                         SEQUENCE LISTING

<110>  Universitat Autnoma de Barcelona
 
<120>  Viral expression construct comprising a Fibroblast Growth Factor 
       21 (FGF21) coding sequence

<130>  P6066689PCT

<150>  EP17172818.1 
<151>  24-05-2017

<150>  ES201700615
<151>  24-05-2017

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  2
<211>  210
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Trp Met Arg Ser Arg Val Gly Thr Leu Gly Leu Trp Val Arg 
1               5                   10                  15      


Leu Leu Leu Ala Val Phe Leu Leu Gly Val Tyr Gln Ala Tyr Pro Ile 
            20                  25                  30          


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Ala Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Ala Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Pro Asn Gln Asp Ala Thr Ser Trp 
145                 150                 155                 160 


Gly Pro Val Arg Phe Leu Pro Met Pro Gly Leu Leu His Glu Pro Gln 
                165                 170                 175     


Asp Gln Ala Gly Phe Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser 
            180                 185                 190         


Asp Pro Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr 
        195                 200                 205             


Ala Ser 
    210 


<210>  3
<211>  209
<212>  PRT
<213>  Canis lupus familiaris

<400>  3

Met Gly Trp Ala Glu Ala Gly Phe Glu His Leu Gly Leu Trp Val Pro 
1               5                   10                  15      


Val Leu Ala Val Leu Leu Leu Glu Ala Cys Arg Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Ala Asp Gly Thr Val Val Gly Ala Ala Arg Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Gly Pro Asp Gly Thr Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Val Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Ile Tyr His Ser Glu Thr Leu Gly Leu Pro Leu 
    130                 135                 140                 


Arg Leu Arg Pro His Asn Ser Ala Tyr Arg Asp Leu Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Leu Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Glu Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  4
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  4
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt       60

cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc      120

gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac      180

ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc      240

ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg      300

ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc      360

tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac      420

ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga      480

ccagctcgct tcctgccact accaggcctg ccccccgcac tcccggagcc acccggaatc      540

ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc      600

cagggccgaa gccccagcta cgcttcctga                                       630


<210>  5
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Homo sapiens FGF21 - variant 1

<400>  5
atggattctg atgagacagg cttcgagcac agcggcctgt gggtttcagt tctggctgga       60

ctgctgctgg gagcctgtca ggcacaccct attccagata gcagccctct gctgcagttc      120

ggcggacaag tgcggcagag atacctgtac accgacgacg cccagcagac agaagcccac      180

ctggaaatca gagaggatgg cacagttggc ggagccgccg atcagtctcc tgaatctctg      240

ctccagctga aggccctgaa gcctggcgtg atccagatcc tgggcgtgaa aaccagccgg      300

ttcctgtgcc aaagacctga cggcgccctg tatggcagcc tgcactttga tcctgaggcc      360

tgcagcttca gagagctgct gcttgaggac ggctacaacg tgtaccagtc tgaggcccat      420

ggcctgcctc tgcatctgcc tggaaacaag agccctcaca gagatcccgc tcctagaggc      480

cctgccagat ttctgcctct tcctggattg cctcctgctc tgccagagcc tcctggaatt      540

ctggctcctc agcctcctga tgtgggcagc tctgatcctc tgagcatggt cggacctagc      600

cagggcagat ctcctagcta cgcctcttga                                       630


<210>  6
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Homo sapiens FGF21 - variant 2

<400>  6
atggacagcg atgaaaccgg gttcgagcac agcggtctgt gggtgtccgt gctggccgga       60

ctgctcctgg gagcctgtca ggcgcacccc atccctgact cctcgccgct gctgcaattc      120

ggcggacaag tccgccagag atacctgtac accgacgacg cccagcagac cgaagcccac      180

ctggaaattc gggaggacgg gactgtggga ggcgctgcag atcagtcacc cgagtccctc      240

ctccaactga aggccttgaa gcccggcgtg attcagatcc tgggcgtgaa aacttcccgc      300

ttcctttgcc aacggccgga tggagctctg tacggatccc tgcacttcga ccccgaagcc      360

tgctcattcc gcgagctgct ccttgaggac ggctataacg tgtaccagtc tgaggcccat      420

ggactccccc tgcatctgcc cggcaacaag tcccctcacc gggatcctgc cccaagaggc      480

ccagctcggt ttctgcctct gccgggactg cctccagcgt tgcccgaacc ccctggtatc      540

ctggccccgc aaccacctga cgtcggttcg tcggacccgc tgagcatggt cggtccgagc      600

cagggaaggt ccccgtccta cgcatcctga                                       630


<210>  7
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Homo sapiens FGF21 - variant 3

<400>  7
atggattccg acgaaactgg atttgaacat tcagggctgt gggtctctgt gctggctgga       60

ctgctgctgg gggcttgtca ggctcacccc atccctgaca gctcccctct gctgcagttc      120

ggaggacagg tgcggcagag atacctgtat accgacgatg cccagcagac agaggcacac      180

ctggagatca gggaggacgg aaccgtggga ggagcagccg atcagtctcc cgagagcctg      240

ctgcagctga aggccctgaa gcctggcgtg atccagatcc tgggcgtgaa gacatctcgg      300

tttctgtgcc agcggcccga cggcgccctg tacggctccc tgcacttcga tcccgaggcc      360

tgttctttta gggagctgct gctggaggac ggctacaacg tgtatcagag cgaggcacac      420

ggcctgccac tgcacctgcc tggcaataag tcccctcacc gcgatccagc acccaggggc      480

ccagcacgct tcctgcctct gccaggcctg ccccctgccc tgccagagcc acccggcatc      540

ctggcccccc agcctccaga tgtgggctcc agcgatcctc tgtcaatggt ggggccaagt      600

caggggcgga gtccttcata cgcatcataa                                       630


<210>  8
<211>  633
<212>  DNA
<213>  Mus musculus

<400>  8
atggaatgga tgagatctag agttgggacc ctgggactgt gggtccgact gctgctggct       60

gtcttcctgc tgggggtcta ccaagcatac cccatccctg actccagccc cctcctccag      120

tttgggggtc aagtccggca gaggtacctc tacacagatg acgaccaaga cactgaagcc      180

cacctggaga tcagggagga tggaacagtg gtaggcgcag cacaccgcag tccagaaagt      240

ctcctggagc tcaaagcctt gaagccaggg gtcattcaaa tcctgggtgt caaagcctct      300

aggtttcttt gccaacagcc agatggagct ctctatggat cgcctcactt tgatcctgag      360

gcctgcagct tcagagaact gctgctggag gacggttaca atgtgtacca gtctgaagcc      420

catggcctgc ccctgcgtct gcctcagaag gactccccaa accaggatgc aacatcctgg      480

ggacctgtgc gcttcctgcc catgccaggc ctgctccacg agccccaaga ccaagcagga      540

ttcctgcccc cagagccccc agatgtgggc tcctctgacc ccctgagcat ggtagagcct      600

ttacagggcc gaagccccag ctatgcgtcc tga                                   633


<210>  9
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized Mus musculus FGF21

<400>  9
atggaatgga tgagaagcag agtgggcacc ctgggcctgt gggtgcgact gctgctggct       60

gtgtttctgc tgggcgtgta ccaggcctac cccatccctg actctagccc cctgctgcag      120

tttggcggac aagtgcggca gagatacctg tacaccgacg acgaccagga caccgaggcc      180

cacctggaaa tccgcgagga tggcacagtc gtgggcgctg ctcacagaag ccctgagagc      240

ctgctggaac tgaaggccct gaagcccggc gtgatccaga tcctgggcgt gaaggccagc      300

agattcctgt gccagcagcc tgacggcgcc ctgtacggct ctcctcactt cgatcctgag      360

gcctgcagct tcagagagct gctgctggag gacggctaca acgtgtacca gtctgaggcc      420

cacggcctgc ccctgagact gcctcagaag gacagcccta accaggacgc cacaagctgg      480

ggacctgtgc ggttcctgcc tatgcctgga ctgctgcacg agccccagga tcaggctggc      540

tttctgcctc ctgagcctcc agacgtgggc agcagcgacc ctctgagcat ggtggaacct      600

ctgcagggca gaagccccag ctacgcctct tga                                   633


<210>  10
<211>  629
<212>  DNA
<213>  Canis lupus familiaris

<400>  10
atgggctggg ccgaggccgg gttcgagcac ctgggactgt gggtccctgt gctggctgtg       60

cttttgctgg aagcctgccg ggcacatccg atccctgact ccagccccct cctacaattt      120

ggaggtcaag ttcgacagcg gtacctctac accgacgatg cccaggagac agaggcccac      180

ctagagatca gggccgatgg cacagggtgg gggctgcccg ccagagccct gaaagtctcc      240

tggagctgaa agccctaaag ccaggggtca ttcaaatctt gggagtcaaa acatccaggt      300

tcctgtgcca gggcccagat gggacactat atggctcgct ccatttcgac cctgtggcct      360

gcagtttccg agaactgctt cttgaggatg ggtacaacat ctaccactcc gagacccttg      420

gtctcccgct tcgcctgcgc ccccacaact ccgcataccg ggacttggca ccccgcgggc      480

ctgcccgctt cctgccactg ccaggcctgc ttccagcacc cccagagcct ccagggatcc      540

tggccccgga gcctcctgac gtgggctcct cggaccctct gagcatggtg gggccttcac      600

agggccggag tcccagctat gcttcctaa                                        629


<210>  11
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Canis lupus familiaris FGF21

