                         SEQUENCE LISTING

<110>  Forschungszentrum Jlich GmbH
 
<120>  Pyruvatcarboxylase und fr die Pyruvatcarboxylase kodierende DNA,
        Plasmid enthaltend die DNA, sowie Mikroorganismus zur Produktion
        und Verfahren zur Herstellung von Produkten, deren Biosynthese 
       Oxalacetat als Vorstufe beinhaltet und Chromosom

<130>  PT1.2784

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  3423
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  1
atgtcgactc acacatcttc aacgcttcca gcattcaaaa agatcttggt agcaaaccgc       60

ggcgaaatcg cggtccgtgc tttccgtgca gcactcgaaa ccggtgcagc cacggtagct      120

atttaccccc gtgaagatcg gggatcattc caccgctctt ttgcttctga agctgtccgc      180

attggtaccg aaggctcacc agtcaaggcg tacctggaca tcgatgaaat tatcggtgca      240

gctaaaaaag ttaaagcaga tgccatttac ccgggatacg gcttcctgtc tgaaaatgcc      300

cagcttgccc gcgagtgtgc ggaaaacggc attactttta ttggcccaac cccagaggtt      360

cttgatctca ccggtgataa gtctcgcgcg gtaaccgccg cgaagaaggc tggtctgcca      420

gttttggcgg aatccacccc gagcaaaaac atcgatgaga tcgttaaaag cgctgaaggc      480

cagacttacc ccatctttgt gaaggcagtt gccggtggtg gcggacgcgg tatgcgtttt      540

gttgcttcac ctgatgagct tcgcaaatta gcaacagaag catctcgtga agctgaagcg      600

gctttcggcg atggcgcggt atatgtcgaa cgtgctgtga ttaaccctca gcatattgaa      660

gtgcagatcc ttggcgatca cactggagaa gttgtacacc tttatgaacg tgactgctca      720

ctgcagcgtc gtcaccaaaa agttgtcgaa attgcgccag cacagcattt ggatccagaa      780

ctgcgtgatc gcatttgtgc ggatgcagta aagttctgcc gctccattgg ttaccagggc      840

gcgggaaccg tggaattctt ggtcgatgaa aagggcaacc acgtcttcat cgaaatgaac      900

ccacgtatcc aggttgagca caccgtgact gaagaagtca ccgaggtgga cctggtgaag      960

gcgcagatgc gcttggctgc tggtgcaacc ttgaaggaat tgggtctgac ccaagataag     1020

atcaagaccc acggtgcagc actgcagtgc cgcatcacca cggaagatcc aaacaacggc     1080

ttccgcccag ataccggaac tatcaccgcg taccgctcac caggcggagc tggcgttcgt     1140

cttgacggtg cagctcagct cggtggcgaa atcaccgcac actttgactc catgctggtg     1200

aaaatgacct gccgtggttc cgactttgaa actgctgttg ctcgtgcaca gcgcgcgttg     1260

gctgagttca ccgtgtctgg tgttgcaacc aacattggtt tcttgcgtgc gttgctgcgg     1320

gaagaggact tcacttccaa gcgcatcgcc accggattca ttgccgatca cccgcacctc     1380

cttcaggctc cacctgctga tgatgagcag ggacgcatcc tggattactt ggcagatgtc     1440

accgtgaaca agcctcatgg tgtgcgtcca aaggatgttg cagctcctat cgataagctg     1500

cctaacatca aggatctgcc actgccacgc ggttcccgtg accgcctgaa gcagcttggc     1560

ccagccgcgt ttgctcgtga tctccgtgag caggacgcac tggcagttac tgataccacc     1620

ttccgcgatg cacaccagtc tttgcttgcg acccgagtcc gctcattcgc actgaagcct     1680

gcggcagagg ccgtcgcaaa gctgactcct gagcttttgt ccgtggaggc ctggggcggc     1740

gcgacctacg atgtggcgat gcgtttcctc tttgaggatc cgtgggacag gctcgacgag     1800

ctgcgcgagg cgatgccgaa tgtaaacatt cagatgctgc ttcgcggccg caacaccgtg     1860

ggatacaccc cgtacccaga ctccgtctgc cgcgcgtttg ttaaggaagc tgccagctcc     1920

ggcgtggaca tcttccgcat cttcgacgcg cttaacgacg tctcccagat gcgtccagca     1980

atcgacgcag tcctggagac caacaccgcg gtagccgagg tggctatggc ttattctggt     2040

gatctctctg atccaaatga aaagctctac accctggatt actacctaaa gatggcagag     2100

gagatcgtca agtctggcgc tcacatcttg gccattaagg atatggctgg tctgcttcgc     2160

ccagctgcgg taaccaagct ggtcaccgca ctgcgccgtg aattcgatct gccagtgcac     2220

gtgcacaccc acgacactgc gggtggccag ctggcaacct actttgctgc agctcaagct     2280

ggtgcagatg ctgttgacgg tgcttccgca ccactgtctg gcaccacctc ccagccatcc     2340

ctgtctgcca ttgttgctgc attcgcgcac acccgtcgcg ataccggttt gagcctcgag     2400

gctgtttctg acctcgagcc gtactgggaa gcagtgcgcg gactgtacct gccatttgag     2460

tctggaaccc caggcccaac cggtcgcgtc taccgccacg aaatcccagg cggacagttg     2520

tccaacctgc gtgcacaggc caccgcactg ggccttgcgg atcgtttcga actcatcgaa     2580

gacaactacg cagccgttaa tgagatgctg ggacgcccaa ccaaggtcac cccatcctcc     2640

aaggttgttg gcgacctcgc actccacctc gttggtgcgg gtgtggatcc agcagacttt     2700

