                         SEQUENCE LISTING

<110>  University of Louisville Research Foundation, Inc.
       Eaton, John W.
       Yaddanapudi, Kavitha
       Li, Chi
 
<120>  COMPOSITIONS COMPRISING ENGINEERED EMBRYONIC STEM CELL-DERIVED 
       EXOSOMES AND METHODS OF USE THEREFOR

<130>  1577/41 PCT

<150>  US 62/504132
<151>  2017-05-10

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  800
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (33)..(467)

<400>  1
acacagagag aaaggctaaa gttctctgga gg atg tgg ctg cag agc ctg ctg         53
                                    Met Trp Leu Gln Ser Leu Leu           
                                    1               5                     

ctc ttg ggc act gtg gcc tgc agc atc tct gca ccc gcc cgc tcg ccc        101
Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Ala Pro Ala Arg Ser Pro           
        10                  15                  20                        

agc ccc agc acg cag ccc tgg gag cat gtg aat gcc atc cag gag gcc        149
Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala           
    25                  30                  35                            

cgg cgt ctc ctg aac ctg agt aga gac act gct gct gag atg aat gaa        197
Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu           
40                  45                  50                  55            

aca gta gaa gtc atc tca gaa atg ttt gac ctc cag gag ccg acc tgc        245
Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys           
                60                  65                  70                

cta cag acc cgc ctg gag ctg tac aag cag ggc ctg cgg ggc agc ctc        293
Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu           
            75                  80                  85                    

acc aag ctc aag ggc ccc ttg acc atg atg gcc agc cac tac aag cag        341
Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln           
        90                  95                  100                       

cac tgc cct cca acc ccg gaa act tcc tgt gca acc cag att atc acc        389
His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr           
    105                 110                 115                           

ttt gaa agt ttc aaa gag aac ctg aag gac ttt ctg ctt gtc atc ccc        437
Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro           
120                 125                 130                 135           

ttt gac tgc tgg gag cca gtc cag gag tga gaccggccag atgaggctgg          487
Phe Asp Cys Trp Glu Pro Val Gln Glu                                       
                140                                                       

ccaagccggg gagctgctct ctcatgaaac aagagctaga aactcaggat ggtcatcttg      547

gagggaccaa ggggtgggcc acagccatgg tgggagtggc ctggacctgc cctgggccac      607

actgaccctg atacaggcat ggcagaagaa tgggaatatt ttatactgac agaaatcagt      667

aatatttata tatttatatt tttaaaatat ttatttattt atttatttaa gttcatattc      727

catatttatt caagatgttt taccgtaata attattatta aaaatatgct tctacttgaa      787

aaaaaaaaaa aaa                                                         800


<210>  2
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  3
<211>  1033
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (290)..(715)

<400>  3
ggtcagactg cccaggcagg gtgggaaagg cctttaaagc agcccgcagg tgggctgcca       60

gttcttggaa gggcttatta atgaaaaccc cccaagcctg acaacctggg ggaaggctca      120

ctggccccat gtatagctga taagggccag gagattccac aactcaggta gttcccccgc      180

ccccctggag ttctgtggtc accattaatc atttcctcta actgtgtata taagagctct      240

tttgcagtga gcccagtact cagagagaaa ggctaaggtc ctgaggagg atg tgg ctg      298
                                                      Met Trp Leu         
                                                      1                   

cag aat tta ctt ttc ctg ggc att gtg gtc tac agc ctc tca gca ccc        346
Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu Ser Ala Pro           
    5                   10                  15                            

acc cgc tca ccc atc act gtc acc cgg cct tgg aag cat gta gag gcc        394
Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala           
20                  25                  30                  35            

atc aaa gaa gcc ctg aac ctc ctg gat gac atg cct gtc acg ttg aat        442
Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn           
                40                  45                  50                

gaa gag gta gaa gtc gtc tct aac gag ttc tcc ttc aag aag cta aca        490
Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr           
            55                  60                  65                    

tgt gtg cag acc cgc ctg aag ata ttc gag cag ggt cta cgg ggc aat        538
Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn           
        70                  75                  80                        

ttc acc aaa ctc aag ggc gcc ttg aac atg aca gcc agc tac tac cag        586
Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln           
    85                  90                  95                            

aca tac tgc ccc cca act ccg gaa acg gac tgt gaa aca caa gtt acc        634
Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr           
100                 105                 110                 115           

acc tat gcg gat ttc ata gac agc ctt aaa acc ttt ctg act gat atc        682
Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile           
                120                 125                 130               

ccc ttt gaa tgc aaa aaa cca ggc caa aaa tga ggaagcccag gccagctctg      735
Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys                                   
            135                 140                                       

aatccagctt ctcagactgc tgcttttgtg cctgcgtaat gagccaggaa cttggaattt      795

ctgccttaaa gggaccaaga gatgtggcac agccacagtt ggaaggcagt atagccctct      855

gaaaacgctg actcagcttg gacagcggaa gacaaacgag agatattttc tactgatagg      915

gaccattata tttatttata tatttatatt ttttaaatat ttatttattt atttatttat      975

ttttgcaact ctatttattg agaatgtctt accagaataa taaattatta aaactttt       1033


<210>  4
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  4

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


