﻿               SEQUENCE LISTING

<110> CeMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH

<120> UV sensitivity and genomic instability due to defective nucleotide excision repair is alleviated b MUTYH loss

<130> AA1326 PCT S3

<150> EP 17 17 2748.0
<151> 2017-05-24

<160> 10

<170> BiSSAP 1.3

<210> 1
<211> 546
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1-Isoform Alpha-1

<400> 1
Met Thr Pro Leu Val Ser Arg Leu Ser Arg Leu Trp Ala Ile Met Arg 
1               5                   10                  15      
Lys Pro Arg Ala Ala Val Gly Ser Gly His Arg Lys Gln Ala Ala Ser 
            20                  25                  30          
Gln Glu Gly Arg Gln Lys His Ala Lys Asn Asn Ser Gln Ala Lys Pro 
        35                  40                  45              
Ser Ala Cys Asp Gly Met Ile Ala Glu Cys Pro Gly Ala Pro Ala Gly 
    50                  55                  60                  
Leu Ala Arg Gln Pro Glu Glu Val Val Leu Gln Ala Ser Val Ser Ser 
65                  70                  75                  80  
Tyr His Leu Phe Arg Asp Val Ala Glu Val Thr Ala Phe Arg Gly Ser 
                85                  90                  95      
Leu Leu Ser Trp Tyr Asp Gln Glu Lys Arg Asp Leu Pro Trp Arg Arg 
            100                 105                 110         
Arg Ala Glu Asp Glu Met Asp Leu Asp Arg Arg Ala Tyr Ala Val Trp 
        115                 120                 125             
Val Ser Glu Val Met Leu Gln Gln Thr Gln Val Ala Thr Val Ile Asn 
    130                 135                 140                 
Tyr Tyr Thr Gly Trp Met Gln Lys Trp Pro Thr Leu Gln Asp Leu Ala 
145                 150                 155                 160 
Ser Ala Ser Leu Glu Glu Val Asn Gln Leu Trp Ala Gly Leu Gly Tyr 
                165                 170                 175     
Tyr Ser Arg Gly Arg Arg Leu Gln Glu Gly Ala Arg Lys Val Val Glu 
            180                 185                 190         
Glu Leu Gly Gly His Met Pro Arg Thr Ala Glu Thr Leu Gln Gln Leu 
        195                 200                 205             
Leu Pro Gly Val Gly Arg Tyr Thr Ala Gly Ala Ile Ala Ser Ile Ala 
    210                 215                 220                 
Phe Gly Gln Ala Thr Gly Val Val Asp Gly Asn Val Ala Arg Val Leu 
225                 230                 235                 240 
Cys Arg Val Arg Ala Ile Gly Ala Asp Pro Ser Ser Thr Leu Val Ser 