<400>  11
atgggatggg ctgaggctgg attcgaacac ctgggactct gggtgcccgt cctggccgtg       60

ctgctcctgg aggcttgcag ggctcatccc atccctgaca gctccccact cctgcagttt      120

ggaggacagg tgaggcagcg gtacctgtat accgacgatg cccaggagac agaagctcac      180

ctggaaattc gggctgatgg aacagtggtc ggagctgccc gacagtcccc agagtctctc      240

ctggaactga aggccctcaa acccggagtg atccagattc tgggcgtcaa gacttctaga      300

ttcctgtgcc agggaccaga cggcaccctg tacggcagcc tgcatttcga tcctgtggcc      360

tgttcctttc gagagctcct gctcgaagac ggctacaaca tctatcactc tgagaccctg      420

ggactcccac tgcgactcag acctcataat agtgcctatc gagatctggc tcccaggggc      480

ccagctaggt ttctgccact ccccggactg ctccctgctc cacctgagcc acccggcatt      540

ctggctccag aacctccaga cgtgggctct agtgatccac tgagtatggt cggcccctca      600

caggggaggt cacctagcta cgccagctga                                       630


<210>  12
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT122a

<400>  12
caaacaccat tgtcacactc ca                                                22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT1

<400>  13
ttacatactt ctttacattc ca                                                22


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT152

<400>  14
ccaagttctg tcatgcactg a                                                 21


<210>  15
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT199a-5p

<400>  15
gaacaggtag tctgaacact ggg                                               23


<210>  16
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT199a-3p

<400>  16
taaccaatgt gcagactact gt                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT215

<400>  17
gtctgtcaat tcataggtca t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT192

<400>  18
ggctgtcaat tcataggtca g                                                 21


<210>  19
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT148a

<400>  19
acaaagttct gtagtgcact ga                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT194

<400>  20
tccacatgga gttgctgtta ca                                                22


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT124

<400>  21
ggcattcacc gcgtgcctta                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT216

<400>  22
tcacagttgc cagctgagat ta                                                22


<210>  23
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT125

<400>  23
tcacaggtta aagggtctca ggga                                              24


<210>  24
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT133a

<400>  24
cagctggttg aaggggacca aa                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT206

<400>  25
ccacacactt ccttacattc ca                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT130

<400>  26
atgccctttt aacattgcac tg                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT99

<400>  27
cacaagatcg gatctacggg tt                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT208a-5p

<400>  28
gtataacccg ggccaaaagc tc                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT208a-3p

<400>  29
acaagctttt tgctcgtctt at                                                22


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide sequence encoding miRT499-5p

<400>  30
aaacatcact gcaagtctta a                                                 21


<210>  31
<211>  6343
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-null

<400>  31
aattcgagct cggtacccgg gaatcaattc actcctcagg tgcaggctgc ctatcagaag       60

gtggtggctg gtgtggccaa tgccctggct cacaaatacc actgagatct ttttccctct      120

gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg      180

aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact cggaaggaca      240

tatgggaggg caaatcattt aaaacatcag aatgagtatt tggtttagag tttggcaaca      300

tatgcccata tgctggctgc catgaacaaa ggttggctat aaagaggtca tcagtatatg      360

aaacagcccc ctgctgtcca ttccttattc catagaaaag ccttgacttg aggttagatt      420

ttttttatat tttgttttgt gttatttttt tctttaacat ccctaaaatt ttccttacat      480

gttttactag ccagattttt cctcctctcc tgactactcc cagtcatagc tgtccctctt      540

ctcttatgga gatccctcga cctgcagccc aagctgtaga taagtagcat ggcgggttaa      600

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct      660

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct      720

cagtgagcga gcgagcgcgc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg      780

tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg      840

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg      900

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa      960

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     1020

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     1080

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     1140

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     1200

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     1260

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     1320

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     1380

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     1440

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     1500

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     1560

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     1620

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     1680

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     1740

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     1800

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     1860

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     1920

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     1980

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     2040

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     2100

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     2160

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     2220

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     2280

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     2340

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat     2400

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     2460

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt     2520

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     2580

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     2640

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     2700

gcgcacattt ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt     2760

aacctataaa aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg     2820

tgaaaacctc tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc     2880

cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct     2940

taactatgcg gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc     3000

gcacagatgc gtaaggagaa aataccgcat caggcgattc caacatccaa taaatcatac     3060

aggcaaggca aagaattagc aaaattaagc aataaagcct cagagcataa agctaaatcg     3120

gttgtaccaa aaacattatg accctgtaat acttttgcgg gagaagcctt tatttcaacg     3180

caaggataaa aatttttaga accctcatat attttaaatg caatgcctga gtaatgtgta     3240

ggtaaagatt caaacgggtg agaaaggccg gagacagtca aatcaccatc aatatgatat     3300

tcaaccgttc tagctgataa attcatgccg gagagggtag ctatttttga gaggtctcta     3360

caaaggctat caggtcattg cctgagagtc tggagcaaac aagagaatcg atgaacggta     3420

atcgtaaaac tagcatgtca atcatatgta ccccggttga taatcagaaa agccccaaaa     3480

acaggaagat tgtataagca aatatttaaa ttgtaagcgt taatattttg ttaaaattcg     3540

cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc     3600

cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt tggaacaaga     3660

gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg     3720

atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg tgccgtaaag     3780

cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga     3840

acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg     3900

tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg     3960

cgtactatgg ttgctttgac gagcacgtat aacgtgcttt cctcgttaga atcagagcgg     4020

gagctaaaca ggaggccgat taaagggatt ttagacagga acggtacgcc agaatcctga     4080

gaagtgtttt tataatcagt gaggccaccg agtaaaagag tctgtccatc acgcaaatta     4140

accgttgtcg caatacttct ttgattagta ataacatcac ttgcctgagt agaagaactc     4200

aaactatcgg ccttgctggt aatatccaga acaatattac cgccagccat tgcaacggaa     4260

tcgccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc     4320

gctattacgc cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg     4380

tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc     4440

caactccatc actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac     4500

tcgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag     4560

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc     4620

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg     4680

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca     4740

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc     4800

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt     4860

attagtcatc gctattacca tggtcgaggt gagccccacg ttctgcttca ctctccccat     4920

ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat tttgtgcagc     4980

gatgggggcg gggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg     5040

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt     5100

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc     5160

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc     5220

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc     5280

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa     5340

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg     5400

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct     5460

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     5520

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     5580

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     5640

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     5700

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     5760

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     5820

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     5880

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     5940

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     6000

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     6060

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     6120

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     6180

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg attaattcga     6240

gcgaacgcgt cgagtcgctc ggtacgattt aaattgaatt ggcctcgagc gcaagcttga     6300

gctagctcga tatcggccta ggctggatcc gcgcggccgc aag                       6343


<210>  32
<211>  7319
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-moFGF21-dmiRT

<400>  32
agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt       60

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      120

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      180

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      240

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      300

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      360

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      420

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      480

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      540

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      600

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      660

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      720

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      780

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga      840

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca      900

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat      960

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1020

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     1080

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     1140

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     1200

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     1260

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     1320

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     1380

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     1440

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     1500

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     1560

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     1620

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     1680

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     1740

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     1800

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     1860

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     1920

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     1980

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     2040

acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt     2100

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2160

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt     2220

aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg     2280

cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca     2340

ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg     2400

ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc     2460

aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag     2520

gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt     2580

caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac     2640

aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa     2700

tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa     2760

caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc     2820

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     2880

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     2940

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     3000

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     3060

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     3120

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     3180

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     3240

gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg     3300

agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag     3360

aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa     3420

ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca     3480

aactatcggc cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat     3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcc     3600

actgaggccc agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3660

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3720

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact     3780

cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     3840

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     3900

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     3960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     4020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     4080

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     4140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     4200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     4260

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg     4320

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt     4380

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg     4440

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc     4500

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg     4560

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc     4620

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     4680

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     4740

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     4800

ggtgccccgc ggtgcggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     4860

gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc     4920

tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc     4980

ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc     5040

gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg     5100

tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg     5160

acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc     5220

tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct     5280

tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg     5340

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     5400

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     5460

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattgatta attcgagcga     5520

acgcgtcgag tcgctcggta cgatttaaat tgaattggcc tcgagcgcaa gcttgagcta     5580

gcgccaccat ggaatggatg agaagcagag tgggcaccct gggcctgtgg gtgcgactgc     5640

tgctggctgt gtttctgctg ggcgtgtacc aggcctaccc catccctgac tctagccccc     5700

tgctgcagtt tggcggacaa gtgcggcaga gatacctgta caccgacgac gaccaggaca     5760

ccgaggccca cctggaaatc cgcgaggatg gcacagtcgt gggcgctgct cacagaagcc     5820

ctgagagcct gctggaactg aaggccctga agcccggcgt gatccagatc ctgggcgtga     5880

aggccagcag attcctgtgc cagcagcctg acggcgccct gtacggctct cctcacttcg     5940

atcctgaggc ctgcagcttc agagagctgc tgctggagga cggctacaac gtgtaccagt     6000

ctgaggccca cggcctgccc ctgagactgc ctcagaagga cagccctaac caggacgcca     6060

caagctgggg acctgtgcgg ttcctgccta tgcctggact gctgcacgag ccccaggatc     6120

aggctggctt tctgcctcct gagcctccag acgtgggcag cagcgaccct ctgagcatgg     6180

tggaacctct gcagggcaga agccccagct acgcctcttg agaatgcggg cccggtaccc     6240

ccgacgcggc cgctaattct agatcgcgaa caaacaccat tgtcacactc cagtatacac     6300

aaacaccatt gtcacactcc agatatcaca aacaccattg tcacactcca aggcgaacaa     6360

acaccattgt cacactccaa ggctattcta gatcgcgaat tacatacttc tttacattcc     6420

agtatacatt acatacttct ttacattcca gatatcatta catacttctt tacattccaa     6480

ggcgaattac atacttcttt acattccaag gctacctgag gcccgggggt acctcttaat     6540

taactggcct catgggcctt ccgctcactg cccgctttcc agtcgggaaa cctgtcgtgc     6600

cagtcaggtg caggctgcct atcagaaggt ggtggctggt gtggccaatg ccctggctca     6660

caaataccac tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct     6720

tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     6780

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa     6840

tgagtatttg gtttagagtt tggcaacata tgcccatatg ctggctgcca tgaacaaagg     6900

ttggctataa agaggtcatc agtatatgaa acagccccct gctgtccatt ccttattcca     6960

tagaaaagcc ttgacttgag gttagatttt ttttatattt tgttttgtgt tatttttttc     7020

tttaacatcc ctaaaatttt ccttacatgt tttactagcc agatttttcc tcctctcctg     7080

actactccca gtcatagctg tccctcttct cttatggaga tccctcgacc tgcagcccaa     7140

gctgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     7200

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     7260

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctggcgtaa      7319


<210>  33
<211>  5678
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-null

<400>  33
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagac atggctcgac agatctgata tcatcgatga attcgagctc ggtacccggc      240

