                         SEQUENCE LISTING

<110>  Doudna, Jennifer A
       Harrington, Lucas B
       Kyrpides, Nikos
       Paez-Espino, David
 
<120>  THERMOSTABLE RNA-GUIDED ENDONUCLEASES AND METHODS OF USE THEREOF

<130>  BERK-357WO

<150>  US 62/507,123
<151>  2017-05-16

<160>  140   

<170>  PatentIn version 3.5

<210>  1
<211>  1087
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  1

Met Arg Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Met Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Gln Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Val Ile Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asp Lys Leu Phe Glu Glu Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Ser Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Arg Ala Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Pro Lys Phe Ala Leu His Lys Arg Asn 
                165                 170                 175     


Lys Gly Glu Asn Tyr Thr Asn Thr Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Arg Leu Ile Phe Ser Lys Gln Arg Glu Phe Gly Asn Met Ser 
        195                 200                 205             


Cys Thr Glu Glu Phe Glu Asn Glu Tyr Ile Thr Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Val Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Ala Trp Glu His Ile Asn Lys Leu Arg Leu Ile Ser 
            260                 265                 270         


Pro Ser Gly Ala Arg Gly Leu Thr Asp Glu Glu Arg Arg Leu Leu Tyr 
        275                 280                 285             


Glu Gln Ala Phe Gln Lys Asn Lys Ile Thr Tyr His Asp Ile Arg Thr 
    290                 295                 300                 


Leu Leu His Leu Pro Asp Asp Thr Tyr Phe Lys Gly Ile Val Tyr Asp 
305                 310                 315                 320 


Arg Gly Glu Ser Arg Lys Gln Asn Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ala Tyr His Gln Ile Arg Lys Ala Val Asp Lys Val Tyr Gly Lys 
            340                 345                 350         


Gly Lys Ser Ser Ser Phe Leu Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Leu Phe Lys Asp Asp Ala Asp Ile His Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Pro Asn Leu Ala Asn Lys 
385                 390                 395                 400 


Val Tyr Asp Asn Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Thr 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Ser Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Ser Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Met Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Asp Leu Ser Gln Thr Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Thr Lys Lys Glu Gln Asp Glu Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Met Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


His Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Arg Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Arg Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Ile Pro Ala Glu Tyr Leu Gly Val Gly Thr Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Thr 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Phe Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Glu Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Val Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Glu Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Val Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Lys Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ala 
            740                 745                 750         


Lys Lys Thr Glu Pro His Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Arg Ala Arg Leu Ser Lys His Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asp Gln Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Val Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu Asp Ala 
        835                 840                 845             


Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro Gly 
                885                 890                 895     


Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val Tyr 
    930                 935                 940                 


Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu Pro Arg 
            980                 985                 990         


Glu Lys Thr Val Lys Thr Ala Ala  Gly Glu Glu Ile Asn  Val Lys Asp 
        995                 1000                 1005             


Val Phe  Val Tyr Tyr Lys Thr  Ile Asp Ser Ala Asn  Gly Gly Leu 
    1010                 1015                 1020             


Glu Leu  Ile Ser His Asp His  Arg Phe Ser Leu Arg  Gly Val Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Leu Ala 
    1055                 1060                 1065             


Ser Ser  Ala His Ser Lys Pro  Gly Lys Thr Ile Arg  Pro Leu Gln 
    1070                 1075                 1080             


Ser Thr  Arg Asp 
    1085         


<210>  2
<211>  1087
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  2

Met Arg Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Met Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Gln Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Val Ile Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asp Lys Leu Phe Glu Glu Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Ser Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Arg Ala Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Pro Lys Phe Ala Leu His Lys Arg Asn 
                165                 170                 175     


Lys Gly Glu Asn Tyr Thr Asn Thr Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Arg Leu Ile Phe Ser Lys Gln Arg Glu Phe Gly Asn Met Ser 
        195                 200                 205             


Cys Thr Glu Glu Phe Glu Asn Glu Tyr Ile Thr Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Val Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Ala Trp Glu His Ile Asn Lys Leu Arg Leu Ile Ser 
            260                 265                 270         


Pro Ser Gly Ala Arg Gly Leu Thr Asp Glu Glu Arg Arg Leu Leu Tyr 
        275                 280                 285             