                245                 250                 255     
Gln Gln Leu Trp Gly Leu Ala Gln Gln Leu Val Asp Pro Ala Arg Pro 
            260                 265                 270         
Gly Asp Phe Asn Gln Ala Ala Met Glu Leu Gly Ala Thr Val Cys Thr 
        275                 280                 285             
Pro Gln Arg Pro Leu Cys Ser Gln Cys Pro Val Glu Ser Leu Cys Arg 
    290                 295                 300                 
Ala Arg Gln Arg Val Glu Gln Glu Gln Leu Leu Ala Ser Gly Ser Leu 
305                 310                 315                 320 
Ser Gly Ser Pro Asp Val Glu Glu Cys Ala Pro Asn Thr Gly Gln Cys 
                325                 330                 335     
His Leu Cys Leu Pro Pro Ser Glu Pro Trp Asp Gln Thr Leu Gly Val 
            340                 345                 350         
Val Asn Phe Pro Arg Lys Ala Ser Arg Lys Pro Pro Arg Glu Glu Ser 
        355                 360                 365             
Ser Ala Thr Cys Val Leu Glu Gln Pro Gly Ala Leu Gly Ala Gln Ile 
    370                 375                 380                 
Leu Leu Val Gln Arg Pro Asn Ser Gly Leu Leu Ala Gly Leu Trp Glu 
385                 390                 395                 400 
Phe Pro Ser Val Thr Trp Glu Pro Ser Glu Gln Leu Gln Arg Lys Ala 
                405                 410                 415     
Leu Leu Gln Glu Leu Gln Arg Trp Ala Gly Pro Leu Pro Ala Thr His 
            420                 425                 430         
Leu Arg His Leu Gly Glu Val Val His Thr Phe Ser His Ile Lys Leu 
        435                 440                 445             
Thr Tyr Gln Val Tyr Gly Leu Ala Leu Glu Gly Gln Thr Pro Val Thr 
    450                 455                 460                 
Thr Val Pro Pro Gly Ala Arg Trp Leu Thr Gln Glu Glu Phe His Thr 
465                 470                 475                 480 
Ala Ala Val Ser Thr Ala Met Lys Lys Val Phe Arg Val Tyr Gln Gly 
                485                 490                 495     
Gln Gln Pro Gly Thr Cys Met Gly Ser Lys Arg Ser Gln Val Ser Ser 
            500                 505                 510         
Pro Cys Ser Arg Lys Lys Pro Arg Met Gly Gln Gln Val Leu Asp Asn 
        515                 520                 525             
Phe Phe Arg Ser His Ile Ser Thr Asp Ala His Ser Leu Asn Ser Ala 
    530                 535                 540                 
Ala Gln 
545     

