                         SEQUENCE LISTING

<110>  SIB SWISS INSTITUTE OF BIOINFORMATICS, CHUV - CENTRE 
       HOSPITALIER UNIVERSITAIRE VAUDOIS, UNIVERSITE DE LAUSANNE, LUDWIG
        INSTITUTE FOR CANCER RESEARCH LTD
 
<120>  KINASE MUTANTS AND USES THEREOF

<130>  P2039PC00

<150>  EP17172639.1
<151>  2017-05-24

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  2
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  3
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Z1 (mutated human Zap-70)

<400>  3

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Ala Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  4
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Z2 (mutated human Zap-70)

<400>  4

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Thr Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  5
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Z3 (mutated human Zap-70)

<400>  5

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Val Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  6
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Z8 (mutated human Zap-70)

<400>  6

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Val Glu Tyr 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  7
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Z9 (mutated human Zap-70)

<400>  7

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Ile Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Val Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  8
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Z10 (mutated human Zap-70)

<400>  8

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Ile Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Val Glu Tyr 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  9
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of mutated human Lck 7 (T316V)

<400>  9

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Val Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  10
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of mutated human Lck 2 (Y318L)

<400>  10

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Leu Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  11
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of mutated human Lck 1 (S323C)

<400>  11

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Cys Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  12
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence part of mutated Zap-70 (consensus)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is selected from Val and Ile

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is selected from Arg, Lys and His

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa3 is selected from Leu, Ile, Val, Met, Ala, Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa4 is selected from Ile, Leu, Val, Met, Ala, Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa5 is selected from Gly, Pro and Ala

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa6 is selected from Val, Ile, Met, Leu, Phe, Ala and Pro

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa7 is selected from Cys, Ser, Thr and Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa8 is selected from Gln and Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa9 is selected from Ala, Val, Leu, Ile and Pro

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa10 is selected from Glu and Asp

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa11 is selected from Ala, Val, Leu, Ile and Pro

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa12 is selected from Leu, Ile, Val, Met, Ala, Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa13 is selected from Met, Val, Leu, Ile and Phe

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa14 is selected from Leu, Ile, Val, Met, Ala, Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa15 is selected from Val, Ile, Met, Leu, Phe, Ala and Pro

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is selected from Met, Ala, Val, and Thr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa17 is selected from Glu and Asp

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa18 is selected from Met, Tyr and Leu

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa19 is selected from Ala, Val, Leu, Ile and Pro

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa20 is selected from Gly, Pro and Ala

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is selected from Gly, Pro and Ala

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa22 is selected from Gly, Pro and Ala

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa23 is selected from Pro, Ala and Gly

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is selected from Leu, Ile, Val, Met, Ala, Phe and Tyr

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is selected from His, Lys and Arg

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa26 is selected from Lys, Arg and His

<400>  12

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25      


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence part of mutated Lck (consensus)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xab1 is selected from Thr, Val and Ser

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xab2 is selected from Glu and Asp

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xab3 is selected from Tyr and Leu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xab4 is selected from Met, Val, Leu, Ile and Phe

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xab5 is selected from Glu and Asp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xab6 is selected from Asn and Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xab7 is selected from Gly, Pro and Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xab8 is selected from Ser, Cys, Thr and Ala

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xab9 is selected from Leu, Ile, Val, Met, Ala, Phe and Tyr

<400>  13

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  14
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Z1 (5'- 3'; mutated human Zap-70)

<400>  14
atgcctgatc ctgccgccca tctgccattc ttctacggca gcatcagcag agccgaggcc       60

