                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> INHIBITING THE FUNGAL CELL-SURFACE PHOSPHATE TRANSPORTER PHO84

<130> 368665-1009WO1(00016)

<140> PCT/US2018/032992
<141> 2018-05-16

<150> 62/509,593
<151> 2017-05-22

<150> 62/506,897
<151> 2017-05-16

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 1717
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
caaaaaatct aataattaca aaacttgtaa agcataaaac taaaaacttt ttattaataa       60

aaagaaatat ctcgtttgta tgttaaattg ttgtacacat gggcaattac ttggattggc      120

taaacgaaat aataaaaatg ttgccattct agttttaaat actttatgat tttagatgca      180

ttattacatt tcgatttagt catgtaaatg attagtgtac catgtttggt tggtaattgc      240

ctccccattc aagataacta cactcatgtc ttacccagac ctccctatat gccactccaa      300

actatccaac ccttatagag atcacccttt taatcctcca attcatagat tattaacctt      360

gacatagcta ccagatataa aatattcaaa ttttttttgt tctcaacttc actctattct      420

ccatttttta cagtttacag gaacattccc aaaagaagca aaaaaaaata aaaattgtaa      480

gacttgaatt acacaaaata aattatagtt tttttttttg cactaaaatt caatttacac      540

aaaatttaat aatttctgaa aagtatcagt atcatcatca ccaagaaaac gcagccttca      600

aataaaaact cattttaatt aaaactctct tatgaaatta aattcatccc taatagaaag      660

gaaaggaaaa aaaaaaaaag aaatctcttg catatctcgt tatatatttt gtatgaaata      720

atataataaa tatatacttc aaattagaat atataaatat ttaaaacaat tcccttaaat      780

tattgaaatt tttatttttt tataattctt cttcttcttt tctttaagga ctatttcaat      840

atctcaattg ttatttcact ttattttcct tcatatttac ttattcattg ggtttcctgc      900

gtatatacat accctccccc ctctttttgc tatatcacat ttacaactaa cactatagtt      960

tttacaaaaa gatggttgct gaaattcaar sctcacacta atggtgagca agggcgagga     1020

gctgttcacc ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa     1080

gttcagcgtg tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt     1140

catctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta     1200

cggcgtgcag tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc     1260

cgccatgccc gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta     1320

caagacccgc gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa     1380

gggcatcgac ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa     1440

cagccacaac gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa     1500

gatccgccac aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac     1560

ccccatcggc gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc     1620

cctgagcaaa gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc     1680

cgccgggatc actctcggca tggacgagct gtacaag                              1717


<210> 2
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210> 3
<211> 545
<212> PRT
<213> Candida albicans


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<400> 3
Met Lys Tyr Pro Lys Val Xaa Gly Lys Thr Ala Phe Lys Asp Tyr Leu 
1               5                   10                  15      


Gly Lys Phe Ala Asp Val Glu Asp Pro Leu Glu Arg Arg Arg Leu Ala 
            20                  25                  30          


Leu Glu Glu Ile Asp Lys Ala Gly Phe Gly Trp Thr Gln Val Lys Met 
        35                  40                  45              


Ile Leu Ile Ala Gly Val Gly Phe Met Thr Asp Ser Tyr Asp Ile Phe 
    50                  55                  60                  


Ala Ile Asn Leu Ser Met Asn Met Leu Gln Tyr Val Tyr Trp Asn Gly 
65                  70                  75                  80  


Thr Ile Pro Asp Ser Thr Thr Thr Leu Ile Lys Val Ser Thr Ser Val 
                85                  90                  95      


Gly Thr Val Ile Gly Gln Ile Ser Phe Gly Ser Ile Ala Asp Lys Val 
            100                 105                 110         


Gly Arg Lys Lys Ile Tyr Gly Leu Glu Leu Ile Ile Met Ile Phe Ala 
        115                 120                 125             


Thr Leu Phe Gln Cys Thr Leu Gly Thr Ser Pro Ala Ile Asn Phe Val 
    130                 135                 140                 


Ala Ile Phe Ser Thr Ile Arg Ile Leu Met Gly Ile Gly Ile Gly Gly 
145                 150                 155                 160 


Asp Tyr Pro Leu Ser Ser Ile Ile Ser Ser Glu Phe Ser Thr Thr Lys 
                165                 170                 175     


Trp Arg Gly Ala Ile Met Ala Ala Val Phe Ser Asn Gln Gly Leu Gly 
            180                 185                 190         


Gln Val Phe Ala Gly Ile Val Ala Met Ile Cys Val Ala Gly Tyr Lys 
        195                 200                 205             


Asp Asp Leu Ile Ile Ala Asn Lys Gly Ser Glu Cys Val Gly Arg Cys 
    210                 215                 220                 


Arg Lys Ala Ala Asp Gln Met Trp Arg Ile Ile Val Gly Phe Gly Cys 
225                 230                 235                 240 


Val Pro Gly Cys Ile Ala Leu Tyr Tyr Arg Leu Thr Ile Ala Glu Ser 
                245                 250                 255     


Pro Arg Tyr Ala Leu Asp Val Asp Glu His Asp Asp Leu Glu Lys Val 
            260                 265                 270         


Ala Asp Ala Glu Ala Ala Ile Asp Val His Ala Gln Glu Ile Ala Pro 
        275                 280                 285             


Pro Lys Ala Ser Phe Lys Asp Phe Cys Ser His Phe Gly Gln Trp Arg 
    290                 295                 300                 


Tyr Gly Lys Ile Leu Leu Gly Thr Ala Gly Ser Trp Phe Met Leu Asp 
305                 310                 315                 320 


Val Ala Tyr Tyr Gly Leu Gly Leu Asn Thr Thr Thr Ile Leu Gln Thr 
                325                 330                 335     