<210> 2
<211> 536
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1-Isoform Alpha-2

<400> 2
Met Thr Pro Leu Val Ser Arg Leu Ser Arg Leu Trp Ala Ile Met Arg 
1               5                   10                  15      
Lys Pro Arg Ala Ala Val Gly Ser Gly His Arg Lys Gln Ala Ala Ser 
            20                  25                  30          
Gln Glu Gly Arg Gln Lys His Ala Lys Asn Asn Ser Gln Ala Lys Pro 
        35                  40                  45              
Ser Ala Cys Asp Ala Gly Leu Ala Arg Gln Pro Glu Glu Val Val Leu 
    50                  55                  60                  
Gln Ala Ser Val Ser Ser Tyr His Leu Phe Arg Asp Val Ala Glu Val 
65                  70                  75                  80  
Thr Ala Phe Arg Gly Ser Leu Leu Ser Trp Tyr Asp Gln Glu Lys Arg 
                85                  90                  95      
Asp Leu Pro Trp Arg Arg Arg Ala Glu Asp Glu Met Asp Leu Asp Arg 
            100                 105                 110         
Arg Ala Tyr Ala Val Trp Val Ser Glu Val Met Leu Gln Gln Thr Gln 
        115                 120                 125             
Val Ala Thr Val Ile Asn Tyr Tyr Thr Gly Trp Met Gln Lys Trp Pro 
    130                 135                 140                 
Thr Leu Gln Asp Leu Ala Ser Ala Ser Leu Glu Glu Val Asn Gln Leu 
145                 150                 155                 160 
Trp Ala Gly Leu Gly Tyr Tyr Ser Arg Gly Arg Arg Leu Gln Glu Gly 
                165                 170                 175     
Ala Arg Lys Val Val Glu Glu Leu Gly Gly His Met Pro Arg Thr Ala 
            180                 185                 190         
Glu Thr Leu Gln Gln Leu Leu Pro Gly Val Gly Arg Tyr Thr Ala Gly 
        195                 200                 205             
Ala Ile Ala Ser Ile Ala Phe Gly Gln Ala Thr Gly Val Val Asp Gly 
    210                 215                 220                 
Asn Val Ala Arg Val Leu Cys Arg Val Arg Ala Ile Gly Ala Asp Pro 
225                 230                 235                 240 
Ser Ser Thr Leu Val Ser Gln Gln Leu Trp Gly Leu Ala Gln Gln Leu 
                245                 250                 255     
Val Asp Pro Ala Arg Pro Gly Asp Phe Asn Gln Ala Ala Met Glu Leu 
            260                 265                 270         
Gly Ala Thr Val Cys Thr Pro Gln Arg Pro Leu Cys Ser Gln Cys Pro 
        275                 280                 285             
Val Glu Ser Leu Cys Arg Ala Arg Gln Arg Val Glu Gln Glu Gln Leu 
    290                 295                 300                 
Leu Ala Ser Gly Ser Leu Ser Gly Ser Pro Asp Val Glu Glu Cys Ala 
305                 310                 315                 320 
Pro Asn Thr Gly Gln Cys His Leu Cys Leu Pro Pro Ser Glu Pro Trp 
                325                 330                 335     
Asp Gln Thr Leu Gly Val Val Asn Phe Pro Arg Lys Ala Ser Arg Lys 
            340                 345                 350         
Pro Pro Arg Glu Glu Ser Ser Ala Thr Cys Val Leu Glu Gln Pro Gly 
        355                 360                 365             
Ala Leu Gly Ala Gln Ile Leu Leu Val Gln Arg Pro Asn Ser Gly Leu 
    370                 375                 380                 
Leu Ala Gly Leu Trp Glu Phe Pro Ser Val Thr Trp Glu Pro Ser Glu 
385                 390                 395                 400 
Gln Leu Gln Arg Lys Ala Leu Leu Gln Glu Leu Gln Arg Trp Ala Gly 
                405                 410                 415     
Pro Leu Pro Ala Thr His Leu Arg His Leu Gly Glu Val Val His Thr 
            420                 425                 430         
Phe Ser His Ile Lys Leu Thr Tyr Gln Val Tyr Gly Leu Ala Leu Glu 
        435                 440                 445             
Gly Gln Thr Pro Val Thr Thr Val Pro Pro Gly Ala Arg Trp Leu Thr 
    450                 455                 460                 
Gln Glu Glu Phe His Thr Ala Ala Val Ser Thr Ala Met Lys Lys Val 
465                 470                 475                 480 
Phe Arg Val Tyr Gln Gly Gln Gln Pro Gly Thr Cys Met Gly Ser Lys 
                485                 490                 495     
Arg Ser Gln Val Ser Ser Pro Cys Ser Arg Lys Lys Pro Arg Met Gly 
            500                 505                 510         
Gln Gln Val Leu Asp Asn Phe Phe Arg Ser His Ile Ser Thr Asp Ala 
        515                 520                 525             
His Ser Leu Asn Ser Ala Ala Gln 
    530                 535     

