                               SEQUENCE LISTING

<110> ADIMAB, LLC
 
<120> HUMANIZED ANTI-CD3 ANTIBODIES

<130> 2009186-0189

<140>
<141>

<160> 6480  

<170> PatentIn version 3.5

<210> 1
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttatgtatcc tggtttgctt attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3
Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4
ttcaccttta acacatatgc catgaat                                           27


<210> 5
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 7
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210> 8
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 8
gtcaggcacg gtaacttcgg gaacagttat gtatcctggt ttgcttat                    48


<210> 9
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 9
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 10
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 10
Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 11
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 11
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 12
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 12
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 13
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 14
ggcacaaaca agcgcgctcc t                                                 21


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 15
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 16
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 16
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 17
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 17
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 18
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 19
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 20
ttcacctttg acacatatgc catgaat                                           27


<210> 21
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 21
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 22
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 22
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 23
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 24
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 24
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 25
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 25
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 26
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 26
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 27
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 27
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 28
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 28
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 29
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 30
ggcacagaca agcgcgctcc c                                                 21


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 31
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 32
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 32
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 33
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 33
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 34
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 34
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 35
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 36
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 36
ttcacctttg acacatatgc catgaat                                           27


<210> 37
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 37
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 38
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 38
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 39
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 40
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 40
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 41
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 41
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 42
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 42
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 43
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 44
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 44
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 45
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 46
ggcacaaaca agcgcgctcc t                                                 21


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 47
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 48
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 48
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 49
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 49
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgaggctc       60

tcctgtgcag cctctggatt cacctttaac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attaggtcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacgg ttatgtatcc tggtttgctt actggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 50
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 50
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 51
Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210> 52
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 52
ttcaccttta acacatatgc catgaat                                           27


<210> 53
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 53
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 54
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 54
aggattaggt ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 55
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 55
Val Arg His Ser Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210> 56
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 56
gtcaggcaca gtaacttcgg gaacggttat gtatcctggt ttgcttac                    48


<210> 57
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 57
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 58
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 58
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 59
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 59
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 60
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 60
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 61
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 62
ggcacagaca agcgcgctcc c                                                 21


<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 63
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 64
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 64
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 65
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 65
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 66
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 66
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 67
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 68
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 68
ttcacctttg acacatatgc catgaat                                           27


<210> 69
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 69
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 70
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 70
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 71
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 71
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 72
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 72
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 73
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 73
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 74
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 74
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 75
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 75
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 76
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 76
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 77
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 78
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 78
ggcacagaca agcgcgctcc c                                                 21


<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 79
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 80
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 80
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 81
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 81
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 82
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 82
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 83
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 84
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 84
ttcacctttg acacatatgc catgaat                                           27


<210> 85
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 85
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 86
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 86
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 87
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 87
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 88
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 88
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 89
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 89
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg gatccagcag      120

accccaggcc aggccccgcg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgcc tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 90
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 90
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Ile Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Leu 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 91
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 91
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 92
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 92
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 93
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 94
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 94
ggcacaaaca agcgcgctcc t                                                 21


<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 95
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 96
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 96
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 97
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 97
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccggggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctacg      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtacctgc aaataaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggagccctg      360

gtcaccgtct cctca                                                       375


<210> 98
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 98
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 99
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 100
ttcacctttg acacatatgc catgaat                                           27


<210> 101
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 101
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 102
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 102
aggattagat ccaagtataa caattacgct acgtactacg cagactccgt gaaggat          57


<210> 103
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 103
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 104
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 104
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 105
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 105
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 106
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 106
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 107
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 107
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 108
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 108
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 109
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 110
ggcacagaca agcgcgctcc c                                                 21


<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 111
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 112
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 112
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 113
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 113
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 114
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 114
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 115
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 116
ttcacctttg acacatatgc catgaat                                           27


<210> 117
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 117
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 118
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 118
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 119
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 119
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 120
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 120
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 121
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 121
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgagcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 122
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 122
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 123
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 123
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 124
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 124
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 125
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 126
ggcacagaca agcgcgctcc c                                                 21


<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 127
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 128
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 128
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 129
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 129
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 130
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 130
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 131
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 132
ttcacctttg acacatatgc catgaat                                           27


<210> 133
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 133
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 134
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 134
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 135
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 135
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 136
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 136
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 137
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 137
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgatcgct tctctggctc cctgctcggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 138
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 138
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 139
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 139
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 140
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 140
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 141
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 142
ggcacagaca agcgcgctcc c                                                 21


<210> 143
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 143
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 144
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 144
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 145
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 145
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 146
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 146
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 147
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 148
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 148
ttcacctttg acacatatgc catgaat                                           27


<210> 149
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 149
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 150
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 150
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 151
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 151
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 152
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 152
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 153
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 153
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 154
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 154
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 155
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 155
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 156
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 156
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 157
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 158
ggcacaaaca agcgcgctcc t                                                 21


<210> 159
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 159
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 160
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 160
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 161
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 161
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctctgcc acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag tcacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 162
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 162
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ala Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser His Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 163
Phe Thr Ser Ala Thr Tyr Ala Met Asn 
1               5                   


<210> 164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 164
ttcacctctg ccacatatgc catgaat                                           27


<210> 165
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 165
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 166
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 166
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 167
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 167
Val Arg His Gly Asn Phe Gly Asn Ser His Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 168
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 168
gtcaggcacg gtaacttcgg gaacagtcac gtatcctggt ttgctcat                    48


<210> 169
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 169
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 170
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 170
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 171
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 171
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 172
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 172
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 173
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 174
ggcacaaaca agcgcgctcc t                                                 21


<210> 175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 175
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 176
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 176
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 177
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 177
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagaacacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttatgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 178
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 178
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 179
Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210> 180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 180
ttcaccttta acacatatgc catgaat                                           27


<210> 181
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 181
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 182
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 182
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 183
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 183
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 184
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 184
gtcaggcacg gtaacttcgg gaacagttat gtatcctggt ttgcttct                    48


<210> 185
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 185
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac agtcacactc       60

acttgtggct caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 186
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 186
Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 187
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 187
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 188
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 188
ggctcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 189
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 190
ggcacagaca agcgcgctcc t                                                 21


<210> 191
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 191
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 192
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 192
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 193
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 193
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 194
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 194
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 195
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 196
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 196
ttcacctttg acacatatgc catgaat                                           27


<210> 197
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 197
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 198
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 198
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 199
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 199
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 200
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 200
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 201
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 201
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 202
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 202
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 203
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 203
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 204
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 204
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 205
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 206
ggcacagaca agcgcgctcc t                                                 21


<210> 207
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 207
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 208
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 208
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 209
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 209
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 210
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 210
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 211
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 212
ttcacctttg acacatatgc catgaat                                           27


<210> 213
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 213
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 214
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 214
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 215
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 215
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 216
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 216
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 217
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 217
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 218
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 218
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 219
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 219
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 220
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 220
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 221
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 222
ggcacagaca agcgcgctcc t                                                 21


<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 223
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 224
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 224
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 225
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 225
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 226
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 226
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 227
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 228
ttcacctttg acacatatgc catgaat                                           27


<210> 229
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 229
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 230
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 230
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 231
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 231
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 232
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 232
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 233
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 233
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 234
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 234
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 235
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 235
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 236
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 236
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 237
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 238
ggcacagaca agcgcgctcc t                                                 21


<210> 239
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 239
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 240
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 240
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 241
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 241
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 242
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 242
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 243
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 244
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 244
ttcacctttg acacatatgc catgaat                                           27


<210> 245
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 245
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 246
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 246
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 247
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 247
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 248
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 248
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 249
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 249
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 250
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 250
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 251
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 251
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 252
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 252
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 253
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 254
ggcacagaca agcgcgctcc t                                                 21


<210> 255
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 255
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 256
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 256
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 257
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 257
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 258
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 258
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 259
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 260
ttcacctttg acacatatgc catgaat                                           27


<210> 261
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 261
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 262
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 262
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 263
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 263
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 264
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 264
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 265
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 265
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 266
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 266
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 267
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 267
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 268
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 268
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 269
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 270
ggcacagaca agcgcgctcc t                                                 21


<210> 271
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 271
Ala Leu Trp Tyr Asn Asn His Trp Val 
1               5                   


<210> 272
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 272
gcgctgtggt acaataacca ttgggtg                                           27


<210> 273
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 273
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 274
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 274
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 275
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 276
ttcacctttg acacatatgc catgaat                                           27


<210> 277
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 277
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 278
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 278
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 279
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 279
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 280
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 280
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 281
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 281
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 282
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 282
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 283
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 283
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 284
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 284
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 285
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 286
ggcacagaca agcgcgctcc t                                                 21


<210> 287
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 287
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 288
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 288
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 289
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 289
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 290
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 290
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 291
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 292
ttcacctttg acacatatgc catgaat                                           27


<210> 293
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 293
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 294
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 294
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 295
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 295
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 296
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 296
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 297
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 297
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 298
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 298
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 299
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 299
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 300
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 300
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 301
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 302
ggcacagaca agcgcgctcc t                                                 21


<210> 303
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 303
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 304
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 304
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 305
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 305
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 306
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 306
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 307
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 308
ttcacctttg acacatatgc catgaat                                           27


<210> 309
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 309
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 310
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 310
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 311
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 311
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 312
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 312
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 313
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 313
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 314
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 314
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 315
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 315
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 316
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 316
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 317
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 318
ggcacagaca agcgcgctcc t                                                 21


<210> 319
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 319
Ala Leu Trp Tyr Asn Asn His Trp Val 
1               5                   


<210> 320
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 320
gcgctgtggt acaataacca ttgggtg                                           27


<210> 321
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 321
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 322
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 322
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 323
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 324
ttcacctttg acacatatgc catgaat                                           27


<210> 325
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 325
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 326
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 326
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 327
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 327
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 328
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 328
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 329
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 329
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 330
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 330
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 331
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 331
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 332
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 332
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 333
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 334
ggcacagaca agcgcgctcc t                                                 21


<210> 335
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 335
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 336
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 336
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 337
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 337
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 338
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 338
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 339
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 340
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 340
ttcacctttg acacatatgc catgaat                                           27


<210> 341
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 341
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 342
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 342
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 343
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 343
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 344
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 344
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 345
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 345
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 346
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 346
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 347
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 347
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 348
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 348
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 349
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 350
ggcacagaca agcgcgctcc t                                                 21


<210> 351
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 351
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 352
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 352
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 353
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 353
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 354
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 354
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 355
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 356
ttcacctttg acacatatgc catgaat                                           27


<210> 357
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 357
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 358
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 358
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 359
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 359
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 360
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 360
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 361
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 361
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 362
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 362
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 363
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 363
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 364
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 364
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 365
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 366
ggcacagaca agcgcgctcc t                                                 21


<210> 367
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 367
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 368
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 368
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 369
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 369
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 370
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 370
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 371
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 372
ttcacctttg acacatatgc catgaat                                           27


<210> 373
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 373
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 374
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 374
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 375
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 375
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 376
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 376
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 377
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 377
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 378
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 378
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 379
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 379
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 380
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 380
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 381
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 382
ggcacagaca agcgcgctcc t                                                 21


<210> 383
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 383
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 384
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 384
gcgctgtggt acaataacct ttgggtg                                           27


<210> 385
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 385
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 386
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 386
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 387
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 388
ttcacctttg acacatatgc catgaat                                           27


<210> 389
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 389
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 390
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 390
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 391
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 391
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 392
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 392
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 393
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 393
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 394
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 394
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 395
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 395
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 396
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 396
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 397
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 398
ggcacagaca agcgcgctcc t                                                 21


<210> 399
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 399
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 400
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 400
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 401
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 401
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 402
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 402
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 403
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 404
ttcacctttg acacatatgc catgaat                                           27


<210> 405
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 405
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 406
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 406
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 407
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 407
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 408
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 408
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 409
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 409
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 410
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 410
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 411
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 411
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 412
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 412
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 413
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 414
ggcacagaca agcgcgctcc t                                                 21


<210> 415
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 415
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 416
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 416
gcgctgtggt acaataacct ttgggtg                                           27


<210> 417
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 417
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 418
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 418
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 419
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 420
ttcacctttg acgcttatgc catgaat                                           27


<210> 421
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 421
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 422
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 422
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 423
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 423
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 424
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 424
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 425
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 425
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 426
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 426
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 427
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 427
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 428
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 428
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 429
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 430
ggcacagaca agcgcgctcc t                                                 21


<210> 431
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 431
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 432
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 432
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 433
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 433
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 434
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 434
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 435
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 436
ttcacctttg acacatatgc catgaat                                           27


<210> 437
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 437
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 438
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 438
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 439
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 439
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 440
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 440
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 441
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 441
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 442
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 442
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 443
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 443
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 444
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 444
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 445
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 446
ggcacagaca agcgcgctcc t                                                 21


<210> 447
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 447
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 448
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 448
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 449
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 449
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 450
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 450
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 451
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 452
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 452
ttcacctttg acacatatgc catgaat                                           27


<210> 453
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 453
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 454
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 454
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 455
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 455
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 456
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 456
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 457
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 457
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 458
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 458
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 459
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 459
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 460
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 460
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 461
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 462
ggcacagaca agcgcgctcc t                                                 21


<210> 463
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 463
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 464
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 464
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 465
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 465
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 466
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 466
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 467
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 468
ttcacctttg acacatatgc catgaat                                           27


<210> 469
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 469
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 470
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 470
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 471
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 471
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 472
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 472
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 473
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 473
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 474
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 474
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 475
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 475
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 476
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 476
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 477
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 478
ggcacagaca agcgcgctcc t                                                 21


<210> 479
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 479
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 480
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 480
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 481
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 481
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 482
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 482
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 483
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 484
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 484
ttcacctttg acacatatgc catgaat                                           27


<210> 485
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 485
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 486
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 486
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 487
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 487
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 488
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 488
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 489
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 489
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 490
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 490
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 491
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 491
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 492
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 492
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 493
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 493
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 494
ggcacagaca agcgcgctcc t                                                 21


<210> 495
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 495
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 496
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 496
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 497
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 497
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacgc tctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 498
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 498
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 499
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 499
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 500
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 500
ttcacctttg acacatatgc catgaat                                           27


<210> 501
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 501
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 502
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 502
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 503
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 503
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 504
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 504
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 505
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 505
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 506
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 506
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 507
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 507
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 508
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 508
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 509
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 509
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 510
ggcacagaca agcgcgctcc t                                                 21


<210> 511
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 511
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 512
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 512
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 513
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 513
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 514
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 514
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 515
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 516
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 516
ttcacctttg acacatatgc catgaat                                           27


<210> 517
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 517
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 518
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 518
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 519
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 519
Val Arg His Gly Asn Phe Gly Asn Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 520
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 520
gtcaggcacg gtaacttcgg gaacgcttac gtatcctggt ttgctcat                    48


<210> 521
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 521
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 522
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 522
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 523
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 523
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 524
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 524
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 525
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 525
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 526
ggcacagaca agcgcgctcc t                                                 21


<210> 527
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 527
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 528
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 528
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 529
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 529
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacgc tctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 530
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 530
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 531
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 531
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 532
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 532
ttcacctttg acacatatgc catgaat                                           27


<210> 533
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 533
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 534
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 534
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 535
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 535
Val Arg His Gly Asn Phe Gly Asn Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 536
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 536
gtcaggcacg gtaacttcgg gaacgcttac gtatcctggt ttgctcat                    48


<210> 537
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 537
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 538
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 538
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 539
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 539
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 540
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 540
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 541
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 541
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 542
ggcacagaca agcgcgctcc t                                                 21


<210> 543
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 543
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 544
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 544
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 545
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 545
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 546
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 546
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 547
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 547
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 548
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 548
ttcacctttg acacatatgc catgaat                                           27


<210> 549
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 549
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 550
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 550
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 551
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 551
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 552
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 552
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 553
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 553
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 554
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 554
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 555
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 555
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 556
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 556
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 557
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 558
ggcacagaca agcgcgctcc t                                                 21


<210> 559
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 559
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 560
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 560
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 561
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 561
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 562
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 562
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 563
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 563
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 564
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 564
ttcacctttg acacatatgc catgaat                                           27


<210> 565
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 565
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 566
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 566
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 567
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 567
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 568
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 568
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 569
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 569
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 570
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 570
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 571
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 571
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 572
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 572
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 573
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 573
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 574
ggcacagaca agcgcgctcc t                                                 21


<210> 575
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 575
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 576
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 576
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 577
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 577
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 578
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 578
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 579
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 579
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 580
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 580
ttcacctttg acacatatgc catgaat                                           27


<210> 581
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 581
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 582
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 582
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 583
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 583
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 584
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 584
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 585
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 585
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 586
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 586
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 587
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 587
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 588
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 588
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 589
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 589
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 590
ggcacagaca agcgcgctcc t                                                 21


<210> 591
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 591
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 592
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 592
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 593
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 593
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 594
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 594
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 595
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 595
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 596
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 596
ttcacctttg acacatatgc catgaat                                           27


<210> 597
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 597
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 598
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 598
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 599
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 599
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 600
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 600
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 601
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 601
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 602
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 602
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 603
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 603
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 604
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 604
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 605
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 605
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 606
ggcacagaca agcgcgctcc t                                                 21


<210> 607
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 607
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 608
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 608
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 609
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 609
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 610
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 610
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 611
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 611
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 612
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 612
ttcacctttg acacatatgc catgaat                                           27


<210> 613
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 613
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 614
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 614
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 615
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 615
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 616
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 616
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 617
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 617
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 618
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 618
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 619
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 619
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 620
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 620
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 621
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 621
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 622
ggcacagaca agcgcgctcc t                                                 21


<210> 623
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 623
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 624
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 624
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 625
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 625
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 626
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 626
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 627
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 627
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 628
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 628
ttcacctttg acacatatgc catgaat                                           27


<210> 629
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 629
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 630
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 630
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 631
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 631
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 632
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 632
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 633
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 633
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 634
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 634
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 635
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 635
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 636
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 636
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 637
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 637
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 638
ggcacagaca agcgcgctcc t                                                 21


<210> 639
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 639
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 640
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 640
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 641
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 641
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactactcat actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 642
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 642
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ser Tyr 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 643
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 643
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 644
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 644
ttcacctttg acacatatgc catgaat                                           27


<210> 645
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 645
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ser Tyr Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 646
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 646
aggattagat ccaagtataa caattacgct acatactact catactccgt gaaggat          57


<210> 647
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 647
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 648
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 648
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 649
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 649
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 650
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 650
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 651
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 651
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 652
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 652
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 653
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 653
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 654
ggcacagaca agcgcgctcc t                                                 21


<210> 655
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 655
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 656
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 656
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 657
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 657
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 658
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 658
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 659
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 659
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 660
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 660
ttcacctttg acacatatgc catgaat                                           27


<210> 661
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 661
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 662
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 662
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 663
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 663
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 664
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 664
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 665
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 665
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 666
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 666
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 667
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 667
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 668
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 668
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 669
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 669
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 670
ggcacagaca agcgcgctcc t                                                 21


<210> 671
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 671
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 672
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 672
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 673
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 673
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 674
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 674
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 675
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 675
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 676
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 676
ttcacctttg acacatatgc catgaat                                           27


<210> 677
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 677
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 678
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 678
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 679
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 679
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 680
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 680
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 681
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 681
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 682
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 682
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 683
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 683
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 684
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 684
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 685
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 685
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 686
ggcacagaca agcgcgctcc t                                                 21


<210> 687
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 687
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 688
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 688
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 689
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 689
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 690
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 690
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 691
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 691
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 692
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 692
ttcacctttg acacatatgc catgaat                                           27


<210> 693
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 693
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 694
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 694
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 695
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 695
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 696
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 696
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 697
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 697
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 698
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 698
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 699
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 699
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 700
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 700
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 701
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 701
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 702
ggcacagaca agcgcgctcc t                                                 21


<210> 703
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 703
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 704
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 704
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 705
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 705
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 706
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 706
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 707
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 707
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 708
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 708
ttcacctttg acacatatgc catgaat                                           27


<210> 709
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 709
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 710
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 710
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 711
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 711
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 712
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 712
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 713
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 713
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 714
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 714
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 715
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 715
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 716
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 716
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 717
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 717
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 718
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 718
ggcacagaca agcgcgctcc t                                                 21


<210> 719
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 719
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 720
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 720
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 721
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 721
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 722
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 722
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 723
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 723
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 724
ttcacctttg acacatatgc catgaat                                           27


<210> 725
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 725
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 726
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 726
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 727
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 727
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 728
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 728
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 729
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 729
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 730
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 730
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 731
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 731
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 732
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 732
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 733
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 733
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 734
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 734
ggcacagaca agcgcgctcc t                                                 21


<210> 735
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 735
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 736
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 736
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 737
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 737
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 738
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 738
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 739
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 739
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 740
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 740
ttcacctttg acacatatgc catgaat                                           27


<210> 741
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 741
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 742
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 742
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 743
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 743
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 744
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 744
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 745
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 745
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgtt tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 746
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 746
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 747
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 747
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 748
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 748
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 749
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 749
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 750
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 750
ggcacagaca agcgcgctcc t                                                 21


<210> 751
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 751
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 752
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 752
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 753
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 753
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 754
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 754
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 755
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 755
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 756
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 756
ttcacctttg acacatatgc catgaat                                           27


<210> 757
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 757
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 758
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 758
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 759
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 759
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 760
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 760
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 761
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 761
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 762
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 762
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 763
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 763
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 764
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 764
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 765
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 765
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 766
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 766
ggcacagaca agcgcgctcc t                                                 21


<210> 767
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 767
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 768
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 768
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 769
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 769
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 770
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 770
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 771
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 772
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 772
ttcacctttg acacatatgc catgaat                                           27


<210> 773
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 773
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 774
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 774
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 775
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 775
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 776
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 776
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 777
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 777
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 778
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 778
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 779
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 779
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 780
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 780
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 781
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 781
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 782
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 782
ggcacagaca agcgcgctcc t                                                 21


<210> 783
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 783
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 784
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 784
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 785
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 785
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 786
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 786
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 787
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 787
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 788
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 788
ttcacctttg acacatatgc catgaat                                           27


<210> 789
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 789
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 790
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 790
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 791
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 791
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 792
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 792
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 793
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 793
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 794
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 794
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 795
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 795
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 796
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 796
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 797
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 798
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 798
ggcacagaca agcgcgctcc t                                                 21


<210> 799
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 799
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 800
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 800
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 801
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 801
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 802
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 802
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 803
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 803
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 804
ttcacctttg acacatatgc catgaat                                           27


<210> 805
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 805
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 806
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 806
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 807
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 807
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 808
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 808
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 809
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 809
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 810
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 810
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 811
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 811
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 812
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 812
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 813
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 813
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 814
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 814
ggcacagaca agcgcgctcc t                                                 21


<210> 815
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 815
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 816
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 816
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 817
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 817
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 818
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 818
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 819
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 819
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 820
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 820
ttcacctttg acacatatgc catgaat                                           27


<210> 821
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 821
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 822
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 822
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 823
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 823
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 824
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 824
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 825
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 825
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 826
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 826
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 827
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 827
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 828
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 828
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 829
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 829
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 830
ggcacagaca agcgcgctcc t                                                 21


<210> 831
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 831
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 832
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 832
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 833
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 833
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 834
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 834
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 835
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 835
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 836
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 836
ttcacctttg acacatatgc catgaat                                           27


<210> 837
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 837
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 838
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 838
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 839
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 839
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 840
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 840
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 841
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 841
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 842
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 842
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 843
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 843
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 844
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 844
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 845
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 845
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 846
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 846
ggcacagaca agcgcgctcc t                                                 21


<210> 847
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 847
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 848
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 848
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 849
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 849
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 850
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 850
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 851
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 852
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 852
ttcacctttg acacatatgc catgaat                                           27


<210> 853
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 853
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 854
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 854
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 855
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 855
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 856
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 856
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 857
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 857
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 858
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 858
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 859
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 859
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 860
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 860
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 861
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 861
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 862
ggcacagaca agcgcgctcc t                                                 21


<210> 863
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 863
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 864
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 864
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 865
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 865
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 866
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 866
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 867
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 867
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 868
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 868
ttcacctttg acacatatgc catgaat                                           27


<210> 869
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 869
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 870
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 870
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 871
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 871
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 872
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 872
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 873
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 873
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 874
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 874
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 875
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 875
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 876
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 876
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 877
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 877
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 878
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 878
ggcacagaca agcgcgctcc t                                                 21


<210> 879
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 879
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 880
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 880
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 881
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 881
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 882
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 882
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 883
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 883
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 884
ttcacctttg acacatatgc catgaat                                           27


<210> 885
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 885
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 886
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 886
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 887
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 887
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 888
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 888
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 889
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 889
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 890
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 890
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 891
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 891
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 892
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 892
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 893
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 893
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 894
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 894
ggcacagaca agcgcgctcc t                                                 21


<210> 895
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 895
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 896
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 896
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 897
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 897
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 898
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 898
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 899
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 899
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 900
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 900
ttcacctttg acacatatgc catgaat                                           27


<210> 901
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 901
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 902
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 902
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 903
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 903
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 904
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 904
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 905
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 905
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 906
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 906
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 907
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 907
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 908
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 908
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 909
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 909
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 910
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 910
ggcacagaca agcgcgctcc t                                                 21


<210> 911
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 911
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 912
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 912
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 913
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 913
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 914
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 914
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 915
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 915
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 916
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 916
ttcacctttg acacatatgc catgaat                                           27


<210> 917
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 917
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 918
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 918
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 919
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 919
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 920
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 920
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 921
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 921
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 922
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 922
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 923
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 923
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 924
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 924
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 925
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 925
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 926
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 926
ggcacagaca agcgcgctcc t                                                 21


<210> 927
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 927
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 928
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 928
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 929
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 929
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 930
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 930
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 931
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 931
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 932
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 932
ttcacctttg acacatatgc catgaat                                           27


<210> 933
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 933
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 934
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 934
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 935
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 935
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 936
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 936
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 937
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 937
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 938
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 938
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 939
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 939
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 940
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 940
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 941
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 941
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 942
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 942
ggcacagaca agcgcgctcc t                                                 21


<210> 943
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 943
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 944
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 944
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 945
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 945
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 946
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 946
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 947
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 947
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 948
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 948
ttcacctttg acacatatgc catgaat                                           27


<210> 949
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 949
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 950
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 950
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 951
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 951
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 952
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 952
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 953
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 953
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatctct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 954
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 954
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Leu Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 955
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 955
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 956
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 956
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 957
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 957
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 958
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 958
ggcacagaca agcgcgctcc t                                                 21


<210> 959
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 959
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 960
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 960
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 961
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 961
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 962
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 962
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 963
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 963
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 964
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 964
ttcacctttg acacatatgc catgaat                                           27


<210> 965
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 965
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 966
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 966
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 967
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 967
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 968
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 968
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 969
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 969
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 970
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 970
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 971
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 971
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 972
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 972
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 973
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 973
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 974
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 974
ggcacagaca agcgcgctcc t                                                 21


<210> 975
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 975
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 976
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 976
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 977
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 977
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 978
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 978
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 979
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 979
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 980
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 980
ttcacctttg acacatatgc catgaat                                           27


<210> 981
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 981
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 982
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 982
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 983
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 983
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 984
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 984
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 985
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 985
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 986
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 986
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 987
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 987
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 988
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 988
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 989
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 989
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 990
ggcacagaca agcgcgctcc t                                                 21


<210> 991
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 991
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 992
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 992
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 993
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 993
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 994
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 994
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 995
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 995
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 996
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 996
ttcacctttg acacatatgc catgaat                                           27


<210> 997
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 997
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 998
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 998
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 999
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 999
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1000
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1000
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1001
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1001
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 1002
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1002
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1003
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1003
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1004
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1004
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1005
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1005
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1006
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1006
ggcacagaca agcgcgctcc t                                                 21


<210> 1007
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1007
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1008
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1008
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1009
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1009
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagt gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1010
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1010
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1011
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1011
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1012
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1012
ttcacctttg acacatatgc catgaat                                           27


<210> 1013
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1013
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1014
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1014
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1015
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1015
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1016
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1016
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1017
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1017
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 1018
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1018
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1019
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1019
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1020
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1020
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1021
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1021
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1022
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1022
ggcacagaca agcgcgctcc t                                                 21


<210> 1023
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1023
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1024
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1024
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1025
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1025
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggggat gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1026
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1026
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gly Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1027
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1027
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1028
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1028
ttcacctttg acacatatgc catgaat                                           27


<210> 1029
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1029
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1030
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1030
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1031
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1031
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1032
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1032
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1033
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1033
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 1034
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1034
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1035
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1035
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1036
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1036
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1037
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1037
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1038
ggcacagaca agcgcgctcc t                                                 21


<210> 1039
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1039
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1040
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1040
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1041
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1041
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggggat gtctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1042
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1042
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gly Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1043
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1043
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1044
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1044
ttcacctttg acacatatgc catgaat                                           27


<210> 1045
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1045
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1046
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1046
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1047
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1047
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1048
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1048
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1049
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1049
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cttgatctct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggctgtggga ccaagctgac cgtccta                                          327


<210> 1050
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1050
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Leu Asp Leu Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1051
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1051
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1052
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1052
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1053
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1053
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1054
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1054
ggcacagaca agcgcgctcc t                                                 21


<210> 1055
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1055
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1056
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1056
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1057
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1057
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tccagggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1058
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1058
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1059
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1059
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1060
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1060
ttcacctttg acacatatgc catgaac                                           27


<210> 1061
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1061
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1062
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1062
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1063
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1063
Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1064
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1064
gtcaggcacg gtaacttcca gggtggttac gtatcctggt ttgctcat                    48


<210> 1065
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1065
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1066
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1066
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1067
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1067
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1068
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1068
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1069
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1069
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1070
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1070
ggcacagaca agcgcgctcc t                                                 21