Ile Gly Tyr Ala Gly Gln Ser Asn Val Tyr Glu Lys Leu Tyr Asn Ser 
            340                 345                 350         


Ala Ala Gly Asn Leu Ile Leu Val Cys Ala Gly Ser Leu Pro Gly Tyr 
        355                 360                 365             


Trp Val Ser Ala Ala Thr Ile Asp Thr Val Gly Arg Lys Pro Ile Gln 
    370                 375                 380                 


Met Gly Gly Phe Ile Leu Leu Thr Ile Ile Leu Cys Ile Met Gly Phe 
385                 390                 395                 400 


Gly Tyr His Lys Ile Gly Asn His Gly Leu Leu Gly Leu Phe Val Ile 
                405                 410                 415     


Ala Gln Phe Phe Gln Asn Phe Gly Pro Asn Thr Thr Thr Phe Ile Val 
            420                 425                 430         


Pro Gly Glu Cys Phe Pro Thr Arg Tyr Arg Ser Thr Ala His Gly Leu 
        435                 440                 445             


Ser Ala Ala Ala Gly Lys Val Gly Ala Ile Ile Ala Gln Thr Cys Ile 
    450                 455                 460                 


Gly Thr Leu Val Asn His Gly Cys Ser Lys Glu Asn Lys Asn Cys Phe 
465                 470                 475                 480 


Leu Pro His Val Leu Glu Ile Phe Ala Leu Phe Met Leu Leu Gly Ile 
                485                 490                 495     


Gly Leu Thr Phe Leu Ile Pro Glu Thr Ala Arg Arg Thr Leu Glu Glu 
            500                 505                 510         


Ile Ser Glu Thr Cys His Gly Glu Val Asp Thr Thr Lys Leu Gly Arg 
        515                 520                 525             


Asp Arg Phe Ala Thr Gln Glu Glu Pro Tyr Asp Ser Glu Glu Val Lys 
    530                 535                 540                 


Asn 
545 


<210> 4
<211> 587
<212> PRT
<213> Saccharomyces cerevisiae

<400> 4
Met Ser Ser Val Asn Lys Asp Thr Ile His Val Ala Glu Arg Ser Leu 
1               5                   10                  15      


His Lys Glu His Leu Thr Glu Gly Gly Asn Met Ala Phe His Asn His 
            20                  25                  30          


Leu Asn Asp Phe Ala His Ile Glu Asp Pro Leu Glu Arg Arg Arg Leu 
        35                  40                  45              


Ala Leu Glu Ser Ile Asp Asp Glu Gly Phe Gly Trp Gln Gln Val Lys 
    50                  55                  60                  


Thr Ile Ser Ile Ala Gly Val Gly Phe Leu Thr Asp Ser Tyr Asp Ile 
65                  70                  75                  80  


Phe Ala Ile Asn Leu Gly Ile Thr Met Met Ser Tyr Val Tyr Trp His 
                85                  90                  95      


Gly Ser Met Pro Gly Pro Ser Gln Thr Leu Leu Lys Val Ser Thr Ser 
            100                 105                 110         


Val Gly Thr Val Ile Gly Gln Phe Gly Phe Gly Thr Leu Ala Asp Ile 
        115                 120                 125             


Val Gly Arg Lys Arg Ile Tyr Gly Met Glu Leu Ile Ile Met Ile Val 
    130                 135                 140                 


Cys Thr Ile Leu Gln Thr Thr Val Ala His Ser Pro Ala Ile Asn Phe 
145                 150                 155                 160 


Val Ala Val Leu Thr Phe Tyr Arg Ile Val Met Gly Ile Gly Ile Gly 
                165                 170                 175     


Gly Asp Tyr Pro Leu Ser Ser Ile Ile Thr Ser Glu Phe Ala Thr Thr 
            180                 185                 190         


Lys Trp Arg Gly Ala Ile Met Gly Ala Val Phe Ala Asn Gln Ala Trp 
        195                 200                 205             


Gly Gln Ile Ser Gly Gly Ile Val Ala Leu Ile Leu Val Ala Ala Tyr 
    210                 215                 220                 


Lys Gly Glu Leu Glu Tyr Ala Asn Ser Gly Ala Glu Cys Asp Ala Arg 
225                 230                 235                 240 


Cys Gln Lys Ala Cys Asp Gln Met Trp Arg Ile Leu Ile Gly Leu Gly 
                245                 250                 255     


Thr Val Leu Gly Leu Ala Cys Leu Tyr Phe Arg Leu Thr Ile Pro Glu 
            260                 265                 270         


Ser Pro Arg Tyr Gln Leu Asp Val Asn Ala Lys Leu Glu Leu Ala Ala 
        275                 280                 285             


Ala Ala Gln Glu Gln Asp Gly Glu Lys Lys Ile His Asp Thr Ser Asp 
    290                 295                 300                 


Glu Asp Met Ala Ile Asn Gly Leu Glu Arg Ala Ser Thr Ala Val Glu 
305                 310                 315                 320 


Ser Leu Asp Asn His Pro Pro Lys Ala Ser Phe Lys Asp Phe Cys Arg 
                325                 330                 335     


His Phe Gly Gln Trp Lys Tyr Gly Lys Ile Leu Leu Gly Thr Ala Gly 
            340                 345                 350         


Ser Trp Phe Thr Leu Asp Val Ala Phe Tyr Gly Leu Ser Leu Asn Ser 
        355                 360                 365             


Ala Val Ile Leu Gln Thr Ile Gly Tyr Ala Gly Ser Lys Asn Val Tyr 
    370                 375                 380                 


Lys Lys Leu Tyr Asp Thr Ala Val Gly Asn Leu Ile Leu Ile Cys Ala 
385                 390                 395                 400 


