                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  Compositions and Methods for inducing an immune response

<130>  P10449WO

<150>  GB1708444.3
<151>  2017-05-26

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1353
<212>  PRT
<213>  Betacoronavirus MERS virus

<400>  1

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser His Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Arg  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  2
<211>  30842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChAdOx2 vector

<400>  2
ccatcttcaa taatatacct caaacttttt gtgcgcgtta atatgcaaat gaggcgtttg       60

aatttgggga ggaagggcgg tgattggtcg agggatgagc gaccgttagg ggcggggcga      120

gtgacgtttt gatgacgtgg ttgcgaggag gagccagttt gcaagttctc gtgggaaaag      180

tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac      240

aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact      300

gaatgaggaa gtgaaaatct gagtaatttc gcgtttatgg cagggaggag tatttgccga      360

gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtgttt ttcacctaaa      420

tttccgcgta cggtgtcaaa gtccggtgtt tttacgcgat cgctagcgac atcgatcaca      480

agtttgtaca aaaaagctga acgagaaacg taaaatgata taaatatcaa tatattaaat      540

tagattttgc ataaaaaaca gactacataa tactgtaaaa cacaacatat ccagtcacta      600

tggcggccgc cgatttattc aacaaagcca cgttgtgtct caaaatctct gatgttacat      660

tgcacaagat aaaaatatat catcatgaac aataaaactg tctgcttaca taaacagtaa      720

tacaaggggt gttatgagcc atattcaacg ggaaacgtct tgctcgaggc cgcgattaaa      780

ttccaacatg gatgctgatt tatatgggta taaatgggct cgtgataatg tcgggcaatc      840

aggtgcgaca atctatcgat tgtatgggaa gcccgatgcg ccagagttgt ttctgaaaca      900

tggcaaaggt agcgttgcca atgatgttac agatgagatg gtcagactaa actggctgac      960

ggaatttatg cctcttccga ccatcaagca ttttatccgt actcctgatg atgcatggtt     1020

actcaccact gcgatccccg ggaaaacagc attccaggta ttagaagaat atcctgattc     1080

aggtgaaaat attgttgatg cgctggcagt gttcctgcgc cggttgcatt cgattcctgt     1140

ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctc gctcaggcgc aatcacgaat     1200