cgcagattta ggtgacacta tagaatatgc atcactagta agcttgcgaa ttccagtcta      300

cagagaggtc tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt      360

ttgctgtttg ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt      420

tcagtgtgga cttcagaggc agcacacaaa cagcaagctt gcgaattcca gtctacagag      480

aggtctctga cctctgcccc agctccaagg tcagcaggca gggagggctg tgtgtttgct      540

gtttgctgct tgcaatgttt gcccatttta gggacatgag taggctgaag tttgttcagt      600

gtggacttca gaggcagcac acaaacagca agcttgcgaa ttccagtcta cagagaggtc      660

tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt ttgctgtttg      720

ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt tcagtgtgga      780

cttcagaggc agcacacaaa cagcaagctt tgctctagac tggaattcgt cgacgagctc      840

cctatagtga gtcgtattag aggccgactg acccggtacc cggggatctt gctaccagtg      900

gaacagccac taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag      960

agactgtctg actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc     1020

caggtacaat gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg     1080

tccgggcagc gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc     1140

ctccgataac tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct     1200

ggatccactg cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac     1260

cactgacctg ggacagtgaa tgtccccctg atctgcggcc gtgactctct taaggtagcc     1320

ttgcagaagt tggtcgtgag gcactgggca ggtaagtatc aaggttacaa gacaggttta     1380

aggagaccaa tagaaactgg gcttgtcgag acagagaaga ctcttgcgtt tctgataggc     1440

acctattggt cttactgaca tccactttgc ctttctctcc acaggtgtcc actcccagtt     1500

caattacagc tcttaaggct agagtactta atacgactca ctataggcta gcctcgacct     1560

cgagacgcgt gatatcggat cccggccggc ggccgcttcc ctttagtgag ggttaatgct     1620

tcgagcagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg     1680

aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag     1740

ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga     1800

gatgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa tccgataagg     1860

gactagagca tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac     1920

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     1980

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     2040

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     2100

ctgaatggcg aatggaattc cagacgattg agcgtcaaaa tgtaggtatt tccatgagcg     2160

tttttccgtt gcaatggctg gcggtaatat tgttctggat attaccagca aggccgatag     2220

tttgagttct tctactcagg caagtgatgt tattactaat caaagaagta ttgcgacaac     2280

ggttaatttg cgtgatggac agactctttt actcggtggc ctcactgatt ataaaaacac     2340

ttctcaggat tctggcgtac cgttcctgtc taaaatccct ttaatcggcc tcctgtttag     2400

ctcccgctct gattctaacg aggaaagcac gttatacgtg ctcgtcaaag caaccatagt     2460

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     2520

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     2580

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     2640

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     2700

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     2760

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     2820

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     2880

acgcgaattt taacaaaata ttaacgtcta caatttaaat atttgcttat acaatcttcc     2940

tgtttttggg gcttttctga ttatcaaccg gggtacatat gattgacatg ctagttttac     3000

gattaccgtt catcgattct cttgtttgct ccagactctc aggcaatgac ctgatagcct     3060

ttgtagagac ctctcaaaaa tagctaccct ctccggcatg aatttatcag ctagaacggt     3120

tgaatatcat attgatggtg atttgactgt ctccggcctt tctcacccgt ttgaatcttt     3180

acctacacat tactcaggca ttgcatttaa aatatatgag ggttctaaaa atttttatcc     3240

ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag ggtcataatg tttttggtac     3300

aaccgattta gctttatgct ctgaggcttt attgcttaat tttgctaatt ctttgccttg     3360

cctgtatgat ttattggatg ttggaatcgc ctgatgcggt attttctcct tacgcatctg     3420

tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga tgccgcatag     3480

ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc     3540

ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt     3600

tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag     3660

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     3720

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     3780

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     3840

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     3900

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     3960

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     4020

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg     4080

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     4140

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     4200

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     4260

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     4320

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca     4380

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     4440

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     4500

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     4560

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     4620

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     4680

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     4740

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     4800

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     4860

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     4920

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     4980

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     5040

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     5100

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     5160

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     5220

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     5280

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     5340

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     5400

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     5460

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     5520

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     5580

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc     5640

aaaccgcctc tccccgcgcg ttggccgatt cattaatg                             5678


<210>  34
<211>  6363
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-moFGF21

<400>  34
cgcgtgatat cggatcccgg ccggcggccg cttcccttta gtgagggtta atgcttcgag       60

cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa      120

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      180

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggagatgt      240

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg taaaatccga taagggacta      300

gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta      360

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca      420

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgccag      480

ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa      540

tggcgaatgg aattccagac gattgagcgt caaaatgtag gtatttccat gagcgttttt      600

ccgttgcaat ggctggcggt aatattgttc tggatattac cagcaaggcc gatagtttga      660

gttcttctac tcaggcaagt gatgttatta ctaatcaaag aagtattgcg acaacggtta      720

atttgcgtga tggacagact cttttactcg gtggcctcac tgattataaa aacacttctc      780

aggattctgg cgtaccgttc ctgtctaaaa tccctttaat cggcctcctg tttagctccc      840

gctctgattc taacgaggaa agcacgttat acgtgctcgt caaagcaacc atagtacgcg      900

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca      960

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     1020

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     1080

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     1140

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     1200

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     1260

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     1320

aattttaaca aaatattaac gtctacaatt taaatatttg cttatacaat cttcctgttt     1380

ttggggcttt tctgattatc aaccggggta catatgattg acatgctagt tttacgatta     1440

ccgttcatcg attctcttgt ttgctccaga ctctcaggca atgacctgat agcctttgta     1500

gagacctctc aaaaatagct accctctccg gcatgaattt atcagctaga acggttgaat     1560

atcatattga tggtgatttg actgtctccg gcctttctca cccgtttgaa tctttaccta     1620

cacattactc aggcattgca tttaaaatat atgagggttc taaaaatttt tatccttgcg     1680

ttgaaataaa ggcttctccc gcaaaagtat tacagggtca taatgttttt ggtacaaccg     1740

atttagcttt atgctctgag gctttattgc ttaattttgc taattctttg ccttgcctgt     1800

atgatttatt ggatgttgga atcgcctgat gcggtatttt ctccttacgc atctgtgcgg     1860

tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag     1920

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     1980

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     2040

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     2100

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     2160

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     2220

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     2280

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     2340

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     2400

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     2460

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     2520

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     2580

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     2640

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     2700

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     2760

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     2820

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     2880

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     2940

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     3000

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     3060

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     3120

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     3180

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     3240

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     3300

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     3360

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     3420

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     3480

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     3540

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     3600

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     3660

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc     3720

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     3780

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     3840

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     3900

tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc     3960

tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg     4020

aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc     4080

gcctctcccc gcgcgttggc cgattcatta atgcagcagc tgcgcgctcg ctcgctcact     4140

gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc     4200

gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctt gtagttaatg     4260

attaacccgc catgctactt atctacgtag ccatgctcta gacatggctc gacagatctg     4320

atatcatcga tgaattcgag ctcggtaccc ggccgcagat ttaggtgaca ctatagaata     4380

tgcatcacta gtaagcttgc gaattccagt ctacagagag gtctctgacc tctgccccag     4440

ctccaaggtc agcaggcagg gagggctgtg tgtttgctgt ttgctgcttg caatgtttgc     4500

ccattttagg gacatgagta ggctgaagtt tgttcagtgt ggacttcaga ggcagcacac     4560

aaacagcaag cttgcgaatt ccagtctaca gagaggtctc tgacctctgc cccagctcca     4620

aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct gcttgcaatg tttgcccatt     4680

ttagggacat gagtaggctg aagtttgttc agtgtggact tcagaggcag cacacaaaca     4740

gcaagcttgc gaattccagt ctacagagag gtctctgacc tctgccccag ctccaaggtc     4800

agcaggcagg gagggctgtg tgtttgctgt ttgctgcttg caatgtttgc ccattttagg     4860

gacatgagta ggctgaagtt tgttcagtgt ggacttcaga ggcagcacac aaacagcaag     4920

ctttgctcta gactggaatt cgtcgacgag ctccctatag tgagtcgtat tagaggccga     4980

ctgacccggt acccggggat cttgctacca gtggaacagc cactaaggat tctgcagtga     5040

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     5100

caccttggac acaggacgct gtggtttctg agccaggtac aatgactcct ttcggtaagt     5160

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     5220

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     5280

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     5340

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt gaatgtcccc     5400

ctgatctgcg gccgtgactc tcttaaggta gccttgcaga agttggtcgt gaggcactgg     5460

gcaggtaagt atcaaggtta caagacaggt ttaaggagac caatagaaac tgggcttgtc     5520

gagacagaga agactcttgc gtttctgata ggcacctatt ggtcttactg acatccactt     5580

tgcctttctc tccacaggtg tccactccca gttcaattac agctcttaag gctagagtac     5640

ttaatacgac tcactatagg ctagcctcga cctcgagcgc aagcttgagc tagcgccacc     5700

atggaatgga tgagaagcag agtgggcacc ctgggcctgt gggtgcgact gctgctggct     5760

gtgtttctgc tgggcgtgta ccaggcctac cccatccctg actctagccc cctgctgcag     5820

tttggcggac aagtgcggca gagatacctg tacaccgacg acgaccagga caccgaggcc     5880

cacctggaaa tccgcgagga tggcacagtc gtgggcgctg ctcacagaag ccctgagagc     5940

ctgctggaac tgaaggccct gaagcccggc gtgatccaga tcctgggcgt gaaggccagc     6000

agattcctgt gccagcagcc tgacggcgcc ctgtacggct ctcctcactt cgatcctgag     6060

gcctgcagct tcagagagct gctgctggag gacggctaca acgtgtacca gtctgaggcc     6120

cacggcctgc ccctgagact gcctcagaag gacagcccta accaggacgc cacaagctgg     6180

ggacctgtgc ggttcctgcc tatgcctgga ctgctgcacg agccccagga tcaggctggc     6240

tttctgcctc ctgagcctcc agacgtgggc agcagcgacc ctctgagcat ggtggaacct     6300

ctgcagggca gaagccccag ctacgcctct tgagaatgcg ggcccggtac ccccgacgcg     6360

gcc                                                                   6363


<210>  35
<211>  4403
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CMV-null