<210> 1071
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1071
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1072
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1072
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1073
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1073
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggggg ttacgtatcc tggtttgctt ggtggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1074
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1074
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Trp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1075
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1075
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1076
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1076
ttcacctttg acacatatgc catgaac                                           27


<210> 1077
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1077
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1078
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1078
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1079
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1079
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe Ala Trp 
1               5                   10                  15      


<210> 1080
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1080
gtcaggcacg gtaacttcgg ggggggttac gtatcctggt ttgcttgg                    48


<210> 1081
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1081
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1082
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1082
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1083
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1083
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1084
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1084
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1085
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1085
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1086
ggcacagaca agcgcgctcc t                                                 21


<210> 1087
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1087
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1088
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1088
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1089
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1089
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgcgaact tcggggcggg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1090
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1090
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ala Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1091
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1091
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1092
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1092
ttcacctttg acacatatgc catgaac                                           27


<210> 1093
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1093
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1094
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1094
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1095
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1095
Val Arg His Ala Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1096
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1096
gtcaggcacg cgaacttcgg ggcgggttac gtatcctggt ttgctcat                    48


<210> 1097
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1097
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1098
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1098
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1099
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1099
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1100
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1100
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1101
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1102
ggcacagaca agcgcgctcc t                                                 21


<210> 1103
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1103
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1104
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1104
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1105
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1105
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1106
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1106
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1107
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1108
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1108
ttcacctttg acacatatgc catgaac                                           27


<210> 1109
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1109
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1110
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1110
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1111
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1111
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1112
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1112
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 1113
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1113
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1114
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1114
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1115
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1115
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1116
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1116
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1117
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1117
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1118
ggcacagaca agcgcgctcc t                                                 21


<210> 1119
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1119
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1120
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1120
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1121
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1121
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1122
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1122
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1123
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1123
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1124
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1124
ttcacctttg acacatatgc catgaac                                           27


<210> 1125
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1125
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1126
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1126
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1127
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1127
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1128
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1128
gtcaggcacg ataacttcgg ggctggttac gtatcctggt ttgctcat                    48


<210> 1129
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1129
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1130
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1130
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1131
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1131
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1132
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1132
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1133
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1133
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1134
ggcacagaca agcgcgctcc t                                                 21


<210> 1135
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1135
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1136
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1136
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1137
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1137
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggttgg ttacgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1138
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1138
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1139
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1139
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1140
ttcacctttg acacatatgc catgaac                                           27


<210> 1141
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1141
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1142
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1142
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1143
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1143
Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 1144
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1144
gtcaggcacg gtaacttcgg ggttggttac gtatcctggt ttgcttct                    48


<210> 1145
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1145
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1146
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1146
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1147
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1147
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1148
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1148
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1149
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1149
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1150
ggcacagaca agcgcgctcc t                                                 21


<210> 1151
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1151
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1152
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1152
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1153
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1153
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1154
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1154
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1155
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1155
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1156
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1156
ttcacctttg acacatatgc catgaac                                           27


<210> 1157
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1157
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1158
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1158
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1159
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1159
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1160
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1160
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 1161
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1161
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1162
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1162
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1163
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1163
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1164
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1164
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1165
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1165
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1166
ggcacagaca agcgcgctcc t                                                 21


<210> 1167
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1167
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1168
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1168
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1169
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1169
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1170
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1170
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1171
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1172
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1172
ttcacctttg acacatatgc catgaac                                           27


<210> 1173
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1173
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1174
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1174
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1175
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1175
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1176
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1176
gtcaggcacg ataacttcgg ggctggttac gtatcctggt ttgctcat                    48


<210> 1177
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1177
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1178
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1178
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1179
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1179
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1180
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1180
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1181
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1181
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1182
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1182
ggcacagaca agcgcgctcc t                                                 21


<210> 1183
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1183
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1184
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1184
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1185
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1185
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggttgg ttacgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1186
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1186
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1187
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1188
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1188
ttcacctttg acacatatgc catgaac                                           27


<210> 1189
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1189
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1190
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1190
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1191
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1191
Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 1192
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1192
gtcaggcacg gtaacttcgg ggttggttac gtatcctggt ttgcttct                    48


<210> 1193
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1193
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1194
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1194
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1195
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1195
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1196
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1196
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1197
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1197
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1198
ggcacagaca agcgcgctcc t                                                 21


<210> 1199
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1199
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1200
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1200
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1201
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1201
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggtgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1202
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1202
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1203
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1203
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1204
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1204
ttcacctttg acacatatgc catgaac                                           27


<210> 1205
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1205
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1206
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1206
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1207
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1207
Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1208
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1208
gtcaggcacg gtaacttcgg gggtgcttac gtatcctggt ttgctcat                    48


<210> 1209
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1209
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1210
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1210
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1211
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1211
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1212
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1212
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1213
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1214
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1214
ggcacagaca agcgcgctcc t                                                 21


<210> 1215
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1215
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1216
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1216
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1217
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1217
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggggg ttacgtatcc tggtttgggc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1218
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1218
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Gly His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1219
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1220
ttcacctttg acgcttatgc catgaac                                           27


<210> 1221
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1221
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1222
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1222
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1223
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1223
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe Gly His 
1               5                   10                  15      


<210> 1224
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1224
gtcaggcacg gtaacttcgg ggggggttac gtatcctggt ttgggcat                    48


<210> 1225
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1225
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1226
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1226
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1227
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1227
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1228
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1228
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1229
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1230
ggcacagaca agcgcgctcc t                                                 21


<210> 1231
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1231
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1232
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1232
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1233
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1233
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacta tgctgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1234
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1234
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1235
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1236
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1236
ttcacctttg acgcttatgc catgaac                                           27


<210> 1237
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1237
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1238
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1238
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1239
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1239
Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1240
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1240
gtcaggcacg gtaacttcgg gaactatgct gtatcctggt ttgctcat                    48


<210> 1241
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1241
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1242
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1242
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1243
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1243
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1244
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1244
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1245
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1246
ggcacagaca agcgcgctcc t                                                 21


<210> 1247
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1247
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1248
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1248
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1249
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1249
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tccagggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1250
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1250
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1251
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1252
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1252
ttcacctttg acacatatgc catgaac                                           27


<210> 1253
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1253
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1254
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1254
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1255
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1255
Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1256
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1256
gtcaggcacg gtaacttcca gggtggttac gtatcctggt ttgctcat                    48


<210> 1257
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1257
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1258
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1258
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1259
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1259
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1260
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1260
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1261
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1262
ggcacagaca agcgcgctcc t                                                 21


<210> 1263
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1263
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1264
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1264
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1265
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1265
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgcgaact tcggggcggg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1266
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1266
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ala Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1267
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1268
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1268
ttcacctttg acacatatgc catgaac                                           27


<210> 1269
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1269
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1270
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1270
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1271
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1271
Val Arg His Ala Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1272
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1272
gtcaggcacg cgaacttcgg ggcgggttac gtatcctggt ttgctcat                    48


<210> 1273
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1273
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1274
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1274
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1275
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1275
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1276
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1276
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1277
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1277
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1278
ggcacagaca agcgcgctcc t                                                 21


<210> 1279
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1279
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1280
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1280
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1281
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1281
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1282
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1282
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1283
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1283
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1284
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1284
ttcacctttg acacatatgc catgaac                                           27


<210> 1285
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1285
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1286
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1286
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1287
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1287
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1288
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1288
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 1289
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1289
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1290
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1290
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1291
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1291
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1292
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1292
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1293
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1294
ggcacagaca agcgcgctcc t                                                 21


<210> 1295
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1295
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1296
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1296
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1297
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1297
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1298
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1298
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1299
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1300
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1300
ttcacctttg acacatatgc catgaac                                           27


<210> 1301
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1301
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1302
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1302
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1303
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1303
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1304
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1304
gtcaggcacg ataacttcgg ggctggttac gtatcctggt ttgctcat                    48


<210> 1305
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1305
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1306
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1306
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1307
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1307
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1308
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1308
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1309
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1310
ggcacagaca agcgcgctcc t                                                 21


<210> 1311
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1311
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1312
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1312
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1313
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1313
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggtgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1314
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1314
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1315
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1315
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1316
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1316
ttcacctttg acacatatgc catgaac                                           27


<210> 1317
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1317
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1318
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1318
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1319
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1319
Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1320
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1320
gtcaggcacg gtaacttcgg gggtgcttac gtatcctggt ttgctcat                    48


<210> 1321
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1321
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1322
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1322
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1323
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1323
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1324
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1324
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1325
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1326
ggcacagaca agcgcgctcc t                                                 21


<210> 1327
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1327
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1328
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1328
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1329
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1329
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1330
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1330
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1331
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1332
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1332
ttcacctttg acacatatgc catgaac                                           27


<210> 1333
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1333
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1334
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1334
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1335
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1335
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1336
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1336
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 1337
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1337
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1338
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1338
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1339
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1339
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1340
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1340
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1341
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1341
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1342
ggcacagaca agcgcgctcc t                                                 21


<210> 1343
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1343
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1344
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1344
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1345
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1345
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatca tggtttgctc attggggcca aggaaccctg      360

gtcaccgtat cctca                                                       375


<210> 1346
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1346
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1347
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1347
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1348
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1348
ttcacctttg acacatatgc catgaac                                           27


<210> 1349
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1349
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1350
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1350
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1351
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1351
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1352
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1352
gtcaggcacg ataacttcgg ggctggttac gtatcatggt ttgctcat                    48


<210> 1353
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1353
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1354
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1354
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1355
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1355
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1356
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1356
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1357
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1357
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1358
ggcacagaca agcgcgctcc t                                                 21


<210> 1359
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1359
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1360
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1360
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1361
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1361
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggttgg ttacgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1362
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1362
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1363
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1364
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1364
ttcacctttg acacatatgc catgaac                                           27


<210> 1365
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1365
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1366
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1366
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1367
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1367
Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 1368
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1368
gtcaggcacg gtaacttcgg ggttggttac gtatcctggt ttgcttct                    48


<210> 1369
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1369
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1370
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1370
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1371
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1371
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1372
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1372
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1373
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1373
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1374
ggcacagaca agcgcgctcc t                                                 21


<210> 1375
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1375
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1376
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1376
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1377
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1377
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggtgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1378
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1378
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1379
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1379
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1380
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1380
ttcacctttg acacatatgc catgaac                                           27


<210> 1381
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1381
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1382
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1382
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1383
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1383
Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1384
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1384
gtcaggcacg gtaacttcgg gggtgcttac gtatcctggt ttgctcat                    48


<210> 1385
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1385
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1386
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1386
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1387
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1387
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1388
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1388
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1389
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1390
ggcacagaca agcgcgctcc t                                                 21


<210> 1391
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1391
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1392
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1392
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1393
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1393
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggggg ttacgtatcc tggtttgggc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1394
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1394
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Gly His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1395
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1396
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1396
ttcacctttg acgcttatgc catgaac                                           27


<210> 1397
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1397
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1398
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1398
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1399
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1399
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe Gly His 
1               5                   10                  15      


<210> 1400
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1400
gtcaggcacg gtaacttcgg ggggggttac gtatcctggt ttgggcat                    48


<210> 1401
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1401
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1402
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1402
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1403
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1403
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1404
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1404
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1405
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1406
ggcacagaca agcgcgctcc t                                                 21


<210> 1407
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1407
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1408
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1408
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1409
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1409
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaacg tggggggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1410
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1410
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Val Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1411
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1412
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1412
ttcacctttg acgcttatgc catgaac                                           27


<210> 1413
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1413
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1414
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1414
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1415
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1415
Val Arg His Gly Asn Val Gly Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1416
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1416
gtcaggcacg gtaacgtggg gggtggttac gtatcctggt ttgctcat                    48


<210> 1417
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1417
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1418
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1418
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1419
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1419
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1420
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1420
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1421
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1421
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1422
ggcacagaca agcgcgctcc t                                                 21


<210> 1423
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1423
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1424
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1424
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1425
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1425
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacta tgctgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1426
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1426
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1427
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1427
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1428
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1428
ttcacctttg acgcttatgc catgaac                                           27


<210> 1429
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1429
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1430
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1430
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1431
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1431
Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1432
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1432
gtcaggcacg gtaacttcgg gaactatgct gtatcctggt ttgctcat                    48


<210> 1433
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1433
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1434
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1434
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1435
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1435
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1436
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1436
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1437
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1437
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1438
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1438
ggcacagaca agcgcgctcc t                                                 21


<210> 1439
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1439
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1440
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1440
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1441
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1441
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tccagggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1442
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1442
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1443
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1444
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1444
ttcacctttg acacatatgc catgaac                                           27


<210> 1445
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1445
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1446
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1446
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1447
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1447
Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1448
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1448
gtcaggcacg gtaacttcca gggtggttac gtatcctggt ttgctcat                    48


<210> 1449
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1449
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1450
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1450
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1451
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1451
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1452
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1452
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1453
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1453
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1454
ggcacagaca agcgcgctcc t                                                 21


<210> 1455
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1455
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1456
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1456
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1457
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1457
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggggg ttacgtatcc tggtttgctt ggtggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1458
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1458
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Trp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1459
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1460
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1460
ttcacctttg acacatatgc catgaac                                           27


<210> 1461
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1461
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1462
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1462
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1463
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1463
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe Ala Trp 
1               5                   10                  15      


<210> 1464
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1464
gtcaggcacg gtaacttcgg ggggggttac gtatcctggt ttgcttgg                    48


<210> 1465
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1465
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1466
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1466
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1467
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1467
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1468
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1468
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1469
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1469
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1470
ggcacagaca agcgcgctcc t                                                 21


<210> 1471
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1471
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1472
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1472
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1473
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1473
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgcgaact tcggggcggg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1474
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1474
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ala Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1475
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1476
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1476
ttcacctttg acacatatgc catgaac                                           27


<210> 1477
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1477
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1478
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1478
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1479
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1479
Val Arg His Ala Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1480
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1480
gtcaggcacg cgaacttcgg ggcgggttac gtatcctggt ttgctcat                    48


<210> 1481
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1481
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1482
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1482
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1483
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1483
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1484
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1484
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1485
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1485
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1486
ggcacagaca agcgcgctcc t                                                 21


<210> 1487
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1487
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1488
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1488
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1489
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1489
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1490
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1490
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1491
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1492
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1492
ttcacctttg acacatatgc catgaac                                           27


<210> 1493
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1493
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1494
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1494
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1495
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1495
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1496
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1496
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 1497
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1497
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1498
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1498
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1499
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1499
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1500
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1500
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1501
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1501
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1502
ggcacagaca agcgcgctcc t                                                 21


<210> 1503
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1503
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1504
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1504
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1505
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1505
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1506
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1506
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1507
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1507
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1508
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1508
ttcacctttg acacatatgc catgaac                                           27


<210> 1509
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1509
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1510
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1510
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1511
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1511
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1512
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1512
gtcaggcacg ataacttcgg ggctggttac gtatcctggt ttgctcat                    48


<210> 1513
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1513
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1514
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1514
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1515
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1515
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1516
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1516
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1517
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1518
ggcacagaca agcgcgctcc t                                                 21


<210> 1519
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1519
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1520
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1520
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1521
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1521
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggttgg ttacgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1522
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1522
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1523
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1524
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1524
ttcacctttg acacatatgc catgaac                                           27


<210> 1525
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1525
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1526
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1526
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1527
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1527
Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 1528
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1528
gtcaggcacg gtaacttcgg ggttggttac gtatcctggt ttgcttct                    48


<210> 1529
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1529
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1530
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1530
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1531
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1531
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1532
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1532
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1533
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1533
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1534
ggcacagaca agcgcgctcc t                                                 21


<210> 1535
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1535
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1536
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1536
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1537
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1537
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggtgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1538
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1538
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1539
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1540
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1540
ttcacctttg acacatatgc catgaac                                           27


<210> 1541
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1541
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1542
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1542
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1543
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1543
Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1544
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1544
gtcaggcacg gtaacttcgg gggtgcttac gtatcctggt ttgctcat                    48


<210> 1545
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1545
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1546
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1546
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1547
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1547
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1548
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1548
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1549
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1549
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1550
ggcacagaca agcgcgctcc t                                                 21


<210> 1551
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1551
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1552
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1552
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1553
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1553
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggaagg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1554
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1554
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1555
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1555
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1556
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1556
ttcacctttg acacatatgc catgaac                                           27


<210> 1557
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1557
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1558
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1558
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1559
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1559
Val Arg His Gly Asn Phe Gly Glu Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1560
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1560
gtcaggcacg gtaacttcgg ggaaggttac gtatcctggt ttgctcat                    48


<210> 1561
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1561
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1562
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1562
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1563
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1563
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1564
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1564
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1565
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1565
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1566
ggcacagaca agcgcgctcc t                                                 21


<210> 1567
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1567
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1568
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1568
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1569
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1569
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1570
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1570
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1571
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1571
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1572
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1572
ttcacctttg acacatatgc catgaac                                           27


<210> 1573
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1573
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1574
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1574
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1575
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1575
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1576
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1576
gtcaggcacg ataacttcgg ggctggttac gtatcctggt ttgctcat                    48


<210> 1577
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1577
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1578
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1578
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1579
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1579
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1580
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1580
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1581
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1581
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1582
ggcacagaca agcgcgctcc t                                                 21


<210> 1583
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1583
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1584
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1584
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1585
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1585
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggttgg ttacgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1586
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1586
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1587
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1587
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1588
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1588
ttcacctttg acacatatgc catgaac                                           27


<210> 1589
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1589
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1590
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1590
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1591
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1591
Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 1592
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1592
gtcaggcacg gtaacttcgg ggttggttac gtatcctggt ttgcttct                    48


<210> 1593
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1593
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1594
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1594
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1595
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1595
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1596
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1596
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1597
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1597
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1598
ggcacagaca agcgcgctcc t                                                 21


<210> 1599
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1599
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1600
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1600
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1601
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1601
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggtgc ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1602
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1602
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1603
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1603
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1604
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1604
ttcacctttg acacatatgc catgaac                                           27


<210> 1605
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1605
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1606
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1606
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1607
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1607
Val Arg His Gly Asn Phe Gly Gly Ala Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1608
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1608
gtcaggcacg gtaacttcgg gggtgcttac gtatcctggt ttgctcat                    48


<210> 1609
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1609
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1610
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1610
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1611
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1611
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1612
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1612
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1613
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1613
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1614
ggcacagaca agcgcgctcc t                                                 21


<210> 1615
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1615
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1616
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1616
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1617
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1617
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggggg ttacgtatcc tggtttgggc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1618
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1618
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Gly His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1619
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1619
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1620
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1620
ttcacctttg acgcttatgc catgaac                                           27


<210> 1621
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1621
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1622
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1622
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1623
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1623
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe Gly His 
1               5                   10                  15      


<210> 1624
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1624
gtcaggcacg gtaacttcgg ggggggttac gtatcctggt ttgggcat                    48


<210> 1625
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1625
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1626
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1626
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1627
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1627
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1628
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1628
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1629
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1629
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1630
ggcacagaca agcgcgctcc t                                                 21


<210> 1631
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1631
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1632
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1632
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1633
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1633
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaacg tggggggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1634
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1634
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Val Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1635
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1635
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1636
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1636
ttcacctttg acgcttatgc catgaac                                           27


<210> 1637
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1637
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1638
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1638
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1639
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1639
Val Arg His Gly Asn Val Gly Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1640
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1640
gtcaggcacg gtaacgtggg gggtggttac gtatcctggt ttgctcat                    48


<210> 1641
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1641
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1642
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1642
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1643
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1643
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1644
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1644
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1645
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1645
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1646
ggcacagaca agcgcgctcc t                                                 21


<210> 1647
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1647
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1648
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1648
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1649
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1649
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gcttatgcca tgaactgggt gcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacga ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacta tgctgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1650
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1650
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1651
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1651
Phe Thr Phe Asp Ala Tyr Ala Met Asn 
1               5                   


<210> 1652
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1652
ttcacctttg acgcttatgc catgaac                                           27


<210> 1653
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1653
Arg Ile Arg Ser Lys Tyr Asn Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1654
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1654
aggattagat ccaagtataa cgattacgct acatactacg cagactccgt gaaggat          57


<210> 1655
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1655
Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1656
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1656
gtcaggcacg gtaacttcgg gaactatgct gtatcctggt ttgctcat                    48


<210> 1657
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1657
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtgatct gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1658
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1658
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1659
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1659
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1660
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1660
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1661
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1661
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1662
ggcacagaca agcgcgctcc t                                                 21


<210> 1663
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1663
Ala Leu Trp Tyr Ser Asp Leu Trp Val 
1               5                   


<210> 1664
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1664
gcgctgtggt acagtgatct gtgggtg                                           27


<210> 1665
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1665
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1666
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1666
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1667
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1667
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1668
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1668
ttcacctttg acacatatgc catgaat                                           27


<210> 1669
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1669
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1670
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1670
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1671
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1671
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1672
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1672
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1673
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1673
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1674
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1674
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1675
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1675
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1676
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1676
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1677
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1677
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1678
ggcacagaca agcgcgctcc t                                                 21


<210> 1679
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1679
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1680
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1680
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1681
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1681
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1682
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1682
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1683
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1683
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1684
ttcacctttg acacatatgc catgaat                                           27


<210> 1685
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1685
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1686
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1686
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1687
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1687
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1688
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1688
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1689
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1689
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1690
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1690
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1691
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1691
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1692
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1692
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1693
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1693
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1694
ggcacagaca agcgcgctcc t                                                 21


<210> 1695
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1695
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1696
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1696
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1697
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1697
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1698
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1698
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1699
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1699
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1700
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1700
ttcacctttg acacatatgc catgaat                                           27


<210> 1701
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1701
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1702
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1702
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1703
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1703
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1704
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1704
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1705
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1705
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1706
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1706
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1707
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1707
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1708
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1708
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1709
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1709
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1710
ggcacagaca agcgcgctcc t                                                 21


<210> 1711
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1711
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1712
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1712
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 1713
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1713
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1714
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1714
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1715
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1715
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1716
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1716
ttcacctttg acacatatgc catgaat                                           27


<210> 1717
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1717
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1718
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1718
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1719
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1719
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1720
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1720
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1721
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1721
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1722
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1722
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1723
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1723
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1724
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1724
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1725
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1725
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1726
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1726
ggcacagaca agcgcgctcc t                                                 21


<210> 1727
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1727
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1728
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1728
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1729
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1729
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1730
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1730
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1731
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1731
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1732
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1732
ttcacctttg acacatatgc catgaat                                           27


<210> 1733
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1733
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1734
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1734
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1735
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1735
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1736
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1736
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1737
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1737
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1738
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1738
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1739
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1739
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1740
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1740
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1741
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1741
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1742
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1742
ggcacagaca agcgcgctcc t                                                 21


<210> 1743
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1743
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1744
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1744
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1745
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1745
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1746
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1746
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1747
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1747
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1748
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1748
ttcacctttg acacatatgc catgaat                                           27


<210> 1749
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1749
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1750
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1750
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1751
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1751
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1752
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1752
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1753
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1753
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1754
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1754
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1755
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1755
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1756
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1756
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1757
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1757
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1758
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1758
ggcacagaca agcgcgctcc t                                                 21


<210> 1759
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1759
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1760
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1760
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1761
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1761
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1762
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1762
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1763
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1763
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1764
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1764
ttcacctttg acacatatgc catgaat                                           27


<210> 1765
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1765
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1766
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1766
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1767
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1767
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1768
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1768
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1769
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1769
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1770
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1770
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1771
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1771
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1772
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1772
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1773
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1773
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1774
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1774
ggcacagaca agcgcgctcc t                                                 21


<210> 1775
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1775
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 1776
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1776
gcgctgtggt acaataacct ttgggtg                                           27


<210> 1777
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1777
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1778
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1778
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1779
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1779
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1780
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1780
ttcacctttg acacatatgc catgaat                                           27


<210> 1781
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1781
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1782
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1782
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1783
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1783
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1784
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1784
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1785
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1785
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1786
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1786
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1787
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1787
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1788
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1788
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1789
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1789
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1790
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1790
ggcacagaca agcgcgctcc t                                                 21


<210> 1791
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1791
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1792
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1792
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 1793
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1793
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1794
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1794
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1795
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1795
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1796
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1796
ttcacctttg acacatatgc catgaat                                           27


<210> 1797
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1797
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1798
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1798
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1799
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1799
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1800
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1800
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1801
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1801
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1802
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1802
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1803
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1803
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1804
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1804
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1805
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1805
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1806
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1806
ggcacagaca agcgcgctcc t                                                 21


<210> 1807
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1807
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1808
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1808
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1809
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1809
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1810
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1810
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1811
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1811
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1812
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1812
ttcacctttg acacatatgc catgaat                                           27


<210> 1813
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1813
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1814
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1814
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1815
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1815
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1816
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1816
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1817
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1817
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1818
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1818
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1819
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1819
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1820
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1820
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1821
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1821
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1822
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1822
ggcacagaca agcgcgctcc t                                                 21


<210> 1823
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1823
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 1824
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1824
gcgctgtggt acaataacct ttgggtg                                           27


<210> 1825
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1825
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1826
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1826
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1827
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1827
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1828
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1828
ttcacctttg acacatatgc catgaat                                           27


<210> 1829
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1829
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 1830
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1830
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 1831
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1831
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1832
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1832
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 1833
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1833
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1834
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1834
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1835
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1835
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1836
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1836
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1837
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1837
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1838
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1838
ggcacagaca agcgcgctcc t                                                 21


<210> 1839
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1839
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1840
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1840
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 1841
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1841
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1842
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1842
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1843
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1843
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1844
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1844
ttcacctttg acacatatgc catgaat                                           27


<210> 1845
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1845
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1846
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1846
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1847
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1847
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1848
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1848
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1849
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1849
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1850
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1850
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1851
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1851
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1852
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1852
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1853
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1853
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1854
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1854
ggcacagaca agcgcgctcc t                                                 21


<210> 1855
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1855
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1856
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1856
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1857
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1857
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1858
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1858
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1859
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1859
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1860
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1860
ttcacctttg acacatatgc catgaat                                           27


<210> 1861
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1861
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1862
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1862
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1863
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1863
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1864
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1864
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1865
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1865
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1866
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1866
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1867
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1867
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1868
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1868
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1869
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1869
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1870
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1870
ggcacagaca agcgcgctcc t                                                 21


<210> 1871
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1871
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1872
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1872
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1873
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1873
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1874
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1874
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1875
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1875
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1876
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1876
ttcacctttg acacatatgc catgaat                                           27


<210> 1877
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1877
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1878
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1878
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1879
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1879
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1880
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1880
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1881
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1881
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1882
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1882
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1883
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1883
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1884
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1884
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1885
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1885
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1886
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1886
ggcacagaca agcgcgctcc t                                                 21


<210> 1887
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1887
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1888
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1888
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 1889
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1889
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1890
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1890
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1891
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1891
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1892
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1892
ttcacctttg acacatatgc catgaat                                           27


<210> 1893
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1893
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1894
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1894
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1895
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1895
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1896
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1896
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1897
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1897
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1898
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1898
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1899
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1899
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1900
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1900
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1901
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1901
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1902
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1902
ggcacagaca agcgcgctcc t                                                 21


<210> 1903
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1903
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1904
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1904
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1905
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1905
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1906
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1906
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1907
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1907
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1908
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1908
ttcacctttg acacatatgc catgaat                                           27


<210> 1909
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1909
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1910
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1910
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1911
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1911
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1912
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1912
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1913
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1913
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1914
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1914
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1915
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1915
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1916
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1916
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1917
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1917
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1918
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1918
ggcacagaca agcgcgctcc t                                                 21


<210> 1919
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1919
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1920
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1920
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1921
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1921
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1922
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1922
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1923
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1923
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1924
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1924
ttcacctttg acacatatgc catgaat                                           27


<210> 1925
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1925
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1926
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1926
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1927
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1927
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1928
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1928
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1929
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1929
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1930
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1930
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1931
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1931
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1932
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1932
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1933
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1933
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1934
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1934
ggcacagaca agcgcgctcc t                                                 21


<210> 1935
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1935
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1936
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1936
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 1937
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1937
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1938
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1938
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1939
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1939
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1940
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1940
ttcacctttg acacatatgc catgaat                                           27


<210> 1941
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1941
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1942
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1942
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1943
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1943
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1944
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1944
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1945
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1945
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1946
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1946
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1947
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1947
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1948
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1948
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1949
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1949
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1950
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1950
ggcacagaca agcgcgctcc t                                                 21


<210> 1951
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1951
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 1952
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1952
gcgctgtggt acaataacct ttgggtg                                           27


<210> 1953
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1953
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1954
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1954
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1955
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1955
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1956
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1956
ttcacctttg acacatatgc catgaat                                           27


<210> 1957
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1957
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1958
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1958
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1959
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1959
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1960
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1960
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1961
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1961
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1962
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1962
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1963
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1963
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1964
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1964
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1965
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1965
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1966
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1966
ggcacagaca agcgcgctcc t                                                 21


<210> 1967
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1967
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 1968
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1968
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 1969
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1969
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1970
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1970
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1971
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1971
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1972
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1972
ttcacctttg acacatatgc catgaat                                           27


<210> 1973
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1973
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1974
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1974
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1975
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1975
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1976
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1976
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1977
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1977
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1978
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1978
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1979
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1979
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1980
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1980
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1981
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1981
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1982
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1982
ggcacagaca agcgcgctcc t                                                 21


<210> 1983
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1983
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 1984
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 1984
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 1985
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 1985
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1986
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 1986
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1987
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 1987
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 1988
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 1988
ttcacctttg acacatatgc catgaat                                           27