gaataacggt ttggttgatg cgagtgattt tgatgacgag cgtaatggct ggcctgttga     1260

acaagtctgg aaagaaatgc ataagctttt gccattctca ccggattcag tcgtcactca     1320

tggtgatttc tcacttgata accttatttt tgacgagggg aaattaatag gttgtattga     1380

tgttggacga gtcggaatcg cagaccgata ccaggatctt gccatcctat ggaactgcct     1440

cggtgagttt tctccttcat tacagaaacg gctttttcaa aaatatggta ttgataatcc     1500

tgatatgaat aaattgcagt ttcatttgat gctcgatgag tttttctaat cagaattggt     1560

taattggttg taacactggc acgcgtggat ccggcttact aaaagccaga taacagtatg     1620

cgtatttgcg cgctgatttt tgcggtataa gaatatatac tgatatgtat acccgaagta     1680

tgtcaaaaag aggtatgcta tgaagcagcg tattacagtg acagttgaca gcgacagcta     1740

tcagttgctc aaggcatata tgatgtcaat atctccggtc tggtaagcac aaccatgcag     1800

aatgaagccc gtcgtctgcg tgccgaacgc tggaaagcgg aaaatcagga agggatggct     1860

gaggtcgccc ggtttattga aatgaacggc tcttttgctg acgagaacag gggctggtga     1920

aatgcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt ttgtggatgt     1980

acagagtgat attattgaca cgcccgggcg acggatggtg atccccctgg ccagtgcacg     2040

tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg gggatgaaag     2100

ctggcgcatg atgaccaccg atatggccag tgtgccggtc tccgttatcg gggaagaagt     2160

ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga tgttctgggg     2220

aatataaatg tcaggctccc ttatacacag ccagtctgca ggtcgaccat agtgactgga     2280

tatgttgtgt tttacagtat tatgtagtct gttttttatg caaaatctaa tttaatatat     2340

tgatatttat atcattttac gtttctcgtt cagctttctt gtacaaagtg gtgatcgatt     2400

cgacagatcg cgatcgcaag tgagtagtgt tctggggcgg gggaggacct gcatgagggc     2460

cagaataact gaaatctgtg cttttctgtg tgttgcagca gcatgagcgg aagcggctcc     2520

tttgagggag gggtattcag cccttatctg acggggcgtc tcccctcctg ggcgggagtg     2580

cgtcagaatg tgatgggatc cacggtggac ggccggcccg tgcagcccgc gaactcttca     2640

accctgacct atgcaaccct gagctcttcg tcgttggacg cagctgccgc cgcagctgct     2700

gcatctgccg ccagcgccgt gcgcggaatg gccatgggcg ccggctacta cggcactctg     2760

gtggccaact cgagttccac caataatccc gccagcctga acgaggagaa gctgttgctg     2820

ctgatggccc agctcgaggc cttgacccag cgcctgggcg agctgaccca gcaggtggct     2880

cagctgcagg agcagacgcg ggccgcggtt gccacggtga aatccaaata aaaaatgaat     2940

caataaataa acggagacgg ttgttgattt taacacagag tctgaatctt tatttgattt     3000

ttcgcgcgcg gtaggccctg gaccaccggt ctcgatcatt gagcacccgg tggatctttt     3060

ccaggacccg gtagaggtgg gcttggatgt tgaggtacat gggcatgagc ccgtcccggg     3120

ggtggaggta gctccattgc agggcctcgt gctcgggggt ggtgttgtaa atcacccagt     3180

catagcaggg gcgcagggca tggtgttgca caatatcttt gaggaggaga ctgatggcca     3240

cgggcagccc tttggtgtag gtgtttacaa atctgttgag ctgggaggga tgcatgcggg     3300

gggagatgag gtgcatcttg gcctggatct tgagattggc gatgttaccg cccagatccc     3360

gcctggggtt catgttgtgc aggaccacca gcacggtgta tccggtgcac ttggggaatt     3420

tatcatgcaa cttggaaggg aaggcgtgaa agaatttggc gacgcctttg tgcccgccca     3480

ggttttccat gcactcatcc atgatgatgg cgatgggccc gtgggcggcg gcctgggcaa     3540

agacgtttcg ggggtcggac acatcatagt tgtggtcctg ggtgaggtca tcataggcca     3600

ttttaatgaa tttggggcgg agggtgccgg actgggggac aaaggtaccc tcgatcccgg     3660

gggcgtagtt cccctcacag atctgcatct cccaggcttt gagctcggag ggggggatca     3720

tgtccacctg cggggcgata aagaacacgg tttccggggc gggggagatg agctgggccg     3780

aaagcaagtt ccggagcagc tgggacttgc cgcagccggt ggggccgtag atgaccccga     3840

tgaccggctg caggtggtag ttgagggaga gacagctgcc gtcctcccgg aggagggggg     3900

ccacctcgtt catcatctcg cgcacgtgca tgttctcgcg caccagttcc gccaggaggc     3960

gctctccccc cagggatagg agctcctgga gcgaggcgaa gtttttcagc ggcttgagtc     4020

cgtcggccat gggcattttg gagagggttt gttgcaagag ttccaggcgg tcccagagct     4080

cggtgatgtg ctctacggca tctcgatcca gcagacctcc tcgtttcgcg ggttgggacg     4140

gctgcgggag tagggcacca gacgatgggc gtccagcgca gccagggtcc ggtccttcca     4200

gggtcgcagc gtccgcgtca gggtggtctc cgtcacggtg aaggggtgcg cgccgggctg     4260

ggcgcttgcg agggtgcgct tcaggctcat ccggctggtc gaaaaccgct cccgatcggc     4320

gccctgcgcg tcggccaggt agcaattgac catgagttcg tagttgagcg cctcggccgc     4380

gtggcctttg gcgcggagct tacctttgga agtctgcccg caggcgggac agaggaggga     4440

cttgagggcg tagagcttgg gggcgaggaa gacggactcg ggggcgtagg cgtccgcgcc     4500

gcagtgggcg cagacggtct cgcactccac gagccaggtg aggtcgggct ggtcggggtc     4560

aaaaaccagt ttcccgccgt tctttttgat gcgtttctta cctttggtct ccatgagctc     4620

gtgtccccgc tgggtgacaa agaggctgtc cgtgtccccg tagaccgact ttatgggccg     4680

gtcctcgagc ggtgtgccgc ggtcctcctc gtagaggaac cccgcccact ccgagacgaa     4740

agcccgggtc caggccagca cgaaggaggc cacgtgggac gggtagcggt cgttgtccac     4800

cagcgggtcc accttttcca gggtatgcaa acacatgtcc ccctcgtcca catccaggaa     4860

ggtgattggc ttgtaagtgt aggccacgtg accgggggtc ccggccgggg gggtataaaa     4920

gggtgcgggt ccctgctcgt cctcactgtc ttccggatcg ctgtccagga gcgccagctg     4980

ttggggtagg tattccctct cgaaggcggg catgacctcg gcactcaggt tgtcagtttc     5040

tagaaacgag gaggatttga tattgacggt gccggcggag atgcctttca agagcccctc     5100

gtccatctgg tcagaaaaga cgatcttttt gttgtcgagc ttggtggcga aggagccgta     5160

gagggcgttg gagaggagct tggcgatgga gcgcatggtc tggttttttt ccttgtcggc     5220

gcgctccttg gcggcgatgt tgagctgcac gtactcgcgc gccacgcact tccattcggg     5280

gaagacggtg gtcagctcgt cgggcacgat tctgacctgc cagccccgat tatgcagggt     5340

gatgaggtcc acactggtgg ccacctcgcc gcgcaggggc tcattagtcc agcagaggcg     5400

tccgcccttg cgcgagcaga aggggggcag ggggtccagc atgacctcgt cgggggggtc     5460

