                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
       Zhang, Xujia
 
<120>  MIC-1 COMPOUNDS AND USES THEREOF

<130>  170039WO03

<150>  CN2017/085576
<151>  2017-05-23

<150>  CN2017/113335
<151>  2017-11-28

<160>  317   

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  1

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 des-N3

<400>  2

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  3
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1-Del (1-3)

<400>  3

Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
1               5                   10                  15      


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
            20                  25                  30          


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
        35                  40                  45              


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
    50                  55                  60                  


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
65                  70                  75                  80  


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
                85                  90                  95      


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  4

Ser Pro Ala Gly Ser Pro 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  5

Thr Ser Glu Ser Ala Thr 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  6

Thr Ser Thr Glu Pro Glu 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  7

Ser Glu Pro Ala Thr Ser 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  8

Thr Ser Thr Glu Glu Gly 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  9

Pro Glu Ser Gly Pro Gly 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  10

Ser Gly Ser Ala Pro Gly 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  11

Gly Ser Glu Thr Pro Gly 
1               5       


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  12

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  13

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  14

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly 
            20                  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  15

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 
            20                  25                  30  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  16

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 
            20                  25                  30  


<210>  17
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  17

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 
            20                  25                  30  


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  18

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  19

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  20

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  21

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Glu 
            20                  25                  30  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  22

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Glu 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  23

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Glu 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  24

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  25

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  26

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  27
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  27

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  28
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  28

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  29

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  30

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Pro Glu Ser Gly Pro Gly 
            20                  25                  30  


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  31

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Pro Glu Ser Gly Pro Gly 
            20                  25                  30  


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  32

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Pro Glu Ser Gly Pro Gly 
            20                  25                  30  


<210>  33
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  33

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Gly Ser Ala Pro Gly 
            20                  25                  30  


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  34

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Gly Ser Ala Pro Gly 
            20                  25                  30  


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  35

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Gly Ser Ala Pro Gly 
            20                  25                  30  


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  36

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Gly Ser Glu Thr Pro Gly 
            20                  25                  30  


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  37

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Ser Glu Thr Pro Gly 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  38

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Gly Ser Glu Thr Pro Gly 
            20                  25                  30  


<210>  39
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  39

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  40
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  40

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  41
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  41

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  42
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  42

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  43
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  43

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  44
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  44

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  45
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  45

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly 
        35      


<210>  46
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  46

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  47
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  47

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  48
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  48

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  49
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  49

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly 
        35      


<210>  50
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  50

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  51
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  51

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  52
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  52

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  53
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  53

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly 
        35      


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  54

Ala Glu Glu Ala Glu Ser 
1               5       


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  55

Ala Glu Ser Met 
1               


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  56

Ala Glu Glu Ala Glu Glu Ala Glu Ser 
1               5                   


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  57

Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
1               5                   10                  15      


Gly Glu Pro Ser 
            20  


<210>  58
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  58

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  


<210>  59
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  59

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala 
1               5                   10                  15      


Glu Glu Ala Glu Ser 
            20      


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  60

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala 
1               5                   10                  15      


Glu Ser 
        


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  61

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Ser 
1               5                   10          


<210>  62
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  62

Ala Ala Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  25      


<210>  63
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  63

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  


<210>  64
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  64

Ala Ala Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  25      


<210>  65
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  65

Ala Ala Pro Glu Asp Glu Glu Thr Pro Glu Gln Glu Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser 
            20          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  66

Ala Ala Pro Glu Asp Glu Glu Thr Pro Glu Gln Glu 
1               5                   10          


<210>  67
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  67

Ala Ala Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser 
            20          


<210>  68
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  68

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly 
            20                  


<210>  69
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  69

Ala Gly Pro Glu Gln Gly Gln Glu Pro Gly Pro Glu Gln Gly Gln Glu 
1               5                   10                  15      


Pro Gly Pro Glu Gln Gly Gln Glu Pro 
            20                  25  


<210>  70
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  70

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  71

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  72
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  72

Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
1               5                   10                  15      


Gly Glu Pro Ser Gly Glu Pro Ser 
            20                  


<210>  73
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  73

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  74
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  74

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Glu Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  75
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  75

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Glu Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  76
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  76

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu Glu Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  77
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  77

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Glu Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  78
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  78

