                         SEQUENCE LISTING

<110>  The Trustees Of Princeton University
 
<120>  CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC
        GENE CLUSTERS IN ACTINOMYCETE BACTERIA

<130>  PRIN-54376

<140>  PCT/US18/32340
<141>  2018-05-11

<150>  US 62/504,603
<151>  2017-05-11

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  1

Ala Ala Gly Cys Thr Thr Ala Gly Ala Cys Gly Ala Cys Cys Ala Cys 
1               5                   10                  15      


Cys Thr Thr Cys Gly Cys Cys Gly Thr Cys Thr Gly Cys 
            20                  25                  


<210>  2
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  2

Ala Ala Gly Cys Thr Thr Thr Ala Gly Ala Cys Gly Gly Ala Cys Gly 
1               5                   10                  15      


Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Cys Ala Gly Cys 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  3

Ala Ala Gly Cys Thr Thr Ala Cys Gly Ala Gly Ala Cys Cys Cys Thr 
1               5                   10                  15      


Gly Cys Gly Gly Ala Cys Cys Gly Thr Cys Thr Thr Cys Cys 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  4

Ala Ala Gly Cys Thr Thr Thr Cys Gly Thr Gly Cys Ala Cys Cys Ala 
1               5                   10                  15      


Cys Cys Thr Gly Cys Ala Cys Cys Gly Gly Cys Thr Gly Cys 
            20                  25                  30  


<210>  5
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  5

Thr Thr Cys Thr Thr Cys Gly Thr Cys Ala Ala Cys Ala Cys Cys Cys 
1               5                   10                  15      


Thr Gly Gly Thr Gly Cys Thr Gly Cys Gly Gly Cys Ala Gly Cys Ala 
            20                  25                  30          


Gly Gly Thr Gly Cys Cys Gly Gly Ala Thr Thr Cys Cys Gly Gly Gly 
        35                  40                  45              


Gly Ala Thr Cys Cys Gly Thr Cys Gly Ala Cys Cys 
    50                  55                  60  


<210>  6
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  6

Gly Ala Cys Cys Gly Gly Gly Thr Gly Gly Thr Cys Gly Gly Thr Gly 
1               5                   10                  15      


Ala Gly Gly Cys Thr Gly Ala Gly Gly Ala Thr Gly Thr Cys Gly Thr 
            20                  25                  30          


Gly Gly Gly Cys Gly Ala Thr Cys Thr Thr Gly Thr Ala Gly Gly Cys 
        35                  40                  45              


Thr Gly Gly Ala Gly Cys Thr Gly Cys Thr Thr Cys 
    50                  55                  60  


<210>  7
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  7

Ala Gly Ala Thr Cys Ala Gly Cys Cys Ala Cys Ala Cys Cys Cys Thr 
1               5                   10                  15      


Gly Ala Thr Cys Cys Cys Gly Cys Cys Gly Ala Cys Gly Gly Thr Cys 
            20                  25                  30          


Cys Thr Cys Gly Cys Cys Ala Gly Ala Thr Thr Cys Cys Gly Gly Gly 
        35                  40                  45              


Gly Ala Thr Cys Cys Gly Thr Cys Gly Ala Cys Cys 
    50                  55                  60  


<210>  8
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  8

Cys Gly Ala Gly Gly Cys Thr Gly Ala Ala Gly Ala Ala Gly Thr Thr 
1               5                   10                  15      


Gly Thr Cys Cys Cys Gly Gly Gly Thr Gly Cys Cys Gly Ala Cys Ala 
            20                  25                  30          


Cys Gly Thr Thr Cys Cys Ala Cys Cys Thr Gly Thr Ala Gly Gly Cys 
        35                  40                  45              


Thr Gly Gly Ala Gly Cys Thr Gly Cys Thr Thr Cys 
    50                  55                  60  


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  9

Ala Cys Thr Cys Thr Ala Gly Ala Cys Thr Gly Ala Ala Gly Thr Thr 
1               5                   10                  15      


Cys Thr Cys Cys Gly Gly Gly Cys Cys Cys Ala Cys Gly Ala Cys 
            20                  25                  30      


<210>  10
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  10

Gly Thr Cys Gly Thr Ala Cys Gly Gly Thr Cys Ala Cys Cys Ala Thr 
1               5                   10                  15      


Cys Cys Thr Cys Thr Ala Gly Thr Cys Ala Ala Gly Cys Thr Thr Gly 
            20                  25                  30          


Cys Ala Cys Ala Gly Cys Thr Thr Cys Ala Ala Thr Cys Thr Ala Thr 
        35                  40                  45              