gaggaacacc tgaagctggc cggaatggcc gacggcctgt tcctgctgag acagtgcctg      120

agaagcctgg gcggctacgt gctgagcctg gtgcacgatg tgcggttcca ccacttcccc      180

atcgagcggc agctgaacgg cacctacgct atcgctggcg gcaaggccca ttgtggacct      240

gccgagctgt gcgagttcta cagcagagat cccgatggcc tgccctgcaa cctgcggaag      300

ccctgcaata gacccagcgg cctggaacct cagcccggcg tgttcgactg tctgagggat      360

gccatggtgc gcgactacgt gcggcagacc tggaagctgg aaggcgaggc tctggaacag      420

gctatcatca gccaggcccc ccaggtggaa aagctgatcg ccacaaccgc ccacgagcgg      480

atgccctggt atcacagcag cctgaccaga gaggaagccg agcggaagct gtactctggc      540

gcccagaccg acggcaaatt cctgctgcgg cccagaaaag agcagggcac atacgccctg      600

agcctgatct acggcaagac cgtgtaccac tacctgatct cccaggacaa ggccggcaag      660

tactgcatcc ccgagggcac caagttcgac accctgtggc agctggtgga atatctgaag      720

ctgaaggccg acggactgat ctactgcctg aaagaggcct gccccaacag cagcgccagc      780

aatgctagcg gagccgccgc tcctacactg cctgcccatc ctagcaccct gacccacccc      840

cagagaagaa tcgataccct gaattccgac ggctacaccc ccgagcctgc cagaatcacc      900

agccccgaca agcccagacc catgcccatg gacaccagcg tgtacgagag cccctacagc      960

gaccccgagg aactgaagga caagaagctg ttcctgaagc gggacaacct gctgattgcc     1020

gacatcgagc tgggctgcgg caactttgga tctgtgcggc agggcgtgta ccggatgcgg     1080

aagaaacaga tcgacgtggc catcaaggtg ctgaagcagg gaaccgagaa ggccgatacc     1140

gaggaaatga tgcgcgaggc ccagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctgatcggcg tgtgtcaggc cgaagctctg atgctcgtgg ccgaaatggc tggcggcgga     1260

cccctgcaca agtttctcgt gggcaagcgg gaagagatcc ccgtgtccaa tgtggccgag     1320

ctgctgcacc aggtgtcaat gggaatgaag tacctcgagg agaagaactt cgtgcaccgg     1380

gacctggccg ccagaaacgt gctgctcgtg aaccggcact acgccaagat cagcgacttt     1440

ggcctgagca aggccctggg cgccgacgac agctactaca cagccagatc cgccggaaag     1500

tggcccctga agtggtacgc ccccgagtgc atcaacttca gaaagttcag cagccgcagc     1560

gacgtgtggt cctacggcgt gacaatgtgg gaggccctga gctacggcca gaaaccctac     1620

aagaagatga agggccccga agtgatggcc ttcatcgagc agggaaagcg gatggaatgc     1680

ccccctgagt gccctcctga gctgtatgcc ctgatgagcg actgctggat ctacaagtgg     1740

gaggaccggc ccgacttcct gaccgtggaa cagagaatgc gggcctgcta ctacagcctg     1800

gcctctaagg tggaaggccc tcctggcagc acccagaaag ccgaagccgc ctgtgct        1857


<210>  15
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Z2 (5'- 3'; mutated human Zap-70)

<400>  15
atgcctgatc ctgccgccca tctgccattc ttctacggca gcatcagcag agccgaggcc       60