ggcatcgatg gtgaagatgc cgggcaggag gtcggggtca aagtagctga tggaagtggc     5520

cagatcgtcc agggcagctt gccattcgcg cacggccagc gcgcgctcgt agggactgag     5580

gggcgtgccc cagggcatgg gatgggtaag cgcggaggcg tacatgccgc agatgtcgta     5640

gacgtagagg ggctcctcga ggatgccgat gtaggtgggg tagcagcgcc ccccgcggat     5700

gctggcgcgc acgtagtcat acagctcgtg cgagggggcg aggagccccg ggcccaggtt     5760

ggtgcgactg ggcttttcgg cgcggtagac gatctggcgg aaaatggcat gcgagttgga     5820

ggagatggtg ggcctttgga agatgttgaa gtgggcgtgg ggcagtccga ccgagtcgcg     5880

gatgaagtgg gcgtaggagt cttgcagctt ggcgacgagc tcggcggtga ctaggacgtc     5940

cagagcgcag tagtcgaggg tctcctggat gatgtcatac ttgagctgtc ccttttgttt     6000

ccacagctcg cggttgagaa ggaactcttc gcggtccttc cagtactctt cgagggggaa     6060

cccgtcctga tctgcacggt aagagcctag catgtagaac tggttgacgg ccttgtaggc     6120

gcagcagccc ttctccacgg ggagggcgta ggcctgggcg gccttgcgca gggaggtgtg     6180

cgtgagggcg aaagtgtccc tgaccatgac cttgaggaac tggtgcttga agtcgatatc     6240

gtcgcagccc ccctgctccc agagctggaa gtccgtgcgc ttcttgtagg cggggttggg     6300

caaagcgaaa gtaacatcgt tgaagaggat cttgcccgcg cggggcataa agttgcgagt     6360

gatgcggaaa ggttggggca cctcggcccg gttgttgatg acctgggcgg cgagcacgat     6420

ctcgtcgaag ccgttgatgt tgtggcccac gatgtagagt tccacgaatc gcggacggcc     6480

cttgacgtgg ggcagtttct tgagctcctc gtaggtgagc tcgtcggggt cgctgagccc     6540

gtgctgctcg agcgcccagt cggcgagatg ggggttggcg cggaggaagg aagtccagag     6600

atccacggcc agggcggttt gcagacggtc ccggtactga cggaactgct gcccgacggc     6660

cattttttcg ggggtgacgc agtagaaggt gcgggggtcc ccgtgccagc gatcccattt     6720

gagctggagg gcgagatcga gggcgagctc gacgagccgg tcgtccccgg agagtttcat     6780

gaccagcatg aaggggacga gctgcttgcc gaaggacccc atccaggtgt aggtttccac     6840

atcgtaggtg aggaagagcc tttcggtgcg aggatgcgag ccgatgggga agaactggat     6900

ctcctgccac caattggagg aatggctgtt gatgtgatgg aagtagaaat gccgacggcg     6960

cgccgaacac tcgtgcttgt gtttatacaa gcggccacag tgctcgcaac gctgcacggg     7020

atgcacgtgc tgcacgagct gtacctgagt tcctttgacg aggaatttca gtgggaagtg     7080

gagtcgtggc gcctgcatct cgtgctgtac tacgtcgtgg tggtcggcct ggccctcttc     7140

tgcctcgatg gtggtcatgc tgacgagccc gcgcgggagg caggtccaga cctcggcgcg     7200

agcgggtcgg agagcgagga cgagggcgcg caggccggag ctgtccaggg tcctgagacg     7260

ctgcggagtc aggtcagtgg gcagcggcgg cgcgcggttg acttgcagga gtttttccag     7320

ggcgcgcggg aggtccagat ggtacttgat ctccaccgcg ccattggtgg cgacgtcgat     7380

ggcttgcagg gtcccgtgcc cctggggtgt gaccaccgtc ccccgtttct tcttgggcgg     7440

ctggggcgac gggggcggtg cctcttccat ggttagaagc ggcggcgagg acgcgcgccg     7500

ggcggcaggg gcggctcggg gcccggaggc aggggcggca ggggcacgtc ggcgccgcgc     7560

gcgggtaggt tctggtactg cgcccggaga agactggcgt gagcgacgac gcgacggttg     7620

acgtcctgga tctgacgcct ctgggtgaag gccacgggac ccgtgagttt gaacctgaaa     7680

gagagttcga cagaatcaat ctcggtatcg ttgacggcgg cctgccgcag gatctcttgc     7740

acgtcgcccg agttgtcctg gtaggcgatc tcggtcatga actgctcgat ctcctcctct     7800

tgaaggtctc cgcggccggc gcgctccacg gtggccgcga ggtcgttgga gatgcggccc     7860

atgagctgcg agaaggcgtt catgcccgcc tcgttccaga cgcggctgta gaccacgacg     7920

ccctcgggat cgccggcgcg catgaccacc tgggcgaggt tgagctccac gtggcgcgtg     7980

aagaccgcgt agttgcagag gcgctggtag aggtagttga gcgtggtggc gatgtgctcg     8040

gtgacgaaga aatacatgat ccagcggcgg agcggcatct cgctgacgtc gcccagcgcc     8100

tccaaacgtt ccatggcctc gtaaaagtcc acggcgaagt tgaaaaactg ggagttgcgc     8160

gccgagacgg tcaactcctc ctccagaaga cggatgagct cggcgatggt ggcgcgcacc     8220

tcgcgctcga aggcccccgg gagttcctcc acttcctctt cttcctcctc cactaacatc     8280

tcttctactt cctcctcagg cggcagtggt ggcgggggag ggggcctgcg tcgccggcgg     8340

cgcacgggca gacggtcgat gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc     8400

tcggtgacgg cgcgcccgtc ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc     8460

aggtggccgg gggggtcccc gttgggcagg gagagggcgc tgacgatgca tcttatcaat     8520

tgccccgtag ggactccgcg caaggacctg agcgtctcga gatccacggg atctgaaaac     8580

cgctgaacga aggcttcgag ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct     8640

ggcgggtcat gttggttggg agcggggcgg gcgatgctgc tggtgatgaa gttgaaatag     8700

gcggttctga gacggcggat ggtggcgagg agcaccaggt ctttgggccc ggcttgctgg     8760

atgcgcagac ggtcggccat gccccaggcg tggtcctgac acctggccag gtccttgtag     8820

tagtcctgca tgagccgctc cacgggcacc tcctcctcgc ccgcgcggcc gtgcatgcgc     8880

gtgagcccga agccgcgctg gggctggacg agcgccaggt cggcgacgac gcgctcggcg     8940

aggatggctt gctggatctg ggtgagggtg gtctggaagt catcaaagtc gacgaagcgg     9000

tggtaggctc cggtgttgat ggtgtaggag cagttggcca tgacggacca gttgacggtc     9060

tggtggcccg gacgcacgag ctcgtggtac ttgaggcgcg agtaggcgcg cgtgtcgaag     9120

atgtagtcgt tgcaggtgcg caccaggtac tggtagccga tgaggaagtg cggcggcggc     9180

tggcggtaga gcggccatcg ctcggtggcg ggggcgccgg gcgcgaggtc ctcgagcatg     9240

gtgcggtggt agccgtagat gtacctggac atccaggtga tgccggcggc ggtggtggag     9300

gcgcgcggga actcgcggac gcggttccag atgttgcgca gcggcaggaa gtagttcatg     9360

gtgggcacgg tctggcccgt gaggcgcgcg cagtcgtgga tgctctatac gggcaaaaac     9420

gaaagcggtc agcggctcga ctccgtggcc tggaggctaa gcgaacgggt tgggctgcgc     9480

gtgtaccccg gttcgaatct cgaatcaggc tggagccgca gctaacgtgg tattggcact     9540

cccgtctcga cccaagcctg caccaaccct ccaggatacg gaggcgggtc gttttgcaac     9600

ttttttttgg aggccggatg agactagtaa gcgcggaaag cggccgaccg cgatggctcg     9660

ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg gtgtgccccg gttcgaggcc     9720