Ser Gly Leu Pro Gly Tyr Trp Cys Ser Val Phe Thr Val Asp Ile Ile 
                405                 410                 415     


Gly Arg Lys Pro Ile Gln Leu Ala Gly Phe Ile Ile Leu Thr Ala Leu 
            420                 425                 430         


Phe Cys Val Ile Gly Phe Ala Tyr His Lys Leu Gly Asp His Gly Leu 
        435                 440                 445             


Leu Ala Leu Tyr Val Ile Cys Gln Phe Phe Gln Asn Phe Gly Pro Asn 
    450                 455                 460                 


Thr Thr Thr Phe Ile Val Pro Gly Glu Cys Phe Pro Thr Arg Tyr Arg 
465                 470                 475                 480 


Ser Thr Ala His Gly Ile Ser Ala Ala Ser Gly Lys Val Gly Ala Ile 
                485                 490                 495     


Ile Ala Gln Thr Ala Leu Gly Thr Leu Ile Asp His Asn Cys Ala Arg 
            500                 505                 510         


Asp Gly Lys Pro Thr Asn Cys Trp Leu Pro His Val Met Glu Ile Phe 
        515                 520                 525             


Ala Leu Phe Met Leu Leu Gly Ile Phe Thr Thr Leu Leu Ile Pro Glu 
    530                 535                 540                 


Thr Lys Arg Lys Thr Leu Glu Glu Ile Asn Glu Leu Tyr His Asp Glu 
545                 550                 555                 560 


Ile Asp Pro Ala Thr Leu Asn Phe Arg Asn Lys Asn Asn Asp Ile Glu 
                565                 570                 575     


Ser Ser Ser Pro Ser Gln Leu Gln His Glu Ala 
            580                 585         


<210> 5
<211> 522
<212> PRT
<213> Piriformospora indica

<400> 5
Met Leu Ala Asp Leu Asp His Phe Gly Lys Asn Tyr Lys His Asp Glu 
1               5                   10                  15      


Glu Ala Gln Arg Asn Gln Lys Pro Trp Met Leu Thr Trp Pro Gln Ile 
            20                  25                  30          


Lys Leu Val Leu Leu Ala Gly Val Gly Phe Phe Leu Asp Ala Tyr Asp 
        35                  40                  45              


Leu Phe Ile Ile Asn Gln Val Ala Pro Met Leu Ala Gln Val Tyr Phe 
    50                  55                  60                  


Pro Lys Thr Gly Leu Pro Ala Gln Arg Gln Asp Leu Met Lys Ala Ala 
65                  70                  75                  80  


Ala Asn Ile Gly Cys Val Val Gly Gln Val Met Phe Gly Val Leu Gly 
                85                  90                  95      


Asp Ser Phe Gly Arg Lys Phe Val Tyr Gly Lys Glu Leu Ile Leu Ile 
            100                 105                 110         


Ile Val Ala Thr Ile Phe Gln Met Ser Ala Pro Ser His Trp Asp Gly 
        115                 120                 125             


Asn Arg Val Leu Thr Trp Ile Thr Ile Cys Arg Val Phe Leu Gly Ile 
    130                 135                 140                 


Gly Ile Gly Gly Asp Tyr Pro Met Ser Ala Thr Val Val Ser Asp Arg 
145                 150                 155                 160 


Ala Asn Ile His Arg Arg Gly Thr Leu Leu Cys Phe Ile Phe Ala Asn 
                165                 170                 175     


Gln Gly Trp Gly Ser Phe Val Gly Ser Leu Val Thr Ile Val Thr Ile 
            180                 185                 190         


Ser Gly Phe Lys His Arg Leu Lys Ser Gly His Thr His Asp Val Asp 
        195                 200                 205             


Lys Ala Trp Arg Ile Leu Ile Gly Leu Ser Leu Ile Pro Ala Phe Gly 
    210                 215                 220                 


Thr Leu Tyr Gln Arg Leu Thr Leu Pro Glu Ser Arg Lys Phe Glu Leu 
225                 230                 235                 240 


Thr Arg Asp Ala Ala Ser Ser Ser Thr Val Ala Ile Asp Lys Lys Asp 
                245                 250                 255     


His Asp Ala Thr His Glu Val Lys Asp Ala Pro Glu Ser Glu Lys Ser 
            260                 265                 270         


Ser Pro Lys Val Thr Pro Ala Asp Ala Ile Asp Asp Asp Arg His Gly 
        275                 280                 285             


Val Ile Ala Ser Lys Lys Ala His Trp Gln Glu Phe Val Ala Tyr Phe 
    290                 295                 300                 


Ser Thr Trp Asn His Phe Arg Asn Leu Leu Gly Ser Met Leu Gly Trp 
305                 310                 315                 320 


Phe Leu Val Asp Ile Ala Phe Tyr Gly Ile Asn Leu Asn Gln Ser Val 
                325                 330                 335     


Val Leu Ala Gln Ile Gly Phe Ala Gly Lys Thr Gly Asp Val Tyr Asp 
            340                 345                 350         


Lys Leu Phe Gln Leu Ala Thr Gly Asn Ile Ile Val Thr Ala Leu Gly 
        355                 360                 365             


Phe Leu Pro Gly Tyr Tyr Phe Thr Leu Phe Leu Ile Asp Ile Val Gly 
    370                 375                 380                 


Arg Lys Lys Leu Gln Phe Met Gly Phe Ile Met Asp Ser Leu Phe Leu 
385                 390                 395                 400 


Ala Ile Leu Ala Gly Glu Ile Asp His Ile Gly Lys Gly Pro Leu Leu 
                405                 410                 415     


Ala Cys Phe Thr Phe Met Gln Phe Phe Phe Asn Phe Gly Ala Asn Thr 
            420                 425                 430         


Thr Thr Phe Ile Val Ala Ala Glu Leu Phe Pro Thr Arg Ile Arg Ala 
        435                 440                 445             