<400>  35
cgacggtacc agcgctgtcg aggccgcttc gagcagacat gataagatac attgatgagt       60

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg      120

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca      180

ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc      240

tctacaaatg tggtaaaatc gattaggatc ttcctagagc atggctacct agacatggct      300

cgacagatca gcgctcatgc tctggaagat ctcgatttaa atgcggccgc aggaacccct      360

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc      420

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag      480

ctgcctgcag gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca      540

ccgcatacgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt      600

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc      660

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg      720

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat      780

ttgggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg      840

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct      900

atctcgggct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa      960

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt     1020

ttatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac     1080

ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga     1140

caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa     1200

cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     1260

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     1320

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     1380

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     1440

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     1500

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     1560

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     1620

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     1680

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     1740

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     1800

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     1860

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     1920

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     1980

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     2040

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     2100

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     2160

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     2220

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     2280

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     2340

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     2400

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     2460

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     2520

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     2580

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     2640

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     2700

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     2760

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     2820

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     2880

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     2940

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     3000

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     3060

gccttttgct ggccttttgc tcacatgtcc tgcaggcagc tgcgcgctcg ctcgctcact     3120

gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc     3180

gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg cggccgcgat     3240

atctgtagtt aatgattaac ccgccatgct acttatctac agatctcaat attggccatt     3300

agccatatta ttcattggtt atatagcata aatcaatatt ggctattggc cattgcatac     3360

gttgtatcta tatcataata tgtacattta tattggctca tgtccaatat gaccgccatg     3420

ttggcattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag     3480

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc     3540

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg     3600

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca     3660

tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc     3720

ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt     3780

attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg ggcgtggata     3840

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt     3900

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactgcgatc gcccgccccg     3960

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta     4020

gtgaaccgtc agatcactag gctagctatt gcggtagttt atcacagtta aattgctaac     4080

gcagtcagtg cttctgacac aacagtctcg aacttaagct gcagtgactc tcttaaggta     4140

gccttgcaga agttggtcgt gaggcactgg gcaggtaagt atcaaggtta caagacaggt     4200

ttaaggagac caatagaaac tgggcttgtc gagacagaga agactcttgc gtttctgata     4260

ggcacctatt ggtcttactg acatccactt tgcctttctc tccacaggtg tccactccca     4320

gttcaattac agctcttaag gctagagtac ttaatacgac tcactataga atacgactca     4380

ctatagggag acgctagcgt cga                                             4403


<210>  36
<211>  5073
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CMV-moFGF21

<400>  36
ggggctagcg ccaccatgga atggatgaga agcagagtgg gcaccctggg cctgtgggtg       60

cgactgctgc tggctgtgtt tctgctgggc gtgtaccagg cctaccccat ccctgactct      120

agccccctgc tgcagtttgg cggacaagtg cggcagagat acctgtacac cgacgacgac      180

caggacaccg aggcccacct ggaaatccgc gaggatggca cagtcgtggg cgctgctcac      240

agaagccctg agagcctgct ggaactgaag gccctgaagc ccggcgtgat ccagatcctg      300

ggcgtgaagg ccagcagatt cctgtgccag cagcctgacg gcgccctgta cggctctcct      360

cacttcgatc ctgaggcctg cagcttcaga gagctgctgc tggaggacgg ctacaacgtg      420

taccagtctg aggcccacgg cctgcccctg agactgcctc agaaggacag ccctaaccag      480

gacgccacaa gctggggacc tgtgcggttc ctgcctatgc ctggactgct gcacgagccc      540

caggatcagg ctggctttct gcctcctgag cctccagacg tgggcagcag cgaccctctg      600

agcatggtgg aacctctgca gggcagaagc cccagctacg cctcttgaga atgcgggccc      660

ggtaccccct cgacggtacc agcgctgtcg aggccgcttc gagcagacat gataagatac      720

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa      780

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac      840

aacaattgca ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc      900

aagtaaaacc tctacaaatg tggtaaaatc gattaggatc ttcctagagc atggctacct      960

agacatggct cgacagatca gcgctcatgc tctggaagat ctcgatttaa atgcggccgc     1020

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     1080

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     1140

gagcgcgcag ctgcctgcag gggcgcctga tgcggtattt tctccttacg catctgtgcg     1200

gtatttcaca ccgcatacgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag     1260

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     1320

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     1380

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     1440

aaaacttgat ttgggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     1500

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     1560

actcaaccct atctcgggct attcttttga tttataaggg attttgccga tttcggccta     1620

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac     1680

gtttacaatt ttatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca     1740

gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc     1800

cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc     1860

atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt     1920

catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac     1980

ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc     2040

ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt     2100

cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct     2160

ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga     2220

tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag     2280

cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca     2340

actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga     2400

aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag     2460

tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc     2520

ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa     2580

tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt     2640

gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg     2700

gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt     2760

tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg     2820

gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat     2880

ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact     2940

gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa     3000

aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt     3060

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt     3120

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg     3180

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca     3240

gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt     3300

agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga     3360

taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc     3420

gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact     3480

gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga     3540

caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg     3600

aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt     3660

tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt     3720

acggttcctg gccttttgct ggccttttgc tcacatgtcc tgcaggcagc tgcgcgctcg     3780

ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc     3840

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg     3900

cggccgcgat atctgtagtt aatgattaac ccgccatgct acttatctac agatctcaat     3960

attggccatt agccatatta ttcattggtt atatagcata aatcaatatt ggctattggc     4020

cattgcatac gttgtatcta tatcataata tgtacattta tattggctca tgtccaatat     4080

gaccgccatg ttggcattga ttattgacta gttattaata gtaatcaatt acggggtcat     4140

tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg     4200

gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa     4260

cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact     4320

tggcagtaca tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta     4380

aatggcccgc ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt     4440

acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg     4500

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg     4560

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactgcgatc     4620

gcccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag     4680

agctcgttta gtgaaccgtc agatcactag gctagctatt gcggtagttt atcacagtta     4740

aattgctaac gcagtcagtg cttctgacac aacagtctcg aacttaagct gcagtgactc     4800

tcttaaggta gccttgcaga agttggtcgt gaggcactgg gcaggtaagt atcaaggtta     4860

caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga agactcttgc     4920

gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc tccacaggtg     4980

tccactccca gttcaattac agctcttaag gctagagtac ttaatacgac tcactataga     5040

atacgactca ctatagggag acgctagcgt cga                                  5073


<210>  37
<211>  7292
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-cloFGF21-dmiRT

<400>  37
ggccgctaat tctagatcgc gaacaaacac cattgtcaca ctccagtata cacaaacacc       60

attgtcacac tccagatatc acaaacacca ttgtcacact ccaaggcgaa caaacaccat      120

tgtcacactc caaggctatt ctagatcgcg aattacatac ttctttacat tccagtatac      180

attacatact tctttacatt ccagatatca ttacatactt ctttacattc caaggcgaat      240

tacatacttc tttacattcc aaggctacct gaggcccggg ggtacctctt aattaactgg      300

cctcatgggc cttccgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagtcag      360

gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca atgccctggc tcacaaatac      420

cactgagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat      480

ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg      540

tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat      600

ttggtttaga gtttggcaac atatgcccat atgctggctg ccatgaacaa aggttggcta      660

taaagaggtc atcagtatat gaaacagccc cctgctgtcc attccttatt ccatagaaaa      720

gccttgactt gaggttagat tttttttata ttttgttttg tgttattttt ttctttaaca      780

tccctaaaat tttccttaca tgttttacta gccagatttt tcctcctctc ctgactactc      840

ccagtcatag ctgtccctct tctcttatgg agatccctcg acctgcagcc caagctgtag      900

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca      960

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     1020

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctggcgt aaagtgagcg     1080

agcgagcgcg cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     1140

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     1200

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     1260

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     1320

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     1380

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     1440

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     1500

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     1560

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     1620

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     1680

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     1740

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     1800

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     1860

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     1920

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     1980

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     2040

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     2100

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     2160

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     2220

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     2280

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     2340

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     2400

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     2460

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     2520

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     2580

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     2640

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     2700

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     2760

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     2820

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     2880

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     2940

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     3000

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     3060

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa     3120

aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct     3180

ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag     3240

acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc ttaactatgc     3300

ggcatcagag cagattgtac tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg     3360

cgtaaggaga aaataccgca tcaggcgatt ccaacatcca ataaatcata caggcaaggc     3420

aaagaattag caaaattaag caataaagcc tcagagcata aagctaaatc ggttgtacca     3480

aaaacattat gaccctgtaa tacttttgcg ggagaagcct ttatttcaac gcaaggataa     3540

aaatttttag aaccctcata tattttaaat gcaatgcctg agtaatgtgt aggtaaagat     3600

tcaaacgggt gagaaaggcc ggagacagtc aaatcaccat caatatgata ttcaaccgtt     3660

ctagctgata aattcatgcc ggagagggta gctatttttg agaggtctct acaaaggcta     3720

tcaggtcatt gcctgagagt ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa     3780