Glu Gln Ala Phe Gln Lys Asn Lys Ile Thr Tyr His Asp Ile Arg Thr 
    290                 295                 300                 


Leu Leu His Leu Pro Asp Asp Thr Tyr Phe Lys Gly Ile Val Tyr Asp 
305                 310                 315                 320 


Arg Gly Glu Ser Arg Lys Gln Asn Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ala Tyr His Gln Ile Arg Lys Ala Val Asp Lys Val Tyr Gly Lys 
            340                 345                 350         


Gly Lys Ser Ser Ser Phe Leu Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Leu Phe Lys Asp Asp Ala Asp Ile His Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Pro Asn Leu Ala Asn Lys 
385                 390                 395                 400 


Val Tyr Asp Asn Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Thr 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Ser Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Ser Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Met Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Asp Leu Ser Gln Thr Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Thr Lys Lys Glu Gln Asp Glu Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Met Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


His Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Arg Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Arg Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Ile Pro Ala Glu Tyr Leu Gly Val Gly Thr Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Thr 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Phe Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Glu Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Val Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Glu Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Val Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Lys Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ala 
            740                 745                 750         


Lys Lys Thr Glu Pro His Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Arg Ala Arg Leu Ser Lys His Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asp Gln Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Val Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu Asp Ala 
        835                 840                 845             


Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro Gly 
                885                 890                 895     


Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val Tyr 
    930                 935                 940                 


Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu Pro Arg 
            980                 985                 990         


Glu Lys Ile Ile Lys Thr Ala Gly  Gly Glu Glu Ile Lys  Ile Lys Asp 
        995                 1000                 1005             


Leu Phe  Ala Tyr Tyr Lys Thr  Ile His Ser Gly Thr  Ala Gly Leu 
    1010                 1015                 1020             


Glu Leu  Val Ser His Asp Cys  Ser Phe Ser Leu Ser  Gly Val Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Leu Ala 
    1055                 1060                 1065             


Ser Ser  Ala His Ser Lys Thr  Gly Glu Thr Ile Arg  Pro Leu Gln 
    1070                 1075                 1080             


Ser Thr  Arg Asp 
    1085         


<210>  3
<211>  1087
<212>  PRT
<213>  Geobacillus LC300

<400>  3

Met Arg Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Gln Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Ile Ile Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asp Lys Leu Phe Glu Glu Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Ser Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Arg Ala Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Pro Lys Phe Ala Leu His Lys Arg Asn 
                165                 170                 175     


Lys Gly Glu Asn Tyr Thr Asn Thr Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Arg Leu Ile Phe Ser Lys Gln Arg Glu Phe Gly Asn Met Ser 
        195                 200                 205             


Cys Thr Glu Glu Phe Glu Asn Glu Tyr Ile Ala Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Val Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Ala Trp Glu His Ile Asn Lys Leu Arg Leu Ile Ser 
            260                 265                 270         


Pro Ser Gly Thr Arg Gly Leu Thr Asp Glu Glu Arg Arg Leu Leu Tyr 
        275                 280                 285             


Glu Gln Ala Phe Gln Lys Asn Lys Ile Thr Tyr His Asp Ile Arg Thr 
    290                 295                 300                 


Leu Leu His Leu Pro Asp Asp Thr Tyr Phe Lys Gly Ile Val Tyr Asp 
305                 310                 315                 320 


Arg Gly Glu Ser Arg Lys Gln Asn Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ala Tyr His Gln Ile Arg Lys Ala Val Asp Lys Val Tyr Gly Lys 
            340                 345                 350         


Gly Lys Ser Ser Ser Phe Leu Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Leu Phe Lys Asp Asp Ala Asp Ile Arg Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Pro Asn Leu Ala Asn Lys 
385                 390                 395                 400 


Val Tyr Asp Asn Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Thr 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Ser Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Ser Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Met Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Asp Leu Ser Gln Thr Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Thr Lys Lys Glu Gln Asp Glu Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Met Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


His Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Arg Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Ile Pro Ala Glu Tyr Leu Gly Val Gly Thr Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Thr 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Phe Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Glu Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Val Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Glu Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Val Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Lys Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ala 
            740                 745                 750         