Ser Ala His Gly Ile Ser Ala Ala Ala Gly Lys Cys Gly Ala Ile Leu 
    450                 455                 460                 


Ser Ser Leu Val Phe Asn Gln Leu Lys Ala Lys Ile Gly Thr Ser Ala 
465                 470                 475                 480 


Val Leu Trp Ile Phe Phe Ser Thr Cys Ile Leu Gly Phe Ile Ser Thr 
                485                 490                 495     


Phe Leu Ile Asp Glu Thr Met Gly Val Asp Pro Asp Glu Lys Asp Leu 
            500                 505                 510         


Glu Glu Arg Arg Ala Arg Gly Glu Ile Pro 
        515                 520         


<210> 6
<211> 265
<212> PRT
<213> Candida albicans


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<400> 6
Met Lys Tyr Pro Lys Val Xaa Gly Lys Thr Ala Phe Lys Asp Tyr Leu 
1               5                   10                  15      


Gly Lys Phe Ala Asp Val Glu Asp Pro Leu Glu Arg Arg Arg Leu Ala 
            20                  25                  30          


Leu Glu Glu Ile Asp Lys Ala Gly Phe Gly Trp Thr Gln Val Lys Met 
        35                  40                  45              


Ile Leu Ile Ala Gly Val Gly Phe Met Thr Asp Ser Tyr Asp Ile Phe 
    50                  55                  60                  


Ala Ile Asn Leu Ser Met Asn Met Leu Gln Tyr Val Tyr Trp Asn Gly 
65                  70                  75                  80  


Thr Ile Pro Asp Ser Thr Thr Thr Leu Ile Lys Val Ser Thr Ser Val 
                85                  90                  95      


Gly Thr Val Ile Gly Gln Ile Ser Phe Gly Ser Ile Ala Asp Lys Val 
            100                 105                 110         


Gly Arg Lys Lys Ile Tyr Gly Leu Glu Leu Ile Ile Met Ile Phe Ala 
        115                 120                 125             


Thr Leu Phe Gln Cys Thr Leu Gly Thr Ser Pro Ala Ile Asn Phe Val 
    130                 135                 140                 


Ala Ile Phe Ser Thr Ile Arg Ile Leu Met Gly Ile Gly Ile Gly Gly 
145                 150                 155                 160 


Asp Tyr Pro Leu Ser Ser Ile Ile Ser Ser Glu Phe Ser Thr Thr Lys 
                165                 170                 175     


Trp Arg Gly Ala Ile Met Ala Ala Val Phe Ser Asn Gln Gly Leu Gly 
            180                 185                 190         


Gln Val Phe Ala Gly Ile Val Ala Met Ile Cys Val Ala Gly Tyr Lys 
        195                 200                 205             


Asp Asp Leu Ile Ile Ala Asn Lys Gly Ser Glu Cys Val Gly Arg Cys 
    210                 215                 220                 


Arg Lys Ala Ala Asp Gln Met Trp Arg Ile Ile Val Gly Phe Gly Cys 
225                 230                 235                 240 


Val Pro Gly Cys Ile Ala Leu Tyr Tyr Arg Leu Thr Ile Ala Glu Ser 
                245                 250                 255     


Pro Arg Tyr Ala Leu Asp Val Asp Glu 
            260                 265 


<210> 7
<211> 279
<212> PRT
<213> Candida parapsilosis

<400> 7
Met Ser Ser Ser Ser Asp Ile Glu Gln Gly His Ile His Thr Ala Lys 
1               5                   10                  15      


Val Ser Gln Ser Gly Gly Lys Thr Ala Phe Lys Asp Tyr Leu Gly Lys 
            20                  25                  30          


Phe Ala Asp Val Glu Asp Pro Leu Glu Arg Arg Arg Leu Ala Leu Glu 
        35                  40                  45              


Glu Ile Asp Lys Ala Gly Phe Gly Trp Thr Gln Val Lys Met Ile Met 
    50                  55                  60                  


Ile Ala Gly Val Gly Phe Met Thr Asp Ser Tyr Asp Ile Phe Ala Ile 
65                  70                  75                  80  


Asn Leu Ser Val Asn Phe Leu Gln Trp Val Tyr Trp Asn Gly Thr Ile 
                85                  90                  95      


Pro Asp Ser Thr Asn Thr Leu Ile Lys Val Ala Thr Ser Val Gly Thr 
            100                 105                 110         


Val Ile Gly Gln Val Gly Phe Gly Thr Val Ala Asp Ile Val Gly Arg 
        115                 120                 125             


Lys Lys Ile Tyr Gly Leu Glu Leu Ala Ile Met Ile Phe Ala Thr Ile 
    130                 135                 140                 


Ala Gln Val Val Leu Gly Glu Ser Pro Ala Ile Asn Phe Val Ala Ile 
145                 150                 155                 160 


Phe Ser Ser Leu Arg Ile Leu Met Gly Ile Gly Ile Gly Gly Asp Tyr 
                165                 170                 175     


Pro Leu Ser Ser Ile Ile Ser Ser Glu Phe Ser Thr Thr Lys Trp Arg 
            180                 185                 190         


Gly Ala Ile Met Ala Ala Val Phe Ser Asn Gln Gly Leu Gly Gln Ile 
        195                 200                 205             


Phe Ala Gly Val Val Ala Met Ile Cys Val Ala Gly Tyr Lys Asn Asp 
    210                 215                 220                 


Leu Ile Asp Tyr Thr Lys Asp Thr Gly Cys His Gly Pro Cys Val Lys 
225                 230                 235                 240 


Ala Cys Asp Gln Met Trp Arg Ile Val Ile Gly Phe Gly Cys Val Pro 
                245                 250                 255     