<210> 1989
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 1989
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1990
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 1990
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 1991
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 1991
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 1992
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 1992
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 1993
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 1993
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 1994
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 1994
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1995
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 1995
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 1996
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 1996
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 1997
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 1997
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 1998
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 1998
ggcacagaca agcgcgctcc t                                                 21


<210> 1999
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 1999
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2000
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2000
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2001
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2001
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2002
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2002
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2003
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2003
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2004
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2004
ttcacctttg acacatatgc catgaat                                           27


<210> 2005
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2005
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2006
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2006
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2007
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2007
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2008
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2008
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2009
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2009
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2010
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2010
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2011
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2011
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2012
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2012
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2013
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2013
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2014
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2014
ggcacagaca agcgcgctcc t                                                 21


<210> 2015
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2015
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2016
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2016
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2017
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2017
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2018
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2018
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2019
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2019
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2020
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2020
ttcacctttg acacatatgc catgaat                                           27


<210> 2021
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2021
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2022
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2022
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2023
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2023
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2024
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2024
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2025
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2025
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2026
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2026
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2027
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2027
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2028
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2028
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2029
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2029
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2030
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2030
ggcacagaca agcgcgctcc t                                                 21


<210> 2031
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2031
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2032
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2032
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2033
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2033
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2034
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2034
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2035
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2035
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2036
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2036
ttcacctttg acacatatgc catgaat                                           27


<210> 2037
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2037
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2038
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2038
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2039
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2039
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2040
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2040
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2041
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2041
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2042
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2042
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2043
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2043
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2044
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2044
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2045
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2045
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2046
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2046
ggcacagaca agcgcgctcc t                                                 21


<210> 2047
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2047
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2048
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2048
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2049
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2049
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2050
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2050
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2051
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2051
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2052
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2052
ttcacctttg acacatatgc catgaat                                           27


<210> 2053
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2053
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2054
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2054
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2055
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2055
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2056
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2056
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2057
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2057
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2058
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2058
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2059
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2059
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2060
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2060
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2061
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2061
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2062
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2062
ggcacagaca agcgcgctcc t                                                 21


<210> 2063
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2063
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2064
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2064
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2065
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2065
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2066
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2066
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2067
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2067
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2068
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2068
ttcacctttg acacatatgc catgaat                                           27


<210> 2069
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2069
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2070
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2070
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2071
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2071
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2072
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2072
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2073
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2073
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2074
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2074
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2075
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2075
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2076
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2076
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2077
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2077
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2078
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2078
ggcacagaca agcgcgctcc t                                                 21


<210> 2079
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2079
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2080
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2080
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2081
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2081
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2082
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2082
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2083
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2083
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2084
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2084
ttcacctttg acacatatgc catgaat                                           27


<210> 2085
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2085
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2086
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2086
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2087
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2087
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2088
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2088
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2089
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2089
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2090
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2090
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2091
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2091
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2092
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2092
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2093
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2093
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2094
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2094
ggcacagaca agcgcgctcc t                                                 21


<210> 2095
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2095
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2096
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2096
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2097
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2097
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2098
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2098
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2099
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2099
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2100
ttcacctttg acacatatgc catgaat                                           27


<210> 2101
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2101
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2102
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2102
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2103
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2103
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2104
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2104
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2105
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2105
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2106
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2106
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2107
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2107
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2108
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2108
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2109
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2110
ggcacagaca agcgcgctcc t                                                 21


<210> 2111
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2111
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2112
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2112
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2113
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2113
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2114
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2114
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2115
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2116
ttcacctttg acacatatgc catgaat                                           27


<210> 2117
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2117
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2118
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2118
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2119
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2119
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2120
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2120
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2121
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2121
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2122
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2122
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2123
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2123
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2124
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2124
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2125
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2126
ggcacagaca agcgcgctcc t                                                 21


<210> 2127
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2127
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2128
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2128
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2129
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2129
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2130
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2130
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2131
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2132
ttcacctttg acacatatgc catgaat                                           27


<210> 2133
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2133
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2134
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2134
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2135
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2135
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2136
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2136
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2137
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2137
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2138
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2138
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2139
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2139
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2140
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2140
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2141
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2142
ggcacagaca agcgcgctcc t                                                 21


<210> 2143
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2143
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2144
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2144
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2145
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2145
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2146
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2146
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2147
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2148
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2148
ttcacctttg acacatatgc catgaat                                           27


<210> 2149
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2149
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2150
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2150
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2151
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2151
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2152
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2152
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2153
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2153
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2154
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2154
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2155
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2155
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2156
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2156
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2157
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2158
ggcacagaca agcgcgctcc t                                                 21


<210> 2159
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2159
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2160
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2160
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2161
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2161
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2162
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2162
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2163
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2164
ttcacctttg acacatatgc catgaat                                           27


<210> 2165
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2165
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2166
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2166
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2167
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2167
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2168
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2168
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2169
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2169
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2170
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2170
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2171
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2171
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2172
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2172
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2173
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2174
ggcacagaca agcgcgctcc t                                                 21


<210> 2175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2175
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2176
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2176
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2177
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2177
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2178
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2178
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2179
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2180
ttcacctttg acacatatgc catgaat                                           27


<210> 2181
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2181
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2182
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2182
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2183
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2183
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2184
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2184
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2185
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2185
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2186
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2186
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2187
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2187
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2188
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2188
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2189
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2190
ggcacagaca agcgcgctcc t                                                 21


<210> 2191
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2191
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2192
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2192
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2193
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2193
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2194
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2194
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2195
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2196
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2196
ttcacctttg acacatatgc catgaat                                           27


<210> 2197
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2197
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2198
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2198
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2199
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2199
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2200
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2200
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2201
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2201
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2202
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2202
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2203
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2203
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2204
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2204
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2205
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2206
ggcacagaca agcgcgctcc t                                                 21


<210> 2207
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2207
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2208
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2208
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2209
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2209
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2210
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2210
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2211
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2212
ttcacctttg acacatatgc catgaat                                           27


<210> 2213
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2213
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2214
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2214
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2215
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2215
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2216
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2216
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2217
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2217
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2218
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2218
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2219
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2219
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2220
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2220
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2221
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2222
ggcacagaca agcgcgctcc t                                                 21


<210> 2223
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2223
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2224
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2224
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2225
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2225
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2226
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2226
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2227
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2228
ttcacctttg acacatatgc catgaat                                           27


<210> 2229
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2229
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2230
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2230
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2231
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2231
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2232
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2232
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2233
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2233
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2234
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2234
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2235
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2235
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2236
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2236
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2237
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2238
ggcacagaca agcgcgctcc t                                                 21


<210> 2239
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2239
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2240
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2240
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2241
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2241
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2242
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2242
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2243
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2244
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2244
ttcacctttg acacatatgc catgaat                                           27


<210> 2245
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2245
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2246
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2246
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2247
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2247
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2248
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2248
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2249
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2249
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2250
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2250
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2251
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2251
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2252
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2252
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2253
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2254
ggcacagaca agcgcgctcc t                                                 21


<210> 2255
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2255
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2256
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2256
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2257
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2257
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2258
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2258
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2259
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2260
ttcacctttg acacatatgc catgaat                                           27


<210> 2261
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2261
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2262
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2262
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2263
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2263
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2264
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2264
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2265
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2265
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2266
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2266
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2267
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2267
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2268
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2268
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2269
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2270
ggcacagaca agcgcgctcc t                                                 21


<210> 2271
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2271
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2272
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2272
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2273
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2273
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2274
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2274
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2275
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2276
ttcacctttg acacatatgc catgaat                                           27


<210> 2277
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2277
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2278
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2278
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2279
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2279
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2280
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2280
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2281
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2281
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2282
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2282
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2283
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2283
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2284
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2284
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2285
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2286
ggcacagaca agcgcgctcc t                                                 21


<210> 2287
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2287
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2288
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2288
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2289
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2289
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2290
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2290
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2291
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2292
ttcacctttg acacatatgc catgaat                                           27


<210> 2293
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2293
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2294
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2294
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2295
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2295
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2296
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2296
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2297
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2297
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2298
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2298
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2299
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2299
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2300
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2300
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2301
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2302
ggcacagaca agcgcgctcc t                                                 21


<210> 2303
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2303
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2304
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2304
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2305
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2305
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2306
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2306
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2307
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2308
ttcacctttg acacatatgc catgaat                                           27


<210> 2309
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2309
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2310
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2310
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2311
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2311
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2312
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2312
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2313
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2313
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2314
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2314
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2315
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2315
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2316
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2316
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2317
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2318
ggcacagaca agcgcgctcc t                                                 21


<210> 2319
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2319
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2320
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2320
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2321
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2321
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2322
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2322
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2323
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2324
ttcacctttg acacatatgc catgaat                                           27


<210> 2325
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2325
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2326
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2326
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2327
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2327
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2328
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2328
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2329
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2329
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2330
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2330
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2331
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2331
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2332
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2332
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2333
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2334
ggcacagaca agcgcgctcc t                                                 21


<210> 2335
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2335
Val Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2336
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2336
gtgctgtggt acaataacct ttgggtg                                           27


<210> 2337
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2337
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2338
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2338
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2339
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2340
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2340
ttcacctttg acacatatgc catgaat                                           27


<210> 2341
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2341
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2342
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2342
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2343
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2343
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2344
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2344
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2345
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2345
agacatgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcccag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2346
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2346
Arg His Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Pro Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2347
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2347
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2348
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2348
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2349
Gly Pro Asp Lys Arg Ala Pro 
1               5           


<210> 2350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2350
ggcccagaca agcgcgctcc t                                                 21


<210> 2351
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2351
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2352
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2352
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2353
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2353
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2354
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2354
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2355
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2356
ttcacctttg acacatatgc catgaat                                           27


<210> 2357
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2357
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2358
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2358
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2359
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2359
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2360
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2360
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2361
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2361
agaactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2362
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2362
Arg Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2363
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2363
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2364
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2364
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2365
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2366
ggcacagaca agcgcgctcc t                                                 21


<210> 2367
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2367
Val Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2368
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2368
gtgctgtggt acaataacct ttgggtg                                           27


<210> 2369
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2369
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2370
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2370
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2371
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2372
ttcacctttg acacatatgc catgaat                                           27


<210> 2373
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2373
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2374
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2374
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2375
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2375
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2376
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2376
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2377
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2377
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2378
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2378
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2379
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2379
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2380
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2380
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2381
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2382
ggcacagaca agcgcgctcc t                                                 21


<210> 2383
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2383
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2384
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2384
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2385
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2385
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2386
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2386
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2387
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2388
ttcacctttg acacatatgc catgaat                                           27


<210> 2389
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2389
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2390
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2390
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2391
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2391
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2392
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2392
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2393
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2393
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2394
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2394
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2395
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2395
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2396
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2396
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2397
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2398
ggcacagaca agcgcgctcc t                                                 21


<210> 2399
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2399
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2400
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2400
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2401
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2401
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2402
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2402
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2403
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2404
ttcacctttg acacatatgc catgaat                                           27


<210> 2405
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2405
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2406
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2406
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2407
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2407
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2408
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2408
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2409
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2409
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2410
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2410
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2411
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2411
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2412
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2412
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2413
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2414
ggcacagaca agcgcgctcc t                                                 21


<210> 2415
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2415
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2416
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2416
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2417
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2417
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2418
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2418
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2419
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2420
ttcacctttg acacatatgc catgaat                                           27


<210> 2421
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2421
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2422
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2422
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2423
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2423
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2424
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2424
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2425
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2425
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2426
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2426
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2427
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2427
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2428
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2428
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2429
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2430
ggcacagaca agcgcgctcc t                                                 21


<210> 2431
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2431
Val Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2432
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2432
gtgctgtggt acagtaacca ttgggtg                                           27


<210> 2433
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2433
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2434
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2434
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2435
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2436
ttcacctttg acacatatgc catgaat                                           27


<210> 2437
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2437
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2438
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2438
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2439
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2439
Val Arg His Gly Asn Phe Gly Asn Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2440
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2440
gtcaggcacg gtaacttcgg gaacggttac gtatcctggt ttgctcat                    48


<210> 2441
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2441
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2442
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2442
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2443
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2443
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2444
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2444
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2445
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2446
ggcacagaca agcgcgctcc t                                                 21


<210> 2447
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2447
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2448
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2448
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2449
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2449
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2450
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2450
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2451
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2452
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2452
ttcacctttg acacatatgc catgaat                                           27


<210> 2453
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2453
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2454
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2454
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2455
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2455
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2456
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2456
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2457
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2457
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2458
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2458
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2459
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2459
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2460
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2460
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2461
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2462
ggcacagaca agcgcgctcc t                                                 21


<210> 2463
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2463
Ala Leu Trp Tyr Asn Asn His Trp Val 
1               5                   


<210> 2464
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2464
gcgctgtggt acaataacca ttgggtg                                           27


<210> 2465
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2465
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2466
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2466
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2467
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2468
ttcacctttg acacatatgc catgaat                                           27


<210> 2469
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2469
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2470
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2470
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2471
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2471
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2472
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2472
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2473
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2473
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2474
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2474
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2475
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2475
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2476
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2476
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2477
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2478
ggcacagaca agcgcgctcc t                                                 21


<210> 2479
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2479
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2480
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2480
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2481
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2481
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2482
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2482
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2483
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2484
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2484
ttcacctttg acacatatgc catgaat                                           27


<210> 2485
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2485
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2486
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2486
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2487
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2487
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2488
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2488
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2489
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2489
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2490
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2490
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2491
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2491
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2492
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2492
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2493
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2493
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2494
ggcacagaca agcgcgctcc t                                                 21


<210> 2495
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2495
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2496
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2496
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2497
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2497
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2498
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2498
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2499
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2499
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2500
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2500
ttcacctttg acacatatgc catgaat                                           27


<210> 2501
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2501
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2502
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2502
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2503
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2503
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2504
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2504
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2505
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2505
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2506
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2506
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2507
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2507
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2508
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2508
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2509
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2509
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2510
ggcacagaca agcgcgctcc t                                                 21


<210> 2511
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2511
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2512
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2512
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2513
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2513
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2514
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2514
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2515
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2516
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2516
ttcacctttg acacatatgc catgaat                                           27


<210> 2517
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2517
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2518
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2518
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2519
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2519
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2520
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2520
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2521
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2521
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2522
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2522
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2523
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2523
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2524
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2524
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2525
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2525
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2526
ggcacagaca agcgcgctcc t                                                 21


<210> 2527
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2527
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2528
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2528
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2529
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2529
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2530
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2530
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2531
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2531
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2532
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2532
ttcacctttg acacatatgc catgaat                                           27


<210> 2533
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2533
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2534
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2534
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2535
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2535
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2536
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2536
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2537
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2537
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2538
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2538
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2539
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2539
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2540
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2540
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2541
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2541
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2542
ggcacagaca agcgcgctcc t                                                 21


<210> 2543
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2543
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2544
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2544
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2545
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2545
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2546
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2546
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2547
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2547
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2548
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2548
ttcacctttg acacatatgc catgaat                                           27


<210> 2549
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2549
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2550
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2550
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2551
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2551
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2552
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2552
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2553
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2553
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2554
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2554
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2555
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2555
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2556
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2556
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2557
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2558
ggcacagaca agcgcgctcc t                                                 21


<210> 2559
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2559
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2560
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2560
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2561
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2561
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2562
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2562
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2563
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2563
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2564
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2564
ttcacctttg acacatatgc catgaat                                           27


<210> 2565
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2565
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2566
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2566
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2567
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2567
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2568
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2568
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2569
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2569
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2570
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2570
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2571
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2571
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2572
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2572
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2573
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2573
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2574
ggcacagaca agcgcgctcc t                                                 21


<210> 2575
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2575
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2576
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2576
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2577
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2577
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2578
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2578
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2579
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2579
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2580
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2580
ttcacctttg acacatatgc catgaat                                           27


<210> 2581
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2581
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2582
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2582
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2583
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2583
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2584
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2584
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2585
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2585
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2586
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2586
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2587
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2587
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2588
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2588
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2589
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2589
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2590
ggcacagaca agcgcgctcc t                                                 21


<210> 2591
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2591
Val Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2592
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2592
gtgctgtggt acaataacct ttgggtg                                           27


<210> 2593
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2593
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2594
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2594
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2595
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2595
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2596
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2596
ttcacctttg acacatatgc catgaat                                           27


<210> 2597
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2597
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2598
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2598
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2599
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2599
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2600
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2600
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2601
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2601
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2602
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2602
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2603
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2603
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2604
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2604
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2605
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2605
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2606
ggcacagaca agcgcgctcc t                                                 21


<210> 2607
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2607
Val Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2608
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2608
gtgctgtggt acagtaacca ttgggtg                                           27


<210> 2609
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2609
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa gggtcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aagtgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2610
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2610
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2611
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2611
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2612
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2612
ttcacctttg acacatatgc catgaat                                           27


<210> 2613
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2613
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 2614
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2614
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaagggt          57


<210> 2615
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2615
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2616
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2616
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2617
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2617
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2618
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2618
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2619
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2619
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2620
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2620
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2621
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2621
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2622
ggcacagaca agcgcgctcc t                                                 21


<210> 2623
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2623
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2624
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2624
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2625
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2625
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2626
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2626
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2627
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2627
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2628
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2628
ttcacctttg acacatatgc catgaat                                           27


<210> 2629
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2629
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2630
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2630
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2631
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2631
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2632
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2632
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2633
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2633
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggtc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2634
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2634
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Val 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2635
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2635
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2636
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2636
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2637
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2637
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2638
ggcacagaca agcgcgctcc t                                                 21


<210> 2639
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2639
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2640
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2640
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2641
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2641
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2642
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2642
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2643
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2643
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2644
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2644
ttcacctttg acacatatgc catgaat                                           27


<210> 2645
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2645
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2646
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2646
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2647
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2647
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2648
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2648
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2649
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2649
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcatcat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2650
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2650
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2651
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2651
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2652
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2652
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2653
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2653
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2654
ggcacagaca agcgcgctcc t                                                 21


<210> 2655
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2655
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2656
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2656
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2657
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2657
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2658
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2658
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2659
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2659
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2660
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2660
ttcacctttg acacatatgc catgaat                                           27


<210> 2661
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2661
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2662
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2662
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2663
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2663
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2664
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2664
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2665
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2665
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcgctgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2666
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2666
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Ala Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2667
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2667
Gly Ser Ser Ala Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2668
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2668
ggatcaagcg ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2669
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2669
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2670
ggcacagaca agcgcgctcc t                                                 21


<210> 2671
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2671
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2672
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2672
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2673
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2673
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2674
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2674
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2675
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2675
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2676
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2676
ttcacctttg acacatatgc catgaat                                           27


<210> 2677
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2677
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2678
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2678
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2679
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2679
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2680
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2680
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2681
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2681
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2682
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2682
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2683
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2683
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2684
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2684
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2685
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2685
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2686
ggcacagaca agcgcgctcc t                                                 21


<210> 2687
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2687
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2688
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2688
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 2689
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2689
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2690
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2690
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2691
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2691
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2692
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2692
ttcacctttg acacatatgc catgaat                                           27


<210> 2693
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2693
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2694
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2694
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2695
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2695
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2696
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2696
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2697
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2697
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acaataacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2698
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2698
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Asn Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2699
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2699
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2700
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2700
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2701
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2701
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2702
ggcacagaca agcgcgctcc t                                                 21


<210> 2703
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2703
Ala Leu Trp Tyr Asn Asn Leu Trp Val 
1               5                   


<210> 2704
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2704
gcgctgtggt acaataacct ttgggtg                                           27


<210> 2705
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2705
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2706
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2706
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2707
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2707
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2708
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2708
ttcacctttg acacatatgc catgaat                                           27


<210> 2709
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2709
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2710
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2710
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2711
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2711
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2712
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2712
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2713
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2713
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gtgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2714
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2714
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2715
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2715
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2716
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2716
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2717
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2717
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2718
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2718
ggcacagaca agcgcgctcc t                                                 21


<210> 2719
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2719
Val Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 2720
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2720
gtgctgtggt acagtaacct ttgggtg                                           27


<210> 2721
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2721
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2722
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2722
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2723
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2723
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2724
ttcacctttg acacatatgc catgaat                                           27


<210> 2725
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2725
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2726
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2726
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2727
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2727
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2728
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2728
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2729
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2729
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2730
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2730
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2731
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2731
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2732
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2732
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2733
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2733
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2734
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2734
ggcacagaca agcgcgctcc t                                                 21


<210> 2735
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2735
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2736
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2736
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 2737
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2737
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc gccatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacagtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2738
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2738
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2739
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2739
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 2740
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2740
ttcacctttg acacatatgc catgaat                                           27


<210> 2741
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2741
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 2742
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2742
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 2743
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2743
Val Arg His Ser Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 2744
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2744
gtcaggcaca gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 2745
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2745
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gtgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 2746
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2746
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2747
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2747
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 2748
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2748
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 2749
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2749
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 2750
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2750
ggcacagaca agcgcgctcc t                                                 21


<210> 2751
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2751
Val Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 2752
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2752
gtgctgtggt acagtaacca ttgggtg                                           27


<210> 2753
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2753
caggtacagc tgcagcagtc aggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcata agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaaggccaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagtctgac ctctgaggac tctgcggtct atttctgtgc aagagatgat      300

aactactcct ttgcttactg gggccaaggc aaccacggtc accgtctcct c               351


<210> 2754
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2754
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Asn Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Asn His 
            100                 105                 110         


Gly His Arg Leu Leu 
        115         


<210> 2755
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2755
Tyr Thr Phe Ile Ser Tyr Tyr Ile His 
1               5                   


<210> 2756
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2756
tacaccttca taagctacta tatacac                                           27


<210> 2757
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2757
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210> 2758
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2758
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggc c                51


<210> 2759
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2759
Ala Arg Asp Asp Asn Tyr Ser Phe Ala Tyr 
1               5                   10  


<210> 2760
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2760
gcaagagatg ataactactc ctttgcttac                                        30


<210> 2761
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2761
gacatcgtga tgatccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggaa ataaaa                                336


<210> 2762
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2762
Asp Ile Val Met Ile Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 2763
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2763
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2764
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2764
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2765
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2765
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2766
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2766
tgggcatcca ctagggaatc t                                                 21


<210> 2767
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2767
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2768
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2768
aagcaatctt ataatcttcg gacg                                              24


<210> 2769
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2769
gaagtacagc tgcagcagtc tggacctgac ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cgccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcttg gagatggtag tactaactac      180

aatgagaagt tcaagggcaa gaccacactg actgcagaca aatcctccag cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcgacct atttctgtgc aagggatgat      300

tcgtactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2770
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2770
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Leu Gly Asp Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2771
Tyr Ala Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2772
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2772
tacgccttca caagctacta tatacac                                           27


<210> 2773
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2773
Trp Ile Tyr Leu Gly Asp Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2774
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2774
tggatttatc ttggagatgg tagtactaac tacaatgaga agttcaaggg c                51


<210> 2775
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2775
Ala Arg Asp Asp Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2776
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2776
gcaagggatg attcgtacta ctttgactac                                        30


<210> 2777
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2777
gacattcagc tcactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccaac agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatagtctt      300

cggacgttcg gtggagggac caagctggaa atcaaa                                336


<210> 2778
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2778
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 2779
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2779
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2780
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2780
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2781
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2781
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2782
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2782
tgggcatcca ctagggaatc t                                                 21


<210> 2783
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2783
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 2784
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2784
aagcaatctt atagtcttcg gacg                                              24


<210> 2785
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2785
caggtgaagc tggaggagtc aggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca cgctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaaatac      180

aatgagaagt tcaagggcaa ggccacactg tctgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatggt      300

gattactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2786
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2786
Gln Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2787
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2787
Tyr Thr Phe Thr Arg Tyr Tyr Ile His 
1               5                   


<210> 2788
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2788
tacaccttca cacgctacta tatacac                                           27


<210> 2789
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2789
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2790
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2790
tggatttatc ctggaaatgt taatactaaa tacaatgaga agttcaaggg c                51


<210> 2791
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2791
Ala Arg Asp Gly Asp Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2792
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2792
gcaagagatg gtgattacta ctttgactac                                        30


<210> 2793
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2793
gacattcagc tcactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210> 2794
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2794
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 2795
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2795
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2796
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2796
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2797
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2798
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2798
tgggcatcca ctagggaatc t                                                 21


<210> 2799
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2799
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2800
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2800
aagcaatctt ataatcttcg gacg                                              24


<210> 2801
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2801
gaggtgcagc tgcaggagtc tggacctgag ctggtgaaac ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatggt      300

gattactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2802
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2802
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2803
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2803
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2804
tacaccttca caagctacta tatacac                                           27


<210> 2805
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2805
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2806
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2806
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2807
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2807
Ala Arg Asp Gly Asp Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2808
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2808
gcaagagatg gtgattacta ctttgactac                                        30


<210> 2809
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2809
gacattcagc tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2810
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2810
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2811
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2811
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2812
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2812
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2813
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2813
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2814
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2814
tgggcatcca ctagggaatc t                                                 21


<210> 2815
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2815
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2816
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2816
aagcaatctt ataatcttcg gacg                                              24


<210> 2817
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2817
gaggtcaagc tggaggagtc aggacctgag ctggcgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatggt      300

aactacttct tcgatgtctg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2818
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2818
Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Tyr Phe Phe Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2819
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2819
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2820
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2820
tacaccttca caagctacta tatacac                                           27


<210> 2821
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2821
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2822
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2822
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2823
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2823
Ala Arg Asp Gly Asn Tyr Phe Phe Asp Val 
1               5                   10  


<210> 2824
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2824
gcaagagatg gtaactactt cttcgatgtc                                        30


<210> 2825
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2825
gacatccagc tgactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacctggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataacctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2826
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2826
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2827
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2827
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2828
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2828
aaatccagtc agagtctgct caacagtaga acccgaaaga actacctggc t                51


<210> 2829
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2829
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2830
tgggcatcca ctagggaatc t                                                 21


<210> 2831
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2831
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2832
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2832
aagcaatctt ataaccttcg gacg                                              24


<210> 2833
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2833
gaggttcagc tggaggagtc tggacctgaa ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcaatct atttctgtgc aagagatggt      300

aactacttct tcgatgtctg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2834
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2834
Glu Val Gln Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Tyr Phe Phe Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2835
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2835
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2836
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2836
tacaccttca caagctacta tatacac                                           27


<210> 2837
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2837
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2838
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2838
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2839
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2839
Ala Arg Asp Gly Asn Tyr Phe Phe Asp Val 
1               5                   10  


<210> 2840
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2840
gcaagagatg gtaactactt cttcgatgtc                                        30


<210> 2841
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2841
gatatcgagc tgattcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gaatctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccggc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtatattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2842
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2842
Asp Ile Glu Leu Ile Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2843
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2843
Lys Ser Ser Gln Asn Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2844
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2844
aaatccagtc agaatctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2845
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2845
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2846
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2846
tgggcatcca ctagggaatc t                                                 21


<210> 2847
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2847
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2848
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2848
aagcaatctt ataatcttcg gacg                                              24


<210> 2849
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2849
caggtaaagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcaa caccttcaca agctcctata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagtctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagacggt      300

agtagctact actttgacta ctggggccaa ggcaccacgg tcaccgtctc ctca            354


<210> 2850
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2850
Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 2851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2851
Asn Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 2852
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2852
aacaccttca caagctccta tatacac                                           27


<210> 2853
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2853
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2854
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2854
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2855
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2855
Ala Arg Asp Gly Ser Ser Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210> 2856
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2856
gcaagagacg gtagtagcta ctactttgac tac                                    33


<210> 2857
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2857
gacatccagc tgactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2858
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2858
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2859
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2859
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2860
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2860
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2861
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2861
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2862
tgggcatcca ctagggaatc t                                                 21


<210> 2863
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2863
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2864
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2864
aagcaatctt ataatcttcg gacg                                              24


<210> 2865
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2865
gaagtgcagc tggagcagtc aggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gagatggtag tactaagtac      180

aatgagaagt tcaagggcaa gaccacactg actgcagaca aatcctccag cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcgatct atttctgtgc aagggatggt      300

tcgtactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2866
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2866
Glu Val Gln Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2867
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2867
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2868
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2868
tacaccttca caagctacta tatacac                                           27


<210> 2869
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2869
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2870
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2870
tggatttatc ctggagatgg tagtactaag tacaatgaga agttcaaggg c                51


<210> 2871
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2871
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2872
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2872
gcaagggatg gttcgtacta ctttgactac                                        30


<210> 2873
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2873
gacattcagc tcacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccaac agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatagtctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2874
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2874
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2875
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2875
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2876
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2876
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2877
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2877
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2878
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2878
tgggcatcca ctagggaatc t                                                 21


<210> 2879
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2879
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 2880
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2880
aagcaatctt atagtcttcg gacg                                              24


<210> 2881
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2881
gaggtgaagc tggaggagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gagatggtag tactaagtac      180

aatgagaagt tcaagggcaa gaccacactg actgcagaca aatcctccag cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcgatct atttctgtgc aagggatggt      300

tcgtactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2882
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2882
Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2883
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2883
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2884
tacaccttca caagctacta tatacac                                           27


<210> 2885
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2885
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2886
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2886
tggatttatc ctggagatgg tagtactaag tacaatgaga agttcaaggg c                51


<210> 2887
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2887
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2888
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2888
gcaagggatg gttcgtacta ctttgactac                                        30


<210> 2889
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2889
gacatccagc tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccaac agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatagtctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2890
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2890
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2891
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2891
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2892
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2892
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2893
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2893
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2894
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2894
tgggcatcca ctagggaatc t                                                 21


<210> 2895
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2895
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 2896
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2896
aagcaatctt atagtcttcg gacg                                              24


<210> 2897
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2897
gaagtcaagc tgcaggagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gagatggtag tactaagtac      180

aatgagaagt tcaagggcaa gaccacactg actgcagaca aatcctccag cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcgatct atttctgtgc aagggactac      300

gggtactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2898
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2898
Glu Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2899
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2899
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2900
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2900
tacaccttca caagctacta tatacac                                           27