ctagcatgtc aatcatatgt accccggttg ataatcagaa aagccccaaa aacaggaaga     3840

ttgtataagc aaatatttaa attgtaagcg ttaatatttt gttaaaattc gcgttaaatt     3900

tttgttaaat cagctcattt tttaaccaat aggccgaaat cggcaaaatc ccttataaat     3960

caaaagaata gaccgagata gggttgagtg ttgttccagt ttggaacaag agtccactat     4020

taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac     4080

tacgtgaacc atcaccctaa tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc     4140

ggaaccctaa agggagcccc cgatttagag cttgacgggg aaagccggcg aacgtggcga     4200

gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc gctggcaagt gtagcggtca     4260

cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg     4320

gttgctttga cgagcacgta taacgtgctt tcctcgttag aatcagagcg ggagctaaac     4380

aggaggccga ttaaagggat tttagacagg aacggtacgc cagaatcctg agaagtgttt     4440

ttataatcag tgaggccacc gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc     4500

gcaatacttc tttgattagt aataacatca cttgcctgag tagaagaact caaactatcg     4560

gccttgctgg taatatccag aacaatatta ccgccagcca ttgcaacgga atcgccattc     4620

gccattcagg ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt ccactgaggc     4680

ccagctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc gtcgggcgac     4740

ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg ccaactccat     4800

cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta ctcgacattg     4860

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat     4920

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc     4980

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca     5040

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta     5100

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta     5160

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat     5220

cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca tctccccccc     5280

ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag cgatgggggc     5340

gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc     5400

gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt ttccttttat     5460

ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg cgggagtcgc     5520

tgcgttgcct tcgccccgtg ccccgctccg cgccgcctcg cgccgcccgc cccggctctg     5580

actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa     5640

ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg     5700

gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg tgtgtgtgtg     5760

cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct gcgggcgcgg     5820

cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg gcggtgcccc     5880

gcggtgcggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt     5940

gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag     6000

ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg     6060

ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg     6120

ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg     6180

cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt     6240

tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc     6300

gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     6360

cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct     6420

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta     6480

gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc     6540

tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtcg     6600

agtcgctcgg tacgatttaa attgaattgg cctcgagcgc aagcttgagc tagcgccacc     6660

atgggatggg ctgaggctgg attcgaacac ctgggactct gggtgcccgt cctggccgtg     6720

ctgctcctgg aggcttgcag ggctcatccc atccctgaca gctccccact cctgcagttt     6780

ggaggacagg tgaggcagcg gtacctgtat accgacgatg cccaggagac agaagctcac     6840

ctggaaattc gggctgatgg aacagtggtc ggagctgccc gacagtcccc agagtctctc     6900

ctggaactga aggccctcaa acccggagtg atccagattc tgggcgtcaa gacttctaga     6960

ttcctgtgcc agggaccaga cggcaccctg tacggcagcc tgcatttcga tcctgtggcc     7020

tgttcctttc gagagctcct gctcgaagac ggctacaaca tctatcactc tgagaccctg     7080

ggactcccac tgcgactcag acctcataat agtgcctatc gagatctggc tcccaggggc     7140

ccagctaggt ttctgccact ccccggactg ctccctgctc cacctgagcc acccggcatt     7200

ctggctccag aacctccaga cgtgggctct agtgatccac tgagtatggt cggcccctca     7260

caggggaggt cacctagcta cgccagctga gc                                   7292


<210>  38
<211>  6278
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-cloFGF21

<400>  38
ggccgcttcc ctttagtgag ggttaatgct tcgagcagac atgataagat acattgatga       60

gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga      120

tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg      180

cattcatttt atgtttcagg ttcaggggga gatgtgggag gttttttaaa gcaagtaaaa      240

cctctacaaa tgtggtaaaa tccgataagg gactagagca tggctacgta gataagtagc      300

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc      360

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg      420

cccgggcggc ctcagtgagc gagcgagcgc gccagctggc gtaatagcga agaggcccgc      480

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggaattc cagacgattg      540

agcgtcaaaa tgtaggtatt tccatgagcg tttttccgtt gcaatggctg gcggtaatat      600

tgttctggat attaccagca aggccgatag tttgagttct tctactcagg caagtgatgt      660

tattactaat caaagaagta ttgcgacaac ggttaatttg cgtgatggac agactctttt      720

actcggtggc ctcactgatt ataaaaacac ttctcaggat tctggcgtac cgttcctgtc      780

taaaatccct ttaatcggcc tcctgtttag ctcccgctct gattctaacg aggaaagcac      840

gttatacgtg ctcgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg      900

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc      960

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     1020

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     1080

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     1140

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     1200

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     1260

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgtcta     1320

caatttaaat atttgcttat acaatcttcc tgtttttggg gcttttctga ttatcaaccg     1380

gggtacatat gattgacatg ctagttttac gattaccgtt catcgattct cttgtttgct     1440

ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct     1500

ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt     1560

ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa     1620

aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa     1680

agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt     1740

attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaatcgc     1800

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact     1860

ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc     1920

gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc     1980

gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga     2040

aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag     2100

acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     2160

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     2220

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     2280

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     2340

gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt     2400

gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt     2460

ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat     2520

tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg     2580

acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta     2640

cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat     2700

catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag     2760

cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa     2820

ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca     2880

ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc     2940

ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt     3000

atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc     3060

gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat     3120

atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt     3180

tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac     3240

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc     3300

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca     3360

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta     3420

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct     3480

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg     3540

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc     3600

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta     3660

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg     3720

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt     3780

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg     3840

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg     3900

ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc     3960

gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg     4020

agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt     4080

cattaatgca gcagctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc     4140

gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg     4200

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta     4260

cgtagccatg ctctagacat ggctcgacag atctgatatc atcgatgaat tcgagctcgg     4320

tacccggccg cagatttagg tgacactata gaatatgcat cactagtaag cttgcgaatt     4380

ccagtctaca gagaggtctc tgacctctgc cccagctcca aggtcagcag gcagggaggg     4440

ctgtgtgttt gctgtttgct gcttgcaatg tttgcccatt ttagggacat gagtaggctg     4500

aagtttgttc agtgtggact tcagaggcag cacacaaaca gcaagcttgc gaattccagt     4560

ctacagagag gtctctgacc tctgccccag ctccaaggtc agcaggcagg gagggctgtg     4620

tgtttgctgt ttgctgcttg caatgtttgc ccattttagg gacatgagta ggctgaagtt     4680

tgttcagtgt ggacttcaga ggcagcacac aaacagcaag cttgcgaatt ccagtctaca     4740

gagaggtctc tgacctctgc cccagctcca aggtcagcag gcagggaggg ctgtgtgttt     4800

gctgtttgct gcttgcaatg tttgcccatt ttagggacat gagtaggctg aagtttgttc     4860

agtgtggact tcagaggcag cacacaaaca gcaagctttg ctctagactg gaattcgtcg     4920

acgagctccc tatagtgagt cgtattagag gccgactgac ccggtacccg gggatcttgc     4980

taccagtgga acagccacta aggattctgc agtgagagca gagggccagc taagtggtac     5040

tctcccagag actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt     5100

ttctgagcca ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag     5160

gcaaagcgtc cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct     5220

gtttgctcct ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt     5280

gcccctctgg atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca     5340

ggcaccacca ctgacctggg acagtgaatg tccccctgat ctgcggccgt gactctctta     5400

aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa ggttacaaga     5460

caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact cttgcgtttc     5520

tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac aggtgtccac     5580

tcccagttca attacagctc ttaaggctag agtacttaat acgactcact ataggctagc     5640

gccaccatgg gatgggctga ggctggattc gaacacctgg gactctgggt gcccgtcctg     5700

gccgtgctgc tcctggaggc ttgcagggct catcccatcc ctgacagctc cccactcctg     5760

cagtttggag gacaggtgag gcagcggtac ctgtataccg acgatgccca ggagacagaa     5820

gctcacctgg aaattcgggc tgatggaaca gtggtcggag ctgcccgaca gtccccagag     5880

tctctcctgg aactgaaggc cctcaaaccc ggagtgatcc agattctggg cgtcaagact     5940

tctagattcc tgtgccaggg accagacggc accctgtacg gcagcctgca tttcgatcct     6000

gtggcctgtt cctttcgaga gctcctgctc gaagacggct acaacatcta tcactctgag     6060

accctgggac tcccactgcg actcagacct cataatagtg cctatcgaga tctggctccc     6120

aggggcccag ctaggtttct gccactcccc ggactgctcc ctgctccacc tgagccaccc     6180

ggcattctgg ctccagaacc tccagacgtg ggctctagtg atccactgag tatggtcggc     6240

ccctcacagg ggaggtcacc tagctacgcc agctgagc                             6278


<210>  39
<211>  6278
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-hsFGF21