gctgccgatc cacaaaagta cgacatccca gactctgtca tcgcgttcct gcgcggcgag     2760

cttggtaacc ctccaggtgg ctggccagag ccactgcgca cccgcgcact ggaaggccgc     2820

tccgaaggca aggcacctct gacggaagtt cctgaggaag agcaggcgca cctcgacgct     2880

gatgattcca aggaacgtcg caatagcctc aaccgcctgc tgttcccgaa gccaaccgaa     2940

gagttcctcg agcaccgtcg ccgcttcggc aacacctctg cgctggatga tcgtgaattc     3000

ttctacggcc tggtcgaagg ccgcgagact ttgagccgcc tgccagatgt gcgcacccca     3060

ctgcttgttc gcctggatgc gatctctgag ccagacgata agggtatgcg caatgttgtg     3120

gccaacgtca acggccagat ccgcccaatg cgtgtgcgtg accgctccgt tgagtctgtc     3180

accgcaaccg cagaaaaggc agattcctcc aacaagggcc atgttgctgc accattcgct     3240

ggtgttgtca ccgtgactgt tgctgaaggt gatgaggtca aggctggaga tgcagtcgca     3300

atcatcgagg ctatgaagat ggaagcaaca atcactgctt ctgttgacgg caaaatcgat     3360

cgcgttgtgg ttcctgctgc aacgaaggtg gaaggtggcg acttgatcgt cgtcgtttcc     3420

taa                                                                   3423


<210>  2
<211>  1140
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  2

Met Ser Thr His Thr Ser Ser Thr Leu Pro Ala Phe Lys Lys Ile Leu 
1               5                   10                  15      


Val Ala Asn Arg Gly Glu Ile Ala Val Arg Ala Phe Arg Ala Ala Leu 
            20                  25                  30          


Glu Thr Gly Ala Ala Thr Val Ala Ile Tyr Pro Arg Glu Asp Arg Gly 
        35                  40                  45              


Ser Phe His Arg Ser Phe Ala Ser Glu Ala Val Arg Ile Gly Thr Glu 
    50                  55                  60                  


Gly Ser Pro Val Lys Ala Tyr Leu Asp Ile Asp Glu Ile Ile Gly Ala 
65                  70                  75                  80  


Ala Lys Lys Val Lys Ala Asp Ala Ile Tyr Pro Gly Tyr Gly Phe Leu 
                85                  90                  95      


Ser Glu Asn Ala Gln Leu Ala Arg Glu Cys Ala Glu Asn Gly Ile Thr 
            100                 105                 110         


Phe Ile Gly Pro Thr Pro Glu Val Leu Asp Leu Thr Gly Asp Lys Ser 
        115                 120                 125             


Arg Ala Val Thr Ala Ala Lys Lys Ala Gly Leu Pro Val Leu Ala Glu 
    130                 135                 140                 


Ser Thr Pro Ser Lys Asn Ile Asp Glu Ile Val Lys Ser Ala Glu Gly 
145                 150                 155                 160 


Gln Thr Tyr Pro Ile Phe Val Lys Ala Val Ala Gly Gly Gly Gly Arg 
                165                 170                 175     


Gly Met Arg Phe Val Ala Ser Pro Asp Glu Leu Arg Lys Leu Ala Thr 
            180                 185                 190         


Glu Ala Ser Arg Glu Ala Glu Ala Ala Phe Gly Asp Gly Ala Val Tyr 
        195                 200                 205             


Val Glu Arg Ala Val Ile Asn Pro Gln His Ile Glu Val Gln Ile Leu 
    210                 215                 220                 


Gly Asp His Thr Gly Glu Val Val His Leu Tyr Glu Arg Asp Cys Ser 
225                 230                 235                 240 


Leu Gln Arg Arg His Gln Lys Val Val Glu Ile Ala Pro Ala Gln His 
                245                 250                 255     


Leu Asp Pro Glu Leu Arg Asp Arg Ile Cys Ala Asp Ala Val Lys Phe 
            260                 265                 270         


Cys Arg Ser Ile Gly Tyr Gln Gly Ala Gly Thr Val Glu Phe Leu Val 
        275                 280                 285             


Asp Glu Lys Gly Asn His Val Phe Ile Glu Met Asn Pro Arg Ile Gln 
    290                 295                 300                 


Val Glu His Thr Val Thr Glu Glu Val Thr Glu Val Asp Leu Val Lys 
305                 310                 315                 320 


Ala Gln Met Arg Leu Ala Ala Gly Ala Thr Leu Lys Glu Leu Gly Leu 
                325                 330                 335     


Thr Gln Asp Lys Ile Lys Thr His Gly Ala Ala Leu Gln Cys Arg Ile 
            340                 345                 350         


