                         SEQUENCE LISTING

<110>  INVECTYS
 
<120>  Recombinant measles vaccine expressing hTERT

<130>  B2491EP

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  4018
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (59)..(3457)

<400>  1
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcg         58

atg ccg cgc gct ccc cgc tgc cga gcc gtg cgc tcc ctg ctg cgc agc        106
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser           
1               5                   10                  15                

cac tac cgc gag gtg ctg ccg ctg gcc acg ttc gtg cgg cgc ctg ggg        154
His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly           
            20                  25                  30                    

ccc cag ggc tgg cgg ctg gtg cag cgc ggg gac ccg gcg gct ttc cgc        202
Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg           
        35                  40                  45                        

gcg ctg gtg gcc cag tgc ctg gtg tgc gtg ccc tgg gac gca cgg ccg        250
Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro           
    50                  55                  60                            

ccc ccc gcc gcc ccc tcc ttc cgc cag gtg tcc tgc ctg aag gag ctg        298
Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu           
65                  70                  75                  80            

gtg gcc cga gtg ctg cag agg ctg tgc gag cgc ggc gcg aag aac gtg        346
Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val           
                85                  90                  95                

ctg gcc ttc ggc ttc gcg ctg ctg gac ggg gcc cgc ggg ggc ccc ccc        394
Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro           
            100                 105                 110                   

gag gcc ttc acc acc agc gtg cgc agc tac ctg ccc aac acg gtg acc        442
Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr           
        115                 120                 125                       

gac gca ctg cgg ggg agc ggg gcg tgg ggg ctg ctg ctg cgc cgc gtg        490
Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val           
    130                 135                 140                           

ggc gac gac gtg ctg gtt cac ctg ctg gca cgc tgc gcg ctc ttt gtg        538
Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val           
145                 150                 155                 160           

ctg gtg gct ccc agc tgc gcc tac cag gtg tgc ggg ccg ccg ctg tac        586
Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr           
                165                 170                 175               

cag ctc ggc gct gcc act cag gcc cgg ccc ccg cca cac gct agt gga        634
Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly           
            180                 185                 190                   

ccc cga agg cgt ctg gga tgc gaa cgg gcc tgg aac cat agc gtc agg        682
Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg           
        195                 200                 205                       

gag gcc ggg gtc ccc ctg ggc ctg cca gcc ccg ggt gcg agg agg cgc        730
Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg           
    210                 215                 220                           

ggg ggc agt gcc agc cga agt ctg ccg ttg ccc aag agg ccc agg cgt        778
Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg           
225                 230                 235                 240           

ggc gct gcc cct gag ccg gag cgg acg ccc gtt ggg cag ggg tcc tgg        826
Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp           
                245                 250                 255               

gcc cac ccg ggc agg acg cgt gga ccg agt gac cgt ggt ttc tgt gtg        874
Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val           
            260                 265                 270                   

gtg tca cct gcc aga ccc gcc gaa gaa gcc acc tct ttg gag ggt gcg        922
Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala           
        275                 280                 285                       

ctc tct ggc acg cgc cac tcc cac cca tcc gtg ggc cgc cag cac cac        970
Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His           
    290                 295                 300                           

gcg ggc ccc cca tcc aca tcg cgg cca cca cgt ccc tgg gac acg cct       1018
Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro           
305                 310                 315                 320           

tgt ccc ccg gtg tac gcc gag acc aag cac ttc ctc tac tcc tca ggc       1066
Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly           
                325                 330                 335               

gac aag gag cag ctg cgg ccc tcc ttc cta ctc agc tct ctg agg ccc       1114
Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro           
            340                 345                 350                   

agc ctg act ggc gct cgg agg ctc gtg gag acc atc ttt ctg ggt tcc       1162
Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser           
        355                 360                 365                       

agg ccc tgg atg cca ggg act ccc cgc agg ttg ccc cgc ctg ccc cag       1210
Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln           
    370                 375                 380                           

cgc tac tgg caa atg cgg ccc ctg ttt ctg gag ctg ctt ggg aac cac       1258
Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His           
385                 390                 395                 400           

gcg cag tgc ccc tac ggg gtg ctc ctc aag acg cac tgc ccg ctg cga       1306
Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg           
                405                 410                 415               

gct gcg gtc acc cca gca gcc ggt gtc tgt gcc cgg gag aag ccc cag       1354
Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln           
            420                 425                 430                   

ggc tct gtg gcg gcc ccc gag gag gag gac aca gac ccc cgt cgc ctg       1402
Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu           
        435                 440                 445                       

gtg cag ctg ctc cgc cag cac agc agc ccc tgg cag gtg tac ggc ttc       1450
Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe           
    450                 455                 460                           

gtg cgg gcc tgc ctg cgc cgg ctg gtg ccc cca ggc ctc tgg ggc tcc       1498
Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser           
465                 470                 475                 480           

agg cac aac gaa cgc cgc ttc ctc agg aac acc aag aag ttc atc tcc       1546
Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser           
                485                 490                 495               

ctg ggg aag cat gcc aag ctc tcg ctg cag gag ctg acg tgg aag atg       1594
Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met           
            500                 505                 510                   

agc gtg cgg gac tgc gct tgg ctg cgc agg agc cca ggg gtt ggc tgt       1642
Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys           
        515                 520                 525                       

gtt ccg gcc gca gag cac cgt ctg cgt gag gag atc ctg gcc aag ttc       1690
Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe           
    530                 535                 540                           

ctg cac tgg ctg atg agt gtg tac gtc gtc gag ctg ctc agg tct ttc       1738
Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe           
545                 550                 555                 560           

ttt tat gtc acg gag acc acg ttt caa aag aac agg ctc ttt ttc tac       1786
Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr           
                565                 570                 575               

cgg aag agt gtc tgg agc aag ttg caa agc att gga atc aga cag cac       1834
Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His           
            580                 585                 590                   

ttg aag agg gtg cag ctg cgg gag ctg tcg gaa gca gag gtc agg cag       1882
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln           
        595                 600                 605                       

cat cgg gaa gcc agg ccc gcc ctg ctg acg tcc aga ctc cgc ttc atc       1930
His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile           
    610                 615                 620                           

ccc aag cct gac ggg ctg cgg ccg att gtg aac atg gac tac gtc gtg       1978
Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val           
625                 630                 635                 640           

gga gcc aga acg ttc cgc aga gaa aag agg gcc gag cgt ctc acc tcg       2026
Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser           
                645                 650                 655               

agg gtg aag gca ctg ttc agc gtg ctc aac tac gag cgg gcg cgg cgc       2074
Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg           
            660                 665                 670                   

ccc ggc ctc ctg ggc gcc tct gtg ctg ggc ctg gac gat atc cac agg       2122
Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg           
        675                 680                 685                       

gcc tgg cgc acc ttc gtg ctg cgt gtg cgg gcc cag gac ccg ccg cct       2170
Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro           
    690                 695                 700                           

gag ctg tac ttt gtc aag gtg gat gtg acg ggc gcg tac gac acc atc       2218
Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile           
705                 710                 715                 720           

ccc cag gac agg ctc acg gag gtc atc gcc agc atc atc aaa ccc cag       2266
Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln           
                725                 730                 735               

aac acg tac tgc gtg cgt cgg tat gcc gtg gtc cag aag gcc gcc cat       2314
Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His           
            740                 745                 750                   

ggg cac gtc cgc aag gcc ttc aag agc cac gtc tct acc ttg aca gac       2362
Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp           
        755                 760                 765                       

ctc cag ccg tac atg cga cag ttc gtg gct cac ctg cag gag acc agc       2410
Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser           
    770                 775                 780                           

ccg ctg agg gat gcc gtc gtc atc gag cag agc tcc tcc ctg aat gag       2458
Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu           
785                 790                 795                 800           

gcc agc agt ggc ctc ttc gac gtc ttc cta cgc ttc atg tgc cac cac       2506
Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His           
                805                 810                 815               

gcc gtg cgc atc agg ggc aag tcc tac gtc cag tgc cag ggg atc ccg       2554
Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro           
            820                 825                 830                   

cag ggc tcc atc ctc tcc acg ctg ctc tgc agc ctg tgc tac ggc gac       2602
Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp           
        835                 840                 845                       

atg gag aac aag ctg ttt gcg ggg att cgg cgg gac ggg ctg ctc ctg       2650
Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu           
    850                 855                 860                           

cgt ttg gtg gat gat ttc ttg ttg gtg aca cct cac ctc acc cac gcg       2698
Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala           
865                 870                 875                 880           

aaa acc ttc ctc agg acc ctg gtc cga ggt gtc cct gag tat ggc tgc       2746
Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys           
                885                 890                 895               

gtg gtg aac ttg cgg aag aca gtg gtg aac ttc cct gta gaa gac gag       2794
Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu           
            900                 905                 910                   

gcc ctg ggt ggc acg gct ttt gtt cag atg ccg gcc cac ggc cta ttc       2842
Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe           
        915                 920                 925                       

ccc tgg tgc ggc ctg ctg ctg gat acc cgg acc ctg gag gtg cag agc       2890
Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser           
    930                 935                 940                           

gac tac tcc agc tat gcc cgg acc tcc atc aga gcc agt ctc acc ttc       2938
Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe           
945                 950                 955                 960           

aac cgc ggc ttc aag gct ggg agg aac atg cgt cgc aaa ctc ttt ggg       2986
Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly           
                965                 970                 975               

gtc ttg cgg ctg aag tgt cac agc ctg ttt ctg gat ttg cag gtg aac       3034
Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn           
            980                 985                 990                   

agc ctc cag acg gtg tgc acc aac  atc tac aag atc ctc  ctg ctg cag     3082
Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln         
        995                 1000                 1005                     

gcg tac  agg ttt cac gca tgt  gtg ctg cag ctc cca  ttt cat cag        3127
Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln            
    1010                 1015                 1020                        

caa gtt  tgg aag aac ccc aca  ttt ttc ctg cgc gtc  atc tct gac        3172
Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp            
    1025                 1030                 1035                        

acg gcc  tcc ctc tgc tac tcc  atc ctg aaa gcc aag  aac gca ggg        3217
Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly            
    1040                 1045                 1050                        

atg tcg  ctg ggg gcc aag ggc  gcc gcc ggc cct ctg  ccc tcc gag        3262
Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu            
    1055                 1060                 1065                        

gcc gtg  cag tgg ctg tgc cac  caa gca ttc ctg ctc  aag ctg act        3307
Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr            
    1070                 1075                 1080                        

cga cac  cgt gtc acc tac gtg  cca ctc ctg ggg tca  ctc agg aca        3352
Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr            
    1085                 1090                 1095                        

gcc cag  acg cag ctg agt cgg  aag ctc ccg ggg acg  acg ctg act        3397
Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr            
    1100                 1105                 1110                        

gcc ctg  gag gcc gca gcc aac  ccg gca ctg ccc tca  gac ttc aag        3442
Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys            
    1115                 1120                 1125                        

acc atc  ctg gac tga tggccacccg cccacagcca ggccgagagc agacaccagc      3497
Thr Ile  Leu Asp                                                          
    1130                                                                  

agccctgtca cgccgggctc tacgtcccag ggagggaggg gcggcccaca cccaggcccg     3557

caccgctggg agtctgaggc ctgagtgagt gtttggccga ggcctgcatg tccggctgaa     3617

ggctgagtgt ccggctgagg cctgagcgag tgtccagcca agggctgagt gtccagcaca     3677

cctgccgtct tcacttcccc acaggctggc gctcggctcc accccagggc cagcttttcc     3737

tcaccaggag cccggcttcc actccccaca taggaatagt ccatccccag attcgccatt     3797

gttcacccct cgccctgccc tcctttgcct tccaccccca ccatccaggt ggagaccctg     3857

agaaggaccc tgggagctct gggaatttgg agtgaccaaa ggtgtgccct gtacacaggc     3917

gaggaccctg cacctggatg ggggtccctg tgggtcaaat tggggggagg tgctgtggga     3977

gtaaaatact gaatatatga gtttttcagt tttgaaaaaa a                         4018


<210>  2
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  3
<211>  22649
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pTM-MV-TERT


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  NotI restriction site

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammer head ribozyme

<220>
<221>  misc_feature
<222>  (83)..(3445)
<223>  MV Schwarz antigenome

<220>
<221>  CDS
<222>  (190)..(1767)
<223>  N protein nucleotidique sequence

<220>
<221>  CDS
<222>  (1889)..(3412)
<223>  P protein nucleotidique sequence

<220>
<221>  misc_feature
<222>  (2911)..(2922)
<223>  Factor Xa site

<220>
<221>  misc_feature
<222>  (3477)..(3489)
<223>  Cis-acting element

<220>
<221>  CDS
<222>  (3535)..(3762)
<223>  Human ubiquitin

<220>
<221>  CDS
<222>  (3763)..(7008)
<223>  delta hTERT

<220>
<221>  CDS
<222>  (7009)..(7062)
<223>  Flu HLA-A*0201

<220>
<221>  CDS
<222>  (7063)..(7107)
<223>  V5 tag

<220>
<221>  misc_feature
<222>  (7157)..(7169)
<223>  Cis-acting element

<220>
<221>  CDS
<222>  (7202)..(8209)
<223>  M protein nucleotidique sequence

<220>
<221>  CDS
<222>  (9213)..(10874)
<223>  F protein nucleotidique sequence

<220>
<221>  misc_feature
<222>  (10041)..(19658)
<223>  MV Schwarz antigenome

<220>
<221>  CDS
<222>  (11035)..(12888)
<223>  H protein nucleotidique sequence

<220>
<221>  CDS
<222>  (12998)..(19549)
<223>  L protein nucleotidique sequence

<220>
<221>  misc_feature
<222>  (13700)..(13711)
<223>  Factor Xa site

<220>
<221>  misc_feature
<222>  (19659)..(19742)
<223>  Hepatitis delta virus (HDV) ribozyme

<220>
<221>  misc_feature
<222>  (19813)..(19859)
<223>  T7 terminator

<400>  3
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgag atg gcc aca ctt tta agg agc tta gca ttg ttc aaa aga aac      231
          Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn         
          1               5                   10                          

aag gac aaa cca ccc att aca tca gga tcc ggt gga gcc atc aga gga        279
Lys Asp Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly           
15                  20                  25                  30            

atc aaa cac att att ata gta cca atc cct gga gat tcc tca att acc        327
Ile Lys His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr           
                35                  40                  45                

act cga tcc aga ctt ctg gac cgg ttg gtg agg tta att gga aac ccg        375
Thr Arg Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro           
            50                  55                  60                    

gat gtg agc ggg ccc aaa cta aca ggg gca cta ata ggt ata tta tcc        423
Asp Val Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser           
        65                  70                  75                        

tta ttt gtg gag tct cca ggt caa ttg att cag agg atc acc gat gac        471
Leu Phe Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp           
    80                  85                  90                            

cct gac gtt agc ata agg ctg tta gag gtt gtc cag agt gac cag tca        519
Pro Asp Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser           
95                  100                 105                 110           

caa tct ggc ctt acc ttc gca tca aga ggt acc aac atg gag gat gag        567
Gln Ser Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu           
                115                 120                 125               

gcg gac caa tac ttt tca cat gat gat cca att agt agt gat caa tcc        615
Ala Asp Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser           
            130                 135                 140                   

agg ttc gga tgg ttc ggg aac aag gaa atc tca gat att gaa gtg caa        663
Arg Phe Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln           
        145                 150                 155                       

gac cct gag gga ttc aac atg att ctg ggt acc atc cta gcc caa att        711
Asp Pro Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile           
    160                 165                 170                           

tgg gtc ttg ctc gca aag gcg gtt acg gcc cca gac acg gca gct gat        759
Trp Val Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp           
175                 180                 185                 190           

tcg gag cta aga agg tgg ata aag tac acc caa caa aga agg gta gtt        807
Ser Glu Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val           
                195                 200                 205               

ggt gaa ttt aga ttg gag aga aaa tgg ttg gat gtg gtg agg aac agg        855
Gly Glu Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg           
            210                 215                 220                   

att gcc gag gac ctc tcc tta cgc cga ttc atg gtc gct cta atc ctg        903
Ile Ala Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu           
        225                 230                 235                       

gat atc aag aga aca ccc gga aac aaa ccc agg att gct gaa atg ata        951
Asp Ile Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile           
    240                 245                 250                           

tgt gac att gat aca tat atc gta gag gca gga tta gcc agt ttt atc        999
Cys Asp Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile           
255                 260                 265                 270           

ctg act att aag ttt ggg ata gaa act atg tat cct gct ctt gga ctg       1047
Leu Thr Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu           
                275                 280                 285               

cat gaa ttt gct ggt gag tta tcc aca ctt gag tcc ttg atg aac ctt       1095
His Glu Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu           
            290                 295                 300                   

tac cag caa atg ggg gaa act gca ccc tac atg gta atc ctg gag aac       1143
Tyr Gln Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn           
        305                 310                 315                       

tca att cag aac aag ttc agt gca gga tca tac cct ctg ctc tgg agc       1191
Ser Ile Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser           
    320                 325                 330                           

tat gcc atg gga gta gga gtg gaa ctt gaa aac tcc atg gga ggt ttg       1239
Tyr Ala Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu           
335                 340                 345                 350           

aac ttt ggc cga tct tac ttt gat cca gca tat ttt aga tta ggg caa       1287
Asn Phe Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln           
                355                 360                 365               

gag atg gta agg agg tca gct gga aag gtc agt tcc aca ttg gca tct       1335
Glu Met Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser           
            370                 375                 380                   

gaa ctc ggt atc act gcc gag gat gca agg ctt gtt tca gag att gca       1383
Glu Leu Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala           
        385                 390                 395                       