ggccggattc cgcggctaac gagggcgtgg ctgccccgtc gtttccaaga ccccatagcc     9780

agccgacttc tccagttacg gagcgagccc ctcttttgtt ttgtttgttt ttgccagatg     9840

catcccgtac tgcggcagat gcgcccccac caccctccac cgcaacaaca gccccctcca     9900

cagccggcgc ttctgccccc gccccagcag caacttccag ccacgaccgc cgcggccgcc     9960

gtgagcgggg ctggacagag ttatgatcac cagctggcct tggaagaggg cgaggggctg    10020

gcgcgcctgg gggcgtcgtc gccggagcgg cacccgcgcg tgcagatgaa aagggacgct    10080

cgcgaggcct acgtgcccaa gcagaacctg ttcagagaca ggagcggcga ggagcccgag    10140

gagatgcgcg cggcccggtt ccacgcgggg cgggagctgc ggcgcggcct ggaccgaaag    10200

agggtgctga gggacgagga tttcgaggcg gacgagctga cggggatcag ccccgcgcgc    10260

gcgcacgtgg ccgcggccaa cctggtcacg gcgtacgagc agaccgtgaa ggaggagagc    10320

aacttccaaa aatccttcaa caaccacgtg cgcaccctga tcgcgcgcga ggaggtgacc    10380

ctgggcctga tgcacctgtg ggacctgctg gaggccatcg tgcagaaccc caccagcaag    10440

ccgctgacgg cgcagctgtt cctggtggtg cagcatagtc gggacaacga agcgttcagg    10500

gaggcgctgc tgaatatcac cgagcccgag ggccgctggc tcctggacct ggtgaacatt    10560

ctgcagagca tcgtggtgca ggagcgcggg ctgccgctgt ccgagaagct ggcggccatc    10620

aacttctcgg tgctgagttt gggcaagtac tacgctagga agatctacaa gaccccgtac    10680

gtgcccatag acaaggaggt gaagatcgac gggttttaca tgcgcatgac cctgaaagtg    10740

ctgaccctga gcgacgatct gggggtgtac cgcaacgaca ggatgcaccg tgcggtgagc    10800

gccagcaggc ggcgcgagct gagcgaccag gagctgatgc atagtctgca gcgggccctg    10860

accggggccg ggaccgaggg ggagagctac tttgacatgg gcgcggacct gcactggcag    10920

cccagccgcc gggccttgga ggcggcggca ggaccctacg tagaagaggt ggacgatgag    10980

gtggacgagg agggcgagta cctggaagac tgatggcgcg accgtatttt tgctagatgc    11040

aacaacaaca gccacctcct gatcccgcga tgcgggcggc gctgcagagc cagccgtccg    11100

gcattaactc ctcggacgat tggacccagg ccatgcaacg catcatggcg ctgacgaccc    11160

gcaaccccga agcctttaga cagcagcccc aggccaaccg gctctcggcc atcctggagg    11220

ccgtggtgcc ctcgcgctcc aaccccacgc acgagaaggt cctggccatc gtgaacgcgc    11280

tggtggagaa caaggccatc cgcggcgacg aggccggcct ggtgtacaac gcgctgctgg    11340

agcgcgtggc ccgctacaac agcaccaacg tgcagaccaa cctggaccgc atggtgaccg    11400

acgtgcgcga ggccgtggcc cagcgcgagc ggttccaccg cgagtccaac ctgggatcca    11460

tggtggcgct gaacgccttc ctcagcaccc agcccgccaa cgtgccccgg ggccaggagg    11520

actacaccaa cttcatcagc gccctgcgcc tgatggtgac cgaggtgccc cagagcgagg    11580

tgtaccagtc cgggccggac tacttcttcc agaccagtcg ccagggcttg cagaccgtga    11640

acctgagcca ggctttcaag aacttgcagg gcctgtgggg cgtgcaggcc ccggtcgggg    11700

accgcgcgac ggtgtcgagc ctgctgacgc cgaactcgcg cctgctgctg ctgctggtgg    11760

cccccttcac ggacagcggc agcatcaacc gcaactcgta cctgggctac ctgattaacc    11820

tgtaccgcga ggccatcggc caggcgcacg tggacgagca gacctaccag gagatcaccc    11880

acgtgagccg cgccctgggc caggacgacc cgggcaacct ggaagccacc ctgaactttt    11940

tgctgaccaa ccggtcgcag aagatcccgc cccagtacgc gctcagcacc gaggaggagc    12000

gcatcctgcg ttacgtgcag cagagcgtgg gcctgttcct gatgcaggag ggggccaccc    12060

ccagcgccgc gctcgacatg accgcgcgca acatggagcc cagcatgtac gccagcaacc    12120

gcccgttcat caataaactg atggactact tgcatcgggc ggccgccatg aactctgact    12180

atttcaccaa cgccatcctg aatccccact ggctcccgcc gccggggttc tacacgggcg    12240

agtacgacat gcccgacccc aatgacgggt tcctgtggga cgatgtggac agcagcgtgt    12300

tctccccccg accgggtgct aacgagcgcc ccttgtggaa gaaggaaggc agcgaccgac    12360

gcccgtcctc ggcgctgtcc ggccgcgagg gtgctgccgc ggcggtgccc gaggccgcca    12420

gtcctttccc gagcttgccc ttctcgctga acagtatccg cagcagcgag ctgggcagga    12480

tcacgcgccc gcgcttgctg ggcgaagagg agtacttgaa tgactcgctg ttgagacccg    12540

agcgggagaa gaacttcccc aataacggga tagaaagcct ggtggacaag atgagccgct    12600

ggaagacgta tgcgcaggag cacagggacg atccccgggc gtcgcagggg gccacgagcc    12660

ggggcagcgc cgcccgtaaa cgccggtggc acgacaggca gcggggacag atgtgggacg    12720

atgaggactc cgccgacgac agcagcgtgt tggacttggg tgggagtggt aacccgttcg    12780

ctcacctgcg cccccgtatc gggcgcatga tgtaagagaa accgaaaata aatgatactc    12840

accaaggcca tggcgaccag cgtgcgttcg tttcttctct gttgttgttg tatctagtat    12900

gatgaggcgt gcgtacccgg agggtcctcc tccctcgtac gagagcgtga tgcagcaggc    12960

gatggcggcg gcggcgatgc agcccccgct ggaggctcct tacgtgcccc cgcggtacct    13020

ggcgcctacg gaggggcgga acagcattcg ttactcggag ctggcaccct tgtacgatac    13080

cacccggttg tacctggtgg acaacaagtc ggcggacatc gcctcgctga actaccagaa    13140

cgaccacagc aacttcctga ccaccgtggt gcagaacaat gacttcaccc ccacggaggc    13200

cagcacccag accatcaact ttgacgagcg ctcgcggtgg ggcggccagc tgaaaaccat    13260

catgcacacc aacatgccca acgtgaacga gttcatgtac agcaacaagt tcaaggcgcg    13320

ggtgatggtc tcccgcaaga cccccaatgg ggtgacagtg acagaggatt atgatggtag    13380

tcaggatgag ctgaagtatg aatgggtgga atttgagctg cccgaaggca acttctcggt    13440

gaccatgacc atcgacctga tgaacaacgc catcatcgac aattacttgg cggtggggcg    13500

gcagaacggg gtgctggaga gcgacatcgg cgtgaagttc gacactagga acttcaggct    13560

gggctgggac cccgtgaccg agctggtcat gcccggggtg tacaccaacg aggctttcca    13620

tcccgatatt gtcttgctgc ccggctgcgg ggtggacttc accgagagcc gcctcagcaa    13680

cctgctgggc attcgcaaga ggcagccctt ccaggaaggc ttccagatca tgtacgagga    13740

tctggagggg ggcaacatcc ccgcgctcct ggatgtcgac gcctatgaga aaagcaagga    13800

ggatgcagca gctgaagcaa ctgcagccgt agctaccgcc tctaccgagg tcaggggcga    13860

taattttgca agcgccgcag cagtggcagc ggccgaggcg gctgaaaccg aaagtaagat    13920

agtcattcag ccggtggaga aggatagcaa gaacaggagc tacaacgtac taccggacaa    13980

gataaacacc gcctaccgca gctggtacct agcctacaac tatggcgacc ccgagaaggg    14040

cgtgcgctcc tggacgctgc tcaccacctc ggacgtcacc tgcggcgtgg agcaagtcta    14100

ctggtcgctg cccgacatga tgcaagaccc ggtcaccttc cgctccacgc gtcaagttag    14160

caactacccg gtggtgggcg ccgagctcct gcccgtctac tccaagagct tcttcaacga    14220

gcaggccgtc tactcgcagc agctgcgcgc cttcacctcg cttacgcacg tcttcaaccg    14280

cttccccgag aaccagatcc tcgtccgccc gcccgcgccc accattacca ccgtcagtga    14340

aaacgttcct gctctcacag atcacgggac cctgccgctg cgcagcagta tccggggagt    14400

ccagcgcgtg accgttactg acgccagacg ccgcacctgc ccctacgtct acaaggccct    14460

gggcatagtc gcgccgcgcg tcctctcgag ccgcaccttc taaatgtcca ttctcatctc    14520

gcccagtaat aacaccggtt ggggcctgcg cgcgcccagc aagatgtacg gaggcgctcg    14580

ccaacgctcc acgcaacacc ccgtgcgcgt gcgcgggcac ttccgcgctc cctggggcgc    14640

cctcaagggc cgcgtgcggt cgcgcaccac cgtcgacgac gtgatcgacc aggtggtggc    14700

cgacgcgcgc aactacaccc ccgccgccgc gcccgtctcc accgtggacg ccgtcatcga    14760

