr Pro Val Ala Pro 
    130                 135                 140                 


Ala Gly Arg Arg Leu Arg Pro Val Leu Gly Ser Ala Asp Pro Val Ser 
145                 150                 155                 160 


Leu Pro Pro Glu Ala Ala Cys Glu Asp Ala Asp Glu Asp Asp Tyr Asp 
                165                 170                 175     


Glu Asp Tyr Asn Asn Glu Gly Tyr Leu Val Val Leu Pro Asp Arg Asp 
            180                 185                 190         


Pro Ala Thr Ser Thr Gly Asn Ala Val Ser Pro Ala Pro Ala Pro Ser 
        195                 200                 205             


Lys Pro Gly Leu Arg Asp Ser Ala Phe Ser Met Glu Ser Gly Glu Asp 
    210                 215                 220                 


Tyr Val Asn Val Pro Glu Ser Glu Glu Ser Ala Asp Ala Ser Leu Asn 
225                 230                 235                 240 


Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu Leu Gln Pro Gly Ala 
                245                 250                 255     


Lys Thr Lys Pro Asp Thr Gln Asn Ser Gln Glu Val Glu Asp Glu Glu 
            260                 265                 270         


Ala Pro Asp Tyr Glu Asn Leu 
        275                 


<210>  24
<211>  254
<212>  PRT
<213>  Bos taurus

<400>  24

Met Glu Ala Val Ser Pro Ala Val Tyr Val Leu Gly Pro Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Gly Ser Tyr Asp Thr Ala Val Ser Asp Ser Leu Thr Pro Ser 
        35                  40                  45              


Ser Ile Met Ile Lys Leu Pro Pro Thr Leu Val Pro Arg Pro Ser Thr 
    50                  55                  60                  


Thr Pro Tyr Pro Leu Pro Ser Gln Pro Asp Leu Leu Pro Ile Pro Arg 
65                  70                  75                  80  


Ser Pro Gln Pro Leu Gly Gly Ser His Cys Met Ala Ser Ser Arg Gln 
                85                  90                  95      


Asp Ser Ala Ser Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Gly Val 
            100                 105                 110         


Thr Gly Thr Pro Val Ala Pro Ala Gly Arg Arg Leu Arg Pro Ile Leu 
        115                 120                 125             


Gly Ser Ala Asp Pro Val Trp Ser Pro Pro Glu Ala Ala Cys Glu Asp 
    130                 135                 140                 


Ala Asp Glu Asp Asp Tyr Glu Glu Asp Tyr Asn Asn Glu Gly Tyr Leu 
145                 150                 155                 160 


Val Val Leu Pro Asp Arg Asp Pro Ala Thr Ser Thr Gly Asn Ala Val 
                165                 170                 175     


Ser Pro Ala Pro Ala Ser Ser Lys Pro Gly Leu Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Gly Glu Asp Tyr Val Asn Val Pro Glu Ser Glu Glu 
        195                 200                 205             


Ser Ala Asp Ala Ser Leu Asn Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu Gln Pro Gly Ala Lys Thr Lys Pro Asp Thr Gln Asn Ser 
225                 230                 235                 240 


Gln Glu Val Glu Asp Glu Glu Ala Pro Asp Tyr Glu Asn Leu 
                245                 250                 


<210>  25
<211>  254
<212>  PRT
<213>  Capra hircus

<400>  25

Met Glu Ala Val Ser Leu Pro Val Tyr Val Leu Gly Pro Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Gly Ser Tyr Asp Thr Ala Val Ser Asp Ser Leu Thr Pro Ser 
        35                  40                  45              


Ser Ile Met Ile Lys Leu Pro Pro Thr Leu Val Pro Arg Pro Ser Thr 
    50                  55                  60                  


Thr Pro Tyr Pro Leu Pro Ser Gln Pro Asp Leu Leu Pro Ile Pro Arg 
65                  70                  75                  80  


