                         SEQUENCE LISTING

<110>  Case Western Reserve University
 
<120>  COMPOSITIONS AND METHODS FOR EXPANDING EX VIVO NATURAL KILLER 
       CELLS AND THERAPEUTIC USES THEREOF

<130>  CASEU-57518WO

<150>  US 62/508,666
<151>  2017-05-19

<150>  US 62/538,961
<151>  2017-07-31

<150>  US 62/578,742
<151>  2017-10-30

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mbIL-21

<400>  1

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Asp Arg His Met Ile Arg Met Arg Gln 
            20                  25                  30          


Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val 
        35                  40                  45              


Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp 
    50                  55                  60                  


Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr 
65                  70                  75                  80  


Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg 
                85                  90                  95      


Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr 
            100                 105                 110         


Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu 
        115                 120                 125             


Glu Arg Phe Lys Ser Leu Leu Gln Lys Val Ser Thr Leu Ser Phe Ile 
    130                 135                 140                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                245                 250                 255     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Leu Gly Lys Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly 
    370                 375                 380                 


Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe 
385                 390                 395 


<210>  2
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mbIL-21

<400>  2
atgctcttgc tcgtcacctc cttgctgctg tgtgaactgc cgcaccctgc gttccttctt       60

attccacagg accgacacat gatccgaatg cgccaactca tagacatcgt agaccagctc      120

aagaattatg tcaacgacct ggtgcctgag ttcctcccgg ctccagagga cgtcgaaaca      180

aactgcgaat ggtctgcttt tagctgtttt caaaaggcgc agttgaaatc agcgaacacg      240

ggcaataatg agcgcattat taacgtctca atcaagaaac tgaaaagaaa gccaccgtca      300

acaaatgctg ggcgacggca gaaacataga cttacctgcc caagctgtga ctcctacgag      360

aaaaagccgc cgaaagagtt tcttgaaagg ttcaagagcc tcctccagaa ggtgtctacc      420

ctgagcttca tcgaatccaa gtacggtccc ccatgtcccc cgtgccccgc ccctgagttt      480

ctggggggtc cttcagtttt tctgttcccg ccaaagccaa aggacactct gatgatatcc      540

agaacaccgg aggttacttg tgtcgtggtc gatgttagcc aagaggaccc cgaagttcag      600

ttcaactggt atgtcgacgg cgtggaagtc cataatgcaa aaacgaaacc acgggaagag      660

caattcaata gcacctacag agtagtatca gttctgaccg ttctgcatca agactggctc      720

aacggtaaag aatacaagtg caaagtgtct aataaaggct tgcctagttc catagaaaag      780

accatcagca aggcgaaagg gcaaccacga gagccacaag tctatacgct tcccccatca      840

caagaagaaa tgacgaagaa ccaagtgagc ttgacgtgct tggtgaaggg tttttacccg      900

tcagacatag ccgtcgagtg ggaatcaaat ggccagcccg agaacaatta caaaacaact      960

ccacccgttc tcgactccga cggttccttt ttcctctact cacgattgac tgtagataag     1020

agcagatggc aagagggaaa tgtgttctct tgtagcgtga tgcacgaagc actccataac     1080

cactacactc agaaatcact ctctctcagt cttgggaaaa tggcactcat tgtgctcggt     1140

ggggtggcag gtcttcttct gtttattggc cttggaatat ttttc                     1185


<210>  3
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mbIL-15

<400>  3

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Glu Ser Lys Tyr Gly Pro Pro Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Ala Leu 
        355                 360                 365             


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
    370                 375                 380                 