<400>  39
gatctgatat catcgatgaa ttcgagctcg gtacccggcc gcagatttag gtgacactat       60

agaatatgca tcactagtaa gcttgcgaat tccagtctac agagaggtct ctgacctctg      120

ccccagctcc aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat      180

gtttgcccat tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca      240

gcacacaaac agcaagcttg cgaattccag tctacagaga ggtctctgac ctctgcccca      300

gctccaaggt cagcaggcag ggagggctgt gtgtttgctg tttgctgctt gcaatgtttg      360

cccattttag ggacatgagt aggctgaagt ttgttcagtg tggacttcag aggcagcaca      420

caaacagcaa gcttgcgaat tccagtctac agagaggtct ctgacctctg ccccagctcc      480

aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat gtttgcccat      540

tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca gcacacaaac      600

agcaagcttt gctctagact ggaattcgtc gacgagctcc ctatagtgag tcgtattaga      660

ggccgactga cccggtaccc ggggatcttg ctaccagtgg aacagccact aaggattctg      720

cagtgagagc agagggccag ctaagtggta ctctcccaga gactgtctga ctcacgccac      780

cccctccacc ttggacacag gacgctgtgg tttctgagcc aggtacaatg actcctttcg      840

gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg taggcgggcg      900

actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact ggggtgacct      960

tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc ttaaatacgg     1020

acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg gacagtgaat     1080

gtccccctga tctgcggccg tgactctctt aaggtagcct tgcagaagtt ggtcgtgagg     1140

cactgggcag gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg     1200

cttgtcgaga cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat     1260

ccactttgcc tttctctcca caggtgtcca ctcccagttc aattacagct cttaaggcta     1320

gagtacttaa tacgactcac tataggctag cgccaccatg gactcggacg agaccgggtt     1380

cgagcactca ggactgtggg tttctgtgct ggctggtctt ctgctgggag cctgccaggc     1440

acaccccatc cctgactcca gtcctctcct gcaattcggg ggccaagtcc ggcagcggta     1500

cctctacaca gatgatgccc agcagacaga agcccacctg gagatcaggg aggatgggac     1560

ggtggggggc gctgctgacc agagccccga aagtctcctg cagctgaaag ccttgaagcc     1620

gggagttatt caaatcttgg gagtcaagac atccaggttc ctgtgccagc ggccagatgg     1680

ggccctgtat ggatcgctcc actttgaccc tgaggcctgc agcttccggg agctgcttct     1740

tgaggacgga tacaatgttt accagtccga agcccacggc ctcccgctgc acctgccagg     1800

gaacaagtcc ccacaccggg accctgcacc ccgaggacca gctcgcttcc tgccactacc     1860

aggcctgccc cccgcactcc cggagccacc cggaatcctg gccccccagc cccccgatgt     1920

gggctcctcg gaccctctga gcatggtggg accttcccag ggccgaagcc ccagctacgc     1980

ttcctgagcg gccgcttccc tttagtgagg gttaatgctt cgagcagaca tgataagata     2040

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga     2100

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     2160

caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg ttttttaaag     2220

caagtaaaac ctctacaaat gtggtaaaat ccgataaggg actagagcat ggctacgtag     2280

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca     2340

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     2400

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg ccagctggcg taatagcgaa     2460

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggaattcc     2520

agacgattga gcgtcaaaat gtaggtattt ccatgagcgt ttttccgttg caatggctgg     2580

cggtaatatt gttctggata ttaccagcaa ggccgatagt ttgagttctt ctactcaggc     2640

aagtgatgtt attactaatc aaagaagtat tgcgacaacg gttaatttgc gtgatggaca     2700

gactctttta ctcggtggcc tcactgatta taaaaacact tctcaggatt ctggcgtacc     2760

gttcctgtct aaaatccctt taatcggcct cctgtttagc tcccgctctg attctaacga     2820

ggaaagcacg ttatacgtgc tcgtcaaagc aaccatagta cgcgccctgt agcggcgcat     2880

taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag     2940

cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc     3000

aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc     3060

ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt     3120

ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa     3180

caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg     3240

cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat     3300

taacgtctac aatttaaata tttgcttata caatcttcct gtttttgggg cttttctgat     3360

tatcaaccgg ggtacatatg attgacatgc tagttttacg attaccgttc atcgattctc     3420

ttgtttgctc cagactctca ggcaatgacc tgatagcctt tgtagagacc tctcaaaaat     3480

agctaccctc tccggcatga atttatcagc tagaacggtt gaatatcata ttgatggtga     3540

tttgactgtc tccggccttt ctcacccgtt tgaatcttta cctacacatt actcaggcat     3600

tgcatttaaa atatatgagg gttctaaaaa tttttatcct tgcgttgaaa taaaggcttc     3660

tcccgcaaaa gtattacagg gtcataatgt ttttggtaca accgatttag ctttatgctc     3720

tgaggcttta ttgcttaatt ttgctaattc tttgccttgc ctgtatgatt tattggatgt     3780

tggaatcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata     3840

tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg     3900

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     3960

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     4020

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     4080

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     4140

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     4200

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     4260

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     4320

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     4380

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     4440

ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc     4500

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     4560

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     4620

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     4680

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     4740

aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta     4800

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     4860

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     4920

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     4980

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     5040

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     5100

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     5160

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     5220

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     5280

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     5340

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     5400

gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     5460

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     5520

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     5580

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     5640

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     5700

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     5760

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     5820

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     5880

ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac     5940

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc     6000

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt     6060

tggccgattc attaatgcag cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa     6120

agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag     6180

agggagtggc caactccatc actaggggtt ccttgtagtt aatgattaac ccgccatgct     6240

acttatctac gtagccatgc tctagacatg gctcgaca                             6278


<210>  40
<211>  6278
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-hsoFGF21 variant 1

<400>  40
gatctgatat catcgatgaa ttcgagctcg gtacccggcc gcagatttag gtgacactat       60

agaatatgca tcactagtaa gcttgcgaat tccagtctac agagaggtct ctgacctctg      120

ccccagctcc aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat      180

gtttgcccat tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca      240

gcacacaaac agcaagcttg cgaattccag tctacagaga ggtctctgac ctctgcccca      300

gctccaaggt cagcaggcag ggagggctgt gtgtttgctg tttgctgctt gcaatgtttg      360

cccattttag ggacatgagt aggctgaagt ttgttcagtg tggacttcag aggcagcaca      420

caaacagcaa gcttgcgaat tccagtctac agagaggtct ctgacctctg ccccagctcc      480

aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat gtttgcccat      540

tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca gcacacaaac      600

agcaagcttt gctctagact ggaattcgtc gacgagctcc ctatagtgag tcgtattaga      660

ggccgactga cccggtaccc ggggatcttg ctaccagtgg aacagccact aaggattctg      720

cagtgagagc agagggccag ctaagtggta ctctcccaga gactgtctga ctcacgccac      780

cccctccacc ttggacacag gacgctgtgg tttctgagcc aggtacaatg actcctttcg      840

gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg taggcgggcg      900

actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact ggggtgacct      960

tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc ttaaatacgg     1020

acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg gacagtgaat     1080

gtccccctga tctgcggccg tgactctctt aaggtagcct tgcagaagtt ggtcgtgagg     1140

cactgggcag gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg     1200

cttgtcgaga cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat     1260

ccactttgcc tttctctcca caggtgtcca ctcccagttc aattacagct cttaaggcta     1320

gagtacttaa tacgactcac tataggctag cgccaccatg gattctgatg agacaggctt     1380

cgagcacagc ggcctgtggg tttcagttct ggctggactg ctgctgggag cctgtcaggc     1440

acaccctatt ccagatagca gccctctgct gcagttcggc ggacaagtgc ggcagagata     1500

cctgtacacc gacgacgccc agcagacaga agcccacctg gaaatcagag aggatggcac     1560

agttggcgga gccgccgatc agtctcctga atctctgctc cagctgaagg ccctgaagcc     1620

tggcgtgatc cagatcctgg gcgtgaaaac cagccggttc ctgtgccaaa gacctgacgg     1680

cgccctgtat ggcagcctgc actttgatcc tgaggcctgc agcttcagag agctgctgct     1740

tgaggacggc tacaacgtgt accagtctga ggcccatggc ctgcctctgc atctgcctgg     1800

aaacaagagc cctcacagag atcccgctcc tagaggccct gccagatttc tgcctcttcc     1860

tggattgcct cctgctctgc cagagcctcc tggaattctg gctcctcagc ctcctgatgt     1920

gggcagctct gatcctctga gcatggtcgg acctagccag ggcagatctc ctagctacgc     1980

ctcttgagcg gccgcttccc tttagtgagg gttaatgctt cgagcagaca tgataagata     2040

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga     2100

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     2160

caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg ttttttaaag     2220

caagtaaaac ctctacaaat gtggtaaaat ccgataaggg actagagcat ggctacgtag     2280

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca     2340

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     2400

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg ccagctggcg taatagcgaa     2460

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggaattcc     2520

agacgattga gcgtcaaaat gtaggtattt ccatgagcgt ttttccgttg caatggctgg     2580

cggtaatatt gttctggata ttaccagcaa ggccgatagt ttgagttctt ctactcaggc     2640

aagtgatgtt attactaatc aaagaagtat tgcgacaacg gttaatttgc gtgatggaca     2700

gactctttta ctcggtggcc tcactgatta taaaaacact tctcaggatt ctggcgtacc     2760

gttcctgtct aaaatccctt taatcggcct cctgtttagc tcccgctctg attctaacga     2820

ggaaagcacg ttatacgtgc tcgtcaaagc aaccatagta cgcgccctgt agcggcgcat     2880

taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag     2940

cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc     3000

aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc     3060

ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt     3120

ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa     3180

caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg     3240

cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat     3300

taacgtctac aatttaaata tttgcttata caatcttcct gtttttgggg cttttctgat     3360

tatcaaccgg ggtacatatg attgacatgc tagttttacg attaccgttc atcgattctc     3420

ttgtttgctc cagactctca ggcaatgacc tgatagcctt tgtagagacc tctcaaaaat     3480

agctaccctc tccggcatga atttatcagc tagaacggtt gaatatcata ttgatggtga     3540

tttgactgtc tccggccttt ctcacccgtt tgaatcttta cctacacatt actcaggcat     3600

tgcatttaaa atatatgagg gttctaaaaa tttttatcct tgcgttgaaa taaaggcttc     3660

tcccgcaaaa gtattacagg gtcataatgt ttttggtaca accgatttag ctttatgctc     3720

tgaggcttta ttgcttaatt ttgctaattc tttgccttgc ctgtatgatt tattggatgt     3780

tggaatcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata     3840

tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg     3900

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     3960

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     4020

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     4080

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     4140

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     4200

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     4260

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     4320

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     4380

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     4440

ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc     4500

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     4560

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     4620

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     4680

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     4740

aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta     4800

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     4860

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     4920

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     4980

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     5040

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     5100

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     5160

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     5220

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     5280

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     5340

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     5400

gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     5460

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     5520

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     5580

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     5640

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     5700

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     5760

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     5820

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     5880

ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac     5940

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc     6000

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt     6060

tggccgattc attaatgcag cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa     6120

agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag     6180

agggagtggc caactccatc actaggggtt ccttgtagtt aatgattaac ccgccatgct     6240

acttatctac gtagccatgc tctagacatg gctcgaca                             6278


<210>  41
<211>  6278
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-hsoFGF21 variant 2

