                         SEQUENCE LISTING

<110>  Five Prime Therapeutics, Inc.
 
<120>  ANTI-FGFR2 ANTIBODIES IN COMBINATION WITH CHEMOTHERAPY AGENTS IN 
       CANCER TREATMENT

<130>  01134-0054-00PCT

<150>  US 62/507,053
<151>  2017-05-16

<150>  US 62/581,992
<151>  2017-11-06

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser Asn Ala Glu Val Leu 
    290                 295                 300                 


Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly Glu Tyr Ile Cys Lys 
305                 310                 315                 320 


Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu Thr Val 
                325                 330                 335     


Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser 
            340                 345                 350         


Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile 
        355                 360                 365             


Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr 
    370                 375                 380                 


Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys 
385                 390                 395                 400 


Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser 
                405                 410                 415     


Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser 
            420                 425                 430         


Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu 
        435                 440                 445             


Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly 
    450                 455                 460                 


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala 
465                 470                 475                 480 


Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val 
                485                 490                 495     


Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val 
            500                 505                 510         


Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile 
        515                 520                 525             


Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val 
    530                 535                 540                 


Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg 
545                 550                 555                 560 


Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu 
                565                 570                 575     


Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg 
            580                 585                 590         


Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala 
        595                 600                 605             


Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp 
    610                 615                 620                 


Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr 
625                 630                 635                 640 


Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
                645                 650                 655     


Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu 
            660                 665                 670         


Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro 
        675                 680                 685             


Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys 
    690                 695                 700                 


Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp 
705                 710                 715                 720 


His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp 
                725                 730                 735     


Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu 
            740                 745                 750         


Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser 
        755                 760                 765             


Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro 
    770                 775                 780                 


Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys 
785                 790                 795                 800 


Thr 
    


<210>  2
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-FGFR2b heavy chain


<220>
<221>  MISC_FEATURE
<222>  (294)..(294)
<223>  Asn297

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Pro Asp Asn Gly Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  3
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b light chain

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Ser Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  4
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b heavy chain variable region

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Pro Asp Asn Gly Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b light chain variable region

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Ser Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b heavy chain (HC) HVR1

<400>  6

Thr Tyr Asn Val His 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b HC HVR2

<400>  7

Ser Ile Tyr Pro Asp Asn Gly Asp Thr Ser Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b HC HVR3

<400>  8

Gly Asp Phe Ala Tyr 
1               5   


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b light chain (LC) HVR1

<400>  9

Lys Ala Ser Gln Gly Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b LC HVR2

<400>  10

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b LC HVR3

<400>  11

Gln Gln His Ser Thr Thr Pro Tyr Thr 
1               5                   


<210>  12
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2b N297Q heavy chain


<220>
<221>  MISC_FEATURE
<222>  (294)..(294)
<223>  N297Q

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Asn Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr Pro Asp Asn Gly Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  13
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu 
    290                 295                 300                 


Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro 
            340                 345                 350         


Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala 
        355                 360                 365             


Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys 
    370                 375                 380                 


Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg 
385                 390                 395                 400 


Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser 
                405                 410                 415     


Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser 
            420                 425                 430         


Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
        435                 440                 445             


Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys 
    450                 455                 460                 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val 
465                 470                 475                 480 


Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys 
                485                 490                 495     


Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser 
            500                 505                 510         


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
        515                 520                 525             


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
    530                 535                 540                 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro 
545                 550                 555                 560 


Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln 
                565                 570                 575     


Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly 
            580                 585                 590         


Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala 
        595                 600                 605             


Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe 
    610                 615                 620                 


Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr 
625                 630                 635                 640 


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
                645                 650                 655     


Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met 
            660                 665                 670         


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val 
        675                 680                 685             


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
    690                 695                 700                 


Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
705                 710                 715                 720 


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
                725                 730                 735     


Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser 
            740                 745                 750         


Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser 
        755                 760                 765             


Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr 
    770                 775                 780                 


Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
785                 790                 795                 800 


<210>  14
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu Glu Pro Glu Glu 
1               5                   10                  15      


Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val Tyr Val Ala Ala 
            20                  25                  30          


Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys Asp Ala Ala Val 
        35                  40                  45              


Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro Asn Asn Arg Thr 
    50                  55                  60                  


Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala Thr Pro Arg Asp 
65                  70                  75                  80  


Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val Asp Ser Glu Thr 
                85                  90                  95      


Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn 
        115                 120                 125             


Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg 
    130                 135                 140                 


Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His 
            180                 185                 190         


Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr 
        195                 200                 205             


Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His 
    210                 215                 220                 


Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val 
                245                 250                 255     


Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His 
            260                 265                 270         


Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu 
    290                 295                 300                 


Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr 
305                 310                 315                 320 


Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu 
                325                 330                 335     


Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro 
            340                 345                 350         


Asp Tyr Leu Glu 
        355     


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 heavy chain variable region

<400>  15

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Asp Phe Arg 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Ile Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Pro Asp Asp Thr Ile Ala Tyr Cys Ala Asn 
                85                  90                  95      


Phe Tyr Tyr Gly Tyr Asp Asp Tyr Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 heavy chain CDR1

<400>  16

Ser Phe Gly Val His 
1               5   


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 heavy chain CDR2

<400>  17

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Asp Phe Arg Ser 
1               5                   10                  15      


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 heavy chain CDR3

<400>  18

Phe Tyr Tyr Gly Tyr Asp Asp Tyr Val Met Asp Tyr 
1               5                   10          


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 light chain variable region

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asp Asp Leu Tyr 
                85                  90                  95      


Met Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 light chain CDR1

<400>  20

Lys Ala Ser Gln Asp Ile Lys Asn Tyr Ile Ala 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 light chain CDR2

<400>  21

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FGFR2 Gal-FR22 light chain CDR3

<400>  22

Leu Gln Tyr Asp Asp Leu Tyr Met 
1               5               