Ser Pro Gln Pro Leu Gly Gly Ser His Arg Met Ala Ser Ser Arg Gln 
                85                  90                  95      


Asp Ser Asp Ser Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Gly Val 
            100                 105                 110         


Thr Gly Thr Pro Val Ala Pro Ala Gly Arg Arg Leu Arg Pro Val Leu 
        115                 120                 125             


Gly Ser Ala Asp Pro Val Ser Leu Pro Pro Glu Ala Ala Cys Glu Asp 
    130                 135                 140                 


Ala Asp Glu Asp Asp Tyr Asp Glu Asp Tyr Asn Asn Glu Gly Tyr Leu 
145                 150                 155                 160 


Val Val Leu Pro Asp Arg Asp Pro Ala Thr Ser Thr Gly Asn Ala Val 
                165                 170                 175     


Ser Pro Ala Pro Ala Ser Ser Lys Pro Gly Leu Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Gly Glu Asp Tyr Val Asn Val Pro Glu Ser Glu Glu 
        195                 200                 205             


Ser Ala Glu Ala Ser Leu Asn Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu Gln Pro Gly Ala Lys Thr Lys Pro Asp Thr Gln Asn Ser 
225                 230                 235                 240 


Gln Glu Val Glu Asp Glu Glu Ala Pro Asp Tyr Glu Asn Leu 
                245                 250                 


<210>  26
<211>  236
<212>  PRT
<213>  Orycteropus afer afer

<400>  26

Met Glu Ala Ala Val Leu Val Ser Thr Val Leu Gly Leu Leu Leu Met 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Thr Val Leu Cys Ala Arg Cys Arg Glu 
            20                  25                  30          


Met Pro Gly Ser Tyr Asp Ser Ala Ser Ser Asp Gly Leu Tyr Pro Ser 
        35                  40                  45              


Asn Ile Leu Ile Lys Arg Pro Tyr Thr Val Ala His Cys Pro Pro Ala 
    50                  55                  60                  


Thr Ser Tyr Pro Pro Val Ala Cys His Pro Pro Leu Ser Gln Pro Asp 
65                  70                  75                  80  


Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Pro Gly Ser Ser His Arg 
                85                  90                  95      


Ile Pro Pro Ser Gln Gln Asp Ser Asp Gly Ala Asn Ser Val Ala Ser 
            100                 105                 110         


Tyr Glu Asn Gln Glu Pro Ala Cys Glu Asp Thr Asp Gly Asp Glu Asp 
        115                 120                 125             


Glu Glu Asp Tyr His Asn Gly Arg Tyr Leu Val Val Leu Pro Asp Ser 
    130                 135                 140                 


Ser Pro Ala Ser Ser Thr Ala Val Pro Ser Ala Pro Ala Pro Ser Lys 
145                 150                 155                 160 


Ser Gly Leu Arg Asp Ser Ala Phe Ser Met Glu Ser Gly Asp Glu Tyr 
                165                 170                 175     


Val Asn Val Pro Glu Ser Glu Glu Ser Ala Glu Ala Ser Leu Asp Gly 
            180                 185                 190         


Ser Arg Glu Tyr Val Asn Val Ser Gln Glu Leu Gln Pro Val Ala Arg 
        195                 200                 205             


Thr Glu Thr Ala Thr Pro Ser Ser Gln Glu Val Glu Asp Glu Glu Glu 
    210                 215                 220                 


Gly Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230                 235     


<210>  27
<211>  260
<212>  PRT
<213>  Orcinus orca

<400>  27

Met Glu Ala Gly Ser Leu Val Leu Phe Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Gly Ser Tyr Asp Thr Ala Ala Ser Asp Gly Leu Thr Pro Ser 
        35                  40                  45              


Ser Ile Val Ile Lys Pro Pro Pro Thr Ala Ala Ser Trp Pro Pro Ala 
    50                  55                  60                  


Thr Ser Tyr Pro Pro Val Thr Tyr Leu Leu Gln Ser Gln Pro Asp Leu 
65                  70                  75                  80  