Ile Phe Phe 
385         


<210>  4
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct mbIL-15

<400>  4
atgctgcttc tcgtaacgtc cttgttgttg tgcgaattgc ctcatccagc attcttgctt       60

attcccaact gggtcaacgt aataagtgac ttgaaaaaaa tcgaggatct gatacagagt      120

atgcacatcg atgcaacact ctacactgag agtgatgttc acccgagttg taaagtgaca      180

gcgatgaaat gttttcttct tgaacttcag gttatatcac ttgaatcagg tgatgctagt      240

atccatgaca cggtggagaa tctcatcatt cttgctaata acagtctctc ctcaaatggt      300

aatgtaacag aatctggctg taaagaatgc gaggaattgg aggagaagaa cataaaggaa      360

tttctccaga gcttcgtcca tatagtacag atgttcatca acacatccga gtctaaatac      420

ggcccgccgt gtccaccgtg tccagcgcca gagtttctcg gtggcccttc tgtgttcctg      480

ttccccccca agcccaaaga tacccttatg atatcaagaa caccagaagt cacttgtgtc      540

gttgtcgatg tgagccaaga agaccctgag gtacagttca actggtatgt agatggggtt      600

gaggttcata acgccaaaac taagcccaga gaagaacaat tcaatagtac ttatagagtt      660

gtctcagtac ttacggtctt gcatcaagat tggttgaatg gtaaggaata taagtgcaaa      720

gtgtccaata agggcctgcc aagcagtata gagaagacta tctccaaggc aaaagggcaa      780

ccccgcgaac cacaggtcta tactcttcca cccagccaag aggaaatgac taaaaatcaa      840

gtatctctta cgtgccttgt gaaaggtttt tacccgagtg atattgccgt agagtgggaa      900

tccaacggcc agccagagaa caactataag actacgccgc cggttttgga tagtgacggc      960

tccttctttc tgtactccag gctcacggtc gacaagagtc gatggcaaga ggggaacgta     1020

tttagttgct ctgtgatgca tgaagcgctg cacaatcatt atactcagaa gagtctgtcc     1080

ctgagtctcg gcaaaatggc cctgattgta ctgggagggg ttgctggact tctcctgttt     1140

atcggactcg gtatcttctt ctga                                            1164


<210>  5
<211>  9680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg ctcttgctcg     3180