<210> 2901
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2901
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2902
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2902
tggatttatc ctggagatgg tagtactaag tacaatgaga agttcaaggg c                51


<210> 2903
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2903
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2904
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2904
gcaagggact acgggtacta ctttgactac                                        30


<210> 2905
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2905
gacattcagc tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2906
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2906
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2907
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2907
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2908
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2908
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2909
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2909
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2910
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2910
tgggcatcca ctagggaatc t                                                 21


<210> 2911
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2911
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2912
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2912
aagcaatctt ataatcttcg gacg                                              24


<210> 2913
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2913
gaggttaagc tggaggagtc aggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagtttat      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagactat      300

ggttactact ttgactattg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2914
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2914
Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2915
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2915
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2916
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2916
tacaccttca caagctacta tatacac                                           27


<210> 2917
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2917
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2918
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2918
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2919
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2919
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2920
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2920
gcaagagact atggttacta ctttgactat                                        30


<210> 2921
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2921
gacattgtgc tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcacc       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2922
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2922
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2923
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2923
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2924
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2924
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2925
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2925
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2926
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2926
tgggcatcca ctagggaatc t                                                 21


<210> 2927
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2927
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2928
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2928
aagcaatctt ataatcttcg gacg                                              24


<210> 2929
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2929
gaggtgcagc tggaggagtc aggacctgag ctggtgaggc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctcctata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcacctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagactat      300

ggttactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2930
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2930
Glu Val Gln Leu Glu Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2931
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2931
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 2932
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2932
tacaccttca caagctccta tatacac                                           27


<210> 2933
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2933
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2934
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2934
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2935
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2935
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2936
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2936
gcaagagact atggttacta ctttgactac                                        30


<210> 2937
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2937
gacattgtgc tgacccaatc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaagcagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 2938
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2938
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 2939
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2939
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2940
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2940
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2941
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2941
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2942
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2942
tgggcatcca ctagggaatc t                                                 21


<210> 2943
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2943
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2944
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2944
aagcaatctt ataatcttcg gacg                                              24


<210> 2945
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2945
gaggttcagc tggagcagtc aggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagt cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaaatac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagactat      300

ggttactact ttggctcctg gggccaaggc accacggtca ccgtctcctc a               351


<210> 2946
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2946
Glu Val Gln Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Gly Ser Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2947
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2947
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2948
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2948
tacaccttca caagctacta tatacac                                           27


<210> 2949
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2949
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2950
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2950
tggatttatc ctggaaatgt taatactaaa tacaatgaga agttcaaggg c                51


<210> 2951
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2951
Ala Arg Asp Tyr Gly Tyr Tyr Phe Gly Ser 
1               5                   10  


<210> 2952
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2952
gcaagagact atggttacta ctttggctcc                                        30


<210> 2953
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2953
gacatccagc tcacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgaactgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaattgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtaagcaatc ttataatctt      300

cggacgttcg gtggaggcac aaagctggaa atcaaa                                336


<210> 2954
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2954
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 2955
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2955
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2956
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2956
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2957
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2957
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2958
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2958
tgggcatcca ctagggaatc t                                                 21


<210> 2959
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2959
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2960
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2960
aagcaatctt ataatcttcg gacg                                              24


<210> 2961
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2961
gaagtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggtta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagtctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgg aagagattac      300

tacggctcgt actactttga caactggggc caaggcacca cggtcaccgt ctcctca         357


<210> 2962
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2962
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Gly Arg Asp Tyr Tyr Gly Ser Tyr Tyr Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 2963
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2963
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2964
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2964
tacaccttca caagctacta tatacac                                           27


<210> 2965
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2965
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2966
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2966
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 2967
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2967
Gly Arg Asp Tyr Tyr Gly Ser Tyr Tyr Phe Asp Asn 
1               5                   10          


<210> 2968
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2968
ggaagagatt actacggctc gtactacttt gacaac                                 36


<210> 2969
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2969
gacatccagc tgactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagcctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga ggacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac aaagttggaa ataaaa                                336


<210> 2970
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2970
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 2971
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2971
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2972
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2972
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 2973
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2973
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2974
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2974
tgggcatcca ctagggaatc t                                                 21


<210> 2975
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2975
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 2976
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2976
aagcaatctt ataatcttcg gacg                                              24


<210> 2977
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2977
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggatggc      300

tcctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 2978
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2978
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2979
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2979
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2980
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2980
tacaccttca ccagctacta tatacac                                           27


<210> 2981
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2981
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2982
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2982
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 2983
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2983
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 2984
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 2984
gctagggatg gctcctacta ctttgactac                                        30


<210> 2985
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 2985
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 2986
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 2986
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 2987
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 2987
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 2988
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 2988
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 2989
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 2989
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 2990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 2990
tgggcatcta cccgggaatc c                                                 21


<210> 2991
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 2991
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 2992
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 2992
aagcaatctt attctctgag aact                                              24


<210> 2993
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 2993
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccata accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggatgga      300

agctattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 2994
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 2994
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2995
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 2995
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 2996
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 2996
tacaccttca ccagctacta tatacac                                           27


<210> 2997
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 2997
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 2998
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 2998
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 2999
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 2999
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3000
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3000
gcgagggatg gaagctatta ctttgactac                                        30


<210> 3001
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3001
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3002
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3002
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3003
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3003
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3004
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3004
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3005
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3005
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3006
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3006
tgggcatcta cccgggaatc c                                                 21


<210> 3007
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3007
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3008
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3008
aagcaatctt attctctgag aact                                              24


<210> 3009
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3009
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagggatggt      300

tcctattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3010
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3010
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3011
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3011
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3012
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3012
tacaccttca ccagctacta tatacac                                           27


<210> 3013
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3013
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3014
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3014
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3015
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3015
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3016
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3016
gccagggatg gttcctatta ctttgactac                                        30


<210> 3017
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3017
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3018
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3018
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3019
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3019
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3020
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3020
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3021
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3021
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3022
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3022
tgggcatcta cccgggaatc c                                                 21


<210> 3023
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3023
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3024
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3024
aagcaatctt attctctgag aact                                              24


<210> 3025
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3025
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagatggc      300

tcatattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3026
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3026
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3027
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3027
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3028
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3028
tacaccttca ccagctacta tatacac                                           27


<210> 3029
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3029
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3030
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3030
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3031
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3031
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3032
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3032
gctagagatg gctcatatta ctttgactac                                        30


<210> 3033
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3033
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3034
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3034
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3035
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3035
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3036
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3036
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3037
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3037
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3038
tgggcatcta cccgggaatc c                                                 21


<210> 3039
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3039
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3040
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3040
aagcaatctt attctctgag aact                                              24


<210> 3041
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3041
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag aaccaccctg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagacgga      300

tcttattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3042
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3042
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Thr Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3043
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3043
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3044
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3044
tacaccttca ccagctacta tatacac                                           27


<210> 3045
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3045
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3046
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3046
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3047
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3047
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3048
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3048
gctagagacg gatcttatta ctttgactac                                        30


<210> 3049
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3049
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3050
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3050
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3051
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3051
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3052
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3052
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3053
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3053
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3054
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3054
tgggcatcta cccgggaatc c                                                 21


<210> 3055
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3055
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3056
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3056
aagcaatctt attctctgag aact                                              24


<210> 3057
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3057
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag aaccaccctg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagagatggt      300

agctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3058
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3058
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Thr Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3059
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3059
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3060
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3060
tacaccttca ccagctacta tatacac                                           27


<210> 3061
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3061
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3062
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3062
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3063
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3063
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3064
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3064
gcgagagatg gtagctacta ctttgactac                                        30


<210> 3065
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3065
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctt      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3066
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3066
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3067
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3067
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3068
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3068
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3069
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3069
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3070
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3070
tgggcatcta cccgggaatc c                                                 21


<210> 3071
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3071
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3072
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3072
aagcaatctt attctcttag aact                                              24


<210> 3073
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3073
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggatggc      300

tcctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3074
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3074
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3075
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3075
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3076
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3076
tacaccttca ccagctacta tatacac                                           27


<210> 3077
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3077
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3078
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3078
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3079
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3079
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3080
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3080
gctagggatg gctcctacta ctttgactac                                        30


<210> 3081
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3081
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3082
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3082
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3083
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3083
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3084
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3084
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3085
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3085
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3086
tgggcatcta cccgggaatc c                                                 21


<210> 3087
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3087
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3088
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3088
aagcagagtt acaatttgag aact                                              24


<210> 3089
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3089
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccata accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggatgga      300

agctattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3090
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3090
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3091
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3091
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3092
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3092
tacaccttca ccagctacta tatacac                                           27


<210> 3093
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3093
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3094
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3094
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3095
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3095
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3096
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3096
gcgagggatg gaagctatta ctttgactac                                        30


<210> 3097
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3097
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3098
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3098
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3099
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3099
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3100
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3100
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3101
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3102
tgggcatcta cccgggaatc c                                                 21


<210> 3103
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3103
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3104
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3104
aagcagagtt acaatttgag aact                                              24


<210> 3105
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3105
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagggatggt      300

tcctattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3106
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3107
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3108
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3108
tacaccttca ccagctacta tatacac                                           27


<210> 3109
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3109
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3110
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3110
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3111
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3111
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3112
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3112
gccagggatg gttcctatta ctttgactac                                        30


<210> 3113
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3113
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3114
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3114
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3115
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3115
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3116
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3116
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3117
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3117
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3118
tgggcatcta cccgggaatc c                                                 21


<210> 3119
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3119
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3120
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3120
aagcagagtt acaatttgag aact                                              24


<210> 3121
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3121
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagatggc      300

tcatattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3122
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3122
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3123
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3123
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3124
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3124
tacaccttca ccagctacta tatacac                                           27


<210> 3125
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3125
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3126
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3126
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3127
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3127
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3128
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3128
gctagagatg gctcatatta ctttgactac                                        30


<210> 3129
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3129
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3130
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3130
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3131
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3131
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3132
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3132
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3133
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3133
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3134
tgggcatcta cccgggaatc c                                                 21


<210> 3135
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3135
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3136
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3136
aagcagagtt acaatttgag aact                                              24


<210> 3137
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3137
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag aaccaccctg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagacgga      300

tcttattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3138
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3138
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Thr Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3139
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3139
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3140
tacaccttca ccagctacta tatacac                                           27


<210> 3141
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3141
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3142
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3142
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3143
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3143
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3144
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3144
gctagagacg gatcttatta ctttgactac                                        30


<210> 3145
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3145
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3146
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3146
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3147
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3147
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3148
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3148
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3149
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3149
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3150
tgggcatcta cccgggaatc c                                                 21


<210> 3151
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3151
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3152
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3152
aagcagagtt acaatttgag aact                                              24


<210> 3153
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3153
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag aaccaccctg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagagatggt      300

agctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3154
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3154
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Thr Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3155
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3155
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 3156
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3156
tacaccttca ccagctacta tatacac                                           27


<210> 3157
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3157
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3158
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3158
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3159
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3159
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3160
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3160
gcgagagatg gtagctacta ctttgactac                                        30


<210> 3161
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3161
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caagctggag atcaaa                                336


<210> 3162
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3162
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 3163
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3163
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3164
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3164
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3165
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3165
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3166
tgggcatcta cccgggaatc c                                                 21


<210> 3167
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3167
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3168
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3168
aagcagagtt acaatttgag aact                                              24


<210> 3169
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3169
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccata accagggaca cgtccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggattat      300

ggctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3170
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3170
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3171
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3172
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3172
tacaccttca ccagctccta tatacac                                           27


<210> 3173
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3173
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3174
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3174
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3175
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3175
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3176
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3176
gctagggatt atggctacta ctttgactac                                        30


<210> 3177
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3177
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3178
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3178
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3179
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3179
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3180
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3180
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3181
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3181
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3182
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3182
tgggcatcta cccgggaatc c                                                 21


<210> 3183
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3183
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3184
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3184
aagcaatctt attctctgag aact                                              24


<210> 3185
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3185
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agccaccctg accgcggaca agtccgcgag cacagcctac      240

atgcacctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagagactac      300

ggctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3186
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3186
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3187
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3188
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3188
tacaccttca ccagctccta tatacac                                           27


<210> 3189
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3189
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3190
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3190
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3191
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3191
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3192
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3192
gcgagagact acggctacta ctttgactac                                        30


<210> 3193
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3193
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3194
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3194
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3195
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3195
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3196
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3196
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3197
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3197
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3198
tgggcatcta cccgggaatc c                                                 21


<210> 3199
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3199
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3200
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3200
aagcaatctt attctctgag aact                                              24


<210> 3201
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3201
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccata accgcggaca agtccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggattac      300

ggatactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3202
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3202
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3203
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3203
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3204
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3204
tacaccttca ccagctccta tatacac                                           27


<210> 3205
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3205
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3206
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3206
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3207
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3207
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3208
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3208
gcgagggatt acggatacta ctttgactac                                        30


<210> 3209
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3209
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3210
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3210
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3211
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3211
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3212
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3212
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3213
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3214
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3214
tgggcatcta cccgggaatc c                                                 21


<210> 3215
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3215
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3216
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3216
aagcaatctt attctctgag aact                                              24


<210> 3217
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3217
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggactat      300

ggttactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3218
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3218
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3219
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3220
tacaccttca ccagctccta tatacac                                           27


<210> 3221
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3221
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3222
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3222
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3223
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3223
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3224
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3224
gctagggact atggttacta ctttgactac                                        30


<210> 3225
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3225
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3226
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3226
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3227
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3227
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3228
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3228
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3229
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3230
tgggcatcta cccgggaatc c                                                 21


<210> 3231
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3231
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3232
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3232
aagcaatctt attctctgag aact                                              24


<210> 3233
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3233
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggactac      300

ggttattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3234
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3234
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3235
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3236
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3236
tacaccttca ccagctccta tatacac                                           27


<210> 3237
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3237
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3238
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3238
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3239
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3239
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3240
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3240
gctagggact acggttatta ctttgactac                                        30


<210> 3241
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3241
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3242
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3242
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3243
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3243
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3244
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3244
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3245
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3246
tgggcatcta cccgggaatc c                                                 21


<210> 3247
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3247
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3248
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3248
aagcaatctt attctctgag aact                                              24


<210> 3249
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3249
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agccaccctg accgcggaca agtccacgag cacagcctac      240

atgcacctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggactat      300

ggctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3250
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3250
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3251
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3252
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3252
tacaccttca ccagctccta tatacac                                           27


<210> 3253
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3253
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3254
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3254
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3255
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3255
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3256
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3256
gcgagggact atggctacta ctttgactac                                        30


<210> 3257
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3257
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3258
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3258
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3259
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3259
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3260
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3260
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3261
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3262
tgggcatcta cccgggaatc c                                                 21


<210> 3263
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3263
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3264
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3264
aagcaatctt attctctgag aact                                              24


<210> 3265
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3265
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccata accagggaca cgtccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggattat      300

ggctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3266
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3266
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3267
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3268
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3268
tacaccttca ccagctccta tatacac                                           27


<210> 3269
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3269
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3270
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3270
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3271
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3271
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3272
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3272
gctagggatt atggctacta ctttgactac                                        30


<210> 3273
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3273
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3274
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3274
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3275
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3275
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3276
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3276
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3277
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3277
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3278
tgggcatcta cccgggaatc c                                                 21


<210> 3279
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3279
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3280
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3280
aagcagagtt acaatttgag aact                                              24


<210> 3281
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3281
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agccaccctg accgcggaca agtccgcgag cacagcctac      240

atgcacctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagagactac      300

ggctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3282
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3282
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3283
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3283
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3284
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3284
tacaccttca ccagctccta tatacac                                           27


<210> 3285
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3285
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3286
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3286
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3287
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3287
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3288
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3288
gcgagagact acggctacta ctttgactac                                        30


<210> 3289
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3289
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3290
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3290
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3291
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3291
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3292
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3292
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3293
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3294
tgggcatcta cccgggaatc c                                                 21


<210> 3295
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3295
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3296
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3296
aagcagagtt acaatttgag aact                                              24


<210> 3297
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3297
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccata accgcggaca agtccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggattac      300

ggatactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3298
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3298
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3299
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3300
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3300
tacaccttca ccagctccta tatacac                                           27


<210> 3301
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3301
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3302
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3302
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3303
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3303
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3304
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3304
gcgagggatt acggatacta ctttgactac                                        30


<210> 3305
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3305
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3306
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3306
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3307
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3307
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3308
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3308
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3309
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3310
tgggcatcta cccgggaatc c                                                 21


<210> 3311
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3311
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3312
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3312
aagcagagtt acaatttgag aact                                              24


<210> 3313
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3313
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggactat      300

ggttactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3314
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3314
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3315
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3315
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3316
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3316
tacaccttca ccagctccta tatacac                                           27


<210> 3317
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3317
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3318
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3318
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3319
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3319
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3320
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3320
gctagggact atggttacta ctttgactac                                        30


<210> 3321
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3321
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3322
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3322
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3323
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3323
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3324
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3324
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3325
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3326
tgggcatcta cccgggaatc c                                                 21


<210> 3327
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3327
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3328
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3328
aagcagagtt acaatttgag aact                                              24


<210> 3329
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3329
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagggactac      300

ggttattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3330
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3330
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3331
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3332
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3332
tacaccttca ccagctccta tatacac                                           27


<210> 3333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3333
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3334
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3334
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3335
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3335
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3336
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3336
gctagggact acggttatta ctttgactac                                        30


<210> 3337
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3337
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctaggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3338
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3338
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3339
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3339
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3340
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3340
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3341
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3341
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3342
tgggcatcta cccgggaatc c                                                 21


<210> 3343
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3343
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3344
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3344
aagcagagtt acaatttgag aact                                              24


<210> 3345
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3345
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttaa cacaaagtac      180

aacgagaagt tcaagggcag agccaccctg accgcggaca agtccacgag cacagcctac      240

atgcacctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggactat      300

ggctactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3346
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3346
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3347
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3347
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3348
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3348
tacaccttca ccagctccta tatacac                                           27


<210> 3349
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3349
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3350
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3350
tggatctacc ctggtaatgt taacacaaag tacaacgaga agttcaaggg c                51


<210> 3351
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3351
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3352
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3352
gcgagggact atggctacta ctttgactac                                        30


<210> 3353
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3353
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3354
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3354
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3355
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3355
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3356
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3356
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3357
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3357
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3358
tgggcatcta cccgggaatc c                                                 21


<210> 3359
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3359
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3360
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3360
aagcagagtt acaatttgag aact                                              24


<210> 3361
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3361
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcgaccctg aaaatggtaa cacaatctac      180

gacccgaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagacgga      300

tatgcaaggt attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3362
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3362
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3363
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3364
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3364
ttcaacatca aggactacta tatgcac                                           27


<210> 3365
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3365
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3366
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3366
tggatcgacc ctgaaaatgg taacacaatc tacgacccga agttccaggg c                51


<210> 3367
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3367
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3368
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3368
gctagagacg gatatgcaag gtattacttt gactac                                 36


<210> 3369
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3369
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3370
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3370
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3371
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3371
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3372
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3372
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3373
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3373
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3374
tgggcatcta cccgggaatc c                                                 21


<210> 3375
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3375
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3376
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3376
aagcaatctt attctctgag aact                                              24


<210> 3377
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3377
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctac      180

gacccgaagt tccagggcag agtcaccatg accgcggaca cgtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggacggt      300

tatgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3378
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3378
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3379
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3379
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3380
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3380
ttcaacatca aggactacta tatgcac                                           27


<210> 3381
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3381
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3382
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3382
tggatcgacc ctgaaaatgg taacacaatc tacgacccga agttccaggg c                51


<210> 3383
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3383
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3384
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3384
gcgagggacg gttatgctag atattacttt gactac                                 36


<210> 3385
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3385
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3386
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3386
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3387
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3387
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3388
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3388
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3389
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3390
tgggcatcta cccgggaatc c                                                 21


<210> 3391
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3391
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3392
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3392
aagcaatctt attctctgag aact                                              24


<210> 3393
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3393
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctac      180

gacccgaagt tccagggcag agccaccata accgcggaca cgtccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatggt      300

tatgccagat actactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3394
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3394
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3395
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3396
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3396
ttcaacatca aggactacta tatgcac                                           27


<210> 3397
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3397
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3398
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3398
tggatcgacc ctgaaaatgg taacacaatc tacgacccga agttccaggg c                51


<210> 3399
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3399
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3400
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3400
gccagagatg gttatgccag atactacttt gactac                                 36


<210> 3401
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3401
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3402
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3402
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3403
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3403
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3404
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3404
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3405
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3406
tgggcatcta cccgggaatc c                                                 21


<210> 3407
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3407
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3408
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3408
aagcaatctt attctctgag aact                                              24


<210> 3409
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3409
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3410
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3410
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3411
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3412
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3412
ttcaacatca aggactacta tatgcac                                           27


<210> 3413
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3413
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3414
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3414
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3415
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3415
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3416
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3416
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3417
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3417
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3418
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3418
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3419
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3419
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3420
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3420
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3421
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3421
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3422
tgggcatcta cccgggaatc c                                                 21


<210> 3423
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3423
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3424
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3424
aagcaatctt attctctgag aact                                              24


<210> 3425
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3425
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accgcggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc tagagacggt      300

tacgccagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3426
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3426
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3427
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3427
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3428
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3428
ttcaacatca aggactacta tatgcac                                           27


<210> 3429
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3429
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3430
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3430
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3431
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3431
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3432
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3432
gctagagacg gttacgccag atattacttt gactac                                 36


<210> 3433
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3433
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3434
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3434
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3435
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3435
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3436
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3436
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3437
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3437
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3438
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3438
tgggcatcta cccgggaatc c                                                 21


<210> 3439
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3439
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3440
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3440
aagcaatctt attctctgag aact                                              24


<210> 3441
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3441
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggccaccata accgcggaca cgtccgccaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagacgga      300

tacgcgagat actactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3442
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3442
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3443
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3444
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3444
ttcaacatca aggactacta tatgcac                                           27


<210> 3445
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3445
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3446
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3446
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3447
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3447
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3448
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3448
gcgagagacg gatacgcgag atactacttt gactac                                 36


<210> 3449
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3449
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3450
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3450
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3451
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3451
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3452
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3452
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3453
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3453
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3454
tgggcatcta cccgggaatc c                                                 21


<210> 3455
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3455
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3456
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3456
aagcaatctt attctctgag aact                                              24


<210> 3457
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3457
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcgaccctg aaaatggtaa cacaatctac      180

gacccgaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagacgga      300

tatgcaaggt attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3458
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3458
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3459
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3460
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3460
ttcaacatca aggactacta tatgcac                                           27


<210> 3461
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3461
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3462
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3462
tggatcgacc ctgaaaatgg taacacaatc tacgacccga agttccaggg c                51


<210> 3463
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3463
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3464
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3464
gctagagacg gatatgcaag gtattacttt gactac                                 36


<210> 3465
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3465
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3466
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3466
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3467
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3467
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3468
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3468
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3469
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3469
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3470
tgggcatcta cccgggaatc c                                                 21


<210> 3471
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3471
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3472
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3472
aagcagagtt acaatttgag aact                                              24


<210> 3473
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3473
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctac      180

gacccgaagt tccagggcag agccaccata accgcggaca cgtccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatggt      300

tatgccagat actactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3474
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3474
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3475
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3476
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3476
ttcaacatca aggactacta tatgcac                                           27


<210> 3477
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3477
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3478
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3478
tggatcgacc ctgaaaatgg taacacaatc tacgacccga agttccaggg c                51


<210> 3479
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3479
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3480
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3480
gccagagatg gttatgccag atactacttt gactac                                 36


<210> 3481
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3481
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3482
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3482
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3483
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3483
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3484
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3484
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3485
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3485
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3486
tgggcatcta cccgggaatc c                                                 21


<210> 3487
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3487
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3488
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3488
aagcagagtt acaatttgag aact                                              24


<210> 3489
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3489
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3490
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3490
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3491
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3492
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3492
ttcaacatca aggactacta tatgcac                                           27


<210> 3493
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3493
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3494
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3494
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3495
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3495
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3496
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3496
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3497
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3497
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agtgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3498
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3498
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3499
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3499
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3500
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3500
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3501
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3501
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3502
tgggcatcta cccgggaatc c                                                 21


<210> 3503
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3503
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3504
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3504
aagcagagtt acaatttgag aact                                              24


<210> 3505
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3505
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accgcggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc tagagacggt      300

tacgccagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3506
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3506
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3507
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3507
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3508
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3508
ttcaacatca aggactacta tatgcac                                           27


<210> 3509
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3509
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3510
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3510
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3511
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3511
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3512
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3512
gctagagacg gttacgccag atattacttt gactac                                 36


<210> 3513
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3513
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3514
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3514
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3515
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3515
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3516
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3516
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3517
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3518
tgggcatcta cccgggaatc c                                                 21


<210> 3519
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3519
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3520
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3520
aagcagagtt acaatttgag aact                                              24


<210> 3521
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3521
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggccaccata accgcggaca cgtccgccaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagacgga      300

tacgcgagat actactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3522
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3522
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3523
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3524
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3524
ttcaacatca aggactacta tatgcac                                           27


<210> 3525
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3525
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3526
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3526
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3527
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3527
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3528
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3528
gcgagagacg gatacgcgag atactacttt gactac                                 36


<210> 3529
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3529
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3530
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3530
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3531
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3531
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3532
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3532
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3533
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3533
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3534
tgggcatcta cccgggaatc c                                                 21


<210> 3535
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3535
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3536
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3536
aagcagagtt acaatttgag aact                                              24


<210> 3537
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3537
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctac      180

gacccgaagt tccagggcag agtcaccatg accgcggaca cgtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggacggt      300

tatgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3538
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3538
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3539
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3540
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3540
ttcaacatca aggactacta tatgcac                                           27


<210> 3541
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3541
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3542
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3542
tggatcgacc ctgaaaatgg taacacaatc tacgacccga agttccaggg c                51


<210> 3543
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3543
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3544
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3544
gcgagggacg gttatgctag atattacttt gactac                                 36


<210> 3545
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3545
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcagag ttacaatttg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3546
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3546
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3547
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3547
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3548
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3548
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3549
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3549
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3550
tgggcatcta cccgggaatc c                                                 21


<210> 3551
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3551
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 3552
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3552
aagcagagtt acaatttgag aact                                              24


<210> 3553
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3553
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttcgggata ccccttcagt tcctatccta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgttg acaatgagaa cacaaaatat      180

tcatggaagt tccggggcag agtcaccatt accagggaca catccgcgag cacagtttac      240

atggagctga gcagtctgat atctgaagac acggctgtgt attactgtgg gagagactgg      300

gacggggcga tccgtgtctt ggactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 3554
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3554
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Val Asp Asn Glu Asn Thr Lys Tyr Ser Trp Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Trp Asp Gly Ala Ile Arg Val Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 3555
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3555
Tyr Pro Phe Ser Ser Tyr Pro Met His 
1               5                   


<210> 3556
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3556
taccccttca gttcctatcc tatgcat                                           27


<210> 3557
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3557
Trp Ile Asn Val Asp Asn Glu Asn Thr Lys Tyr Ser Trp Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 3558
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3558
tggatcaacg ttgacaatga gaacacaaaa tattcatgga agttccgggg c                51


<210> 3559
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3559
Gly Arg Asp Trp Asp Gly Ala Ile Arg Val Leu Asp Tyr 
1               5                   10              


<210> 3560
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3560
gggagagact gggacggggc gatccgtgtc ttggactac                              39


<210> 3561
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3561
gatattgtga tgactcagac tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcacctgca agtccagcca gagtgtttta ttcagctccg acaataagaa ctacttagct      120

tggtaccagc agaaaccggg acagcctcct aaattgctca tttactgggc atctatccgg      180

gaatccgggg tccctgaccg attcggtggc agcgggtctg ggacacattt cactctcacc      240

atcaccagcg tgcaggctgc agatgtggca gtttattact gtcagcaata ttatggtaat      300

ttccccacct tcggccaagg gacacgactg gagattaaa                             339


<210> 3562
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3562
Asp Ile Val Met Thr Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asp Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Gly Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Ala Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gly Asn Phe Pro Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 3563
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3563
Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asp Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3564
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3564
aagtccagcc agagtgtttt attcagctcc gacaataaga actacttagc t                51


<210> 3565
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3565
Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210> 3566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3566
tgggcatcta tccgggaatc c                                                 21


<210> 3567
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3567
Gln Gln Tyr Tyr Gly Asn Phe Pro Thr 
1               5                   


<210> 3568
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3568
cagcaatatt atggtaattt ccccacc                                           27


<210> 3569
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3569
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3570
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3570
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3571
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3571
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3572
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3572
ttcaacatca aggactacta tatgcac                                           27


<210> 3573
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3573
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3574
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3574
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3575
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3575
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3576
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3576
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3577
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3577
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattttcgg      300

agagctttcg gcggagggac caaggttgag atcaaa                                336


<210> 3578
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3578
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Phe Arg Arg Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3579
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3579
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3580
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3580
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3581
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3581
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3582
tgggcatcta cccgggaatc c                                                 21


<210> 3583
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3583
Lys Gln Ser Tyr Phe Arg Arg Ala 
1               5               


<210> 3584
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3584
aagcaatctt attttcggag agct                                              24


<210> 3585
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3585
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ccggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacaccaag gactactata tgcactgggt gcgacaggcc      120

cccgggcaaa ggcttgagtg gatgggatgg atcggccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag gtctgaagac acggcggtgt actactgcgc gagggatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3586
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3586
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Thr Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Gly Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3587
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3587
Phe Asn Thr Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3588
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3588
ttcaacacca aggactacta tatgcac                                           27