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Glu Asp Cys His Cys Ile 
            100                 105                 110         


<210>  79
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  79

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Glu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  80
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  80

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Glu Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  81
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  81

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Glu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  82
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  82

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  83
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  83

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Glu Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  84
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  84

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Glu Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  85
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  85

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Glu Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  86
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  86

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Glu Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  87
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  87

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Glu Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  88
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  88

Ala Ala Glu Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Glu Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  89
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  89

Ala Glu Glu Ala Glu Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
1               5                   10                  15      


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
            20                  25                  30          


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
        35                  40                  45              


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
    50                  55                  60                  


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
65                  70                  75                  80  


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
                85                  90                  95      


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
            100                 105                 110         


His Cys Ile 
        115 


<210>  90
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  90

Ala Glu Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  91
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  91

Ala Glu Glu Ala Glu Glu Ala Glu Ser Gly Asp His Cys Pro Leu Gly 
1               5                   10                  15      


Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp 
            20                  25                  30          


Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr 
        35                  40                  45              


Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His 
    50                  55                  60                  


Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro 
65                  70                  75                  80  


Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln 
                85                  90                  95      


Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala 
            100                 105                 110         


Lys Asp Cys His Cys Ile 
        115             


<210>  92
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  92

Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
1               5                   10                  15      


Gly Glu Pro Ser Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
            20                  25                  30          


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
        35                  40                  45              


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
    50                  55                  60                  


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
65                  70                  75                  80  


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
                85                  90                  95      


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
            100                 105                 110         


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
        115                 120                 125             


Cys His Cys Ile 
    130         


<210>  93
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  93

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ala Arg Asn Gly Asp His Cys Pro 
            20                  25                  30          


Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu 
        35                  40                  45              


Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln 
    50                  55                  60                  


Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn 
65                  70                  75                  80  


Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr 
                85                  90                  95      


Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu 
            100                 105                 110         


Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu 
        115                 120                 125             


Leu Ala Lys Asp Cys His Cys Ile 
    130                 135     


<210>  94
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  94

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala 
1               5                   10                  15      


Glu Glu Ala Glu Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys 
            20                  25                  30          


Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala 
        35                  40                  45              


Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly 
    50                  55                  60                  


Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys 
65                  70                  75                  80  


Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys 
                85                  90                  95      


Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr 
            100                 105                 110         


Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His 
        115                 120                 125             


Cys Ile 
    130 


<210>  95
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  95

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala 
1               5                   10                  15      


Glu Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
            20                  25                  30          


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
        35                  40                  45              


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
    50                  55                  60                  


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
65                  70                  75                  80  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
                85                  90                  95      


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
            100                 105                 110         


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
        115                 120                 125         


<210>  96
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  96

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Ser Gly Asp His Cys 
1               5                   10                  15      


Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser 
            20                  25                  30          


Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val 
        35                  40                  45              


Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala 
    50                  55                  60                  


Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp 
65                  70                  75                  80  


Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val 
                85                  90                  95      


Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp 
            100                 105                 110         


Leu Leu Ala Lys Asp Cys His Cys Ile 
        115                 120     


<210>  97
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  97

Ala Ala Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ala Arg Asn Gly Asp His 
            20                  25                  30          


Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala 
        35                  40                  45              


Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu 
    50                  55                  60                  


Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala 
65                  70                  75                  80  


Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro 
                85                  90                  95      


Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met 
            100                 105                 110         


Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp 
        115                 120                 125             


Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135             


<210>  98
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  98

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ala Ala Glu Gly Asp His Cys Pro 
            20                  25                  30          


Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu 
        35                  40                  45              


Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln 
    50                  55                  60                  


Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn 
65                  70                  75                  80  


Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr 
                85                  90                  95      


Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu 
            100                 105                 110         


Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu 
        115                 120                 125             


Leu Ala Lys Asp Cys His Cys Ile 
    130                 135     


<210>  99
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  99

Ala Ala Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Gly Asp His Cys Pro Leu 
            20                  25                  30          


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
        35                  40                  45              


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
    50                  55                  60                  


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
65                  70                  75                  80  


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
                85                  90                  95      


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
            100                 105                 110         


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
        115                 120                 125             


Ala Lys Asp Cys His Cys Ile 
    130                 135 


<210>  100
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  100

Ala Ala Pro Glu Asp Glu Glu Thr Pro Glu Gln Glu Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
            20                  25                  30          