gaggaacacc tgaagctggc cggaatggcc gacggcctgt tcctgctgag acagtgcctg      120

agaagcctgg gcggctacgt gctgagcctg gtgcacgatg tgcggttcca ccacttcccc      180

atcgagcggc agctgaacgg cacctacgct atcgctggcg gcaaggccca ttgtggacct      240

gccgagctgt gcgagttcta cagcagagat cccgatggcc tgccctgcaa cctgcggaag      300

ccctgcaata gacccagcgg cctggaacct cagcccggcg tgttcgactg tctgagggat      360

gccatggtgc gcgactacgt gcggcagacc tggaagctgg aaggcgaggc tctggaacag      420

gctatcatca gccaggcccc ccaggtggaa aagctgatcg ccacaaccgc ccacgagcgg      480

atgccctggt atcacagcag cctgaccaga gaggaagccg agcggaagct gtactctggc      540

gcccagaccg acggcaaatt cctgctgcgg cccagaaaag agcagggcac atacgccctg      600

agcctgatct acggcaagac cgtgtaccac tacctgatct cccaggacaa ggccggcaag      660

tactgcatcc ccgagggcac caagttcgac accctgtggc agctggtgga atatctgaag      720

ctgaaggccg acggactgat ctactgcctg aaagaggcct gccccaacag cagcgccagc      780

aatgctagcg gagccgccgc tcctacactg cctgcccatc ctagcaccct gacccacccc      840

cagagaagaa tcgataccct gaattccgac ggctacaccc ccgagcctgc cagaatcacc      900

agccccgaca agcccagacc catgcccatg gacaccagcg tgtacgagag cccctacagc      960

gaccccgagg aactgaagga caagaagctg ttcctgaagc gggacaacct gctgattgcc     1020

gacatcgagc tgggctgcgg caactttgga tctgtgcggc agggcgtgta ccggatgcgg     1080

aagaaacaga tcgacgtggc catcaaggtg ctgaagcagg gaaccgagaa ggccgatacc     1140

gaggaaatga tgcgcgaggc ccagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctgatcggcg tgtgtcaggc cgaagctctg atgctcgtga ccgaaatggc tggcggcgga     1260

cccctgcaca agtttctcgt gggcaagcgg gaagagatcc ccgtgtccaa tgtggccgag     1320

ctgctgcacc aggtgtcaat gggaatgaag tacctcgagg agaagaactt cgtgcaccgg     1380

gacctggccg ccagaaacgt gctgctcgtg aaccggcact acgccaagat cagcgacttt     1440

ggcctgagca aggccctggg cgccgacgac agctactaca cagccagatc cgccggaaag     1500

tggcccctga agtggtacgc ccccgagtgc atcaacttca gaaagttcag cagccgcagc     1560

gacgtgtggt cctacggcgt gacaatgtgg gaggccctga gctacggcca gaaaccctac     1620

aagaagatga agggccccga agtgatggcc ttcatcgagc agggaaagcg gatggaatgc     1680

ccccctgagt gccctcctga gctgtatgcc ctgatgagcg actgctggat ctacaagtgg     1740

gaggaccggc ccgacttcct gaccgtggaa cagagaatgc gggcctgcta ctacagcctg     1800

gcctctaagg tggaaggccc tcctggcagc acccagaaag ccgaagccgc ctgtgct        1857


<210>  16
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Z3 (5'- 3'; mutated human Zap-70)

<400>  16
atgcctgatc ctgccgccca tctgccattc ttctacggca gcatcagcag agccgaggcc       60

gaggaacacc tgaagctggc cggaatggcc gacggcctgt tcctgctgag acagtgcctg      120

agaagcctgg gcggctacgt gctgagcctg gtgcacgatg tgcggttcca ccacttcccc      180

atcgagcggc agctgaacgg cacctacgct atcgctggcg gcaaggccca ttgtggacct      240

gccgagctgt gcgagttcta cagcagagat cccgatggcc tgccctgcaa cctgcggaag      300

ccctgcaata gacccagcgg cctggaacct cagcccggcg tgttcgactg tctgagggat      360

gccatggtgc gcgactacgt gcggcagacc tggaagctgg aaggcgaggc tctggaacag      420

gctatcatca gccaggcccc ccaggtggaa aagctgatcg ccacaaccgc ccacgagcgg      480

atgccctggt atcacagcag cctgaccaga gaggaagccg agcggaagct gtactctggc      540

gcccagaccg acggcaaatt cctgctgcgg cccagaaaag agcagggcac atacgccctg      600

agcctgatct acggcaagac cgtgtaccac tacctgatct cccaggacaa ggccggcaag      660

tactgcatcc ccgagggcac caagttcgac accctgtggc agctggtgga atatctgaag      720

ctgaaggccg acggactgat ctactgcctg aaagaggcct gccccaacag cagcgccagc      780

aatgctagcg gagccgccgc tcctacactg cctgcccatc ctagcaccct gacccacccc      840

cagagaagaa tcgataccct gaattccgac ggctacaccc ccgagcctgc cagaatcacc      900

agccccgaca agcccagacc catgcccatg gacaccagcg tgtacgagag cccctacagc      960

gaccccgagg aactgaagga caagaagctg ttcctgaagc gggacaacct gctgattgcc     1020

gacatcgagc tgggctgcgg caactttgga tctgtgcggc agggcgtgta ccggatgcgg     1080

aagaaacaga tcgacgtggc catcaaggtg ctgaagcagg gaaccgagaa ggccgatacc     1140

gaggaaatga tgcgcgaggc ccagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctgatcggcg tgtgtcaggc cgaagctctg atgctcgtgg tcgaaatggc tggcggcgga     1260