Gly Cys Ile Ala Leu Tyr Tyr Arg Leu Thr Ile Ala Glu Ser Pro Arg 
            260                 265                 270         


Tyr Thr Leu Asp Met Asp Glu 
        275                 


<210> 8
<211> 290
<212> PRT
<213> Candida lusitaniae

<400> 8
Met Val Asn Val Arg Arg Asn Phe Ser Tyr Phe Ser Ser Ala Pro Val 
1               5                   10                  15      


Ile Pro Met Ser Glu Ile Gln Ala Pro His Glu Val Ser Asn Ser Gly 
            20                  25                  30          


Gly Lys Thr Ala Phe Lys Asp Tyr Val Gly Lys Phe Ala His Ile Glu 
        35                  40                  45              


Asp Pro Leu Glu Arg Arg Arg Leu Ala Leu Glu Glu Ile Asp Asn Ala 
    50                  55                  60                  


Gly Phe Gly Trp Thr Gln Ala Lys Met Ile Met Ile Ala Gly Val Gly 
65                  70                  75                  80  


Phe Met Thr Asp Ser Tyr Asp Ile Phe Ala Ile Asn Leu Gly Thr Ser 
                85                  90                  95      


Met Leu Gly His Val Tyr Trp Gly Gly Thr Ile Pro Ser Ser Thr Gln 
            100                 105                 110         


Thr Leu Ile Lys Val Ser Thr Ser Val Gly Thr Val Ile Gly Gln Val 
        115                 120                 125             


Ser Phe Gly Met Phe Ala Asp Ile Val Gly Arg Lys Lys Ile Tyr Gly 
    130                 135                 140                 


Leu Glu Leu Ile Val Met Ile Phe Ala Thr Val Ile Gln Cys Thr Leu 
145                 150                 155                 160 


Gly Glu Ser Ala Ala Ile Ser Phe Pro Ala Ile Phe Ser Thr Met Arg 
                165                 170                 175     


Ile Leu Met Gly Ile Gly Ile Gly Gly Asp Tyr Pro Leu Ser Ser Ile 
            180                 185                 190         


Ile Ser Ser Glu Phe Ser Thr Thr Lys Trp Arg Gly Ala Ile Met Ala 
        195                 200                 205             


Ala Val Phe Ser Asn Gln Gly Leu Gly Gln Leu Leu Ala Gly Ile Val 
    210                 215                 220                 


Ala Leu Ile Ala Val Ser Gly Tyr Lys Asp Asp Leu Lys Tyr Ala Asn 
225                 230                 235                 240 


Thr Ala Lys Glu Cys Ile Gly Ser Cys Ile Lys Ala Asn Asp Gln Met 
                245                 250                 255     


Trp Arg Ile Leu Ile Gly Phe Gly Cys Val Pro Gly Cys Ile Ala Leu 
            260                 265                 270         


Tyr Tyr Arg Leu Thr Ile Ala Glu Ser Pro Arg Tyr Glu Leu Asp Val 
        275                 280                 285             


Gln Glu 
    290 


<210> 9
<211> 285
<212> PRT
<213> Saccharomyces cerevisiae

<400> 9
Met Ser Ser Val Asn Lys Asp Thr Ile His Val Ala Glu Arg Ser Leu 
1               5                   10                  15      


His Lys Glu His Leu Thr Glu Gly Gly Asn Met Ala Phe His Asn His 
            20                  25                  30          


Leu Asn Asp Phe Ala His Ile Glu Asp Pro Leu Glu Arg Arg Arg Leu 
        35                  40                  45              


Ala Leu Glu Ser Ile Asp Asp Glu Gly Phe Gly Trp Gln Gln Val Lys 
    50                  55                  60                  


Thr Ile Ser Ile Ala Gly Val Gly Phe Leu Thr Asp Ser Tyr Asp Ile 
65                  70                  75                  80  


Phe Ala Ile Asn Leu Gly Ile Thr Met Met Ser Tyr Val Tyr Trp His 
                85                  90                  95      


Gly Ser Met Pro Gly Pro Ser Gln Thr Leu Leu Lys Val Ser Thr Ser 
            100                 105                 110         


Val Gly Thr Val Ile Gly Gln Phe Gly Phe Gly Thr Leu Ala Asp Ile 
        115                 120                 125             


Val Gly Arg Lys Arg Ile Tyr Gly Met Glu Leu Ile Ile Met Ile Val 
    130                 135                 140                 


Cys Thr Ile Leu Gln Thr Thr Val Ala His Ser Pro Ala Ile Asn Phe 
145                 150                 155                 160 


Val Ala Val Leu Thr Phe Tyr Arg Ile Val Met Gly Ile Gly Ile Gly 
                165                 170                 175     


Gly Asp Tyr Pro Leu Ser Ser Ile Ile Thr Ser Glu Phe Ala Thr Thr 
            180                 185                 190         


Lys Trp Arg Gly Ala Ile Met Gly Ala Val Phe Ala Asn Gln Ala Trp 
        195                 200                 205             


Gly Gln Ile Ser Gly Gly Ile Ile Ala Leu Ile Leu Val Ala Ala Tyr 
    210                 215                 220                 


Lys Gly Glu Leu Glu Tyr Ala Asn Ser Gly Ala Glu Cys Asp Ala Arg 
225                 230                 235                 240 


Cys Gln Lys Ala Cys Asp Gln Met Trp Arg Ile Leu Ile Gly Leu Gly 
                245                 250                 255     


Thr Val Leu Gly Leu Ala Cys Leu Tyr Phe Arg Leu Thr Ile Pro Glu 
            260                 265                 270         


Ser Pro Arg Tyr Gln Leu Asp Val Asn Ala Lys Leu Glu 
        275                 280                 285 