<210> 3
<211> 535
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1-Isoform Alpha-3

<400> 3
Met Thr Pro Leu Val Ser Arg Leu Ser Arg Leu Trp Ala Ile Met Arg 
1               5                   10                  15      
Lys Pro Arg Ala Ala Val Gly Ser Gly His Arg Lys Gln Ala Ala Ser 
            20                  25                  30          
Gln Glu Gly Arg Gln Lys His Ala Lys Asn Asn Ser Gln Ala Lys Pro 
        35                  40                  45              
Ser Ala Cys Asp Gly Leu Ala Arg Gln Pro Glu Glu Val Val Leu Gln 
    50                  55                  60                  
Ala Ser Val Ser Ser Tyr His Leu Phe Arg Asp Val Ala Glu Val Thr 
65                  70                  75                  80  
Ala Phe Arg Gly Ser Leu Leu Ser Trp Tyr Asp Gln Glu Lys Arg Asp 
                85                  90                  95      
Leu Pro Trp Arg Arg Arg Ala Glu Asp Glu Met Asp Leu Asp Arg Arg 
            100                 105                 110         
Ala Tyr Ala Val Trp Val Ser Glu Val Met Leu Gln Gln Thr Gln Val 
        115                 120                 125             
Ala Thr Val Ile Asn Tyr Tyr Thr Gly Trp Met Gln Lys Trp Pro Thr 
    130                 135                 140                 
Leu Gln Asp Leu Ala Ser Ala Ser Leu Glu Glu Val Asn Gln Leu Trp 
145                 150                 155                 160 
Ala Gly Leu Gly Tyr Tyr Ser Arg Gly Arg Arg Leu Gln Glu Gly Ala 
                165                 170                 175     
Arg Lys Val Val Glu Glu Leu Gly Gly His Met Pro Arg Thr Ala Glu 
            180                 185                 190         
Thr Leu Gln Gln Leu Leu Pro Gly Val Gly Arg Tyr Thr Ala Gly Ala 
        195                 200                 205             
Ile Ala Ser Ile Ala Phe Gly Gln Ala Thr Gly Val Val Asp Gly Asn 
    210                 215                 220                 
Val Ala Arg Val Leu Cys Arg Val Arg Ala Ile Gly Ala Asp Pro Ser 
225                 230                 235                 240 
Ser Thr Leu Val Ser Gln Gln Leu Trp Gly Leu Ala Gln Gln Leu Val 
                245                 250                 255     
Asp Pro Ala Arg Pro Gly Asp Phe Asn Gln Ala Ala Met Glu Leu Gly 
            260                 265                 270         
Ala Thr Val Cys Thr Pro Gln Arg Pro Leu Cys Ser Gln Cys Pro Val 
        275                 280                 285             
Glu Ser Leu Cys Arg Ala Arg Gln Arg Val Glu Gln Glu Gln Leu Leu 
    290                 295                 300                 
Ala Ser Gly Ser Leu Ser Gly Ser Pro Asp Val Glu Glu Cys Ala Pro 
305                 310                 315                 320 
Asn Thr Gly Gln Cys His Leu Cys Leu Pro Pro Ser Glu Pro Trp Asp 
                325                 330                 335     
Gln Thr Leu Gly Val Val Asn Phe Pro Arg Lys Ala Ser Arg Lys Pro 
            340                 345                 350         
Pro Arg Glu Glu Ser Ser Ala Thr Cys Val Leu Glu Gln Pro Gly Ala 
        355                 360                 365             
Leu Gly Ala Gln Ile Leu Leu Val Gln Arg Pro Asn Ser Gly Leu Leu 
    370                 375                 380                 
Ala Gly Leu Trp Glu Phe Pro Ser Val Thr Trp Glu Pro Ser Glu Gln 
385                 390                 395                 400 
Leu Gln Arg Lys Ala Leu Leu Gln Glu Leu Gln Arg Trp Ala Gly Pro 
                405                 410                 415     
Leu Pro Ala Thr His Leu Arg His Leu Gly Glu Val Val His Thr Phe 
            420                 425                 430         
Ser His Ile Lys Leu Thr Tyr Gln Val Tyr Gly Leu Ala Leu Glu Gly 
        435                 440                 445             
Gln Thr Pro Val Thr Thr Val Pro Pro Gly Ala Arg Trp Leu Thr Gln 
    450                 455                 460                 
Glu Glu Phe His Thr Ala Ala Val Ser Thr Ala Met Lys Lys Val Phe 
465                 470                 475                 480 
Arg Val Tyr Gln Gly Gln Gln Pro Gly Thr Cys Met Gly Ser Lys Arg 
                485                 490                 495     
Ser Gln Val Ser Ser Pro Cys Ser Arg Lys Lys Pro Arg Met Gly Gln 
            500                 505                 510         
Gln Val Leu Asp Asn Phe Phe Arg Ser His Ile Ser Thr Asp Ala His 
        515                 520                 525             
Ser Leu Asn Ser Ala Ala Gln 
    530                 535 