Thr Thr Glu Asp Pro Asn Asn Gly Phe Arg Pro Asp Thr Gly Thr Ile 
        355                 360                 365             


Thr Ala Tyr Arg Ser Pro Gly Gly Ala Gly Val Arg Leu Asp Gly Ala 
    370                 375                 380                 


Ala Gln Leu Gly Gly Glu Ile Thr Ala His Phe Asp Ser Met Leu Val 
385                 390                 395                 400 


Lys Met Thr Cys Arg Gly Ser Asp Phe Glu Thr Ala Val Ala Arg Ala 
                405                 410                 415     


Gln Arg Ala Leu Ala Glu Phe Thr Val Ser Gly Val Ala Thr Asn Ile 
            420                 425                 430         


Gly Phe Leu Arg Ala Leu Leu Arg Glu Glu Asp Phe Thr Ser Lys Arg 
        435                 440                 445             


Ile Ala Thr Gly Phe Ile Ala Asp His Pro His Leu Leu Gln Ala Pro 
    450                 455                 460                 


Pro Ala Asp Asp Glu Gln Gly Arg Ile Leu Asp Tyr Leu Ala Asp Val 
465                 470                 475                 480 


Thr Val Asn Lys Pro His Gly Val Arg Pro Lys Asp Val Ala Ala Pro 
                485                 490                 495     


Ile Asp Lys Leu Pro Asn Ile Lys Asp Leu Pro Leu Pro Arg Gly Ser 
            500                 505                 510         


Arg Asp Arg Leu Lys Gln Leu Gly Pro Ala Ala Phe Ala Arg Asp Leu 
        515                 520                 525             


Arg Glu Gln Asp Ala Leu Ala Val Thr Asp Thr Thr Phe Arg Asp Ala 
    530                 535                 540                 


His Gln Ser Leu Leu Ala Thr Arg Val Arg Ser Phe Ala Leu Lys Pro 
545                 550                 555                 560 


Ala Ala Glu Ala Val Ala Lys Leu Thr Pro Glu Leu Leu Ser Val Glu 
                565                 570                 575     


Ala Trp Gly Gly Ala Thr Tyr Asp Val Ala Met Arg Phe Leu Phe Glu 
            580                 585                 590         


Asp Pro Trp Asp Arg Leu Asp Glu Leu Arg Glu Ala Met Pro Asn Val 
        595                 600                 605             


Asn Ile Gln Met Leu Leu Arg Gly Arg Asn Thr Val Gly Tyr Thr Pro 
    610                 615                 620                 


Tyr Pro Asp Ser Val Cys Arg Ala Phe Val Lys Glu Ala Ala Ser Ser 
625                 630                 635                 640 


Gly Val Asp Ile Phe Arg Ile Phe Asp Ala Leu Asn Asp Val Ser Gln 
                645                 650                 655     


Met Arg Pro Ala Ile Asp Ala Val Leu Glu Thr Asn Thr Ala Val Ala 
            660                 665                 670         


Glu Val Ala Met Ala Tyr Ser Gly Asp Leu Ser Asp Pro Asn Glu Lys 
        675                 680                 685             


Leu Tyr Thr Leu Asp Tyr Tyr Leu Lys Met Ala Glu Glu Ile Val Lys 
    690                 695                 700                 


Ser Gly Ala His Ile Leu Ala Ile Lys Asp Met Ala Gly Leu Leu Arg 
705                 710                 715                 720 


Pro Ala Ala Val Thr Lys Leu Val Thr Ala Leu Arg Arg Glu Phe Asp 
                725                 730                 735     


Leu Pro Val His Val His Thr His Asp Thr Ala Gly Gly Gln Leu Ala 
            740                 745                 750         


Thr Tyr Phe Ala Ala Ala Gln Ala Gly Ala Asp Ala Val Asp Gly Ala 
        755                 760                 765             


Ser Ala Pro Leu Ser Gly Thr Thr Ser Gln Pro Ser Leu Ser Ala Ile 
    770                 775                 780                 


Val Ala Ala Phe Ala His Thr Arg Arg Asp Thr Gly Leu Ser Leu Glu 
785                 790                 795                 800 


Ala Val Ser Asp Leu Glu Pro Tyr Trp Glu Ala Val Arg Gly Leu Tyr 
                805                 810                 815     


Leu Pro Phe Glu Ser Gly Thr Pro Gly Pro Thr Gly Arg Val Tyr Arg 
            820                 825                 830         


His Glu Ile Pro Gly Gly Gln Leu Ser Asn Leu Arg Ala Gln Ala Thr 
        835                 840                 845             


Ala Leu Gly Leu Ala Asp Arg Phe Glu Leu Ile Glu Asp Asn Tyr Ala 
    850                 855                 860                 


Ala Val Asn Glu Met Leu Gly Arg Pro Thr Lys Val Thr Pro Ser Ser 
865                 870                 875                 880 


Lys Val Val Gly Asp Leu Ala Leu His Leu Val Gly Ala Gly Val Asp 
                885                 890                 895     


Pro Ala Asp Phe Ala Ala Asp Pro Gln Lys Tyr Asp Ile Pro Asp Ser 
            900                 905                 910         


Val Ile Ala Phe Leu Arg Gly Glu Leu Gly Asn Pro Pro Gly Gly Trp 
        915                 920                 925             