<210> 10
<211> 286
<212> PRT
<213> Candida glabrata

<400> 10
Met Ser Arg Asn Glu Lys Asp Glu Ile Glu Val Asp Thr Arg Glu Lys 
1               5                   10                  15      


Lys Val Pro Val His Ile Thr Glu Gly Gly Asn Met Ala Phe His Asn 
            20                  25                  30          


Tyr Leu Asn Asp Phe Ala His Ile Glu Asp Pro Leu Glu Arg Arg Arg 
        35                  40                  45              


Leu Ala Leu Gln Lys Ile Asp Glu Arg Pro Phe Gly Trp Asp Gln Val 
    50                  55                  60                  


Arg Thr Ile Leu Ile Ala Gly Val Gly Phe Leu Thr Asp Ser Tyr Asp 
65                  70                  75                  80  


Ile Phe Ala Ile Asn Leu Ser Ile Ser Met Met Ser Tyr Val Phe Trp 
                85                  90                  95      


Gln Gly Asn Met Pro Asn Ser Thr Gln Thr Leu Leu Lys Val Ser Thr 
            100                 105                 110         


Ser Val Gly Thr Val Ile Gly Gln Leu Gly Phe Gly Thr Met Ala Asp 
        115                 120                 125             


Ile Val Gly Arg Lys Lys Ile Tyr Gly Leu Glu Leu Ile Val Met Ile 
    130                 135                 140                 


Ala Thr Thr Ile Leu Gln Thr Thr Ile Gly Arg Ser Pro Gly Ile Asn 
145                 150                 155                 160 


Phe Pro Ala Val Leu Thr Phe Tyr Arg Ile Val Met Gly Ile Gly Ile 
                165                 170                 175     


Gly Gly Asp Tyr Pro Leu Ser Ser Ile Ile Thr Ser Glu Phe Ala Thr 
            180                 185                 190         


Thr Lys Trp Arg Gly Ala Ile Met Gly Ala Val Phe Ala Asn Gln Ala 
        195                 200                 205             


Trp Gly Gln Ile Ala Gly Gly Leu Val Ala Leu Ile Val Ile Arg Ala 
    210                 215                 220                 


Tyr Lys Gly Asp Leu Ile Tyr Ala Asn Ser Gly Ala Glu Cys Asp Tyr 
225                 230                 235                 240 


Ala Cys Gln Lys Ala Cys Asp Gln Met Trp Arg Ile Leu Ile Gly Phe 
                245                 250                 255     


Gly Ala Val Pro Gly Ile Ile Gly Leu Tyr Phe Arg Leu Thr Ile Pro 
            260                 265                 270         


Glu Ser Pro Arg Tyr Ala Leu Asp Val Lys Glu Glu Val Asp 
        275                 280                 285     


<210> 11
<211> 274
<212> PRT
<213> Coccidioides immitis

<400> 11
Met Ala Thr Leu Thr Ala Gly Gly Asn Ser Ala Phe Lys Asn Phe His 
1               5                   10                  15      


Asn Gln Phe Ala His Ile Gln Asp Pro Asn Glu Arg Arg Arg Leu Ala 
            20                  25                  30          


Leu Ala Glu Ile Asp Lys Ala Pro Phe Gly Trp Tyr His Ile Arg Ala 
        35                  40                  45              


Ile Val Val Ala Gly Ile Gly Phe Phe Thr Asp Ala Tyr Asp Ile Phe 
    50                  55                  60                  


Ala Ile Asn Leu Ala Ser Ala Met Leu Gly Val Val Phe Trp Leu Asp 
65                  70                  75                  80  


Ala Lys Asp Lys Pro Gly Lys Ile Pro Ser Ser Ala Asp Thr Ala Ile 
                85                  90                  95      


Lys Val Ala Thr Ser Gly Gly Thr Val Ile Gly Gln Val Gly Phe Gly 
            100                 105                 110         


Trp Leu Ala Asp Val Val Gly Arg Lys Lys Met Tyr Gly Leu Glu Leu 
        115                 120                 125             


Met Val Ile Ile Phe Ala Thr Leu Ala Gln Ala Leu Ser Ser Asp Ser 
    130                 135                 140                 


Pro Gly Val Ser Ile Val Gly Leu Leu Ile Phe Trp Arg Val Ile Met 
145                 150                 155                 160 


Gly Ile Gly Ile Gly Gly Asp Tyr Pro Leu Ser Ser Ile Ile Thr Ser 
                165                 170                 175     


Glu Phe Ala Thr Thr Lys Trp Arg Gly Ala Met Met Gly Ala Val Phe 
            180                 185                 190         


Ala Met Gln Gly Ile Gly Gln Phe Ala Ala Ala Leu Val Ala Leu Ile 
        195                 200                 205             


Val Ala Ala Gly Phe Lys Glu Ser Leu Lys Thr Ala Glu Ser Glu Ser 
    210                 215                 220                 


Gln Cys Ser Gly Val Cys Gln Val Ala Val Asp Lys Met Trp Arg Val 
225                 230                 235                 240 


Val Ile Gly Phe Gly Ala Val Pro Gly Cys Ile Ala Leu Tyr Tyr Arg 
                245                 250                 255     


Leu Thr Ile Pro Glu Thr Pro Arg Tyr Thr Phe Asp Val Gln Arg Asp 
            260                 265                 270         


Val Val 
        


<210> 12
<211> 273
<212> PRT
<213> Aspergillus fumigatus

<400> 12
Met Ala Ser Thr Gly Gly Gly Asn Ser Ala Phe Arg Asn Tyr Asn Asn 
1               5                   10                  15      


Glu Leu Ala His Val Glu Asp Ala Arg Glu Arg Arg Arg Gln Ala Leu 
            20                  25                  30          


Ala Glu Ile Asp Asn Ala Lys Phe Ser Trp Tyr His Val Arg Ala Val 
        35                  40                  45              


