                         SEQUENCE LISTING

<110>  Autolus Ltd
 
<120>  CELL

<130>  P112307PCT

<150>  GB 1707780.1
<151>  2017-05-15

<150>  GB 1707781.9
<151>  2017-05-15

<150>  GB 1707782.7
<151>  2017-05-15

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 Z endodomain

<400>  1

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  2
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 and CD3 Zeta endodomains

<400>  2

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
        35                  40                  45              


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
65                  70                  75                  80  


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            100                 105                 110         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        115                 120                 125             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    130                 135                 140                 


His Met Gln Ala Leu Pro Pro Arg 
145                 150         


<210>  3
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28, OX40 and CD3 Zeta endodomains

<400>  3

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  4
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD148 endodomain

<400>  4

Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu Val Ser Phe Ser Gln 
1               5                   10                  15      


Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val Glu Asn Phe Glu Ala 
            20                  25                  30          


Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe Ala Glu Glu 
        35                  40                  45              


Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro Lys Tyr Ala Ala 
    50                  55                  60                  


Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn Val Leu Pro 
65                  70                  75                  80  


Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr His Ser Thr Asp 
                85                  90                  95      


Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His Ser Lys Lys Asp 
            100                 105                 110         


Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys Asp Phe Trp 
        115                 120                 125             


Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile Met Leu Thr Lys 
    130                 135                 140                 


Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp Pro Ser Lys 
145                 150                 155                 160 


Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met Thr Ser Glu Ile 
                165                 170                 175     


Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val Lys Asn Ile Gln 
            180                 185                 190         


Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe Thr Ser Trp Pro 
        195                 200                 205             


Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile Asn Phe Arg Tyr 
    210                 215                 220                 


Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser Pro Ile Leu 
225                 230                 235                 240 


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Ile 
                245                 250                 255     


Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val Asp Val Tyr 
            260                 265                 270         


Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu Met Val Gln Thr 
        275                 280                 285             


Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu Asp Ile Val Arg 
    290                 295                 300                 


Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn Thr Thr Ala 
305                 310                 315                 320 


Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe Gly Lys Thr 
                325                 330                 335     


Asn Gly Tyr Ile Ala 
            340     


<210>  5
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD45 endodomain

<400>  5

Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys Asn Leu Asp Glu Gln 
1               5                   10                  15      


Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln Leu Met Asn Val Glu 
            20                  25                  30          


Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr Lys Arg Lys Ile Ala 
        35                  40                  45              


Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln Ser Ile Pro Arg Val 
    50                  55                  60                  


Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys Pro Phe Asn Gln Asn 
65                  70                  75                  80  


Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp Tyr Asn Arg Val Glu 
                85                  90                  95      


Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn Tyr Ile Asn Ala Ser 
            100                 105                 110         


Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr Ile Ala Ala Gln Gly 
        115                 120                 125             


Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg Met Ile Trp Glu Gln 
    130                 135                 140                 


Lys Ala Thr Val Ile Val Met Val Thr Arg Cys Glu Glu Gly Asn Arg 
145                 150                 155                 160 


Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu Glu Gly Thr Arg Ala 
                165                 170                 175     


Phe Gly Asp Val Val Val Lys Ile Asn Gln His Lys Arg Cys Pro Asp 
            180                 185                 190         


Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys Lys Glu Lys Ala Thr 
        195                 200                 205             


Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser Trp Pro Asp His Gly 
    210                 215                 220                 


Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu Arg Arg Arg Val Asn 
225                 230                 235                 240 


Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val Val His Cys Ser Ala 
                245                 250                 255     


Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile Asp Ala Met Leu Glu 
            260                 265                 270         


Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr Gly Tyr Val Val Lys 
        275                 280                 285             


Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val Glu Ala Gln Tyr Ile 
    290                 295                 300                 


Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln Phe Gly Glu Thr Glu 
305                 310                 315                 320 


Val Asn Leu Ser Glu Leu His Pro Tyr Leu His Asn Met Lys Lys Arg 
                325                 330                 335     


Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala Glu Phe Gln Arg Leu 
            340                 345                 350         


Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile Gly Asn Gln Glu Glu 
        355                 360                 365             


Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile Pro Tyr Asp Tyr Asn 
    370                 375                 380                 


Arg Val Pro Leu Lys His Glu Leu Glu Met Ser Lys Glu Ser Glu His 
385                 390                 395                 400 


Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp Ser Glu Glu Pro Ser 
                405                 410                 415     


Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr Trp Lys Pro Glu Val 
            420                 425                 430         


Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr Ile Gly Asp Phe Trp 
        435                 440                 445             


Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile Val Met Leu Thr Glu 
    450                 455                 460                 


Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln Tyr Trp Gly Glu Gly 
465                 470                 475                 480 


Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu Lys Asp Thr Asp Lys 
                485                 490                 495     


Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu Arg His Ser Lys Arg 
            500                 505                 510         


Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr Thr Asn Trp Ser Val 
        515                 520                 525             


Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile Ser Met Ile Gln Val 
    530                 535                 540                 


Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu Gly Asn Lys His 
545                 550                 555                 560 


His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp Gly Ser Gln Gln 
                565                 570                 575     


Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu Ser Ala Glu Thr 
            580                 585                 590         


Glu Glu Val Val Asp Ile Phe Gln Val Val Lys Ala Leu Arg Lys Ala 
        595                 600                 605             


Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln Phe Leu Tyr Asp 
    610                 615                 620                 


Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln Val Lys Lys Asn 
625                 630                 635                 640 


Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu Val Asp Lys Val 
                645                 650                 655     


Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala Pro Glu Lys Leu 
            660                 665                 670         


Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro Thr Ser Gly Thr 
        675                 680                 685             


Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser Pro Ala Leu Asn 
    690                 695                 700                 


Gln Gly Ser 
705         


<210>  6
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-1 phosphatase domain

<400>  6

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser Gln Lys Gly 
        275                 280                 285             


Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala Met Lys Asn 
    290                 295                 300                 


Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys Glu Asp Val 
305                 310                 315                 320 


Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys Val Lys Lys 
                325                 330                 335     


Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu Lys Arg Lys 
            340                 345                 350         


<210>  7
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SHP-2 phosphatase domain

<400>  7

Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln Gln Glu Cys Lys Leu Leu 
1               5                   10                  15      


Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu Asn Lys Asn Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Thr Arg Val Val Leu His Asp 
        35                  40                  45              


Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr Ile Asn Ala Asn Ile Ile 
    50                  55                  60                  


Met Pro Glu Phe Glu Thr Lys Cys Asn Asn Ser Lys Pro Lys Lys Ser 
65                  70                  75                  80  


Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn Thr Val Asn Asp Phe Trp 
                85                  90                  95      


Arg Met Val Phe Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Lys 
            100                 105                 110         


Glu Val Glu Arg Gly Lys Ser Lys Cys Val Lys Tyr Trp Pro Asp Glu 
        115                 120                 125             


Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg Val Arg Asn Val Lys Glu 
    130                 135                 140                 


Ser Ala Ala His Asp Tyr Thr Leu Arg Glu Leu Lys Leu Ser Lys Val 
145                 150                 155                 160 


Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu Arg Thr Val Trp Gln Tyr 
                165                 170                 175     


His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro Gly Gly 
            180                 185                 190         


Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser Ile Val 
        195                 200                 205             


Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Thr 
    210                 215                 220                 


Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg Glu Lys 
225                 230                 235                 240 


Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met Val Arg 
                245                 250                 255     


Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg Phe Ile 
            260                 265                 270         


Tyr Met Ala Val Gln His Tyr Ile Glu Thr Leu Gln Arg Arg Ile Glu 
        275                 280                 285             


Glu Glu Gln Lys Ser Lys Arg Lys Gly His Glu Tyr Thr Asn Ile Lys 
    290                 295                 300                 


Tyr Ser Leu Val Asp Gln Thr Ser Gly Asp Gln Ser Pro Leu Pro Pro 
305                 310                 315                 320 


Cys Thr Pro Thr Pro Pro Cys Ala Glu Met Arg Glu Asp Ser Ala Arg 
                325                 330                 335     


Val Tyr Glu Asn Val Gly Leu Met Gln Gln Gln Arg Ser Phe Arg 
            340                 345                 350     


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS endodomain

<400>  8

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  9
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 endodomain

<400>  9

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA endodomain

<400>  10

Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg 
1               5                   10                  15      


Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala 
            20                  25                  30          


Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr 
        35                  40                  45              


Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val 
    50                  55                  60                  


Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn 
                85                  90                  95      


Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser 
            100                 105                 110     


<210>  11
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD30 endodomain

<400>  11

His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys 
1               5                   10                  15      


Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg 
            20                  25                  30          


Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu 
        35                  40                  45              


Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr 
    50                  55                  60                  


Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp 
65                  70                  75                  80  


Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro 
                85                  90                  95      


Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile 
            100                 105                 110         


Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro 
        115                 120                 125             


Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu 
    130                 135                 140                 


Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro 
145                 150                 155                 160 


Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly 
                165                 170                 175     


Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185             


<210>  12
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GITR endodomain

<400>  12

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  13
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVEM endodomain

<400>  13

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  14
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1 endodomain

<400>  14

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      


Leu 
    


<210>  15
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDCD1 endodomain

<400>  15

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      


Leu 
    


<210>  16
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA4 endodomain

<400>  16

Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln 
1               5                   10                  15      


Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val Arg 
            20                  25                  30          


Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn Pro 
        35                  40                  45              


Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met 
    50                  55                  60                  


Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg Pro 
65                  70                  75                  80  


Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys Arg 
                85                  90                  95      


Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu 
            100                 105                 110         


Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro 
        115                 120                 125             


Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
    130                 135                 140     


<210>  17
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 endodomain

<400>  17

Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
145                 150                 155                 160 


Ile Tyr Ala Thr Leu Ala Ile His 
                165             


<210>  18
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAIR1 endodomain

<400>  18

His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu 
1               5                   10                  15      


Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu Glu 
            20                  25                  30          


Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp Arg 
        35                  40                  45              


Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala 
65                  70                  75                  80  


Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala 
                85                  90                  95      


Ala Val Ala Arg His 
            100     


<210>  19
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4 endodomain

<400>  19

Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr 
1               5                   10                  15      


Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg 
            20                  25                  30          


Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro 
        35                  40                  45              


Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    50                  55                  60          


<210>  20
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL1 endodomain

<400>  20

Gly Asn Ser Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile 
1               5                   10                  15      


Ile Pro Phe Ala Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ala 
            20                  25                  30          


Asn Lys Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg 
        35                  40                  45              


Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr 
    50                  55                  60                  


Tyr Thr Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg 
65                  70                  75                  80  


Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr 
                85                  90                  95      


Glu Leu Pro Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            100                 105                 110     


<210>  21
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL4 endodomain

<400>  21

Gly Ile Ala Arg His Leu His Ala Val Ile Arg Tyr Ser Val Ala Ile 
1               5                   10                  15      


Ile Leu Phe Thr Ile Leu Pro Phe Phe Leu Leu His Arg Trp Cys Ser 
            20                  25                  30          


Lys Lys Lys Glu Asn Ala Ala Val Met Asn Gln Glu Pro Ala Gly His 
        35                  40                  45              


Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val 
    50                  55                  60                  


Thr Tyr Ala Gln Leu Asp His Cys Ile Phe Thr Gln Arg Lys Ile Thr 
65                  70                  75                  80  


Gly Pro Ser Gln Arg Ser Lys Arg Pro Ser Thr Asp Thr Ser Val Cys 
                85                  90                  95      


Ile Glu Leu Pro Asn Ala Glu Pro Arg Ala Leu Ser Pro Ala His Glu 
            100                 105                 110         


His His Ser Gln Ala Leu Met Gly Ser Ser Arg Glu Thr Thr Ala Leu 
        115                 120                 125             


Ser Gln Thr Gln Leu Ala Ser Ser Asn Val Pro Ala Ala Gly Ile 
    130                 135                 140             


<210>  22
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL5 endodomain

<400>  22

Thr Gly Ile Arg Arg His Leu His Ile Leu Ile Gly Thr Ser Val Ala 
1               5                   10                  15      


Ile Ile Leu Phe Ile Ile Leu Phe Phe Phe Leu Leu His Cys Cys Cys 
            20                  25                  30          


Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp 
        35                  40                  45              


Arg Thr Val Asn Arg Glu Asp Ser Asp Asp Gln Asp Pro Gln Glu Val 
    50                  55                  60                  


Thr Tyr Ala Gln Leu Asp His Cys Val Phe Thr Gln Thr Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Thr Thr Met Tyr 
                85                  90                  95      


Met Glu Leu Pro Asn Ala Lys Pro Arg Ser Leu Ser Pro Ala His Lys 
            100                 105                 110         


His His Ser Gln Ala Leu Arg Gly Ser Ser Arg Glu Thr Thr Ala Leu 
        115                 120                 125             


Ser Gln Asn Arg Val Ala Ser Ser His Val Pro Ala Ala Gly Ile 
    130                 135                 140             


<210>  23
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL1 endodomain

<400>  23

Lys Asp Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile 
1               5                   10                  15      


Ile Leu Phe Ile Leu Leu Leu Phe Phe Leu Leu His Leu Trp Cys Ser 
            20                  25                  30          


Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg 
        35                  40                  45              


Thr Ala Asn Ser Glu Asp Ser Asp Glu Gln Asp Pro Glu Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg 
65                  70                  75                  80  


Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Thr Ile Leu Tyr Thr 
                85                  90                  95      


Glu Leu Pro Asn Ala Lys Pro Arg Ser Lys Val Val Ser Cys Pro 
            100                 105                 110     


<210>  24
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL3 endodomain

<400>  24

Lys Asp Pro Gly Asn Ser Arg His Leu His Val Leu Ile Gly Thr Ser 
1               5                   10                  15      


Val Val Ile Ile Pro Phe Ala Ile Leu Leu Phe Phe Leu Leu His Arg 
            20                  25                  30          


Trp Cys Ala Asn Lys Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala 
        35                  40                  45              


Gly Asn Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln 
    50                  55                  60                  


Glu Val Thr Tyr Ala Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys 
65                  70                  75                  80  


Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Thr Ser 
                85                  90                  95      


Val 
    


<210>  25
<211>  449
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  full length C-terminal Src kinase (CSK)

<400>  25

Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala Lys 
1               5                   10                  15      


Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys Gly 
            20                  25                  30          


Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr Lys 
        35                  40                  45              


Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr Val 
    50                  55                  60                  


Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met Pro 
65                  70                  75                  80  


Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu Tyr 
                85                  90                  95      


Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr Pro 
            100                 105                 110         


Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His Tyr 
        115                 120                 125             


Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val Tyr 
    130                 135                 140                 


Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala Asp 
145                 150                 155                 160 


Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr Val 
                165                 170                 175     


Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met Lys 
            180                 185                 190         


Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp Val 
        195                 200                 205             


Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile Lys 
    210                 215                 220                 


Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met Thr 
225                 230                 235                 240 


Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val Glu 
                245                 250                 255     


Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly Ser 
            260                 265                 270         


Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly Asp 
        275                 280                 285             


Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr Leu 
    290                 295                 300                 


Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
305                 310                 315                 320 


Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr Lys 
                325                 330                 335     


Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp Thr 
            340                 345                 350         


Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp Val 
        355                 360                 365             


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg Val 
    370                 375                 380                 


Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu Lys 
385                 390                 395                 400 


Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr Glu 
                405                 410                 415     


Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser Phe 
            420                 425                 430         


Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu His 
        435                 440                 445             


Leu 
    


<210>  26
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of tyrosine kinase domain of CSK

<400>  26

Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp Val Met 
1               5                   10                  15      


Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile Lys Asn 
            20                  25                  30          


Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met Thr Gln 
        35                  40                  45              


Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val Glu Glu 
    50                  55                  60                  


Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly Ser Leu 
65                  70                  75                  80  


Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly Asp Cys 
                85                  90                  95      


Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr Leu Glu 
            100                 105                 110         


Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
        115                 120                 125             


Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr Lys Glu 
    130                 135                 140                 


Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp Thr Ala 
145                 150                 155                 160 


Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp Val Trp 
                165                 170                 175     


Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg Val Pro 
            180                 185                 190         


Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu Lys Gly 
        195                 200                 205             


Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr Glu Val 
    210                 215                 220                 


Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser Phe Leu 
225                 230                 235                 240 


Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu His Leu 
                245                 250                 255     


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tobacco Etch Virus (TeV) cleavage recognition site

<400>  27

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  28
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TeV protease domain

<400>  28

Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile 
1               5                   10                  15      


Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly 
            20                  25                  30          


Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg 
        35                  40                  45              


Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val 
    50                  55                  60                  


Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met 
65                  70                  75                  80  


Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu 
                85                  90                  95      


Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr 
            100                 105                 110         


Asn Phe Gln Thr Lys Ser Met Ser Ser Met Val Ser Asp Thr Ser Cys 
        115                 120                 125             


Thr Phe Pro Ser Ser Asp Gly Ile Phe Trp Lys His Trp Ile Gln Thr 
    130                 135                 140                 


Lys Asp Gly Gln Cys Gly Ser Pro Leu Val Ser Thr Arg Asp Gly Phe 
145                 150                 155                 160 


Ile Val Gly Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr 
                165                 170                 175     


Phe Thr Ser Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu 
            180                 185                 190         


Ala Gln Gln Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu 
        195                 200                 205             


Trp Gly Gly His Lys Val Phe Met Ser Lys Pro Glu Glu Pro Phe Gln 
    210                 215                 220                 