cccctgcaca agtttctcgt gggcaagcgg gaagagatcc ccgtgtccaa tgtggccgag     1320

ctgctgcacc aggtgtcaat gggaatgaag tacctcgagg agaagaactt cgtgcaccgg     1380

gacctggccg ccagaaacgt gctgctcgtg aaccggcact acgccaagat cagcgacttt     1440

ggcctgagca aggccctggg cgccgacgac agctactaca cagccagatc cgccggaaag     1500

tggcccctga agtggtacgc ccccgagtgc atcaacttca gaaagttcag cagccgcagc     1560

gacgtgtggt cctacggcgt gacaatgtgg gaggccctga gctacggcca gaaaccctac     1620

aagaagatga agggccccga agtgatggcc ttcatcgagc agggaaagcg gatggaatgc     1680

ccccctgagt gccctcctga gctgtatgcc ctgatgagcg actgctggat ctacaagtgg     1740

gaggaccggc ccgacttcct gaccgtggaa cagagaatgc gggcctgcta ctacagcctg     1800

gcctctaagg tggaaggccc tcctggcagc acccagaaag ccgaagccgc ctgtgct        1857


<210>  17
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Z8 (5'- 3'; mutated human Zap-70)

<400>  17
atgcctgatc ctgccgccca tctgccattc ttctacggca gcatcagcag agccgaggcc       60

gaggaacacc tgaagctggc cggaatggcc gacggcctgt tcctgctgag acagtgcctg      120

agaagcctgg gcggctacgt gctgagcctg gtgcacgatg tgcggttcca ccacttcccc      180

atcgagcggc agctgaacgg cacctacgct atcgctggcg gcaaggccca ttgtggacct      240

gccgagctgt gcgagttcta cagcagagat cccgatggcc tgccctgcaa cctgcggaag      300

ccctgcaata gacccagcgg cctggaacct cagcccggcg tgttcgactg tctgagggat      360

gccatggtgc gcgactacgt gcggcagacc tggaagctgg aaggcgaggc tctggaacag      420

gctatcatca gccaggcccc ccaggtggaa aagctgatcg ccacaaccgc ccacgagcgg      480

atgccctggt atcacagcag cctgaccaga gaggaagccg agcggaagct gtactctggc      540

gcccagaccg acggcaaatt cctgctgcgg cccagaaaag agcagggcac atacgccctg      600

agcctgatct acggcaagac cgtgtaccac tacctgatct cccaggacaa ggccggcaag      660

tactgcatcc ccgagggcac caagttcgac accctgtggc agctggtgga atatctgaag      720

ctgaaggccg acggactgat ctactgcctg aaagaggcct gccccaacag cagcgccagc      780

aatgctagcg gagccgccgc tcctacactg cctgcccatc ctagcaccct gacccacccc      840

cagagaagaa tcgataccct gaattccgac ggctacaccc ccgagcctgc cagaatcacc      900

agccccgaca agcccagacc catgcccatg gacaccagcg tgtacgagag cccctacagc      960

gaccccgagg aactgaagga caagaagctg ttcctgaagc gggacaacct gctgattgcc     1020

gacatcgagc tgggctgcgg caactttgga tctgtgcggc agggcgtgta ccggatgcgg     1080

aagaaacaga tcgacgtggc catcaaggtg ctgaagcagg gaaccgagaa ggccgatacc     1140

gaggaaatga tgcgcgaggc ccagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctgatcggcg tgtgtcaggc cgaagctctg atgctcgtgg tcgaatacgc tggcggcgga     1260