Val Val Ala Gly Val Gly Phe Phe Thr Asp Ser Tyr Asp Ile Phe Ala 
    50                  55                  60                  


Ile Asn Leu Ala Ser Ser Met Leu Gly Val Val Phe Trp Gln Asp Ala 
65                  70                  75                  80  


Lys Ser Ser Pro Gly Lys Ile Pro Ser Ser Ala Asp Thr Ala Ile Lys 
                85                  90                  95      


Val Ser Thr Ser Gly Gly Thr Val Ile Gly Gln Leu Phe Phe Gly Trp 
            100                 105                 110         


Leu Ala Asp Arg Ile Arg Met Tyr Gly Ile Glu Leu Met Val Ile Ile 
        115                 120                 125             


Met Ala Thr Leu Ala Gln Ala Leu Ser Ser Asp Ser Arg Ala Gly Arg 
    130                 135                 140                 


Lys Ile Ser Ile Val Gly Ile Leu Ile Phe Trp Arg Val Ile Met Gly 
145                 150                 155                 160 


Ile Gly Ile Gly Gly Asp Tyr Pro Leu Ser Ser Ile Ile Thr Ser Glu 
                165                 170                 175     


Phe Ala Thr Thr Lys Trp Arg Gly Ala Met Met Gly Ser Val Phe Ala 
            180                 185                 190         


Met Gln Gly Phe Gly Gln Phe Ala Ala Ala Ile Val Ala Leu Ile Val 
        195                 200                 205             


Thr Ala Gly Phe Lys Glu Ser Leu Glu Thr Ala Ser Ser Val Gly Lys 
    210                 215                 220                 


Cys Ser Gly Val Cys Gln Leu Ala Val Asp Lys Met Trp Arg Val Val 
225                 230                 235                 240 


Ile Gly Phe Gly Ala Val Pro Ala Cys Ile Ala Leu Tyr Tyr Arg Leu 
                245                 250                 255     


Thr Ile Pro Glu Thr Pro Arg Tyr Thr Phe Asp Val Ala His Asp Ile 
            260                 265                 270         


Val 
    


<210> 13
<211> 256
<212> PRT
<213> Cryptococcus neoformans

<400> 13
Met Ser Ser Gln Phe Glu Val Glu Lys Ala His Ala Asn Val Pro Met 
1               5                   10                  15      


Ser Ala Gly Glu Arg Arg Arg Ala Ala Leu Ala Glu Ile Asp Glu Ala 
            20                  25                  30          


Ser Phe Ser Trp Phe His Ala Lys Ala Cys Ile Val Ala Gly Val Gly 
        35                  40                  45              


Phe Phe Thr Asp Ala Tyr Asp Ile Phe Ser Ile Ser Ile Ala Ala Thr 
    50                  55                  60                  


Met Ile Gly Tyr Val Tyr His Asn Gly Gly Ser Asn Thr Ser Asn Gln 
65                  70                  75                  80  


Asp Leu Gly Ile Lys Val Ala His Ser Ile Gly Thr Phe Phe Gly Gln 
                85                  90                  95      


Leu Leu Phe Gly Tyr Leu Ala Asp His Ile Gly Arg Lys Arg Met Tyr 
            100                 105                 110         


Gly Val Glu Leu Ile Ile Ile Ile Ile Gly Thr Leu Gly Gln Ala Val 
        115                 120                 125             


Ala Gly His Ala Pro Gly Val Asn Ile Tyr Gly Val Leu Ile Met Trp 
    130                 135                 140                 


Arg Phe Ile Met Gly Ile Gly Ile Gly Gly Asp Tyr Pro Val Ser Ser 
145                 150                 155                 160 


Val Ile Thr Ser Glu Phe Ala Ala Arg Lys Ile Arg Gly Arg Met Met 
                165                 170                 175     


Ala Ala Val Phe Ser Ala Gln Gly Trp Gly Asn Phe Thr Cys Ala Ile 
            180                 185                 190         


Val Ala Val Ile Val Val Ala Ala Tyr Lys Asp Ser Ile His Ser Gln 
        195                 200                 205             


Pro Leu Asp Asp Leu Lys Ser Val Asp Gln Ala Trp Arg Leu Ile Ile 
    210                 215                 220                 


Gly Ile Gly Cys Val Pro Ala Val Ile Ala Leu Tyr Phe Arg Leu Thr 
225                 230                 235                 240 


Ile Pro Glu Thr Pro Arg Tyr Thr Met Asp Val Glu Arg Asn Ile Lys 
                245                 250                 255     


<210> 14
<211> 256
<212> PRT
<213> Cryptococcus gattii

<400> 14
Met Ser Ser Gln Phe Glu Val Glu Lys Thr Gln Ala Asn Val Ser Met 
1               5                   10                  15      


Ser Ala Gly Glu Arg Arg Arg Ala Ala Leu Ala Glu Ile Asp Glu Ala 
            20                  25                  30          


Arg Phe Ser Trp Phe His Ala Lys Ala Cys Val Val Ala Gly Val Gly 
        35                  40                  45              


Phe Phe Thr Asp Ala Tyr Asp Ile Phe Ser Ile Ser Ile Ala Ala Thr 
    50                  55                  60                  


Met Ile Gly Tyr Val Tyr His Asn Gly Gly Ser Asn Thr Ser Asn Gln 
65                  70                  75                  80  


Asp Leu Gly Ile Lys Val Ala His Ser Ile Gly Thr Phe Phe Gly Gln 
                85                  90                  95      


Leu Ser Phe Gly Tyr Leu Ala Asp His Ile Gly Arg Lys Arg Met Tyr 
            100                 105                 110         


Gly Val Glu Leu Met Ile Ile Ile Val Gly Thr Leu Gly Gln Ala Val 
        115                 120                 125             