Cys Thr Gly 
    50      


<210>  11
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  11

Cys Ala Ala Gly Cys Thr Thr Gly Ala Cys Thr Ala Gly Ala Gly Gly 
1               5                   10                  15      


Ala Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr Ala Cys Gly Ala Cys 
            20                  25                  30          


<210>  12
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  12

Gly Cys Thr Cys Thr Ala Gly Ala Thr Gly Cys Cys Thr Cys Gly Cys 
1               5                   10                  15      


Cys Thr Gly Cys Cys Thr Cys Ala Cys Cys Ala Gly Ala Cys Thr Cys 
            20                  25                  30          


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  13

Ala Gly Thr Ala Ala Gly Cys Thr Thr Cys Cys Ala Cys Cys Gly Ala 
1               5                   10                  15      


Cys Thr Ala Thr Thr Thr Gly Cys Ala Ala Cys Ala Gly Thr 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  14

Ala Cys Cys Ala Ala Gly Cys Thr Thr Cys Gly Gly Gly Gly Thr Cys 
1               5                   10                  15      


Ala Thr Thr Ala Thr Ala Gly Cys Gly Ala Thr Thr Thr Thr 
            20                  25                  30  


<210>  15
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  15

Ala Thr Cys Ala Thr Cys Ala Cys Gly Cys Gly Cys Gly Ala Gly Cys 
1               5                   10                  15      


Thr Gly Ala Gly Cys 
            20      


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  16

Cys Gly Ala Gly Gly Ala Cys Gly Ala Gly Gly Ala Gly Thr Thr Thr 
1               5                   10                  15      


Cys Gly 
        


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  17

Ala Gly Ala Thr Cys Ala Gly Cys Cys Ala Cys Ala Cys Cys Cys Thr 
1               5                   10                  15      


Gly Ala Thr Cys Cys 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  18

Thr Gly Ala Ala Gly Ala Ala Gly Thr Thr Gly Thr Cys Cys Cys Gly 
1               5                   10                  15      


Gly Gly Thr Gly Cys 
            20      


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  19

Gly Gly Ala Thr Cys Cys Ala Thr Cys Ala Gly Thr Gly Cys Cys Ala 
1               5                   10                  15      


Thr Gly Gly Gly Gly Ala Gly Cys Thr Thr Cys Cys 
            20                  25              


<210>  20
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  20

Thr Thr Gly Cys Thr Cys Ala Cys Cys Ala Thr Thr Gly Cys Gly Thr 
1               5                   10                  15      


Cys Cys Cys Cys Thr Gly Cys Gly Cys Cys Cys Ala Cys Thr Gly Cys 
            20                  25                  30          


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  21

Gly Ala Ala Thr Thr Cys Ala Thr Gly Thr Thr Cys Cys Ala Gly Gly 
1               5                   10                  15      


Ala Thr Gly Ala Gly Cys Gly Gly Thr Cys Gly 
            20                  25          


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  22

Ala Ala Gly Cys Thr Thr Thr Cys Cys Ala Gly Gly Ala Ala Cys Cys 
1               5                   10                  15      


Ala Gly Ala Gly Cys Cys Gly Thr Thr Cys Cys Thr Gly Cys 
            20                  25                  30  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  23

Ala Gly Gly Gly Gly Ala Cys Gly Cys Ala Ala Thr Gly Gly Thr Gly 
1               5                   10                  15      


Ala Gly Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly Gly 
            20                  25                  


<210>  24
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  24

Gly Ala Ala Thr Thr Cys Thr Cys Ala Cys Thr Thr Gly Thr Ala Cys 
1               5                   10                  15      


Ala Gly Cys Thr Cys Gly Thr Cys Cys Ala Thr Gly 
            20                  25              


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  25

Thr Thr Thr Cys Cys Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly Ala 
1               5                   10                  15      


Ala Gly Cys Thr Gly 
            20      


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  26

Thr Cys Gly Ala Gly Thr Thr Cys Gly Cys Gly Gly Thr Ala Gly Gly 
1               5                   10                  15      


Thr Cys Ala Gly Gly 
            20      


<210>  27
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  27

Thr Thr Gly Cys Thr Cys Ala Cys Cys Ala Thr Thr Gly Cys Gly Thr 
1               5                   10                  15      


Cys Cys Cys Cys Thr Gly Cys Gly Cys Cys Cys Ala Cys 
            20                  25                  


<210>  28
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  28

Ala Gly Gly Gly Gly Ala Cys Gly Cys Ala Ala Thr Gly Gly Thr Gly 
1               5                   10                  15      