atg cat act act gag gac aag atc agt aga gcg gtt gga ccc aga caa       1431
Met His Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln           
    400                 405                 410                           

gcc caa gta tca ttt cta cac ggt gat caa agt gag aat gag cta ccg       1479
Ala Gln Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro           
415                 420                 425                 430           

aga ttg ggg ggc aag gaa gat agg agg gtc aaa cag agt cga gga gaa       1527
Arg Leu Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu           
                435                 440                 445               

gcc agg gag agc tac aga gaa acc ggg ccc agc aga gca agt gat gcg       1575
Ala Arg Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala           
            450                 455                 460                   

aga gct gcc cat ctt cca acc ggc aca ccc cta gac att gac act gca       1623
Arg Ala Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala           
        465                 470                 475                       

acg gag tcc agc caa gat ccg cag gac agt cga agg tca gct gac gcc       1671
Thr Glu Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala           
    480                 485                 490                           

ctg ctt agg ctg caa gcc atg gca gga atc tcg gaa gaa caa ggc tca       1719
Leu Leu Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser           
495                 500                 505                 510           

gac acg gac acc cct ata gtg tac aat gac aga aat ctt cta gac tag       1767
Asp Thr Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp               
                515                 520                 525               

gtgcgagagg ccgagggcca gaacaacatc cgcctaccat ccatcattgt tataaaaaac     1827

ttaggaacca ggtccacaca gccgccagcc catcaaccat ccactcccac gattggagcc     1887

a atg gca gaa gag cag gca cgc cat gtc aaa aac gga ctg gaa tgc atc     1936
  Met Ala Glu Glu Gln Ala Arg His Val Lys Asn Gly Leu Glu Cys Ile         
                  530                 535                 540             

cgg gct ctc aag gcc gag ccc atc ggc tca ctg gcc atc gag gaa gct       1984
Arg Ala Leu Lys Ala Glu Pro Ile Gly Ser Leu Ala Ile Glu Glu Ala           
            545                 550                 555                   

atg gca gca tgg tca gaa ata tca gac aac cca gga cag gag cga gcc       2032
Met Ala Ala Trp Ser Glu Ile Ser Asp Asn Pro Gly Gln Glu Arg Ala           
        560                 565                 570                       

acc tgc agg gaa gag aag gca ggc agt tcg ggt ctc agc aaa cca tgc       2080
Thr Cys Arg Glu Glu Lys Ala Gly Ser Ser Gly Leu Ser Lys Pro Cys           
    575                 580                 585                           

ctc tca gca att gga tca act gaa ggc ggt gca cct cgc atc cgc ggt       2128
Leu Ser Ala Ile Gly Ser Thr Glu Gly Gly Ala Pro Arg Ile Arg Gly           
590                 595                 600                 605           

cag gga cct gga gag agc gat gac gac gct gaa act ttg gga atc ccc       2176
Gln Gly Pro Gly Glu Ser Asp Asp Asp Ala Glu Thr Leu Gly Ile Pro           
                610                 615                 620               

cca aga aat ctc cag gca tca agc act ggg tta cag tgt tat tac gtt       2224
Pro Arg Asn Leu Gln Ala Ser Ser Thr Gly Leu Gln Cys Tyr Tyr Val           
            625                 630                 635                   

tat gat cac agc ggt gaa gcg gtt aag gga atc caa gat gct gac tct       2272
Tyr Asp His Ser Gly Glu Ala Val Lys Gly Ile Gln Asp Ala Asp Ser           
        640                 645                 650                       

atc atg gtt caa tca ggc ctt gat ggt gat agc acc ctc tca gga gga       2320
Ile Met Val Gln Ser Gly Leu Asp Gly Asp Ser Thr Leu Ser Gly Gly           
    655                 660                 665                           

gac aat gaa tct gaa aac agc gat gtg gat att ggc gaa cct gat acc       2368
Asp Asn Glu Ser Glu Asn Ser Asp Val Asp Ile Gly Glu Pro Asp Thr           
670                 675                 680                 685           

gag gga tat gct atc act gac cgg gga tct gct ccc atc tct atg ggg       2416
Glu Gly Tyr Ala Ile Thr Asp Arg Gly Ser Ala Pro Ile Ser Met Gly           
                690                 695                 700               

ttc agg gct tct gat gtt gaa act gca gaa gga ggg gag atc cac gag       2464
Phe Arg Ala Ser Asp Val Glu Thr Ala Glu Gly Gly Glu Ile His Glu           
            705                 710                 715                   

ctc ctg aga ctc caa tcc aga ggc aac aac ttt ccg aag ctt ggg aaa       2512
Leu Leu Arg Leu Gln Ser Arg Gly Asn Asn Phe Pro Lys Leu Gly Lys           
        720                 725                 730                       

act ctc aat gtt cct ccg ccc ccg gac ccc ggt agg gcc agc act tcc       2560
Thr Leu Asn Val Pro Pro Pro Pro Asp Pro Gly Arg Ala Ser Thr Ser           
    735                 740                 745                           

ggg aca ccc att aaa aag ggc aca gac gcg aga tta gcc tca ttt gga       2608
Gly Thr Pro Ile Lys Lys Gly Thr Asp Ala Arg Leu Ala Ser Phe Gly           
750                 755                 760                 765           

acg gag atc gcg tct tta ttg aca ggt ggt gca acc caa tgt gct cga       2656
Thr Glu Ile Ala Ser Leu Leu Thr Gly Gly Ala Thr Gln Cys Ala Arg           
                770                 775                 780               

aag tca ccc tcg gaa cca tca ggg cca ggt gca cct gcg ggg aat gtc       2704
Lys Ser Pro Ser Glu Pro Ser Gly Pro Gly Ala Pro Ala Gly Asn Val           
            785                 790                 795                   

ccc gag tgt gtg agc aat gcc gca ctg ata cag gag tgg aca ccc gaa       2752
Pro Glu Cys Val Ser Asn Ala Ala Leu Ile Gln Glu Trp Thr Pro Glu           
        800                 805                 810                       

tct ggt acc aca atc tcc ccg aga tcc cag aat aat gaa gaa ggg gga       2800
Ser Gly Thr Thr Ile Ser Pro Arg Ser Gln Asn Asn Glu Glu Gly Gly           
    815                 820                 825                           

gac tat tat gat gat gag ctg ttc tct gat gtc caa gat att aaa aca       2848
Asp Tyr Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys Thr           
830                 835                 840                 845           

gcc ttg gcc aaa ata cac gag gat aat cag aag ata atc tcc aag cta       2896
Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu           
                850                 855                 860               

gaa tca ctg ctg tta ttg aag gga gaa gtt gag tca att aag aag cag       2944
Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys Gln           
            865                 870                 875                   

atc aac agg caa aat atc agc ata tcc acc ctg gaa gga cac ctc tca       2992
Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu Ser           
        880                 885                 890                       

agc atc atg atc gcc att cct gga ctt ggg aag gat ccc aac gac ccc       3040
Ser Ile Met Ile Ala Ile Pro Gly Leu Gly Lys Asp Pro Asn Asp Pro           
    895                 900                 905                           

act gca gat gtc gaa atc aat ccc gac ttg aaa ccc atc ata ggc aga       3088
Thr Ala Asp Val Glu Ile Asn Pro Asp Leu Lys Pro Ile Ile Gly Arg           
910                 915                 920                 925           

gat tca ggc cga gca ctg gcc gaa gtt ctc aag aaa ccc gtt gcc agc       3136
Asp Ser Gly Arg Ala Leu Ala Glu Val Leu Lys Lys Pro Val Ala Ser           
                930                 935                 940               

cga caa ctc caa gga atg aca aat gga cgg acc agt tcc aga gga cag       3184
Arg Gln Leu Gln Gly Met Thr Asn Gly Arg Thr Ser Ser Arg Gly Gln           
            945                 950                 955                   

ctg ctg aag gaa ttt cag cta aag ccg atc ggg aaa aag atg agc tca       3232
Leu Leu Lys Glu Phe Gln Leu Lys Pro Ile Gly Lys Lys Met Ser Ser           
        960                 965                 970                       

gcc gtc ggg ttt gtt cct gac acc ggc cct gca tca cgc agt gta atc       3280
Ala Val Gly Phe Val Pro Asp Thr Gly Pro Ala Ser Arg Ser Val Ile           
    975                 980                 985                           

cgc tcc att ata aaa tcc agc cgg cta gag gag  gat cgg aag cgt tac      3328
Arg Ser Ile Ile Lys Ser Ser Arg Leu Glu Glu  Asp Arg Lys Arg Tyr          
990                 995                 1000                 1005         

ctg atg act ctc ctt  gat gat atc aaa gga  gcc aat gat ctt gcc         3373
Leu Met Thr Leu Leu  Asp Asp Ile Lys Gly  Ala Asn Asp Leu Ala             
                1010                 1015                 1020            

aag ttc cac cag atg  ctg atg aag ata ata  atg aag tag ctacagctca      3422
Lys Phe His Gln Met  Leu Met Lys Ile Ile  Met Lys                         
                1025                 1030                                 

acttacctgc caaccccatg ccagtcgacc caactagcct accctccatc attgttataa     3482

aaaacttagg aaccaggtcc acacagccgc cagcccatca acgcgtacga tg atg cag     3540
                                                          Met Gln         
                                                                          

att  ttc gtc aaa aca ttg  aca gga aag acc atc  aca ctg gaa gtg        3585
Ile  Phe Val Lys Thr Leu  Thr Gly Lys Thr Ile  Thr Leu Glu Val            
1035                 1040                 1045                            

gag  cca agc gac act att  gag aac gtc aaa gcc  aag att cag gac        3630
Glu  Pro Ser Asp Thr Ile  Glu Asn Val Lys Ala  Lys Ile Gln Asp            
1050                 1055                 1060                            

aag  gag ggc atc cca cca  gac cag cag agg ctg  att ttt gcc gga        3675
Lys  Glu Gly Ile Pro Pro  Asp Gln Gln Arg Leu  Ile Phe Ala Gly            
1065                 1070                 1075                            

aag  cag ctg gag gac gga  cgc aca ctc agt gac  tac aat atc cag        3720
Lys  Gln Leu Glu Asp Gly  Arg Thr Leu Ser Asp  Tyr Asn Ile Gln            
1080                 1085                 1090                            

aag  gaa agt act ctg cat  ctg gtc ctt cgc ctg  cgc ggc gga aga        3765
Lys  Glu Ser Thr Leu His  Leu Val Leu Arg Leu  Arg Gly Gly Arg            
1095                 1100                 1105                            

gct  ctc gtc gcc cag tgt  ctg gtc tgc gtt cct  tgg gac gca cgg        3810
Ala  Leu Val Ala Gln Cys  Leu Val Cys Val Pro  Trp Asp Ala Arg            
1110                 1115                 1120                            

ccc  cca ccc gcc gcc ccc  agt ttc cgg cag gtg  agt tgt ctc aaa        3855
Pro  Pro Pro Ala Ala Pro  Ser Phe Arg Gln Val  Ser Cys Leu Lys            
1125                 1130                 1135                            

gag  ttg gtt gct cgg gtg  ttg cag cgg ctt tgt  gaa cgc gga gca        3900
Glu  Leu Val Ala Arg Val  Leu Gln Arg Leu Cys  Glu Arg Gly Ala            
1140                 1145                 1150                            

aag  aac gtc ctt gcc ttt  ggc ttc gct ttg ctc  gat gga gca cgc        3945
Lys  Asn Val Leu Ala Phe  Gly Phe Ala Leu Leu  Asp Gly Ala Arg            
1155                 1160                 1165                            

gga  ggc cct cct gag gca  ttc act act agc gtc  cgg tcc tac ctg        3990
Gly  Gly Pro Pro Glu Ala  Phe Thr Thr Ser Val  Arg Ser Tyr Leu            
1170                 1175                 1180                            

ccc  aac aca gtg acc gac  gct ctg aga ggt tca  ggt gcc tgg ggt        4035
Pro  Asn Thr Val Thr Asp  Ala Leu Arg Gly Ser  Gly Ala Trp Gly            
1185                 1190                 1195                            

ctg  ctg ctg cgg agg gtg  ggt gat gat gtt ctg  gtt cac ctc ctg        4080
Leu  Leu Leu Arg Arg Val  Gly Asp Asp Val Leu  Val His Leu Leu            
1200                 1205                 1210                            

gcc  cgg tgt gcc ctg ttc  gtg ctg gtg gct ccc  tcc tgc gca tac        4125
Ala  Arg Cys Ala Leu Phe  Val Leu Val Ala Pro  Ser Cys Ala Tyr            
1215                 1220                 1225                            

cag  gtc tgc gga ccc cca  ctt tat cag ctc ggc  gct gct act cag        4170
Gln  Val Cys Gly Pro Pro  Leu Tyr Gln Leu Gly  Ala Ala Thr Gln            
1230                 1235                 1240                            

gcc  cgc cca cca cca cac  gcc tca ggt cca aga  cgc cgg ctg ggc        4215
Ala  Arg Pro Pro Pro His  Ala Ser Gly Pro Arg  Arg Arg Leu Gly            
1245                 1250                 1255                            

tgc  gaa cgg gca tgg aat  cat agc gtg cgg gag  gca ggt gtg cct        4260
Cys  Glu Arg Ala Trp Asn  His Ser Val Arg Glu  Ala Gly Val Pro            
1260                 1265                 1270                            

ctc  ggc ctg cca gcc ccc  gga gca agg aga cgc  ggt gga tcc gcc        4305
Leu  Gly Leu Pro Ala Pro  Gly Ala Arg Arg Arg  Gly Gly Ser Ala            
1275                 1280                 1285                            

agt  cgc tca ctc ccc ttg  cct aag agg cca aga  aga gga gcc gcc        4350
Ser  Arg Ser Leu Pro Leu  Pro Lys Arg Pro Arg  Arg Gly Ala Ala            
1290                 1295                 1300                            

cct  gaa ccc gag aga aca  cct gtc ggc cag ggc  tcc tgg gct cac        4395
Pro  Glu Pro Glu Arg Thr  Pro Val Gly Gln Gly  Ser Trp Ala His            
1305                 1310                 1315                            

ccc  gga agg acc agg ggc  cca agc gat agg ggc  ttc tgt gtt gtg        4440
Pro  Gly Arg Thr Arg Gly  Pro Ser Asp Arg Gly  Phe Cys Val Val            
1320                 1325                 1330                            

tca  cca gcc agg cct gcc  gaa gag gct acc tcc  ttg gaa gga gcc        4485
Ser  Pro Ala Arg Pro Ala  Glu Glu Ala Thr Ser  Leu Glu Gly Ala            
1335                 1340                 1345                            

ctc  agt ggc acc agg cat  tct cat cca tct gtg  ggt agg cag cat        4530
Leu  Ser Gly Thr Arg His  Ser His Pro Ser Val  Gly Arg Gln His            
1350                 1355                 1360                            

cat  gcc ggc ccc ccc tct  aca agc aga cct ccc  aga cct tgg gac        4575
His  Ala Gly Pro Pro Ser  Thr Ser Arg Pro Pro  Arg Pro Trp Asp            
1365                 1370                 1375                            

aca  ccc tgc cca cca gtg  tat gcc gag acc aag  cac ttt ttg tat        4620
Thr  Pro Cys Pro Pro Val  Tyr Ala Glu Thr Lys  His Phe Leu Tyr            
1380                 1385                 1390                            

tcc  agt ggc gat aaa gag  cag ctc cgg ccc tct  ttt ctg ctc tca        4665
Ser  Ser Gly Asp Lys Glu  Gln Leu Arg Pro Ser  Phe Leu Leu Ser            
1395                 1400                 1405                            

agc  ctc cgc ccc tct ctg  acc gga gct cgc agg  ctg gtg gag acc        4710
Ser  Leu Arg Pro Ser Leu  Thr Gly Ala Arg Arg  Leu Val Glu Thr            
1410                 1415                 1420                            

atc  ttt ctg ggc tca aga  cca tgg atg cca ggc  acc ccc cgc aga        4755
Ile  Phe Leu Gly Ser Arg  Pro Trp Met Pro Gly  Thr Pro Arg Arg            
1425                 1430                 1435                            

ctg  ccc agg ctc ccc cag  cgg tac tgg cag atg  cgc cct ctc ttt        4800
Leu  Pro Arg Leu Pro Gln  Arg Tyr Trp Gln Met  Arg Pro Leu Phe            
1440                 1445                 1450                            

ctg  gaa ctt ctg ggt aac  cac gcc cag tgc cca  tat ggc gtc ctg        4845
Leu  Glu Leu Leu Gly Asn  His Ala Gln Cys Pro  Tyr Gly Val Leu            
1455                 1460                 1465                            

ctg  aag acc cac tgt cct  ctg agg gcc gcc gtg  acc cca gcc gcc        4890
Leu  Lys Thr His Cys Pro  Leu Arg Ala Ala Val  Thr Pro Ala Ala            
1470                 1475                 1480                            

ggt  gtg tgt gct aga gaa  aaa ccc cag ggc tca  gtg gct gca cct        4935
Gly  Val Cys Ala Arg Glu  Lys Pro Gln Gly Ser  Val Ala Ala Pro            
1485                 1490                 1495                            

gaa  gag gag gac act gac  cct cgc cgc ctt gtc  cag ttg ctc agg        4980
Glu  Glu Glu Asp Thr Asp  Pro Arg Arg Leu Val  Gln Leu Leu Arg            
1500                 1505                 1510                            

cag  cat tca tca cca tgg  cag gtg tac ggc ttc  gtg agg gct tgc        5025
Gln  His Ser Ser Pro Trp  Gln Val Tyr Gly Phe  Val Arg Ala Cys            
1515                 1520                 1525                            