<210> 3589
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3589
Trp Ile Gly Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3590
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3590
tggatcggcc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3591
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3591
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3592
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3592
gcgagggatg gatacgctag atattacttt gactac                                 36


<210> 3593
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3593
gacatcgtaa tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca ggtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3594
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3594
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3595
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3595
Arg Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3596
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3596
aggtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3597
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3597
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3598
tgggcatcta cccgggaatc c                                                 21


<210> 3599
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3599
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3600
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3600
aagcaatctt attctcggag aact                                              24


<210> 3601
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3601
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atccgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3602
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3602
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3603
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3603
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3604
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3604
ttcaacatca aggactacta tatgcac                                           27


<210> 3605
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3605
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3606
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3606
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3607
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3607
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3608
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3608
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3609
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3609
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacggcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggactg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3610
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3610
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Thr Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3611
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3611
Lys Ser Ser Gln Ser Leu Leu Asn Gly Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3612
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3612
aagtccagcc agagtctttt aaacggcaga accagaaaga actacttagc t                51


<210> 3613
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3613
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3614
tgggcatcta cccgggaatc c                                                 21


<210> 3615
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3615
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3616
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3616
aagcaatctt attctcggag aact                                              24


<210> 3617
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3617
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaag ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3618
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3618
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3619
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3619
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3620
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3620
ttcaacatca aggactacta tatgcac                                           27


<210> 3621
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3621
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3622
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3622
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3623
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3623
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3624
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3624
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3625
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3625
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattttcgg      300

agagctttcg gcggagggac caaggttgag atcaaa                                336


<210> 3626
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3626
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Phe Arg Arg Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3627
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3627
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3628
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3628
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3629
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3629
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3630
tgggcatcta cccgggaatc c                                                 21


<210> 3631
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3631
Lys Gln Ser Tyr Phe Arg Arg Ala 
1               5               


<210> 3632
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3632
aagcaatctt attttcggag agct                                              24


<210> 3633
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3633
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3634
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3634
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3635
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3635
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3636
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3636
ttcaacatca aggactacta tatgcac                                           27


<210> 3637
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3637
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3638
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3638
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3639
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3639
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3640
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3640
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3641
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3641
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3642
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3642
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3643
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3643
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3644
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3644
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3645
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3645
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3646
tgggcatcta cccgggaatc c                                                 21


<210> 3647
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3647
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3648
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3648
aagcaatctt attctcggag aact                                              24


<210> 3649
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3649
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3650
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3650
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3651
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3651
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3652
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3652
ttcaacatca aggactacta tatgcac                                           27


<210> 3653
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3653
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3654
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3654
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3655
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3655
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3656
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3656
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3657
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3657
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcgg gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 3658
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3658
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3659
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3659
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3660
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3660
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3661
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3661
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3662
tgggcatcta cccgggaatc c                                                 21


<210> 3663
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3663
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3664
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3664
aagcaatctt attctcggag aact                                              24


<210> 3665
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3665
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ccggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacaccaag gactactata tgcactgggt gcgacaggcc      120

cccgggcaaa ggcttgagtg gatgggatgg atcggccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag gtctgaagac acggcggtgt actactgcgc gagggatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3666
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3666
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Thr Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Gly Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3667
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3667
Phe Asn Thr Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3668
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3668
ttcaacacca aggactacta tatgcac                                           27


<210> 3669
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3669
Trp Ile Gly Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3670
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3670
tggatcggcc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3671
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3671
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3672
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3672
gcgagggatg gatacgctag atattacttt gactac                                 36


<210> 3673
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3673
gacatcgtga tgacccagtc tccagactcc ctggctgtgc ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagcctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3674
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3674
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Pro Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3675
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3675
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3676
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3676
aagtccagcc agagcctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3677
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3677
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3678
tgggcatcta cccgggaatc c                                                 21


<210> 3679
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3679
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3680
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3680
aagcaatctt attctcggag aact                                              24


<210> 3681
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3681
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3682
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3682
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3683
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3683
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3684
ttcaacatca aggactacta tatgcac                                           27


<210> 3685
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3685
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3686
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3686
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3687
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3687
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3688
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3688
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3689
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3689
gacatcgtaa tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca ggtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctatccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3690
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3690
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3691
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3691
Arg Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3692
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3692
aggtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3693
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3693
Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210> 3694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3694
tgggcatcta tccgggaatc c                                                 21


<210> 3695
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3695
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3696
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3696
aagcaatctt attctcggag aact                                              24


<210> 3697
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3697
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3698
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3698
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3699
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3699
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3700
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3700
ttcaacatca aggactacta tatgcac                                           27


<210> 3701
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3701
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3702
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3702
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3703
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3703
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3704
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3704
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3705
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3705
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattttcgg      300

agagctttcg gcggagggac caaggttgag atcaaa                                336


<210> 3706
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3706
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Phe Arg Arg Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3707
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3707
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3708
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3708
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3709
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3709
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3710
tgggcatcta cccgggaatc c                                                 21


<210> 3711
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3711
Lys Gln Ser Tyr Phe Arg Arg Ala 
1               5               


<210> 3712
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3712
aagcaatctt attttcggag agct                                              24


<210> 3713
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3713
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3714
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3714
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3715
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3715
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3716
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3716
ttcaacatca aggactacta tatgcac                                           27


<210> 3717
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3717
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3718
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3718
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3719
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3719
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3720
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3720
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3721
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3721
gacatcgtaa tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca ggtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3722
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3722
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3723
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3723
Arg Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3724
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3724
aggtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3725
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3725
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3726
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3726
tgggcatcta cccgggaatc c                                                 21


<210> 3727
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3727
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3728
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3728
aagcaatctt attctcggag aact                                              24


<210> 3729
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3729
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3730
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3730
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3731
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3731
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3732
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3732
ttcaacatca aggactacta tatgcac                                           27


<210> 3733
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3733
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3734
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3734
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3735
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3735
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3736
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3736
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3737
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3737
ggcatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 3738
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3738
Gly Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3739
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3739
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3740
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3740
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3741
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3741
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3742
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3742
tgggcatcta cccgggaatc c                                                 21


<210> 3743
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3743
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3744
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3744
aagcaatctt attctcggag aact                                              24


<210> 3745
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3745
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3746
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3746
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3747
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3747
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3748
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3748
ttcaacatca aggactacta tatgcac                                           27


<210> 3749
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3749
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3750
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3750
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3751
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3751
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3752
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3752
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3753
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3753
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacggcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3754
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3754
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3755
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3755
Lys Ser Ser Gln Ser Leu Leu Asn Gly Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3756
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3756
aagtccagcc agagtctttt aaacggcaga accagaaaga actacttagc t                51


<210> 3757
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3757
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3758
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3758
tgggcatcta cccgggaatc c                                                 21


<210> 3759
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3759
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3760
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3760
aagcaatctt attctcggag aact                                              24


<210> 3761
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3761
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg acaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3762
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3762
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Asp Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3763
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3763
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3764
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3764
ttcaacatca aggactacta tatgcac                                           27


<210> 3765
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3765
Trp Ile Asp Leu Asp Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3766
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3766
tggatcgacc ttgacaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3767
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3767
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3768
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3768
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3769
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3769
gacatcgtga tgacccagtc tccagactcc ctggctgtgc ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagcctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3770
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3770
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Pro Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3771
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3771
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3772
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3772
aagtccagcc agagcctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3773
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3773
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3774
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3774
tgggcatcta cccgggaatc c                                                 21


<210> 3775
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3775
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3776
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3776
aagcaatctt attctcggag aact                                              24


<210> 3777
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3777
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atccgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3778
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3778
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3779
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3779
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3780
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3780
ttcaacatca aggactacta tatgcac                                           27


<210> 3781
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3781
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3782
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3782
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3783
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3783
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3784
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3784
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3785
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3785
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacggcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggactg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3786
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3786
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Gly 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Thr Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3787
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3787
Lys Ser Ser Gln Ser Leu Leu Asn Gly Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3788
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3788
aagtccagcc agagtctttt aaacggcaga accagaaaga actacttagc t                51


<210> 3789
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3789
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3790
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3790
tgggcatcta cccgggaatc c                                                 21


<210> 3791
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3791
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3792
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3792
aagcaatctt attctcggag aact                                              24


<210> 3793
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3793
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accaggaaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ttcctca         357


<210> 3794
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3794
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asn Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3795
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3795
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3796
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3796
ttcaacatca aggactacta tatgcac                                           27


<210> 3797
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3797
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3798
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3798
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3799
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3799
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3800
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3800
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3801
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3801
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3802
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3802
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3803
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3803
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3804
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3804
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3805
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3805
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3806
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3806
tgggcatcta cccgggaatc c                                                 21


<210> 3807
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3807
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3808
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3808
aagcaatctt attctcggag aact                                              24


<210> 3809
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3809
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3810
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3810
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3811
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3811
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3812
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3812
ttcaacatca aggactacta tatgcac                                           27


<210> 3813
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3813
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3814
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3814
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3815
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3815
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3816
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3816
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3817
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3817
gacatcgtga tgacccagtc tccagactcc ctggctgtgc ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagcctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3818
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3818
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Pro Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3819
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3819
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3820
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3820
aagtccagcc agagcctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3821
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3821
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3822
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3822
tgggcatcta cccgggaatc c                                                 21


<210> 3823
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3823
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3824
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3824
aagcaatctt attctcggag aact                                              24


<210> 3825
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3825
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3826
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3826
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3827
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3827
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3828
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3828
ttcaacatca aggactacta tatgcac                                           27


<210> 3829
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3829
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3830
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3830
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3831
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3831
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3832
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3832
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3833
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3833
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3834
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3834
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3835
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3835
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3836
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3836
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3837
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3837
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3838
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3838
tgggcatcta cccgggaatc c                                                 21


<210> 3839
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3839
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3840
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3840
aagcaatctt attctcggag aact                                              24


<210> 3841
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3841
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggact caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcggctctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attacttcga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3842
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3842
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Leu Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Gly Ser Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3843
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3843
Leu Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3844
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3844
ctcaacatca aggactacta tatgcac                                           27


<210> 3845
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3845
Trp Ile Gly Ser Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3846
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3846
tggatcggct ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3847
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3847
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3848
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3848
gcgagagatg gatacgctag atattacttc gactac                                 36


<210> 3849
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3849
gacatcgtga tgacccagtc tccagactcc ctggctgtgc ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagcctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3850
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3850
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Pro Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3851
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3851
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3852
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3852
aagtccagcc agagcctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3853
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3853
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3854
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3854
tgggcatcta cccgggaatc c                                                 21


<210> 3855
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3855
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3856
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3856
aagcaatctt attctcggag aact                                              24


<210> 3857
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3857
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggact caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3858
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3858
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Leu Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3859
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3859
Leu Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3860
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3860
ctcaacatca aggactacta tatgcac                                           27


<210> 3861
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3861
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3862
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3862
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3863
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3863
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3864
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3864
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3865
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3865
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 3866
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3866
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3867
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3867
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3868
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3868
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 3869
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3869
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3870
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3870
tgggcatcta cccgggaatc c                                                 21


<210> 3871
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3871
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3872
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3872
aagcaatctt attctcggag aact                                              24


<210> 3873
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3873
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ccggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacaccaag gactactata tgcactgggt gcgacaggcc      120

cccgggcaaa ggcttgagtg gatgggatgg atcggccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag gtctgaagac acggcggtgt actactgcgc gagggatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3874
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3874
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Thr Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Gly Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3875
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3875
Phe Asn Thr Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3876
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3876
ttcaacacca aggactacta tatgcac                                           27


<210> 3877
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3877
Trp Ile Gly Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3878
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3878
tggatcggcc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3879
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3879
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3880
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3880
gcgagggatg gatacgctag atattacttt gactac                                 36


<210> 3881
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3881
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacaacagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggttgag atcaaa                                336


<210> 3882
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3882
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Asn 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3883
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3883
Lys Ser Ser Gln Ser Leu Leu Asn Asn Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3884
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3884
aagtccagcc agagtctttt aaacaacaga accagaaaga actacttagc t                51


<210> 3885
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3885
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3886
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3886
tgggcatcta cccgggaatc c                                                 21


<210> 3887
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3887
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3888
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3888
aagcaatctt attctcggag aact                                              24


<210> 3889
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3889
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaaat ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3890
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3890
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3891
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3891
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3892
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3892
ttcaacatca aggactacta tatgcac                                           27


<210> 3893
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3893
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3894
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3894
tggatcgacc ttgaaaatgg taacacaatc tatgacccga aatttcaggg c                51


<210> 3895
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3895
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3896
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3896
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3897
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3897
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattttcgg      300

agagctttcg gcggagggac caaggttgag atcaaa                                336


<210> 3898
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3898
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Phe Arg Arg Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3899
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3899
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3900
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3900
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3901
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3901
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3902
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3902
tgggcatcta cccgggaatc c                                                 21


<210> 3903
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3903
Lys Gln Ser Tyr Phe Arg Arg Ala 
1               5               


<210> 3904
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3904
aagcaatctt attttcggag agct                                              24


<210> 3905
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3905
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

gcctgcaagg cttctggatc caatatcaag gactactatg tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atcggccctg aaaatggtaa cacagtctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3906
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3906
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ala Cys Lys Ala Ser Gly Ser Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Gly Pro Glu Asn Gly Asn Thr Val Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3907
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3907
Ser Asn Ile Lys Asp Tyr Tyr Val His 
1               5                   


<210> 3908
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3908
tccaatatca aggactacta tgtgcac                                           27


<210> 3909
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3909
Trp Ile Gly Pro Glu Asn Gly Asn Thr Val Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3910
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3910
tggatcggcc ctgaaaatgg taacacagtc tatgacccga agtttcaggg c                51


<210> 3911
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3911
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3912
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3912
gcgagagatg gatacgctag atattacttt gactac                                 36


<210> 3913
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3913
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3914
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3914
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3915
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3915
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3916
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3916
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3917
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3917
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3918
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3918
tgggcatcta cccgggaatc c                                                 21


<210> 3919
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3919
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3920
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3920
aagcaatctt attctctgag aact                                              24


<210> 3921
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3921
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agccactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gtgatggtag cacaaagtac      180

aacgagaagt tcaagggcag agtcaccatg accgcggaca agtccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc tagagatggc      300

tcatattact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3922
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3922
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3923
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3923
Tyr Thr Phe Thr Ser His Tyr Ile His 
1               5                   


<210> 3924
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3924
tacaccttca ccagccacta tatacac                                           27


<210> 3925
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3925
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3926
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3926
tggatctacc ctggtgatgg tagcacaaag tacaacgaga agttcaaggg c                51


<210> 3927
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3927
Ala Arg Asp Gly Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3928
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3928
gctagagatg gctcatatta ctttgactac                                        30


<210> 3929
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3929
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3930
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3930
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3931
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3931
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3932
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3932
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3933
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3933
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3934
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3934
tgggcatcta cccgggaatc c                                                 21


<210> 3935
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3935
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3936
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3936
aagcaatctt attctctgag aact                                              24


<210> 3937
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3937
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctcctata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg gtaatgttga cacaaggtac      180

aacgagaagt tcaagggcag agtcaccata accgcggaca agtccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc gagggattac      300

ggatactact ttgactactg gggccaagga accctggtca ccgtctcctc a               351


<210> 3938
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3938
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asp Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3939
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3939
Tyr Thr Phe Thr Ser Ser Tyr Ile His 
1               5                   


<210> 3940
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3940
tacaccttca ccagctccta tatacac                                           27


<210> 3941
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3941
Trp Ile Tyr Pro Gly Asn Val Asp Thr Arg Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3942
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3942
tggatctacc ctggtaatgt tgacacaagg tacaacgaga agttcaaggg c                51


<210> 3943
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3943
Ala Arg Asp Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 3944
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3944
gcgagggatt acggatacta ctttgactac                                        30


<210> 3945
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3945
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3946
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3946
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3947
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3947
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3948
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3948
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3949
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3949
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3950
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3950
tgggcatcta cccgggaatc c                                                 21


<210> 3951
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3951
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3952
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3952
aagcaatctt attctctgag aact                                              24


<210> 3953
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3953
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accgcggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc tagagacggt      300

tacgccagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3954
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3954
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3955
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3955
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3956
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3956
ttcaacatca aggactacta tatgcac                                           27


<210> 3957
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3957
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3958
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3958
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3959
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3959
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3960
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3960
gctagagacg gttacgccag atattacttt gactac                                 36


<210> 3961
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3961
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtggag atcaaa                                336


<210> 3962
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3962
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3963
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3963
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3964
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3964
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 3965
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3965
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3966
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3966
tgggcatcta cccgggaatc c                                                 21


<210> 3967
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3967
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 3968
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3968
aagcaatctt attctctgag aact                                              24


<210> 3969
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3969
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3970
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3970
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3971
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3971
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3972
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3972
ttcaacatca aggactacta tatgcac                                           27


<210> 3973
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3973
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3974
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3974
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3975
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3975
Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 3976
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3976
gcgagagatg gatacgggag atattacttt gactac                                 36


<210> 3977
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3977
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 3978
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3978
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3979
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3979
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3980
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3980
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 3981
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3981
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3982
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3982
tgggcatcta cccgggaatc c                                                 21


<210> 3983
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3983
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 3984
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 3984
aagcaatctt attctcggag aact                                              24


<210> 3985
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 3985
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga catttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 3986
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 3986
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 3987
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 3987
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 3988
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 3988
ttcaacatca aggactacta tatgcac                                           27


<210> 3989
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 3989
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 3990
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 3990
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 3991
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 3991
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Ile 
1               5                   10          


<210> 3992
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 3992
gcgagagatg gatacgctag atattacttt gacatt                                 36


<210> 3993
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 3993
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 3994
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 3994
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 3995
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 3995
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 3996
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 3996
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 3997
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 3997
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 3998
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 3998
tgggcatcta cccgggaatc c                                                 21


<210> 3999
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 3999
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4000
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4000
aagcaatctt attctcggag aact                                              24


<210> 4001
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4001
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat attactttga cgcttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4002
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4002
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Phe Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4003
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4003
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4004
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4004
ttcaacatca aggactacta tatgcac                                           27


<210> 4005
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4005
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4006
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4006
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4007
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4007
Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Phe Asp Ala 
1               5                   10          


<210> 4008
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4008
gcgagagatg gatacgggag atattacttt gacgct                                 36


<210> 4009
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4009
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4010
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4010
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4011
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4011
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4012
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4012
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4013
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4013
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4014
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4014
tgggcatcta cccgggaatc c                                                 21


<210> 4015
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4015
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4016
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4016
aagcaatctt attctcggag aact                                              24


<210> 4017
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4017
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat atttttttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4018
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4018
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4019
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4019
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4020
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4020
ttcaacatca aggactacta tatgcac                                           27


<210> 4021
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4021
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4022
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4022
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4023
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4023
Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Tyr 
1               5                   10          


<210> 4024
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4024
gcgagagatg gatacgctag atattttttt gactac                                 36


<210> 4025
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4025
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4026
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4026
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4027
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4027
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4028
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4028
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4029
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4029
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4030
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4030
tgggcatcta cccgggaatc c                                                 21


<210> 4031
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4031
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4032
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4032
aagcaatctt attctcggag aact                                              24


<210> 4033
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4033
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4034
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4034
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4035
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4035
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4036
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4036
ttcaacatca aggactacta tatgcac                                           27


<210> 4037
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4037
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4038
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4038
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4039
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4039
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Phe Asp Tyr 
1               5                   10          


<210> 4040
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4040
gcgagagatg gatacgggag atattttttt gactac                                 36


<210> 4041
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4041
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttggct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4042
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4042
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4043
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4043
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4044
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4044
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttggc t                51


<210> 4045
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4045
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4046
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4046
tgggcatcta cccgggaatc c                                                 21


<210> 4047
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4047
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4048
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4048
aagcaatctt attctcggag aact                                              24


<210> 4049
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4049
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat attactacga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4050
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4050
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4051
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4051
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4052
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4052
ttcaacatca aggactacta tatgcac                                           27


<210> 4053
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4053
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4054
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4054
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4055
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4055
Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Tyr Asp Tyr 
1               5                   10          


<210> 4056
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4056
gcgagagatg gatacgggag atattactac gactac                                 36


<210> 4057
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4057
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4058
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4058
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4059
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4059
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4060
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4060
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4061
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4061
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4062
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4062
tgggcatcta cccgggaatc c                                                 21


<210> 4063
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4063
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4064
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4064
aagcaatctt attctcggag aact                                              24


<210> 4065
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4065
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat attactacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4066
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4066
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4067
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4067
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4068
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4068
ttcaacatca aggactacta tatgcac                                           27


<210> 4069
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4069
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4070
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4070
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4071
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4071
Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Tyr Asp Val 
1               5                   10          


<210> 4072
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4072
gcgagagatg gatacgggag atattactac gacgtg                                 36


<210> 4073
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4073
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4074
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4074
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4075
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4075
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4076
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4076
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4077
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4077
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4078
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4078
tgggcatcta cccgggaatc c                                                 21


<210> 4079
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4079
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4080
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4080
aagcaatctt attctcggag aact                                              24


<210> 4081
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4081
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4082
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4082
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4083
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4083
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4084
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4084
ttcaacatca aggactacta tatgcac                                           27


<210> 4085
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4085
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4086
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4086
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4087
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4087
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Tyr 
1               5                   10          


<210> 4088
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4088
gcgagagatg gatacgggag atatttttac gactac                                 36


<210> 4089
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4089
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4090
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4090
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4091
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4091
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4092
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4092
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4093
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4093
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4094
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4094
tgggcatcta cccgggaatc c                                                 21


<210> 4095
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4095
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4096
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4096
aagcaatctt attctcggag aact                                              24


<210> 4097
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4097
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttttga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4098
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4098
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4099
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4099
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4100
ttcaacatca aggactacta tatgcac                                           27


<210> 4101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4101
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4102
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4103
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4103
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Phe Asp Val 
1               5                   10          


<210> 4104
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4104
gcgagagatg gatacgggag atattttttt gacgtg                                 36


<210> 4105
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4105
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4106
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4106
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4107
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4107
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4108
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4108
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4109
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4110
tgggcatcta cccgggaatc c                                                 21


<210> 4111
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4111
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4112
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4112
aagcaatctt attctcggag aact                                              24


<210> 4113
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4113
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat atttttttga catatggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4114
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4114
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4115
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4116
ttcaacatca aggactacta tatgcac                                           27


<210> 4117
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4117
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4118
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4118
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4119
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4119
Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Ile 
1               5                   10          


<210> 4120
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4120
gcgagagatg gatacgctag atattttttt gacata                                 36


<210> 4121
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4121
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4122
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4122
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4123
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4123
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4124
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4124
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4125
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4126
tgggcatcta cccgggaatc c                                                 21


<210> 4127
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4127
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4128
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4128
aagcaatctt attctcggag aact                                              24


<210> 4129
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4129
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat atttttttga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4130
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4130
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4131
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4132
ttcaacatca aggactacta tatgcac                                           27


<210> 4133
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4133
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4134
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4134
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4135
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4135
Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Val 
1               5                   10          


<210> 4136
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4136
gcgagagatg gatacgctag atattttttt gacgtg                                 36


<210> 4137
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4137
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4138
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4138
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4139
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4139
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4140
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4140
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4141
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4142
tgggcatcta cccgggaatc c                                                 21


<210> 4143
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4143
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4144
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4144
aagcaatctt attctcggag aact                                              24


<210> 4145
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4145
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat atttttacga cgtctggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4146
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4146
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4147
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4148
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4148
ttcaacatca aggactacta tatgcac                                           27


<210> 4149
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4149
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4150
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4150
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4151
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4151
Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4152
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4152
gcgagagatg gatacgctag atatttttac gacgtc                                 36


<210> 4153
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4153
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4154
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4154
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4155
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4155
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4156
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4156
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4157
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4158
tgggcatcta cccgggaatc c                                                 21


<210> 4159
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4159
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4160
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4160
aagcaatctt attctcggag aact                                              24


<210> 4161
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4161
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4162
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4162
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4163
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4164
ttcaacatca aggactacta tatgcac                                           27


<210> 4165
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4165
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4166
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4166
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4167
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4167
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4168
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4168
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4169
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4169
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4170
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4170
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4171
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4171
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4172
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4172
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4173
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4174
tgggcatcta cccgggaatc c                                                 21


<210> 4175
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4175
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4176
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4176
aagcaatctt attctcggag aact                                              24


<210> 4177
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4177
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat atttttacga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4178
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4178
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4179
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4180
ttcaacatca aggactacta tatgcac                                           27


<210> 4181
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4181
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4182
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4182
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4183
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4183
Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Tyr Asp Tyr 
1               5                   10          


<210> 4184
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4184
gcgagagatg gatacgctag atatttttac gactac                                 36


<210> 4185
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4185
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4186
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4186
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4187
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4187
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4188
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4188
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4189
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4190
tgggcatcta cccgggaatc c                                                 21


<210> 4191
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4191
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4192
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4192
aagcaatctt attctcggag aact                                              24


<210> 4193
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4193
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4194
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4194
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4195
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4196
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4196
ttcaacatca aggactacta tatgcac                                           27


<210> 4197
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4197
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4198
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4198
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4199
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4199
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4200
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4200
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4201
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4201
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4202
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4202
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4203
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4203
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4204
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4204
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4205
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4206
tgggcatcta cccgggaatc c                                                 21


<210> 4207
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4207
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4208
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4208
aagcaatctt attctcggag aact                                              24


<210> 4209
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4209
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4210
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4210
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4211
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4212
ttcaacatca aggactacta tatgcac                                           27


<210> 4213
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4213
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4214
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4214
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4215
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4215
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4216
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4216
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4217
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4217
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4218
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4218
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4219
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4219
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4220
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4220
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4221
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4222
tgggcatcta cccgggaatc c                                                 21


<210> 4223
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4223
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4224
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4224
aagcaatctt attctcggag aact                                              24


<210> 4225
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4225
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accgcggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc tagagacggt      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4226
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4226
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4227
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4228
ttcaacatca aggactacta tatgcac                                           27


<210> 4229
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4229
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4230
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4230
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4231
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4231
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4232
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4232
gctagagacg gttacgggag atatttttac gacgtg                                 36


<210> 4233
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4233
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4234
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4234
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4235
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4235
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4236
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4236
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4237
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4238
tgggcatcta cccgggaatc c                                                 21


<210> 4239
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4239
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4240
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4240
aagcaatctt attctcggag aact                                              24


<210> 4241
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4241
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4242
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4242
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4243
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4244
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4244
ttcaacatca aggactacta tatgcac                                           27


<210> 4245
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4245
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4246
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4246
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4247
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4247
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4248
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4248
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4249
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4249
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4250
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4250
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4251
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4251
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4252
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4252
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4253
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4254
tgggcatcta cccgggaatc c                                                 21


<210> 4255
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4255
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 4256
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4256
aagcaatctt attctctgag aact                                              24


<210> 4257
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4257
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4258
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4258
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4259
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4260
ttcaacatca aggactacta tatgcac                                           27


<210> 4261
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4261
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4262
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4262
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4263
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4263
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4264
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4264
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4265
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4265
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4266
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4266
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4267
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4267
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4268
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4268
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4269
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4270
tgggcatcta cccgggaatc c                                                 21


<210> 4271
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4271
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 4272
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4272
aagcaatctt attctctgag aact                                              24


<210> 4273
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4273
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggcc      120

cctggacaaa ggcttgagtg gataggatgg atcgaccctg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accgcggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc tagagacggt      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4274
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4274
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4275
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4276
ttcaacatca aggactacta tatgcac                                           27


<210> 4277
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4277
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4278
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4278
tggatcgacc ctgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4279
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4279
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4280
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4280
gctagagacg gttacgggag atatttttac gacgtg                                 36


<210> 4281
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4281
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4282
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4282
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4283
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4283
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4284
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4284
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4285
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4286
tgggcatcta cccgggaatc c                                                 21


<210> 4287
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4287
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 4288
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4288
aagcaatctt attctctgag aact                                              24


<210> 4289
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4289
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4290
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4290
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4291
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4292
ttcaacatca aggactacta tatgcac                                           27


<210> 4293
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4293
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4294
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4294
tggatcgacc ttgaagaagg taacacaatc tatgacccga agtttcaggg c                51


<210> 4295
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4295
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4296
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4296
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4297
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4297
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4298
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4298
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4299
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4299
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4300
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4300
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4301
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4302
tgggcatcta cccgggaatc c                                                 21


<210> 4303
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4303
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4304
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4304
aagcaatctt attctcggag aact                                              24


<210> 4305
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4305
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4306
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4306
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4307
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4308
ttcaacatca aggactacta tatgcac                                           27


<210> 4309
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4309
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4310
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4310
tggatcgacc ttgaaaatgg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4311
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4311
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4312
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4312
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4313
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4313
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4314
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4314
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4315
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4315
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4316
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4316
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4317
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4318
tgggcatcta cccgggaatc c                                                 21


<210> 4319
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4319
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4320
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4320
aagcaatctt attctcggag aact                                              24


<210> 4321
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4321
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4322
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4322
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4323
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4324
ttcaacatca aggactacta tatgcac                                           27


<210> 4325
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4325
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4326
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4326
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4327
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4327
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4328
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4328
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4329
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4329
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4330
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4330
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4331
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4331
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4332
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4332
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4333
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4334
tgggcatcta cccgggaatc c                                                 21


<210> 4335
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4335
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4336
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4336
aagcaatctt attctcggag aact                                              24


<210> 4337
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4337
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4338
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4338
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4339
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4340
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4340
ttcaacatca aggactacta tatgcac                                           27


<210> 4341
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4341
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4342
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4342
tggatcgacc ttgaagaagg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4343
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4343
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4344
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4344
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4345
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4345
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4346
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4346
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4347
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4347
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4348
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4348
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4349
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4350
tgggcatcta cccgggaatc c                                                 21