Leu Arg Ile Pro Arg Ser Pro Gln Ala Pro Gly Gly Ser Pro Arg Met 
                85                  90                  95      


Pro Ser Ser Gln Gln Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr 
            100                 105                 110         


Glu Asn Glu Gly Ala Ser Gly Ala Pro Ala Ala Leu Val Gly Arg Arg 
        115                 120                 125             


Leu Gly Pro Val Leu Gly Ser Ala Asp Pro Val Ser Leu Pro Thr Pro 
    130                 135                 140                 


Glu Ala Val Cys Glu Asp Ala Asp Glu Asp Glu Asp Glu Glu Asp Tyr 
145                 150                 155                 160 


Pro Glu Gly Tyr Leu Val Val Leu Pro Asp Asn Val Pro Ala Thr Gly 
                165                 170                 175     


Ala Ala Val Pro Pro Ala Pro Ala Ser Ser Asn Pro Gly Leu Arg Asp 
            180                 185                 190         


Ser Ala Phe Ser Met Glu Ser Gly Glu Asp Tyr Val Asn Val Pro Glu 
        195                 200                 205             


Ser Glu Glu Ser Ala Asp Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
    210                 215                 220                 


Asn Val Ser Gln Glu Leu Pro Pro Val Ala Arg Thr Glu Pro Ala Gly 
225                 230                 235                 240 


Arg Ser Ser Gln Glu Val Glu Gly Glu Glu Ala Pro Asp Tyr Glu Asn 
                245                 250                 255     


Leu Gln Ile His 
            260 


<210>  28
<211>  233
<212>  PRT
<213>  Sus scrofa

<400>  28

Met Glu Ala Val Ser Leu Ile Pro Tyr Ala Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Gly Ser Tyr Asp Thr Ala Ala Pro Asp Ser Leu Thr Pro Ser 
        35                  40                  45              


Ser Ile Val Ile Lys Arg Pro Pro Thr Leu Ala Pro Trp Pro Pro Ala 
    50                  55                  60                  


Thr Ser Tyr Pro Pro Met Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp 
65                  70                  75                  80  


Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Pro Gly Gly Ser His Arg 
                85                  90                  95      


Met Pro Ser Ser Arg Gln Asp Ser Asp Gly Ala Asn Ser Val Ala Ser 
            100                 105                 110         


Tyr Glu Asn Glu Glu Pro Val Cys Glu Asp Ala Asp Glu Asp Glu Asp 
        115                 120                 125             


Glu Glu Asp Tyr His Asn Glu Gly Tyr Leu Val Val Leu Pro Asp Ser 
    130                 135                 140                 


Val Pro Ala Thr Gly Ala Thr Val Pro Ala Ala Pro Ala Ser Asn Lys 
145                 150                 155                 160 


Pro Gly Leu Arg Asp Ser Ala Phe Ser Met Glu Ser Gly Glu Asp Tyr 
                165                 170                 175     


Val Asn Val Pro Glu Ser Glu Glu Ser Ala Asp Ala Ser Leu Asn Gly 
            180                 185                 190         


Ser Arg Glu Tyr Val Asn Val Ser Gln Glu Leu Gln Pro Val Ala Lys 
        195                 200                 205             


Thr Lys Pro Ala Thr Val Arg Ser Gln Glu Val Glu Asp Glu Glu Ala 
    210                 215                 220                 


Pro Asp Tyr Glu Asn Leu Gln Leu Asn 
225                 230             


<210>  29
<211>  268
<212>  PRT
<213>  Ceratotherium simum simum


<220>
<221>  misc_feature
<222>  (261)..(261)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Met Glu Ala Ala Ile Leu Ile Pro Ser Val Leu Gly Pro Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Gly Ser Tyr Asp Ser Ala Ala Ser Asp Ser Leu Thr Pro Ser 
        35                  40                  45              


Ser Ile Val Ile Lys Arg Pro Pro Thr Leu Ala Pro Trp Pro Pro Ala 
    50                  55                  60                  