Lys Lys Thr Glu Pro His Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Arg Ala Arg Leu Ser Lys His Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asp Gln Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Val Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu Asp Ala 
        835                 840                 845             


Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro Gly 
                885                 890                 895     


Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val Tyr 
    930                 935                 940                 


Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu Pro Arg 
            980                 985                 990         


Glu Lys Ile Ile Lys Thr Ala Gly  Gly Glu Glu Ile Lys  Ile Lys Asp 
        995                 1000                 1005             


Leu Phe  Ala Tyr Tyr Lys Thr  Ile His Ser Gly Thr  Ala Gly Leu 
    1010                 1015                 1020             


Glu Leu  Val Ser His Asp Cys  Ser Phe Ser Leu Ser  Gly Val Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Leu Ala 
    1055                 1060                 1065             


Ser Ser  Ala His Ser Lys Thr  Gly Glu Thr Ile Arg  Pro Leu Gln 
    1070                 1075                 1080             


Ser Thr  Arg Asp 
    1085         


<210>  4
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  4

Ile Ile Lys Thr Ala Gly Gly Glu Glu Ile Lys Ile Lys Asp Leu Phe 
1               5                   10                  15      


Ala Tyr Tyr Lys Thr Ile His Ser Gly Thr Ala Gly Leu Glu Leu Val 
            20                  25                  30          


Ser His Asp Cys Ser Phe Ser Leu Ser Gly Val Gly Ser Arg Thr Leu 
        35                  40                  45              


Lys Arg Phe Glu Lys Tyr Gln Val Asp Val Leu Gly Asn Ile Tyr Lys 
    50                  55                  60                  


Val Arg Gly Glu Lys Arg Val Gly Leu Ala Ser Ser Ala His Ser Lys 
65                  70                  75                  80  


Thr Gly Glu Thr Ile Arg Pro Leu Gln Ser Thr Arg Asp 
                85                  90              


<210>  5
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  5

Thr Val Lys Thr Ala Ala Gly Glu Glu Ile Asn Val Lys Asp Val Phe 
1               5                   10                  15      


Val Tyr Tyr Lys Thr Ile Asp Ser Ala Asn Gly Gly Leu Glu Leu Ile 
            20                  25                  30          


Ser His Asp His Arg Phe Ser Leu Arg Gly Val Gly Ser Arg Thr Leu 
        35                  40                  45              


Lys Arg Phe Glu Lys Tyr Gln Val Asp Val Leu Gly Asn Ile Tyr Lys 
    50                  55                  60                  


Val Arg Gly Glu Lys Arg Val Gly Leu Ala Ser Ser Ala His Ser Lys 
65                  70                  75                  80  


Pro Gly Lys Thr Ile Arg Pro Leu Gln Ser Thr Arg Asp 
                85                  90              


<210>  6
<211>  98
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6
ucaggguuac uaugauaagg gcuuucugcc uaaggcagac ugacccgcgg cguuggggau       60

cgccugucgc ccgcuuuugg cgggcauucc ccauccuu                               98


<210>  7
<211>  138
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  7
nnnnnnnnnn nnnnnnnnnn gucauaguuc cccugagaaa ucaggguuac uaugauaagg       60

gcuuucugcc uaaggcagac ugacccgcgg cguuggggau cgccugucgc ccgcuuuugg      120

cgggcauucc ccauccuu                                                    138


<210>  8
<211>  84
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  9
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  10
<211>  85
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  11
<211>  76
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  12
<211>  76
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  13
<211>  72
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  14
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  15
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  16
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys 
    50                  55          


<210>  17
<211>  65
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17

Met Glu Ser Leu Ala Ala Thr Ser Val Phe Ala Pro Ser Arg Val Ala 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Leu Val Arg Ala Gly Thr Val Val Pro Thr 
            20                  25                  30          


Arg Arg Thr Ser Ser Thr Ser Gly Thr Ser Gly Val Lys Cys Ser Ala 
        35                  40                  45              


Ala Val Thr Pro Gln Ala Ser Pro Val Ile Ser Arg Ser Ala Ala Ala 
    50                  55                  60                  