Pro Glu Pro Leu Arg Thr Arg Ala Leu Glu Gly Arg Ser Glu Gly Lys 
    930                 935                 940                 


Ala Pro Leu Thr Glu Val Pro Glu Glu Glu Gln Ala His Leu Asp Ala 
945                 950                 955                 960 


Asp Asp Ser Lys Glu Arg Arg Asn Ser Leu Asn Arg Leu Leu Phe Pro 
                965                 970                 975     


Lys Pro Thr Glu Glu Phe Leu Glu His Arg Arg Arg Phe Gly Asn Thr 
            980                 985                 990         


Ser Ala Leu Asp Asp Arg Glu Phe  Phe Tyr Gly Leu Val  Glu Gly Arg 
        995                 1000                 1005             


Glu Thr  Leu Ser Arg Leu Pro  Asp Val Arg Thr Pro  Leu Leu Val 
    1010                 1015                 1020             


Arg Leu  Asp Ala Ile Ser Glu  Pro Asp Asp Lys Gly  Met Arg Asn 
    1025                 1030                 1035             


Val Val  Ala Asn Val Asn Gly  Gln Ile Arg Pro Met  Arg Val Arg 
    1040                 1045                 1050             


Asp Arg  Ser Val Glu Ser Val  Thr Ala Thr Ala Glu  Lys Ala Asp 
    1055                 1060                 1065             


Ser Ser  Asn Lys Gly His Val  Ala Ala Pro Phe Ala  Gly Val Val 
    1070                 1075                 1080             


Thr Val  Thr Val Ala Glu Gly  Asp Glu Val Lys Ala  Gly Asp Ala 
    1085                 1090                 1095             


Val Ala  Ile Ile Glu Ala Met  Lys Met Glu Ala Thr  Ile Thr Ala 
    1100                 1105                 1110             


Ser Val  Asp Gly Lys Ile Asp  Arg Val Val Val Pro  Ala Ala Thr 
    1115                 1120                 1125             


Lys Val  Glu Gly Gly Asp Leu  Ile Val Val Val Ser  
    1130                 1135                 1140 


<210>  3
<211>  3423
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  3
atgtcgactc acacatcttc aacgcttcca gcattcaaaa agatcttggt agcaaaccgc       60