tcacctcctt gctgctgtgt gaactgccgc accctgcgtt ccttcttatt ccacaggacc     3240

gacacatgat ccgaatgcgc caactcatag acatcgtaga ccagctcaag aattatgtca     3300

acgacctggt gcctgagttc ctcccggctc cagaggacgt cgaaacaaac tgcgaatggt     3360

ctgcttttag ctgttttcaa aaggcgcagt tgaaatcagc gaacacgggc aataatgagc     3420

gcattattaa cgtctcaatc aagaaactga aaagaaagcc accgtcaaca aatgctgggc     3480

gacggcagaa acatagactt acctgcccaa gctgtgactc ctacgagaaa aagccgccga     3540

aagagtttct tgaaaggttc aagagcctcc tccagaaggt gtctaccctg agcttcatcg     3600

aatccaagta cggtccccca tgtcccccgt gccccgcccc tgagtttctg gggggtcctt     3660

cagtttttct gttcccgcca aagccaaagg acactctgat gatatccaga acaccggagg     3720

ttacttgtgt cgtggtcgat gttagccaag aggaccccga agttcagttc aactggtatg     3780

tcgacggcgt ggaagtccat aatgcaaaaa cgaaaccacg ggaagagcaa ttcaatagca     3840

cctacagagt agtatcagtt ctgaccgttc tgcatcaaga ctggctcaac ggtaaagaat     3900

acaagtgcaa agtgtctaat aaaggcttgc ctagttccat agaaaagacc atcagcaagg     3960

cgaaagggca accacgagag ccacaagtct atacgcttcc cccatcacaa gaagaaatga     4020

cgaagaacca agtgagcttg acgtgcttgg tgaagggttt ttacccgtca gacatagccg     4080

tcgagtggga atcaaatggc cagcccgaga acaattacaa aacaactcca cccgttctcg     4140

actccgacgg ttcctttttc ctctactcac gattgactgt agataagagc agatggcaag     4200

agggaaatgt gttctcttgt agcgtgatgc acgaagcact ccataaccac tacactcaga     4260

aatcactctc tctcagtctt gggaaaatgg cactcattgt gctcggtggg gtggcaggtc     4320

ttcttctgtt tattggcctt ggaatatttt tcgcccagct ttcttgtaca aagtggtgat     4380

aatcgaattc cgataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc     4440

ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg     4500

ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc     4560

tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg     4620

acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg     4680

ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga     4740

caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaag ctgacgtcct     4800

ttccatggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg     4860

tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc     4920

ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc     4980

cgcatcggga attcccgcgg ttcgaattct accgggtagg ggaggcgctt ttcccaaggc     5040

agtctggagc atgcgcttta gcagccccgc tgggcacttg gcgctacaca agtggcctct     5100

ggcctcgcac acattccaca tccaccggta ggcgccaacc ggctccgttc tttggtggcc     5160

ccttcgcgcc accttctact cctcccctag tcaggaagtt cccccccgcc ccgcagctcg     5220

cgtcgtgcag gacgtgacaa atggaagtag cacgtctcac tagtctcgtg cagatggaca     5280

gcaccgctga gcaatggaag cgggtaggcc tttggggcag cggccaatag cagctttgct     5340

ccttcgcttt ctgggctcag aggctgggaa ggggtgggtc cgggggcggg ctcaggggcg     5400

ggctcagggg cggggcgggc gcccgaaggt cctccggagg cccggcattc tgcacgcttc     5460

aaaagcgcac gtctgccgcg ctgttctcct cttcctcatc tccgggcctt tcgacctcac     5520

gtggccacca tgaccgagta caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc     5580

agggccgtac gcaccctcgc cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc     5640

gatccggacc gccacatcga gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc     5700

gggctcgaca tcggcaaggt gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc     5760

acgccggaga gcgtcgaagc gggggcggtg ttcgccgaga tcggcccgcg catggccgag     5820

ttgagcggtt cccggctggc cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg     5880

cccaaggagc ccgcgtggtt cctggccacc gtcggcgtct cgcccgacca ccagggcaag     5940

ggtctgggca gcgccgtcgt gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc     6000

gccttcctgg agacctccgc gccccgcaac ctccccttct acgagcggct cggcttcacc     6060

gtcaccgccg acgtcgaggt gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc     6120

ggtgcctgag gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt     6180

tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct     6240

ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta     6300

actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg     6360

tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg     6420

gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat aacttgcaaa     6480

gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata     6540

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg     6600

tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact     6660

ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     6720

atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag     6780

tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt     6840

acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc     6900

aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc     6960

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta     7020

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     7080

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     7140

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     7200

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     7260

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     7320

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     7380

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     7440

acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc     7500

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     7560

ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc     7620

ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt     7680

gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct     7740

caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac     7800

ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact     7860

cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa     7920

gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga     7980

taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt     8040

tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga     8100

agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg     8160

caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat     8220

ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat     8280

tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc     8340

agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga     8400

tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc     8460

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag     8520

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     8580

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     8640

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     8700

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     8760

accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     8820

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     8880

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     8940

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     9000

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagagagaa aggcggacag     9060

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     9120

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     9180

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     9240

gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc     9300

tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac     9360

cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct     9420

ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc     9480

gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt     9540

acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac     9600

aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca     9660

aaagctggag ctgcaagctt                                                 9680


<210>  6
<211>  9652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc atgctgcttc tcgtaacgtc     3180