Ala 
65  


<210>  18
<211>  72
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  19
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  24
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  25
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  26
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  27
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  30
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  31
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31

Asp Arg Leu Arg Arg 
1               5   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  37
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  38
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  38

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  39
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  39

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  40
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  40

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  41
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  41

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  42
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  42

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  43
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  43

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  44
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  44

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  45

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  46

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  47
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  47

Gly Ser Gly Gly Ser 
1               5   


<210>  48
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  48

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  49
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  49

Gly Gly Gly Ser 
1               


<210>  50
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  50

Gly Gly Ser Gly 
1               


<210>  51
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  51

Gly Gly Ser Gly Gly 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  52

Gly Ser Gly Ser Gly 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  53

Gly Ser Gly Gly Gly 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  54

Gly Gly Gly Ser Gly 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  55

Gly Ser Ser Ser Gly 
1               5   


<210>  56
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  56
ggctgtaagc ggatgccata tggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt                                                  140


<210>  57
<211>  155
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  57
ggctgtaagc ggatgccata tggtcatagt tcccctgaga ttatcgcgaa aatgatctca       60

gggttactat gataagggct ttctgcctaa ggcagactga cccgcggcgt tggggatcgc      120

ctgtcgcccg cttttggcgg gcattcccca tcctt                                 155


<210>  58
<211>  177
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  58
ggctgtaagc ggatgccata tggtcatagt tcccctgaga ttatcgctgt ggtataatga       60

aaataccaca gcaatgatct cagggttact atgataaggg ctttctgcct aaggcagact      120

gacccgcggc gttggggatc gcctgtcgcc cgcttttggc gggcattccc catcctt         177


<210>  59
<211>  105
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  59
ggctgtaagc ggatgccata tggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgc                      105


<210>  60
<211>  133
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  60
ggctgtaagc ggatgccata tggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccc                                                         133


<210>  61
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  61
ggctgtaagc ggatgccata tggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt                                                  140


<210>  62
<211>  182
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  62
ggctgtaagc ggatgccata tggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt gcgcaaactc agaccttggc ggaaaacgct aaggtctttt      180

tt                                                                     182


<210>  63
<211>  139
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  63
ggtgtaagcg gatgccatat ggtcatagtt cccctgagaa atcagggtta ctatgataag       60

ggctttctgc ctaaggcaga ctgacccgcg gcgttgggga tcgcctgtcg cccgcttttg      120

gcgggcattc cccatcctt                                                   139


<210>  64
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  64
ggctgtaagc ggatgccata tggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt                                                  140


<210>  65
<211>  141
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  65
ggtctgtaag cggatgccat atggtcatag ttcccctgag aaatcagggt tactatgata       60

agggctttct gcctaaggca gactgacccg cggcgttggg gatcgcctgt cgcccgcttt      120

tggcgggcat tccccatcct t                                                141


<210>  66
<211>  142
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  66
gggtctgtaa gcggatgcca tatggtcata gttcccctga gaaatcaggg ttactatgat       60

aagggctttc tgcctaaggc agactgaccc gcggcgttgg ggatcgcctg tcgcccgctt      120

ttggcgggca ttccccatcc tt                                               142


<210>  67
<211>  141
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  67
ggtctgtaag cggatgccat atggtcatag ttcccctgag aaatcagggt tactatgata       60

agggctttct gcctaaggca gactgacccg cggcgttggg gatcgcctgt cgcccgcttt      120

tggcgggcat tccccatcct t                                                141


<210>  68
<211>  139
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  68
ggagctggac ggcgacgtaa agtcatagtt cccctgagaa atcagggtta ctatgataag       60

ggctttctgc ctaaggcaga ctgacccgcg gcgttgggga tcgcctgtcg cccgcttttg      120

gcgggcattc cccatcctt                                                   139


<210>  69
<211>  138
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  69
ggagcgcacc atcttcttca gtcatagttc ccctgagaaa tcagggttac tatgataagg       60

gctttctgcc taaggcagac tgacccgcgg cgttggggat cgcctgtcgc ccgcttttgg      120

cgggcattcc ccatcctt                                                    138


<210>  70
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  70
ggcctgagca cccagtccgc ccgtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt                                                  140