Ala Ser Tyr Pro Pro Val Thr Ser Phe Pro Pro Leu Ser Gln Pro Asp 
65                  70                  75                  80  


Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Pro Gly Gly Ser His Arg 
                85                  90                  95      


Met Pro Ser Ser Arg Gln Gly Ser Asp Gly Ala Asn Ser Val Ala Ser 
            100                 105                 110         


Tyr Glu Asn Glu Gly Ala Ser Gly Thr Pro Gly Ala Val Ala Arg Gly 
        115                 120                 125             


Arg Leu Arg Pro Ala Pro Gly Phe Ala Asp Pro Arg Val Val Thr Pro 
    130                 135                 140                 


Glu Pro Ala Cys Glu Gly Ala Asp Glu Asp Glu Asp Glu Glu Asp Cys 
145                 150                 155                 160 


His Asn Glu Gly Tyr Leu Val Val Leu Pro Asp Thr Val Pro Ala Thr 
                165                 170                 175     


Gly Thr Ala Ile Pro Pro Pro Pro Ala Ser Lys Asn Pro Gly Leu Arg 
            180                 185                 190         


Asp Ser Ala Phe Ser Met Glu Ser Gly Glu Asp Tyr Val Asn Val Pro 
        195                 200                 205             


Glu Ser Glu Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr 
    210                 215                 220                 


Val Asn Val Ser Gln Glu Leu Gln Pro Thr Ala Arg Pro Glu Pro Ala 
225                 230                 235                 240 


Ala Trp Arg Ala Arg Glu Ala Glu Asp Glu Glu Glu Gly Ala Pro Asp 
                245                 250                 255     


Tyr Glu Asn Leu Xaa Glu Leu Asn Arg Glu Pro Val 
            260                 265             


<210>  30
<211>  238
<212>  PRT
<213>  Equus caballus

<400>  30

Met Glu Ala Ala Ile Leu Ile Pro Ser Val Leu Gly Pro Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Ala Val Leu Leu Met Ala Leu Cys Val Arg Cys Arg Glu 
            20                  25                  30          


Leu Pro Gly Ser Tyr Asp Ser Ala Ala Thr Asp Ser Leu Thr Pro Ser 
        35                  40                  45              


Ser Ile Val Ile Lys Arg Pro Pro Thr Leu Val Pro Trp Pro Pro Ala 
    50                  55                  60                  


Thr Ser Tyr Pro Pro Val Thr Ser Phe Pro Pro Leu Ser Gln Pro Asp 
65                  70                  75                  80  


Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Pro Gly Gly Ser His His 
                85                  90                  95      


Met Pro Ser Ser Arg Gln Gly Ser Asp Gly Ala Asn Ser Val Ala Ser 
            100                 105                 110         


Tyr Glu Asn Glu Glu Pro Val Cys Glu Asp Ala Glu Asp Asp Glu Asp 
        115                 120                 125             


Glu Glu Asp Tyr His Asn Glu Gly Tyr Leu Val Val Leu Pro Asp Pro 
    130                 135                 140                 


Ala Pro Thr Thr Thr Ala Ser Thr Val Val Pro Pro Ala Pro Val Ser 
145                 150                 155                 160 


Lys Asn Pro Gly Leu Arg Asp Ser Ala Phe Ser Met Glu Ser Gly Glu 
                165                 170                 175     


Asp Tyr Val Asn Val Pro Glu Ser Glu Glu Ser Ala Asp Ala Ser Leu 
            180                 185                 190         


Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu Leu Gln Pro Thr 
        195                 200                 205             


Ala Arg Thr Glu Pro Ala Thr Arg Lys Ala Gln Arg Val Glu Asp Glu 
    210                 215                 220                 


Glu Glu Gly Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230                 235             


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAT amino acid sequence (pY171-LAT)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  phosphorylated tyrosine

<400>  31

Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser 
1               5                   10                  15      


Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAT amino acid sequence (2pY-LAT)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  phosphorylated tyrosine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  phosphorylated tyrosine

<400>  32

Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser 
1               5                   10                  15      


Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu 
            20                  25                  


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  33

Pro Gly Asp Phe 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  34

Met Arg Asp Thr 
1               


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  35

Ala Ser Gln Ser Ser Pro Gly Asp Phe 
1               5                   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  36

Val Met Arg Asp Thr 
1               5   


<210>  37
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser Arg His Gln Ala Glu 
1               5                   10                  15      


Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe Ile Ile Arg Ala Ser 
            20                  25                  30          


Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val Arg His Glu Asp Asp 
        35                  40                  45              


Val Gln His Phe Lys Val Met Arg Asp Asn Lys Gly Asn Tyr Phe Leu 
    50                  55                  60                  


Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu Val Asp Tyr Tyr Arg 
65                  70                  75                  80  


Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe Leu Arg Asp Arg Thr 
                85                  90                  95      


Arg Glu Asp Gln 
            100 


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  38

Met Arg Asp Asn 
1               


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  39

Pro Gly Asp Phe Gly Val Met Arg Asp 
1               5                   


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  40

Pro Gly Asp Phe Gly Gly Val Met Arg Asp 
1               5                   10  


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  41

Pro Gly Asp Phe Pro Val Met Arg Asp 
1               5                   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  42

Val Met Arg Asp Asn 
1               5   


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short synthetic peptide

<400>  43

Ala Ser Gln Ser Ser Pro Gly Asp Phe Gly Val Met Arg Asp 
1               5                   10                  


<210>  44
<211>  3541
<212>  DNA
<213>  Homo sapiens

<400>  44
gatgatgaaa ggagaaggga aaggctgcgg atggccttca tttcctgctc ctggcatctg       60