ctg  cgg aga ctg gtc ccc  ccc gga ttg tgg gga  tct cgg cac aac        5070
Leu  Arg Arg Leu Val Pro  Pro Gly Leu Trp Gly  Ser Arg His Asn            
1530                 1535                 1540                            

gaa  cgg cgc ttt ctg agg  aat aca aag aag ttt  atc tcc ctg ggc        5115
Glu  Arg Arg Phe Leu Arg  Asn Thr Lys Lys Phe  Ile Ser Leu Gly            
1545                 1550                 1555                            

aag  cat gca aag ctc agc  ttg cag gag ctg aca  tgg aag atg agc        5160
Lys  His Ala Lys Leu Ser  Leu Gln Glu Leu Thr  Trp Lys Met Ser            
1560                 1565                 1570                            

gtt  aga gga tgc gca tgg  ctc agg cgg tca cct  gga gtt gga tgc        5205
Val  Arg Gly Cys Ala Trp  Leu Arg Arg Ser Pro  Gly Val Gly Cys            
1575                 1580                 1585                            

gtt  cca gca gca gag cac  agg ctg cgc gaa gag  att ctc gca aag        5250
Val  Pro Ala Ala Glu His  Arg Leu Arg Glu Glu  Ile Leu Ala Lys            
1590                 1595                 1600                            

ttc  ctg cac tgg ctt atg  agc gtc tac gtg gtc  gaa ctg ctg cgg        5295
Phe  Leu His Trp Leu Met  Ser Val Tyr Val Val  Glu Leu Leu Arg            
1605                 1610                 1615                            

tct  ttc ttc tac gtg aca  gag acc act ttt cag  aag aac aga ctg        5340
Ser  Phe Phe Tyr Val Thr  Glu Thr Thr Phe Gln  Lys Asn Arg Leu            
1620                 1625                 1630                            

ttc  ttc tac agg aag tcc  gtc tgg agc aag ctc  cag agt att ggt        5385
Phe  Phe Tyr Arg Lys Ser  Val Trp Ser Lys Leu  Gln Ser Ile Gly            
1635                 1640                 1645                            

att  aga cag cac ctt aag  aga gtt cag ctt aga  gag ctg tcc gaa        5430
Ile  Arg Gln His Leu Lys  Arg Val Gln Leu Arg  Glu Leu Ser Glu            
1650                 1655                 1660                            

gct  gaa gtc cgc cag cac  cgc gaa gct cgc ccc  gcc ctc ctg acc        5475
Ala  Glu Val Arg Gln His  Arg Glu Ala Arg Pro  Ala Leu Leu Thr            
1665                 1670                 1675                            

tct  cgg ctg cgg ttt att  ccc aaa ccc gat ggc  ctt aga cct atc        5520
Ser  Arg Leu Arg Phe Ile  Pro Lys Pro Asp Gly  Leu Arg Pro Ile            
1680                 1685                 1690                            

gtg  aat atg gat tac gtc  gtg ggt gcc cgc act  ttc aga agg gag        5565
Val  Asn Met Asp Tyr Val  Val Gly Ala Arg Thr  Phe Arg Arg Glu            
1695                 1700                 1705                            

aag  agg gcc gag aga ctg  aca tct cgc gtg aag  gca ctt ttt tct        5610
Lys  Arg Ala Glu Arg Leu  Thr Ser Arg Val Lys  Ala Leu Phe Ser            
1710                 1715                 1720                            

gtg  ctt aat tat gaa aga  gcc cgc aga cct ggt  ctt ctc gga gcc        5655
Val  Leu Asn Tyr Glu Arg  Ala Arg Arg Pro Gly  Leu Leu Gly Ala            
1725                 1730                 1735                            

agc  gtg ctc ggc ctg gat  gat atc cat cgg gct  tgg cgc acc ttt        5700
Ser  Val Leu Gly Leu Asp  Asp Ile His Arg Ala  Trp Arg Thr Phe            
1740                 1745                 1750                            

gtg  ctt cgg gtg agg gca  cag gat cct cct cct  gag ctt tat ttt        5745
Val  Leu Arg Val Arg Ala  Gln Asp Pro Pro Pro  Glu Leu Tyr Phe            
1755                 1760                 1765                            

gtg  aaa gtt gat gtt act  ggt gct tac gat aca  atc cct cag gac        5790
Val  Lys Val Asp Val Thr  Gly Ala Tyr Asp Thr  Ile Pro Gln Asp            
1770                 1775                 1780                            

cgg  ctc acc gag gtg atc  gcc tct att atc aaa  ccc cag aac acc        5835
Arg  Leu Thr Glu Val Ile  Ala Ser Ile Ile Lys  Pro Gln Asn Thr            
1785                 1790                 1795                            

tac  tgc gtg aga agg tac  gcc gtc gtt cag aaa  gcc gca cac gga        5880
Tyr  Cys Val Arg Arg Tyr  Ala Val Val Gln Lys  Ala Ala His Gly            
1800                 1805                 1810                            

cac  gtg cgc aaa gct ttc  aaa tcc cac gtg tct  acc ttg aca gac        5925
His  Val Arg Lys Ala Phe  Lys Ser His Val Ser  Thr Leu Thr Asp            
1815                 1820                 1825                            

ctc  cag cct tat atg cgg  cag ttt gtc gca cac  ctg cag gag act        5970
Leu  Gln Pro Tyr Met Arg  Gln Phe Val Ala His  Leu Gln Glu Thr            
1830                 1835                 1840                            

agc  ccc ttg agg gac gct  gtg gtc atc gaa cag  tcc agc tct ctc        6015
Ser  Pro Leu Arg Asp Ala  Val Val Ile Glu Gln  Ser Ser Ser Leu            
1845                 1850                 1855                            

aat  gag gca tcc tca ggc  ctg ttt gat gtg ttc  ctg cgc ttt atg        6060
Asn  Glu Ala Ser Ser Gly  Leu Phe Asp Val Phe  Leu Arg Phe Met            
1860                 1865                 1870                            

tgc  cac cac gcc gtg cgg  att agg ggc aag tct  tac gtg cag tgc        6105
Cys  His His Ala Val Arg  Ile Arg Gly Lys Ser  Tyr Val Gln Cys            
1875                 1880                 1885                            

cag  ggc atc cca cag ggt  agc atc ctg agc aca  ctg ctg tgt agc        6150
Gln  Gly Ile Pro Gln Gly  Ser Ile Leu Ser Thr  Leu Leu Cys Ser            
1890                 1895                 1900                            

ctg  tgc tat ggc gat atg  gag aat aaa ttg ttc  gcc ggt atc aga        6195
Leu  Cys Tyr Gly Asp Met  Glu Asn Lys Leu Phe  Ala Gly Ile Arg            
1905                 1910                 1915                            

aga  gac ggt ttg ctc ctg  agg ctg ttc ctg ctg  gtt acc ccc cat        6240
Arg  Asp Gly Leu Leu Leu  Arg Leu Phe Leu Leu  Val Thr Pro His            
1920                 1925                 1930                            

ctg  act cat gcc aaa aca  ttt ttg cgg act ctg  gtt agg ggc gtg        6285
Leu  Thr His Ala Lys Thr  Phe Leu Arg Thr Leu  Val Arg Gly Val            
1935                 1940                 1945                            

cca  gag tat ggc tgt gtt  gtg aat ttg cgg aaa  act gtg gtt aat        6330
Pro  Glu Tyr Gly Cys Val  Val Asn Leu Arg Lys  Thr Val Val Asn            
1950                 1955                 1960                            

ttc  cca gtg gag gac gaa  gct ctc gga ggc aca  gct ttt gtt cag        6375
Phe  Pro Val Glu Asp Glu  Ala Leu Gly Gly Thr  Ala Phe Val Gln            
1965                 1970                 1975                            

atg  cct gcc cac ggc ctg  ttc cca tgg tgc gga  ctg ctg ctc gat        6420
Met  Pro Ala His Gly Leu  Phe Pro Trp Cys Gly  Leu Leu Leu Asp            
1980                 1985                 1990                            

acc  cgg acc ctc gag gtg  cag tcc gat tat agt  tcc tat gca aga        6465
Thr  Arg Thr Leu Glu Val  Gln Ser Asp Tyr Ser  Ser Tyr Ala Arg            
1995                 2000                 2005                            

aca  tca att cgg gct agc  ctg act ttc aac agg  ggc ttc aag gcc        6510
Thr  Ser Ile Arg Ala Ser  Leu Thr Phe Asn Arg  Gly Phe Lys Ala            
2010                 2015                 2020                            

ggc  cgg aat atg aga agg  aaa ctg ttc gga gtg  ttg aga ctt aag        6555
Gly  Arg Asn Met Arg Arg  Lys Leu Phe Gly Val  Leu Arg Leu Lys            
2025                 2030                 2035                            

tgt  cat agt ctt ttt ttg  gac ttg cag gtc aat  tct ctc cag aca        6600
Cys  His Ser Leu Phe Leu  Asp Leu Gln Val Asn  Ser Leu Gln Thr            
2040                 2045                 2050                            

gtg  tgt acc aac att tat  aaa atc ctc ttg ctg  cag gct tac aga        6645
Val  Cys Thr Asn Ile Tyr  Lys Ile Leu Leu Leu  Gln Ala Tyr Arg            
2055                 2060                 2065                            

ttc  cat gcc tgc gtc ctg  cag ctg cct ttc cac  cag cag gtg tgg        6690
Phe  His Ala Cys Val Leu  Gln Leu Pro Phe His  Gln Gln Val Trp            
2070                 2075                 2080                            

aaa  aac cct acc ttc ttc  ctg cgg gtg att agc  gac acc gcc agt        6735
Lys  Asn Pro Thr Phe Phe  Leu Arg Val Ile Ser  Asp Thr Ala Ser            
2085                 2090                 2095                            

ctt  tgc tac tcc atc ttg  aaa gca aaa aac gct  ggc atg agc ttg        6780
Leu  Cys Tyr Ser Ile Leu  Lys Ala Lys Asn Ala  Gly Met Ser Leu            
2100                 2105                 2110                            

gga  gct aag ggc gcc gct  gga cct ctg ccc agt  gaa gca gtc cag        6825
Gly  Ala Lys Gly Ala Ala  Gly Pro Leu Pro Ser  Glu Ala Val Gln            
2115                 2120                 2125                            

tgg  ctg tgt cat cag gct  ttc ctc ctt aaa ctg  aca cgc cac cgc        6870
Trp  Leu Cys His Gln Ala  Phe Leu Leu Lys Leu  Thr Arg His Arg            
2130                 2135                 2140                            

gtg  act tac gtc cca ctc  ctg ggc tcc ctg aga  act gct cag acc        6915
Val  Thr Tyr Val Pro Leu  Leu Gly Ser Leu Arg  Thr Ala Gln Thr            
2145                 2150                 2155                            

cag  ctt tcc cgg aag ctt  cca ggc act acc ctt  acc gca ctc gaa        6960
Gln  Leu Ser Arg Lys Leu  Pro Gly Thr Thr Leu  Thr Ala Leu Glu            
2160                 2165                 2170                            

gca  gcc gcc aac cct gcc  ctg ccc tcc gac ttt  aag act atc ctg        7005
Ala  Ala Ala Asn Pro Ala  Leu Pro Ser Asp Phe  Lys Thr Ile Leu            
2175                 2180                 2185                            

gac  aca gag ctg aag ttg  agc gat tac gag ggc  cgc ctg atc cag        7050
Asp  Thr Glu Leu Lys Leu  Ser Asp Tyr Glu Gly  Arg Leu Ile Gln            
2190                 2195                 2200                            

aac  tcc ttg act ggc aag  cca att cct aat cca  ttg ctg ggc ctg        7095
Asn  Ser Leu Thr Gly Lys  Pro Ile Pro Asn Pro  Leu Leu Gly Leu            
2205                 2210                 2215                            

gac  tca act tga gcgcgcagcg ctgacgtctc gcgatcgata ctagtacaac          7147
Asp  Ser Thr                                                              
2220                                                                      

ctaaatccat tataaaaaac ttaggagcaa agtgattgcc tcccaaggtc caca atg       7204
                                                            Met           
                                                                          

aca gag  acc tac gac ttc gac  aag tcg gca tgg gac  atc aaa ggg        7249
Thr Glu  Thr Tyr Asp Phe Asp  Lys Ser Ala Trp Asp  Ile Lys Gly            
    2225                 2230                 2235                        

tcg atc  gct ccg ata caa ccc  acc acc tac agt gat  ggc agg ctg        7294
Ser Ile  Ala Pro Ile Gln Pro  Thr Thr Tyr Ser Asp  Gly Arg Leu            
    2240                 2245                 2250                        

gtg ccc  cag gtc aga gtc ata  gat cct ggt cta ggc  gac agg aag        7339
Val Pro  Gln Val Arg Val Ile  Asp Pro Gly Leu Gly  Asp Arg Lys            
    2255                 2260                 2265                        

gat gaa  tgc ttt atg tac atg  ttt ctg ctg ggg gtt  gtt gag gac        7384
Asp Glu  Cys Phe Met Tyr Met  Phe Leu Leu Gly Val  Val Glu Asp            
    2270                 2275                 2280                        

agc gat  tcc cta ggg cct cca  atc ggg cga gca ttt  ggg ttc ctg        7429
Ser Asp  Ser Leu Gly Pro Pro  Ile Gly Arg Ala Phe  Gly Phe Leu            
    2285                 2290                 2295                        

ccc tta  ggt gtt ggc aga tcc  aca gca aag ccc gaa  aaa ctc ctc        7474
Pro Leu  Gly Val Gly Arg Ser  Thr Ala Lys Pro Glu  Lys Leu Leu            
    2300                 2305                 2310                        

aaa gag  gcc act gag ctt gac  ata gtt gtt aga cgt  aca gca ggg        7519
Lys Glu  Ala Thr Glu Leu Asp  Ile Val Val Arg Arg  Thr Ala Gly            
    2315                 2320                 2325                        

ctc aat  gaa aaa ctg gtg ttc  tac aac aac acc cca  cta act ctc        7564
Leu Asn  Glu Lys Leu Val Phe  Tyr Asn Asn Thr Pro  Leu Thr Leu            
    2330                 2335                 2340                        

ctc aca  cct tgg aga aag gtc  cta aca aca ggg agt  gtc ttc aac        7609
Leu Thr  Pro Trp Arg Lys Val  Leu Thr Thr Gly Ser  Val Phe Asn            
    2345                 2350                 2355                        

gca aac  caa gtg tgc aat gcg  gtt aat ctg ata ccg  ctc gat acc        7654
Ala Asn  Gln Val Cys Asn Ala  Val Asn Leu Ile Pro  Leu Asp Thr            
    2360                 2365                 2370                        

ccg cag  agg ttc cgt gtt gtt  tat atg agc atc acc  cgt ctt tcg        7699
Pro Gln  Arg Phe Arg Val Val  Tyr Met Ser Ile Thr  Arg Leu Ser            
    2375                 2380                 2385                        

gat aac  ggg tat tac acc gtt  cct aga aga atg ctg  gaa ttc aga        7744
Asp Asn  Gly Tyr Tyr Thr Val  Pro Arg Arg Met Leu  Glu Phe Arg            
    2390                 2395                 2400                        

tcg gtc  aat gca gtg gcc ttc  aac ctg ctg gtg acc  ctt agg att        7789
Ser Val  Asn Ala Val Ala Phe  Asn Leu Leu Val Thr  Leu Arg Ile            
    2405                 2410                 2415                        

gac aag  gcg ata ggc cct ggg  aag atc atc gac aat  aca gag caa        7834
Asp Lys  Ala Ile Gly Pro Gly  Lys Ile Ile Asp Asn  Thr Glu Gln            
    2420                 2425                 2430                        

ctt cct  gag gca aca ttt atg  gtc cac atc ggg aac  ttc agg aga        7879
Leu Pro  Glu Ala Thr Phe Met  Val His Ile Gly Asn  Phe Arg Arg            
    2435                 2440                 2445                        

aag aag  agt gaa gtc tac tct  gcc gat tat tgc aaa  atg aaa atc        7924
Lys Lys  Ser Glu Val Tyr Ser  Ala Asp Tyr Cys Lys  Met Lys Ile            
    2450                 2455                 2460                        

gaa aag  atg ggc ctg gtt ttt  gca ctt ggt ggg ata  ggg ggc acc        7969
Glu Lys  Met Gly Leu Val Phe  Ala Leu Gly Gly Ile  Gly Gly Thr            
    2465                 2470                 2475                        

agt ctt  cac att aga agc aca  ggc aaa atg agc aag  act ctc cat        8014
Ser Leu  His Ile Arg Ser Thr  Gly Lys Met Ser Lys  Thr Leu His            
    2480                 2485                 2490                        

gca caa  ctc ggg ttc aag aag  acc tta tgt tac ccg  ctg atg gat        8059
Ala Gln  Leu Gly Phe Lys Lys  Thr Leu Cys Tyr Pro  Leu Met Asp            
    2495                 2500                 2505                        

atc aat  gaa gac ctt aat cga  tta ctc tgg agg agc  aga tgc aag        8104
Ile Asn  Glu Asp Leu Asn Arg  Leu Leu Trp Arg Ser  Arg Cys Lys            
    2510                 2515                 2520                        

ata gta  aga atc cag gca gtt  ttg cag cca tca gtt  cct caa gaa        8149
Ile Val  Arg Ile Gln Ala Val  Leu Gln Pro Ser Val  Pro Gln Glu            
    2525                 2530                 2535                        