<210>  71
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  71
ggtgcggttc accagggtgt cggtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt                                                  140


<210>  72
<211>  139
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  72
caaatgaaag gagtgagagg tgtcatagtt cccctgagaa atcagggtta ctatgataag       60

ggctttctgc ctaaggcaga ctgacccgcg gcgttgggga tcgcctgtcg cccgcttttg      120

gcgggcattc cccatcctt                                                   139


<210>  73
<211>  140
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  73
ccaaatgaaa ggagtgagag gtgtcatagt tcccctgaga aatcagggtt actatgataa       60

gggctttctg cctaaggcag actgacccgc ggcgttgggg atcgcctgtc gcccgctttt      120

ggcgggcatt ccccatcctt                                                  140


<210>  74
<211>  103
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  74
gtggctaaag ccagggagac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttt                        103


<210>  75
<211>  139
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  75
gactccaatg cggaagagag tgtcatagtt cccctgagaa atcagggtta ctatgataag       60

ggctttctgc ctaaggcaga ctgacccgcg gcgttgggga tcgcctgtcg cccgcttttg      120

gcgggcattc cccatcctt                                                   139


<210>  76
<211>  141
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  76
gcgactccaa tgcggaagag agtgtcatag ttcccctgag aaatcagggt tactatgata       60

agggctttct gcctaaggca gactgacccg cggcgttggg gatcgcctgt cgcccgcttt      120

tggcgggcat tccccatcct t                                                141


<210>  77
<211>  104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  77
gactccaatg cggaagagag tgttttagag ctagaaatag caagttaaaa taaggctagt       60

ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt tttt                       104


<210>  78
<211>  141
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  78
ggcagctgag gcaggtgcct gctgtcatag ttcccctgag aaatcagggt tactatgata       60

agggctttct gcctaaggca gactgacccg cggcgttggg gatcgcctgt cgcccgcttt      120

tggcgggcat tccccatcct t                                                141


<210>  79
<211>  105
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  79
ggctgtaagc ggatgccata tggttttaga gctagaaata gcaagttaaa ataaggctag       60

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttt                      105


<210>  80
<211>  104
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  80
gagtacgtta atgtttcctg agttttagag ctagaaatag caagttaaaa taaggctagt       60

ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt tttt                       104


<210>  81
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  81
gggtggaggg gacagataaa agtac                                             25


<210>  82
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  82
acgtgatgtc ctctgagcgg atc                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  83
tccaccaacg ccgacggtat cag                                               23


<210>  84
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  84
gcagaagcca gtagagctca aagtggtc                                          28


<210>  85
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  85
cctcacacaa cagcttcatg tcagc                                             25


<210>  86
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  86
gccaaagccc gagagagtgc c                                                 21


<210>  87
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  87
tcacggtcac agctgatggt gtaagcggat gccatatgtg ggcaaactgc ccgctt           56


<210>  88
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  88
aagcgggcag tttgcccaca tatggcatcc gcttacacca tcagctgtga ccgtga           56


<210>  89
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  89
tcacggtcac agctgatggt gtaagcggat gccatatgtg gggaaactgc ccgctt           56


<210>  90
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  90
aagcgggcag tttccccaca tatggcatcc gcttacacca tcagctgtga ccgtga           56


<210>  91
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  91
tcacggtcac agctgatggt gtaagcggat gccatatgtg ggcgaactgc ccgctt           56


<210>  92
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  92
aagcgggcag ttcgcccaca tatggcatcc gcttacacca tcagctgtga ccgtga           56


<210>  93
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  93
tcacggtcac agctgatggt gtaagcggat gccatatgtg gggcaactgc ccgctt           56


<210>  94
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  94
aagcgggcag ttgccccaca tatggcatcc gcttacacca tcagctgtga ccgtga           56


<210>  95
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  95
tcacggtcac agctgatggt gtaagcggat gccatatgtg ggctaactgc ccgctt           56


<210>  96
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  96
aagcgggcag ttagcccaca tatggcatcc gcttacacca tcagctgtga ccgtga           56