Pro Val Lys Glu Ala Thr Gln Leu Met Asn Glu Leu Val Tyr Ser Gln 
225                 230                 235                 240 


<210>  29
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 dimerization domain

<400>  29

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  30
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type FKBP-rapamycin binding (FRB) segment of mTOR

<400>  30

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  31
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB with T to L substitution at 2098 which allows binding to 
       AP21967

<400>  31

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  32
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR with T to H substitution at 2098 and W to F 
       at residue 2101of full mTOR

<400>  32

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu His Gln Ala Phe Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  33
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR with K to P substitution at residue 2095 of 
       full mTOR

<400>  33

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Pro Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  34
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tet repressor (TetR) sequence

<400>  34

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His 
    130                 135                 


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR interacting protein (TiP) sequence

<400>  35

Met Trp Thr Trp Asn Ala Tyr Ala Phe Ala Ala Pro Ser Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, long nanotag

<400>  36

Asp Val Glu Ala Trp Leu Asp Glu Arg Val Pro Leu Val Glu Thr 
1               5                   10                  15  


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, short nanotag

<400>  37

Asp Val Glu Ala Trp Leu Gly Ala Arg 
1               5                   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, streptag

<400>  38

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, streptagII

<400>  39

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  40
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, SBP-tag

<400>  40

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, ccstreptag

<400>  41

Cys His Pro Gln Gly Pro Pro Cys 
1               5               


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin mimicking peptide, flankedccstreptag

<400>  42

Ala Glu Cys His Pro Gln Gly Pro Pro Cys Ile Glu Gly Arg Lys 
1               5                   10                  15  


<210>  43
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core streptavidin sequence

<400>  43

Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
1               5                   10                  15      


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser 
            20                  25                  30          


Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
        35                  40                  45              


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
    50                  55                  60                  


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
65                  70                  75                  80  


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
                85                  90                  95      


Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val 
            100                 105                 110         


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125     


<210>  44
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  44

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  45
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  45

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide SFGmR

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  47
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker-V5 tag-Linker sequence

<400>  47

Asp Ser Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Ala 
            20              


<210>  48
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22(2Ig) membrane proximal Ig domains

<400>  48

Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
1               5                   10                  15      


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
            20                  25                  30          


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
        35                  40                  45              


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
    50                  55                  60                  


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
65                  70                  75                  80  


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
                85                  90                  95      


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
            100                 105                 110         


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
        115                 120                 125             


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
    130                 135                 140                 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
145                 150                 155                 160 


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
                165                 170                 175     


Pro Glu Thr Ile Gly Arg Arg 
            180             


<210>  49
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 transmembrane sequence and truncated CD19 endodomain, CD19tm

<400>  49

Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly 
1               5                   10                  15      


Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg 
            20                  25                  30          


Met Thr Asp Pro Thr Arg Arg 
        35                  


<210>  50
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid Linker sequence, RL

<400>  50

Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45              


Leu Glu Ser Gly Gly Gly Ser Ala Ser Arg 
    50                  55              


<210>  51
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB domain

<400>  51

Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Leu Glu Tyr 
                85                  90                  95      


Ser Ala Ser 
            


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Foot-and-Mouth disease virus (FMDV) 2A peptide

<400>  52

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 domain sequence, FKBP12

<400>  53

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR interacting peptide, TIP

<400>  54

Met Trp Thr Trp Asn Ala Tyr Ala Phe Ala Ala Pro 
1               5                   10          


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  55

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  56
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tet repressor B protein, TetRB

<400>  56

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205         


<210>  57
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  destabilisation domain, FK506-rapamycin binding (FRB) FRBmut

<400>  57

Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu 
1               5                   10                  15      


Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu 
            20                  25                  30          


Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu 
        35                  40                  45              


Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala 
    50                  55                  60                  


Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Pro Asp Leu 
65                  70                  75                  80  


Leu Gln Ala Phe Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90                  95      


Leu Glu Tyr 
            


<210>  58
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  destabilisation domain, mutant of the FKBP12 F36V sequence

<400>  58

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  destabilisation domain, FKBP12 L106P

<400>  59

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Pro Glu 
            100                 105         


<210>  60
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  second generation anti-CD19 CAR sequence

<400>  60

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys 
        115                 120                 125             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
145                 150                 155                 160 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp Pro Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Arg Lys Lys Arg Ser Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  61

Ser Gly Gly Gly Ser Gly 
1               5       


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM conserved sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Ser, Ile, Val or Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Ile, Val or Leu

<400>  62

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