gggattccga gaatgatccc aggacctaga tcctatagat tccggcagct cttcctgcaa      120

acacaagccc ttgttgtgtg cctgagcctt gctctccggc ctggagacat ccatctgccc      180

actctcctag gaactgctga ttaccaggaa gcaccatcgg ctctgctgcc ctccccctgg      240

cagagaggca caatgaccac attatttctc ttccagcttc acgttacagc atggaagctg      300

ttgccaagtt tgatttcact gcttcaggtg aggatgaact gagctttcac actggagatg      360

ttttgaagat tttaagtaac caagaggagt ggtttaaggc ggagcttggg agccaggaag      420

gatatgtgcc caagaatttc atagacatcc agtttcccaa atggtttcac gaaggcctct      480

ctcgacacca ggcagagaac ttactcatgg gcaaggaggt tggcttcttc atcatccggg      540

ccagccagag ctccccaggg gacttctcca tctctgtcag gcatgaggat gacgttcaac      600

acttcaaggt catgcgagac aacaagggta attactttct gtggactgag aagtttccat      660

ccctaaataa gctggtagac tactacagga caaattccat ctccagacag aagcagatct      720

tccttagaga cagaacccga gaagaccagg gtcaccgggg caacagcctg gaccggaggt      780

cccagggagg cccacacctc agtggggctg tgggagaaga aatccgacct tcgatgaacc      840

ggaagctgtc ggatcacccc ccgacccttc ccctgcagca gcaccagcac cagccacagc      900

ctccgcaata tgccccagcg ccccagcagc tgcagcagcc cccacagcag cgatatctgc      960

agcaccacca tttccaccag gaacgccgag gaggcagcct tgacataaat gatgggcatt     1020

gtggcaccgg cttgggcagt gaaatgaatg cggccctcat gcatcggaga cacacagacc     1080

cagtgcagct ccaggcggca gggcgagtgc ggtgggcccg ggcgctgtat gactttgagg     1140

ccctggagga tgacgagctg gggttccaca gcggggaggt ggtggaggtc ctggatagct     1200

ccaacccatc ctggtggacc ggccgcctgc acaacaagct gggcctcttc cctgccaact     1260

acgtggcacc catgacccga taaactcttc aggggacaga agctttttgt ctggagctgc     1320

ccacaagaaa gagggcaagg aaaaaaggct ggactccatg actatatata catacatcta     1380

tctacatctg cctgtgtaca cacacaactt tttatactag taatttattg gcaattgggc     1440

tggtaattag ttgatgcaaa agggaactca ggtggagaat aatattgaca cttgcttttc     1500

tgcccccctc aggggtgtgt ggaaggcagt gggggagttg ggaggggggc agggaaatga     1560

aatggagttt tgtcctggcc ttcagctgtc actgcttcct ccttgtcttg ggaattttca     1620

cggagaacag ctaagcagag accacacctc ggcactggac acagaacaac agggtggggt     1680

tgaacttggt ggggcacgtt ctagctgacc tgcaagcccc gctcacctgg agggcttgca     1740

gagcagctct cctcctgttc tccaaggggt gggcactgtt gcattaggaa ttaaggtgca     1800

gcccagtgct gcgggcagcc aagcgagtct gagcggggat gtgaaggcag gacggggttg     1860

gagagaccct gcctgtgcaa ggctggcctc ctagtcaaca cctagctgag acattcatct     1920

ctgttcaaat taatattcct tgggtctttc aaatgaatgt ttcaatgtga ggagcgaagt     1980

actgggaaat cgagggattt tccacaatcc ccaagcagct tactcagtgg aacctctgtt     2040

tccccagcta tgaaggaaat agcatcctac attccgtaaa gtgcttgaag aagctctagc     2100

tgagaatgct gaattttaca gtcattgttt tatggttaca agggtatgtc ttcagggctc     2160

tgttcatttt ccctcttgat tttctctttt gaagatgcct tgcccagtgg catggaaaga     2220

agcccacttg atgataggag cctgactatg aattgattga ctaaacatga ccccaggtgg     2280

aagctggctt tgacaccagc ttcctgttca gtctgaccac tgctgtcctc ctgctgccca     2340

agagttgcac ctggagcaag gaaccccacc atggctgtcg ctctccatcc catcacgcta     2400

gaatcatgtg tccaagggct cactctggag gtgcacagca caggtcagcc tggccagggg     2460

cgaaggagac agtagagagg aagctcaggg ccttagggga ggccgggtgc aaacccgttc     2520

tgcaccaagt gcactcggag tttgtgggta tgggtgtgta cccctgcagg tgtgcacatg     2580

tgtgcttgca cgcacatatt tgtgcactcc tgtgtgtata catgtgtgct tgtgtatgca     2640

tatgtgtgca ttcctgcatg tgtggacatg tgcgtgcatg catctgtgtg tctgtgtgtg     2700

tgctgagaca ggaaaggggg tgaaagtgtt ggtgagggag cctggaagtt ttctcttccc     2760

caacctctct tgctctaagg agggatgggg ttgggggcag ccgttattga aggtgatcgg     2820

agaagaaaga ttttctgact cagaagtgac tgccagtgta gcacaagcag tgtcccttgt     2880

gactgtgatt ctacagttct ctgatcctca tgtttccttt agaggaaaga ggaaaaaagg     2940

aactctgtgg tgggtattgg gagggaaaag aaaatagcct ggtggaggca ggagggagtc     3000

gagtgtgagt aaggagcacc tgcagctttt ggaagtgaaa gcagagagag ggaaaggtag     3060

ctaagacatc caggaggatc aaggggcagc gtgagaggca cagggggagg aaagggagag     3120

ggtgagtggg gccagggaag agaacggtgt ggagttggtg ggcagatggt gcaggaggag     3180

ggctgggcag tggggagagg aagaatcaga gcagagaaac cgctgctgcg gaaggcaggg     3240

agcaaagaag cataaggaaa agaacaggag aaagaacaaa ggcagagaag acctcctcag     3300

ctattttggt gctaggtaat gtgaaatgct gcagtaaata aaagccataa gtaatgtttg     3360

attttacagt atttacaaac catatgcttt aaacagccca caaactccat ccagttgtct     3420

gatgatgtgg gaggaccagc tctagttaga cggaggtatg tgattcgatt ctggtggaga     3480

ctttgtgcct tgaaaggctt ctcaggaaag cagtaataaa acaaagtgtc cttgtttggc     3540

c                                                                     3541


<210>  45
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIS tag-SH2  domain amino acid sequence