ggcgaaatcg cggtccgtgc tttccgtgca gcactcgaaa ccggtgcagc cacggtagct      120

atttaccccc gtgaagatcg gggatcattc caccgctctt ttgcttctga agctgtccgc      180

attggtaccg aaggctcacc agtcaaggcg tacctggaca tcgatgaaat tatcggtgca      240

gctaaaaaag ttaaagcaga tgccatttac ccgggatacg gcttcctgtc tgaaaatgcc      300

cagcttgccc gcgagtgtgc ggaaaacggc attactttta ttggcccaac cccagaggtt      360

cttgatctca ccggtgataa gtctcgcgcg gtaaccgccg cgaagaaggc tggtctgcca      420

gttttggcgg aatccacccc gagcaaaaac atcgatgaga tcgttaaaag cgctgaaggc      480

cagacttacc ccatctttgt gaaggcagtt gccggtggtg gcggacgcgg tatgcgtttt      540

gttgcttcac ctgatgagct tcgcaaatta gcaacagaag catctcgtga agctgaagcg      600

gctttcggcg atggcgcggt atatgtcgaa cgtgctgtga ttaaccctca gcatattgaa      660

gtgcagatcc ttggcgatca cactggagaa gttgtacacc tttatgaacg tgactgctca      720

ctgcagcgtc gtcaccaaaa agttgtcgaa attgcgccag cacagcattt ggatccagaa      780

ctgcgtgatc gcatttgtgc ggatgcagta aagttctgcc gctccattgg ttaccagggc      840

gcgggaaccg tggaattctt ggtcgatgaa aagggcaacc acgtcttcat cgaaatgaac      900

ccacgtatcc aggttgagca caccgtgact gaagaagtca ccgaggtgga cctggtgaag      960

gcgcagatgc gcttggctgc tggtgcaacc ttgaaggaat tgggtctgac ccaagataag     1020

atcaagaccc acggtgcagc actgcagtgc cgcatcacca cggaagatcc aaacaacggc     1080

ttccgcccag ataccggaac tatcaccgcg taccgctcac caggcggagc tggcgttcgt     1140

cttgacggtg cagctcagct cggtggcgaa atcaccgcac actttgactc catgctggtg     1200

aaaatgacct gccgtggttc cgactttgaa actgctgttg ctcgtgcaca gcgcgcgttg     1260

gctgagttca ccgtgtctgg tgttgcaacc aacattggtt tcttgcgtgc gttgctgcgg     1320

gaagaggact tcacttccaa gcgcatcgcc accggattca ttgccgatca cccgcacctc     1380

cttcaggctc cacctgctga tgatgagcag ggacgcatcc tggattactt ggcagatgtc     1440

accgtgaaca agcctcatgg tgtgcgtcca aaggatgttg cagctcctat cgataagctg     1500

cctaacatca aggatctgcc actgccacgc ggttcccgtg accgcctgaa gcagcttggc     1560

ccagccgcgt ttgctcgtga tctccgtgag caggacgcac tggcagttac tgataccacc     1620

ttccgcgatg cacaccagtc tttgcttgcg acccgagtcc gctcattcgc actgaagcct     1680

gcggcagagg ccgtcgcaaa gctgactcct gagcttttgt ccgtggaggc ctggggcggc     1740

gcgacctacg atgtggcgat gcgtttcctc tttgaggatc cgtgggacag gctcgacgag     1800

ctgcgcgagg cgatgccgaa tgtaaacatt cagatgctgc ttcgcggccg caacaccgtg     1860

ggatacaccc cgtacccaga ctccgtctgc cgcgcgtttg ttaaggaagc tgccagctcc     1920

ggcgtggaca tcttccgcat cttcgacgcg cttaacgacg tctcccagat gcgtccagca     1980

atcgacgcag tcctggagac caacaccgcg gtagccgagg tggctatggc ttattctggt     2040

gatctctctg atccaaatga aaagctctac accctggatt actacctaaa gatggcagag     2100

gagatcgtca agtctggcgc tcacatcttg gccattaagg atatggctgg tctgcttcgc     2160

ccagctgcgg taaccaagct ggtcaccgca ctgcgccgtg aattcgatct gccagtgcac     2220

gtgcacaccc acgacactgc gggtggccag ctggcaacct actttgctgc agctcaagct     2280

ggtgcagatg ctgttgacgg tgcttccgca ccactgtctg gcaccacctc ccagccatcc     2340

ctgtctgcca ttgttgctgc attcgcgcac acccgtcgcg ataccggttt gagcctcgag     2400

gctgtttctg acctcgagcc gtactgggaa gcagtgcgcg gactgtacct gccatttgag     2460

tctggaaccc caggcccaac cggtcgcgtc taccgccacg aaatcccagg cggacagttg     2520

tccaacctgc gtgcacaggc caccgcactg ggccttgcgg atcgtttcga actcatcgaa     2580

gacaactacg cagccgttaa tgagatgctg ggacgcccaa ccaaggtcac cccatcctcc     2640

aaggttgttg gcgacctcgc actccacctc gttggtgcgg gtgtggatcc agcagacttt     2700

gctgccgatc cacaaaagta cgacatccca gactctgtca tcgcgttcct gcgcggcgag     2760

cttggtaacc ctccaggtgg ctggccagag ccactgcgca cccgcgcact ggaaggccgc     2820

tccgaaggca aggcacctct gacggaagtt cctgaggaag agcaggcgca cctcgacgct     2880

gatgattcca aggaacgtcg caatagcctc aaccgcctgc tgttcccgaa gccaaccgaa     2940

gagttcctcg agcaccgtcg ccgcttcggc aacacctctg cgctggatga tcgtgaattc     3000

ttctacggcc tggtcgaagg ccgcgagact ttgatccgcc tgccagatgt gcgcacccca     3060

ctgcttgttc gcctggatgc gatctctgag ccagacgata agggtatgcg caatgttgtg     3120

gccaacgtca acggccagat ccgcccaatg cgtgtgcgtg accgctccgt tgagtctgtc     3180

accgcaaccg cagaaaaggc agattcctcc aacaagggcc atgttgctgc accattcgct     3240

ggtgttgtca ccgtgactgt tgctgaaggt gatgaggtca aggctggaga tgcagtcgca     3300

atcatcgagg ctatgaagat ggaagcaaca atcactgctt ctgttgacgg caaaatcgat     3360

cgcgttgtgg ttcctgctgc aacgaaggtg gaaggtggcg acttgatcgt cgtcgtttcc     3420

taa                                                                   3423


<210>  4
<211>  1140
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  4

Met Ser Thr His Thr Ser Ser Thr Leu Pro Ala Phe Lys Lys Ile Leu 
1               5                   10                  15      


Val Ala Asn Arg Gly Glu Ile Ala Val Arg Ala Phe Arg Ala Ala Leu 
            20                  25                  30          


Glu Thr Gly Ala Ala Thr Val Ala Ile Tyr Pro Arg Glu Asp Arg Gly 
        35                  40                  45              


Ser Phe His Arg Ser Phe Ala Ser Glu Ala Val Arg Ile Gly Thr Glu 
    50                  55                  60                  


Gly Ser Pro Val Lys Ala Tyr Leu Asp Ile Asp Glu Ile Ile Gly Ala 
65                  70                  75                  80  


Ala Lys Lys Val Lys Ala Asp Ala Ile Tyr Pro Gly Tyr Gly Phe Leu 
                85                  90                  95      


Ser Glu Asn Ala Gln Leu Ala Arg Glu Cys Ala Glu Asn Gly Ile Thr 
            100                 105                 110         


Phe Ile Gly Pro Thr Pro Glu Val Leu Asp Leu Thr Gly Asp Lys Ser 
        115                 120                 125             


Arg Ala Val Thr Ala Ala Lys Lys Ala Gly Leu Pro Val Leu Ala Glu 
    130                 135                 140                 


Ser Thr Pro Ser Lys Asn Ile Asp Glu Ile Val Lys Ser Ala Glu Gly 
145                 150                 155                 160 


Gln Thr Tyr Pro Ile Phe Val Lys Ala Val Ala Gly Gly Gly Gly Arg 
                165                 170                 175     