cagcgtggtg gcggacgcgc gccggtacgc ccgcgccaag agccggcggc ggcgcatcgc    14820

ccggcggcac cggagcaccc ccgccatgcg cgcggcgcga gccttgctgc gcagggccag    14880

gcgcacggga cgcagggcca tgctcagggc ggccagacgc gcggcttcag gcgccagcgc    14940

cggcaggacc cggagacgcg cggccacggc ggcggcagcg gccatcgcca gcatgtcccg    15000

cccgcggcga gggaacgtgt actgggtgcg cgacgccgcc accggtgtgc gcgtgcccgt    15060

gcgcacccgc ccccctcgca cttgaagatg ttcacttcgc gatgttgatg tgtcccagcg    15120

gcgaggagga tgtccaagcg caaattcaag gaagagatgc tccaggtcat cgcgcctgag    15180

atctacggcc ctgcggtggt gaaggaggaa agaaagcccc gcaaaatcaa gcgggtcaaa    15240

aaggacaaaa aggaagaaga aagtgatgtg gacggattgg tggagtttgt gcgcgagttc    15300

gccccccggc ggcgcgtgca gtggcgcggg cggaaggtgc aaccggtgct gagacccggc    15360

accaccgtgg tcttcacgcc cggcgagcgc tccggcaccg cttccaagcg ctcctacgac    15420

gaggtgtacg gggatgatga tattctggag caggcggccg agcgcctggg cgagtttgct    15480

tacggcaagc gcagccgttc cgcaccgaag gaagaggcgg tgtccatccc gctggaccac    15540

ggcaacccca cgccgagcct caagcccgtg accttgcagc aggtgctgcc gaccgcggcg    15600

ccgcgccggg ggttcaagcg cgagggcgag gatctgtacc ccaccatgca gctgatggtg    15660

cccaagcgcc agaagctgga agacgtgctg gagaccatga aggtggaccc ggacgtgcag    15720

cccgaggtca aggtgcggcc catcaagcag gtggccccgg gcctgggcgt gcagaccgtg    15780

gacatcaaga ttcccacgga gcccatggaa acgcagaccg agcccatgat caagcccagc    15840

accagcacca tggaggtgca gacggatccc tggatgccat cggctcctag tcgaagaccc    15900

cggcgcaagt acggcgcggc cagcctgctg atgcccaact acgcgctgca tccttccatc    15960

atccccacgc cgggctaccg cggcacgcgc ttctaccgcg gtcataccag cagccgccgc    16020

cgcaagacca ccactcgccg ccgccgtcgc cgcaccgccg ctgcaaccac ccctgccgcc    16080

ctggtgcgga gagtgtaccg ccgcggccgc gcacctctga ccctgccgcg cgcgcgctac    16140

cacccgagca tcgccattta aactttcgcc agctttgcag atcaatggcc ctcacatgcc    16200

gccttcgcgt tcccattacg ggctaccgag gaagaaaacc gcgccgtaga aggctggcgg    16260

ggaacgggat gcgtcgccac caccaccggc ggcggcgcgc catcagcaag cggttggggg    16320

gaggcttcct gcccgcgctg atccccatca tcgccgcggc gatcggggcg atccccggca    16380

ttgcttccgt ggcggtgcag gcctctcagc gccactgaga cacacttgga aacatcttgt    16440

aataaaccca tggactctga cgctcctggt cctgtgatgt gttttcgtag acagatggaa    16500

gacatcaatt tttcgtccct ggctccgcga cacggcacgc ggccgttcat gggcacctgg    16560

agcgacatcg gcaccagcca actgaacggg ggcgccttca attggagcag tctctggagc    16620

gggcttaaga atttcgggtc cacgcttaaa acctatggca gcaaggcgtg gaacagcacc    16680

acagggcagg cgctgaggga taagctgaaa gagcagaact tccagcagaa ggtggtcgat    16740

gggctcgcct cgggcatcaa cggggtggtg gacctggcca accaggccgt gcagcggcag    16800

atcaacagcc gcctggaccc ggtgccgccc gccggctccg tggagatgcc gcaggtggag    16860

gaggagctgc ctcccctgga caagcggggc gagaagcgac cccgccccga tgcggaggag    16920

acgctgctga cgcacacgga cgagccgccc ccgtacgagg aggcggtgaa actgggtctg    16980

cccaccacgc ggcccatcgc gcccctggcc accggggtgc tgaaacccga aaagcccgcg    17040

accctggact tgcctcctcc ccagccttcc cgcccctcta cagtggctaa gcccctgccg    17100

ccggtggccg tggcccgcgc gcgacccggg ggcaccgccc gccctcatgc gaactggcag    17160

agcactctga acagcatcgt gggtctggga gtgcagagtg tgaagcgccg ccgctgctat    17220

taaacctacc gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc    17280

cgctgtccac cagaaggagg agtgaagagg cgcgtcgccg agttgcaaga tggccacccc    17340

atcgatgctg ccccagtggg cgtacatgca catcgccgga caggacgctt cggagtacct    17400

gagtccgggt ctggtgcagt ttgcccgcgc cacagacacc tacttcagtc tggggaacaa    17460

gtttaggaac cccacggtgg cgcccacgca cgatgtgacc accgaccgca gccagcggct    17520

gacgctgcgc ttcgtgcccg tggaccgcga ggacaacacc tactcgtaca aagtgcgcta    17580

cacgctggcc gtgggcgaca accgcgtgct ggacatggcc agcacctact ttgacatccg    17640

cggcgtgctg gatcggggcc ctagcttcaa accctactcc ggcaccgcct acaacagtct    17700

ggcccccaag ggagcaccca acacttgtca gtggacatat aaagccgatg gtgaaactgc    17760

cacagaaaaa acctatacat atggaaatgc acccgtgcag ggcattaaca tcacaaaaga    17820

tggtattcaa cttggaactg acaccgatga tcagccaatc tacgcagata aaacctatca    17880

gcctgaacct caagtgggtg atgctgaatg gcatgacatc actggtactg atgaaaagta    17940

tggaggcaga gctcttaagc ctgataccaa aatgaagcct tgttatggtt cttttgccaa    18000

gcctactaat aaagaaggag gtcaggcaaa tgtgaaaaca ggaacaggca ctactaaaga    18060

atatgacata gacatggctt tctttgacaa cagaagtgcg gctgctgctg gcctagctcc    18120

agaaattgtt ttgtatactg aaaatgtgga tttggaaact ccagataccc atattgtata    18180

caaagcaggc acagatgaca gcagctcttc tattaatttg ggtcagcaag ccatgcccaa    18240

cagacctaac tacattggtt tcagagacaa ctttatcggg ctcatgtact acaacagcac    18300

tggcaatatg ggggtgctgg ccggtcaggc ttctcagctg aatgctgtgg ttgacttgca    18360

agacagaaac accgagctgt cctaccagct cttgcttgac tctctgggtg acagaacccg    18420

gtatttcagt atgtggaatc aggcggtgga cagctatgat cctgatgtgc gcattattga    18480

aaatcatggt gtggaggatg aacttcccaa ctattgtttc cctctggatg ctgttggcag    18540

aacagatact tatcagggaa ttaaggctaa tggaactgat caaaccacat ggaccaaaga    18600

tgacagtgtc aatgatgcta atgagatagg caagggtaat ccattcgcca tggaaatcaa    18660

catccaagcc aacctgtgga ggaacttcct ctacgccaac gtggccctgt acctgcccga    18720

ctcttacaag tacacgccgg ccaatgttac cctgcccacc aacaccaaca cctacgatta    18780

catgaacggc cgggtggtgg cgccctcgct ggtggactcc tacatcaaca tcggggcgcg    18840

ctggtcgctg gatcccatgg acaacgtgaa ccccttcaac caccaccgca atgcggggct    18900

gcgctaccgc tccatgctcc tgggcaacgg gcgctacgtg cccttccaca tccaggtgcc    18960

ccagaaattt ttcgccatca agagcctcct gctcctgccc gggtcctaca cctacgagtg    19020

gaacttccgc aaggacgtca acatgatcct gcagagctcc ctcggcaacg acctgcgcac    19080

ggacggggcc tccatctcct tcaccagcat caacctctac gccaccttct tccccatggc    19140

gcacaacacg gcctccacgc tcgaggccat gctgcgcaac gacaccaacg accagtcctt    19200

caacgactac ctctcggcgg ccaacatgct ctaccccatc ccggccaacg ccaccaacgt    19260

gcccatctcc atcccctcgc gcaactgggc cgccttccgc ggctggtcct tcacgcgtct    19320

caagaccaag gagacgccct cgctgggctc cgggttcgac ccctacttcg tctactcggg    19380

ctccatcccc tacctcgacg gcaccttcta cctcaaccac accttcaaga aggtctccat    19440

caccttcgac tcctccgtca gctggcccgg caacgaccgg ctcctgacgc ccaacgagtt    19500

cgaaatcaag cgcaccgtcg acggcgaggg ctacaacgtg gcccagtgca acatgaccaa    19560

ggactggttc ctggtccaga tgctggccca ctacaacatc ggctaccagg gcttctacgt    19620

gcccgagggc tacaaggacc gcatgtactc cttcttccgc aacttccagc ccatgagccg    19680

ccaggtggtg gacgaggtca actacaagga ctaccaggcc gtcaccctgg cctaccagca    19740

caacaactcg ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc agccctaccc    19800