<400>  45

Met His His His His His His Gly Ser Met Gln Phe Pro Lys Trp Phe 
1               5                   10                  15      


His Glu Gly Leu Ser Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys 
            20                  25                  30          


Glu Val Gly Phe Phe Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp 
        35                  40                  45              


Phe Ser Ile Ser Val Arg His Glu Asp Asp Val Gln His Phe Lys Val 
    50                  55                  60                  


Met Arg Asp Asn Lys Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro 
65                  70                  75                  80  


Ser Leu Asn Lys Leu Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg 
                85                  90                  95      


Gln Lys Gln Ile Phe Leu Arg Asp Arg Thr Arg Glu Asp Gln 
            100                 105                 110 


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAT amino acid sequence (

<400>  46

Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser 
1               5                   10                  15      


Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu 
            20                  25                  


<210>  47
<211>  1554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence (ORF) of the Gads "bait", encoding N-terminally 
       Ras-tagged full length Human Gads

<400>  47
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc       60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac      120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc      180

ctggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt      240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc      300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg      360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc      420

tacatcgaga cctcggccaa gacccggcag ggagtggagg atgccttcta cacgttggtg      480

cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc ctgatgagag tggccccggc      540

tgcatgagct gcaagtggat cctggaagct gttgccaagt ttgatttcac tgcttcaggt      600

gaggatgaac tgagctttca cactggagat gttttgaaga ttttaagtaa ccaagaggag      660

tggtttaagg cggagcttgg gagccaggaa ggatatgtgc ccaagaattt catagacatc      720

cagtttccca aatggtttca cgaaggcctc tctcgacacc aggcagagaa cttactcatg      780

ggcaaggagg ttggcttctt catcatccgg gccagccaga gctccccagg ggacttctcc      840

atctctgtca ggcatgagga tgacgttcaa cacttcaagg tcatgcgaga caacaagggt      900

aattactttc tgtggactga gaagtttcca tccctaaata agctggtaga ctactacagg      960

acaaattcca tctccagaca gaagcagatc ttccttagag acagaacccg agaagaccag     1020

ggtcaccggg gcaacagcct ggaccggagg tcccagggag gcccacacct cagtggggct     1080

gtgggagaag aaatccgacc ttcgatgaac cggaagctgt cggatcaccc cccgaccctt     1140

cccctgcagc agcaccagca ccagccacag cctccgcaat atgccccagc gccccagcag     1200

ctgcagcagc ccccacagca gcgatatctg cagcaccacc atttccacca ggaacgccga     1260

ggaggcagcc ttgacataaa tgatgggcat tgtggcaccg gcttgggcag tgaaatgaat     1320

gcggccctca tgcatcggag acacacagac ccagtgcagc tccaggcggc agggcgagtg     1380

cggtgggccc gggcgctgta tgactttgaa gccctggagg atgacgagct ggggttccac     1440

agcggggagg tggtggaggt cctggatagc tccaacccat cctggtggac cggccgcctg     1500

cacaacaagc tgggcctctt ccctgccaac tacgtggcac ccatgacccg ataa           1554


<210>  48
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence (ORF) of the Gads "prey", encoding N-terminally 
       myristoylated full length human