cccctgcaca agtttctcgt gggcaagcgg gaagagatcc ccgtgtccaa tgtggccgag     1320

ctgctgcacc aggtgtcaat gggaatgaag tacctcgagg agaagaactt cgtgcaccgg     1380

gacctggccg ccagaaacgt gctgctcgtg aaccggcact acgccaagat cagcgacttt     1440

ggcctgagca aggccctggg cgccgacgac agctactaca cagccagatc cgccggaaag     1500

tggcccctga agtggtacgc ccccgagtgc atcaacttca gaaagttcag cagccgcagc     1560

gacgtgtggt cctacggcgt gacaatgtgg gaggccctga gctacggcca gaaaccctac     1620

aagaagatga agggccccga agtgatggcc ttcatcgagc agggaaagcg gatggaatgc     1680

ccccctgagt gccctcctga gctgtatgcc ctgatgagcg actgctggat ctacaagtgg     1740

gaggaccggc ccgacttcct gaccgtggaa cagagaatgc gggcctgcta ctacagcctg     1800

gcctctaagg tggaaggccc tcctggcagc acccagaaag ccgaagccgc ctgtgct        1857


<210>  18
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Z9 (5'- 3'; mutated human Zap-70)

<400>  18
atgcctgatc ctgccgccca tctgccattc ttctacggca gcatcagcag agccgaggcc       60

gaggaacacc tgaagctggc cggaatggcc gacggcctgt tcctgctgag acagtgcctg      120

agaagcctgg gcggctacgt gctgagcctg gtgcacgatg tgcggttcca ccacttcccc      180

atcgagcggc agctgaacgg cacctacgct atcgctggcg gcaaggccca ttgtggacct      240

gccgagctgt gcgagttcta cagcagagat cccgatggcc tgccctgcaa cctgcggaag      300

ccctgcaata gacccagcgg cctggaacct cagcccggcg tgttcgactg tctgagggat      360

gccatggtgc gcgactacgt gcggcagacc tggaagctgg aaggcgaggc tctggaacag      420

gctatcatca gccaggcccc ccaggtggaa aagctgatcg ccacaaccgc ccacgagcgg      480

atgccctggt atcacagcag cctgaccaga gaggaagccg agcggaagct gtactctggc      540

gcccagaccg acggcaaatt cctgctgcgg cccagaaaag agcagggcac atacgccctg      600

agcctgatct acggcaagac cgtgtaccac tacctgatct cccaggacaa ggccggcaag      660

tactgcatcc ccgagggcac caagttcgac accctgtggc agctggtgga atatctgaag      720

ctgaaggccg acggactgat ctactgcctg aaagaggcct gccccaacag cagcgccagc      780

aatgctagcg gagccgccgc tcctacactg cctgcccatc ctagcaccct gacccacccc      840

cagagaagaa tcgataccct gaattccgac ggctacaccc ccgagcctgc cagaatcacc      900

agccccgaca agcccagacc catgcccatg gacaccagcg tgtacgagag cccctacagc      960

gaccccgagg aactgaagga caagaagctg ttcctgaagc gggacaacct gctgattgcc     1020

gacatcgagc tgggctgcgg caactttgga tctgtgcggc agggcgtgta ccggatgcgg     1080

aagaaacaga tcgacgtggc catcaaggtg ctgaagcagg gaaccgagaa ggccgatacc     1140

gaggaaatga tgcgcgaggc ccagatcatg caccagctgg acaaccccta catcattcgg     1200

ctgatcggcg tgtgtcaggc cgaagctctg atgctcgtgg tcgaaatggc tggcggcgga     1260

cccctgcaca agtttctcgt gggcaagcgg gaagagatcc ccgtgtccaa tgtggccgag     1320

ctgctgcacc aggtgtcaat gggaatgaag tacctcgagg agaagaactt cgtgcaccgg     1380

gacctggccg ccagaaacgt gctgctcgtg aaccggcact acgccaagat cagcgacttt     1440

ggcctgagca aggccctggg cgccgacgac agctactaca cagccagatc cgccggaaag     1500

tggcccctga agtggtacgc ccccgagtgc atcaacttca gaaagttcag cagccgcagc     1560

gacgtgtggt cctacggcgt gacaatgtgg gaggccctga gctacggcca gaaaccctac     1620

aagaagatga agggccccga agtgatggcc ttcatcgagc agggaaagcg gatggaatgc     1680

ccccctgagt gccctcctga gctgtatgcc ctgatgagcg actgctggat ctacaagtgg     1740

gaggaccggc ccgacttcct gaccgtggaa cagagaatgc gggcctgcta ctacagcctg     1800

gcctctaagg tggaaggccc tcctggcagc acccagaaag ccgaagccgc ctgtgct        1857


<210>  19
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of Z10 (5'- 3'; mutated human Zap-70)