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
        35                  40                  45              


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
    50                  55                  60                  


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
65                  70                  75                  80  


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
                85                  90                  95      


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
            100                 105                 110         


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
        115                 120                 125             


His Cys Ile 
    130     


<210>  101
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  101

Ala Ala Pro Glu Asp Glu Glu Thr Pro Glu Gln Glu Gly Asp His Cys 
1               5                   10                  15      


Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser 
            20                  25                  30          


Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val 
        35                  40                  45              


Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala 
    50                  55                  60                  


Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp 
65                  70                  75                  80  


Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val 
                85                  90                  95      


Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp 
            100                 105                 110         


Leu Leu Ala Lys Asp Cys His Cys Ile 
        115                 120     


<210>  102
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  102

Ala Ala Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
            20                  25                  30          


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
        35                  40                  45              


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
    50                  55                  60                  


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
65                  70                  75                  80  


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
                85                  90                  95      


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
            100                 105                 110         


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
        115                 120                 125             


His Cys Ile 
    130     


<210>  103
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  103

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  104
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  104

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  105
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  105

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  106
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  106

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Leu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  107
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  107

Ala Gly Pro Glu Gln Gly Gln Glu Pro Gly Pro Glu Gln Gly Gln Glu 
1               5                   10                  15      


Pro Gly Pro Glu Gln Gly Gln Glu Pro Gly Asp His Cys Pro Leu Gly 
            20                  25                  30          


Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp 
        35                  40                  45              


Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr 
    50                  55                  60                  


Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His 
65                  70                  75                  80  


Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro 
                85                  90                  95      


Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln 
            100                 105                 110         


Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala 
        115                 120                 125             


Lys Asp Cys His Cys Ile 
    130                 


<210>  108
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  108

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  109
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  109

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  110
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  110

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  111
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  111

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Leu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  112
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  112

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu Glu Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  113
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  113

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Glu Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  114
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  114

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Glu Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  115
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  115

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Gly Gly 
            20                  25                  30          


Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val 
        35                  40                  45              


Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro 
    50                  55                  60                  


Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe 
65                  70                  75                  80  


Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu 
                85                  90                  95      


Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn 
            100                 105                 110         


Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr 
        115                 120                 125             


Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140 


<210>  116
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  116

Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
1               5                   10                  15      


Gly Glu Pro Ser Gly Glu Pro Ser Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  117
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  117

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ala Arg Gly Asp His Cys Pro Leu 
            20                  25                  30          


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
        35                  40                  45              


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
    50                  55                  60                  


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
65                  70                  75                  80  


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
                85                  90                  95      


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
            100                 105                 110         


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
        115                 120                 125             


Ala Lys Asp Cys His Cys Ile 
    130                 135 


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  118

Gly Glu Pro Ser 
1               


<210>  119
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  119

Gly Pro Ser Glu 
1               


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  120

Gly Pro Glu Ser 
1               


<210>  121
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  121

Gly Ser Pro Glu 
1               


<210>  122
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  122

Gly Ser Glu Pro 
1               


<210>  123
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  123

Gly Glu Pro Gln 
1               


<210>  124
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  124

Gly Glu Gln Pro 
1               


<210>  125
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  125

Gly Pro Glu Gln 
1               


<210>  126
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  126

Gly Pro Gln Glu 
1               


<210>  127
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  127

Gly Gln Glu Pro 
1               


<210>  128
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  128

Gly Gln Pro Glu 
1               


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  129

Pro Glu Asp Glu Glu Thr Pro Glu Gln Glu 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  130

Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  131

Pro Ala Ala Glu Glu Glu Asp Asp Pro Asp 
1               5                   10  


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  132

Ala Glu Pro Asp Glu Asp Pro Gln Ser Glu Asp 
1               5                   10      


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  133

Ala Glu Pro Asp Glu Asp Pro Gln Ser Glu 
1               5                   10  


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  134

Ala Glu Pro Glu Glu Gln Glu Glu Asp 
1               5                   


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  135

Ala Glu Pro Glu Glu Gln Glu Glu 
1               5               


<210>  136
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  136

Gly Gly Gly Ser 
1               


<210>  137
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  137

Gly Ser Gly Ser 
1               


<210>  138
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  138

Gly Gly Ser Ser 
1               


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  139

Ser Ser Ser Gly 
1               


<210>  140
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  140

Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
1               5                   10                  15      