cgccaactac ccctacccgc tcatcggcaa gagcgccgtc accagcgtca cccagaaaaa    19860

gttcctctgc gacagggtca tgtggcgcat ccccttctcc agcaacttca tgtccatggg    19920

cgcgctcacc gacctcggcc agaacatgct ctatgccaac tccgcccacg cgctagacat    19980

gaatttcgaa gtcgacccca tggatgagtc cacccttctc tatgttgtct tcgaagtctt    20040

cgacgtcgtc cgagtgcacc agccccaccg cggcgtcatc gaggccgtct acctgcgcac    20100

ccccttctcg gccggtaacg ccaccaccta agctcttgct tcttgcaagc catggccgcg    20160

ggctccggcg agcaggagct cagggccatc atccgcgacc tgggctgcgg gccctacttc    20220

ctgggcacct tcgataagcg cttcccggga ttcatggccc cgcacaagct ggcctgcgcc    20280

atcgtcaaca cggccggccg cgagaccggg ggcgagcact ggctggcctt cgcctggaac    20340

ccgcgctcga acacctgcta cctcttcgac cccttcgggt tctcggacga gcgcctcaag    20400

cagatctacc agttcgagta cgagggcctg ctgcgccgca gcgccctggc caccgaggac    20460

cgctgcgtca ccctggaaaa gtccacccag accgtgcagg gtccgcgctc ggccgcctgc    20520

gggctcttct gctgcatgtt cctgcacgcc ttcgtgcact ggcccgaccg ccccatggac    20580

aagaacccca ccatgaactt gctgacgggg gtgcccaacg gcatgctcca gtcgccccag    20640

gtggaaccca ccctgcgccg caaccaggag gcgctctacc gcttcctcaa ctcccactcc    20700

gcctactttc gctcccaccg cgcgcgcatc gagaaggcca ccgccttcga ccgcatgaat    20760

caagacatgt aaaccgtgtg tgtatgttaa atgtctttaa taaacagcac tttcatgtta    20820

cacatgcatc tgagatgatt tatttagaaa tcgaaagggt tctgccgggt ctcggcatgg    20880

cccgcgggca gggacacgtt gcggaactgg tacttggcca gccacttgaa ctcggggatc    20940

agcagtttgg gcagcggggt gtcggggaag gagtcggtcc acagcttccg cgtcagttgc    21000

agggcgccca gcaggtcggg cgcggagatc ttgaaatcgc agttgggacc cgcgttctgc    21060

gcgcgggagt tgcggtacac ggggttgcag cactggaaca ccatcagggc cgggtgcttc    21120

acgctcgcca gcaccgtcgc gtcggtgatg ctctccacgt cgaggtcctc ggcgttggcc    21180

atcccgaagg gggtcatctt gcaggtctgc cttcccatgg tgggcacgca cccgggcttg    21240

tggttgcaat cgcagtgcag ggggatcagc atcatctggg cctggtcggc gttcatcccc    21300

gggtacatgg ccttcatgaa agcctccaat tgcctgaacg cctgctgggc cttggctccc    21360

tcggtgaaga agaccccgca ggacttgcta gagaactggt tggtggcgca cccggcgtcg    21420

tgcacgcagc agcgcgcgtc gttgttggcc agctgcacca cgctgcgccc ccagcggttc    21480

tgggtgatct tggcccggtc ggggttctcc ttcagcgcgc gctgcccgtt ctcgctcgcc    21540

acatccatct cgatcatgtg ctccttctgg atcatggtgg tcccgtgcag gcaccgcagc    21600

ttgccctcgg cctcggtgca cccgtgcagc cacagcgcgc acccggtgca ctcccagttc    21660

ttgtgggcga tctgggaatg cgcgtgcacg aagccctgca ggaagcggcc catcatggtg    21720

gtcagggtct tgttgctagt gaaggtcagc ggaatgccgc ggtgctcctc gttgatgtac    21780

aggtggcaga tgcggcggta cacctcgccc tgctcgggca tcagctggaa gttggctttc    21840

aggtcggtct ccacgcggta gcggtccatc agcatagtca tgatttccat acccttctcc    21900

caggccgaga cgatgggcag gctcataggg ttcttcacca tcatcttagc gctagcagcc    21960

gcggccaggg ggtcgctctc gtccagggtc tcaaagctcc gcttgccgtc cttctcggtg    22020

atccgcaccg gggggtagct gaagcccacg gccgccagct cctcctcggc ctgtctttcg    22080

tcctcgctgt cctggctgac gtcctgcagg accacatgct tggtcttgcg gggtttcttc    22140

ttgggcggca gcggcggcgg agatgttgga gatggcgagg gggagcgcga gttctcgctc    22200

accactacta tctcttcctc ttcttggtcc gaggccacgc ggcggtaggt atgtctcttc    22260

gggggcagag gcggaggcga cgggctctcg ccgccgcgac ttggcggatg gctggcagag    22320

ccccttccgc gttcgggggt gcgctcccgg cggcgctctg actgacttcc tccgcggccg    22380

gccattgtgt tctcctaggg aggaacaaca agcatggaga ctcagccatc gccaacctcg    22440

ccatctgccc ccaccgccga cgagaagcag cagcagcaga atgaaagctt aaccgccccg    22500

ccgcccagcc ccgccacctc cgacgcggcc gtcccagaca tgcaagagat ggaggaatcc    22560

atcgagattg acctgggcta tgtgacgccc gcggagcacg aggaggagct ggcagtgcgc    22620

ttttcacaag aagagataca ccaagaacag ccagagcagg aagcagagaa tgagcagagt    22680

caggctgggc tcgagcatga cggcgactac ctccacctga gcggggggga ggacgcgctc    22740

atcaagcatc tggcccggca ggccaccatc gtcaaggatg cgctgctcga ccgcaccgag    22800

gtgcccctca gcgtggagga gctcagccgc gcctacgagt tgaacctctt ctcgccgcgc    22860

gtgcccccca agcgccagcc caatggcacc tgcgagccca acccgcgcct caacttctac    22920

ccggtcttcg cggtgcccga ggccctggcc acctaccaca tctttttcaa gaaccaaaag    22980

atccccgtct cctgccgcgc caaccgcacc cgcgccgacg cccttttcaa cctgggtccc    23040

ggcgcccgcc tacctgatat cgcctccttg gaagaggttc ccaagatctt cgagggtctg    23100

ggcagcgacg agactcgggc cgcgaacgct ctgcaaggag aaggaggaga gcatgagcac    23160

cacagcgccc tggtcgagtt ggaaggcgac aacgcgcggc tggcggtgct caaacgcacg    23220

gtcgagctga cccatttcgc ctacccggct ctgaacctgc cccccaaagt catgagcgcg    23280

gtcatggacc aggtgctcat caagcgcgcg tcgcccatct ccgaggacga gggcatgcaa    23340

gactccgagg agggcaagcc cgtggtcagc gacgagcagc tggcccggtg gctgggtcct    23400

aatgctagtc cccagagttt ggaagagcgg cgcaaactca tgatggccgt ggtcctggtg    23460

accgtggagc tggagtgcct gcgccgcttc ttcgccgacg cggagaccct gcgcaaggtc    23520

gaggagaacc tgcactacct cttcaggcac gggttcgtgc gccaggcctg caagatctcc    23580

aacgtggagc tgaccaacct ggtctcctac atgggcatct tgcacgagaa ccgcctgggg    23640

cagaacgtgc tgcacaccac cctgcgcggg gaggcccggc gcgactacat ccgcgactgc    23700

gtctacctct acctctgcca cacctggcag acgggcatgg gcgtgtggca gcagtgtctg    23760

gaggagcaga acctgaaaga gctctgcaag ctcctgcaga agaacctcaa gggtctgtgg    23820

accgggttcg acgagcgcac caccgcctcg gacctggccg acctcatttt ccccgagcgc    23880

ctcaggctga cgctgcgcaa cggcctgccc gactttatga gccaaagcat gttgcaaaac    23940

tttcgctctt tcatcctcga acgctccgga atcctgcccg ccacctgctc cgcgctgccc    24000

tcggacttcg tgccgctgac cttccgcgag tgccccccgc cgctgtggag ccactgctac    24060

ctgctgcgcc tggccaacta cctggcctac cactcggacg tgatcgagga cgtcagcggc    24120

gagggcctgc tcgagtgcca ctgccgctgc aacctctgca cgccgcaccg ctccctggcc    24180

tgcaaccccc agctgctgag cgagacccag atcatcggca ccttcgagtt gcaagggccc    24240

agcgaaggcg agggttcagc cgccaagggg ggtctgaaac tcaccccggg gctgtggacc    24300

tcggcctact tgcgcaagtt cgtgcccgag gactaccatc ccttcgagat caggttctac    24360

gaggaccaat cccatccgcc caaggccgag ctgtcggcct gcgtcatcac ccagggggcg    24420

atcctggccc aattgcaagc catccagaaa tcccgccaag aattcttgct gaaaaagggc    24480

cgcggggtct acctcgaccc ccagaccggt gaggagctca accccggctt cccccaggat    24540

gccccgagga aacaagaagc tgaaagtgga gctgccgccc gtggaggatt tggaggaaga    24600

ctgggagaac agcagtcagg cagaggagga ggagatggag gaagactggg acagcactca    24660

ggcagaggag gacagcctgc aagacagtct ggaggaagac gaggaggagg cagaggagga    24720

ggtggaagaa gcagccgccg ccagaccgtc gtcctcggcg ggggagaaag caagcagcac    24780

ggataccatc tccgctccgg gtcggggtcc cgctcgacca cacagtagat gggacgagac    24840

cggacgattc ccgaacccca ccacccagac cggtaagaag gagcggcagg gatacaagtc    24900

ctggcggggg cacaaaaacg ccatcgtctc ctgcttgcag gcctgcgggg gcaacatctc    24960

cttcacccgg cgctacctgc tcttccaccg cggggtgaac tttccccgca acatcttgca    25020

ttactaccgt cacctccaca gcccctacta cttccaagaa gaggcagcag cagcagaaaa    25080

agaccagcag aaaaccagca gctagaaaat ccacagcggc ggcagcaggt ggactgagga    25140

tcgcggcgaa cgagccggcg caaacccggg agctgaggaa ccggatcttt cccaccctct    25200

atgccatctt ccagcagagt cgggggcagg agcaggaact gaaagtcaag aaccgttctc    25260

tgcgctcgct cacccgcagt tgtctgtatc acaagagcga agaccaactt cagcgcactc    25320

tcgaggacgc cgaggctctc ttcaacaagt actgcgcgct cactcttaaa gagtagcccg    25380

cgcccgccca gtcgcagaaa aaggcgggaa ttacgtcacc tgtgcccttc gccctagccg    25440

cctccaccca tcatcatgag caaagagatt cccacgcctt acatgtggag ctaccagccc    25500

cagatgggcc tggccgccgg tgccgcccag gactactcca cccgcatgaa ttggctcagc    25560

gccgggcccg cgatgatctc acgggtgaat gacatccgcg cccaccgaaa ccagatactc    25620

ctagaacagt cagcgctcac cgccacgccc cgcaatcacc tcaatccgcg taattggccc    25680

gccgccctgg tgtaccagga aattccccag cccacgaccg tactacttcc gcgagacgcc    25740

caggccgaag tccagctgac taactcaggt gtccagctgg cgggcggcgc caccctgtgt    25800

cgtcaccgcc ccgctcaggg tataaagcgg ctggtgatcc ggggcagagg cacacagctc    25860

aacgacgagg tggtgagctc ttcgctgggt ctgcgacctg acggagtctt ccaactcgcc    25920

ggatcgggga gatcttcctt cacgcctcgt caggccgtcc tgactttgga gagttcgtcc    25980

tcgcagcccc gctcgggtgg catcggcact ctccagttcg tggaggagtt cactccctcg    26040

gtctacttca accccttctc cggctccccc ggccactacc cggacgagtt catcccgaac    26100

ttcgacgcca tcagcgagtc ggtggacggc tacgattgag tttaaactca cccccttatc    26160

cagtgaaata aagatcatat tgatgatgat tttacagaaa taaaaaataa tcatttgatt    26220

tgaaataaag atacaatcat attgatgatt tgagtttaac aaaaaaataa agaatcactt    26280

acttgaaatc tgataccagg tctctgtcca tgttttctgc caacaccact tcactcccct    26340

cttcccagct ctggtactgc aggccccggc gggctgcaaa cttcctccac acgctgaagg    26400

ggatgtcaaa ttcctcctgt ccctcaatct tcattttatc ttctatcaga tgtccaaaaa    26460

gcgcgtccgg gtggatgatg acttcgaccc cgtctacccc tacgatgcag acaacgcacc    26520

gaccgtgccc ttcatcaacc cccccttcgt ctcttcagat ggattccaag agaagcccct    26580

gggggtgttg tccctgcgac tggccgaccc cgtcaccacc aagaacgggg aaatcaccct    26640

caagctggga gagggggtgg acctcgattc ctcgggaaaa ctcatctcca acacggccac    26700

caaggccgcc gcccctctca gtttttccaa caacaccatt tcccttaaca tggatcaccc    26760

cttttacact aaagatggaa aattatcctt acaagtttct ccaccattaa atatactgag    26820

aacaagcatt ctaaacacac tagctttagg ttttggatca ggtttaggac tccgtggctc    26880

tgccttggca gtacagttag tctctccact tacatttgat actgatggaa acataaagct    26940

taccttagac agaggtttgc atgttacaac aggagatgca attgaaagca acataagctg    27000

ggctaaaggt ttaaaatttg aagatggagc catagcaacc aacattggaa atgggttaga    27060

gtttggaagc agtagtacag aaacaggtgt tgatgatgct tacccaatcc aagttaaact    27120

tggatctggc cttagctttg acagtacagg agccataatg gctggtaaca aagaagacga    27180

taaactcact ttgtggacaa cacctgatcc atcaccaaac tgtcaaatac tcgcagaaaa    27240

tgatgcaaaa ctaacacttt gcttgactaa atgtggtagt caaatactgg ccactgtgtc    27300

agtcttagtt gtaggaagtg gaaacctaaa ccccattact ggcaccgtaa gcagtgctca    27360

ggtgtttcta cgttttgatg caaacggtgt tcttttaaca gaacattcta cactaaaaaa    27420

atactggggg tataggcagg gagatagcat agatggcact ccatatacca atgctgtagg    27480

attcatgccc aatttaaaag cttatccaaa gtcacaaagt tctactacta aaaataatat    27540

agtagggcaa gtatacatga atggagatgt ttcaaaacct atgcttctca ctataaccct    27600

caatggtact gatgacagca acagtacata ttcaatgtca ttttcataca cctggactaa    27660

tggaagctat gttggagcaa catttggggc taactcttat accttctcat acatcgccca    27720

agaatgaaca ctgtatccca ccctgcatgc caacccttcc caccccactc tgtggaacaa    27780

actctgaaac acaaaataaa ataaagttca agtgttttat tgattcaaca gtttcacaga    27840

accctagtat tcaacctgcc acctccctcc caacacacag agtacacagt cctttctccc    27900

cggctggcct taaaaagcat catatcatgg gtaacagaca tattcttagg tgttatattc    27960

cacacggttt cctgtcgagc caaacgctca tcagtgatat taataaactc cccgggcagc    28020

tcacttaagt tcatgtcgct gtccagctgc tgagccacag gctgctgtcc aacttgcggt    28080

tgcttaacgg gcggcgaagg agaagtccac gcctacatgg gggtagagtc ataatcgtgc    28140

atcaggatag ggcggtggtg ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc    28200

gtcctgcagg aatacaacat ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc    28260