ttc cgc  att tac gac gac gtg  atc ata aat gat gac  caa gga cta        8194
Phe Arg  Ile Tyr Asp Asp Val  Ile Ile Asn Asp Asp  Gln Gly Leu            
    2540                 2545                 2550                        

ttc aaa  gtt ctg tag accgtagtgc ccagcaatgc ccgaaaacga cccccctcac      8249
Phe Lys  Val Leu                                                          
    2555                                                                  

aatgacagcc agaaggcccg gacaaaaaag ccccctccga aagactccac ggaccaagcg     8309

agaggccagc cagcagccga cggcaagcgc gaacaccagg cggccccagc acagaacagc     8369

cctgacacaa ggccaccacc agccacccca atctgcatcc tcctcgtggg acccccgagg     8429

accaaccccc aaggctgccc ccgatccaaa ccaccaaccg catccccacc acccccggga     8489

aagaaacccc cagcaattgg aaggcccctc cccctcttcc tcaacacaag aactccacaa     8549

ccgaaccgca caagcgaccg aggtgaccca accgcaggca tccgactccc tagacagatc     8609

ctctctcccc ggcaaactaa acaaaactta gggccaagga acatacacac ccaacagaac     8669

ccagaccccg gcccacggcg ccgcgccccc aacccccgac aaccagaggg agcccccaac     8729

caatcccgcc ggctcccccg gtgcccacag gcagggacac caacccccga acagacccag     8789

cacccaacca tcgacaatcc aagacggggg ggccccccca aaaaaaggcc cccaggggcc     8849

gacagccagc accgcgagga agcccaccca ccccacacac gaccacggca accaaaccag     8909

aacccagacc accctgggcc accagctccc agactcggcc atcaccccgc agaaaggaaa     8969

ggccacaacc cgcgcacccc agccccgatc cggcggggag ccacccaacc cgaaccagca     9029

cccaagagcg atccccgaag gacccccgaa ccgcaaagga catcagtatc ccacagcctc     9089

tccaagtccc ccggtctcct cctcttctcg aagggaccaa aagatcaatc caccacaccc     9149

gacgacactc aactccccac ccctaaagga gacaccggga atcccagaat caagactcat     9209

cca atg tcc atc  atg ggt ctc aag gtg  aac gtc tct gcc ata  ttc        9254
    Met Ser Ile  Met Gly Leu Lys Val  Asn Val Ser Ala Ile  Phe            
            2560                 2565                 2570                

atg gca gta ctg  tta act ctc caa aca  ccc acc ggt caa atc  cat        9299
Met Ala Val Leu  Leu Thr Leu Gln Thr  Pro Thr Gly Gln Ile  His            
            2575                 2580                 2585                

tgg ggc aat ctc  tct aag ata ggg gtg  gta gga ata gga agt  gca        9344
Trp Gly Asn Leu  Ser Lys Ile Gly Val  Val Gly Ile Gly Ser  Ala            
            2590                 2595                 2600                

agc tac aaa gtt  atg act cgt tcc agc  cat caa tca tta gtc  ata        9389
Ser Tyr Lys Val  Met Thr Arg Ser Ser  His Gln Ser Leu Val  Ile            
            2605                 2610                 2615                

aaa tta atg ccc  aat ata act ctc ctc  aat aac tgc acg agg  gta        9434
Lys Leu Met Pro  Asn Ile Thr Leu Leu  Asn Asn Cys Thr Arg  Val            
            2620                 2625                 2630                

gag att gca gaa  tac agg aga cta ctg  aga aca gtt ttg gaa  cca        9479
Glu Ile Ala Glu  Tyr Arg Arg Leu Leu  Arg Thr Val Leu Glu  Pro            
            2635                 2640                 2645                

att aga gat gca  ctt aat gca atg acc  cag aat ata aga ccg  gtt        9524
Ile Arg Asp Ala  Leu Asn Ala Met Thr  Gln Asn Ile Arg Pro  Val            
            2650                 2655                 2660                

cag agt gta gct  tca agt agg aga cac  aag aga ttt gcg gga  gta        9569
Gln Ser Val Ala  Ser Ser Arg Arg His  Lys Arg Phe Ala Gly  Val            
            2665                 2670                 2675                

gtc ctg gca ggt  gcg gcc cta ggc gtt  gcc aca gct gct cag  ata        9614
Val Leu Ala Gly  Ala Ala Leu Gly Val  Ala Thr Ala Ala Gln  Ile            
            2680                 2685                 2690                

aca gcc ggc att  gca ctt cac cag tcc  atg ctg aac tct caa  gcc        9659
Thr Ala Gly Ile  Ala Leu His Gln Ser  Met Leu Asn Ser Gln  Ala            
            2695                 2700                 2705                

atc gac aat ctg  aga gcg agc ctg gaa  act act aat cag gca  att        9704
Ile Asp Asn Leu  Arg Ala Ser Leu Glu  Thr Thr Asn Gln Ala  Ile            
            2710                 2715                 2720                

gag aca atc aga  caa gca ggg cag gag  atg ata ttg gct gtt  cag        9749
Glu Thr Ile Arg  Gln Ala Gly Gln Glu  Met Ile Leu Ala Val  Gln            
            2725                 2730                 2735                

ggt gtc caa gac  tac atc aat aat gag  ctg ata ccg tct atg  aac        9794
Gly Val Gln Asp  Tyr Ile Asn Asn Glu  Leu Ile Pro Ser Met  Asn            
            2740                 2745                 2750                

caa cta tct tgt  gat tta atc ggc cag  aag ctc ggg ctc aaa  ttg        9839
Gln Leu Ser Cys  Asp Leu Ile Gly Gln  Lys Leu Gly Leu Lys  Leu            
            2755                 2760                 2765                

ctc aga tac tat  aca gaa atc ctg tca  tta ttt ggc ccc agt  tta        9884
Leu Arg Tyr Tyr  Thr Glu Ile Leu Ser  Leu Phe Gly Pro Ser  Leu            
            2770                 2775                 2780                

cgg gac ccc ata  tct gcg gag ata tct  atc cag gct ttg agc  tat        9929
Arg Asp Pro Ile  Ser Ala Glu Ile Ser  Ile Gln Ala Leu Ser  Tyr            
            2785                 2790                 2795                

gcg ctt gga gga  gac atc aat aag gtg  tta gaa aag ctc gga  tac        9974
Ala Leu Gly Gly  Asp Ile Asn Lys Val  Leu Glu Lys Leu Gly  Tyr            
            2800                 2805                 2810                

agt gga ggt gat  tta ctg ggc atc tta  gag agc gga gga ata  aag       10019
Ser Gly Gly Asp  Leu Leu Gly Ile Leu  Glu Ser Gly Gly Ile  Lys            
            2815                 2820                 2825                

gcc cgg ata act  cac gtc gac aca gag  tcc tac ttc att gtc  ctc       10064
Ala Arg Ile Thr  His Val Asp Thr Glu  Ser Tyr Phe Ile Val  Leu            
            2830                 2835                 2840                

agt ata gcc tat  ccg acg ctg tcc gag  att aag ggg gtg att  gtc       10109
Ser Ile Ala Tyr  Pro Thr Leu Ser Glu  Ile Lys Gly Val Ile  Val            
            2845                 2850                 2855                

cac cgg cta gag  ggg gtc tcg tac aac  ata ggc tct caa gag  tgg       10154
His Arg Leu Glu  Gly Val Ser Tyr Asn  Ile Gly Ser Gln Glu  Trp            
            2860                 2865                 2870                

tat acc act gtg  ccc aag tat gtt gca  acc caa ggg tac ctt  atc       10199
Tyr Thr Thr Val  Pro Lys Tyr Val Ala  Thr Gln Gly Tyr Leu  Ile            
            2875                 2880                 2885                

tcg aat ttt gat  gag tca tcg tgt act  ttc atg cca gag ggg  act       10244
Ser Asn Phe Asp  Glu Ser Ser Cys Thr  Phe Met Pro Glu Gly  Thr            
            2890                 2895                 2900                

gtg tgc agc caa  aat gcc ttg tac ccg  atg agt cct ctg ctc  caa       10289
Val Cys Ser Gln  Asn Ala Leu Tyr Pro  Met Ser Pro Leu Leu  Gln            
            2905                 2910                 2915                

gaa tgc ctc cgg  ggg tac acc aag tcc  tgt gct cgt aca ctc  gta       10334
Glu Cys Leu Arg  Gly Tyr Thr Lys Ser  Cys Ala Arg Thr Leu  Val            
            2920                 2925                 2930                

tcc ggg tct ttt  ggg aac cgg ttc att  tta tca caa ggg aac  cta       10379
Ser Gly Ser Phe  Gly Asn Arg Phe Ile  Leu Ser Gln Gly Asn  Leu            
            2935                 2940                 2945                

ata gcc aat tgt  gca tca atc ctt tgc  aag tgt tac aca aca  gga       10424
Ile Ala Asn Cys  Ala Ser Ile Leu Cys  Lys Cys Tyr Thr Thr  Gly            
            2950                 2955                 2960                

acg atc att aat  caa gac cct gac aag  atc cta aca tac att  gct       10469
Thr Ile Ile Asn  Gln Asp Pro Asp Lys  Ile Leu Thr Tyr Ile  Ala            
            2965                 2970                 2975                

gcc gat cac tgc  ccg gta gtc gag gtg  aac ggc gtg acc atc  caa       10514
Ala Asp His Cys  Pro Val Val Glu Val  Asn Gly Val Thr Ile  Gln            
            2980                 2985                 2990                

gtc ggg agc agg  agg tat cca gac gct  gtg tac ttg cac aga  att       10559
Val Gly Ser Arg  Arg Tyr Pro Asp Ala  Val Tyr Leu His Arg  Ile            
            2995                 3000                 3005                

gac ctc ggt cct  ccc ata tca ttg gag  agg ttg gac gta ggg  aca       10604
Asp Leu Gly Pro  Pro Ile Ser Leu Glu  Arg Leu Asp Val Gly  Thr            
            3010                 3015                 3020                

aat ctg ggg aat  gca att gct aag ttg  gag gat gcc aag gaa  ttg       10649
Asn Leu Gly Asn  Ala Ile Ala Lys Leu  Glu Asp Ala Lys Glu  Leu            
            3025                 3030                 3035                

ttg gag tca tcg  gac cag ata ttg agg  agt atg aaa ggt tta  tcg       10694
Leu Glu Ser Ser  Asp Gln Ile Leu Arg  Ser Met Lys Gly Leu  Ser            
            3040                 3045                 3050                

agc act agc ata  gtc tac atc ctg att  gca gtg tgt ctt gga  ggg       10739
Ser Thr Ser Ile  Val Tyr Ile Leu Ile  Ala Val Cys Leu Gly  Gly            
            3055                 3060                 3065                

ttg ata ggg atc  ccc gct tta ata tgt  tgc tgc agg ggg cgt  tgt       10784
Leu Ile Gly Ile  Pro Ala Leu Ile Cys  Cys Cys Arg Gly Arg  Cys            
            3070                 3075                 3080                

aac aaa aag gga  gaa caa gtt ggt atg  tca aga cca ggc cta  aag       10829
Asn Lys Lys Gly  Glu Gln Val Gly Met  Ser Arg Pro Gly Leu  Lys            
            3085                 3090                 3095                

cct gat ctt acg  gga aca tca aaa tcc  tat gta agg tcg ctc  tga       10874
Pro Asp Leu Thr  Gly Thr Ser Lys Ser  Tyr Val Arg Ser Leu                 
            3100                 3105                 3110                

tcctctacaa ctcttgaaac acaaatgtcc cacaagtctc ctcttcgtca tcaagcaacc    10934

accgcaccca gcatcaagcc cacctgaaat tatctccggc ttccctctgg ccgaacaata    10994

tcggtagtta atcaaaactt agggtgcaag atcatccaca atg tca cca caa cga      11049
                                            Met Ser Pro Gln Arg           
                                                            3115          

gac cgg ata aat gcc  ttc tac aaa gat aac  ccc cat ccc aag gga        11094
Asp Arg Ile Asn Ala  Phe Tyr Lys Asp Asn  Pro His Pro Lys Gly             
                3120                 3125                 3130            

agt agg ata gtc att  aac aga gaa cat ctt  atg att gat aga cct        11139
Ser Arg Ile Val Ile  Asn Arg Glu His Leu  Met Ile Asp Arg Pro             
                3135                 3140                 3145            

tat gtt ttg ctg gct  gtt ctg ttt gtc atg  ttt ctg agc ttg atc        11184
Tyr Val Leu Leu Ala  Val Leu Phe Val Met  Phe Leu Ser Leu Ile             
                3150                 3155                 3160            

ggg ttg cta gcc att  gca ggc att aga ctt  cat cgg gca gcc atc        11229
Gly Leu Leu Ala Ile  Ala Gly Ile Arg Leu  His Arg Ala Ala Ile             
                3165                 3170                 3175            

tac acc gca gag atc  cat aaa agc ctc agc  acc aat cta gat gta        11274
Tyr Thr Ala Glu Ile  His Lys Ser Leu Ser  Thr Asn Leu Asp Val             
                3180                 3185                 3190            

act aac tca atc gag  cat cag gtc aag gac  gtg ctg aca cca ctc        11319
Thr Asn Ser Ile Glu  His Gln Val Lys Asp  Val Leu Thr Pro Leu             
                3195                 3200                 3205            

ttc aaa atc atc ggt  gat gaa gtg ggc ctg  agg aca cct cag aga        11364
Phe Lys Ile Ile Gly  Asp Glu Val Gly Leu  Arg Thr Pro Gln Arg             
                3210                 3215                 3220            

ttc act gac cta gtg  aaa tta atc tct gac  aag att aaa ttc ctt        11409
Phe Thr Asp Leu Val  Lys Leu Ile Ser Asp  Lys Ile Lys Phe Leu             
                3225                 3230                 3235            

aat ccg gat agg gag  tac gac ttc aga gat  ctc act tgg tgt atc        11454
Asn Pro Asp Arg Glu  Tyr Asp Phe Arg Asp  Leu Thr Trp Cys Ile             
                3240                 3245                 3250            

aac ccg cca gag aga  atc aaa ttg gat tat  gat caa tac tgt gca        11499
Asn Pro Pro Glu Arg  Ile Lys Leu Asp Tyr  Asp Gln Tyr Cys Ala             
                3255                 3260                 3265            

gat gtg gct gct gaa  gag ctc atg aat gca  ttg gtg aac tca act        11544
Asp Val Ala Ala Glu  Glu Leu Met Asn Ala  Leu Val Asn Ser Thr             
                3270                 3275                 3280            

cta ctg gag acc aga  aca acc aat cag ttc  cta gct gtc tca aag        11589
Leu Leu Glu Thr Arg  Thr Thr Asn Gln Phe  Leu Ala Val Ser Lys             
                3285                 3290                 3295            

gga aac tgc tca ggg  ccc act aca atc aga  ggt caa ttc tca aac        11634
Gly Asn Cys Ser Gly  Pro Thr Thr Ile Arg  Gly Gln Phe Ser Asn             
                3300                 3305                 3310            

atg tcg ctg tcc ctg  tta gac ttg tat tta  ggt cga ggt tac aat        11679
Met Ser Leu Ser Leu  Leu Asp Leu Tyr Leu  Gly Arg Gly Tyr Asn             
                3315                 3320                 3325            

gtg tca tct ata gtc  act atg aca tcc cag  gga atg tat ggg gga        11724
Val Ser Ser Ile Val  Thr Met Thr Ser Gln  Gly Met Tyr Gly Gly             
                3330                 3335                 3340            

act tac cta gtg gaa  aag cct aat ctg agc  agc aaa agg tca gag        11769
Thr Tyr Leu Val Glu  Lys Pro Asn Leu Ser  Ser Lys Arg Ser Glu             
                3345                 3350                 3355            

ttg tca caa ctg agc  atg tac cga gtg ttt  gaa gta ggt gtt atc        11814
Leu Ser Gln Leu Ser  Met Tyr Arg Val Phe  Glu Val Gly Val Ile             
                3360                 3365                 3370            

aga aat ccg ggt ttg  ggg gct ccg gtg ttc  cat atg aca aac tat        11859
Arg Asn Pro Gly Leu  Gly Ala Pro Val Phe  His Met Thr Asn Tyr             
                3375                 3380                 3385            

ctt gag caa cca gtc  agt aat gat ctc agc  aac tgt atg gtg gct        11904
Leu Glu Gln Pro Val  Ser Asn Asp Leu Ser  Asn Cys Met Val Ala             
                3390                 3395                 3400            

ttg ggg gag ctc aaa  ctc gca gcc ctt tgt  cac ggg gaa gat tct        11949
Leu Gly Glu Leu Lys  Leu Ala Ala Leu Cys  His Gly Glu Asp Ser             
                3405                 3410                 3415            

atc aca att ccc tat  cag gga tca ggg aaa  ggt gtc agc ttc cag        11994
Ile Thr Ile Pro Tyr  Gln Gly Ser Gly Lys  Gly Val Ser Phe Gln             
                3420                 3425                 3430            

ctc gtc aag cta ggt  gtc tgg aaa tcc cca  acc gac atg caa tcc        12039
Leu Val Lys Leu Gly  Val Trp Lys Ser Pro  Thr Asp Met Gln Ser             
                3435                 3440                 3445            

tgg gtc ccc tta tca  acg gat gat cca gtg  ata gac agg ctt tac        12084
Trp Val Pro Leu Ser  Thr Asp Asp Pro Val  Ile Asp Arg Leu Tyr             
                3450                 3455                 3460            

ctc tca tct cac aga  ggt gtt atc gct gac  aat caa gca aaa tgg        12129
Leu Ser Ser His Arg  Gly Val Ile Ala Asp  Asn Gln Ala Lys Trp             
                3465                 3470                 3475            