<210>  97
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  97
tcacggtcac agctgatggt gtaagcggat gccatatgtg gggaagctgc ccgctt           56


<210>  98
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  98
aagcgggcag cttccccaca tatggcatcc gcttacacca tcagctgtga ccgtga           56


<210>  99
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  99
tcacggtcac agctggtctg taagcggatg ccatatgtgg gcaaactgcc cgctt            55


<210>  100
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  100
aagcgggcag tttgcccaca tatggcatcc gcttacagac cagctgtgac cgtga            55


<210>  101
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  101
cctcactcgc aacagtttcc accatgtcc                                         29


<210>  102
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  102
aaggcttatg attacttagt tgatttatgg                                        30


<210>  103
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  103
cgcagtatgc atttacacga aaaccagaag                                        30


<210>  104
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  104
atcgataatc gccaataacg caaatcccta                                        30


<210>  105
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  105
cagcgataaa gctataattc atcagttagt                                        30


<210>  106
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  106
cgttggtgag ggacataacc gaagcgctg                                         29


<210>  107
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  107
caaagacatg agaatgctgg cgcaggtgat                                        30


<210>  108
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  108
acaaatgata gacggggact acagacataa                                        30


<210>  109
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  109
aacaatgatt ttccctacgc cggtggtaa                                         29


<210>  110
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  110
aaatatgaaa ctctgacatc ttcaaatcag                                        30


<210>  111
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  111
tgcccatgcg acggcatgct ccttcatttc                                        30


<210>  112
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  112
gcttttttat ccaccttggc cggctgtggg                                        30


<210>  113
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  113
atttccagca gtcttttgac gacaaactg                                         29


<210>  114
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  114
agtttttagg ccgtagcggc tcgaatacgg                                        30


<210>  115
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  115
atgtctttag tctcattggt gccgtatggt                                        30


<210>  116
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  116
tgttcttgac ttctacagtc aacaaataaa                                        30


<210>  117
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  117
actgttcccc ttgaactgag tgacgcctt                                         29


<210>  118
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  118
ggtcggccag ccgatcagca cgcacacgga                                        30


<210>  119
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  119
gttgagcaag tagaaaggcg atggaggtt                                         29


<210>  120
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  120
tcacacccct tttttgtctg tcgccgctca                                        30


<210>  121
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  121
catgaatcga aaggccgttt ttatacataa                                        30


<210>  122
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  122
ttccctcgct gatttctccg cgtgcgaatt g                                      31


<210>  123
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  123
taaatacgtc aacatctacg tggatatgga a                                      31


<210>  124
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  124
ccggggcctt tttgttatgg ccgatggtat                                        30


<210>  125
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  125
tcagtctcga cccagagggg acagtcaagg a                                      31


<210>  126
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  126
cggactgata cccaacacaa caaaggaggc                                        30


<210>  127
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  127
tcggagtgac gttgttcggc ctgcgacgag                                        30


<210>  128
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  128
tccgcctgaa gctccgtatg tagcggatag                                        30


<210>  129
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  129
ttgaacaggc atagggaggg gactaaatga                                        30


<210>  130
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  130
aagtgacgta agataaagac cgaaatcag                                         29


<210>  131
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  131
cgcatccagg gctcgcccta tatcccaagg                                        30


<210>  132
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  132
ttgctccgac tatccgaaat caagcgatac                                        30


<210>  133
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  133

Met Arg Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Met Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Gln Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


<210>  134
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  134

Lys His Arg Leu Glu Arg Ile Arg Arg Leu Val Ile Arg Glu Gly Ile 
1               5                   10                  15      


Leu Thr Lys Glu Glu Leu Asp Lys Leu Phe Glu Glu Lys His Glu Ile 
            20                  25                  30          


Asp Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn 
        35                  40                  45              


Asp Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe 
    50                  55                  60                  


Lys Ser Asn Arg Lys Ser Glu Arg Ser Asn Lys Glu Asn Ser Thr Met 
65                  70                  75                  80  


Leu Lys His Ile Glu Glu Asn Arg Ala Ile Leu Ser Ser Tyr Arg Thr 
                85                  90                  95      