cttgttgttg tgcgaattgc ctcatccagc attcttgctt attcccaact gggtcaacgt     3240

aataagtgac ttgaaaaaaa tcgaggatct gatacagagt atgcacatcg atgcaacact     3300

ctacactgag agtgatgttc acccgagttg taaagtgaca gcgatgaaat gttttcttct     3360

tgaacttcag gttatatcac ttgaatcagg tgatgctagt atccatgaca cggtggagaa     3420

tctcatcatt cttgctaata acagtctctc ctcaaatggt aatgtaacag aatctggctg     3480

taaagaatgc gaggaattgg aggagaagaa cataaaggaa tttctccaga gcttcgtcca     3540

tatagtacag atgttcatca acacatccga gtctaaatac ggcccgccgt gtccaccgtg     3600

tccagcgcca gagtttctcg gtggcccttc tgtgttcctg ttccccccca agcccaaaga     3660

tacccttatg atatcaagaa caccagaagt cacttgtgtc gttgtcgatg tgagccaaga     3720

agaccctgag gtacagttca actggtatgt agatggggtt gaggttcata acgccaaaac     3780

taagcccaga gaagaacaat tcaatagtac ttatagagtt gtctcagtac ttacggtctt     3840

gcatcaagat tggttgaatg gtaaggaata taagtgcaaa gtgtccaata agggcctgcc     3900

aagcagtata gagaagacta tctccaaggc aaaagggcaa ccccgcgaac cacaggtcta     3960

tactcttcca cccagccaag aggaaatgac taaaaatcaa gtatctctta cgtgccttgt     4020

gaaaggtttt tacccgagtg atattgccgt agagtgggaa tccaacggcc agccagagaa     4080

caactataag actacgccgc cggttttgga tagtgacggc tccttctttc tgtactccag     4140

gctcacggtc gacaagagtc gatggcaaga ggggaacgta tttagttgct ctgtgatgca     4200

tgaagcgctg cacaatcatt atactcagaa gagtctgtcc ctgagtctcg gcaaaatggc     4260

cctgattgta ctgggagggg ttgctggact tctcctgttt atcggactcg gtatcttctt     4320

ctgaacccag ctttcttgta caaagtggtg ataatcgaat tccgataatc aacctctgga     4380

ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg     4440

tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt     4500

ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag     4560

gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc     4620

caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga     4680

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     4740

ttccgtggtg ttgtcgggga agctgacgtc ctttccatgg ctgctcgcct gtgttgccac     4800

ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct     4860

tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca     4920

gacgagtcgg atctcccttt gggccgcctc cccgcatcgg gaattcccgc ggttcgaatt     4980

ctaccgggta ggggaggcgc ttttcccaag gcagtctgga gcatgcgctt tagcagcccc     5040

gctgggcact tggcgctaca caagtggcct ctggcctcgc acacattcca catccaccgg     5100

taggcgccaa ccggctccgt tctttggtgg ccccttcgcg ccaccttcta ctcctcccct     5160

agtcaggaag ttcccccccg ccccgcagct cgcgtcgtgc aggacgtgac aaatggaagt     5220

agcacgtctc actagtctcg tgcagatgga cagcaccgct gagcaatgga agcgggtagg     5280

cctttggggc agcggccaat agcagctttg ctccttcgct ttctgggctc agaggctggg     5340

aaggggtggg tccgggggcg ggctcagggg cgggctcagg ggcggggcgg gcgcccgaag     5400

gtcctccgga ggcccggcat tctgcacgct tcaaaagcgc acgtctgccg cgctgttctc     5460

ctcttcctca tctccgggcc tttcgacctc acgtggccac catgaccgag tacaagccca     5520

cggtgcgcct cgccacccgc gacgacgtcc ccagggccgt acgcaccctc gccgccgcgt     5580

tcgccgacta ccccgccacg cgccacaccg tcgatccgga ccgccacatc gagcgggtca     5640

ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag gtgtgggtcg     5700

cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa gcgggggcgg     5760

tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg gccgcgcagc     5820

aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg ttcctggcca     5880

ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc gtgctccccg     5940

gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc gcgccccgca     6000

acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag gtgcccgaag     6060

gaccgcgcac ctggtgcatg acccgcaagc ccggtgcctg aggtaccttt aagaccaatg     6120

acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg actggaaggg     6180

ctaattcact cccaacgaag acaagatctg ctttttgctt gtactgggtc tctctggtta     6240

gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa     6300

taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac     6360

tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtag tagttcatgt     6420

catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag tgagaggaac     6480

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat     6540

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat     6600

catgtctggc tctagctatc ccgcccctaa ctccgcccat cccgccccta actccgccca     6660

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     6720

ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggga     6780

cgtacccaat tcgccctata gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca     6840

acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc     6900

tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg     6960

cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt     7020

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt     7080

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct     7140

ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg     7200

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga     7260

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc     7320

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga     7380

gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaggt     7440

ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca     7500

aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg     7560

aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc     7620

cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg     7680

ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt     7740

cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta     7800

ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat     7860

gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga     7920

gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca     7980

acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact     8040

cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc     8100

acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact     8160

ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt     8220

ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt     8280

gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt     8340

atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata     8400

ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag     8460

attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat     8520

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     8580

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     8640

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     8700

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg     8760

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     8820

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     8880

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     8940

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     9000

gccacgcttc ccgaagagag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     9060