<210> 4
<211> 532
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1-Isoform Beta-1

<400> 4
Met Arg Lys Pro Arg Ala Ala Val Gly Ser Gly His Arg Lys Gln Ala 
1               5                   10                  15      
Ala Ser Gln Glu Gly Arg Gln Lys His Ala Lys Asn Asn Ser Gln Ala 
            20                  25                  30          
Lys Pro Ser Ala Cys Asp Gly Met Ile Ala Glu Cys Pro Gly Ala Pro 
        35                  40                  45              
Ala Gly Leu Ala Arg Gln Pro Glu Glu Val Val Leu Gln Ala Ser Val 
    50                  55                  60                  
Ser Ser Tyr His Leu Phe Arg Asp Val Ala Glu Val Thr Ala Phe Arg 
65                  70                  75                  80  
Gly Ser Leu Leu Ser Trp Tyr Asp Gln Glu Lys Arg Asp Leu Pro Trp 
                85                  90                  95      
Arg Arg Arg Ala Glu Asp Glu Met Asp Leu Asp Arg Arg Ala Tyr Ala 
            100                 105                 110         
Val Trp Val Ser Glu Val Met Leu Gln Gln Thr Gln Val Ala Thr Val 
        115                 120                 125             
Ile Asn Tyr Tyr Thr Gly Trp Met Gln Lys Trp Pro Thr Leu Gln Asp 
    130                 135                 140                 
Leu Ala Ser Ala Ser Leu Glu Glu Val Asn Gln Leu Trp Ala Gly Leu 
145                 150                 155                 160 
Gly Tyr Tyr Ser Arg Gly Arg Arg Leu Gln Glu Gly Ala Arg Lys Val 
                165                 170                 175     
Val Glu Glu Leu Gly Gly His Met Pro Arg Thr Ala Glu Thr Leu Gln 
            180                 185                 190         
Gln Leu Leu Pro Gly Val Gly Arg Tyr Thr Ala Gly Ala Ile Ala Ser 
        195                 200                 205             
Ile Ala Phe Gly Gln Ala Thr Gly Val Val Asp Gly Asn Val Ala Arg 
    210                 215                 220                 
Val Leu Cys Arg Val Arg Ala Ile Gly Ala Asp Pro Ser Ser Thr Leu 
225                 230                 235                 240 
Val Ser Gln Gln Leu Trp Gly Leu Ala Gln Gln Leu Val Asp Pro Ala 
                245                 250                 255     
Arg Pro Gly Asp Phe Asn Gln Ala Ala Met Glu Leu Gly Ala Thr Val 
            260                 265                 270         
Cys Thr Pro Gln Arg Pro Leu Cys Ser Gln Cys Pro Val Glu Ser Leu 
        275                 280                 285             
Cys Arg Ala Arg Gln Arg Val Glu Gln Glu Gln Leu Leu Ala Ser Gly 
    290                 295                 300                 
Ser Leu Ser Gly Ser Pro Asp Val Glu Glu Cys Ala Pro Asn Thr Gly 
305                 310                 315                 320 
Gln Cys His Leu Cys Leu Pro Pro Ser Glu Pro Trp Asp Gln Thr Leu 
                325                 330                 335     
Gly Val Val Asn Phe Pro Arg Lys Ala Ser Arg Lys Pro Pro Arg Glu 
            340                 345                 350         
Glu Ser Ser Ala Thr Cys Val Leu Glu Gln Pro Gly Ala Leu Gly Ala 
        355                 360                 365             
Gln Ile Leu Leu Val Gln Arg Pro Asn Ser Gly Leu Leu Ala Gly Leu 
    370                 375                 380                 
Trp Glu Phe Pro Ser Val Thr Trp Glu Pro Ser Glu Gln Leu Gln Arg 
385                 390                 395                 400 
Lys Ala Leu Leu Gln Glu Leu Gln Arg Trp Ala Gly Pro Leu Pro Ala 
                405                 410                 415     
Thr His Leu Arg His Leu Gly Glu Val Val His Thr Phe Ser His Ile 
            420                 425                 430         
Lys Leu Thr Tyr Gln Val Tyr Gly Leu Ala Leu Glu Gly Gln Thr Pro 
        435                 440                 445             
Val Thr Thr Val Pro Pro Gly Ala Arg Trp Leu Thr Gln Glu Glu Phe 
    450                 455                 460                 
His Thr Ala Ala Val Ser Thr Ala Met Lys Lys Val Phe Arg Val Tyr 
465                 470                 475                 480 
Gln Gly Gln Gln Pro Gly Thr Cys Met Gly Ser Lys Arg Ser Gln Val 
                485                 490                 495     
Ser Ser Pro Cys Ser Arg Lys Lys Pro Arg Met Gly Gln Gln Val Leu 
            500                 505                 510         
Asp Asn Phe Phe Arg Ser His Ile Ser Thr Asp Ala His Ser Leu Asn 
        515                 520                 525             
Ser Ala Ala Gln 
    530         

<210> 5
<211> 522
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1-Isoform Gamma-2

