                         SEQUENCE LISTING

<110>  Yale University
       Sessa, William
       Kraehling, Jan
 
<120>  Compounds and Compositions that Inhibit or Prevent Lipoprotein 
       Entry into the Endothelium

<130>  047162-7127WO1(00708)

<150>  62/507,452
<151>  2017-05-17

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  2
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Asp Pro Val Lys Pro Ser Arg Gly 
            20                  25                  30          


Pro Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr 
        35                  40                  45              


Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg 
    50                  55                  60                  


His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His 
                85                  90                  95      


Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro 
            100                 105                 110         


Ser Glu Gln Pro Gly Thr Asp Gly Gln Leu Ala Thr Gly Gly Gly Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser Val Phe Leu Phe 
        355                 360                 365             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    370                 375                 380                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
385                 390                 395                 400 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                405                 410                 415     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            420                 425                 430         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        435                 440                 445             


Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    450                 455                 460                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
465                 470                 475                 480 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                485                 490                 495     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            500                 505                 510         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Pro 
        515                 520                 525             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    530                 535                 540                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
545                 550                 555                 560 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                565                 570                 575     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Pro 
            580                 585                 590         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        595                 600                 605             


<210>  3
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Asp Pro Val Lys Pro Ser Arg Gly 
            20                  25                  30          


Pro Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr 
        35                  40                  45              


Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg 
    50                  55                  60                  


His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Ala Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His 
                85                  90                  95      


Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro 
            100                 105                 110         


Ser Glu Gln Pro Gly Thr Asp Gly Gln Leu Ala Thr Gly Gly Gly Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg 
            260 


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Asp Asp Cys Thr Gly Asp Glu Asp 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Lys Arg Gly Leu Lys Leu Ala Thr 
1               5                   


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

His Arg Asp Phe Ser Ala Glu Tyr Glu Glu Asp 
1               5                   10      


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Gln Ile Gln Asp Asp Cys Thr Gly Asp Glu Asp Tyr Thr Tyr 
1               5                   10                  15  


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Gln Asp Asp Cys Thr Gly Asp Glu Asp Tyr Thr Tyr Leu Ile Leu 
1               5                   10                  15      


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Asp Asp Cys Thr Gly Asp Glu Asp 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Phe Ile Ile Pro Ser Pro Lys 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Lys Ala Gln Tyr Lys Lys Asn Lys 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Lys Arg Gly Leu Lys Leu Ala Thr 
1               5                   


<210>  13
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Ser Val Lys Ala Gln Tyr Lys Lys Asn Lys His Arg His Ser Ile 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Ile Leu Lys Thr Ser Gln Cys Thr Leu Lys Glu Val Tyr Gly 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp Leu Gly Gln 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Thr Tyr Leu Val Ala Leu Ile Pro Glu Pro Ser Ala Gln Gln 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile Gln Ala Leu Arg 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Val Leu Val Asp His Phe Gly Tyr Thr Lys Asp Asp Lys His 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile Ser Ser Ser Gly Val 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Tyr Asn Arg Gln Ser Met Thr Leu Ser Ser Glu Val Gln Ile Pro 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Val Ser Lys Arg Val Ala Trp His Tyr Asp Glu Glu Lys Ile 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Leu Pro Asp Phe His Ile Pro Glu Asn Leu Phe Leu Lys Ser 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Gly Gly Asn Thr Ser Thr Asp His Phe Ser Leu Arg Ala Arg 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Lys Glu Val Lys Ile Asp Gly Gln Phe Arg Val Ser Ser Phe 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Met Thr Phe Ser Lys Gln Asn Ala Leu Leu Arg Ser Glu Tyr 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Lys Phe Ser Leu Asp Gly Lys Ala Ala Leu Thr Glu Leu Ser 
1               5                   10                  15  


<210>  30
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  30

Lys Tyr Asn Ala Leu Asp Leu Thr Asn Asn Gly Lys Arg Leu 
1               5                   10                  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala His Thr Asn Gly Asn Gly Lys Leu Ala Leu Trp Gly Glu His 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Leu Thr Leu Leu Asp Ser Pro Ile Lys Val Pro Leu Leu Leu 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Asn Asp Tyr Leu Asn Ser Phe Asn Trp Glu Arg Gln Val Ser His 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

His Leu Phe Ile Glu Asn Ile Asp Phe Asn Lys Ser Gly Ser Ser 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Phe Arg Ala Lys Val His Glu Leu Ile Glu Arg Tyr Glu Val Asp 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Glu Val Thr Gln Arg Leu Asn Gly Glu Ile Gln Ala Leu Glu 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Asp Trp Trp Thr Leu Ala Ala Lys Asn Leu Thr Asp Phe Ala 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Pro Ser Phe Thr Ile Asp Phe Val Glu Met Lys Val Lys Ile 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Ser Pro Leu Phe Thr Leu Asp Ala Asn Ala Asp Ile Gly Asn 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Val Ile Val Lys Ile Asn Asn Gln Leu Thr Leu Asp Ser Asn 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Ser Leu Asn Phe Ser Lys Leu Glu Ile Gln Ser Gln Val Asp 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Trp Gln Val Ser Ala Arg Phe Asn Gln Tyr Lys Tyr Asn Gln 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Cys Glu Phe Ile Ser Gln Ser Ile Lys Ser Phe Asp Arg His 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Pro Ser Leu Glu Leu Pro Val Leu His Val Pro Arg Asn Leu Lys 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Gly Ser His Asn Ser Thr Val Ser Leu Thr Thr Lys Asn Met 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Ser Glu Ala Asn Thr Tyr Leu Asn Ser Lys Ser Thr Arg Ser 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Leu Asn Ala Asn Thr Lys Asn Gln Lys Ile Arg Trp Lys Asn 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Lys Phe Ile Ile Pro Gly Leu Lys Leu Asn Asp Leu Asn Ser 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  49

Ile Ala Ala Leu Asp Leu Asn Ala Val Ala Asn Lys Ile Ala Asp 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Ser Lys Thr Lys Gly Thr Phe Ala His Arg Asp Phe Ser Ala 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Glu Glu Thr Gln Ile Lys Val Asn Trp Glu Glu Glu Ala Ala 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  52

Leu Thr Gln Glu Gly Gln Ala Ser Phe Gln Gly Leu Lys Asp Asn 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Asp Val Ile Ser Met Tyr Arg Glu Leu Leu Lys Asp Leu Ser 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Ser Gln Glu Leu Gln Gln Ile His Gln Tyr Ile Met Ala Leu 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  55

Ile Lys Ser Gln Ala Ile Ala Thr Lys Lys Ile Ile Ser Asp Tyr 
1               5                   10                  15  