Gly Glu Pro Ser 
            20  


<210>  141
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  141

Gly Pro Ser Glu Gly Pro Ser Glu Gly Pro Ser Glu Gly Pro Ser Glu 
1               5                   10                  15      


Gly Pro Ser Glu 
            20  


<210>  142
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  142

Gly Pro Glu Ser Gly Pro Glu Ser Gly Pro Glu Ser Gly Pro Glu Ser 
1               5                   10                  15      


Gly Pro Glu Ser 
            20  


<210>  143
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  143

Gly Ser Pro Glu Gly Ser Pro Glu Gly Ser Pro Glu Gly Ser Pro Glu 
1               5                   10                  15      


Gly Ser Pro Glu 
            20  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  144

Gly Ser Glu Pro Gly Ser Glu Pro Gly Ser Glu Pro Gly Ser Glu Pro 
1               5                   10                  15      


Gly Ser Glu Pro 
            20  


<210>  145
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  145

Gly Glu Pro Gln Gly Glu Pro Gln Gly Glu Pro Gln Gly Glu Pro Gln 
1               5                   10                  15      


Gly Glu Pro Gln 
            20  


<210>  146
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  146

Gly Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro 
1               5                   10                  15      


Gly Glu Gln Pro 
            20  


<210>  147
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  147

Gly Pro Glu Gln Gly Pro Glu Gln Gly Pro Glu Gln Gly Pro Glu Gln 
1               5                   10                  15      


Gly Pro Glu Gln 
            20  


<210>  148
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  148

Gly Pro Gln Glu Gly Pro Gln Glu Gly Pro Gln Glu Gly Pro Gln Glu 
1               5                   10                  15      


Gly Pro Gln Glu 
            20  


<210>  149
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  149

Gly Gln Glu Pro Gly Gln Glu Pro Gly Gln Glu Pro Gly Gln Glu Pro 
1               5                   10                  15      


Gly Gln Glu Pro 
            20  


<210>  150
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  150

Gly Gln Pro Glu Gly Gln Pro Glu Gly Gln Pro Glu Gly Gln Pro Glu 
1               5                   10                  15      


Gly Gln Pro Glu 
            20  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  151

Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu Ala Glu Glu 
1               5                   10                  15  


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  152

Gly Gly Ser Ser Ser Gly Ser 
1               5           


<210>  153
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  153

Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr 
1               5                   10                  15      


Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro 
            20                  25                  30      


<210>  154
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  154

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Leu Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  155
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  155

Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
1               5                   10                  15      


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
            20                  25                  30          


Pro Arg Glu Val Gln Val Thr Leu Cys Ile Gly Ala Cys Pro Ser Gln 
        35                  40                  45              


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
    50                  55                  60                  


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
65                  70                  75                  80  


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
                85                  90                  95      


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 


<210>  156
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  156

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Glu His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


Glu Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  157
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  157

Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
1               5                   10                  15      


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
            20                  25                  30          


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
        35                  40                  45              


Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg 
    50                  55                  60                  


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
65                  70                  75                  80  


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
                85                  90                  95      


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 


<210>  158
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  158

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  159
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  159

Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
1               5                   10                  15      


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
            20                  25                  30          


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
        35                  40                  45              


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
    50                  55                  60                  


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
65                  70                  75                  80  


Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
                85                  90                  95      


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 


<210>  160
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  160

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  161
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  161

Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
1               5                   10                  15      


Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser Gly Glu Pro Ser 
            20                  25                  30          


Gly Glu Pro Ser 
        35      


<210>  162
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  162

Gly Glu Pro Gln Gly Glu Pro Gln Gly Glu Pro Gln Gly Glu Pro Gln 
1               5                   10                  15      


Gly Glu Pro Gln Gly Glu Pro Gln Gly Glu Pro Gln Gly Glu Pro Gln 
            20                  25                  30          


Gly Glu Pro Gln 
        35      


<210>  163
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  163

Ala Gly Pro Glu Gln Gly Gln Glu Pro Gly Glu Pro Gln Gly Gln Glu 
1               5                   10                  15      