<400> 5
Met Arg Lys Pro Arg Ala Ala Val Gly Ser Gly His Arg Lys Gln Ala 
1               5                   10                  15      
Ala Ser Gln Glu Gly Arg Gln Lys His Ala Lys Asn Asn Ser Gln Ala 
            20                  25                  30          
Lys Pro Ser Ala Cys Asp Ala Gly Leu Ala Arg Gln Pro Glu Glu Val 
        35                  40                  45              
Val Leu Gln Ala Ser Val Ser Ser Tyr His Leu Phe Arg Asp Val Ala 
    50                  55                  60                  
Glu Val Thr Ala Phe Arg Gly Ser Leu Leu Ser Trp Tyr Asp Gln Glu 
65                  70                  75                  80  
Lys Arg Asp Leu Pro Trp Arg Arg Arg Ala Glu Asp Glu Met Asp Leu 
                85                  90                  95      
Asp Arg Arg Ala Tyr Ala Val Trp Val Ser Glu Val Met Leu Gln Gln 
            100                 105                 110         
Thr Gln Val Ala Thr Val Ile Asn Tyr Tyr Thr Gly Trp Met Gln Lys 
        115                 120                 125             
Trp Pro Thr Leu Gln Asp Leu Ala Ser Ala Ser Leu Glu Glu Val Asn 
    130                 135                 140                 
Gln Leu Trp Ala Gly Leu Gly Tyr Tyr Ser Arg Gly Arg Arg Leu Gln 
145                 150                 155                 160 
Glu Gly Ala Arg Lys Val Val Glu Glu Leu Gly Gly His Met Pro Arg 
                165                 170                 175     
Thr Ala Glu Thr Leu Gln Gln Leu Leu Pro Gly Val Gly Arg Tyr Thr 
            180                 185                 190         
Ala Gly Ala Ile Ala Ser Ile Ala Phe Gly Gln Ala Thr Gly Val Val 
        195                 200                 205             
Asp Gly Asn Val Ala Arg Val Leu Cys Arg Val Arg Ala Ile Gly Ala 
    210                 215                 220                 
Asp Pro Ser Ser Thr Leu Val Ser Gln Gln Leu Trp Gly Leu Ala Gln 
225                 230                 235                 240 
Gln Leu Val Asp Pro Ala Arg Pro Gly Asp Phe Asn Gln Ala Ala Met 
                245                 250                 255     
Glu Leu Gly Ala Thr Val Cys Thr Pro Gln Arg Pro Leu Cys Ser Gln 
            260                 265                 270         
Cys Pro Val Glu Ser Leu Cys Arg Ala Arg Gln Arg Val Glu Gln Glu 
        275                 280                 285             
Gln Leu Leu Ala Ser Gly Ser Leu Ser Gly Ser Pro Asp Val Glu Glu 
    290                 295                 300                 
Cys Ala Pro Asn Thr Gly Gln Cys His Leu Cys Leu Pro Pro Ser Glu 
305                 310                 315                 320 
Pro Trp Asp Gln Thr Leu Gly Val Val Asn Phe Pro Arg Lys Ala Ser 
                325                 330                 335     
Arg Lys Pro Pro Arg Glu Glu Ser Ser Ala Thr Cys Val Leu Glu Gln 
            340                 345                 350         
Pro Gly Ala Leu Gly Ala Gln Ile Leu Leu Val Gln Arg Pro Asn Ser 
        355                 360                 365             
Gly Leu Leu Ala Gly Leu Trp Glu Phe Pro Ser Val Thr Trp Glu Pro 
    370                 375                 380                 
Ser Glu Gln Leu Gln Arg Lys Ala Leu Leu Gln Glu Leu Gln Arg Trp 
385                 390                 395                 400 
Ala Gly Pro Leu Pro Ala Thr His Leu Arg His Leu Gly Glu Val Val 
                405                 410                 415     
His Thr Phe Ser His Ile Lys Leu Thr Tyr Gln Val Tyr Gly Leu Ala 
            420                 425                 430         
Leu Glu Gly Gln Thr Pro Val Thr Thr Val Pro Pro Gly Ala Arg Trp 
        435                 440                 445             
Leu Thr Gln Glu Glu Phe His Thr Ala Ala Val Ser Thr Ala Met Lys 
    450                 455                 460                 
Lys Val Phe Arg Val Tyr Gln Gly Gln Gln Pro Gly Thr Cys Met Gly 
465                 470                 475                 480 
Ser Lys Arg Ser Gln Val Ser Ser Pro Cys Ser Arg Lys Lys Pro Arg 
                485                 490                 495     
Met Gly Gln Gln Val Leu Asp Asn Phe Phe Arg Ser His Ile Ser Thr 
            500                 505                 510         
Asp Ala His Ser Leu Asn Ser Ala Ala Gln 
        515                 520         

<210> 6
<211> 521
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1-Isoform Gamma-3