<210> 4351
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4351
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4352
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4352
aagcaatctt attctcggag aact                                              24


<210> 4353
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4353
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4354
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4354
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4355
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4356
ttcaacatca aggactacta tatgcac                                           27


<210> 4357
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4357
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4358
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4358
tggatcgacc ttgaaaatgg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4359
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4359
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4360
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4360
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4361
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4361
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4362
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4362
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4363
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4363
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4364
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4364
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4365
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4366
tgggcatcta cccgggaatc c                                                 21


<210> 4367
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4367
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4368
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4368
aagcaatctt attctcggag aact                                              24


<210> 4369
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4369
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4370
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4370
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4371
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4372
ttcaacatca aggactacta tatgcac                                           27


<210> 4373
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4373
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4374
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4374
tggatcgacc ttgaagaagg taacacaatc tatgacccga agtttcaggg c                51


<210> 4375
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4375
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4376
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4376
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4377
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4377
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4378
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4378
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4379
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4379
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4380
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4380
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4381
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4382
tgggcatcta cccgggaatc c                                                 21


<210> 4383
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4383
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4384
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4384
aagcaatctt attctcggag aact                                              24


<210> 4385
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4385
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4386
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4386
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4387
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4388
ttcaacatca aggactacta tatgcac                                           27


<210> 4389
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4389
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4390
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4390
tggatcgacc ttgaagaagg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4391
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4391
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4392
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4392
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4393
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4393
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4394
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4394
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4395
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4395
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4396
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4396
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4397
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4398
tgggcatcta cccgggaatc c                                                 21


<210> 4399
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4399
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4400
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4400
aagcaatctt attctcggag aact                                              24


<210> 4401
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4401
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4402
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4402
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4403
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4404
ttcaacatca aggactacta tatgcac                                           27


<210> 4405
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4405
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4406
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4406
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4407
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4407
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4408
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4408
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4409
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4409
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4410
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4410
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4411
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4411
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4412
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4412
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 4413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4413
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4414
tgggcatcta cccgggaatc c                                                 21


<210> 4415
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4415
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4416
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4416
aagcaatctt attctcggag aact                                              24


<210> 4417
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4417
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4418
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4418
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4419
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4420
ttcaacatca aggactacta tatgcac                                           27


<210> 4421
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4421
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4422
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4422
tggatcgacc ttgaagaagg taacacaatc tatgacccga agtttcaggg c                51


<210> 4423
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4423
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4424
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4424
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4425
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4425
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4426
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4426
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4427
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4427
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4428
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4428
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4429
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4430
tgggcatcta cccgggaatc c                                                 21


<210> 4431
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4431
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4432
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4432
aagcaatctt attctcggag aact                                              24


<210> 4433
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4433
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4434
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4434
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4435
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4436
ttcaacatca aggactacta tatgcac                                           27


<210> 4437
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4437
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4438
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4438
tggatcgacc ttgaaaatgg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4439
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4439
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4440
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4440
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4441
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4441
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4442
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4442
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4443
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4443
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4444
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4444
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4445
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4446
tgggcatcta cccgggaatc c                                                 21


<210> 4447
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4447
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4448
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4448
aagcaatctt attctcggag aact                                              24


<210> 4449
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4449
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4450
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4450
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4451
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4452
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4452
ttcaacatca aggactacta tatgcac                                           27


<210> 4453
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4453
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4454
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4454
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4455
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4455
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4456
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4456
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4457
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4457
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4458
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4458
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4459
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4459
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4460
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4460
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4461
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4462
tgggcatcta cccgggaatc c                                                 21


<210> 4463
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4463
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4464
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4464
aagcaatctt attctcggag aact                                              24


<210> 4465
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4465
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4466
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4466
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4467
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4468
ttcaacatca aggactacta tatgcac                                           27


<210> 4469
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4469
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4470
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4470
tggatcgacc ttgaagaagg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4471
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4471
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4472
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4472
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4473
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4473
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4474
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4474
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4475
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4475
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4476
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4476
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4477
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4478
tgggcatcta cccgggaatc c                                                 21


<210> 4479
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4479
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4480
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4480
aagcaatctt attctcggag aact                                              24


<210> 4481
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4481
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4482
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4482
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4483
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4484
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4484
ttcaacatca aggactacta tatgcac                                           27


<210> 4485
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4485
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4486
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4486
tggatcgacc ttgaaaatgg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4487
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4487
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4488
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4488
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4489
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4489
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4490
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4490
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4491
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4491
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4492
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4492
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4493
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4493
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4494
tgggcatcta cccgggaatc c                                                 21


<210> 4495
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4495
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4496
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4496
aagcaatctt attctcggag aact                                              24


<210> 4497
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4497
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4498
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4498
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4499
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4499
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4500
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4500
ttcaacatca aggactacta tatgcac                                           27


<210> 4501
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4501
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4502
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4502
tggatcgacc ttgaagaagg taacacaatc tatgacccga agtttcaggg c                51


<210> 4503
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4503
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4504
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4504
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4505
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4505
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4506
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4506
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4507
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4507
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4508
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4508
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4509
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4509
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4510
tgggcatcta cccgggaatc c                                                 21


<210> 4511
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4511
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4512
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4512
aagcaatctt attctcggag aact                                              24


<210> 4513
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4513
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagaaggtaa cacaatctat      180

caaccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagaagga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4514
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4514
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4515
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4516
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4516
ttcaacatca aggactacta tatgcac                                           27


<210> 4517
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4517
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Gln Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4518
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4518
tggatcgacc ttgaagaagg taacacaatc tatcaaccga agtttcaggg c                51


<210> 4519
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4519
Ala Arg Glu Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4520
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4520
gcgagagaag gatacgggag atatttttac gacgtg                                 36


<210> 4521
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4521
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4522
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4522
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4523
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4523
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4524
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4524
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4525
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4525
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4526
tgggcatcta cccgggaatc c                                                 21


<210> 4527
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4527
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4528
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4528
aagcaatctt attctcggag aact                                              24


<210> 4529
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4529
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4530
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4530
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4531
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4531
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4532
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4532
ttcaacatca aggactacta tatgcac                                           27


<210> 4533
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4533
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4534
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4534
tggatcgacc ttgaaaatgc taacacaatc tatgacccga agtttcaggg c                51


<210> 4535
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4535
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4536
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4536
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4537
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4537
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4538
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4538
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4539
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4539
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4540
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4540
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 4541
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4541
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4542
tgggcatcta cccgggaatc c                                                 21


<210> 4543
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4543
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4544
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4544
aagcaatctt attctcggag aact                                              24


<210> 4545
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4545
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4546
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4546
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4547
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4547
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4548
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4548
ttcaacatca aggactacta tatgcac                                           27


<210> 4549
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4549
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4550
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4550
tggatcgacc ttgaaaatgg taacacaatc tatgacgcta agtttcaggg c                51


<210> 4551
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4551
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4552
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4552
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4553
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4553
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4554
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4554
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4555
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4555
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4556
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4556
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 4557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4557
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4558
tgggcatcta cccgggaatc c                                                 21


<210> 4559
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4559
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4560
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4560
aagcaatctt attctcggag aact                                              24


<210> 4561
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4561
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4562
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4562
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4563
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4563
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4564
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4564
ttcaacatca aggactacta tatgcac                                           27


<210> 4565
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4565
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4566
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4566
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4567
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4567
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4568
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4568
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4569
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4569
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4570
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4570
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4571
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4571
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4572
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4572
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 4573
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4573
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4574
tgggcatcta cccgggaatc c                                                 21


<210> 4575
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4575
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4576
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4576
aagcaatctt attctcggag aact                                              24


<210> 4577
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4577
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4578
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4578
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4579
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4579
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4580
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4580
ttcaacatca aggactacta tatgcac                                           27


<210> 4581
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4581
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4582
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4582
tggatcgacc ttgaaaatgg taacacaatc tatgacgcta agtttcaggg c                51


<210> 4583
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4583
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4584
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4584
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4585
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4585
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4586
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4586
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4587
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4587
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4588
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4588
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 4589
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4589
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4590
tgggcatcta cccgggaatc c                                                 21


<210> 4591
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4591
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4592
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4592
aagcaatctt attctcggag aact                                              24


<210> 4593
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4593
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4594
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4594
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4595
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4595
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4596
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4596
ttcaacatca aggactacta tatgcac                                           27


<210> 4597
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4597
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4598
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4598
tggatcgacc ttgaaaatgc taacacaatc tatgacccga agtttcaggg c                51


<210> 4599
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4599
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4600
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4600
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4601
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4601
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4602
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4602
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4603
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4603
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4604
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4604
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 4605
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4605
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4606
tgggcatcta cccgggaatc c                                                 21


<210> 4607
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4607
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4608
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4608
aagcaatctt attctcggag aact                                              24


<210> 4609
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4609
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cctctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4610
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4610
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4611
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4611
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4612
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4612
ttcaacatca aggactacta tatgcac                                           27


<210> 4613
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4613
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4614
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4614
tggatcgacc ttgaaaatgc taacacaatc tatgacccga agtttcaggg c                51


<210> 4615
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4615
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4616
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4616
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4617
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4617
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4618
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4618
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4619
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4619
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4620
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4620
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4621
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4621
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4622
tgggcatcta cccgggaatc c                                                 21


<210> 4623
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4623
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4624
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4624
aagcaatctt attctcggag aact                                              24


<210> 4625
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4625
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4626
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4626
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4627
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4627
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4628
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4628
ttcaacatca aggactacta tatgcac                                           27


<210> 4629
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4629
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4630
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4630
tggatcgacc ttgaaaatgg taacacaatc tatgacgcta agtttcaggg c                51


<210> 4631
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4631
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4632
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4632
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4633
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4633
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4634
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4634
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4635
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4635
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4636
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4636
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4637
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4637
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4638
tgggcatcta cccgggaatc c                                                 21


<210> 4639
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4639
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4640
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4640
aagcaatctt attctcggag aact                                              24


<210> 4641
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4641
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4642
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4642
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4643
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4643
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4644
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4644
ttcaacatca aggactacta tatgcac                                           27


<210> 4645
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4645
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4646
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4646
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4647
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4647
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4648
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4648
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4649
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4649
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4650
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4650
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4651
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4651
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4652
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4652
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4653
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4653
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4654
tgggcatcta cccgggaatc c                                                 21


<210> 4655
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4655
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4656
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4656
aagcaatctt attctcggag aact                                              24


<210> 4657
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4657
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4658
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4658
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4659
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4659
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4660
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4660
ttcaacatca aggactacta tatgcac                                           27


<210> 4661
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4661
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4662
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4662
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 4663
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4663
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4664
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4664
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4665
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4665
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4666
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4666
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4667
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4667
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4668
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4668
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4669
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4669
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4670
tgggcatcta cccgggaatc c                                                 21


<210> 4671
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4671
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4672
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4672
aagcaatctt attctcggag aact                                              24


<210> 4673
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4673
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4674
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4674
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4675
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4675
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4676
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4676
ttcaacatca aggactacta tatgcac                                           27


<210> 4677
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4677
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4678
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4678
tggatcgacc ttgaaaatgg taacacaatc tatgacgcta agtttcaggg c                51


<210> 4679
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4679
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4680
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4680
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4681
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4681
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4682
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4682
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4683
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4683
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4684
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4684
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4685
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4685
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4686
tgggcatcta cccgggaatc c                                                 21


<210> 4687
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4687
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4688
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4688
aagcaatctt attctcggag aact                                              24


<210> 4689
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4689
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4690
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4690
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4691
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4691
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4692
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4692
ttcaacatca aggactacta tatgcac                                           27


<210> 4693
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4693
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4694
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4694
tggatcgacc ttgaaaatgc taacacaatc tatgacccga agtttcaggg c                51


<210> 4695
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4695
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4696
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4696
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4697
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4697
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4698
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4698
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4699
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4699
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4700
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4700
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4701
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4701
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4702
tgggcatcta cccgggaatc c                                                 21


<210> 4703
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4703
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4704
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4704
aagcaatctt attctcggag aact                                              24


<210> 4705
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4705
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4706
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4706
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4707
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4707
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4708
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4708
ttcaacatca aggactacta tatgcac                                           27


<210> 4709
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4709
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4710
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4710
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 4711
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4711
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4712
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4712
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 4713
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4713
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4714
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4714
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4715
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4715
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4716
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4716
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4717
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4717
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4718
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4718
tgggcatcta cccgggaatc c                                                 21


<210> 4719
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4719
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4720
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4720
aagcaatctt attctcggag aact                                              24


<210> 4721
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4721
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4722
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4722
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4723
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4723
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4724
ttcaacatca aggactacta tatgcac                                           27


<210> 4725
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4725
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4726
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4726
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4727
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4727
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4728
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4728
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4729
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4729
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4730
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4730
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4731
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4731
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4732
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4732
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4733
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4733
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4734
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4734
tgggcatcta cccgggaatc c                                                 21


<210> 4735
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4735
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4736
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4736
aagcaatctt attctcggag aact                                              24


<210> 4737
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4737
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4738
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4738
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4739
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4739
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4740
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4740
ttcaacatca aggactacta tatgcac                                           27


<210> 4741
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4741
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4742
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4742
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4743
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4743
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4744
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4744
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4745
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4745
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4746
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4746
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4747
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4747
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4748
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4748
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4749
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4749
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4750
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4750
tgggcatcta cccgggaatc c                                                 21


<210> 4751
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4751
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4752
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4752
aagcaatctt attctcggag aact                                              24


<210> 4753
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4753
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4754
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4754
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4755
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4755
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4756
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4756
ttcaacatca aggactacta tatgcac                                           27


<210> 4757
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4757
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4758
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4758
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4759
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4759
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4760
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4760
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4761
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4761
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4762
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4762
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4763
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4763
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4764
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4764
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4765
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4765
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4766
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4766
tgggcatcta cccgggaatc c                                                 21


<210> 4767
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4767
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4768
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4768
aagcaatctt attctcggag aact                                              24


<210> 4769
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4769
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4770
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4770
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4771
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4772
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4772
ttcaacatca aggactacta tatgcac                                           27


<210> 4773
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4773
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4774
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4774
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4775
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4775
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4776
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4776
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4777
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4777
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4778
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4778
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4779
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4779
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4780
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4780
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4781
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4781
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4782
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4782
tgggcatcta cccgggaatc c                                                 21


<210> 4783
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4783
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4784
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4784
aagcaatctt attctcggag aact                                              24


<210> 4785
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4785
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4786
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4786
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4787
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4787
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4788
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4788
ttcaacatca aggactacta tatgcac                                           27


<210> 4789
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4789
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4790
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4790
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4791
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4791
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4792
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4792
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4793
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4793
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4794
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4794
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4795
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4795
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4796
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4796
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4797
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4798
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4798
tgggcatcta cccgggaatc c                                                 21


<210> 4799
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4799
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4800
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4800
aagcaatctt attctcggag aact                                              24


<210> 4801
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4801
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4802
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4802
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4803
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4803
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4804
ttcaacatca aggactacta tatgcac                                           27


<210> 4805
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4805
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4806
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4806
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4807
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4807
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4808
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4808
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4809
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4809
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4810
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4810
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4811
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4811
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4812
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4812
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4813
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4813
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4814
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4814
tgggcatcta cccgggaatc c                                                 21


<210> 4815
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4815
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4816
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4816
aagcaatctt attctcggag aact                                              24


<210> 4817
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4817
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4818
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4818
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4819
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4819
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4820
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4820
ttcaacatca aggactacta tatgcac                                           27


<210> 4821
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4821
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4822
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4822
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4823
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4823
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4824
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4824
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4825
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4825
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4826
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4826
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4827
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4827
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4828
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4828
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4829
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4829
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4830
tgggcatcta cccgggaatc c                                                 21


<210> 4831
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4831
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4832
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4832
aagcaatctt attctcggag aact                                              24


<210> 4833
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4833
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4834
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4834
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4835
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4835
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4836
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4836
ttcaacatca aggactacta tatgcac                                           27


<210> 4837
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4837
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4838
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4838
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4839
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4839
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4840
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4840
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4841
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4841
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4842
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4842
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4843
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4843
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4844
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4844
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4845
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4845
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4846
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4846
tgggcatcta cccgggaatc c                                                 21


<210> 4847
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4847
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4848
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4848
aagcaatctt attctcggag aact                                              24


<210> 4849
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4849
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4850
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4850
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4851
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4852
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4852
ttcaacatca aggactacta tatgcac                                           27


<210> 4853
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4853
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4854
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4854
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4855
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4855
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4856
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4856
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4857
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4857
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4858
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4858
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4859
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4859
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4860
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4860
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4861
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4861
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4862
tgggcatcta cccgggaatc c                                                 21


<210> 4863
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4863
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4864
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4864
aagcaatctt attctcggag aact                                              24


<210> 4865
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4865
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4866
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4866
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4867
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4867
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4868
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4868
ttcaacatca aggactacta tatgcac                                           27


<210> 4869
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4869
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4870
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4870
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4871
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4871
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4872
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4872
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4873
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4873
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4874
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4874
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4875
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4875
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4876
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4876
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4877
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4877
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4878
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4878
tgggcatcta cccgggaatc c                                                 21


<210> 4879
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4879
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4880
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4880
aagcaatctt attctcggag aact                                              24


<210> 4881
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4881
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4882
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4882
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4883
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4883
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4884
ttcaacatca aggactacta tatgcac                                           27


<210> 4885
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4885
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4886
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4886
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4887
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4887
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4888
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4888
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4889
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4889
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4890
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4890
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4891
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4891
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4892
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4892
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4893
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4893
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4894
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4894
tgggcatcta cccgggaatc c                                                 21


<210> 4895
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4895
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4896
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4896
aagcaatctt attctcggag aact                                              24


<210> 4897
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4897
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4898
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4898
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4899
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4899
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4900
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4900
ttcaacatca aggactacta tatgcac                                           27


<210> 4901
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4901
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4902
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4902
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4903
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4903
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4904
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4904
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4905
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4905
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4906
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4906
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4907
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4907
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4908
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4908
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4909
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4909
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4910
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4910
tgggcatcta cccgggaatc c                                                 21


<210> 4911
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4911
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4912
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4912
aagcaatctt attctcggag aact                                              24


<210> 4913
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4913
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4914
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4914
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4915
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4915
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4916
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4916
ttcaacatca aggactacta tatgcac                                           27


<210> 4917
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4917
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4918
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4918
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4919
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4919
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4920
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4920
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4921
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4921
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4922
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4922
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4923
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4923
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4924
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4924
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4925
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4925
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4926
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4926
tgggcatcta cccgggaatc c                                                 21


<210> 4927
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4927
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4928
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4928
aagcaatctt attctcggag aact                                              24


<210> 4929
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4929
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4930
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4930
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4931
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4931
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4932
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4932
ttcaacatca aggactacta tatgcac                                           27


<210> 4933
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4933
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4934
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4934
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4935
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4935
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4936
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4936
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4937
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4937
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4938
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4938
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4939
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4939
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4940
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4940
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4941
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4941
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4942
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4942
tgggcatcta cccgggaatc c                                                 21


<210> 4943
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4943
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4944
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4944
aagcaatctt attctcggag aact                                              24


<210> 4945
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4945
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcagtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4946
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4946
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4947
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4947
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4948
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4948
ttcaacatca aggactacta tatgcac                                           27


<210> 4949
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4949
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4950
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4950
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4951
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4951
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4952
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4952
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4953
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4953
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 4954
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4954
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4955
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4955
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4956
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4956
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4957
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4957
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4958
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4958
tgggcatcta cccgggaatc c                                                 21


<210> 4959
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4959
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4960
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4960
aagcaatctt attctcggag aact                                              24


<210> 4961
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4961
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4962
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4962
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4963
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4963
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4964
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4964
ttcaacatca aggactacta tatgcac                                           27


<210> 4965
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4965
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4966
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4966
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4967
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4967
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4968
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4968
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4969
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4969
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 4970
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4970
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4971
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4971
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4972
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4972
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4973
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4973
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4974
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4974
tgggcatcta cccgggaatc c                                                 21


<210> 4975
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4975
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4976
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4976
aagcaatctt attctcggag aact                                              24


<210> 4977
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4977
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4978
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4978
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4979
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4979
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4980
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4980
ttcaacatca aggactacta tatgcac                                           27


<210> 4981
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4981
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4982
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4982
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4983
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4983
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 4984
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 4984
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 4985
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 4985
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 4986
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 4986
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 4987
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 4987
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 4988
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 4988
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 4989
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 4989
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 4990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 4990
tgggcatcta cccgggaatc c                                                 21


<210> 4991
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 4991
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 4992
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 4992
aagcaatctt attctcggag aact                                              24


<210> 4993
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 4993
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 4994
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 4994
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 4995
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 4995
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 4996
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 4996
ttcaacatca aggactacta tatgcac                                           27


<210> 4997
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 4997
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 4998
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 4998
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 4999
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 4999
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5000
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5000
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5001
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5001
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5002
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5002
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5003
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5003
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5004
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5004
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5005
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5005
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5006
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5006
tgggcatcta cccgggaatc c                                                 21


<210> 5007
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5007
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5008
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5008
aagcaatctt attctcggag aact                                              24


<210> 5009
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5009
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5010
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5010
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5011
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5011
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5012
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5012
ttcaacatca aggactacta tatgcac                                           27


<210> 5013
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5013
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5014
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5014
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5015
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5015
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5016
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5016
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5017
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5017
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5018
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5018
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5019
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5019
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5020
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5020
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5021
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5021
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5022
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5022
tgggcatcta cccgggaatc c                                                 21


<210> 5023
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5023
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5024
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5024
aagcaatctt attctcggag aact                                              24


<210> 5025
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5025
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5026
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5026
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5027
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5027
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5028
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5028
ttcaacatca aggactacta tatgcac                                           27


<210> 5029
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5029
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5030
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5030
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5031
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5031
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5032
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5032
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5033
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5033
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5034
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5034
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5035
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5035
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5036
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5036
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5037
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5037
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5038
tgggcatcta cccgggaatc c                                                 21


<210> 5039
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5039
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5040
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5040
aagcaatctt attctcggag aact                                              24


<210> 5041
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5041
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgatgt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5042
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5042
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Met Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5043
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5043
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5044
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5044
ttcaacatca aggactacta tatgcac                                           27


<210> 5045
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5045
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Met Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5046
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5046
tggatcgacc ttgaaaatgg taacacaatc tatgacccga tgtttcaggg c                51


<210> 5047
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5047
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5048
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5048
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5049
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5049
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5050
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5050
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5051
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5051
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5052
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5052
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5053
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5053
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5054
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5054
tgggcatcta cccgggaatc c                                                 21


<210> 5055
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5055
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5056
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5056
aagcaatctt attctcggag aact                                              24


<210> 5057
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5057
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5058
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5058
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5059
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5059
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5060
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5060
ttcaacatca aggactacta tatgcac                                           27


<210> 5061
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5061
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5062
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5062
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5063
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5063
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5064
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5064
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5065
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5065
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5066
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5066
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5067
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5067
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5068
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5068
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5069
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5069
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5070
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5070
tgggcatcta cccgggaatc c                                                 21


<210> 5071
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5071
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5072
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5072
aagcaatctt attctcggag aact                                              24


<210> 5073
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5073
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5074
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5074
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5075
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5075
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5076
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5076
ttcaacatca aggactacta tatgcac                                           27


<210> 5077
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5077
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5078
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5078
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5079
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5079
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5080
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5080
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5081
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5081
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5082
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5082
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5083
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5083
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5084
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5084
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5085
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5085
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5086
tgggcatcta cccgggaatc c                                                 21


<210> 5087
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5087
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5088
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5088
aagcaatctt attctcggag aact                                              24


<210> 5089
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5089
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5090
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5090
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5091
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5091
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5092
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5092
ttcaacatca aggactacta tatgcac                                           27


<210> 5093
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5093
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5094
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5094
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5095
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5095
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5096
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5096
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5097
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5097
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5098
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5098
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5099
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5099
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5100
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5100
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5101
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5102
tgggcatcta cccgggaatc c                                                 21


<210> 5103
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5103
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5104
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5104
aagcaatctt attctcggag aact                                              24


<210> 5105
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5105
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5106
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5107
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5108
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5108
ttcaacatca aggactacta tatgcac                                           27


<210> 5109
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5109
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5110
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5110
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5111
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5111
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5112
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5112
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5113
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5113
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5114
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5114
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5115
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5115
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5116
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5116
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5117
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5117
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5118
tgggcatcta cccgggaatc c                                                 21


<210> 5119
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5119
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5120
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5120
aagcaatctt attctcggag aact                                              24


<210> 5121
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5121
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5122
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5122
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5123
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5123
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5124
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5124
ttcaacatca aggactacta tatgcac                                           27


<210> 5125
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5125
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5126
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5126
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5127
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5127
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5128
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5128
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5129
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5129
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5130
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5130
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5131
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5131
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5132
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5132
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5133
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5133
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5134
tgggcatcta cccgggaatc c                                                 21


<210> 5135
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5135
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5136
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5136
aagcaatctt attctcggag aact                                              24


<210> 5137
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5137
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5138
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5138
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5139
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5139
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5140
ttcaacatca aggactacta tatgcac                                           27


<210> 5141
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5141
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5142
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5142
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5143
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5143
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5144
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5144
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5145
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5145
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5146
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5146
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5147
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5147
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5148
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5148
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5149
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5149
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5150
tgggcatcta cccgggaatc c                                                 21


<210> 5151
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5151
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5152
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5152
aagcaatctt attctcggag aact                                              24


<210> 5153
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5153
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5154
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5154
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5155
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5155
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5156
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5156
ttcaacatca aggactacta tatgcac                                           27


<210> 5157
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5157
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5158
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5158
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5159
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5159
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5160
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5160
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5161
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5161
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5162
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5162
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5163
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5163
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5164
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5164
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5165
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5165
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5166
tgggcatcta cccgggaatc c                                                 21


<210> 5167
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5167
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5168
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5168
aagcaatctt attctcggag aact                                              24


<210> 5169
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5169
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggaggat gtcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5170
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5170
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gly Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5171
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5172
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5172
ttcaacatca aggactacta tatgcac                                           27


<210> 5173
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5173
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5174
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5174
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5175
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5175
Ala Arg Asp Gly Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5176
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5176
gcgagagatg gatacgggag atatttttac gacgtg                                 36


<210> 5177
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5177
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gctgtgggac caaggtcgag atcaaa                                336


<210> 5178
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5178
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5179
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5179
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5180
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5180
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5181
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5181
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5182
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5182
tgggcatcta cccgggaatc c                                                 21


<210> 5183
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5183
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5184
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5184
aagcaatctt attctcggag aact                                              24


<210> 5185
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5185
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5186
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5186
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5187
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5188
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5188
ttcaacatca aggactacta tatgcac                                           27


<210> 5189
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5189
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5190
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5190
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5191
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5191
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5192
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5192
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 5193
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5193
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5194
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5194
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5195
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5195
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5196
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5196
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5197
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5197
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5198
tgggcatcta cccgggaatc c                                                 21


<210> 5199
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5199
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5200
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5200
aagcaatctt attctcggag aact                                              24


<210> 5201
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5201
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5202
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5202
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5203
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5203
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5204
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5204
ttcaacatca aggactacta tatgcac                                           27


<210> 5205
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5205
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5206
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5206
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5207
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5207
Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5208
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5208
ggtagagatg cgtacgggag atatttttac gacgtg                                 36


<210> 5209
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5209
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5210
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5210
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5211
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5211
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5212
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5212
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5213
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5214
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5214
tgggcatcta cccgggaatc c                                                 21


<210> 5215
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5215
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5216
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5216
aagcaatctt attctcggag aact                                              24


<210> 5217
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5217
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5218
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5218
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5219
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5220
ttcaacatca aggactacta tatgcac                                           27


<210> 5221
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5221
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5222
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5222
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5223
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5223
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5224
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5224
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 5225
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5225
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5226
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5226
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5227
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5227
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5228
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5228
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5229
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5230
tgggcatcta cccgggaatc c                                                 21


<210> 5231
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5231
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5232
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5232
aagcaatctt attctcggag aact                                              24


<210> 5233
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5233
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5234
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5234
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5235
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5236
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5236
ttcaacatca aggactacta tatgcac                                           27


<210> 5237
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5237
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5238
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5238
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5239
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5239
Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5240
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5240
ggtagagatg cgtacgggag atatttttac gacgtg                                 36


<210> 5241
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5241
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5242
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5242
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5243
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5243
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5244
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5244
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5245
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5246
tgggcatcta cccgggaatc c                                                 21


<210> 5247
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5247
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5248
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5248
aagcaatctt attctcggag aact                                              24


<210> 5249
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5249
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcgt      300

tacggggctt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5250
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5250
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5251
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5252
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5252
ttcaacatca aggactacta tatgcac                                           27


<210> 5253
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5253
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5254
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5254
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5255
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5255
Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5256
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5256
gcgagagatc gttacggggc ttatttttac gacgtg                                 36


<210> 5257
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5257
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5258
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5258
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5259
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5259
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5260
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5260
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5261
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5262
tgggcatcta cccgggaatc c                                                 21


<210> 5263
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5263
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5264
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5264
aagcaatctt attctcggag aact                                              24


<210> 5265
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5265
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5266
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5266
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5267
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5268
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5268
ttcaacatca aggactacta tatgcac                                           27


<210> 5269
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5269
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5270
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5270
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5271
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5271
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5272
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5272
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 5273
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5273
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5274
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5274
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5275
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5275
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5276
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5276
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5277
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5277
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5278
tgggcatcta cccgggaatc c                                                 21


<210> 5279
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5279
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5280
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5280
aagcaatctt attctcggag aact                                              24