Gly Met Arg Phe Val Ala Ser Pro Asp Glu Leu Arg Lys Leu Ala Thr 
            180                 185                 190         


Glu Ala Ser Arg Glu Ala Glu Ala Ala Phe Gly Asp Gly Ala Val Tyr 
        195                 200                 205             


Val Glu Arg Ala Val Ile Asn Pro Gln His Ile Glu Val Gln Ile Leu 
    210                 215                 220                 


Gly Asp His Thr Gly Glu Val Val His Leu Tyr Glu Arg Asp Cys Ser 
225                 230                 235                 240 


Leu Gln Arg Arg His Gln Lys Val Val Glu Ile Ala Pro Ala Gln His 
                245                 250                 255     


Leu Asp Pro Glu Leu Arg Asp Arg Ile Cys Ala Asp Ala Val Lys Phe 
            260                 265                 270         


Cys Arg Ser Ile Gly Tyr Gln Gly Ala Gly Thr Val Glu Phe Leu Val 
        275                 280                 285             


Asp Glu Lys Gly Asn His Val Phe Ile Glu Met Asn Pro Arg Ile Gln 
    290                 295                 300                 


Val Glu His Thr Val Thr Glu Glu Val Thr Glu Val Asp Leu Val Lys 
305                 310                 315                 320 


Ala Gln Met Arg Leu Ala Ala Gly Ala Thr Leu Lys Glu Leu Gly Leu 
                325                 330                 335     


Thr Gln Asp Lys Ile Lys Thr His Gly Ala Ala Leu Gln Cys Arg Ile 
            340                 345                 350         


Thr Thr Glu Asp Pro Asn Asn Gly Phe Arg Pro Asp Thr Gly Thr Ile 
        355                 360                 365             


Thr Ala Tyr Arg Ser Pro Gly Gly Ala Gly Val Arg Leu Asp Gly Ala 
    370                 375                 380                 


Ala Gln Leu Gly Gly Glu Ile Thr Ala His Phe Asp Ser Met Leu Val 
385                 390                 395                 400 


Lys Met Thr Cys Arg Gly Ser Asp Phe Glu Thr Ala Val Ala Arg Ala 
                405                 410                 415     


Gln Arg Ala Leu Ala Glu Phe Thr Val Ser Gly Val Ala Thr Asn Ile 
            420                 425                 430         


Gly Phe Leu Arg Ala Leu Leu Arg Glu Glu Asp Phe Thr Ser Lys Arg 
        435                 440                 445             


Ile Ala Thr Gly Phe Ile Ala Asp His Pro His Leu Leu Gln Ala Pro 
    450                 455                 460                 


Pro Ala Asp Asp Glu Gln Gly Arg Ile Leu Asp Tyr Leu Ala Asp Val 
465                 470                 475                 480 


Thr Val Asn Lys Pro His Gly Val Arg Pro Lys Asp Val Ala Ala Pro 
                485                 490                 495     


Ile Asp Lys Leu Pro Asn Ile Lys Asp Leu Pro Leu Pro Arg Gly Ser 
            500                 505                 510         


Arg Asp Arg Leu Lys Gln Leu Gly Pro Ala Ala Phe Ala Arg Asp Leu 
        515                 520                 525             


Arg Glu Gln Asp Ala Leu Ala Val Thr Asp Thr Thr Phe Arg Asp Ala 
    530                 535                 540                 


His Gln Ser Leu Leu Ala Thr Arg Val Arg Ser Phe Ala Leu Lys Pro 
545                 550                 555                 560 


Ala Ala Glu Ala Val Ala Lys Leu Thr Pro Glu Leu Leu Ser Val Glu 
                565                 570                 575     


Ala Trp Gly Gly Ala Thr Tyr Asp Val Ala Met Arg Phe Leu Phe Glu 
            580                 585                 590         


Asp Pro Trp Asp Arg Leu Asp Glu Leu Arg Glu Ala Met Pro Asn Val 
        595                 600                 605             


Asn Ile Gln Met Leu Leu Arg Gly Arg Asn Thr Val Gly Tyr Thr Pro 
    610                 615                 620                 


Tyr Pro Asp Ser Val Cys Arg Ala Phe Val Lys Glu Ala Ala Ser Ser 
625                 630                 635                 640 


Gly Val Asp Ile Phe Arg Ile Phe Asp Ala Leu Asn Asp Val Ser Gln 
                645                 650                 655     


Met Arg Pro Ala Ile Asp Ala Val Leu Glu Thr Asn Thr Ala Val Ala 
            660                 665                 670         


Glu Val Ala Met Ala Tyr Ser Gly Asp Leu Ser Asp Pro Asn Glu Lys 
        675                 680                 685             


Leu Tyr Thr Leu Asp Tyr Tyr Leu Lys Met Ala Glu Glu Ile Val Lys 
    690                 695                 700                 


Ser Gly Ala His Ile Leu Ala Ile Lys Asp Met Ala Gly Leu Leu Arg 
705                 710                 715                 720 


Pro Ala Ala Val Thr Lys Leu Val Thr Ala Leu Arg Arg Glu Phe Asp 
                725                 730                 735     


Leu Pro Val His Val His Thr His Asp Thr Ala Gly Gly Gln Leu Ala 
            740                 745                 750         