<400> 6
Met Arg Lys Pro Arg Ala Ala Val Gly Ser Gly His Arg Lys Gln Ala 
1               5                   10                  15      
Ala Ser Gln Glu Gly Arg Gln Lys His Ala Lys Asn Asn Ser Gln Ala 
            20                  25                  30          
Lys Pro Ser Ala Cys Asp Gly Leu Ala Arg Gln Pro Glu Glu Val Val 
        35                  40                  45              
Leu Gln Ala Ser Val Ser Ser Tyr His Leu Phe Arg Asp Val Ala Glu 
    50                  55                  60                  
Val Thr Ala Phe Arg Gly Ser Leu Leu Ser Trp Tyr Asp Gln Glu Lys 
65                  70                  75                  80  
Arg Asp Leu Pro Trp Arg Arg Arg Ala Glu Asp Glu Met Asp Leu Asp 
                85                  90                  95      
Arg Arg Ala Tyr Ala Val Trp Val Ser Glu Val Met Leu Gln Gln Thr 
            100                 105                 110         
Gln Val Ala Thr Val Ile Asn Tyr Tyr Thr Gly Trp Met Gln Lys Trp 
        115                 120                 125             
Pro Thr Leu Gln Asp Leu Ala Ser Ala Ser Leu Glu Glu Val Asn Gln 
    130                 135                 140                 
Leu Trp Ala Gly Leu Gly Tyr Tyr Ser Arg Gly Arg Arg Leu Gln Glu 
145                 150                 155                 160 
Gly Ala Arg Lys Val Val Glu Glu Leu Gly Gly His Met Pro Arg Thr 
                165                 170                 175     
Ala Glu Thr Leu Gln Gln Leu Leu Pro Gly Val Gly Arg Tyr Thr Ala 
            180                 185                 190         
Gly Ala Ile Ala Ser Ile Ala Phe Gly Gln Ala Thr Gly Val Val Asp 
        195                 200                 205             
Gly Asn Val Ala Arg Val Leu Cys Arg Val Arg Ala Ile Gly Ala Asp 
    210                 215                 220                 
Pro Ser Ser Thr Leu Val Ser Gln Gln Leu Trp Gly Leu Ala Gln Gln 
225                 230                 235                 240 
Leu Val Asp Pro Ala Arg Pro Gly Asp Phe Asn Gln Ala Ala Met Glu 
                245                 250                 255     
Leu Gly Ala Thr Val Cys Thr Pro Gln Arg Pro Leu Cys Ser Gln Cys 
            260                 265                 270         
Pro Val Glu Ser Leu Cys Arg Ala Arg Gln Arg Val Glu Gln Glu Gln 
        275                 280                 285             
Leu Leu Ala Ser Gly Ser Leu Ser Gly Ser Pro Asp Val Glu Glu Cys 
    290                 295                 300                 
Ala Pro Asn Thr Gly Gln Cys His Leu Cys Leu Pro Pro Ser Glu Pro 
305                 310                 315                 320 
Trp Asp Gln Thr Leu Gly Val Val Asn Phe Pro Arg Lys Ala Ser Arg 
                325                 330                 335     
Lys Pro Pro Arg Glu Glu Ser Ser Ala Thr Cys Val Leu Glu Gln Pro 
            340                 345                 350         
Gly Ala Leu Gly Ala Gln Ile Leu Leu Val Gln Arg Pro Asn Ser Gly 
        355                 360                 365             
Leu Leu Ala Gly Leu Trp Glu Phe Pro Ser Val Thr Trp Glu Pro Ser 
    370                 375                 380                 
Glu Gln Leu Gln Arg Lys Ala Leu Leu Gln Glu Leu Gln Arg Trp Ala 
385                 390                 395                 400 
Gly Pro Leu Pro Ala Thr His Leu Arg His Leu Gly Glu Val Val His 
                405                 410                 415     
Thr Phe Ser His Ile Lys Leu Thr Tyr Gln Val Tyr Gly Leu Ala Leu 
            420                 425                 430         
Glu Gly Gln Thr Pro Val Thr Thr Val Pro Pro Gly Ala Arg Trp Leu 
        435                 440                 445             
Thr Gln Glu Glu Phe His Thr Ala Ala Val Ser Thr Ala Met Lys Lys 
    450                 455                 460                 
Val Phe Arg Val Tyr Gln Gly Gln Gln Pro Gly Thr Cys Met Gly Ser 
465                 470                 475                 480 
Lys Arg Ser Gln Val Ser Ser Pro Cys Ser Arg Lys Lys Pro Arg Met 
                485                 490                 495     
Gly Gln Gln Val Leu Asp Asn Phe Phe Arg Ser His Ile Ser Thr Asp 
            500                 505                 510         
Ala His Ser Leu Asn Ser Ala Ala Gln 
        515                 520     

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer SUR1

<400> 7
agctgagagc gaggaggatg                                                20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer SUR1

<400> 8
cacttggcca gccagtagtc                                                20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer GAPDH

<400> 9
agaacatcat ccctgcatcc                                                20


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer GAPDH

<400> 10
acattggggg taggaacac                                                 19