<400>  41
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagac atggctcgac agatctgata tcatcgatga attcgagctc ggtacccggc      240

cgcagattta ggtgacacta tagaatatgc atcactagta agcttgcgaa ttccagtcta      300

cagagaggtc tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt      360

ttgctgtttg ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt      420

tcagtgtgga cttcagaggc agcacacaaa cagcaagctt gcgaattcca gtctacagag      480

aggtctctga cctctgcccc agctccaagg tcagcaggca gggagggctg tgtgtttgct      540

gtttgctgct tgcaatgttt gcccatttta gggacatgag taggctgaag tttgttcagt      600

gtggacttca gaggcagcac acaaacagca agcttgcgaa ttccagtcta cagagaggtc      660

tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt ttgctgtttg      720

ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt tcagtgtgga      780

cttcagaggc agcacacaaa cagcaagctt tgctctagac tggaattcgt cgacgagctc      840

cctatagtga gtcgtattag aggccgactg acccggtacc cggggatctt gctaccagtg      900

gaacagccac taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag      960

agactgtctg actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc     1020

caggtacaat gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg     1080

tccgggcagc gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc     1140

ctccgataac tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct     1200

ggatccactg cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac     1260

cactgacctg ggacagtgaa tgtccccctg atctgcggcc gtgactctct taaggtagcc     1320

ttgcagaagt tggtcgtgag gcactgggca ggtaagtatc aaggttacaa gacaggttta     1380

aggagaccaa tagaaactgg gcttgtcgag acagagaaga ctcttgcgtt tctgataggc     1440

acctattggt cttactgaca tccactttgc ctttctctcc acaggtgtcc actcccagtt     1500

caattacagc tcttaaggct agagtactta atacgactca ctataggcta gcgccaccat     1560

ggacagcgat gaaaccgggt tcgagcacag cggtctgtgg gtgtccgtgc tggccggact     1620

gctcctggga gcctgtcagg cgcaccccat ccctgactcc tcgccgctgc tgcaattcgg     1680

cggacaagtc cgccagagat acctgtacac cgacgacgcc cagcagaccg aagcccacct     1740

ggaaattcgg gaggacggga ctgtgggagg cgctgcagat cagtcacccg agtccctcct     1800

ccaactgaag gccttgaagc ccggcgtgat tcagatcctg ggcgtgaaaa cttcccgctt     1860

cctttgccaa cggccggatg gagctctgta cggatccctg cacttcgacc ccgaagcctg     1920

ctcattccgc gagctgctcc ttgaggacgg ctataacgtg taccagtctg aggcccatgg     1980

actccccctg catctgcccg gcaacaagtc ccctcaccgg gatcctgccc caagaggccc     2040

agctcggttt ctgcctctgc cgggactgcc tccagcgttg cccgaacccc ctggtatcct     2100

ggccccgcaa ccacctgacg tcggttcgtc ggacccgctg agcatggtcg gtccgagcca     2160

gggaaggtcc ccgtcctacg catcctgagc ggccgcttcc ctttagtgag ggttaatgct     2220

tcgagcagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg     2280

aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag     2340

ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga     2400

gatgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa tccgataagg     2460

gactagagca tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac     2520

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     2580

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     2640

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     2700

ctgaatggcg aatggaattc cagacgattg agcgtcaaaa tgtaggtatt tccatgagcg     2760

tttttccgtt gcaatggctg gcggtaatat tgttctggat attaccagca aggccgatag     2820

tttgagttct tctactcagg caagtgatgt tattactaat caaagaagta ttgcgacaac     2880

ggttaatttg cgtgatggac agactctttt actcggtggc ctcactgatt ataaaaacac     2940

ttctcaggat tctggcgtac cgttcctgtc taaaatccct ttaatcggcc tcctgtttag     3000

ctcccgctct gattctaacg aggaaagcac gttatacgtg ctcgtcaaag caaccatagt     3060

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     3120

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     3180

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     3240

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     3300

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     3360

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     3420

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     3480

acgcgaattt taacaaaata ttaacgtcta caatttaaat atttgcttat acaatcttcc     3540

tgtttttggg gcttttctga ttatcaaccg gggtacatat gattgacatg ctagttttac     3600

gattaccgtt catcgattct cttgtttgct ccagactctc aggcaatgac ctgatagcct     3660

ttgtagagac ctctcaaaaa tagctaccct ctccggcatg aatttatcag ctagaacggt     3720

tgaatatcat attgatggtg atttgactgt ctccggcctt tctcacccgt ttgaatcttt     3780

acctacacat tactcaggca ttgcatttaa aatatatgag ggttctaaaa atttttatcc     3840

ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag ggtcataatg tttttggtac     3900

aaccgattta gctttatgct ctgaggcttt attgcttaat tttgctaatt ctttgccttg     3960

cctgtatgat ttattggatg ttggaatcgc ctgatgcggt attttctcct tacgcatctg     4020

tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga tgccgcatag     4080

ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc     4140

ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt     4200

tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag     4260

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     4320

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     4380

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     4440

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     4500

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     4560

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     4620

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg     4680

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     4740

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     4800

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     4860

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     4920

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca     4980

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     5040

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     5100

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     5160

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     5220

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     5280

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     5340

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     5400

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     5460

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     5520

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     5580

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     5640

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     5700

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     5760

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     5820

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     5880

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     5940

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     6000

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     6060

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     6120

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     6180

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc     6240

aaaccgcctc tccccgcgcg ttggccgatt cattaatg                             6278


<210>  42
<211>  6278
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pGG2-hAAT-hsoFGF21 variant 3

<400>  42
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagac atggctcgac agatctgata tcatcgatga attcgagctc ggtacccggc      240

cgcagattta ggtgacacta tagaatatgc atcactagta agcttgcgaa ttccagtcta      300

cagagaggtc tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt      360

ttgctgtttg ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt      420

tcagtgtgga cttcagaggc agcacacaaa cagcaagctt gcgaattcca gtctacagag      480

aggtctctga cctctgcccc agctccaagg tcagcaggca gggagggctg tgtgtttgct      540

gtttgctgct tgcaatgttt gcccatttta gggacatgag taggctgaag tttgttcagt      600

gtggacttca gaggcagcac acaaacagca agcttgcgaa ttccagtcta cagagaggtc      660

tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt ttgctgtttg      720

ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt tcagtgtgga      780

cttcagaggc agcacacaaa cagcaagctt tgctctagac tggaattcgt cgacgagctc      840

cctatagtga gtcgtattag aggccgactg acccggtacc cggggatctt gctaccagtg      900

gaacagccac taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag      960

agactgtctg actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc     1020

caggtacaat gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg     1080

tccgggcagc gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc     1140

ctccgataac tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct     1200

ggatccactg cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac     1260

cactgacctg ggacagtgaa tgtccccctg atctgcggcc gtgactctct taaggtagcc     1320

ttgcagaagt tggtcgtgag gcactgggca ggtaagtatc aaggttacaa gacaggttta     1380

aggagaccaa tagaaactgg gcttgtcgag acagagaaga ctcttgcgtt tctgataggc     1440

acctattggt cttactgaca tccactttgc ctttctctcc acaggtgtcc actcccagtt     1500

caattacagc tcttaaggct agagtactta atacgactca ctataggcta gcgccaccat     1560

ggattccgac gaaactggat ttgaacattc agggctgtgg gtctctgtgc tggctggact     1620

gctgctgggg gcttgtcagg ctcaccccat ccctgacagc tcccctctgc tgcagttcgg     1680

aggacaggtg cggcagagat acctgtatac cgacgatgcc cagcagacag aggcacacct     1740

ggagatcagg gaggacggaa ccgtgggagg agcagccgat cagtctcccg agagcctgct     1800

gcagctgaag gccctgaagc ctggcgtgat ccagatcctg ggcgtgaaga catctcggtt     1860

tctgtgccag cggcccgacg gcgccctgta cggctccctg cacttcgatc ccgaggcctg     1920

ttcttttagg gagctgctgc tggaggacgg ctacaacgtg tatcagagcg aggcacacgg     1980

cctgccactg cacctgcctg gcaataagtc ccctcaccgc gatccagcac ccaggggccc     2040

agcacgcttc ctgcctctgc caggcctgcc ccctgccctg ccagagccac ccggcatcct     2100

ggccccccag cctccagatg tgggctccag cgatcctctg tcaatggtgg ggccaagtca     2160

ggggcggagt ccttcatacg catcataagc ggccgcttcc ctttagtgag ggttaatgct     2220

tcgagcagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg     2280

aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag     2340

ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga     2400

gatgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa tccgataagg     2460

gactagagca tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac     2520

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     2580

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     2640

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     2700

ctgaatggcg aatggaattc cagacgattg agcgtcaaaa tgtaggtatt tccatgagcg     2760

tttttccgtt gcaatggctg gcggtaatat tgttctggat attaccagca aggccgatag     2820

tttgagttct tctactcagg caagtgatgt tattactaat caaagaagta ttgcgacaac     2880

ggttaatttg cgtgatggac agactctttt actcggtggc ctcactgatt ataaaaacac     2940

ttctcaggat tctggcgtac cgttcctgtc taaaatccct ttaatcggcc tcctgtttag     3000

ctcccgctct gattctaacg aggaaagcac gttatacgtg ctcgtcaaag caaccatagt     3060

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     3120

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     3180

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     3240

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     3300

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     3360

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     3420

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     3480

acgcgaattt taacaaaata ttaacgtcta caatttaaat atttgcttat acaatcttcc     3540

tgtttttggg gcttttctga ttatcaaccg gggtacatat gattgacatg ctagttttac     3600

gattaccgtt catcgattct cttgtttgct ccagactctc aggcaatgac ctgatagcct     3660

ttgtagagac ctctcaaaaa tagctaccct ctccggcatg aatttatcag ctagaacggt     3720

tgaatatcat attgatggtg atttgactgt ctccggcctt tctcacccgt ttgaatcttt     3780

acctacacat tactcaggca ttgcatttaa aatatatgag ggttctaaaa atttttatcc     3840

ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag ggtcataatg tttttggtac     3900