gct gtc ccg aca aca  cga aca gat gac aag  ttg cga atg gag aca        12174
Ala Val Pro Thr Thr  Arg Thr Asp Asp Lys  Leu Arg Met Glu Thr             
                3480                 3485                 3490            

tgc ttc caa cag gcg  tgt aag ggt aaa atc  caa gca ctc tgc gag        12219
Cys Phe Gln Gln Ala  Cys Lys Gly Lys Ile  Gln Ala Leu Cys Glu             
                3495                 3500                 3505            

aat ccc gag tgg gca  cca ttg aag gat aac  agg att cct tca tac        12264
Asn Pro Glu Trp Ala  Pro Leu Lys Asp Asn  Arg Ile Pro Ser Tyr             
                3510                 3515                 3520            

ggg gtc ttg tct gtt  gat ctg agt ctg aca  gtt gag ctt aaa atc        12309
Gly Val Leu Ser Val  Asp Leu Ser Leu Thr  Val Glu Leu Lys Ile             
                3525                 3530                 3535            

aaa att gct tcg gga  ttc ggg cca ttg atc  aca cac ggt tca ggg        12354
Lys Ile Ala Ser Gly  Phe Gly Pro Leu Ile  Thr His Gly Ser Gly             
                3540                 3545                 3550            

atg gac cta tac aaa  tcc aac cac aac aat  gtg tat tgg ctg act        12399
Met Asp Leu Tyr Lys  Ser Asn His Asn Asn  Val Tyr Trp Leu Thr             
                3555                 3560                 3565            

atc ccg cca atg aag  aac cta gcc tta ggt  gta atc aac aca ttg        12444
Ile Pro Pro Met Lys  Asn Leu Ala Leu Gly  Val Ile Asn Thr Leu             
                3570                 3575                 3580            

gag tgg ata ccg aga  ttc aag gtt agt ccc  tac ctc ttc act gtc        12489
Glu Trp Ile Pro Arg  Phe Lys Val Ser Pro  Tyr Leu Phe Thr Val             
                3585                 3590                 3595            

cca att aag gaa gca  ggc gaa gac tgc cat  gcc cca aca tac cta        12534
Pro Ile Lys Glu Ala  Gly Glu Asp Cys His  Ala Pro Thr Tyr Leu             
                3600                 3605                 3610            

cct gcg gag gtg gat  ggt gat gtc aaa ctc  agt tcc aat ctg gtg        12579
Pro Ala Glu Val Asp  Gly Asp Val Lys Leu  Ser Ser Asn Leu Val             
                3615                 3620                 3625            

att cta cct ggt caa  gat ctc caa tat gtt  ttg gca acc tac gat        12624
Ile Leu Pro Gly Gln  Asp Leu Gln Tyr Val  Leu Ala Thr Tyr Asp             
                3630                 3635                 3640            

act tcc agg gtt gaa  cat gct gtg gtt tat  tac gtt tac agc cca        12669
Thr Ser Arg Val Glu  His Ala Val Val Tyr  Tyr Val Tyr Ser Pro             
                3645                 3650                 3655            

agc cgc tca ttt tct  tac ttt tat cct ttt  agg ttg cct ata aag        12714
Ser Arg Ser Phe Ser  Tyr Phe Tyr Pro Phe  Arg Leu Pro Ile Lys             
                3660                 3665                 3670            

ggg gtc ccc atc gaa  tta caa gtg gaa tgc  ttc aca tgg gac caa        12759
Gly Val Pro Ile Glu  Leu Gln Val Glu Cys  Phe Thr Trp Asp Gln             
                3675                 3680                 3685            

aaa ctc tgg tgc cgt  cac ttc tgt gtg ctt  gcg gac tca gaa tct        12804
Lys Leu Trp Cys Arg  His Phe Cys Val Leu  Ala Asp Ser Glu Ser             
                3690                 3695                 3700            

ggt gga cat atc act  cac tct ggg atg gtg  ggc atg gga gtc agc        12849
Gly Gly His Ile Thr  His Ser Gly Met Val  Gly Met Gly Val Ser             
                3705                 3710                 3715            

tgc aca gtc acc cgg  gaa gat gga acc aat  cgc aga tag ggctgctagt     12898
Cys Thr Val Thr Arg  Glu Asp Gly Thr Asn  Arg Arg                         
                3720                 3725                                 

gaaccaatca catgatgtca cccagacatc aggcataccc actagtgtga aatagacatc    12958

agaattaaga aaaacgtagg gtccaagtgg ttccccgtt atg gac tcg  cta tct      13012
                                           Met Asp Ser  Leu Ser           
                                                   3730                   

gtc aac cag  atc tta tac cct gaa  gtt cac cta gat agc  ccg ata       13057
Val Asn Gln  Ile Leu Tyr Pro Glu  Val His Leu Asp Ser  Pro Ile            
        3735                 3740                 3745                    

gtt acc aat  aag ata gta gcc atc  ctg gag tat gct cga  gtc cct       13102
Val Thr Asn  Lys Ile Val Ala Ile  Leu Glu Tyr Ala Arg  Val Pro            
        3750                 3755                 3760                    

cac gct tac  agc ctg gag gac cct  aca ctg tgt cag aac  atc aag       13147
His Ala Tyr  Ser Leu Glu Asp Pro  Thr Leu Cys Gln Asn  Ile Lys            
        3765                 3770                 3775                    

cac cgc cta  aaa aac gga ttt tcc  aac caa atg att ata  aac aat       13192
His Arg Leu  Lys Asn Gly Phe Ser  Asn Gln Met Ile Ile  Asn Asn            
        3780                 3785                 3790                    

gtg gaa gtt  ggg aat gtc atc aag  tcc aag ctt agg agt  tat ccg       13237
Val Glu Val  Gly Asn Val Ile Lys  Ser Lys Leu Arg Ser  Tyr Pro            
        3795                 3800                 3805                    

gcc cac tct  cat att cca tat cca  aat tgt aat cag gat  tta ttt       13282
Ala His Ser  His Ile Pro Tyr Pro  Asn Cys Asn Gln Asp  Leu Phe            
        3810                 3815                 3820                    

aac ata gaa  gac aaa gag tca acg  agg aag atc cgt gaa  ctc ctc       13327
Asn Ile Glu  Asp Lys Glu Ser Thr  Arg Lys Ile Arg Glu  Leu Leu            
        3825                 3830                 3835                    

aaa aag ggg  aat tcg ctg tac tcc  aaa gtc agt gat aag  gtt ttc       13372
Lys Lys Gly  Asn Ser Leu Tyr Ser  Lys Val Ser Asp Lys  Val Phe            
        3840                 3845                 3850                    

caa tgc tta  agg gac act aac tca  cgg ctt ggc cta ggc  tcc gaa       13417
Gln Cys Leu  Arg Asp Thr Asn Ser  Arg Leu Gly Leu Gly  Ser Glu            
        3855                 3860                 3865                    

ttg agg gag  gac atc aag gag aaa  gtt att aac ttg gga  gtt tac       13462
Leu Arg Glu  Asp Ile Lys Glu Lys  Val Ile Asn Leu Gly  Val Tyr            
        3870                 3875                 3880                    

atg cac agc  tcc cag tgg ttt gag  ccc ttt ctg ttt tgg  ttt aca       13507
Met His Ser  Ser Gln Trp Phe Glu  Pro Phe Leu Phe Trp  Phe Thr            
        3885                 3890                 3895                    

gtc aag act  gag atg agg tca gtg  att aaa tca caa acc  cat act       13552
Val Lys Thr  Glu Met Arg Ser Val  Ile Lys Ser Gln Thr  His Thr            
        3900                 3905                 3910                    

tgc cat agg  agg aga cac aca cct  gta ttc ttc act ggt  agt tca       13597
Cys His Arg  Arg Arg His Thr Pro  Val Phe Phe Thr Gly  Ser Ser            
        3915                 3920                 3925                    

gtt gag ttg  cta atc tct cgt gac  ctt gtt gct ata atc  agt aaa       13642
Val Glu Leu  Leu Ile Ser Arg Asp  Leu Val Ala Ile Ile  Ser Lys            
        3930                 3935                 3940                    

gag tct caa  cat gta tat tac ctg  aca ttt gaa ctg gtt  ttg atg       13687
Glu Ser Gln  His Val Tyr Tyr Leu  Thr Phe Glu Leu Val  Leu Met            
        3945                 3950                 3955                    

tat tgt gat  gtc ata gag ggg agg  tta atg aca gag acc  gct atg       13732
Tyr Cys Asp  Val Ile Glu Gly Arg  Leu Met Thr Glu Thr  Ala Met            
        3960                 3965                 3970                    

act att gat  gct agg tat aca gag  ctt cta gga aga gtc  aga tac       13777
Thr Ile Asp  Ala Arg Tyr Thr Glu  Leu Leu Gly Arg Val  Arg Tyr            
        3975                 3980                 3985                    

atg tgg aaa  ctg ata gat ggt ttc  ttc cct gca ctc ggg  aat cca       13822
Met Trp Lys  Leu Ile Asp Gly Phe  Phe Pro Ala Leu Gly  Asn Pro            
        3990                 3995                 4000                    

act tat caa  att gta gcc atg ctg  gag cct ctt tca ctt  gct tac       13867
Thr Tyr Gln  Ile Val Ala Met Leu  Glu Pro Leu Ser Leu  Ala Tyr            
        4005                 4010                 4015                    

ctg cag ctg  agg gat ata aca gta  gaa ctc aga ggt gct  ttc ctt       13912
Leu Gln Leu  Arg Asp Ile Thr Val  Glu Leu Arg Gly Ala  Phe Leu            
        4020                 4025                 4030                    

aac cac tgc  ttt act gaa ata cat  gat gtt ctt gac caa  aac ggg       13957
Asn His Cys  Phe Thr Glu Ile His  Asp Val Leu Asp Gln  Asn Gly            
        4035                 4040                 4045                    

ttt tct gat  gaa ggt act tat cat  gag tta act gaa gct  cta gat       14002
Phe Ser Asp  Glu Gly Thr Tyr His  Glu Leu Thr Glu Ala  Leu Asp            
        4050                 4055                 4060                    

tac att ttc  ata act gat gac ata  cat ctg aca ggg gag  att ttc       14047
Tyr Ile Phe  Ile Thr Asp Asp Ile  His Leu Thr Gly Glu  Ile Phe            
        4065                 4070                 4075                    

tca ttt ttc  aga agt ttc ggc cac  ccc aga ctt gaa gca  gta acg       14092
Ser Phe Phe  Arg Ser Phe Gly His  Pro Arg Leu Glu Ala  Val Thr            
        4080                 4085                 4090                    

gct gct gaa  aat gtt agg aaa tac  atg aat cag cct aaa  gtc att       14137
Ala Ala Glu  Asn Val Arg Lys Tyr  Met Asn Gln Pro Lys  Val Ile            
        4095                 4100                 4105                    

gtg tat gag  act ctg atg aaa ggt  cat gcc ata ttt tgt  gga atc       14182
Val Tyr Glu  Thr Leu Met Lys Gly  His Ala Ile Phe Cys  Gly Ile            
        4110                 4115                 4120                    

ata atc aac  ggc tat cgt gac agg  cac gga ggc agt tgg  cca ccg       14227
Ile Ile Asn  Gly Tyr Arg Asp Arg  His Gly Gly Ser Trp  Pro Pro            
        4125                 4130                 4135                    

ctg acc ctc  ccc ctg cat gct gca  gac aca atc cgg aat  gct caa       14272
Leu Thr Leu  Pro Leu His Ala Ala  Asp Thr Ile Arg Asn  Ala Gln            
        4140                 4145                 4150                    

gct tca ggt  gaa ggg tta aca cat  gag cag tgc gtt gat  aac tgg       14317
Ala Ser Gly  Glu Gly Leu Thr His  Glu Gln Cys Val Asp  Asn Trp            
        4155                 4160                 4165                    

aaa tct ttt  gct gga gtg aaa ttt  ggc tgc ttt atg cct  ctt agc       14362
Lys Ser Phe  Ala Gly Val Lys Phe  Gly Cys Phe Met Pro  Leu Ser            
        4170                 4175                 4180                    

ctg gat agt  gat ctg aca atg tac  cta aag gac aag gca  ctt gct       14407
Leu Asp Ser  Asp Leu Thr Met Tyr  Leu Lys Asp Lys Ala  Leu Ala            
        4185                 4190                 4195                    

gct ctc caa  agg gaa tgg gat tca  gtt tac ccg aaa gag  ttc ctg       14452
Ala Leu Gln  Arg Glu Trp Asp Ser  Val Tyr Pro Lys Glu  Phe Leu            
        4200                 4205                 4210                    

cgt tac gac  cct ccc aag gga acc  ggg tca cgg agg ctt  gta gat       14497
Arg Tyr Asp  Pro Pro Lys Gly Thr  Gly Ser Arg Arg Leu  Val Asp            
        4215                 4220                 4225                    

gtt ttc ctt  aat gat tcg agc ttt  gac cca tat gat gtg  ata atg       14542
Val Phe Leu  Asn Asp Ser Ser Phe  Asp Pro Tyr Asp Val  Ile Met            
        4230                 4235                 4240                    

tat gtt gta  agt gga gct tac ctc  cat gac cct gag ttc  aac ctg       14587
Tyr Val Val  Ser Gly Ala Tyr Leu  His Asp Pro Glu Phe  Asn Leu            
        4245                 4250                 4255                    

tct tac agc  ctg aaa gaa aag gag  atc aag gaa aca ggt  aga ctt       14632
Ser Tyr Ser  Leu Lys Glu Lys Glu  Ile Lys Glu Thr Gly  Arg Leu            
        4260                 4265                 4270                    

ttt gct aaa  atg act tac aaa atg  agg gca tgc caa gtg  att gct       14677
Phe Ala Lys  Met Thr Tyr Lys Met  Arg Ala Cys Gln Val  Ile Ala            
        4275                 4280                 4285                    

gaa aat cta  atc tca aac ggg att  ggc aaa tat ttt aag  gac aat       14722
Glu Asn Leu  Ile Ser Asn Gly Ile  Gly Lys Tyr Phe Lys  Asp Asn            
        4290                 4295                 4300                    

ggg atg gcc  aag gat gag cac gat  ttg act aag gca ctc  cac act       14767
Gly Met Ala  Lys Asp Glu His Asp  Leu Thr Lys Ala Leu  His Thr            
        4305                 4310                 4315                    

cta gct gtc  tca gga gtc ccc aaa  gat ctc aaa gaa agt  cac agg       14812
Leu Ala Val  Ser Gly Val Pro Lys  Asp Leu Lys Glu Ser  His Arg            
        4320                 4325                 4330                    

ggg ggg cca  gtc tta aaa acc tac  tcc cga agc cca gtc  cac aca       14857
Gly Gly Pro  Val Leu Lys Thr Tyr  Ser Arg Ser Pro Val  His Thr            
        4335                 4340                 4345                    

agt acc agg  aac gtg aga gca gca  aaa ggg ttt ata ggg  ttc cct       14902
Ser Thr Arg  Asn Val Arg Ala Ala  Lys Gly Phe Ile Gly  Phe Pro            
        4350                 4355                 4360                    

caa gta att  cgg cag gac caa gac  act gat cat ccg gag  aat atg       14947
Gln Val Ile  Arg Gln Asp Gln Asp  Thr Asp His Pro Glu  Asn Met            
        4365                 4370                 4375                    

gaa gct tac  gag aca gtc agt gca  ttt atc acg act gat  ctc aag       14992
Glu Ala Tyr  Glu Thr Val Ser Ala  Phe Ile Thr Thr Asp  Leu Lys            
        4380                 4385                 4390                    

aag tac tgc  ctt aat tgg aga tat  gag acc atc agc ttg  ttt gca       15037
Lys Tyr Cys  Leu Asn Trp Arg Tyr  Glu Thr Ile Ser Leu  Phe Ala            
        4395                 4400                 4405                    

cag agg cta  aat gag att tac gga  ttg ccc tca ttt ttc  cag tgg       15082
Gln Arg Leu  Asn Glu Ile Tyr Gly  Leu Pro Ser Phe Phe  Gln Trp            
        4410                 4415                 4420                    

ctg cat aag  agg ctt gag acc tct  gtc ctg tat gta agt  gac cct       15127
Leu His Lys  Arg Leu Glu Thr Ser  Val Leu Tyr Val Ser  Asp Pro            
        4425                 4430                 4435                    

cat tgc ccc  ccc gac ctt gac gcc  cat atc ccg tta tat  aaa gtc       15172
His Cys Pro  Pro Asp Leu Asp Ala  His Ile Pro Leu Tyr  Lys Val            
        4440                 4445                 4450                    

ccc aat gat  caa atc ttc att aag  tac cct atg gga ggt  ata gaa       15217
Pro Asn Asp  Gln Ile Phe Ile Lys  Tyr Pro Met Gly Gly  Ile Glu            
        4455                 4460                 4465                    

ggg tat tgt  cag aag ctg tgg acc  atc agc acc att ccc  tat cta       15262
Gly Tyr Cys  Gln Lys Leu Trp Thr  Ile Ser Thr Ile Pro  Tyr Leu            
        4470                 4475                 4480                    

tac ctg gct  gct tat gag agc gga  gta agg att gct tcg  tta gtg       15307
Tyr Leu Ala  Ala Tyr Glu Ser Gly  Val Arg Ile Ala Ser  Leu Val            
        4485                 4490                 4495                    

