                               SEQUENCE LISTING

<110>  BAND THERAPEUTICS, LLC
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF COMPLICATIONS AND 
       DISORDERS RELATING TO VON WILLEBRAND FACTOR

<130>  2059.1002PCT

<140>  PCT/US2018/XXXXXX
<141>  2018-05-18

<150>  62/508,530
<151>  2017-05-19

<150>  62/638,579
<151>  2018-03-05

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
gccagggacc uaagacacau gucccuggc                                         29


<210> 2
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(29)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> Inverted nucleotide

<400> 2
gccagggacc uaagacacau gucccuggct                                        30


<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(29)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> Inverted nucleotide

<400> 3
gccagggacc uaagacacau gucccuggct                                        30


<210> 4
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
acaugugucu uaggucccug gc                                                22


<210> 5
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(22)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> Inverted nucleotide

<400> 5
acaugugucu uaggucccug gct                                               23


<210> 6
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(21)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (22)..(22)
<223> Inverted nucleotide

<400> 6
gggaccuaag acacaugucc ct                                                22


<210> 7
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(18)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (27)..(28)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (30)..(30)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (33)..(34)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (36)..(39)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (40)..(40)
<223> Inverted nucleotide

<400> 7
gcgugcagug ccuucggccg tgcggtgccu ccgucacgct                             40


<210> 8
<211> 8833
<212> DNA
<213> Homo sapiens

<400> 8
agctcacagc tattgtggtg ggaaagggag ggtggttggt ggatgtcaca gcttgggctt       60

tatctccccc agcagtgggg actccacagc ccctgggcta cataacagca agacagtccg      120

gagctgtagc agacctgatt gagcctttgc agcagctgag agcatggcct agggtgggcg      180

gcaccattgt ccagcagctg agtttcccag ggaccttgga gatagccgca gccctcattt      240

gcaggggaag atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt      300

gccagggacc ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct      360

tttcggaagt gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg      420

cagttacctc ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca      480

gaatggcaag agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt      540

tgtcaatggt accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg      600

gctgtatcta gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt      660

ggccaggatc gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa      720

gacctgcggg ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga      780

agggaccttg acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga      840

acagtggtgt gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat      900

gcagaagggc ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg      960

ccaccctctg gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg     1020

tgctgggggg ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca     1080

ggagggaatg gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc     1140

tggtatggag tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat     1200

caatgaaatg tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct     1260

ggatgaaggc ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta     1320

ccctcccggc acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg     1380

gatctgcagc aatgaagaat gtccagggga gtgccttgtc acaggtcaat cacacttcaa     1440

gagctttgac aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga     1500

ttgccaggac cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga     1560

cgctgtgtgc acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa     1620

actgaagcat ggggcaggag ttgccatgga tggccaggac gtccagctcc ccctcctgaa     1680

aggtgacctc cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga     1740

cctgcagatg gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc     1800

cgggaagacc tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac     1860

cccctctggg ctggcggagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg     1920