ataaggcgcc ttgtcctccg ggcacagcag cgcaccctga tctcacttaa atcagcacag    28320

taactgcagc acagcaccac aatattgttc aaaatcccac agtgcaaggc gctgtatcca    28380

aagctcatgg cggggaccac agaacccacg tggccatcat accacaagcg caggtagatt    28440

aagtggcgac ccctcataaa cacgctggac ataaacatta cctcttttgg catgttgtaa    28500

ttcaccacct cccggtacca tataaacctc tgattaaaca tggcgccatc caccaccatc    28560

ctaaaccagc tggccaaaac ctgcccgccg gctatacact gcagggaacc gggactggaa    28620

caatgacagt ggagagccca ggactcgtaa ccatggatca tcatgctcgt catgatatca    28680

atgttggcac aacacaggca cacgtgcata cacttcctca ggattacaag ctcctcccgc    28740

gttagaacca tatcccaggg aacaacccat tcctgaatca gcgtaaatcc cacactgcag    28800

ggaagacctc gcacgtaact cacgttgtgc attgtcaaag tgttacattc gggcagcagc    28860

ggatgatcct ccagtatggt agcgcgggtt tctgtctcaa aaggaggtag acgatcccta    28920

ctgtacggag tgcgccgaga caaccgagat cgtgttggtc gtagtgtcat gccaaatgga    28980

acgccggacg tagtcatatt tcctgaagca aaaccaggtg cgggcgtgac aaacagatct    29040

gcgtctccgg tctcgccgct tagatcgctc tgtgtagtag ttgtagtata tccactctct    29100

caaagcatcc aggcgccccc tggcttcggg ttctatgtaa actccttcat gcgccgctgc    29160

cctgataaca tccaccaccg cagaataagc cacacccagc caacctacac attcgttctg    29220

cgagtcacac acgggaggag cgggaagagc tggaagaacc atgattaact ttattccaaa    29280

cggtctcgga gcacttcaaa atgcaggtcc cggaggtggc acctctcgcc cccactgtgt    29340

tggtggaaaa taacagccag gtcaaaggtg acacggttct cgagatgttc cacggtggct    29400

tccagcaaag cctccacgcg cacatccaga aacaagagga cagcgaaagc gggagcgttt    29460

tctaattcct caatcatcat attacactcc tgcaccatcc ccagataatt ttcatttttc    29520

cagccttgaa tgattcgtat tagttcctga ggtaaatcca agccagccat gataaaaagc    29580

tcgcgcagag cgccctccac cggcattctt aagcacaccc tcataattcc aagagattct    29640

gctcctggtt cacctgcagc agattaacaa tgggaatatc aaaatctctg ccgcgatccc    29700

taagctcctc cctcaacaat aactgtatgt aatctttcat atcatctccg aaatttttag    29760

ccatagggcc gccaggaata agagcagggc aagccacatt acagataaag cgaagtcctc    29820

cccagtgwgc attgccaaat gtaagattga aataagcatg ctggctagac cctgtgatat    29880

cttccagata actggacaga aaatcaggca agcaattttt aagaaaatca acaaaagaaa    29940

agtcgtccag gtgcaggttt agagcctcag gaacaacgat ggaataagtg caaggagtgc    30000

gttccagcat ggttagtgtt tttttggtga tctgtagaac aaaaaataaa catgcaatat    30060

taaaccatgc tagcctggcg aacaggtggg taaatcactc tttccagcac caggcaggct    30120

acggggtctc cggcgcgacc ctcgtagaag ctgtcgccat gattgaaaag catcaccgag    30180

agaccttccc ggtggccggc atggatgatt cgagaagaag catacactcc gggaacattg    30240

gcatccgtga gtgaaaaaaa gcgacctata aagcctcggg gcactacaat gctcaatctc    30300

aattccagca aagccacccc atgcggatgg agcacaaaat tggcaggtgc gtaaaaaatg    30360

taattactcc cctcctgcac aggcagcaaa gcccccgctc cctccagaaa cacatacaaa    30420

gcctcagcgt ccatagctta ccgagcacgg caggcgcaag agtcagagaa aaggctgagc    30480

tctaacctga ctgcccgctc ctgtgctcaa tatatagccc taacctacac tgacgtaaag    30540

gccaaagtct aaaaataccc gccaaataat cacacacgcc cagcacacgc ccagaaaccg    30600

gtgacacact caaaaaaata cgcgcacttc ctcaaacgcc caaaactgcc gtcatttccg    30660

ggttcccacg ctacgtcatc aaaacacgac tttcaaattc cgtcgaccgt taaaaacgtc    30720

acccgccccg cccctaacgg tcgcccgtct ctcagccaat cagcgccccg catccccaaa    30780

ttcaaacacc tcatttgcat attaacgcgc acaaaaagtt tgaggtatat tattgatgat    30840

gg                                                                   30842


<210>  3
<211>  4062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding MERS spike protein

<400>  3
atgatccact ccgtgtttct gctgatgttc ctgctgaccc ccaccgagag ctacgtggac       60

gtgggccccg atagcgtgaa gtccgcctgt atcgaagtgg acatccagca gacctttttc      120

gacaagacct ggcccagacc catcgacgtg tccaaggccg acggcatcat ctatccacaa      180

ggccggacct acagcaacat caccattacc taccagggcc tgttcccata tcaaggcgac      240

cacggcgata tgtacgtgta ctctgccggc cacgccaccg gcaccacacc ccagaaactg      300

ttcgtggcca actacagcca ggacgtgaag cagttcgcca acggcttcgt cgtgcggatt      360

ggcgccgctg ccaatagcac cggcacagtg atcatcagcc ccagcaccag cgccaccatc      420

cggaagatct accccgcctt catgctgggc agcagcgtgg gcaatttcag cgacggcaag      480

atgggccggt tcttcaacca caccctggtg ctgctgcctg acggctgtgg cacactgctg      540

agagccttct actgcatcct ggaacccaga agcggcaacc actgccctgc cggcaatagc      600

cacaccagct tcgccaccta ccacacaccc gccaccgatt gctccgacgg caactacaac      660

cggaacgcca gcctgaacag cttcaaagag tacttcaacc tgcggaactg caccttcatg      720

tacacctaca atatcaccga ggacgagatc ctggaatggt tcggcatcac ccagaccgcc      780

cagggcgtgc acctgttcag cagcagatac gtggacctgt acggcggcaa catgttccag      840

tttgccaccc tgcccgtgta cgacaccatc aagtactaca gcatcatccc ccacagcatc      900

cggtccatcc agagcgacag aaaagcctgg gccgccttct acgtgtacaa gctgcagccc      960

ctgaccttcc tgctggactt cagcgtggac ggctacatca gacgggccat cgactgcggc     1020

ttcaacgacc tgagccagct gcactgctcc tacgagagct tcgacgtgga aagcggcgtg     1080

tacagcgtgt ccagcttcga ggccaagcct agcggcagcg tggtggaaca ggctgagggc     1140

gtggaatgcg acttcagccc tctgctgagc ggcacccctc cccaggtgta caacttcaag     1200

cggctggtgt tcaccaactg caattacaac ctgaccaagc tgctgagcct gttctccgtg     1260

aacgacttca cctgtagcca gatcagccct gccgccattg ccagcaactg ctacagcagc     1320

ctgatcctgg actacttcag ctaccccctg agcatgaagt ccgatctgag cgtgtcctcc     1380

gccggaccca tcagccagtt caactacaag cagagcttca gcaaccctac ctgcctgatt     1440

ctggccaccg tgccccacaa tctgaccacc atcaccaagc ccctgaagta cagctacatc     1500

aacaagtgca gcagactgct gtccgacgac cggaccgaag tgccccagct cgtgaacgcc     1560

aaccagtaca gcccctgcgt gtccatcgtg cccagcaccg tgtgggagga cggcgactac     1620

tacagaaagc agctgagccc cctggaaggc ggcggatggc tggtggcttc tggaagcaca     1680

gtggccatga ccgagcagct gcagatgggc tttggcatca ccgtgcagta cggcaccgac     1740

accaacagcg tgtgccccaa gctggaattc gccaatgaca ccaagatcgc cagtcagctg     1800

ggcaactgcg tggaatactc cctgtatggc gtgtccggac ggggcgtgtt ccagaattgc     1860

acagcagtgg gagtgcggca gcagagattc gtgtacgatg cctaccagaa cctcgtgggc     1920

tactacagcg acgacggcaa ttactactgc ctgcgggcct gtgtgtccgt gcccgtgtcc     1980

gtgatctacg acaaagagac aaagacccac gccacactgt tcggctccgt ggcctgcgag     2040

cacatcagct ccaccatgag ccagtactcc cgctccaccc ggtccatgct gaagcggaga     2100

gatagcacct acggccccct gcagacacct gtgggatgtg tgctgggcct cgtgaacagc     2160

tccctgtttg tggaagattg caagctgccc ctgggccaga gcctgtgtgc cctgccagat     2220

acccctagca ccctgacccc tagaagcgtg cgctctgtgc ccggcgaaat gcggctggcc     2280

tctatcgcct tcaatcaccc catccaggtg gaccagctga actccagcta cttcaagctg     2340

agcatcccca ccaacttcag cttcggcgtg acccaggagt acatccagac cacaatccag     2400

aaagtgaccg tggactgcaa gcagtacgtg tgcaacggct ttcagaagtg cgaacagctg     2460

ctgcgcgagt acggccagtt ctgcagcaag atcaaccagg ccctgcacgg ggccaacctg     2520

agacaggatg acagcgtgcg gaacctgttc gccagcgtga aaagcagcca gtccagcccc     2580

atcatccctg gcttcggcgg cgactttaac ctgaccctgc tggaacctgt gtccatcagc     2640

accggctcca gaagcgccag atccgccatc gaggacctgc tgttcgacaa agtgaccatt     2700

gccgaccccg gctacatgca gggctacgac gattgcatgc agcagggccc agccagcgcc     2760

agggatctga tctgtgccca gtatgtggcc ggctacaagg tgctgccccc cctgatggac     2820

gtgaacatgg aagccgccta cacctccagc ctgctgggat ctattgctgg cgtgggctgg     2880

acagccggcc tgtctagctt tgccgccatc cctttcgccc agagcatctt ctaccggctg     2940

aacggcgtgg gaatcaccca gcaggtgctg agcgagaacc agaagctgat cgccaacaag     3000

tttaaccagg cactgggcgc catgcagacc ggcttcacca ccaccaacga ggccttcaga     3060

aaggtgcagg acgccgtgaa caacaacgcc caggctctga gcaagctggc ctccgagctg     3120

agcaatacct tcggcgccat cagcgcctcc atcggcgaca tcatccagcg gctggacgtg     3180

ctggaacagg acgcccagat cgaccggctg atcaacggca gactgaccac cctgaacgcc     3240

ttcgtggcac agcagctcgt gcggagcgaa tctgccgctc tgtctgctca gctggccaag     3300

gacaaagtga acgagtgcgt gaaggcccag tccaagcgga gcggcttttg tggccagggc     3360

acccacatcg tgtccttcgt cgtgaatgcc cccaacggcc tgtactttat gcacgtgggc     3420

tattacccca gcaaccacat cgaggtggtg tccgcctatg gcctgtgcga cgccgccaat     3480

cctaccaact gtatcgcccc cgtgaacggc tacttcatca agaccaacaa cacccggatc     3540

gtggacgagt ggtcctacac cggcagcagc ttctacgccc ccgagcctat cacctccctg     3600

aacaccaaat acgtggcccc ccaagtgaca taccagaaca tctccaccaa cctgccccca     3660

cccctgctgg gcaatagcac agggatcgac ttccaggacg agctggacga gttcttcaag     3720

aacgtgtcca cctccatccc caacttcggc agcctgaccc agatcaacac cactctgctg     3780

gacctgacct acgagatgct gtccctgcag caggtcgtga aagccctgaa cgagtcctac     3840

atcgacctga aagagctggg gaactacacc tactacaaca agtggccttg gtacatttgg     3900

ctgggcttta tcgccggcct ggtggccctg gccctgtgcg tgttcttcat cctgtgctgt     3960

accggctgcg gcaccaattg catgggcaag ctgaaatgca accggtgctg cgacagatac     4020

gaggaatacg acctggaacc tcacaaagtg catgtgcact ga                        4062


<210>  4
<211>  4155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding MERS spike protein with tPA leader