Val Gly Glu Met Ile Val Lys Asp Pro Lys Phe Ala Leu His Lys Arg 
            100                 105                 110         


Asn Lys Gly Glu Asn Tyr Thr Asn Thr Ile Ala Arg Asp Asp Leu Glu 
        115                 120                 125             


Arg Glu Ile Arg Leu Ile Phe Ser Lys Gln Arg Glu Phe Gly Asn Met 
    130                 135                 140                 


Ser Cys Thr Glu Glu Phe Glu Asn Glu Tyr Ile Thr Ile Trp Ala Ser 
145                 150                 155                 160 


Gln Arg Pro Val Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe 
                165                 170                 175     


Cys Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr 
            180                 185                 190         


Phe Gln Ser Phe Ile Ala Trp Glu His Ile Asn Lys Leu Arg Leu Ile 
        195                 200                 205             


Ser Pro Ser Gly Ala Arg Gly Leu Thr Asp Glu Glu Arg Arg Leu Leu 
    210                 215                 220                 


Tyr Glu Gln Ala Phe Gln Lys Asn Lys Ile Thr Tyr His Asp Ile Arg 
225                 230                 235                 240 


Thr Leu Leu His Leu Pro Asp Asp Thr Tyr Phe Lys Gly Ile Val Tyr 
                245                 250                 255     


Asp Arg Gly Glu Ser Arg Lys Gln Asn Glu Asn Ile Arg Phe Leu Glu 
            260                 265                 270         


Leu Asp Ala Tyr His Gln Ile Arg Lys Ala Val Asp Lys Val Tyr Gly 
        275                 280                 285             


Lys Gly Lys Ser Ser Ser Phe Leu Pro Ile Asp Phe Asp Thr Phe Gly 
    290                 295                 300                 


Tyr Ala Leu Thr Leu Phe Lys Asp Asp Ala Asp Ile His Ser Tyr Leu 
305                 310                 315                 320 


Arg Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Pro Asn Leu Ala Asn 
                325                 330                 335     


Lys Val Tyr Asp Asn Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe 
            340                 345                 350         


Thr Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Ser Ile Leu Pro 
        355                 360                 365             


Tyr Met Glu Gln Gly Glu Val Tyr Ser Ser Ala Cys Glu Arg Ala Gly 
    370                 375                 380                 


Tyr Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr 
385                 390                 395     


<210>  135
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  135

Met Leu Leu Pro Asn Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg 
1               5                   10                  15      


Ala Leu Thr Gln Ala Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr 
            20                  25                  30          


Gly Ser Pro Val Ser Ile His Ile Glu Leu Ala Arg Asp Leu Ser Gln 
        35                  40                  45              


Thr Phe Asp Glu 
    50          


<210>  136
<211>  151
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  136

Arg Arg Lys Thr Lys Lys Glu Gln Asp Glu Asn Arg Lys Lys Asn Glu 
1               5                   10                  15      


Thr Ala Ile Arg Gln Leu Met Glu Tyr Gly Leu Thr Leu Asn Pro Thr 
            20                  25                  30          


Gly His Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Arg 
        35                  40                  45              


Cys Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro 
    50                  55                  60                  


Gly Tyr Val Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp 
65                  70                  75                  80  


Asp Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Arg Glu Asn Arg Glu 
                85                  90                  95      


Lys Gly Asn Arg Ile Pro Ala Glu Tyr Leu Gly Val Gly Thr Glu Arg 
            100                 105                 110         


Trp Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys 
        115                 120                 125             


Lys Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu 
    130                 135                 140                 


Thr Glu Phe Lys Asn Arg Asn 
145                 150     


<210>  137
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  137

Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe Phe Ala Asn Phe Ile Arg 
1               5                   10                  15      


Glu His Leu Lys Phe Ala Glu Ser Asp Asp Lys Gln Lys Val Tyr Thr 
            20                  25                  30          


Val Asn Gly Arg Val Thr Ala His Leu Arg Ser Arg Trp Glu Phe Asn 
        35                  40                  45              


Lys Asn Arg Glu Glu Ser Asp Leu His His Ala Val Asp Ala Val Ile 
    50                  55                  60                  