caa ggg gac  aat cag acc ata gcc  gta aca aaa agg gta  ccc agc       15352
Gln Gly Asp  Asn Gln Thr Ile Ala  Val Thr Lys Arg Val  Pro Ser            
        4500                 4505                 4510                    

aca tgg ccc  tac aac ctt aag aaa  cgg gaa gct gct aga  gta act       15397
Thr Trp Pro  Tyr Asn Leu Lys Lys  Arg Glu Ala Ala Arg  Val Thr            
        4515                 4520                 4525                    

aga gat tac  ttt gta att ctt agg  caa agg cta cat gat  att ggc       15442
Arg Asp Tyr  Phe Val Ile Leu Arg  Gln Arg Leu His Asp  Ile Gly            
        4530                 4535                 4540                    

cat cac ctc  aag gca aat gag aca  att gtt tca tca cat  ttt ttt       15487
His His Leu  Lys Ala Asn Glu Thr  Ile Val Ser Ser His  Phe Phe            
        4545                 4550                 4555                    

gtc tat tca  aaa gga ata tat tat  gat ggg cta ctt gtg  tcc caa       15532
Val Tyr Ser  Lys Gly Ile Tyr Tyr  Asp Gly Leu Leu Val  Ser Gln            
        4560                 4565                 4570                    

tca ctc aag  agc atc gca aga tgt  gta ttc tgg tca gag  act ata       15577
Ser Leu Lys  Ser Ile Ala Arg Cys  Val Phe Trp Ser Glu  Thr Ile            
        4575                 4580                 4585                    

gtt gat gaa  aca agg gca gca tgc  agt aat att gct aca  aca atg       15622
Val Asp Glu  Thr Arg Ala Ala Cys  Ser Asn Ile Ala Thr  Thr Met            
        4590                 4595                 4600                    

gct aaa agc  atc gag aga ggt tat  gac cgt tac ctt gca  tat tcc       15667
Ala Lys Ser  Ile Glu Arg Gly Tyr  Asp Arg Tyr Leu Ala  Tyr Ser            
        4605                 4610                 4615                    

ctg aac gtc  cta aaa gtg ata cag  caa att ctg atc tct  ctt ggc       15712
Leu Asn Val  Leu Lys Val Ile Gln  Gln Ile Leu Ile Ser  Leu Gly            
        4620                 4625                 4630                    

ttc aca atc  aat tca acc atg acc  cgg gat gta gtc ata  ccc ctc       15757
Phe Thr Ile  Asn Ser Thr Met Thr  Arg Asp Val Val Ile  Pro Leu            
        4635                 4640                 4645                    

ctc aca aac  aac gac ctc tta ata  agg atg gca ctg ttg  ccc gct       15802
Leu Thr Asn  Asn Asp Leu Leu Ile  Arg Met Ala Leu Leu  Pro Ala            
        4650                 4655                 4660                    

cct att ggg  ggg atg aat tat ctg  aat atg agc agg ctg  ttt gtc       15847
Pro Ile Gly  Gly Met Asn Tyr Leu  Asn Met Ser Arg Leu  Phe Val            
        4665                 4670                 4675                    

aga aac atc  ggt gat cca gta aca  tca tca att gct gat  ctc aag       15892
Arg Asn Ile  Gly Asp Pro Val Thr  Ser Ser Ile Ala Asp  Leu Lys            
        4680                 4685                 4690                    

aga atg att  ctc gcc tca cta atg  cct gaa gag acc ctc  cat caa       15937
Arg Met Ile  Leu Ala Ser Leu Met  Pro Glu Glu Thr Leu  His Gln            
        4695                 4700                 4705                    

gta atg aca  caa caa ccg ggg gac  tct tca ttc cta gac  tgg gct       15982
Val Met Thr  Gln Gln Pro Gly Asp  Ser Ser Phe Leu Asp  Trp Ala            
        4710                 4715                 4720                    

agc gac cct  tac tca gca aat ctt  gta tgt gtc cag agc  atc act       16027
Ser Asp Pro  Tyr Ser Ala Asn Leu  Val Cys Val Gln Ser  Ile Thr            
        4725                 4730                 4735                    

aga ctc ctc  aag aac ata act gca  agg ttt gtc ctg atc  cat agt       16072
Arg Leu Leu  Lys Asn Ile Thr Ala  Arg Phe Val Leu Ile  His Ser            
        4740                 4745                 4750                    

cca aac cca  atg tta aaa gga tta  ttc cat gat gac agt  aaa gaa       16117
Pro Asn Pro  Met Leu Lys Gly Leu  Phe His Asp Asp Ser  Lys Glu            
        4755                 4760                 4765                    

gag gac gag  gga ctg gcg gca ttc  ctc atg gac agg cat  att ata       16162
Glu Asp Glu  Gly Leu Ala Ala Phe  Leu Met Asp Arg His  Ile Ile            
        4770                 4775                 4780                    

gta cct agg  gca gct cat gaa atc  ctg gat cat agt gtc  aca ggg       16207
Val Pro Arg  Ala Ala His Glu Ile  Leu Asp His Ser Val  Thr Gly            
        4785                 4790                 4795                    

gca aga gag  tct att gca ggc atg  ctg gat acc aca aaa  ggc ttg       16252
Ala Arg Glu  Ser Ile Ala Gly Met  Leu Asp Thr Thr Lys  Gly Leu            
        4800                 4805                 4810                    

att cga gcc  agc atg agg aag ggg  ggg tta acc tct cga  gtg ata       16297
Ile Arg Ala  Ser Met Arg Lys Gly  Gly Leu Thr Ser Arg  Val Ile            
        4815                 4820                 4825                    

acc aga ttg  tcc aat tat gac tat  gaa caa ttc aga gca  ggg atg       16342
Thr Arg Leu  Ser Asn Tyr Asp Tyr  Glu Gln Phe Arg Ala  Gly Met            
        4830                 4835                 4840                    

gtg cta ttg  aca gga aga aag aga  aat gtc ctc att gac  aaa gag       16387
Val Leu Leu  Thr Gly Arg Lys Arg  Asn Val Leu Ile Asp  Lys Glu            
        4845                 4850                 4855                    

tca tgt tca  gtg cag ctg gcg aga  gct cta aga agc cat  atg tgg       16432
Ser Cys Ser  Val Gln Leu Ala Arg  Ala Leu Arg Ser His  Met Trp            
        4860                 4865                 4870                    

gcg agg cta  gct cga gga cgg cct  att tac ggc ctt gag  gtc cct       16477
Ala Arg Leu  Ala Arg Gly Arg Pro  Ile Tyr Gly Leu Glu  Val Pro            
        4875                 4880                 4885                    

gat gta cta  gaa tct atg cga ggc  cac ctt att cgg cgt  cat gag       16522
Asp Val Leu  Glu Ser Met Arg Gly  His Leu Ile Arg Arg  His Glu            
        4890                 4895                 4900                    

aca tgt gtc  atc tgc gag tgt gga  tca gtc aac tac gga  tgg ttt       16567
Thr Cys Val  Ile Cys Glu Cys Gly  Ser Val Asn Tyr Gly  Trp Phe            
        4905                 4910                 4915                    

ttt gtc ccc  tcg ggt tgc caa ctg  gat gat att gac aag  gaa aca       16612
Phe Val Pro  Ser Gly Cys Gln Leu  Asp Asp Ile Asp Lys  Glu Thr            
        4920                 4925                 4930                    

tca tcc ttg  aga gtc cca tat att  ggt tct acc act gat  gag aga       16657
Ser Ser Leu  Arg Val Pro Tyr Ile  Gly Ser Thr Thr Asp  Glu Arg            
        4935                 4940                 4945                    

aca gac atg  aag ctt gcc ttc gta  aga gcc cca agt cga  tcc ttg       16702
Thr Asp Met  Lys Leu Ala Phe Val  Arg Ala Pro Ser Arg  Ser Leu            
        4950                 4955                 4960                    

cga tct gct  gtt aga ata gca aca  gtg tac tca tgg gct  tac ggt       16747
Arg Ser Ala  Val Arg Ile Ala Thr  Val Tyr Ser Trp Ala  Tyr Gly            
        4965                 4970                 4975                    

gat gat gat  agc tct tgg aac gaa  gcc tgg ttg ttg gct  agg caa       16792
Asp Asp Asp  Ser Ser Trp Asn Glu  Ala Trp Leu Leu Ala  Arg Gln            
        4980                 4985                 4990                    

agg gcc aat  gtg agc ctg gag gag  cta agg gtg atc act  ccc atc       16837
Arg Ala Asn  Val Ser Leu Glu Glu  Leu Arg Val Ile Thr  Pro Ile            
        4995                 5000                 5005                    

tca act tcg  act aat tta gcg cat  agg ttg agg gat cgt  agc act       16882
Ser Thr Ser  Thr Asn Leu Ala His  Arg Leu Arg Asp Arg  Ser Thr            
        5010                 5015                 5020                    

caa gtg aaa  tac tca ggt aca tcc  ctt gtc cga gtg gcg  agg tat       16927
Gln Val Lys  Tyr Ser Gly Thr Ser  Leu Val Arg Val Ala  Arg Tyr            
        5025                 5030                 5035                    

acc aca atc  tcc aac gac aat ctc  tca ttt gtc ata tca  gat aag       16972
Thr Thr Ile  Ser Asn Asp Asn Leu  Ser Phe Val Ile Ser  Asp Lys            
        5040                 5045                 5050                    

aag gtt gat  act aac ttt ata tac  caa caa gga atg ctt  cta ggg       17017
Lys Val Asp  Thr Asn Phe Ile Tyr  Gln Gln Gly Met Leu  Leu Gly            
        5055                 5060                 5065                    

ttg ggt gtt  tta gaa aca ttg ttt  cga ctc gag aaa gat  acc gga       17062
Leu Gly Val  Leu Glu Thr Leu Phe  Arg Leu Glu Lys Asp  Thr Gly            
        5070                 5075                 5080                    

tca tct aac  acg gta tta cat ctt  cac gtc gaa aca gat  tgt tgc       17107
Ser Ser Asn  Thr Val Leu His Leu  His Val Glu Thr Asp  Cys Cys            
        5085                 5090                 5095                    

gtg atc ccg  atg ata gat cat ccc  agg ata ccc agc tcc  cgc aag       17152
Val Ile Pro  Met Ile Asp His Pro  Arg Ile Pro Ser Ser  Arg Lys            
        5100                 5105                 5110                    

cta gag ctg  agg gca gag cta tgt  acc aac cca ttg ata  tat gat       17197
Leu Glu Leu  Arg Ala Glu Leu Cys  Thr Asn Pro Leu Ile  Tyr Asp            
        5115                 5120                 5125                    

aat gca cct  tta att gac aga gat  gca aca agg cta tac  acc cag       17242
Asn Ala Pro  Leu Ile Asp Arg Asp  Ala Thr Arg Leu Tyr  Thr Gln            
        5130                 5135                 5140                    

agc cat agg  agg cac ctt gtg gaa  ttt gtt aca tgg tcc  aca ccc       17287
Ser His Arg  Arg His Leu Val Glu  Phe Val Thr Trp Ser  Thr Pro            
        5145                 5150                 5155                    

caa cta tat  cac att tta gct aag  tcc aca gca cta tct  atg att       17332
Gln Leu Tyr  His Ile Leu Ala Lys  Ser Thr Ala Leu Ser  Met Ile            
        5160                 5165                 5170                    

gac ctg gta  aca aaa ttt gag aag  gac cat atg aat gaa  att tca       17377
Asp Leu Val  Thr Lys Phe Glu Lys  Asp His Met Asn Glu  Ile Ser            
        5175                 5180                 5185                    

gct ctc ata  ggg gat gac gat atc  aat agt ttc ata act  gag ttt       17422
Ala Leu Ile  Gly Asp Asp Asp Ile  Asn Ser Phe Ile Thr  Glu Phe            
        5190                 5195                 5200                    

ctg ctc ata  gag cca aga tta ttc  act atc tac ttg ggc  cag tgt       17467
Leu Leu Ile  Glu Pro Arg Leu Phe  Thr Ile Tyr Leu Gly  Gln Cys            
        5205                 5210                 5215                    

gcg gcc atc  aat tgg gca ttt gat  gta cat tat cat aga  cca tca       17512
Ala Ala Ile  Asn Trp Ala Phe Asp  Val His Tyr His Arg  Pro Ser            
        5220                 5225                 5230                    

ggg aaa tat  cag atg ggt gag ctg  ttg tca tcg ttc ctt  tct aga       17557
Gly Lys Tyr  Gln Met Gly Glu Leu  Leu Ser Ser Phe Leu  Ser Arg            
        5235                 5240                 5245                    

atg agc aaa  gga gtg ttt aag gtg  ctt gtc aat gct cta  agc cac       17602
Met Ser Lys  Gly Val Phe Lys Val  Leu Val Asn Ala Leu  Ser His            
        5250                 5255                 5260                    

cca aag atc  tac aag aaa ttc tgg  cat tgt ggt att ata  gag cct       17647
Pro Lys Ile  Tyr Lys Lys Phe Trp  His Cys Gly Ile Ile  Glu Pro            
        5265                 5270                 5275                    

atc cat ggt  cct tca ctt gat gct  caa aac ttg cac aca  act gtg       17692
Ile His Gly  Pro Ser Leu Asp Ala  Gln Asn Leu His Thr  Thr Val            
        5280                 5285                 5290                    

tgc aac atg  gtt tac aca tgc tat  atg acc tac ctc gac  ctg ttg       17737
Cys Asn Met  Val Tyr Thr Cys Tyr  Met Thr Tyr Leu Asp  Leu Leu            
        5295                 5300                 5305                    

ttg aat gaa  gag tta gaa gag ttc  aca ttt ctc ttg tgt  gaa agc       17782
Leu Asn Glu  Glu Leu Glu Glu Phe  Thr Phe Leu Leu Cys  Glu Ser            
        5310                 5315                 5320                    

gac gag gat  gta gta ccg gac aga  ttc gac aac atc cag  gca aaa       17827
Asp Glu Asp  Val Val Pro Asp Arg  Phe Asp Asn Ile Gln  Ala Lys            
        5325                 5330                 5335                    

cac tta tgt  gtt ctg gca gat ttg  tac tgt caa cca ggg  acc tgc       17872
His Leu Cys  Val Leu Ala Asp Leu  Tyr Cys Gln Pro Gly  Thr Cys            
        5340                 5345                 5350                    

cca cca att  cga ggt cta aga ccg  gta gag aaa tgt gca  gtt cta       17917
Pro Pro Ile  Arg Gly Leu Arg Pro  Val Glu Lys Cys Ala  Val Leu            
        5355                 5360                 5365                    

acc gac cat  atc aag gca gag gct  atg tta tct cca gca  gga tct       17962
Thr Asp His  Ile Lys Ala Glu Ala  Met Leu Ser Pro Ala  Gly Ser            
        5370                 5375                 5380                    

tcg tgg aac  ata aat cca att att  gta gac cat tac tca  tgc tct       18007
Ser Trp Asn  Ile Asn Pro Ile Ile  Val Asp His Tyr Ser  Cys Ser            
        5385                 5390                 5395                    

ctg act tat  ctc cgg cga gga tcg  atc aaa cag ata aga  ttg aga       18052
Leu Thr Tyr  Leu Arg Arg Gly Ser  Ile Lys Gln Ile Arg  Leu Arg            
        5400                 5405                 5410                    

gtt gat cca  gga ttc att ttc gac  gcc ctc gct gag gta  aat gtc       18097
Val Asp Pro  Gly Phe Ile Phe Asp  Ala Leu Ala Glu Val  Asn Val            
        5415                 5420                 5425                    

agt cag cca  aag atc ggc agc aac  aac atc tca aat atg  agc atc       18142
Ser Gln Pro  Lys Ile Gly Ser Asn  Asn Ile Ser Asn Met  Ser Ile            
        5430                 5435                 5440                    

aag gct ttc  aga ccc cca cac gat  gat gtt gca aaa ttg  ctc aaa       18187
Lys Ala Phe  Arg Pro Pro His Asp  Asp Val Ala Lys Leu  Leu Lys            
        5445                 5450                 5455                    

gat atc aac  aca agc aag cac aat  ctt ccc att tca ggg  ggc aat       18232
Asp Ile Asn  Thr Ser Lys His Asn  Leu Pro Ile Ser Gly  Gly Asn            
        5460                 5465                 5470                    

ctc gcc aat  tat gaa atc cat gct  ttc cgc aga atc ggg  ttg aac       18277
Leu Ala Asn  Tyr Glu Ile His Ala  Phe Arg Arg Ile Gly  Leu Asn            
        5475                 5480                 5485                    

tca tct gct  tgc tac aaa gct gtt  gag ata tca aca tta  att agg       18322
Ser Ser Ala  Cys Tyr Lys Ala Val  Glu Ile Ser Thr Leu  Ile Arg            
        5490                 5495                 5500                    

aga tgc ctt  gag cca ggg gag gac  ggc ttg ttc ttg ggt  gag gga       18367
Arg Cys Leu  Glu Pro Gly Glu Asp  Gly Leu Phe Leu Gly  Glu Gly            
        5505                 5510                 5515                    

tcg ggt tct  atg ttg atc act tat  aaa gag ata ctt aaa  cta aac       18412
Ser Gly Ser  Met Leu Ile Thr Tyr  Lys Glu Ile Leu Lys  Leu Asn            
        5520                 5525                 5530                    

aag tgc ttc  tat aat agt ggg gtt  tcc gcc aat tct aga  tct ggt       18457
Lys Cys Phe  Tyr Asn Ser Gly Val  Ser Ala Asn Ser Arg  Ser Gly            
        5535                 5540                 5545                    