<210> 5281
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5281
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcag      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5282
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5282
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5283
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5283
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5284
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5284
ttcaacatca aggactacta tatgcac                                           27


<210> 5285
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5285
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5286
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5286
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5287
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5287
Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5288
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5288
gcgagagatc agtacgggag atatttttac gacgtg                                 36


<210> 5289
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5289
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5290
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5290
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5291
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5291
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5292
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5292
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5293
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5294
tgggcatcta cccgggaatc c                                                 21


<210> 5295
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5295
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5296
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5296
aagcaatctt attctcggag aact                                              24


<210> 5297
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5297
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5298
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5298
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5299
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5300
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5300
ttcaacatca aggactacta tatgcac                                           27


<210> 5301
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5301
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5302
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5302
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5303
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5303
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5304
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5304
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 5305
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5305
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5306
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5306
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5307
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5307
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5308
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5308
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5309
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5310
tgggcatcta cccgggaatc c                                                 21


<210> 5311
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5311
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5312
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5312
aagcaatctt attctcggag aact                                              24


<210> 5313
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5313
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

tacgggagat atttttacga cctttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5314
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5314
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5315
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5315
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5316
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5316
ttcaacatca aggactacta tatgcac                                           27


<210> 5317
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5317
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5318
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5318
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5319
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5319
Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu 
1               5                   10          


<210> 5320
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5320
gcgagagatg tgtacgggag atatttttac gacctt                                 36


<210> 5321
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5321
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5322
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5322
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5323
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5323
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5324
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5324
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5325
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5326
tgggcatcta cccgggaatc c                                                 21


<210> 5327
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5327
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5328
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5328
aagcaatctt attctcggag aact                                              24


<210> 5329
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5329
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgcg      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5330
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5330
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5331
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5332
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5332
ttcaacatca aggactacta tatgcac                                           27


<210> 5333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5333
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5334
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5334
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5335
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5335
Ala Arg Asp Ala Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5336
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5336
gcgagagatg cgtacggggg gtatttttac gacgtg                                 36


<210> 5337
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5337
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5338
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5338
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5339
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5339
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5340
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5340
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5341
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5341
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5342
tgggcatcta cccgggaatc c                                                 21


<210> 5343
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5343
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5344
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5344
aagcaatctt attctcggag aact                                              24


<210> 5345
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5345
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagataat      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5346
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5346
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5347
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5347
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5348
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5348
ttcaacatca aggactacta tatgcac                                           27


<210> 5349
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5349
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5350
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5350
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5351
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5351
Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5352
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5352
gcgagagata attacggggg gtatttttac gacgtg                                 36


<210> 5353
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5353
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5354
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5354
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5355
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5355
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5356
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5356
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5357
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5357
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5358
tgggcatcta cccgggaatc c                                                 21


<210> 5359
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5359
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5360
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5360
aagcaatctt attctcggag aact                                              24


<210> 5361
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5361
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5362
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5362
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5363
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5364
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5364
ttcaacatca aggactacta tatgcac                                           27


<210> 5365
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5365
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5366
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5366
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5367
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5367
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5368
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5368
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 5369
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5369
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5370
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5370
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5371
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5371
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5372
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5372
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5373
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5373
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5374
tgggcatcta cccgggaatc c                                                 21


<210> 5375
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5375
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5376
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5376
aagcaatctt attctctgag aact                                              24


<210> 5377
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5377
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5378
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5378
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5379
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5379
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5380
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5380
ttcaacatca aggactacta tatgcac                                           27


<210> 5381
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5381
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5382
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5382
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5383
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5383
Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5384
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5384
ggtagagatg cgtacgggag atatttttac gacgtg                                 36


<210> 5385
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5385
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5386
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5386
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5387
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5387
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5388
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5388
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5389
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5390
tgggcatcta cccgggaatc c                                                 21


<210> 5391
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5391
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5392
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5392
aagcaatctt attctctgag aact                                              24


<210> 5393
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5393
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5394
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5394
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5395
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5396
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5396
ttcaacatca aggactacta tatgcac                                           27


<210> 5397
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5397
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5398
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5398
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5399
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5399
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5400
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5400
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 5401
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5401
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5402
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5402
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5403
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5403
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5404
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5404
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5405
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5406
tgggcatcta cccgggaatc c                                                 21


<210> 5407
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5407
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5408
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5408
aagcaatctt attctctgag aact                                              24


<210> 5409
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5409
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggctgt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5410
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5410
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Leu Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5411
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5412
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5412
ttcaacatca aggactacta tatgcac                                           27


<210> 5413
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5413
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5414
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5414
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5415
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5415
Gly Arg Asp Ala Tyr Gly Leu Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5416
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5416
ggtagagatg cgtacgggct gtatttttac gacgtg                                 36


<210> 5417
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5417
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5418
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5418
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5419
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5419
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5420
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5420
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5421
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5421
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5422
tgggcatcta cccgggaatc c                                                 21


<210> 5423
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5423
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5424
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5424
aagcaatctt attctctgag aact                                              24


<210> 5425
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5425
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5426
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5426
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5427
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5427
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5428
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5428
ttcaacatca aggactacta tatgcac                                           27


<210> 5429
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5429
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5430
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5430
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5431
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5431
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5432
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5432
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 5433
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5433
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5434
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5434
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5435
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5435
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5436
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5436
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5437
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5437
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5438
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5438
tgggcatcta cccgggaatc c                                                 21


<210> 5439
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5439
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5440
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5440
aagcaatctt attctctgag aact                                              24


<210> 5441
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5441
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcgt      300

tacggggctt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5442
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5442
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5443
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5444
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5444
ttcaacatca aggactacta tatgcac                                           27


<210> 5445
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5445
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5446
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5446
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5447
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5447
Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5448
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5448
gcgagagatc gttacggggc ttatttttac gacgtg                                 36


<210> 5449
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5449
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5450
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5450
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5451
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5451
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5452
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5452
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5453
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5453
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5454
tgggcatcta cccgggaatc c                                                 21


<210> 5455
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5455
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5456
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5456
aagcaatctt attctctgag aact                                              24


<210> 5457
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5457
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggctgt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5458
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5458
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Leu Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5459
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5460
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5460
ttcaacatca aggactacta tatgcac                                           27


<210> 5461
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5461
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5462
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5462
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5463
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5463
Gly Arg Asp Ala Tyr Gly Leu Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5464
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5464
ggtagagatg cgtacgggct gtatttttac gacgtg                                 36


<210> 5465
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5465
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5466
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5466
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5467
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5467
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5468
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5468
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5469
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5469
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5470
tgggcatcta cccgggaatc c                                                 21


<210> 5471
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5471
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5472
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5472
aagcaatctt attctctgag aact                                              24


<210> 5473
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5473
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5474
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5474
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5475
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5476
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5476
ttcaacatca aggactacta tatgcac                                           27


<210> 5477
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5477
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5478
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5478
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5479
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5479
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5480
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5480
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 5481
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5481
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5482
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5482
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5483
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5483
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5484
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5484
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5485
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5485
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5486
tgggcatcta cccgggaatc c                                                 21


<210> 5487
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5487
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5488
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5488
aagcaatctt attctctgag aact                                              24


<210> 5489
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5489
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

tacgggagat atttttacga cctttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5490
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5490
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5491
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5492
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5492
ttcaacatca aggactacta tatgcac                                           27


<210> 5493
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5493
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5494
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5494
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5495
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5495
Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu 
1               5                   10          


<210> 5496
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5496
gcgagagatg tgtacgggag atatttttac gacctt                                 36


<210> 5497
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5497
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5498
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5498
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5499
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5499
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5500
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5500
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5501
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5501
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5502
tgggcatcta cccgggaatc c                                                 21


<210> 5503
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5503
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5504
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5504
aagcaatctt attctctgag aact                                              24


<210> 5505
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5505
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagataat      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5506
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5506
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5507
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5507
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5508
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5508
ttcaacatca aggactacta tatgcac                                           27


<210> 5509
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5509
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5510
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5510
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5511
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5511
Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5512
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5512
gcgagagata attacggggg gtatttttac gacgtg                                 36


<210> 5513
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5513
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5514
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5514
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5515
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5515
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5516
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5516
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5517
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5518
tgggcatcta cccgggaatc c                                                 21


<210> 5519
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5519
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5520
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5520
aagcaatctt attctctgag aact                                              24


<210> 5521
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5521
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5522
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5522
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5523
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5524
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5524
ttcaacatca aggactacta tatgcac                                           27


<210> 5525
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5525
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5526
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5526
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5527
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5527
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5528
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5528
gcgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 5529
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5529
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5530
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5530
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5531
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5531
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5532
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5532
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5533
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5533
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5534
tgggcatcta cccgggaatc c                                                 21


<210> 5535
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5535
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5536
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5536
aagcaatctt attctatcag aact                                              24


<210> 5537
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5537
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5538
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5538
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5539
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5540
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5540
ttcaacatca aggactacta tatgcac                                           27


<210> 5541
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5541
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5542
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5542
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5543
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5543
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5544
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5544
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 5545
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5545
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5546
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5546
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5547
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5547
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5548
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5548
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5549
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5549
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5550
tgggcatcta cccgggaatc c                                                 21


<210> 5551
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5551
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5552
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5552
aagcaatctt attctatcag aact                                              24


<210> 5553
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5553
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcag      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5554
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5554
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5555
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5555
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5556
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5556
ttcaacatca aggactacta tatgcac                                           27


<210> 5557
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5557
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5558
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5558
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5559
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5559
Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5560
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5560
gcgagagatc agtacgggag atatttttac gacgtg                                 36


<210> 5561
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5561
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5562
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5562
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5563
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5563
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5564
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5564
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5565
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5565
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5566
tgggcatcta cccgggaatc c                                                 21


<210> 5567
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5567
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5568
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5568
aagcaatctt attctatcag aact                                              24


<210> 5569
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5569
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcgt      300

tacggggctt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5570
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5570
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5571
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5571
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5572
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5572
ttcaacatca aggactacta tatgcac                                           27


<210> 5573
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5573
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5574
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5574
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5575
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5575
Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5576
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5576
gcgagagatc gttacggggc ttatttttac gacgtg                                 36


<210> 5577
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5577
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5578
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5578
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5579
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5579
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5580
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5580
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5581
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5581
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5582
tgggcatcta cccgggaatc c                                                 21


<210> 5583
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5583
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5584
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5584
aagcaatctt attctatcag aact                                              24


<210> 5585
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5585
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcag      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5586
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5586
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5587
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5587
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5588
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5588
ttcaacatca aggactacta tatgcac                                           27


<210> 5589
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5589
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5590
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5590
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5591
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5591
Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5592
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5592
gcgagagatc agtacgggag atatttttac gacgtg                                 36


<210> 5593
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5593
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5594
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5594
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5595
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5595
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5596
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5596
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5597
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5597
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5598
tgggcatcta cccgggaatc c                                                 21


<210> 5599
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5599
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5600
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5600
aagcaatctt attctatcag aact                                              24


<210> 5601
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5601
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

tacgggagat atttttacga cctttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5602
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5602
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5603
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5603
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5604
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5604
ttcaacatca aggactacta tatgcac                                           27


<210> 5605
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5605
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5606
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5606
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5607
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5607
Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu 
1               5                   10          


<210> 5608
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5608
gcgagagatg tgtacgggag atatttttac gacctt                                 36


<210> 5609
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5609
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5610
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5610
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5611
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5611
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5612
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5612
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5613
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5613
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5614
tgggcatcta cccgggaatc c                                                 21


<210> 5615
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5615
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5616
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5616
aagcaatctt attctatcag aact                                              24


<210> 5617
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5617
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgcg      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5618
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5618
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5619
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5619
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5620
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5620
ttcaacatca aggactacta tatgcac                                           27


<210> 5621
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5621
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5622
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5622
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5623
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5623
Ala Arg Asp Ala Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5624
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5624
gcgagagatg cgtacggggg gtatttttac gacgtg                                 36


<210> 5625
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5625
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5626
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5626
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5627
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5627
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5628
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5628
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5629
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5629
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5630
tgggcatcta cccgggaatc c                                                 21


<210> 5631
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5631
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5632
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5632
aagcaatctt attctatcag aact                                              24


<210> 5633
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5633
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagataat      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5634
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5634
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5635
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5635
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5636
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5636
ttcaacatca aggactacta tatgcac                                           27


<210> 5637
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5637
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5638
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5638
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5639
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5639
Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5640
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5640
gcgagagata attacggggg gtatttttac gacgtg                                 36


<210> 5641
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5641
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctatc      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5642
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5642
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5643
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5643
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5644
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5644
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 5645
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5645
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5646
tgggcatcta cccgggaatc c                                                 21


<210> 5647
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5647
Lys Gln Ser Tyr Ser Ile Arg Thr 
1               5               


<210> 5648
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5648
aagcaatctt attctatcag aact                                              24


<210> 5649
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5649
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5650
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5650
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5651
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5651
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5652
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5652
ttcaacatca aggactacta tatgcac                                           27


<210> 5653
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5653
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5654
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5654
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5655
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5655
Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5656
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5656
ggtagagatg cgtacgggag atatttttac gacgtg                                 36


<210> 5657
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5657
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5658
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5658
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5659
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5659
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5660
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5660
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 5661
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5661
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5662
tgggcatcta cccgggaatc c                                                 21


<210> 5663
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5663
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5664
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5664
aagcaatctt attctctgag aact                                              24


<210> 5665
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5665
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aagagggcaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5666
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5666
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5667
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5667
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5668
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5668
ttcaacatca aggactacta tatgcac                                           27


<210> 5669
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5669
Trp Ile Asp Leu Glu Glu Gly Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5670
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5670
tggatcgacc ttgaagaggg caacacaatc tatgacgcta agtttcaggg c                51


<210> 5671
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5671
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5672
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5672
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 5673
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5673
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5674
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5674
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5675
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5675
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5676
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5676
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 5677
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5677
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5678
tgggcatcta cccgggaatc c                                                 21


<210> 5679
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5679
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5680
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5680
aagcaatctt attctctgag aact                                              24


<210> 5681
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5681
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagataat      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5682
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5682
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5683
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5683
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5684
ttcaacatca aggactacta tatgcac                                           27


<210> 5685
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5685
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5686
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5686
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 5687
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5687
Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 5688
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5688
gcgagagata attacggggg gtatttttac gacgtg                                 36


<210> 5689
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5689
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta gaaagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctctg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5690
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5690
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Glu Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5691
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5691
Lys Ser Ser Gln Ser Leu Leu Glu Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5692
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5692
aagtccagcc agagtctttt agaaagcaga accggaaaga actacttagc t                51


<210> 5693
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5693
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5694
tgggcatcta cccgggaatc c                                                 21


<210> 5695
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5695
Lys Gln Ser Tyr Ser Leu Arg Thr 
1               5               


<210> 5696
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5696
aagcaatctt attctctgag aact                                              24


<210> 5697
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5697
gaagtgaagc tgcagcagtc tggggctgag cttgtgaggc caggggcctt agtcaagttg       60

tcctgcaaag cttctgactt caacattaaa gactactata tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtaa tactatatat      180

gacccgaagt tccagggcaa ggccagtata acagcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgg tagggatggt      300

aactactttt ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 5698
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5698
Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Asp Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Gly Asn Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 5699
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5699
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5700
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5700
ttcaacatta aagactacta tatgcac                                           27


<210> 5701
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5701
Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5702
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5702
tggattgatc ctgagaatgg taatactata tatgacccga agttccaggg c                51


<210> 5703
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5703
Gly Arg Asp Gly Asn Tyr Phe Phe Asp Tyr 
1               5                   10  


<210> 5704
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5704
ggtagggatg gtaactactt ttttgactac                                        30


<210> 5705
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5705
gacatccagc tgactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctggag tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 5706
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5706
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 5707
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5707
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5708
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5708
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 5709
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5709
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5710
tgggcatcca ctagggaatc t                                                 21


<210> 5711
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5711
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5712
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5712
aagcaatctt ataatcttcg gacg                                              24


<210> 5713
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5713
gaagtgcagc tgcagcagtc aggacctgag ctggtgaagc ctggggcttc agtgaggatc       60

tcctgcaagg cttctgacta caccttcaca agctactata ttcactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaatt tcaaggacaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcacctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatgat      300

ggttactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 5714
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5714
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 5715
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5715
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 5716
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5716
tacaccttca caagctacta tattcac                                           27


<210> 5717
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5717
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 5718
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5718
tggatttatc ctggaaatgt taatactaag tacaatgaga atttcaagga c                51


<210> 5719
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5719
Ala Arg Asp Asp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 5720
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5720
gcaagagatg atggttacta ctttgactac                                        30


<210> 5721
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5721
gacatccagc tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac aaagctggaa atcaaa                                336


<210> 5722
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5722
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 5723
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5723
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5724
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5724
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 5725
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5725
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5726
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5726
tgggcatcca ctagggaatc t                                                 21


<210> 5727
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5727
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5728
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5728
aagcaatctt ataatcttcg gacg                                              24


<210> 5729
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5729
caagtcaagc tggagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta caccttcaca aactactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg aagatggtaa tactaaatac      180

aatgagaaat tcaagggcaa gaccacactg actgcagaca aatcctccag cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcgatct atttctgtgc aaggaataac      300

ggtagtagct atgctatgga ctactggggc caaggcacca cggtcaccgt ctcctca         357


<210> 5730
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5730
Gln Val Lys Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asp Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Asn Gly Ser Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 5731
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5731
Tyr Thr Phe Thr Asn Tyr Tyr Ile His 
1               5                   


<210> 5732
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5732
tacaccttca caaactacta tatacac                                           27


<210> 5733
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5733
Trp Ile Tyr Pro Glu Asp Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 5734
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5734
tggatttatc ctgaagatgg taatactaaa tacaatgaga aattcaaggg c                51


<210> 5735
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5735
Ala Arg Asn Asn Gly Ser Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210> 5736
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5736
gcaaggaata acggtagtag ctatgctatg gactac                                 36


<210> 5737
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5737
ggcatccagc tgactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcagtc ttataatctt      300

cggacgttcg gtggagggac caagctggag ctgaaa                                336


<210> 5738
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5738
Gly Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 5739
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5739
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5740
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5740
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 5741
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5741
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5742
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5742
tgggcatcca ctagggaatc t                                                 21


<210> 5743
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5743
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5744
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5744
aagcagtctt ataatcttcg gacg                                              24


<210> 5745
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5745
caagtacagc tggagcagtc aggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaggcagagg      120

cctggtcagg gacttgagtg gattggatgg atttttcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatggt      300

aactactcct ttgcttactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 5746
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5746
Gln Val Gln Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Tyr Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 5747
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5747
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 5748
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5748
tacaccttca caagctacta tatacac                                           27


<210> 5749
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5749
Trp Ile Phe Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 5750
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5750
tggatttttc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 5751
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5751
Ala Arg Asp Gly Asn Tyr Ser Phe Ala Tyr 
1               5                   10  


<210> 5752
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5752
gcaagagatg gtaactactc ctttgcttac                                        30


<210> 5753
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5753
gacattcagc tcactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc aaaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggagggac aaagctggaa ataaaa                                336


<210> 5754
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5754
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 5755
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5755
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5756
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5756
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 5757
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5757
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5758
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5758
tgggcatcca ctagggaatc t                                                 21


<210> 5759
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5759
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5760
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5760
aagcaatctt ataatcttcg gacg                                              24


<210> 5761
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5761
caggtgaagc tggagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca acctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tgctaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatgat      300

gggtactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 5762
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5762
Gln Val Lys Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Ala Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 5763
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5763
Tyr Thr Phe Thr Thr Tyr Tyr Ile His 
1               5                   


<210> 5764
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5764
tacaccttca caacctacta tatacac                                           27


<210> 5765
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5765
Trp Ile Tyr Pro Gly Asn Val Asn Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 5766
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5766
tggatttatc ctggaaatgt taatgctaag tacaatgaga agttcaaggg c                51


<210> 5767
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5767
Ala Arg Asp Asp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 5768
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5768
gcaagagatg atgggtacta ctttgactac                                        30


<210> 5769
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5769
gacatccagc tgactcagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac aaagctggaa aataaa                                336


<210> 5770
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5770
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Asn Lys 
            100                 105                 110         


<210> 5771
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5771
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5772
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5772
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 5773
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5773
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5774
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5774
tgggcatcca ctagggaatc t                                                 21


<210> 5775
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5775
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5776
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5776
aagcaatctt ataatcttcg gacg                                              24


<210> 5777
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5777
gaggtccagc tgcaacaatc aggacctgag ctggtgaagc ctggggcctc agtgagggta       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactcagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacaacctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatggt      300

gattactact ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 5778
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5778
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 5779
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5779
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 5780
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5780
tacaccttca caagctacta tatacac                                           27


<210> 5781
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5781
Trp Ile Tyr Pro Gly Asn Val Asn Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 5782
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5782
tggatttatc ctggaaatgt taatactcag tacaatgaga agttcaaggg c                51


<210> 5783
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5783
Ala Arg Asp Gly Asp Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 5784
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5784
gcaagagatg gtgattacta ctttgactac                                        30


<210> 5785
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5785
ggcattcagc tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgacctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac aaagttggaa ataaaa                                336


<210> 5786
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5786
Gly Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 5787
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5787
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5788
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5788
aaatccagtc agagtctgct caacagtaga acccgaaaga actacttggc t                51


<210> 5789
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5789
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5790
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5790
tgggcatcca ctagggaatc t                                                 21


<210> 5791
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5791
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5792
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5792
aagcaatctt ataatcttcg gacg                                              24


<210> 5793
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5793
gaggtcaagc tgcaggagtc tggacctgag ctggtgaagc ctggggcttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagagatggt      300

gattacttct ttgactactg gggccaaggc accacggtca ccgtctcctc a               351


<210> 5794
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5794
Glu Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 5795
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5795
Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 5796
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5796
tacaccttca caagctacta tatacac                                           27


<210> 5797
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5797
Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 5798
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5798
tggatttatc ctggaaatgt taatactaag tacaatgaga agttcaaggg c                51


<210> 5799
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5799
Ala Arg Asp Gly Asp Tyr Phe Phe Asp Tyr 
1               5                   10  


<210> 5800
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5800
gcaagagatg gtgattactt ctttgactac                                        30


<210> 5801
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5801
gacatccagc tcacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccaaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac caagctgaaa atcaaa                                336


<210> 5802
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5802
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Lys Ile Lys 
            100                 105                 110         


<210> 5803
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5803
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5804
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5804
aaatccagtc agagtctgct caacagtaga acccaaaaga actacttggc t                51


<210> 5805
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5805
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5806
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5806
tgggcatcca ctagggaatc t                                                 21


<210> 5807
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5807
Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210> 5808
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5808
aagcaatctt ataatcttcg gacg                                              24


<210> 5809
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5809
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt caccttcaat aaatacgcca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgcccgt attagaagca aatataacaa ttacgccaca      180

tactacgccg actctgtgaa agacagattc accatctcaa gagatgattc aaagaacaca      240

gcgtatctgc aaatgaacaa cctgaaaacc gaggacacgg cggtgtacta ctgcgtgagg      300

cacggcaact tcgggaattc ctatatttca tactgggcct actggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 5810
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5810
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 5811
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5811
Phe Thr Phe Asn Lys Tyr Ala Met Asn 
1               5                   


<210> 5812
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5812
ttcaccttca ataaatacgc catgaac                                           27


<210> 5813
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5813
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 5814
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5814
cgtattagaa gcaaatataa caattacgcc acatactacg ccgactctgt gaaagac          57


<210> 5815
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5815
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  15      


<210> 5816
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5816
gtgaggcacg gcaacttcgg gaattcctat atttcatact gggcctac                    48


<210> 5817
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5817
cagactgtgg tgactcagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc agtggtaatt atcccaactg ggtccagcag      120

aagcctggcc aagcccccag gggactgatt ggtggtacaa aattcctggc ccccgggaca      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccct ttcgggtgtg      240

cagcctgagg atgaggctga gtattactgc gtgctctggt atagtaatcg gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 5818
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5818
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 5819
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5819
Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210> 5820
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5820
ggctccagca ctggagctgt caccagtggt aattatccca ac                          42


<210> 5821
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5821
Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210> 5822
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5822
ggtacaaaat tcctggcccc c                                                 21


<210> 5823
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5823
Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210> 5824
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5824
gtgctctggt atagtaatcg gtgggtg                                           27


<210> 5825
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5825
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt caccttcaat aaatacgcca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgcccgt attagaagca aatataacaa ttacgccaca      180

tactacgccg actctgtgaa agacagattc accatctcaa gagatgattc aaagaacaca      240

gcgtatctgc aaatgaacaa cctgaaaacc gaggacacgg cggtgtacta ctgcgtgagg      300

cacggcaact tcgggaattc ctatatttca tactgggcct actggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 5826
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5826
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 5827
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5827
Phe Thr Phe Asn Lys Tyr Ala Met Asn 
1               5                   


<210> 5828
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5828
ttcaccttca ataaatacgc catgaac                                           27


<210> 5829
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5829
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 5830
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5830
cgtattagaa gcaaatataa caattacgcc acatactacg ccgactctgt gaaagac          57


<210> 5831
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5831
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
1               5                   10                  15      


<210> 5832
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5832
gtgaggcacg gcaacttcgg gaattcctat atttcatact gggcctac                    48


<210> 5833
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5833
cagactgtgg tgactcagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc agtggtaatt atcccaactg ggtccagcag      120

aagcctggcc aagcccccag gggactgatt ggtggtacaa aattcctggc ccccgggaca      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccct ttcgggtgtg      240

cagcctgagg atgaggctga gtattactgc gtgctctggt atagtaatcg gtgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 5834
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5834
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 5835
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5835
Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
1               5                   10                  


<210> 5836
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5836
ggctccagca ctggagctgt caccagtggt aattatccca ac                          42


<210> 5837
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5837
Gly Thr Lys Phe Leu Ala Pro 
1               5           


<210> 5838
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5838
ggtacaaaat tcctggcccc c                                                 21


<210> 5839
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5839
Val Leu Trp Tyr Ser Asn Arg Trp Val 
1               5                   


<210> 5840
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5840
gtgctctggt atagtaatcg gtgggtg                                           27


<210> 5841
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5841
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggatt caccttcacc agctactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atctaccctg aaaatgataa cacaaagtac      180

aacgagaagt tcaaggacag agtcaccata accgcggaca cgtccacgag cacagcctac      240

ctggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagggacgga      300

tattctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5842
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5842
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5843
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5843
Phe Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   


<210> 5844
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5844
ttcaccttca ccagctacta tatacac                                           27


<210> 5845
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5845
Trp Ile Tyr Pro Glu Asn Asp Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 5846
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5846
tggatctacc ctgaaaatga taacacaaag tacaacgaga agttcaagga c                51


<210> 5847
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5847
Ala Arg Asp Gly Tyr Ser Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 5848
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5848
gccagggacg gatattctag atattacttt gactac                                 36


<210> 5849
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5849
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccagaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagtctcct aagctgctca tttactggac atctacccgg      180

aagtccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtaagcaaag cttcatcctt      300

aggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210> 5850
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5850
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5851
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5851
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5852
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5852
aagtccagcc agagtctttt aaacagcaga accagaaaga actacttagc t                51


<210> 5853
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5853
Trp Thr Ser Thr Arg Lys Ser 
1               5           


<210> 5854
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5854
tggacatcta cccggaagtc c                                                 21


<210> 5855
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5855
Lys Gln Ser Phe Ile Leu Arg Thr 
1               5               


<210> 5856
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5856
aagcaaagct tcatccttag gacg                                              24


<210> 5857
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5857
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatacca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa gtccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggcgttgt actactgcgc caaggacaat      300

tccggatacg gccactacta ctacggtatg gacgtctggg ggcaagggac cacggtcacc      360

gtcgcctca                                                              369


<210> 5858
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5858
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asn Ser Gly Tyr Gly His Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ala Ser 
        115                 120             


<210> 5859
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5859
Phe Thr Phe Asp Asp Tyr Thr Met His 
1               5                   


<210> 5860
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5860
ttcacctttg atgattatac catgcac                                           27


<210> 5861
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5861
Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 5862
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5862
ggtattagtt ggaatagtgg tagcataggc tatgcggact ctgtgaaggg c                51


<210> 5863
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5863
Ala Lys Asp Asn Ser Gly Tyr Gly His Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210> 5864
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5864
gccaaggaca attccggata cggccactac tactacggta tggacgtc                    48


<210> 5865
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5865
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcaacat tacatcaatt ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210> 5866
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5866
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Ile Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 5867
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5867
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210> 5868
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5868
agggccagtc agagtgttag cagcaactta gcc                                    33


<210> 5869
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5869
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 5870
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5870
ggtgcatcca ccagggccac t                                                 21


<210> 5871
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5871
Gln His Tyr Ile Asn Trp Pro Leu Thr 
1               5                   


<210> 5872
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5872
caacattaca tcaattggcc tctcact                                           27


<210> 5873
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5873
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcggatc cctgagactc       60

tcctgtgcag ccactggatt cacctttgat gatttcacca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggcgttgt actactgcgc caaggacaac      300

agcggatacg gctactacta ctacggtatg gacgtctggg ggcaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 5874
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5874
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Asp Asp Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asn Ser Gly Tyr Gly Tyr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 5875
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5875
Phe Thr Phe Asp Asp Phe Thr Met His 
1               5                   


<210> 5876
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5876
ttcacctttg atgatttcac catgcac                                           27


<210> 5877
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5877
Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 5878
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5878
ggtattagtt ggaatagtgg tagcataggc tatgtggact ctgtgaaggg c                51


<210> 5879
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5879
Ala Lys Asp Asn Ser Gly Tyr Gly Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210> 5880
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5880
gccaaggaca acagcggata cggctactac tactacggta tggacgtc                    48