Val Ala Cys Thr Thr Pro Ser Asp Ile Ala Lys Val Thr Ala Phe Tyr 
65                  70                  75                  80  


Gln Arg Arg Glu Gln Asn Lys Glu Leu Ala Lys Lys Thr Glu Pro His 
                85                  90                  95      


Phe Pro Gln Pro Trp Pro His Phe Ala Asp Glu Leu Arg Ala Arg Leu 
            100                 105                 110         


Ser Lys His Pro Lys Glu Ser Ile Lys Ala Leu Asn Leu Gly Asn Tyr 
        115                 120                 125             


Asp Asp Gln Lys Leu Glu Ser Leu Gln Pro Val Phe Val Ser Arg Met 
    130                 135                 140                 


Pro Lys Arg Ser Val Thr Gly Ala Ala His Gln Glu Thr Leu Arg Arg 
145                 150                 155                 160 


Tyr Val Gly Ile Asp Glu Arg Ser 
                165             


<210>  138
<211>  257
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  138

Gly Lys Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu 
1               5                   10                  15      


Asp Ala Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg 
            20                  25                  30          


Thr Tyr Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro 
        35                  40                  45              


Lys Lys Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu 
    50                  55                  60                  


Pro Gly Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln 
65                  70                  75                  80  


Val Ile Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile 
                85                  90                  95      


Val Arg Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro 
            100                 105                 110         


Val Tyr Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile 
        115                 120                 125             


Glu Pro Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr 
    130                 135                 140                 


Thr Phe Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu 
145                 150                 155                 160 


Pro Arg Glu Lys Ile Ile Lys Thr Ala Gly Gly Glu Glu Ile Lys Ile 
                165                 170                 175     


Lys Asp Leu Phe Ala Tyr Tyr Lys Thr Ile His Ser Gly Thr Ala Gly 
            180                 185                 190         


Leu Glu Leu Val Ser His Asp Cys Ser Phe Ser Leu Ser Gly Val Gly 
        195                 200                 205             


Ser Arg Thr Leu Lys Arg Phe Glu Lys Tyr Gln Val Asp Val Leu Gly 
    210                 215                 220                 


Asn Ile Tyr Lys Val Arg Gly Glu Lys Arg Val Gly Leu Ala Ser Ser 
225                 230                 235                 240 


Ala His Ser Lys Thr Gly Glu Thr Ile Arg Pro Leu Gln Ser Thr Arg 
                245                 250                 255     


Asp 
    


<210>  139
<211>  257
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  139

Gly Lys Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu 
1               5                   10                  15      


Asp Ala Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg 
            20                  25                  30          


Thr Tyr Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro 
        35                  40                  45              


Lys Lys Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu 
    50                  55                  60                  


Pro Gly Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln 
65                  70                  75                  80  


Val Ile Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile 
                85                  90                  95      


Val Arg Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro 
            100                 105                 110         


Val Tyr Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile 
        115                 120                 125             


Glu Pro Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr 
    130                 135                 140                 


Thr Phe Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu 
145                 150                 155                 160 


Pro Arg Glu Lys Thr Val Lys Thr Ala Ala Gly Glu Glu Ile Asn Val 
                165                 170                 175     


Lys Asp Val Phe Val Tyr Tyr Lys Thr Ile Asp Ser Ala Asn Gly Gly 
            180                 185                 190         


Leu Glu Leu Ile Ser His Asp His Arg Phe Ser Leu Arg Gly Val Gly 
        195                 200                 205             


Ser Arg Thr Leu Lys Arg Phe Glu Lys Tyr Gln Val Asp Val Leu Gly 
    210                 215                 220                 


Asn Ile Tyr Lys Val Arg Gly Glu Lys Arg Val Gly Leu Ala Ser Ser 
225                 230                 235                 240 


Ala His Ser Lys Pro Gly Lys Thr Ile Arg Pro Leu Gln Ser Thr Arg 
                245                 250                 255     


Asp 
    


<210>  140
<211>  82
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  140
aagggcuuuc ugccuaaggc agacugaccc gcggcguugg ggaucgccug ucgcccgcuu       60

uuggcgggca uuccccaucc uu                                                82