Pro Gln Pro Gly Glu Pro Glu Gly Gln 
            20                  25  


<210>  164
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  164

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  165
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  165

Ala Gly Pro Glu Gln Gly Gln Glu Pro Gly Glu Pro Gln Gly Gln Glu 
1               5                   10                  15      


Pro Gln Pro Gly Glu Pro Glu Gly Gln Gly Asp His Cys Pro Leu Gly 
            20                  25                  30          


Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp 
        35                  40                  45              


Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr 
    50                  55                  60                  


Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His 
65                  70                  75                  80  


Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro 
                85                  90                  95      


Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln 
            100                 105                 110         


Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala 
        115                 120                 125             


Lys Asp Cys His Cys Ile 
    130                 


<210>  166
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  166

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
1               5                   10          


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  167

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
1               5                   10          


<210>  168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  168

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
1               5                   10          


<210>  169
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  169

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 
1               5                   10          


<210>  170
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  170

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly 
            20                  


<210>  171
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  171

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly 
            20                  


<210>  172
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  172

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly 
            20                  


<210>  173
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-teminal extension

<400>  173

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly 
            20                  


<210>  174
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-external extension

<400>  174

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  


<210>  175
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  175

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly 
            20                  


<210>  176
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  176

Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly 
            20                  


<210>  177
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  177

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly 
            20                  


<210>  178
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  178

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  


<210>  179
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  179

Thr Ser Thr Glu Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly 
            20                  


<210>  180
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  180

Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly 
            20                  


<210>  181
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  181

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly 
            20                  


<210>  182
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide plus N-terminal extension

<400>  182

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  183
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  183

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Glu Ser Ala Thr Pro Glu 
            20                  25                  30  


<210>  184
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  184

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Glu Pro Ser Glu 
            20                  25                  30  


<210>  185
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  185

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  186
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  186

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  187
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  187

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30  


<210>  188
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  188

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  189
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  189

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  190
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  190

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  191
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  191

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Glu Ser Ala Thr Pro Glu 
            20                  25                  30  


<210>  192
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  192

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30  


<210>  193
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  193

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Glu Pro Ser Glu 
            20                  25                  30  


<210>  194
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  194

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  195
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  195

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Pro Glu Gln Gly Pro Glu Gln 
            20                  25                  30          


<210>  196
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  196

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Glu Pro Ser Gly Glu Pro Ser 
            20                  25                  30          


<210>  197
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  197

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  198
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  198

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


<210>  199
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  199

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
    50                  55                  60  


<210>  200
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  200

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Glu Gly Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  201
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  201

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  202
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  202

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Glu Ser Ala Thr Pro Glu Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  203
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  203

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Glu Pro Ser Glu Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  204
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  204

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  205
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  205

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Glu Gly Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  206
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  206

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  207
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  207

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  208
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  208

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  209
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  209

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Glu Gly Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  210
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  210

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  211
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  211

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Glu Ser Ala Thr Pro Glu Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  212
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  212

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  213
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  213

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Glu Pro Ser Glu Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  214
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  214

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  215
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  215

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Pro Glu Gln Gly Pro Glu Gln 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  216
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  216

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Glu Pro Ser Gly Glu Pro Ser 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  217
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  217

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
        35                  40                  45              


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
    50                  55                  60                  


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
65                  70                  75                  80  


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
                85                  90                  95      


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
            100                 105                 110         


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
        115                 120                 125             


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
    130                 135                 140                 


His Cys Ile 
145         


<210>  218
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  218

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
        35                  40                  45              


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    50                  55                  60                  


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
65                  70                  75                  80  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                85                  90                  95      


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            100                 105                 110         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        115                 120                 125             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    130                 135                 140                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
145                 150                 155                 


<210>  219
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  219

Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 
        35                  40                  45              


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Arg Asn Gly 
    50                  55                  60                  


Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val 
65                  70                  75                  80  


Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro 
                85                  90                  95      


Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe 
            100                 105                 110         


Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu 
        115                 120                 125             


Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn 
    130                 135                 140                 


Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr 
145                 150                 155                 160 


Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                165                 170         


<210>  220
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  220

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu Glu Glu Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  221
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  221

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Gly Asp 
            20                  25                  30          


His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
        35                  40                  45              


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
    50                  55                  60                  


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
65                  70                  75                  80  