Thr Tyr Phe Ala Ala Ala Gln Ala Gly Ala Asp Ala Val Asp Gly Ala 
        755                 760                 765             


Ser Ala Pro Leu Ser Gly Thr Thr Ser Gln Pro Ser Leu Ser Ala Ile 
    770                 775                 780                 


Val Ala Ala Phe Ala His Thr Arg Arg Asp Thr Gly Leu Ser Leu Glu 
785                 790                 795                 800 


Ala Val Ser Asp Leu Glu Pro Tyr Trp Glu Ala Val Arg Gly Leu Tyr 
                805                 810                 815     


Leu Pro Phe Glu Ser Gly Thr Pro Gly Pro Thr Gly Arg Val Tyr Arg 
            820                 825                 830         


His Glu Ile Pro Gly Gly Gln Leu Ser Asn Leu Arg Ala Gln Ala Thr 
        835                 840                 845             


Ala Leu Gly Leu Ala Asp Arg Phe Glu Leu Ile Glu Asp Asn Tyr Ala 
    850                 855                 860                 


Ala Val Asn Glu Met Leu Gly Arg Pro Thr Lys Val Thr Pro Ser Ser 
865                 870                 875                 880 


Lys Val Val Gly Asp Leu Ala Leu His Leu Val Gly Ala Gly Val Asp 
                885                 890                 895     


Pro Ala Asp Phe Ala Ala Asp Pro Gln Lys Tyr Asp Ile Pro Asp Ser 
            900                 905                 910         


Val Ile Ala Phe Leu Arg Gly Glu Leu Gly Asn Pro Pro Gly Gly Trp 
        915                 920                 925             


Pro Glu Pro Leu Arg Thr Arg Ala Leu Glu Gly Arg Ser Glu Gly Lys 
    930                 935                 940                 


Ala Pro Leu Thr Glu Val Pro Glu Glu Glu Gln Ala His Leu Asp Ala 
945                 950                 955                 960 


Asp Asp Ser Lys Glu Arg Arg Asn Ser Leu Asn Arg Leu Leu Phe Pro 
                965                 970                 975     


Lys Pro Thr Glu Glu Phe Leu Glu His Arg Arg Arg Phe Gly Asn Thr 
            980                 985                 990         


Ser Ala Leu Asp Asp Arg Glu Phe  Phe Tyr Gly Leu Val  Glu Gly Arg 
        995                 1000                 1005             


Glu Thr  Leu Ile Arg Leu Pro  Asp Val Arg Thr Pro  Leu Leu Val 
    1010                 1015                 1020             


Arg Leu  Asp Ala Ile Ser Glu  Pro Asp Asp Lys Gly  Met Arg Asn 
    1025                 1030                 1035             


Val Val  Ala Asn Val Asn Gly  Gln Ile Arg Pro Met  Arg Val Arg 
    1040                 1045                 1050             


Asp Arg  Ser Val Glu Ser Val  Thr Ala Thr Ala Glu  Lys Ala Asp 
    1055                 1060                 1065             


Ser Ser  Asn Lys Gly His Val  Ala Ala Pro Phe Ala  Gly Val Val 
    1070                 1075                 1080             


Thr Val  Thr Val Ala Glu Gly  Asp Glu Val Lys Ala  Gly Asp Ala 
    1085                 1090                 1095             


Val Ala  Ile Ile Glu Ala Met  Lys Met Glu Ala Thr  Ile Thr Ala 
    1100                 1105                 1110             


Ser Val  Asp Gly Lys Ile Asp  Arg Val Val Val Pro  Ala Ala Thr 
    1115                 1120                 1125             


Lys Val  Glu Gly Gly Asp Leu  Ile Val Val Val Ser  
    1130                 1135                 1140 


<210>  5
<211>  3423
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  5
atgtcgactc acacatcttc aacgcttcca gcattcaaaa agatcttggt agcaaaccgc       60