ggactgccag gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac     1980

caggttctcc gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg     2040

tgccgtcagc ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga     2100

cggccgcgag tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg     2160

cgtgcgcgtc gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt     2220

gtacctgcag tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga     2280

ggaatgcaat gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga     2340

gaggggggac tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca     2400

gccagaagac atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca     2460

ctgtaccatg agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct     2520

gtctcatcgc agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc     2580

cgctgacaac ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct     2640

ggagtgcatg agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca     2700

tgagaacaga tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc     2760

ccctggagaa acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa     2820

ctgcacagac catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac     2880

cttcgacggg ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta     2940

ctgcggcagt aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc     3000

ctcagtgaaa tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt     3060

tgacggggag gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga     3120

gtctggccgg tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca     3180

cctgagcatc tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg     3240

gaattttgat ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga     3300

ccctgtggac tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt     3360

gcctctggac tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga     3420

ttcctcctgt agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc     3480

cgagccatat ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg     3540

cgcctgcttc tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt     3600

ggtgacctgg aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga     3660

gaacgggtat gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg     3720

tcagcaccct gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg     3780

ccctccaggg aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc     3840

agtgtgtgag gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag     3900

tgaccctgag cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg     3960

ccaggagccg ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct     4020

gtatgtggag gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga     4080

cctggtcttc ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa     4140

ggcctttgtg gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc     4200

cgtggtggag taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc     4260

gtcagagctg cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac     4320

cagcgaggtc ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc     4380

ctcccgcatc accctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt     4440

tgtccgctac gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg     4500

gccccatgcc aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc     4560

cttcgtgctg agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct     4620

ctgtgacctt gcccctgaag cccctcctcc tactctgccc cccgacatgg cacaagtcac     4680

tgtgggcccg gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct     4740

ggatgtggcg ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag     4800

caaggagttc atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt     4860

cacggtgctg cagtactcct acatggtgac tgtggagtac cccttcagcg aggcacagtc     4920

caaaggggac atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa     4980

cactgggctg gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg     5040

ggagcaggcg cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa     5100

gaggctgcct ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca     5160

ggagctggag aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct     5220

cccccgagag gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat     5280

ccccaccctc tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga     5340

tggctcctcc agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt     5400

catttcaaaa gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag     5460

catcaccacc attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct     5520

tgtggacgtc atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc     5580

tgtgcgatac ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt     5640

catcctggtc acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc     5700

caacagagtg acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg     5760

gatcttggca ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct     5820

ccctaccatg gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag     5880

gatttgcatg gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga     5940

ccagtgccac accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt     6000

caactgtgac cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga     6060

agagacctgt ggctgccgct ggacctgccc ctgcgtgtgc acaggcagct ccactcggca     6120

catcgtgacc tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt     6180

tcaaaacaag gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc     6240

aaggcagggc tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagctgca     6300

cagtgacatg gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa     6360

catggaagtc aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca     6420

catcttcaca ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt     6480

tgcttcaaag acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat     6540

gctgagggat ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca     6600

gcggccaggg cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc     6660

ccactgccag gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc     6720

cacattctat gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat     6780

cgcctcttat gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga     6840

tttctgtgct atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc     6900

ccggcactgt gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg     6960

ccctccagat aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg     7020

cattggtgag gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc     7080

ctgtcagatc tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc     7140

cacggccaaa gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga     7200

ccagtgctgc cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt     7260

gcctcactgt gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa     7320

cttcacctgc gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc     7380

gcaccgtttg cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa     7440

ctgtgtcaac tccacagtga gctgtcccct tgggtacttg gcctcaactg ccaccaatga     7500

ctgtggctgt accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat     7560

ctaccctgtg ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga     7620

ggatgccgtg atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg     7680

tcggtcgggc ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc     7740

tgcctgtgag gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt     7800

cggctcccag tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa     7860

ggaggaggtc tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg     7920

cccctcgggc tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga     7980

gcgcatggag gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat     8040

cgatgtgtgc acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct     8100

ggagtgcagg aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac     8160

aggtgaatgt tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca     8220

gatcatgaca ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa     8280

ggtcaatgag agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga     8340

tgaacacaag tgtctggctg agggaggtaa aattatgaaa attccaggca cctgctgtga     8400

cacatgtgag gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg     8460

aagctgtaag tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa     8520

agccatgtac tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac     8580

acggacggag cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga     8640

ggttctcaat gccatggagt gcaaatgctc ccccaggaag tgcagcaagt gaggctgctg     8700

cagctgcatg ggtgcctgct gctgcctgcc ttggcctgat ggccaggcca gagtgctgcc     8760

agtcctctgc atgttctgct cttgtgccct tctgagccca caataaaggc tgagctctta     8820

tcttgcaaaa ggc                                                        8833


<210> 9
<211> 2813
<212> PRT
<213> Homo sapiens

<400> 9
Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210> 10
<211> 10
<212> PRT
<213> Homo sapiens

<400> 10
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 12
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(22)
<223> 2'-O-Methyl nucleotide

<400> 12
acaugugucu uaggucccug gc                                                22