Ala Ala Asn Glu His Ala Gln Ile Lys Thr Ser Leu His Glu Leu Lys 
                85                  90                  95      


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
            100                 105                 110         


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
        115                 120                 125             


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 


<210>  222
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  222

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  223
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  223

Ser Glu Pro Ala Thr Cys Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30  


<210>  224
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  224

Ser Glu Pro Ala Thr Ser Gly Cys Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30  


<210>  225
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  225

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  226
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  226

Ser Glu Pro Ala Thr Cys Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  227
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  227

Ser Glu Pro Ala Thr Ser Cys Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  228
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  228

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  229
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  229

Ser Glu Pro Ala Cys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  230
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  230

Ser Glu Pro Ala Thr Ser Gly Cys Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  231
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  231

Ser Glu Pro Ala Thr Ser Gly Ser Glu Cys Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  232
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  232

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Cys Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  233
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  233

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Cys Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  234
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  234

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Cys 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  235
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  235

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Cys Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  236
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  236

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Cys Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  237
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  237

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Cys Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  238
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  238

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Cys Glu Pro Ser Glu Gly 
            20                  25                  30          


<210>  239
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  239

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Cys Glu Gly 
            20                  25                  30          


<210>  240
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  240

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30  


<210>  241
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  241

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 
            20                  25              


<210>  242
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  242

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  


<210>  243
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  243

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser 
            20      


<210>  244
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  244

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly 
1               5                   10          


<210>  245
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  245

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 
            20                  25                  30  


<210>  246
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  246

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 
            20                  25                  30  


<210>  247
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  247

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 
            20                  25                  30  


<210>  248
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  248

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  249
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  249

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  250
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  250

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
            20                  25                  30  


<210>  251
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  251

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Glu 
            20                  25                  30  


<210>  252
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  252

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Glu 
            20                  25                  30  


<210>  253
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  253

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Glu 
            20                  25                  30  


<210>  254
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  254

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  255
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  255

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  256
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  256

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 
            20                  25                  30  


<210>  257
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  257

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  258
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  258

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  259
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  259

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu Glu Gly 
            20                  25                  30  


<210>  260
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  260

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Pro Glu Ser Gly Pro Gly 
            20                  25                  30  


<210>  261
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  261

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Pro Glu Ser Gly Pro Gly 
            20                  25                  30  


<210>  262
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  262

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Pro Glu Ser Gly Pro Gly 
            20                  25                  30  


<210>  263
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  263

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Gly Ser Ala Pro Gly 
            20                  25                  30  


<210>  264
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  264

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Gly Ser Ala Pro Gly 
            20                  25                  30  


<210>  265
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  265

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Gly Ser Ala Pro Gly 
            20                  25                  30  


<210>  266
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  266

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Gly Ser Glu Thr Pro Gly 
            20                  25                  30  


<210>  267
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  267

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Gly Ser Glu Thr Pro Gly 
            20                  25                  30  


<210>  268
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  268

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Gly Ser Glu Thr Pro Gly 
            20                  25                  30  


<210>  269
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  269

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  270
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  270

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  271
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  271

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 
1               5                   10                  15      


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  272
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  272

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  273
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  273

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  274
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  274

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  275
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  275

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly 
        35      


<210>  276
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  276

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  277
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  277

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  278
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  278

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  279
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  279

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu 
1               5                   10                  15      


Pro Glu Ser Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly 
        35      


<210>  280
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  280

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
            20                  25                  30          


Thr Glu Glu Gly 
        35      


<210>  281
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  281

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            20                  25                  30          


Ser Gly Pro Gly 
        35      


<210>  282
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  282

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Glu Ser Gly 
            20                  25                  30          


Ser Ala Pro Gly 
        35      


<210>  283
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  283

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 
            20                  25                  30          


Glu Thr Pro Gly 
        35      


<210>  284
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  284

Gly Pro Cys Glu Gly Pro Ser Glu Gly Pro Ser Glu Gly Pro Ser Glu 
1               5                   10                  15      


Gly Pro Ser Glu Gly Pro Ser Glu Gly Pro Ser Glu 
            20                  25              


<210>  285
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  285

Gly Glu Cys Pro Gly Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro 
1               5                   10                  15      


Gly Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro 
            20                  25              