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     9120

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     9180

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     9240

cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag     9300

tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa     9360

gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc     9420

agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg     9480

agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg     9540

tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc     9600

aagcgcgcaa ttaaccctca ctaaagggaa caaaagctgg agctgcaagc tt             9652


<210>  7
<211>  10907
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg ctcttgctcg     3180

tcacctcctt gctgctgtgt gaactgccgc accctgcgtt ccttcttatt ccacaggacc     3240

gacacatgat ccgaatgcgc caactcatag acatcgtaga ccagctcaag aattatgtca     3300

acgacctggt gcctgagttc ctcccggctc cagaggacgt cgaaacaaac tgcgaatggt     3360

ctgcttttag ctgttttcaa aaggcgcagt tgaaatcagc gaacacgggc aataatgagc     3420

gcattattaa cgtctcaatc aagaaactga aaagaaagcc accgtcaaca aatgctgggc     3480

gacggcagaa acatagactt acctgcccaa gctgtgactc ctacgagaaa aagccgccga     3540

aagagtttct tgaaaggttc aagagcctcc tccagaaggt gtctaccctg agcttcatcg     3600

aatccaagta cggtccccca tgtcccccgt gccccgcccc tgagtttctg gggggtcctt     3660

cagtttttct gttcccgcca aagccaaagg acactctgat gatatccaga acaccggagg     3720

ttacttgtgt cgtggtcgat gttagccaag aggaccccga agttcagttc aactggtatg     3780

tcgacggcgt ggaagtccat aatgcaaaaa cgaaaccacg ggaagagcaa ttcaatagca     3840

cctacagagt agtatcagtt ctgaccgttc tgcatcaaga ctggctcaac ggtaaagaat     3900

acaagtgcaa agtgtctaat aaaggcttgc ctagttccat agaaaagacc atcagcaagg     3960

cgaaagggca accacgagag ccacaagtct atacgcttcc cccatcacaa gaagaaatga     4020

cgaagaacca agtgagcttg acgtgcttgg tgaagggttt ttacccgtca gacatagccg     4080

tcgagtggga atcaaatggc cagcccgaga acaattacaa aacaactcca cccgttctcg     4140

actccgacgg ttcctttttc ctctactcac gattgactgt agataagagc agatggcaag     4200

agggaaatgt gttctcttgt agcgtgatgc acgaagcact ccataaccac tacactcaga     4260

aatcactctc tctcagtctt gggaaaatgg cactcattgt gctcggtggg gtggcaggtc     4320

ttcttctgtt tattggcctt ggaatatttt tcggaagcgg agagggcagg ggaagtcttc     4380

taacatgcgg ggacgtggag gaaaatcccg gccccatgct gcttctcgta acgtccttgt     4440

tgttgtgcga attgcctcat ccagcattct tgcttattcc caactgggtc aacgtaataa     4500

gtgacttgaa aaaaatcgag gatctgatac agagtatgca catcgatgca acactctaca     4560

ctgagagtga tgttcacccg agttgtaaag tgacagcgat gaaatgtttt cttcttgaac     4620

ttcaggttat atcacttgaa tcaggtgatg ctagtatcca tgacacggtg gagaatctca     4680

tcattcttgc taataacagt ctctcctcaa atggtaatgt aacagaatct ggctgtaaag     4740

aatgcgagga attggaggag aagaacataa aggaatttct ccagagcttc gtccatatag     4800

tacagatgtt catcaacaca tccgagtcta aatacggccc gccgtgtcca ccgtgtccag     4860

cgccagagtt tctcggtggc ccttctgtgt tcctgttccc ccccaagccc aaagataccc     4920

ttatgatatc aagaacacca gaagtcactt gtgtcgttgt cgatgtgagc caagaagacc     4980

ctgaggtaca gttcaactgg tatgtagatg gggttgaggt tcataacgcc aaaactaagc     5040

ccagagaaga acaattcaat agtacttata gagttgtctc agtacttacg gtcttgcatc     5100

aagattggtt gaatggtaag gaatataagt gcaaagtgtc caataagggc ctgccaagca     5160

gtatagagaa gactatctcc aaggcaaaag ggcaaccccg cgaaccacag gtctatactc     5220

ttccacccag ccaagaggaa atgactaaaa atcaagtatc tcttacgtgc cttgtgaaag     5280

gtttttaccc gagtgatatt gccgtagagt gggaatccaa cggccagcca gagaacaact     5340

ataagactac gccgccggtt ttggatagtg acggctcctt ctttctgtac tccaggctca     5400

cggtcgacaa gagtcgatgg caagagggga acgtatttag ttgctctgtg atgcatgaag     5460

cgctgcacaa tcattatact cagaagagtc tgtccctgag tctcggcaaa atggccctga     5520

ttgtactggg aggggttgct ggacttctcc tgtttatcgg actcggtatc ttcttctgaa     5580

cccagctttc ttgtacaaag tggtgataat cgaattccga taatcaacct ctggattaca     5640

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     5700

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     5760

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     5820

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     5880

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     5940

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     6000

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     6060

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     6120

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     6180

gtcggatctc cctttgggcc gcctccccgc atcgggaatt cccgcggttc gaattctacc     6240

gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca gccccgctgg     6300

gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc accggtaggc     6360

gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct cccctagtca     6420

ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac     6480

gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg gtaggccttt     6540

ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg ctgggaaggg     6600

gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct     6660

ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt     6720

cctcatctcc gggcctttcg acctcacgtg gccaccatga ccgagtacaa gcccacggtg     6780

cgcctcgcca cccgcgacga cgtccccagg gccgtacgca ccctcgccgc cgcgttcgcc     6840

gactaccccg ccacgcgcca caccgtcgat ccggaccgcc acatcgagcg ggtcaccgag     6900

ctgcaagaac tcttcctcac gcgcgtcggg ctcgacatcg gcaaggtgtg ggtcgcggac     6960

gacggcgccg cggtggcggt ctggaccacg ccggagagcg tcgaagcggg ggcggtgttc     7020

gccgagatcg gcccgcgcat ggccgagttg agcggttccc ggctggccgc gcagcaacag     7080

atggaaggcc tcctggcgcc gcaccggccc aaggagcccg cgtggttcct ggccaccgtc     7140

ggcgtctcgc ccgaccacca gggcaagggt ctgggcagcg ccgtcgtgct ccccggagtg     7200

gaggcggccg agcgcgccgg ggtgcccgcc ttcctggaga cctccgcgcc ccgcaacctc     7260

cccttctacg agcggctcgg cttcaccgtc accgccgacg tcgaggtgcc cgaaggaccg     7320

cgcacctggt gcatgacccg caagcccggt gcctgaggta cctttaagac caatgactta     7380

caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat     7440

tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct ggttagacca     7500

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     7560

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     7620

atccctcaga cccttttagt cagtgtggaa aatctctagc agtagtagtt catgtcatct     7680

tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt     7740

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     7800

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     7860

ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc     7920

gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc     7980

tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct agggacgtac     8040

ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc     8100

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     8160

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     8220

tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     8280

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     8340

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     8400

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     8460

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     8520

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     8580

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     8640

tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac     8700

ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat     8760

gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag     8820

tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc     8880

tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc     8940

acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc     9000

cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc     9060

ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt     9120

ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt     9180

atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat     9240

cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct     9300

tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat     9360

gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc     9420

ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg     9480

ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc     9540

tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta     9600

cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc     9660

ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga     9720

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     9780

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     9840

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     9900

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     9960

ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt    10020

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt    10080

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata    10140

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt    10200

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac    10260

gcttcccgaa gagagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga    10320

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg    10380

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa    10440

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat    10500

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc    10560

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga    10620

agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg    10680

gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta    10740

gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg    10800

aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg    10860

cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagctt                  10907