<400>  19
atgcctgatc ctgccgccca tctgccattc ttctacggca gcatcagcag agccgaggcc       60

gaggaacacc tgaagctggc cggaatggcc gacggcctgt tcctgctgag acagtgcctg      120

agaagcctgg gcggctacgt gctgagcctg gtgcacgatg tgcggttcca ccacttcccc      180

atcgagcggc agctgaacgg cacctacgct atcgctggcg gcaaggccca ttgtggacct      240

gccgagctgt gcgagttcta cagcagagat cccgatggcc tgccctgcaa cctgcggaag      300

ccctgcaata gacccagcgg cctggaacct cagcccggcg tgttcgactg tctgagggat      360

gccatggtgc gcgactacgt gcggcagacc tggaagctgg aaggcgaggc tctggaacag      420

gctatcatca gccaggcccc ccaggtggaa aagctgatcg ccacaaccgc ccacgagcgg      480

atgccctggt atcacagcag cctgaccaga gaggaagccg agcggaagct gtactctggc      540

gcccagaccg acggcaaatt cctgctgcgg cccagaaaag agcagggcac atacgccctg      600

agcctgatct acggcaagac cgtgtaccac tacctgatct cccaggacaa ggccggcaag      660

tactgcatcc ccgagggcac caagttcgac accctgtggc agctggtgga atatctgaag      720

ctgaaggccg acggactgat ctactgcctg aaagaggcct gccccaacag cagcgccagc      780

aatgctagcg gagccgccgc tcctacactg cctgcccatc ctagcaccct gacccacccc      840

cagagaagaa tcgataccct gaattccgac ggctacaccc ccgagcctgc cagaatcacc      900

agccccgaca agcccagacc catgcccatg gacaccagcg tgtacgagag cccctacagc      960

gaccccgagg aactgaagga caagaagctg ttcctgaagc gggacaacct gctgattgcc     1020

gacatcgagc tgggctgcgg caactttgga tctgtgcggc agggcgtgta ccggatgcgg     1080

aagaaacaga tcgacgtggc catcaaggtg ctgaagcagg gaaccgagaa ggccgatacc     1140

gaggaaatga tgcgcgaggc ccagatcatg caccagctgg acaaccccta catcattcgg     1200

ctgatcggcg tgtgtcaggc cgaagctctg atgctcgtgg tcgaatacgc tggcggcgga     1260

cccctgcaca agtttctcgt gggcaagcgg gaagagatcc ccgtgtccaa tgtggccgag     1320

ctgctgcacc aggtgtcaat gggaatgaag tacctcgagg agaagaactt cgtgcaccgg     1380

gacctggccg ccagaaacgt gctgctcgtg aaccggcact acgccaagat cagcgacttt     1440

ggcctgagca aggccctggg cgccgacgac agctactaca cagccagatc cgccggaaag     1500

tggcccctga agtggtacgc ccccgagtgc atcaacttca gaaagttcag cagccgcagc     1560

gacgtgtggt cctacggcgt gacaatgtgg gaggccctga gctacggcca gaaaccctac     1620

aagaagatga agggccccga agtgatggcc ttcatcgagc agggaaagcg gatggaatgc     1680

ccccctgagt gccctcctga gctgtatgcc ctgatgagcg actgctggat ctacaagtgg     1740

gaggaccggc ccgacttcct gaccgtggaa cagagaatgc gggcctgcta ctacagcctg     1800

gcctctaagg tggaaggccc tcctggcagc acccagaaag ccgaagccgc ctgtgct        1857


<210>  20
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of mutated human Lck 4 (S323C + Y318L)

<400>  20

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Leu Met Glu 
305                 310                 315                 320 


Asn Gly Cys Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