Ala Gly Cys Met Gly Gly Gly Cys Gly Ala Gly Gly 
            20                  25              


<210>  29
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  29

Ala Thr Cys Ala Thr Ala Thr Gly Ala Thr Gly Gly Thr Gly Ala Gly 
1               5                   10                  15      


Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly Gly Ala Gly 
            20                  25                  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  30

Ala Ala Gly Ala Ala Thr Thr Cys Thr Cys Ala Cys Thr Thr Gly Thr 
1               5                   10                  15      


Ala Cys Ala Gly Cys Thr Cys Gly Thr Cys Cys Ala Thr Gly 
            20                  25                  30  


<210>  31
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  31

Ala Cys Ala Ala Thr Thr Gly Cys Ala Gly Cys Thr Cys Ala Ala Gly 
1               5                   10                  15      


Gly Ala Gly Gly Ala Thr Cys Cys Ala Thr Cys Ala Thr Gly Gly Thr 
            20                  25                  30          


Gly Ala Gly Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly Gly Ala Gly 
        35                  40                  45              


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  32

Ala Ala Gly Ala Ala Thr Thr Cys Thr Cys Ala Cys Thr Thr Gly Thr 
1               5                   10                  15      


Ala Cys Ala Gly Cys Thr Cys Gly Thr Cys Cys Ala Thr Gly 
            20                  25                  30  


<210>  33
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  33

Ala Thr Ala Ala Gly Cys Thr Thr Ala Thr Gly Ala Ala Cys Ala Ala 
1               5                   10                  15      


Ala Gly Gly Thr Gly Thr Ala Ala Thr Gly Cys Gly 
            20                  25              


<210>  34
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  34

Ala Ala Thr Cys Thr Ala Gly Ala Thr Cys Ala Gly Gly Thr Cys Ala 
1               5                   10                  15      


Gly Cys Ala Cys Gly Gly Thr Cys Ala Thr Gly 
            20                  25          


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  35

Gly Cys Thr Thr Cys Thr Ala Gly Ala Gly Gly Gly Cys Gly Cys Gly 
1               5                   10                  15      


Cys Thr Gly Cys Thr Cys Ala Ala Cys Gly Thr Gly Ala 
            20                  25                  


<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  36

Ala Cys Ala Ala Gly Cys Thr Thr Gly Cys Gly Thr Cys Cys Cys Cys 
1               5                   10                  15      


Thr Cys Cys Gly Cys Cys Cys Ala Gly Thr Gly Cys Ala Ala Cys 
            20                  25                  30      


<210>  37
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  37

Ala Thr Cys Ala Thr Ala Thr Gly Ala Thr Gly Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Gly Ala Gly Thr Thr Ala Thr Gly Cys Gly 
            20                  25              


<210>  38
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  38

Ala Ala Gly Ala Ala Thr Thr Cys Thr Cys Ala Gly Gly Thr Cys Ala 
1               5                   10                  15      


Gly Cys Ala Cys Gly Gly Thr Cys Ala Thr Gly 
            20                  25          


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  39

Cys Ala Ala Gly Ala Cys Cys Gly Thr Cys Ala Ala Gly Gly Thr Gly 
1               5                   10                  15      


Cys Thr Cys Thr 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  40

Gly Ala Gly Cys Cys Gly Ala Gly Ala Thr Gly Ala Thr Gly Ala Cys 
1               5                   10                  15      


Cys Thr Thr Cys 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  41

Gly Ala Gly Ala Ala Cys Thr Ala Cys Cys Cys Gly Gly Ala Cys Ala 
1               5                   10                  15      


Ala Cys Gly Ala 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  42

Gly Gly Gly Thr Cys Gly Thr Ala Gly Gly Ala Gly Ala Gly Gly Thr 
1               5                   10                  15      


Cys Cys Ala Gly 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  43

Gly Ala Cys Gly Ala Gly Ala Cys Cys Cys Thr Gly Thr Cys Thr Thr 
1               5                   10                  15      


Ala Cys Gly Cys 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  44

Ala Gly Thr Ala Cys Gly Gly Thr Cys Ala Gly Cys Cys Ala Cys Thr 
1               5                   10                  15      


Cys Gly Ala Cys 
            20  


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  45

Ala Gly Gly Thr Cys Cys Cys Gly Ala Thr Cys Thr Ala Cys Cys Ala 
1               5                   10                  15      


Gly Cys Ala 
            


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer Sequence

<400>  46

Gly Thr Ala Gly Gly Cys Cys Thr Thr Gly Thr Thr Gly Ala Cys Gly 
1               5                   10                  15      


Gly Thr Gly Thr 
            20  