aaccgattta gctttatgct ctgaggcttt attgcttaat tttgctaatt ctttgccttg     3960

cctgtatgat ttattggatg ttggaatcgc ctgatgcggt attttctcct tacgcatctg     4020

tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga tgccgcatag     4080

ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc     4140

ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt     4200

tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag     4260

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     4320

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     4380

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     4440

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     4500

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     4560

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     4620

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg     4680

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     4740

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     4800

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     4860

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     4920

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca     4980

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     5040

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     5100

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     5160

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     5220

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     5280

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     5340

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     5400

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     5460

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     5520

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     5580

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     5640

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     5700

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     5760

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     5820

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     5880

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     5940

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     6000

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     6060

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     6120

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     6180

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc     6240

aaaccgcctc tccccgcgcg ttggccgatt cattaatg                             6278


<210>  43
<211>  133
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric intron composed of introns from human beta-globin and 
       immunoglobulin heavy chain genes

<400>  43
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  44
<211>  1671
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CAG promoter

<400>  44
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gttgccttcg ccccgtgccc cgctccgcgc cgcctcgcgc cgcccgcccc      720

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      780

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      840

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg      960

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1020

gtgccccgcg gtgcgggggg ctgcgagggg aacaaaggct gcgtgcgggg tgtgtgcgtg     1080

ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc aaccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtacggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc cccggagcgc cggcggctgt     1320

cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga     1380

cttcctttgt cccaaatctg tgcggagccg aaatctggga ggcgccgccg caccccctct     1440

agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc ctcggggctg tccgcggggg     1560

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1620

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca g              1671


<210>  45
<211>  212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV promoter

<400>  45
gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctgcgatcgc ccgccccgtt gacgcaaatg ggcggtaggc      180

gtgtacggtg ggaggtctat ataagcagag ct                                    212


<210>  46
<211>  380
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV enhancer

<400>  46
ggcattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  47
<211>  397
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hAAT promoter

<400>  47
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agtgaat                               397


<210>  48
<211>  128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated AAV2 5'ITR

<400>  48
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttcct                                                               128


<210>  49
<211>  128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated AAV2 3'ITR

<400>  49
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210>  50
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 polyadenylation signal

<400>  50
taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta       60

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      120

tt                                                                     122


<210>  51
<211>  449
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rabbit beta-globin polyadenylation signal

<400>  51
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt      180

tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga      240

ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg      300

acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta      360

aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc      420

atagctgtcc ctcttctctt atggagatc                                        449


<210>  52
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter and CMV enhancer

<400>  52
ggcattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctgcgatcgc ccgccccgtt      540

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ct              592


<210>  53
<211>  154
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hepatocyte control region (HCR) enhancer from apolipoprotein E

<400>  53
cagagaggtc tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt       60

ttgctgtttg ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt      120

tcagtgtgga cttcagaggc agcacacaaa cagc                                  154


<210>  54
<211>  651
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mini/aP2 promoter

<400>  54
gattaacccg ccatgctact tatctactcg acattgatta ttgactaggg gaattccagc       60

aggaatcagg tagctggaga atcgcacaga gccatgcgat tcttggcaag ccatgcgaca      120

aaggcagaaa tgcacatttc acccagagag aagggattga tgtcagcagg aagtcaccac      180

ccagagagca aatggagttc ccagatgcct gacatttgcc ttcttactgg atcagagttc      240

actagtggaa gtgtcacagc ccaaacactc ccccaaagct cagcccttcc ttgccttgta      300

acaatcaagc cgctcctgga tgaactgctc cgccctctgt ctctttggca gggttggagc      360

ccactgtggc ctgagcgact tctatggctc ccttttctgt gattttcatg gtttctgagc      420

tcttttcccc cgctttatga ttttctcttt ttgtctctct cttgctaaac ctccttcgta      480

tatatgccct ctcaggtttc atttctgaat catctactgt gaactattcc cattgtttgc      540

cagaagcccc ctggttcttc cttctagaca ccaggcaagg ggcaggaggt aagaggcagg      600

agtccataaa acagccctga gagcctgctg ggtcagtgcc tgctgtcaga a               651


<210>  55
<211>  722
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mini/UCP1 promoter

<400>  55
gacgtcacag tgggtcagtc acccttgatc acactgcacc agtcttcacc tttccacgct       60

tcctgccaga gcatgaatca ggctctctgg ggataccggc ctcaccccta ctgaggcaaa      120

ctttctccca cttctcagag gctctgaggg cagcaaggtc agccctttct ttggaatcta      180

gaaccactcc ctgtcttgag ctgacatcac agggcaggca gatgcagcag ggaagggcct      240

gggactggga cgttcatcct acaagaaagc tgtggaactt ttcagcaaca tctcagaaat      300

cagatcgcac ttattcaaag gagccaggcc ctgctctgcg ccctggtgga ggctcctcat      360

gtgaagagtg acaaaaggca ccatgttgtg gatacggggc gaagcccctc cggtgtgtcc      420

tccaggcatc atcaggaact agtgccaaag cagaggtgct ggccagggct ttgggagtga      480

cgcgcgtctg ggaggcttgt gcgcccaggg cacgcccctg ccgattccca ctagcaggtc      540

ttgggggacc tgggccggct ctgcccctcc tccagcaatc gggctataaa gctcttccaa      600

gtcagggcgc agaagtgccg ggcgatccgg gcttaaagag cgagaggaag ggacgctcac      660

ctttgagctc ctccacaaat agccctggtg gctgccacag aagttcgaag ttgagagttc      720

gg                                                                     722


<210>  56
<211>  326
<212>  DNA
<213>  Artificial sequence

<220>
<223>  C5-12 promoter

<400>  56
cggccgtccg ccttcggcac catcctcacg acacccaaat atggcgacgg gtgaggaatg       60

gtggggagtt atttttagag cggtgaggaa ggtgggcagg cagcaggtgt tggcgctcta      120

aaaataactc ccgggagtta tttttagagc ggaggaatgg tggacaccca aatatggcga      180

cggttcctca cccgtcgcca tatttgggtg tccgccctcg gccggggccg cattcctggg      240

ggccgggcgg tgctcccgcc cgcctcgata aaaggctccg gggccggcgg cggcccacga      300

gctacccgga ggagcgggag gcgcca                                           326


<210>  57
<211>  4930
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-EF1a-mmFGF21-pA

<400>  57
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg gctccggtgc ccgtcagtgg gcagagcgca      180

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga      240

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg      300

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg      360

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta      420

cgggttatgg cccttgcgtg ccttgaatta cttccactgg ctgcagtacg tgattcttga      480

tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc      540

ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg      600

gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg      660

atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct      720

gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg      780

cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc      840

tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg      900

ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg      960

ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc     1020

acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga     1080

gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt     1140

aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga     1200

agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg     1260

atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt     1320

gtcgtgagga atttcgactg ctagcacgcg tgatatcaat ggaatggatg agatctagag     1380

ttgggaccct gggactgtgg gtccgactgc tgctggctgt cttcctgctg ggggtctacc     1440

aagcataccc catccctgac tccagccccc tcctccagtt tgggggtcaa gtccggcaga     1500

ggtacctcta cacagatgac gaccaagaca ctgaagccca cctggagatc agggaggatg     1560

gaacagtggt aggcgcagca caccgcagtc cagaaagtct cctggagctc aaagccttga     1620

agccaggggt cattcaaatc ctgggtgtca aagcctctag gtttctttgc caacagccag     1680

atggagctct ctatggatcg cctcactttg atcctgaggc ctgcagcttc agagaactgc     1740

tgctggagga cggttacaat gtgtaccagt ctgaagccca tggcctgccc ctgcgtctgc     1800

ctcagaagga ctccccaaac caggatgcaa catcctgggg acctgtgcgc ttcctgccca     1860

tgccaggcct gctccacgag ccccaagacc aagcaggatt cctgccccca gagcccccag     1920

atgtgggctc ctctgacccc ctgagcatgg tagagccttt acagggccga agccccagct     1980

atgcgtcctg agatatcaaa gaattctaag cttgtcgacg aatgcaattg ttgttaatta     2040

attgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat     2100

ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat     2160

gtatcttagt cgagttaatt aacggcggcc gcaggaaccc ctagtgatgg agttggccac     2220

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     2280

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc aggggcgcct     2340

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatac gtcaaagcaa     2400

ccatagtacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc     2460

gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt     2520

ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc     2580

cgatttagtg ctttacggca cctcgacccc aaaaaacttg atttgggtga tggttcacgt     2640

agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt     2700

aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggg ctattctttt     2760

gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa     2820

aaatttaacg cgaattttaa caaaatatta acgtttacaa ttttatggtg cactctcagt     2880

acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac     2940

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     3000

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc     3060

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     3120

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     3180

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     3240

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     3300

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     3360

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     3420

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     3480

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     3540

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     3600

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     3660

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     3720

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     3780

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     3840

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     3900

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     3960

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     4020

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     4080

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     4140

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     4200

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     4260

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     4320

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     4380

tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag     4440

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     4500

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     4560

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     4620

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     4680

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     4740

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     4800

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     4860

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     4920

gctcacatgt                                                            4930