<210>  286
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  286

Pro Ala Cys Glu Glu Glu Asp Asp Pro Asp Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser 
            20          


<210>  287
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  287

Pro Asp Glu Cys Thr Glu Glu Glu Thr Glu Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser 
            20          


<210>  288
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  288

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  289
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  289

Ser Glu Pro Ala Thr Ser Cys Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  290
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  290

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  291
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  291

Ser Glu Pro Ala Thr Cys Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  292
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  292

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Cys Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  293
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  293

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Cys Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  294
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  294

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Glu His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu Glu Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  295
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  295

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  296
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  296

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Ala Arg 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  297
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  297

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  298
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  298

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Ala Arg 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  299
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  299

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Ala Arg 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  300
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  300

Ser Ala Pro Ala Thr Ser Gly Ser Ala Thr Pro Gly Ser Ala Pro Ala 
1               5                   10                  15      


Thr Ser Gly Ser Ala Thr Pro Gly Gly Asp His Cys Pro Leu Gly Pro 
            20                  25                  30          


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
        35                  40                  45              


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
    50                  55                  60                  


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
                85                  90                  95      


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
            100                 105                 110         


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
        115                 120                 125             


Asp Cys His Cys Ile 
    130             


<210>  301
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  301

Ser Glu Pro Cys Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Ala Arg 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  302
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  302

Ser Glu Pro Ala Thr Cys Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Ala Arg 
            20                  25                  30          


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
        35                  40                  45              


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
    50                  55                  60                  


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
65                  70                  75                  80  


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
                85                  90                  95      


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
            100                 105                 110         


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
        115                 120                 125             


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140     


<210>  303
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  303

Ser Glu Pro Ala Thr Ser Gly Cys Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  304
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  304

Ser Glu Pro Ala Thr Ser Gly Ser Glu Cys Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  305
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  305

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Cys Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  306
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  306

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Cys Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  307
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  307

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Cys 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  308
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  308

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Cys Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  309
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  309

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Cys Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  310
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  310

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Cys Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140             


<210>  311
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  311

Glu Glu Ala Glu Ala Asp Asp Asp Asp Lys Glu Ser Gly Asp His Cys 
1               5                   10                  15      


Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser 
            20                  25                  30          


Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val 
        35                  40                  45              


Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala 
    50                  55                  60                  


Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp 
65                  70                  75                  80  


Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val 
                85                  90                  95      


Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp 
            100                 105                 110         


Leu Leu Ala Lys Asp Cys His Cys Ile 
        115                 120     


<210>  312
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  312

Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
1               5                   10                  15      


Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 
            20                  25                  30          


Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
        35                  40                  45              


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
    50                  55                  60                  


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
65                  70                  75                  80  


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
                85                  90                  95      


His Arg Leu Arg Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
            100                 105                 110         


Ser Tyr Asn Pro Leu Val Leu Ile Gln Arg Thr Asp Thr Gly Val Ser 
        115                 120                 125             


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
    130                 135                 140             


<210>  313
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  313

Glu Glu Ala Glu Ala Asp Asp Asp Asp Lys 
1               5                   10  


<210>  314
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  314

Glu Ser Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110     


<210>  315
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide

<400>  315

Ala Arg Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
1               5                   10                  15      


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
            20                  25                  30          


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
        35                  40                  45              


Ser Gln Phe Arg Ala Ala Asn Leu His Ala Gln Ile Lys Thr Ser Leu 
    50                  55                  60                  


His Arg Leu Arg Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
65                  70                  75                  80  


Ser Tyr Asn Pro Leu Val Leu Ile Gln Arg Thr Asp Thr Gly Val Ser 
                85                  90                  95      


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110     


<210>  316
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIC-1 polypeptide with N-terminal extension

<400>  316

Gly Glu Gln Pro Cys Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro 
1               5                   10                  15      


Gly Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro Ala Arg Asn Gly 
            20                  25                  30          


Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val 
        35                  40                  45              


Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro 
    50                  55                  60                  


Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe 
65                  70                  75                  80  


Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu 
                85                  90                  95      


Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn 
            100                 105                 110         


Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr 
        115                 120                 125             


Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
    130                 135                 140 


<210>  317
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  317

Gly Glu Gln Pro Cys Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro 
1               5                   10                  15      


Gly Glu Gln Pro Gly Glu Gln Pro Gly Glu Gln Pro 
            20                  25              