<400>  4
atggacgcca tgaagagggg cctgtgctgc gtgctgctgc tgtgtggcgc cgtgtttgtg       60

tccgccagcc aggaaatcca cgcccggttc agacggatcc actccgtgtt tctgctgatg      120

ttcctgctga cccccaccga gagctacgtg gacgtgggcc ccgatagcgt gaagtccgcc      180

tgtatcgaag tggacatcca gcagaccttt ttcgacaaga cctggcccag acccatcgac      240

gtgtccaagg ccgacggcat catctatcca caaggccgga cctacagcaa catcaccatt      300

acctaccagg gcctgttccc atatcaaggc gaccacggcg atatgtacgt gtactctgcc      360

ggccacgcca ccggcaccac accccagaaa ctgttcgtgg ccaactacag ccaggacgtg      420

aagcagttcg ccaacggctt cgtcgtgcgg attggcgccg ctgccaatag caccggcaca      480

gtgatcatca gccccagcac cagcgccacc atccggaaga tctaccccgc cttcatgctg      540

ggcagcagcg tgggcaattt cagcgacggc aagatgggcc ggttcttcaa ccacaccctg      600

gtgctgctgc ctgacggctg tggcacactg ctgagagcct tctactgcat cctggaaccc      660

agaagcggca accactgccc tgccggcaat agccacacca gcttcgccac ctaccacaca      720

cccgccaccg attgctccga cggcaactac aaccggaacg ccagcctgaa cagcttcaaa      780

gagtacttca acctgcggaa ctgcaccttc atgtacacct acaatatcac cgaggacgag      840

atcctggaat ggttcggcat cacccagacc gcccagggcg tgcacctgtt cagcagcaga      900

tacgtggacc tgtacggcgg caacatgttc cagtttgcca ccctgcccgt gtacgacacc      960

atcaagtact acagcatcat cccccacagc atccggtcca tccagagcga cagaaaagcc     1020

tgggccgcct tctacgtgta caagctgcag cccctgacct tcctgctgga cttcagcgtg     1080

gacggctaca tcagacgggc catcgactgc ggcttcaacg acctgagcca gctgcactgc     1140

tcctacgaga gcttcgacgt ggaaagcggc gtgtacagcg tgtccagctt cgaggccaag     1200

cctagcggca gcgtggtgga acaggctgag ggcgtggaat gcgacttcag ccctctgctg     1260

agcggcaccc ctccccaggt gtacaacttc aagcggctgg tgttcaccaa ctgcaattac     1320

aacctgacca agctgctgag cctgttctcc gtgaacgact tcacctgtag ccagatcagc     1380

cctgccgcca ttgccagcaa ctgctacagc agcctgatcc tggactactt cagctacccc     1440

ctgagcatga agtccgatct gagcgtgtcc tccgccggac ccatcagcca gttcaactac     1500

aagcagagct tcagcaaccc tacctgcctg attctggcca ccgtgcccca caatctgacc     1560

accatcacca agcccctgaa gtacagctac atcaacaagt gcagcagact gctgtccgac     1620

gaccggaccg aagtgcccca gctcgtgaac gccaaccagt acagcccctg cgtgtccatc     1680

gtgcccagca ccgtgtggga ggacggcgac tactacagaa agcagctgag ccccctggaa     1740

ggcggcggat ggctggtggc ttctggaagc acagtggcca tgaccgagca gctgcagatg     1800

ggctttggca tcaccgtgca gtacggcacc gacaccaaca gcgtgtgccc caagctggaa     1860

ttcgccaatg acaccaagat cgccagtcag ctgggcaact gcgtggaata ctccctgtat     1920

ggcgtgtccg gacggggcgt gttccagaat tgcacagcag tgggagtgcg gcagcagaga     1980

ttcgtgtacg atgcctacca gaacctcgtg ggctactaca gcgacgacgg caattactac     2040

tgcctgcggg cctgtgtgtc cgtgcccgtg tccgtgatct acgacaaaga gacaaagacc     2100

cacgccacac tgttcggctc cgtggcctgc gagcacatca gctccaccat gagccagtac     2160

tcccgctcca cccggtccat gctgaagcgg agagatagca cctacggccc cctgcagaca     2220

cctgtgggat gtgtgctggg cctcgtgaac agctccctgt ttgtggaaga ttgcaagctg     2280

cccctgggcc agagcctgtg tgccctgcca gataccccta gcaccctgac ccctagaagc     2340

gtgcgctctg tgcccggcga aatgcggctg gcctctatcg ccttcaatca ccccatccag     2400

gtggaccagc tgaactccag ctacttcaag ctgagcatcc ccaccaactt cagcttcggc     2460

gtgacccagg agtacatcca gaccacaatc cagaaagtga ccgtggactg caagcagtac     2520

gtgtgcaacg gctttcagaa gtgcgaacag ctgctgcgcg agtacggcca gttctgcagc     2580

aagatcaacc aggccctgca cggggccaac ctgagacagg atgacagcgt gcggaacctg     2640

ttcgccagcg tgaaaagcag ccagtccagc cccatcatcc ctggcttcgg cggcgacttt     2700

aacctgaccc tgctggaacc tgtgtccatc agcaccggct ccagaagcgc cagatccgcc     2760

atcgaggacc tgctgttcga caaagtgacc attgccgacc ccggctacat gcagggctac     2820

gacgattgca tgcagcaggg cccagccagc gccagggatc tgatctgtgc ccagtatgtg     2880

gccggctaca aggtgctgcc ccccctgatg gacgtgaaca tggaagccgc ctacacctcc     2940

agcctgctgg gatctattgc tggcgtgggc tggacagccg gcctgtctag ctttgccgcc     3000

atccctttcg cccagagcat cttctaccgg ctgaacggcg tgggaatcac ccagcaggtg     3060

ctgagcgaga accagaagct gatcgccaac aagtttaacc aggcactggg cgccatgcag     3120

accggcttca ccaccaccaa cgaggccttc agaaaggtgc aggacgccgt gaacaacaac     3180

gcccaggctc tgagcaagct ggcctccgag ctgagcaata ccttcggcgc catcagcgcc     3240

tccatcggcg acatcatcca gcggctggac gtgctggaac aggacgccca gatcgaccgg     3300

ctgatcaacg gcagactgac caccctgaac gccttcgtgg cacagcagct cgtgcggagc     3360

gaatctgccg ctctgtctgc tcagctggcc aaggacaaag tgaacgagtg cgtgaaggcc     3420

cagtccaagc ggagcggctt ttgtggccag ggcacccaca tcgtgtcctt cgtcgtgaat     3480

gcccccaacg gcctgtactt tatgcacgtg ggctattacc ccagcaacca catcgaggtg     3540

gtgtccgcct atggcctgtg cgacgccgcc aatcctacca actgtatcgc ccccgtgaac     3600

ggctacttca tcaagaccaa caacacccgg atcgtggacg agtggtccta caccggcagc     3660

agcttctacg cccccgagcc tatcacctcc ctgaacacca aatacgtggc cccccaagtg     3720

acataccaga acatctccac caacctgccc ccacccctgc tgggcaatag cacagggatc     3780

gacttccagg acgagctgga cgagttcttc aagaacgtgt ccacctccat ccccaacttc     3840

ggcagcctga cccagatcaa caccactctg ctggacctga cctacgagat gctgtccctg     3900

cagcaggtcg tgaaagccct gaacgagtcc tacatcgacc tgaaagagct ggggaactac     3960

acctactaca acaagtggcc ttggtacatt tggctgggct ttatcgccgg cctggtggcc     4020

ctggccctgt gcgtgttctt catcctgtgc tgtaccggct gcggcaccaa ttgcatgggc     4080

aagctgaaat gcaaccggtg ctgcgacaga tacgaggaat acgacctgga acctcacaaa     4140

gtgcatgtgc actga                                                      4155


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA leader with A

<400>  5

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA leader with P

<400>  6

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA with A without C-terminal 'RR'

<400>  7

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA with P without C-terminal 'RR'

<400>  8

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe 
            20                  25                  30  


<210>  9
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding tPA, which has been codon optimised 
       for human codon usage, (this is the sequence encoding SEQ ID NO: 
       5):

<400>  9
atggacgcca tgaagagggg cctgtgctgc gtgctgctgc tgtgtggcgc cgtgtttgtg       60

tccgccagcc aggaaatcca cgcccggttc agacgg                                 96