<210> 5881
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5881
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca cagtgttagc agaaactcag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg caatttatta ctgtcaacag tataataatt ggccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210> 5882
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5882
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Val Ser Arg Asn 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 5883
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5883
Arg Ala Ser His Ser Val Ser Arg Asn Ser Ala 
1               5                   10      


<210> 5884
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5884
agggccagtc acagtgttag cagaaactca gcc                                    33


<210> 5885
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5885
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 5886
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5886
ggtgcatcca ccagggccac t                                                 21


<210> 5887
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5887
Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210> 5888
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5888
caacagtata ataattggcc gctcact                                           27


<210> 5889
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5889
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcaga agctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatg gtatactatg atggaaataa tcaatactat      180

gcagactccg tgaggggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgacgac acggcggtgt acttctgcgc tagaggtcct      300

ggctataact ggttggaccc ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 5890
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5890
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Val Tyr Tyr Asp Gly Asn Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Pro Gly Tyr Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 5891
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5891
Phe Thr Phe Arg Ser Tyr Ala Met His 
1               5                   


<210> 5892
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5892
ttcaccttca gaagctatgc catgcac                                           27


<210> 5893
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5893
Met Val Tyr Tyr Asp Gly Asn Asn Gln Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 5894
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5894
atggtatact atgatggaaa taatcaatac tatgcagact ccgtgagggg c                51


<210> 5895
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5895
Ala Arg Gly Pro Gly Tyr Asn Trp Leu Asp Pro 
1               5                   10      


<210> 5896
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5896
gctagaggtc ctggctataa ctggttggac ccc                                    33


<210> 5897
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5897
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agaaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcaacag tacaacaatt ggcctctcac tttcggcgga      300

gggaccaagg tggtgatcaa a                                                321


<210> 5898
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5898
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105         


<210> 5899
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5899
Arg Ala Ser Gln Ser Val Ser Arg Asn Leu Ala 
1               5                   10      


<210> 5900
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5900
agggccagtc agagtgttag cagaaactta gcc                                    33


<210> 5901
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5901
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 5902
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5902
ggtgcatcca ccagggccac t                                                 21


<210> 5903
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5903
Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210> 5904
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5904
caacagtaca acaattggcc tctcact                                           27


<210> 5905
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5905
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

gcctgtgtag cgtctggatt caccttcaga agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctgcagtg ggtggcaatg atatactatg atggaaagaa taaatactat      180

gcagactccg tgaggggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaacctgag agtcgaggac acggcgatgt acttctgcgc cagaggtcca      300

ggctataact ggttggaccc ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 5906
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5906
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Val Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Gly Lys Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Pro Gly Tyr Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 5907
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5907
Phe Thr Phe Arg Ser Tyr Gly Met His 
1               5                   


<210> 5908
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5908
ttcaccttca gaagctatgg catgcac                                           27


<210> 5909
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5909
Met Ile Tyr Tyr Asp Gly Lys Asn Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 5910
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5910
atgatatact atgatggaaa gaataaatac tatgcagact ccgtgagggg c                51


<210> 5911
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5911
Ala Arg Gly Pro Gly Tyr Asn Trp Leu Asp Pro 
1               5                   10      


<210> 5912
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5912
gccagaggtc caggctataa ctggttggac ccc                                    33


<210> 5913
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5913
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagaattagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tagcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagatgttg cagtttatta ctgtcagcag catcataact ggcctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210> 5914
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5914
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ser Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His His Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 5915
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5915
Arg Ala Ser Gln Arg Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210> 5916
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5916
agggccagtc agagaattag cagcaactta gcc                                    33


<210> 5917
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5917
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 5918
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5918
ggtgcatcca ccagggccac t                                                 21


<210> 5919
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5919
Gln Gln His His Asn Trp Pro Leu Thr 
1               5                   


<210> 5920
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5920
cagcagcatc ataactggcc tctcact                                           27


<210> 5921
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5921
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttatgtatcc tggtttgctt attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 5922
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5922
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 5923
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5923
Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210> 5924
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5924
ttcaccttta acacatatgc catgaat                                           27


<210> 5925
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5925
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 5926
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5926
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 5927
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5927
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210> 5928
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5928
gtcaggcacg gtaacttcgg gaacagttat gtatcctggt ttgcttat                    48


<210> 5929
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5929
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccacg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 5930
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5930
Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 5931
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5931
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 5932
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5932
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 5933
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5933
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 5934
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5934
ggcacaaaca agcgcgctcc t                                                 21


<210> 5935
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5935
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 5936
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5936
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 5937
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5937
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactttga tgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5938
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5938
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5939
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5939
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5940
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5940
ttcaacatca aggactacta tatgcac                                           27


<210> 5941
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5941
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5942
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5942
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5943
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5943
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Val 
1               5                   10          


<210> 5944
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5944
gcgagagatg gatacgctag atattacttt gatgtg                                 36


<210> 5945
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5945
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5946
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5946
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5947
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5947
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5948
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5948
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5949
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5949
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5950
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5950
tgggcatcta cccgggaatc c                                                 21


<210> 5951
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5951
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5952
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5952
aagcaatctt attctcggag aact                                              24


<210> 5953
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5953
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat attactatga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5954
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5954
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5955
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5955
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5956
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5956
ttcaacatca aggactacta tatgcac                                           27


<210> 5957
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5957
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5958
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5958
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5959
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5959
Ala Arg Asp Gly Tyr Ala Arg Tyr Tyr Tyr Asp Tyr 
1               5                   10          


<210> 5960
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5960
gcgagagatg gatacgctag atattactat gactac                                 36


<210> 5961
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5961
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5962
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5962
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5963
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5963
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5964
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5964
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5965
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5965
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5966
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5966
tgggcatcta cccgggaatc c                                                 21


<210> 5967
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5967
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5968
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5968
aagcaatctt attctcggag aact                                              24


<210> 5969
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5969
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcag tagagatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5970
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5970
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5971
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5971
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5972
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5972
ttcaacatca aggactacta tatgcac                                           27


<210> 5973
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5973
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5974
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5974
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5975
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5975
Ser Arg Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 5976
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5976
agtagagatg gatacgctag atattacttt gactac                                 36


<210> 5977
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5977
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5978
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5978
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5979
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5979
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5980
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5980
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5981
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5981
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5982
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5982
tgggcatcta cccgggaatc c                                                 21


<210> 5983
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5983
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 5984
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 5984
aagcaatctt attctcggag aact                                              24


<210> 5985
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 5985
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcaa tagagatgga      300

tacgctagat attactatga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 5986
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 5986
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Arg Asp Gly Tyr Ala Arg Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 5987
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 5987
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 5988
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 5988
ttcaacatca aggactacta tatgcac                                           27


<210> 5989
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 5989
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 5990
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 5990
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 5991
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 5991
Asn Arg Asp Gly Tyr Ala Arg Tyr Tyr Tyr Asp Tyr 
1               5                   10          


<210> 5992
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 5992
aatagagatg gatacgctag atattactat gactac                                 36


<210> 5993
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 5993
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 5994
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 5994
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 5995
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 5995
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 5996
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 5996
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 5997
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 5997
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 5998
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 5998
tgggcatcta cccgggaatc c                                                 21


<210> 5999
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 5999
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6000
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6000
aagcaatctt attctcggag aact                                              24


<210> 6001
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6001
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgga      300

tacgctagat atttttttga caattggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6002
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6002
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6003
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6003
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6004
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6004
ttcaacatca aggactacta tatgcac                                           27


<210> 6005
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6005
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6006
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6006
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 6007
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6007
Ala Arg Asp Gly Tyr Ala Arg Tyr Phe Phe Asp Asn 
1               5                   10          


<210> 6008
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6008
gcgagagatg gatacgctag atattttttt gacaat                                 36


<210> 6009
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6009
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6010
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6010
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6011
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6011
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6012
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6012
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 6013
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6013
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6014
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6014
tgggcatcta cccgggaatc c                                                 21


<210> 6015
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6015
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6016
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6016
aagcaatctt attctcggag aact                                              24


<210> 6017
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6017
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatggg      300

tacgggagat attactttga ccgttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6018
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6018
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Phe Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6019
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6019
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6020
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6020
ttcaacatca aggactacta tatgcac                                           27


<210> 6021
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6021
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6022
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6022
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 6023
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6023
Ala Arg Asp Gly Tyr Gly Arg Tyr Tyr Phe Asp Arg 
1               5                   10          


<210> 6024
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6024
gcgagagatg ggtacgggag atattacttt gaccgt                                 36


<210> 6025
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6025
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagccccct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6026
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6026
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6027
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6027
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6028
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6028
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 6029
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6029
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6030
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6030
tgggcatcta cccgggaatc c                                                 21


<210> 6031
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6031
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6032
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6032
aagcaatctt attctcggag aact                                              24


<210> 6033
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6033
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatggtaa cacaatctat      180

gacccgaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg gtcggatgga      300

tacgctagat attactttga ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6034
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6034
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ser Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6035
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6035
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6036
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6036
ttcaacatca aggactacta tatgcac                                           27


<210> 6037
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6037
Trp Ile Asp Leu Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6038
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6038
tggatcgacc ttgaaaatgg taacacaatc tatgacccga agtttcaggg c                51


<210> 6039
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6039
Gly Ser Asp Gly Tyr Ala Arg Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210> 6040
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6040
gggtcggatg gatacgctag atattacttt gactac                                 36


<210> 6041
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6041
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacagcagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6042
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6042
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6043
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6043
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6044
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6044
aagtccagcc agagtctttt aaacagcaga accggaaaga actacttagc t                51


<210> 6045
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6045
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6046
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6046
tgggcatcta cccgggaatc c                                                 21


<210> 6047
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6047
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6048
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6048
aagcaatctt attctcggag aact                                              24


<210> 6049
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6049
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgg tagagatgcg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6050
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6050
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6051
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6051
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6052
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6052
ttcaacatca aggactacta tatgcac                                           27


<210> 6053
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6053
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6054
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6054
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6055
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6055
Gly Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6056
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6056
ggtagagatg cgtacgggag atatttttac gacgtg                                 36


<210> 6057
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6057
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6058
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6058
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6059
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6059
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6060
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6060
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6061
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6061
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6062
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6062
tgggcatcta cccgggaatc c                                                 21


<210> 6063
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6063
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6064
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6064
aagcaatctt attctcggag aact                                              24


<210> 6065
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6065
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

ttggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6066
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6066
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6067
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6067
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6068
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6068
ttcaacatca aggactacta tatgcac                                           27


<210> 6069
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6069
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6070
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6070
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6071
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6071
Ala Arg Asp Val Leu Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6072
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6072
gcgagagatg tgttggggag atatttttac gacgtg                                 36


<210> 6073
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6073
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6074
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6074
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6075
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6075
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6076
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6076
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6077
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6077
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6078
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6078
tgggcatcta cccgggaatc c                                                 21


<210> 6079
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6079
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6080
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6080
aagcaatctt attctcggag aact                                              24


<210> 6081
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6081
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcag      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6082
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6082
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6083
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6083
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6084
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6084
ttcaacatca aggactacta tatgcac                                           27


<210> 6085
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6085
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6086
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6086
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6087
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6087
Ala Arg Asp Gln Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6088
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6088
gcgagagatc agtacgggag atatttttac gacgtg                                 36


<210> 6089
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6089
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6090
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6090
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6091
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6091
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6092
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6092
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6093
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6093
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6094
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6094
tgggcatcta cccgggaatc c                                                 21


<210> 6095
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6095
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6096
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6096
aagcaatctt attctcggag aact                                              24


<210> 6097
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6097
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

tacgggagat atttttacga cctttggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6098
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6098
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6099
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6099
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6100
ttcaacatca aggactacta tatgcac                                           27


<210> 6101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6101
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6102
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6103
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6103
Ala Arg Asp Val Tyr Gly Arg Tyr Phe Tyr Asp Leu 
1               5                   10          


<210> 6104
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6104
gcgagagatg tgtacgggag atatttttac gacctt                                 36


<210> 6105
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6105
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6106
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6106
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6107
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6107
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6108
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6108
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6109
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6110
tgggcatcta cccgggaatc c                                                 21


<210> 6111
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6111
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6112
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6112
aagcaatctt attctcggag aact                                              24


<210> 6113
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6113
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgcg      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6114
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6114
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6115
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6116
ttcaacatca aggactacta tatgcac                                           27


<210> 6117
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6117
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6118
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6118
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6119
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6119
Ala Arg Asp Ala Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6120
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6120
gcgagagatg cgtacggggg gtatttttac gacgtg                                 36


<210> 6121
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6121
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6122
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6122
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6123
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6123
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6124
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6124
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6125
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6126
tgggcatcta cccgggaatc c                                                 21


<210> 6127
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6127
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6128
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6128
aagcaatctt attctcggag aact                                              24


<210> 6129
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6129
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagataat      300

tacggggggt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6130
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6130
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6131
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6132
ttcaacatca aggactacta tatgcac                                           27


<210> 6133
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6133
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6134
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6134
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6135
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6135
Ala Arg Asp Asn Tyr Gly Gly Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6136
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6136
gcgagagata attacggggg gtatttttac gacgtg                                 36


<210> 6137
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6137
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6138
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6138
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6139
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6139
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6140
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6140
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6141
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6142
tgggcatcta cccgggaatc c                                                 21


<210> 6143
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6143
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6144
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6144
aagcaatctt attctcggag aact                                              24


<210> 6145
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6145
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttatgtatcc tggtttgctt attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6146
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6146
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6147
Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210> 6148
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6148
ttcaccttta acacatatgc catgaat                                           27


<210> 6149
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6149
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6150
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6150
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6151
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6151
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210> 6152
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6152
gtcaggcacg gtaacttcgg gaacagttat gtatcctggt ttgcttat                    48


<210> 6153
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6153
cagactgtgg tgacccagga gccatcgctc tcggtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcccggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6154
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6154
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6155
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6155
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6156
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6156
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6157
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6158
ggcacagaca agcgcgctcc c                                                 21


<210> 6159
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6159
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 6160
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6160
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 6161
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6161
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttatgtatcc tggtttgctt attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6162
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6162
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6163
Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210> 6164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6164
ttcaccttta acacatatgc catgaat                                           27


<210> 6165
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6165
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6166
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6166
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6167
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6167
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210> 6168
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6168
gtcaggcacg gtaacttcgg gaacagttat gtatcctggt ttgcttat                    48


<210> 6169
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6169
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaagctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6170
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6170
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6171
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6171
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6172
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6172
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6173
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 6174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6174
ggcacaaaca agcgcgctcc t                                                 21


<210> 6175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6175
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 6176
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6176
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 6177
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6177
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacag ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6178
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6178
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6179
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6180
ttcacctttg acacatatgc catgaat                                           27


<210> 6181
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6181
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6182
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6182
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6183
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6183
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6184
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6184
gtcaggcacg gtaacttcgg gaacagttac gtatcctggt ttgctcat                    48


<210> 6185
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6185
cagactgtgg tgacccagga gccatcgttc tcagtgtccc ctggagggac agtcacactc       60

acttgtagat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacaa acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagatg atgaatctga ttattactgt gcgctgtggt acagtaacct ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6186
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6186
Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6187
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6187
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6188
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6188
agatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6189
Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210> 6190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6190
ggcacaaaca agcgcgctcc t                                                 21


<210> 6191
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6191
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210> 6192
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6192
gcgctgtggt acagtaacct ttgggtg                                           27


<210> 6193
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6193
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgcg      300

tacgggagat atttttacag ggtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6194
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6194
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Arg Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6195
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6196
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6196
ttcaacatca aggactacta tatgcac                                           27


<210> 6197
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6197
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6198
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6198
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6199
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6199
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Arg Val 
1               5                   10          


<210> 6200
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6200
gcgagagatg cgtacgggag atatttttac agggtg                                 36


<210> 6201
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6201
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6202
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6202
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6203
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6203
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6204
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6204
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6205
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6206
tgggcatcta cccgggaatc c                                                 21


<210> 6207
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6207
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6208
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6208
aagcaatctt attctcggag aact                                              24


<210> 6209
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6209
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgccc gagagatgct      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6210
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6210
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6211
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6212
ttcaacatca aggactacta tatgcac                                           27


<210> 6213
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6213
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6214
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6214
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6215
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6215
Pro Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6216
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6216
ccgagagatg cttacgggag atatttttac gacgtg                                 36


<210> 6217
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6217
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6218
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6218
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6219
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6219
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6220
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6220
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6221
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6222
tgggcatcta cccgggaatc c                                                 21


<210> 6223
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6223
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6224
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6224
aagcaatctt attctcggag aact                                              24


<210> 6225
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6225
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgcg      300

tacgggagat atttttacga cgggtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6226
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6226
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Gly Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6227
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6228
ttcaacatca aggactacta tatgcac                                           27


<210> 6229
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6229
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6230
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6230
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6231
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6231
Ala Arg Asp Ala Tyr Gly Arg Tyr Phe Tyr Asp Gly 
1               5                   10          


<210> 6232
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6232
gcgagagatg cgtacgggag atatttttac gacggg                                 36


<210> 6233
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6233
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6234
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6234
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6235
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6235
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6236
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6236
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6237
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6238
tgggcatcta cccgggaatc c                                                 21


<210> 6239
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6239
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6240
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6240
aagcaatctt attctcggag aact                                              24


<210> 6241
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6241
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcgt      300

tacggggctt atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6242
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6242
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6243
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6244
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6244
ttcaacatca aggactacta tatgcac                                           27


<210> 6245
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6245
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6246
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6246
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6247
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6247
Ala Arg Asp Arg Tyr Gly Ala Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6248
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6248
gcgagagatc gttacggggc ttatttttac gacgtg                                 36


<210> 6249
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6249
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6250
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6250
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6251
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6251
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6252
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6252
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6253
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6254
tgggcatcta cccgggaatc c                                                 21


<210> 6255
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6255
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6256
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6256
aagcaatctt attctcggag aact                                              24


<210> 6257
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6257
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatcgg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6258
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6258
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6259
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6260
ttcaacatca aggactacta tatgcac                                           27


<210> 6261
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6261
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6262
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6262
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6263
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6263
Ala Arg Asp Arg Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6264
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6264
gcgagagatc ggtacgggag atatttttac gacgtg                                 36


<210> 6265
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6265
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6266
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6266
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6267
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6267
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6268
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6268
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6269
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6270
tgggcatcta cccgggaatc c                                                 21


<210> 6271
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6271
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6272
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6272
aagcaatctt attctcggag aact                                              24


<210> 6273
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6273
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagattcg      300

tacgggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6274
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6274
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6275
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6276
ttcaacatca aggactacta tatgcac                                           27


<210> 6277
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6277
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6278
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6278
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6279
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6279
Ala Arg Asp Ser Tyr Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6280
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6280
gcgagagatt cgtacgggag atatttttac gacgtg                                 36


<210> 6281
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6281
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6282
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6282
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6283
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6283
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6284
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6284
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6285
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6286
tgggcatcta cccgggaatc c                                                 21


<210> 6287
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6287
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6288
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6288
aagcaatctt attctcggag aact                                              24


<210> 6289
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6289
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

tacgggagat atctttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6290
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6290
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Tyr Gly Arg Tyr Leu Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6291
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6292
ttcaacatca aggactacta tatgcac                                           27


<210> 6293
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6293
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6294
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6294
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6295
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6295
Ala Arg Asp Val Tyr Gly Arg Tyr Leu Tyr Asp Val 
1               5                   10          


<210> 6296
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6296
gcgagagatg tgtacgggag atatctttac gacgtg                                 36


<210> 6297
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6297
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6298
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6298
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6299
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6299
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6300
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6300
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6301
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6302
tgggcatcta cccgggaatc c                                                 21


<210> 6303
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6303
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6304
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6304
aagcaatctt attctcggag aact                                              24


<210> 6305
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6305
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgc gagagatgtg      300

tacaggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6306
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6306
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Tyr Arg Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6307
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6308
ttcaacatca aggactacta tatgcac                                           27


<210> 6309
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6309
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6310
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6310
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6311
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6311
Ala Arg Asp Val Tyr Arg Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6312
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6312
gcgagagatg tgtacaggag atatttttac gacgtg                                 36


<210> 6313
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6313
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6314
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6314
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6315
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6315
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6316
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6316
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6317
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6318
tgggcatcta cccgggaatc c                                                 21


<210> 6319
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6319
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6320
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6320
aagcaatctt attctcggag aact                                              24


<210> 6321
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6321
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggatt caacatcaag gactactata tgcactgggt gcgacaggct      120

cctggacaaa ggcttgagtg gatgggatgg atcgaccttg aaaatgctaa cacaatctat      180

gacgctaagt ttcagggcag ggtcaccata accagggaca cgtccgccag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggcggtgt actactgcgt gagagatctt      300

cgggggagat atttttacga cgtgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210> 6322
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6322
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Arg Gly Arg Tyr Phe Tyr Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 6323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6323
Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   


<210> 6324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6324
ttcaacatca aggactacta tatgcac                                           27


<210> 6325
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6325
Trp Ile Asp Leu Glu Asn Ala Asn Thr Ile Tyr Asp Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 6326
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6326
tggatcgacc ttgaaaatgc taacacaatc tatgacgcta agtttcaggg c                51


<210> 6327
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6327
Val Arg Asp Leu Arg Gly Arg Tyr Phe Tyr Asp Val 
1               5                   10          


<210> 6328
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6328
gtgagagatc ttcgggggag atatttttac gacgtg                                 36


<210> 6329
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6329
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtctttta aacgctagaa ccggaaagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagactt cactctcact      240

atcagtagcc tgcaggctga agatgtggca gtttattact gtaagcaatc ttattctcgg      300

agaactttcg gcggagggac caaggtcgag atcaaa                                336


<210> 6330
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6330
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ala 
            20                  25                  30          


Arg Thr Gly Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Arg Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 6331
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6331
Lys Ser Ser Gln Ser Leu Leu Asn Ala Arg Thr Gly Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 6332
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6332
aagtccagcc agagtctttt aaacgctaga accggaaaga actacttagc t                51


<210> 6333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6333
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 6334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6334
tgggcatcta cccgggaatc c                                                 21


<210> 6335
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6335
Lys Gln Ser Tyr Ser Arg Arg Thr 
1               5               


<210> 6336
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6336
aagcaatctt attctcggag aact                                              24


<210> 6337
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6337
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcaag      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6338
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6338
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Lys 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6339
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6340
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6340
ttcacctttg acacatatgc catgaat                                           27


<210> 6341
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6341
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6342
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6342
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6343
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6343
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6344
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6344
gtcaggcacg gtaacttcgg gggtggttac gtatcctggt ttgctcat                    48


<210> 6345
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6345
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6346
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6346
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6347
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6347
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6348
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6348
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6349
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6350
ggcacagaca agcgcgctcc t                                                 21


<210> 6351
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6351
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6352
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6352
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6353
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6353
gaggtgcagc tgttggggtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaactc gtacgtttcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6354
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6354
Glu Val Gln Leu Leu Gly Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6355
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6356
ttcacctttg acacatatgc catgaat                                           27


<210> 6357
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6357
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6358
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6358
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6359
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6359
Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6360
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6360
gtcaggcacg gtaacttcgg gaactcgtac gtttcctggt ttgctcat                    48


<210> 6361
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6361
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6362
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6362
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6363
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6363
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6364
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6364
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6365
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6366
ggcacagaca agcgcgctcc t                                                 21


<210> 6367
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6367
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6368
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6368
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6369
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6369
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggtggggg ttacgtagcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6370
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6370
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ala Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6371
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6372
ttcacctttg acacatatgc catgaat                                           27


<210> 6373
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6373
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6374
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6374
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6375
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6375
Val Arg His Gly Asn Phe Gly Gly Gly Tyr Val Ala Trp Phe Ala His 
1               5                   10                  15      


<210> 6376
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6376
gtcaggcacg gtaacttcgg tgggggttac gtagcctggt ttgctcat                    48


<210> 6377
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6377
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6378
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6378
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6379
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6379
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6380
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6380
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6381
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6382
ggcacagaca agcgcgctcc t                                                 21


<210> 6383
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6383
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6384
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6384
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6385
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6385
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtttaacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tccagggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6386
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6386
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Phe Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6387
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6388
ttcacctttg acacatatgc catgaat                                           27


<210> 6389
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6389
Arg Ile Arg Ser Lys Phe Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6390
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6390
aggattagat ccaagtttaa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6391
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6391
Val Arg His Gly Asn Phe Gln Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6392
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6392
gtcaggcacg gtaacttcca gggtggttac gtatcctggt ttgctcat                    48


<210> 6393
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6393
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6394
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6394
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6395
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6395
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6396
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6396
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6397
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6398
ggcacagaca agcgcgctcc t                                                 21


<210> 6399
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6399
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6400
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6400
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6401
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6401
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaacg tggggggtgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6402
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6402
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Val Gly Gly Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6403
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6404
ttcacctttg acacatatgc catgaat                                           27


<210> 6405
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6405
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6406
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6406
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6407
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6407
Val Arg His Gly Asn Val Gly Gly Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6408
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6408
gtcaggcacg gtaacgtggg gggtggttac gtatcctggt ttgctcat                    48


<210> 6409
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6409
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6410
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6410
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6411
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6411
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6412
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6412
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6413
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6414
ggcacagaca agcgcgctcc t                                                 21


<210> 6415
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6415
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6416
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6416
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6417
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6417
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacgataact tcggggctgg ttacgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6418
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6418
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6419
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6420
ttcacctttg acacatatgc catgaat                                           27


<210> 6421
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6421
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6422
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6422
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6423
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6423
Val Arg His Asp Asn Phe Gly Ala Gly Tyr Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6424
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6424
gtcaggcacg ataacttcgg ggctggttac gtatcctggt ttgctcat                    48


<210> 6425
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6425
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6426
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6426
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6427
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6427
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6428
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6428
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6429
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6430
ggcacagaca agcgcgctcc t                                                 21


<210> 6431
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6431
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6432
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6432
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6433
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6433
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcggggttgg ttacgtatcc tggtttgctt cttggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6434
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6434
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6435
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6436
ttcacctttg acacatatgc catgaat                                           27


<210> 6437
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6437
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6438
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6438
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6439
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6439
Val Arg His Gly Asn Phe Gly Val Gly Tyr Val Ser Trp Phe Ala Ser 
1               5                   10                  15      


<210> 6440
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6440
gtcaggcacg gtaacttcgg ggttggttac gtatcctggt ttgcttct                    48


<210> 6441
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6441
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6442
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6442
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6443
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6443
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6444
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6444
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6445
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6446
ggcacagaca agcgcgctcc t                                                 21


<210> 6447
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6447
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6448
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6448
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6449
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6449
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggttggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtaact tcgggaacta tgctgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6450
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6450
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6451
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6452
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6452
ttcacctttg acacatatgc catgaat                                           27


<210> 6453
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6453
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6454
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6454
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6455
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6455
Val Arg His Gly Asn Phe Gly Asn Tyr Ala Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6456
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6456
gtcaggcacg gtaacttcgg gaactatgct gtatcctggt ttgctcat                    48


<210> 6457
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6457
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6458
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6458
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6459
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6459
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6460
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6460
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6461
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6462
ggcacagaca agcgcgctcc t                                                 21


<210> 6463
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6463
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6464
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6464
gcgctgtggt acagtaacca ttgggtg                                           27


<210> 6465
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region nucleic acid sequence

<400> 6465
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acatatgcca tgaattgggt tcgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagg attagatcca agtataacaa ttacgctaca      180

tactacgcag actccgtgaa ggatcggttc accatctcca gagacgattc caagagcacg      240

ctgtatctgc aaatggaaag cctgagagcc gaggacacgg cggtgtacta ctgcgtcagg      300

cacggtagct tcgggaacca tattgtatcc tggtttgctc attggggcca aggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 6466
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region amino acid sequence

<400> 6466
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Glu Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Ser Phe Gly Asn His Ile Val Ser Trp Phe 
            100                 105                 110         


Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 6467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 amino acid sequence

<400> 6467
Phe Thr Phe Asp Thr Tyr Ala Met Asn 
1               5                   


<210> 6468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 nucleic acid sequence

<400> 6468
ttcacctttg acacatatgc catgaat                                           27


<210> 6469
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 amino acid sequence

<400> 6469
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 6470
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 nucleic acid sequence

<400> 6470
aggattagat ccaagtataa caattacgct acatactacg cagactccgt gaaggat          57


<210> 6471
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 amino acid sequence

<400> 6471
Val Arg His Gly Ser Phe Gly Asn His Ile Val Ser Trp Phe Ala His 
1               5                   10                  15      


<210> 6472
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 nucleic acid sequence

<400> 6472
gtcaggcacg gtagcttcgg gaaccatatt gtatcctggt ttgctcat                    48


<210> 6473
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region nucleic acid sequence

<400> 6473
cagactgtgg tgacccagga gccatcgctc tcagtgtccc ctggagggac agtcacactc       60

acttgtggat caagcactgg cgcagtcact actagtaact acgccaactg ggtccagcag      120

accccaggcc aggctccgcg cggactcatc ggcggcacag acaagcgcgc tcctggggtc      180

cctgatcgct tctctggctc cctgcttggg gacaaagctg ccctcaccat cacgggggcc      240

caggcagagg atgaagctga ttattactgt gcgctgtggt acagtaacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtccta                                          327


<210> 6474
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region amino acid sequence

<400> 6474
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asp Lys Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 6475
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 amino acid sequence

<400> 6475
Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210> 6476
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 nucleic acid sequence

<400> 6476
ggatcaagca ctggcgcagt cactactagt aactacgcca ac                          42


<210> 6477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 amino acid sequence

<400> 6477
Gly Thr Asp Lys Arg Ala Pro 
1               5           


<210> 6478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 nucleic acid sequence

<400> 6478
ggcacagaca agcgcgctcc t                                                 21


<210> 6479
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 amino acid sequence

<400> 6479
Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210> 6480
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 nucleic acid sequence

<400> 6480
gcgctgtggt acagtaacca ttgggtg                                           27