ggcgaaatcg cggtccgtgc tttccgtgca gcactcgaaa ccggtgcagc cacggtagct      120

atttaccccc gtgaagatcg gggatcattc caccgctctt ttgcttctga agctgtccgc      180

attggtaccg aaggctcacc agtcaaggcg tacctggaca tcgatgaaat tatcggtgca      240

gctaaaaaag ttaaagcaga tgccatttac ccgggatacg gcttcctgtc tgaaaatgcc      300

cagcttgccc gcgagtgtgc ggaaaacggc attactttta ttggcccaac cccagaggtt      360

cttgatctca ccggtgataa gtctcgcgcg gtaaccgccg cgaagaaggc tggtctgcca      420

gttttggcgg aatccacccc gagcaaaaac atcgatgaga tcgttaaaag cgctgaaggc      480

cagacttacc ccatctttgt gaaggcagtt gccggtggtg gcggacgcgg tatgcgtttt      540

gttgcttcac ctgatgagct tcgcaaatta gcaacagaag catctcgtga agctgaagcg      600

gctttcggcg atggcgcggt atatgtcgaa cgtgctgtga ttaaccctca gcatattgaa      660

gtgcagatcc ttggcgatca cactggagaa gttgtacacc tttatgaacg tgactgctca      720

ctgcagcgtc gtcaccaaaa agttgtcgaa attgcgccag cacagcattt ggatccagaa      780

ctgcgtgatc gcatttgtgc ggatgcagta aagttctgcc gctccattgg ttaccagggc      840

gcgggaaccg tggaattctt ggtcgatgaa aagggcaacc acgtcttcat cgaaatgaac      900

ccacgtatcc aggttgagca caccgtgact gaagaagtca ccgaggtgga cctggtgaag      960

gcgcagatgc gcttggctgc tggtgcaacc ttgaaggaat tgggtctgac ccaagataag     1020

atcaagaccc acggtgcagc actgcagtgc cgcatcacca cggaagatcc aaacaacggc     1080

ttccgcccag ataccggaac tatcaccgcg taccgctcac caggcggagc tggcgttcgt     1140

cttgacggtg cagctcagct cggtggcgaa atcaccgcac actttgactc catgctggtg     1200

aaaatgacct gccgtggttc cgactttgaa actgctgttg ctcgtgcaca gcgcgcgttg     1260

gctgagttca ccgtgtctgg tgttgcaacc aacattggtt tcttgcgtgc gttgctgcgg     1320

gaagaggact tcacttccaa gcgcatcgcc accggattca ttgccgatca cccgcacctc     1380

cttcaggctc cacctgctga tgatgagcag ggacgcatcc tggattactt ggcagatgtc     1440

accgtgaaca agcctcatgg tgtgcgtcca aaggatgttg cagctcctat cgataagctg     1500

cctaacatca aggatctgcc actgccacgc ggttcccgtg accgcctgaa gcagcttggc     1560

ccagccgcgt ttgctcgtga tctccgtgag caggacgcac tggcagttac tgataccacc     1620

ttccgcgatg cacaccagtc tttgcttgcg acccgagtcc gctcattcgc actgaagcct     1680

gcggcagagg ccgtcgcaaa gctgactcct gagcttttgt ccgtggaggc ctggggcggc     1740

gcgacctacg atgtggcgat gcgtttcctc tttgaggatc cgtgggacag gctcgacgag     1800

ctgcgcgagg cgatgccgaa tgtaaacatt cagatgctgc ttcgcggccg caacaccgtg     1860

ggatacaccc cgtacccaga ctccgtctgc cgcgcgtttg ttaaggaagc tgccagctcc     1920

ggcgtggaca tcttccgcat cttcgacgcg cttaacgacg tctcccagat gcgtccagca     1980

atcgacgcag tcctggagac caacaccgcg gtagccgagg tggctatggc ttattctggt     2040

gatctctctg atccaaatga aaagctctac accctggatt actacctaaa gatggcagag     2100

gagatcgtca agtctggcgc tcacatcttg gccattaagg atatggctgg tctgcttcgc     2160

ccagctgcgg taaccaagct ggtcaccgca ctgcgccgtg aattcgatct gccagtgcac     2220

gtgcacaccc acgacactgc gggtggccag ctggcaacct actttgctgc agctcaagct     2280

ggtgcagatg ctgttgacgg tgcttccgca ccactgtctg gcaccacctc ccagccatcc     2340

ctgtctgcca ttgttgctgc attcgcgcac acccgtcgcg ataccggttt gagcctcgag     2400

gctgtttctg acctcgagcc gtactgggaa gcagtgcgcg gactgtacct gccatttgag     2460

tctggaaccc caggcccaac cggtcgcgtc taccgccacg aaatcccagg cggacagttg     2520

tccaacctgc gtgcacaggc caccgcactg ggccttgcgg atcgtttcga actcatcgaa     2580

gacaactacg cagccgttaa tgagatgctg ggacgcccaa ccaaggtcac cccatcctcc     2640

aaggttgttg gcgacctcgc actccacctc gttggtgcgg gtgtggatcc agcagacttt     2700

gctgccgatc cacaaaagta cgacatccca gactctgtca tcgcgttcct gcgcggcgag     2760

cttggtaacc ctccaggtgg ctggccagag ccactgcgca cccgcgcact ggaaggccgc     2820

tccgaaggca aggcacctct gacggaagtt cctgaggaag agcaggcgca cctcgacgct     2880

gatgattcca aggaacgtcg caatagcctc aaccgcctgc tgttcccgaa gccaaccgaa     2940

gagttcctcg agcaccgtcg ccgcttcggc aacacctctg cgctggatga tcgtgaattc     3000

ttctacggcc tggtcgaagg ccgcgagact ttgagccggc tgccagatgt gcgcacccca     3060

ctgcttgttc gcctggatgc gatctctgag ccagacgata agggtatgcg caatgttgtg     3120

gccaacgtca acggccagat ccgcccaatg cgtgtgcgtg accgctccgt tgagtctgtc     3180

accgcaaccg cagaaaaggc agattcctcc aacaagggcc atgttgctgc accattcgct     3240

ggtgttgtca ccgtgactgt tgctgaaggt gatgaggtca aggctggaga tgcagtcgca     3300

atcatcgagg ctatgaagat ggaagcaaca atcactgctt ctgttgacgg caaaatcgat     3360

cgcgttgtgg ttcctgctgc aacgaaggtg gaaggtggcg acttgatcgt cgtcgtttcc     3420

taa                                                                   3423