Ala Gly His Ala Pro Gly Val Asn Ile Tyr Gly Val Leu Ile Met Trp 
    130                 135                 140                 


Arg Phe Ile Met Gly Ile Gly Ile Gly Gly Asp Tyr Pro Val Ser Ser 
145                 150                 155                 160 


Val Ile Thr Ser Glu Phe Ala Ala Arg Lys Ile Arg Gly Arg Met Met 
                165                 170                 175     


Ala Ala Val Phe Ser Ala Gln Gly Trp Gly Asn Phe Ala Cys Ala Ile 
            180                 185                 190         


Val Ala Val Ile Val Val Ala Ala Tyr Lys Ser Ser Ile Lys Ser Gln 
        195                 200                 205             


Pro Leu Asp Asp Leu Lys Ala Val Asp Gln Ala Trp Arg Leu Ile Ile 
    210                 215                 220                 


Gly Ile Gly Cys Val Pro Ala Val Ile Ala Leu Tyr Phe Arg Leu Thr 
225                 230                 235                 240 


Ile Pro Glu Thr Pro Arg Tyr Thr Met Asp Val Glu Arg Asn Ile Lys 
                245                 250                 255     


<210> 15
<211> 276
<212> PRT
<213> Lichtheimia ramosa

<400> 15
Met Ser Lys Pro Asn Leu Pro Glu Gly Ala Thr Pro Val Val Ala Thr 
1               5                   10                  15      


Thr Thr Thr Thr Thr Thr Val Val Thr Asp Ser Gln Ser Ser His Glu 
            20                  25                  30          


Ala Gln Ser Tyr Gly Leu Asp Ala Ile Glu Arg Arg Arg Ile Ala Leu 
        35                  40                  45              


Gln Glu Phe Asp Asp Ala Lys Phe Gly Trp Phe His Ile Arg Ala Cys 
    50                  55                  60                  


Ile Val Ser Gly Val Gly Phe Phe Thr Asp Ala Tyr Asp Ile Phe Ala 
65                  70                  75                  80  


Ile Asn Leu Val Ser Thr Met Ile Gly Tyr Val Tyr Trp Gly Ala Glu 
                85                  90                  95      


Gly Asn Thr Thr Pro His Asn Val Asp Thr Ala Ile Lys Val Ser Met 
            100                 105                 110         


Ser Cys Gly Thr Val Val Gly Gln Leu Leu Phe Gly Tyr Leu Ala Asp 
        115                 120                 125             


His Val Gly Arg Lys Arg Met Tyr Gly Val Glu Leu Ile Ile Met Ile 
    130                 135                 140                 


Val Gly Thr Ile Gly Gln Thr Leu Ala Gly Asn Gly Pro Ala Ala Ser 
145                 150                 155                 160 


Phe Trp Ala Val Ile Thr Phe Trp Arg Val Ile Val Gly Ile Gly Ile 
                165                 170                 175     


Gly Gly Asp Tyr Pro Leu Ser Ser Val Ile Thr Ser Glu Phe Ala Thr 
            180                 185                 190         


Thr Lys Arg Arg Gly Ala Met Met Ala Ala Val Phe Ala Met Gln Gly 
        195                 200                 205             


Ile Gly Gln Val Thr Ala Gly Ile Val Gly Leu Ile Ala Thr Ala Ala 
    210                 215                 220                 


Tyr Gln Asn Ala Ile Arg Ala Asp Pro Thr Gln Leu Asp Tyr Val Trp 
225                 230                 235                 240 


Arg Ile Val Ile Gly Leu Gly Ala Val Pro Gly Val Val Ala Leu Tyr 
                245                 250                 255     


Tyr Arg Leu Thr Ile Pro Glu Thr Pro Arg Tyr Thr Met Asp Val Glu 
            260                 265                 270         


Gln Lys Ile Glu 
        275     


<210> 16
<211> 202
<212> PRT
<213> Entamoeba histolytica

<400> 16
Met His Pro Leu Val Lys Thr Phe Val Val Ser Ile Gly Met Met Thr 
1               5                   10                  15      


Asp Ala Tyr Glu Ile Phe Leu Met Asn Ile Cys Tyr Val Ile Ile Lys 
            20                  25                  30          


Glu Ile Tyr Gly Glu Thr Ser Tyr Ser Ser Thr Leu Ser Ser Ala Val 
        35                  40                  45              


Leu Val Gly Met Ala Ile Gly Gln Leu Leu Phe Gly Val Leu Ala Asp 
    50                  55                  60                  


Thr Ile Gly Lys Lys Leu Met Phe Ile Thr Thr Leu Thr Ile Leu Ile 
65                  70                  75                  80  


Ile Phe Ser Ile Leu Gln Ala Phe Ser Phe Glu Val Ile Ser Gly Ala 
                85                  90                  95      


Gly Pro Tyr Ile Ile Leu Ala Val Ile Arg Phe Ile Leu Gly Leu Gly 
            100                 105                 110         


Ile Gly Gly Glu Tyr Pro Leu Ser Ser Ser Ile Ala Ser Glu Asp Ala 
        115                 120                 125             


Lys Pro His Asn Arg Gly Arg Lys Leu Val Phe Ile Phe Ser Met Gln 
    130                 135                 140                 


Gly Ile Gly Asn Ile Leu Ala Pro Leu Val Val Leu Ile Leu Leu Tyr 
145                 150                 155                 160 


Thr Pro Leu Lys Leu Asp Tyr Val Trp Arg Thr Ala Leu Ala Leu Gly 
                165                 170                 175     


Ala Val Pro Cys Ile Leu Thr Leu Tyr His Arg Val Ile Met Asp Met 
            180                 185                 190         


Pro Lys Lys Lys Lys Asp His Val Thr Ser 
        195                 200         