<400>  48
atggggagta gcaagagcaa gcctaaggac cccagccagc gccggtctag agaattccct       60

cggatcctgg aagctgttgc caagtttgat ttcactgctt caggtgagga tgaactgagc      120

tttcacactg gagatgtttt gaagatttta agtaaccaag aggagtggtt taaggcggag      180

cttgggagcc aggaaggata tgtgcccaag aatttcatag acatccagtt tcccaaatgg      240

tttcacgaag gcctctctcg acaccaggca gagaacttac tcatgggcaa ggaggttggc      300

ttcttcatca tccgggccag ccagagctcc ccaggggact tctccatctc tgtcaggcat      360

gaggatgacg ttcaacactt caaggtcatg cgagacaaca agggtaatta ctttctgtgg      420

actgagaagt ttccatccct aaataagctg gtagactact acaggacaaa ttccatctcc      480

agacagaagc agatcttcct tagagacaga acccgagaag accagggtca ccggggcaac      540

agcctggacc ggaggtccca gggaggccca cacctcagtg gggctgtggg agaagaaatc      600

cgaccttcga tgaaccggaa gctgtcggat caccccccga cccttcccct gcagcagcac      660

cagcaccagc cacagcctcc gcaatatgcc ccagcgcccc agcagctgca gcagccccca      720

cagcagcgat atctgcagca ccaccatttc caccaggaac gccgaggagg cagccttgac      780

ataaatgatg ggcattgtgg caccggcttg ggcagtgaaa tgaatgcggc cctcatgcat      840

cggagacaca cagacccagt gcagctccag gcggcagggc gagtgcggtg ggcccgggcg      900

ctgtatgact ttgaggccct ggaggatgac gagctggggt tccacagcgg ggaggtggtg      960

gaggtcctgg atagctccaa cccatcctgg tggaccggcc gcctgcacaa caagctgggc     1020

ctcttccctg ccaactacgt ggcacccatg acccgataa                            1059


<210>  49
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence (ORF) of the Gads "bait", encoding Gads deltaN 
       RRS (lacking the N-terminal SH3 domain)

<400>  49
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc       60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac      120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc      180

ctggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt      240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc      300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg      360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc      420

tacatcgaga cctcggccaa gacccggcag ggagtggagg atgccttcta cacgttggtg      480

cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc ctgatgagag tggccccggc      540

tgcatgagct gcaagtggat cctgcagttt cccaaatggt ttcacgaagg cctctctcga      600

caccaggcag agaacttact catgggcaag gaggttggct tcttcatcat ccgggccagc      660

cagagctccc caggggactt ctccatctct gtcaggcatg aggatgacgt tcaacacttc      720

aaggtcatgc gagacaacaa gggtaattac tttctgtgga ctgagaagtt tccatcccta      780

aataagctgg tagactacta caggacaaat tccatctcca gacagaagca gatcttcctt      840

agagacagaa cccgagaaga ccagggtcac cggggcaaca gcctggaccg gaggtcccag      900

ggaggcccac acctcagtgg ggctgtggga gaagaaatcc gaccttcgat gaaccggaag      960

ctgtcggatc accccccgac ccttcccctg cagcagcacc agcaccagcc acagcctccg     1020

caatatgccc cagcgcccca gcagctgcag cagcccccac agcagcgata tctgcagcac     1080

caccatttcc accaggaacg ccgaggaggc agccttgaca taaatgatgg gcattgtggc     1140

accggcttgg gcagtgaaat gaatgcggcc ctcatgcatc ggagacacac agacccagtg     1200

cagctccagg cggcagggcg agtgcggtgg gcccgggcgc tgtatgactt tgaagccctg     1260

gaggatgacg agctggggtt ccacagcggg gaggtggtgg aggtcctgga tagctccaac     1320

ccatcctggt ggaccggccg cctgcacaac aagctgggcc tcttccctgc caactacgtg     1380

gcacccatga cccgataa                                                   1398


<210>  50
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gads N-terminal SH3 domain amino acid sequence

<400>  50

Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu Leu 
1               5                   10                  15      


Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu Glu 
            20                  25                  30          


Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys Asn 
        35                  40                  45              


Phe Ile Asp Ile 
    50          