caa agg gaa  tta gca ccc tat ccc  tcc gaa gtt ggc ctt  gtc gaa       18502
Gln Arg Glu  Leu Ala Pro Tyr Pro  Ser Glu Val Gly Leu  Val Glu            
        5550                 5555                 5560                    

cac aga atg  gga gta ggt aat att  gtc aaa gtg ctc ttt  aac ggg       18547
His Arg Met  Gly Val Gly Asn Ile  Val Lys Val Leu Phe  Asn Gly            
        5565                 5570                 5575                    

agg ccc gaa  gtc acg tgg gta ggc  agt gta gat tgc ttc  aat ttc       18592
Arg Pro Glu  Val Thr Trp Val Gly  Ser Val Asp Cys Phe  Asn Phe            
        5580                 5585                 5590                    

ata gtt agt  aat atc cct acc tct  agt gtg ggg ttt atc  cat tca       18637
Ile Val Ser  Asn Ile Pro Thr Ser  Ser Val Gly Phe Ile  His Ser            
        5595                 5600                 5605                    

gat ata gag  acc ttg cct gac aaa  gat act ata gag aag  cta gag       18682
Asp Ile Glu  Thr Leu Pro Asp Lys  Asp Thr Ile Glu Lys  Leu Glu            
        5610                 5615                 5620                    

gaa ttg gca  gcc atc tta tcg atg  gct ctg ctc ctg ggc  aaa ata       18727
Glu Leu Ala  Ala Ile Leu Ser Met  Ala Leu Leu Leu Gly  Lys Ile            
        5625                 5630                 5635                    

gga tca ata  ctg gtg att aag ctt  atg cct ttc agc ggg  gat ttt       18772
Gly Ser Ile  Leu Val Ile Lys Leu  Met Pro Phe Ser Gly  Asp Phe            
        5640                 5645                 5650                    

gtt cag gga  ttt ata agt tat gta  ggg tct cat tat aga  gaa gtg       18817
Val Gln Gly  Phe Ile Ser Tyr Val  Gly Ser His Tyr Arg  Glu Val            
        5655                 5660                 5665                    

aac ctt gta  tac cct aga tac agc  aac ttc atc tct act  gaa tct       18862
Asn Leu Val  Tyr Pro Arg Tyr Ser  Asn Phe Ile Ser Thr  Glu Ser            
        5670                 5675                 5680                    

tat ttg gtt  atg aca gat ctc aag  gct aac cgg cta atg  aat cct       18907
Tyr Leu Val  Met Thr Asp Leu Lys  Ala Asn Arg Leu Met  Asn Pro            
        5685                 5690                 5695                    

gaa aag att  aag cag cag ata att  gaa tca tct gtg agg  act tca       18952
Glu Lys Ile  Lys Gln Gln Ile Ile  Glu Ser Ser Val Arg  Thr Ser            
        5700                 5705                 5710                    

cct gga ctt  ata ggt cac atc cta  tcc att aag caa cta  agc tgc       18997
Pro Gly Leu  Ile Gly His Ile Leu  Ser Ile Lys Gln Leu  Ser Cys            
        5715                 5720                 5725                    

ata caa gca  att gtg gga gac gca  gtt agt aga ggt gat  atc aat       19042
Ile Gln Ala  Ile Val Gly Asp Ala  Val Ser Arg Gly Asp  Ile Asn            
        5730                 5735                 5740                    

cct act ctg  aaa aaa ctt aca cct  ata gag cag gtg ctg  atc aat       19087
Pro Thr Leu  Lys Lys Leu Thr Pro  Ile Glu Gln Val Leu  Ile Asn            
        5745                 5750                 5755                    

tgc ggg ttg  gca att aac gga cct  aag ctg tgc aaa gaa  ttg atc       19132
Cys Gly Leu  Ala Ile Asn Gly Pro  Lys Leu Cys Lys Glu  Leu Ile            
        5760                 5765                 5770                    

cac cat gat  gtt gcc tca ggg caa  gat gga ttg ctt aat  tct ata       19177
His His Asp  Val Ala Ser Gly Gln  Asp Gly Leu Leu Asn  Ser Ile            
        5775                 5780                 5785                    

ctc atc ctc  tac agg gag ttg gca  aga ttc aaa gac aac  caa aga       19222
Leu Ile Leu  Tyr Arg Glu Leu Ala  Arg Phe Lys Asp Asn  Gln Arg            
        5790                 5795                 5800                    

agt caa caa  ggg atg ttc cac gct  tac ccc gta ttg gta  agt agc       19267
Ser Gln Gln  Gly Met Phe His Ala  Tyr Pro Val Leu Val  Ser Ser            
        5805                 5810                 5815                    

agg caa cga  gaa ctt ata tct agg  atc acc cgc aaa ttc  tgg ggg       19312
Arg Gln Arg  Glu Leu Ile Ser Arg  Ile Thr Arg Lys Phe  Trp Gly            
        5820                 5825                 5830                    

cac att ctt  ctt tac tcc ggg aac  aaa aag ttg ata aat  aag ttt       19357
His Ile Leu  Leu Tyr Ser Gly Asn  Lys Lys Leu Ile Asn  Lys Phe            
        5835                 5840                 5845                    

atc cag aat  ctc aag tcc ggc tat  ctg ata cta gac tta  cac cag       19402
Ile Gln Asn  Leu Lys Ser Gly Tyr  Leu Ile Leu Asp Leu  His Gln            
        5850                 5855                 5860                    

aat atc ttc  gtt aag aat cta tcc  aag tca gag aaa cag  att att       19447
Asn Ile Phe  Val Lys Asn Leu Ser  Lys Ser Glu Lys Gln  Ile Ile            
        5865                 5870                 5875                    

atg acg ggg  ggt ttg aaa cgt gag  tgg gtt ttt aag gta  aca gtc       19492
Met Thr Gly  Gly Leu Lys Arg Glu  Trp Val Phe Lys Val  Thr Val            
        5880                 5885                 5890                    

aag gag acc  aaa gaa tgg tat aag  tta gtc gga tac agt  gcc ctg       19537
Lys Glu Thr  Lys Glu Trp Tyr Lys  Leu Val Gly Tyr Ser  Ala Leu            
        5895                 5900                 5905                    

att aag gac  taa ttggttgaac tccggaaccc taatcctgcc ctaggtggtt         19589
Ile Lys Asp                                                               
        5910                                                              

aggcattatt tgcaatatat taaagaaaac tttgaaaata cgaagtttct attcccagct    19649

ttgtctggtg gccggcatgg tcccagcctc ctcgctggcg ccggctgggc aacattccga    19709

ggggaccgtc ccctcggtaa tggcgaatgg gacgcggccg atccggctgc taacaaagcc    19769

cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata accccttggg    19829

gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc cggatgcggc    19889

cgcgggccct atggtaccca gcttttgttc cctttagtga gggttaattc cgagcttggc    19949

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa    20009

cataggagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga ggtaactcac    20069

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca    20129

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc    20189

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc    20249

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc    20309

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag    20369

gctcggcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc    20429

gacaggacta taaagatacc aggcgttccc ccctggaagc tccctcgtgc gctctcctgt    20489

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct    20549

ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg    20609

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct    20669

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat    20729

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg    20789

ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa    20849

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt    20909

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc    20969

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt    21029

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta    21089

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat    21149

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctgcccgtcg tgtagataac    21209

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg    21269

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag    21329

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt    21389

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt    21449

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt    21509

tacatgatcc cccatgttgt gaaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt    21569

cagaagtaag ttggccgcag tgttatcact catgcttatg gcagcactgc ataattctct    21629

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt    21689

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac    21749

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa    21809

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa    21869

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca    21929

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct    21989

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga    22049

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc    22109

tgaaattgta aacgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc    22169

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    22229

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    22289

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    22349

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    22409

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    22469

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    22529

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    22589

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc caccgcggtg    22649


<210>  4
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Ala Thr Leu Leu Arg Ser Leu Ala Leu Phe Lys Arg Asn Lys Asp 
1               5                   10                  15      


Lys Pro Pro Ile Thr Ser Gly Ser Gly Gly Ala Ile Arg Gly Ile Lys 
            20                  25                  30          


His Ile Ile Ile Val Pro Ile Pro Gly Asp Ser Ser Ile Thr Thr Arg 
        35                  40                  45              


Ser Arg Leu Leu Asp Arg Leu Val Arg Leu Ile Gly Asn Pro Asp Val 
    50                  55                  60                  


Ser Gly Pro Lys Leu Thr Gly Ala Leu Ile Gly Ile Leu Ser Leu Phe 
65                  70                  75                  80  


Val Glu Ser Pro Gly Gln Leu Ile Gln Arg Ile Thr Asp Asp Pro Asp 
                85                  90                  95      


Val Ser Ile Arg Leu Leu Glu Val Val Gln Ser Asp Gln Ser Gln Ser 
            100                 105                 110         


Gly Leu Thr Phe Ala Ser Arg Gly Thr Asn Met Glu Asp Glu Ala Asp 
        115                 120                 125             


Gln Tyr Phe Ser His Asp Asp Pro Ile Ser Ser Asp Gln Ser Arg Phe 
    130                 135                 140                 


Gly Trp Phe Gly Asn Lys Glu Ile Ser Asp Ile Glu Val Gln Asp Pro 
145                 150                 155                 160 


Glu Gly Phe Asn Met Ile Leu Gly Thr Ile Leu Ala Gln Ile Trp Val 
                165                 170                 175     


Leu Leu Ala Lys Ala Val Thr Ala Pro Asp Thr Ala Ala Asp Ser Glu 
            180                 185                 190         


Leu Arg Arg Trp Ile Lys Tyr Thr Gln Gln Arg Arg Val Val Gly Glu 
        195                 200                 205             


Phe Arg Leu Glu Arg Lys Trp Leu Asp Val Val Arg Asn Arg Ile Ala 
    210                 215                 220                 


Glu Asp Leu Ser Leu Arg Arg Phe Met Val Ala Leu Ile Leu Asp Ile 
225                 230                 235                 240 


Lys Arg Thr Pro Gly Asn Lys Pro Arg Ile Ala Glu Met Ile Cys Asp 
                245                 250                 255     


Ile Asp Thr Tyr Ile Val Glu Ala Gly Leu Ala Ser Phe Ile Leu Thr 
            260                 265                 270         


Ile Lys Phe Gly Ile Glu Thr Met Tyr Pro Ala Leu Gly Leu His Glu 
        275                 280                 285             


Phe Ala Gly Glu Leu Ser Thr Leu Glu Ser Leu Met Asn Leu Tyr Gln 
    290                 295                 300                 


Gln Met Gly Glu Thr Ala Pro Tyr Met Val Ile Leu Glu Asn Ser Ile 
305                 310                 315                 320 


Gln Asn Lys Phe Ser Ala Gly Ser Tyr Pro Leu Leu Trp Ser Tyr Ala 
                325                 330                 335     


Met Gly Val Gly Val Glu Leu Glu Asn Ser Met Gly Gly Leu Asn Phe 
            340                 345                 350         


Gly Arg Ser Tyr Phe Asp Pro Ala Tyr Phe Arg Leu Gly Gln Glu Met 
        355                 360                 365             


Val Arg Arg Ser Ala Gly Lys Val Ser Ser Thr Leu Ala Ser Glu Leu 
    370                 375                 380                 


Gly Ile Thr Ala Glu Asp Ala Arg Leu Val Ser Glu Ile Ala Met His 
385                 390                 395                 400 


Thr Thr Glu Asp Lys Ile Ser Arg Ala Val Gly Pro Arg Gln Ala Gln 
                405                 410                 415     


Val Ser Phe Leu His Gly Asp Gln Ser Glu Asn Glu Leu Pro Arg Leu 
            420                 425                 430         


Gly Gly Lys Glu Asp Arg Arg Val Lys Gln Ser Arg Gly Glu Ala Arg 
        435                 440                 445             


Glu Ser Tyr Arg Glu Thr Gly Pro Ser Arg Ala Ser Asp Ala Arg Ala 
    450                 455                 460                 


Ala His Leu Pro Thr Gly Thr Pro Leu Asp Ile Asp Thr Ala Thr Glu 
465                 470                 475                 480 


Ser Ser Gln Asp Pro Gln Asp Ser Arg Arg Ser Ala Asp Ala Leu Leu 
                485                 490                 495     


Arg Leu Gln Ala Met Ala Gly Ile Ser Glu Glu Gln Gly Ser Asp Thr 
            500                 505                 510         


Asp Thr Pro Ile Val Tyr Asn Asp Arg Asn Leu Leu Asp 
        515                 520                 525 


<210>  5
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Ala Glu Glu Gln Ala Arg His Val Lys Asn Gly Leu Glu Cys Ile 
1               5                   10                  15      


Arg Ala Leu Lys Ala Glu Pro Ile Gly Ser Leu Ala Ile Glu Glu Ala 
            20                  25                  30          


Met Ala Ala Trp Ser Glu Ile Ser Asp Asn Pro Gly Gln Glu Arg Ala 
        35                  40                  45              


Thr Cys Arg Glu Glu Lys Ala Gly Ser Ser Gly Leu Ser Lys Pro Cys 
    50                  55                  60                  


Leu Ser Ala Ile Gly Ser Thr Glu Gly Gly Ala Pro Arg Ile Arg Gly 
65                  70                  75                  80  


Gln Gly Pro Gly Glu Ser Asp Asp Asp Ala Glu Thr Leu Gly Ile Pro 
                85                  90                  95      


Pro Arg Asn Leu Gln Ala Ser Ser Thr Gly Leu Gln Cys Tyr Tyr Val 
            100                 105                 110         


Tyr Asp His Ser Gly Glu Ala Val Lys Gly Ile Gln Asp Ala Asp Ser 
        115                 120                 125             


Ile Met Val Gln Ser Gly Leu Asp Gly Asp Ser Thr Leu Ser Gly Gly 
    130                 135                 140                 


Asp Asn Glu Ser Glu Asn Ser Asp Val Asp Ile Gly Glu Pro Asp Thr 
145                 150                 155                 160 


Glu Gly Tyr Ala Ile Thr Asp Arg Gly Ser Ala Pro Ile Ser Met Gly 
                165                 170                 175     


Phe Arg Ala Ser Asp Val Glu Thr Ala Glu Gly Gly Glu Ile His Glu 
            180                 185                 190         


Leu Leu Arg Leu Gln Ser Arg Gly Asn Asn Phe Pro Lys Leu Gly Lys 
        195                 200                 205             


Thr Leu Asn Val Pro Pro Pro Pro Asp Pro Gly Arg Ala Ser Thr Ser 
    210                 215                 220                 


Gly Thr Pro Ile Lys Lys Gly Thr Asp Ala Arg Leu Ala Ser Phe Gly 
225                 230                 235                 240 


Thr Glu Ile Ala Ser Leu Leu Thr Gly Gly Ala Thr Gln Cys Ala Arg 
                245                 250                 255     


Lys Ser Pro Ser Glu Pro Ser Gly Pro Gly Ala Pro Ala Gly Asn Val 
            260                 265                 270         


Pro Glu Cys Val Ser Asn Ala Ala Leu Ile Gln Glu Trp Thr Pro Glu 
        275                 280                 285             


Ser Gly Thr Thr Ile Ser Pro Arg Ser Gln Asn Asn Glu Glu Gly Gly 
    290                 295                 300                 


Asp Tyr Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys Thr 
305                 310                 315                 320 


Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu 
                325                 330                 335     


Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys Gln 
            340                 345                 350         


Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu Ser 
        355                 360                 365             


Ser Ile Met Ile Ala Ile Pro Gly Leu Gly Lys Asp Pro Asn Asp Pro 
    370                 375                 380                 


Thr Ala Asp Val Glu Ile Asn Pro Asp Leu Lys Pro Ile Ile Gly Arg 
385                 390                 395                 400 


Asp Ser Gly Arg Ala Leu Ala Glu Val Leu Lys Lys Pro Val Ala Ser 
                405                 410                 415     


Arg Gln Leu Gln Gly Met Thr Asn Gly Arg Thr Ser Ser Arg Gly Gln 
            420                 425                 430         


Leu Leu Lys Glu Phe Gln Leu Lys Pro Ile Gly Lys Lys Met Ser Ser 
        435                 440                 445             


Ala Val Gly Phe Val Pro Asp Thr Gly Pro Ala Ser Arg Ser Val Ile 
    450                 455                 460                 


Arg Ser Ile Ile Lys Ser Ser Arg Leu Glu Glu Asp Arg Lys Arg Tyr 
465                 470                 475                 480 


Leu Met Thr Leu Leu Asp Asp Ile Lys Gly Ala Asn Asp Leu Ala Lys 
                485                 490                 495     


Phe His Gln Met Leu Met Lys Ile Ile Met Lys 
            500                 505         


<210>  6
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210>  7
<211>  1082
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Arg Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg 
1               5                   10                  15      


Pro Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu 
            20                  25                  30          


Leu Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn 
        35                  40                  45              


Val Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro 
    50                  55                  60                  


Pro Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val 
65                  70                  75                  80  


Thr Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg 
                85                  90                  95      


Val Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe 
            100                 105                 110         


Val Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu 
        115                 120                 125             


Tyr Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser 
    130                 135                 140                 


Gly Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val 
145                 150                 155                 160 


Arg Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg 
                165                 170                 175     


Arg Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg 
            180                 185                 190         


Arg Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser 
        195                 200                 205             


Trp Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys 
    210                 215                 220                 


Val Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly 
225                 230                 235                 240 


Ala Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His 
                245                 250                 255     


His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr 
            260                 265                 270         


Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser 
        275                 280                 285             


Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg 
    290                 295                 300                 


Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly 
305                 310                 315                 320 


Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro 
                325                 330                 335     


Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn 
            340                 345                 350         


His Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu 
        355                 360                 365             


Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro 
    370                 375                 380                 


Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg 
385                 390                 395                 400 


Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly 
                405                 410                 415     


Phe Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly 
            420                 425                 430         


Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile 
        435                 440                 445             


Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys 
    450                 455                 460                 


Met Ser Val Arg Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly 
465                 470                 475                 480 


Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys 
                485                 490                 495     


Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser 
            500                 505                 510         


Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe 
        515                 520                 525             


Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln 
    530                 535                 540                 


His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg 
545                 550                 555                 560 


Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe 
                565                 570                 575     


Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val 
            580                 585                 590         


Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr 
        595                 600                 605             


Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg 
    610                 615                 620                 


Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His 
625                 630                 635                 640 


Arg Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro 
                645                 650                 655     


Pro Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr 
            660                 665                 670         


Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro 
        675                 680                 685             


Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala 
    690                 695                 700                 


His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr 
705                 710                 715                 720 


Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr 
                725                 730                 735     


Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn 
            740                 745                 750         


Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His 
        755                 760                 765             


His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile 
    770                 775                 780                 


Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly 
785                 790                 795                 800 


Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu 
                805                 810                 815     


Leu Arg Leu Phe Leu Leu Val Thr Pro His Leu Thr His Ala Lys Thr 
            820                 825                 830         


Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys Val Val 
        835                 840                 845             


Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu Ala Leu 
    850                 855                 860                 


Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe Pro Trp 
865                 870                 875                 880 


Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser Asp Tyr 
                885                 890                 895     


Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe Asn Arg 
            900                 905                 910         


Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly Val Leu 
        915                 920                 925             


Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn Ser Leu 
    930                 935                 940                 


Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu Gln Ala Tyr 
945                 950                 955                 960 


Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln Gln Val Trp 
                965                 970                 975     


Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr Ala Ser Leu 
            980                 985                 990         


Cys Tyr Ser Ile Leu Lys Ala Lys  Asn Ala Gly Met Ser  Leu Gly Ala 
        995                 1000                 1005             


Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu Ala Val  Gln Trp Leu 
    1010                 1015                 1020             


Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr Arg His  Arg Val Thr 
    1025                 1030                 1035             


Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr Ala Gln  Thr Gln Leu 
    1040                 1045                 1050             


Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr Ala Leu  Glu Ala Ala 
    1055                 1060                 1065             


Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys Thr Ile  Leu Asp 
    1070                 1075                 1080         


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Thr Glu Leu Lys Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser 
1               5                   10                  15      


Leu Thr 
        


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  10
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Thr Glu Thr Tyr Asp Phe Asp Lys Ser Ala Trp Asp Ile Lys Gly 
1               5                   10                  15      


Ser Ile Ala Pro Ile Gln Pro Thr Thr Tyr Ser Asp Gly Arg Leu Val 
            20                  25                  30          


Pro Gln Val Arg Val Ile Asp Pro Gly Leu Gly Asp Arg Lys Asp Glu 
        35                  40                  45              


Cys Phe Met Tyr Met Phe Leu Leu Gly Val Val Glu Asp Ser Asp Ser 
    50                  55                  60                  


Leu Gly Pro Pro Ile Gly Arg Ala Phe Gly Phe Leu Pro Leu Gly Val 
65                  70                  75                  80  


Gly Arg Ser Thr Ala Lys Pro Glu Lys Leu Leu Lys Glu Ala Thr Glu 
                85                  90                  95      


Leu Asp Ile Val Val Arg Arg Thr Ala Gly Leu Asn Glu Lys Leu Val 
            100                 105                 110         


Phe Tyr Asn Asn Thr Pro Leu Thr Leu Leu Thr Pro Trp Arg Lys Val 
        115                 120                 125             


Leu Thr Thr Gly Ser Val Phe Asn Ala Asn Gln Val Cys Asn Ala Val 
    130                 135                 140                 


Asn Leu Ile Pro Leu Asp Thr Pro Gln Arg Phe Arg Val Val Tyr Met 
145                 150                 155                 160 


Ser Ile Thr Arg Leu Ser Asp Asn Gly Tyr Tyr Thr Val Pro Arg Arg 
                165                 170                 175     


Met Leu Glu Phe Arg Ser Val Asn Ala Val Ala Phe Asn Leu Leu Val 
            180                 185                 190         


Thr Leu Arg Ile Asp Lys Ala Ile Gly Pro Gly Lys Ile Ile Asp Asn 
        195                 200                 205             


Thr Glu Gln Leu Pro Glu Ala Thr Phe Met Val His Ile Gly Asn Phe 
    210                 215                 220                 


Arg Arg Lys Lys Ser Glu Val Tyr Ser Ala Asp Tyr Cys Lys Met Lys 
225                 230                 235                 240 


Ile Glu Lys Met Gly Leu Val Phe Ala Leu Gly Gly Ile Gly Gly Thr 
                245                 250                 255     


Ser Leu His Ile Arg Ser Thr Gly Lys Met Ser Lys Thr Leu His Ala 
            260                 265                 270         


Gln Leu Gly Phe Lys Lys Thr Leu Cys Tyr Pro Leu Met Asp Ile Asn 
        275                 280                 285             


Glu Asp Leu Asn Arg Leu Leu Trp Arg Ser Arg Cys Lys Ile Val Arg 
    290                 295                 300                 


Ile Gln Ala Val Leu Gln Pro Ser Val Pro Gln Glu Phe Arg Ile Tyr 
305                 310                 315                 320 


Asp Asp Val Ile Ile Asn Asp Asp Gln Gly Leu Phe Lys Val Leu 
                325                 330                 335 


<210>  11
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Ser Ile Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala 
1               5                   10                  15      


Val Leu Leu Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn 
            20                  25                  30          


Leu Ser Lys Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val 
        35                  40                  45              


Met Thr Arg Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn 
    50                  55                  60                  


Ile Thr Leu Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg 
65                  70                  75                  80  


Arg Leu Leu Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala 
                85                  90                  95      


Met Thr Gln Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg 
            100                 105                 110         


His Lys Arg Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val 
        115                 120                 125             


Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met 
    130                 135                 140                 


Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 
145                 150                 155                 160 


Asn Gln Ala Ile Glu Thr Ile Arg Gln Ala Gly Gln Glu Met Ile Leu 
                165                 170                 175     


Ala Val Gln Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser 
            180                 185                 190         


Met Asn Gln Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys 
        195                 200                 205             


Leu Leu Arg Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu 
    210                 215                 220                 


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
225                 230                 235                 240 


Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly 
                245                 250                 255     


Gly Asp Leu Leu Gly Ile Leu Glu Ser Gly Gly Ile Lys Ala Arg Ile 
            260                 265                 270         


Thr His Val Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr 
        275                 280                 285             


Pro Thr Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly 
    290                 295                 300                 


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys 
305                 310                 315                 320 


Tyr Val Ala Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
                325                 330                 335     


Cys Thr Phe Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr 
            340                 345                 350         


Pro Met Ser Pro Leu Leu Gln Glu Cys Leu Arg Gly Tyr Thr Lys Ser 
        355                 360                 365             


Cys Ala Arg Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu 
    370                 375                 380                 


Ser Gln Gly Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
385                 390                 395                 400 


Tyr Thr Thr Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr 
                405                 410                 415     


Tyr Ile Ala Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr 
            420                 425                 430         


Ile Gln Val Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg 
        435                 440                 445             


Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
    450                 455                 460                 


Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu 
465                 470                 475                 480 


Glu Ser Ser Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr 
                485                 490                 495     


Ser Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly 
            500                 505                 510         


Ile Pro Ala Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly 
        515                 520                 525             


Glu Gln Val Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly 
    530                 535                 540                 


Thr Ser Lys Ser Tyr Val Arg Ser Leu 
545                 550             


<210>  12
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val 
65                  70                  75                  80  


Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Val Lys Leu Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr 
                165                 170                 175     


Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr 
            180                 185                 190         


Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu 
        195                 200                 205             


Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser 
    210                 215                 220                 


Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu 
                245                 250                 255     


Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met 
            260                 265                 270         


Thr Asn Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met 
        275                 280                 285             


Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp 
    290                 295                 300                 


Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln 
305                 310                 315                 320 


Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp 
                325                 330                 335     


Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln 
    370                 375                 380                 


Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala 
385                 390                 395                 400 


Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp 
                405                 410                 415     


Leu Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His 
        435                 440                 445             


Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu 
    450                 455                 460                 


Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro 
465                 470                 475                 480 


Tyr Leu Phe Thr Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala 
                485                 490                 495     


Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr 
        515                 520                 525             


Tyr Asp Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser 
    530                 535                 540                 


Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys 
                565                 570                 575     


Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly 
            580                 585                 590         


His Ile Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val 
        595                 600                 605             


Thr Arg Glu Asp Gly Thr Asn Arg Arg 
    610                 615         


<210>  13
<211>  2183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Asp Ser Leu Ser Val Asn Gln Ile Leu Tyr Pro Glu Val His Leu 
1               5                   10                  15      


Asp Ser Pro Ile Val Thr Asn Lys Ile Val Ala Ile Leu Glu Tyr Ala 
            20                  25                  30          


Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gln Asn 
        35                  40                  45              


Ile Lys His Arg Leu Lys Asn Gly Phe Ser Asn Gln Met Ile Ile Asn 
    50                  55                  60                  


Asn Val Glu Val Gly Asn Val Ile Lys Ser Lys Leu Arg Ser Tyr Pro 
65                  70                  75                  80  


Ala His Ser His Ile Pro Tyr Pro Asn Cys Asn Gln Asp Leu Phe Asn 
                85                  90                  95      


Ile Glu Asp Lys Glu Ser Thr Arg Lys Ile Arg Glu Leu Leu Lys Lys 
            100                 105                 110         


Gly Asn Ser Leu Tyr Ser Lys Val Ser Asp Lys Val Phe Gln Cys Leu 
        115                 120                 125             


Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 
    130                 135                 140                 


Ile Lys Glu Lys Val Ile Asn Leu Gly Val Tyr Met His Ser Ser Gln 
145                 150                 155                 160 


Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 
                165                 170                 175     


Ser Val Ile Lys Ser Gln Thr His Thr Cys His Arg Arg Arg His Thr 
            180                 185                 190         


Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu Ile Ser Arg Asp 
        195                 200                 205             


Leu Val Ala Ile Ile Ser Lys Glu Ser Gln His Val Tyr Tyr Leu Thr 
    210                 215                 220                 


Phe Glu Leu Val Leu Met Tyr Cys Asp Val Ile Glu Gly Arg Leu Met 
225                 230                 235                 240 


Thr Glu Thr Ala Met Thr Ile Asp Ala Arg Tyr Thr Glu Leu Leu Gly 
                245                 250                 255     


Arg Val Arg Tyr Met Trp Lys Leu Ile Asp Gly Phe Phe Pro Ala Leu 
            260                 265                 270         


Gly Asn Pro Thr Tyr Gln Ile Val Ala Met Leu Glu Pro Leu Ser Leu 
        275                 280                 285             


Ala Tyr Leu Gln Leu Arg Asp Ile Thr Val Glu Leu Arg Gly Ala Phe 
    290                 295                 300                 


Leu Asn His Cys Phe Thr Glu Ile His Asp Val Leu Asp Gln Asn Gly 
305                 310                 315                 320 


Phe Ser Asp Glu Gly Thr Tyr His Glu Leu Thr Glu Ala Leu Asp Tyr 
                325                 330                 335     


Ile Phe Ile Thr Asp Asp Ile His Leu Thr Gly Glu Ile Phe Ser Phe 
            340                 345                 350         


Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 
        355                 360                 365             


Asn Val Arg Lys Tyr Met Asn Gln Pro Lys Val Ile Val Tyr Glu Thr 
    370                 375                 380                 


Leu Met Lys Gly His Ala Ile Phe Cys Gly Ile Ile Ile Asn Gly Tyr 
385                 390                 395                 400 


Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 
                405                 410                 415     


Ala Ala Asp Thr Ile Arg Asn Ala Gln Ala Ser Gly Glu Gly Leu Thr 
            420                 425                 430         


His Glu Gln Cys Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lys Phe 
        435                 440                 445             


Gly Cys Phe Met Pro Leu Ser Leu Asp Ser Asp Leu Thr Met Tyr Leu 
    450                 455                 460                 


Lys Asp Lys Ala Leu Ala Ala Leu Gln Arg Glu Trp Asp Ser Val Tyr 
465                 470                 475                 480 


Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 
                485                 490                 495     


Arg Leu Val Asp Val Phe Leu Asn Asp Ser Ser Phe Asp Pro Tyr Asp 
            500                 505                 510         


Val Ile Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 
        515                 520                 525             


Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu Ile Lys Glu Thr Gly Arg 
    530                 535                 540                 


Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gln Val Ile Ala 
545                 550                 555                 560 


Glu Asn Leu Ile Ser Asn Gly Ile Gly Lys Tyr Phe Lys Asp Asn Gly 
                565                 570                 575     


Met Ala Lys Asp Glu His Asp Leu Thr Lys Ala Leu His Thr Leu Ala 
            580                 585                 590         


Val Ser Gly Val Pro Lys Asp Leu Lys Glu Ser His Arg Gly Gly Pro 
        595                 600                 605             


Val Leu Lys Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Asn 
    610                 615                 620                 


Val Arg Ala Ala Lys Gly Phe Ile Gly Phe Pro Gln Val Ile Arg Gln 
625                 630                 635                 640 


Asp Gln Asp Thr Asp His Pro Glu Asn Met Glu Ala Tyr Glu Thr Val 
                645                 650                 655     


Ser Ala Phe Ile Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 
            660                 665                 670         


Tyr Glu Thr Ile Ser Leu Phe Ala Gln Arg Leu Asn Glu Ile Tyr Gly 
        675                 680                 685             


Leu Pro Ser Phe Phe Gln Trp Leu His Lys Arg Leu Glu Thr Ser Val 
    690                 695                 700                 


Leu Tyr Val Ser Asp Pro His Cys Pro Pro Asp Leu Asp Ala His Ile 
705                 710                 715                 720 


Pro Leu Tyr Lys Val Pro Asn Asp Gln Ile Phe Ile Lys Tyr Pro Met 
                725                 730                 735     


Gly Gly Ile Glu Gly Tyr Cys Gln Lys Leu Trp Thr Ile Ser Thr Ile 
            740                 745                 750         


Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg Ile Ala Ser 
        755                 760                 765             


Leu Val Gln Gly Asp Asn Gln Thr Ile Ala Val Thr Lys Arg Val Pro 
    770                 775                 780                 


Ser Thr Trp Pro Tyr Asn Leu Lys Lys Arg Glu Ala Ala Arg Val Thr 
785                 790                 795                 800 


Arg Asp Tyr Phe Val Ile Leu Arg Gln Arg Leu His Asp Ile Gly His 
                805                 810                 815     


His Leu Lys Ala Asn Glu Thr Ile Val Ser Ser His Phe Phe Val Tyr 
            820                 825                 830         


Ser Lys Gly Ile Tyr Tyr Asp Gly Leu Leu Val Ser Gln Ser Leu Lys 
        835                 840                 845             


Ser Ile Ala Arg Cys Val Phe Trp Ser Glu Thr Ile Val Asp Glu Thr 
    850                 855                 860                 


Arg Ala Ala Cys Ser Asn Ile Ala Thr Thr Met Ala Lys Ser Ile Glu 
865                 870                 875                 880 


Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 
                885                 890                 895     


Ile Gln Gln Ile Leu Ile Ser Leu Gly Phe Thr Ile Asn Ser Thr Met 
            900                 905                 910         


Thr Arg Asp Val Val Ile Pro Leu Leu Thr Asn Asn Asp Leu Leu Ile 
        915                 920                 925             


Arg Met Ala Leu Leu Pro Ala Pro Ile Gly Gly Met Asn Tyr Leu Asn 
    930                 935                 940                 


Met Ser Arg Leu Phe Val Arg Asn Ile Gly Asp Pro Val Thr Ser Ser 
945                 950                 955                 960 


Ile Ala Asp Leu Lys Arg Met Ile Leu Ala Ser Leu Met Pro Glu Glu 
                965                 970                 975     


Thr Leu His Gln Val Met Thr Gln Gln Pro Gly Asp Ser Ser Phe Leu 
            980                 985                 990         


Asp Trp Ala Ser Asp Pro Tyr Ser  Ala Asn Leu Val Cys  Val Gln Ser 
        995                 1000                 1005             


Ile Thr  Arg Leu Leu Lys Asn  Ile Thr Ala Arg Phe  Val Leu Ile 
    1010                 1015                 1020             


His Ser  Pro Asn Pro Met Leu  Lys Gly Leu Phe His  Asp Asp Ser 
    1025                 1030                 1035             


Lys Glu  Glu Asp Glu Gly Leu  Ala Ala Phe Leu Met  Asp Arg His 
    1040                 1045                 1050             


Ile Ile  Val Pro Arg Ala Ala  His Glu Ile Leu Asp  His Ser Val 
    1055                 1060                 1065             


Thr Gly  Ala Arg Glu Ser Ile  Ala Gly Met Leu Asp  Thr Thr Lys 
    1070                 1075                 1080             


Gly Leu  Ile Arg Ala Ser Met  Arg Lys Gly Gly Leu  Thr Ser Arg 
    1085                 1090                 1095             


Val Ile  Thr Arg Leu Ser Asn  Tyr Asp Tyr Glu Gln  Phe Arg Ala 
    1100                 1105                 1110             


Gly Met  Val Leu Leu Thr Gly  Arg Lys Arg Asn Val  Leu Ile Asp 
    1115                 1120                 1125             


Lys Glu  Ser Cys Ser Val Gln  Leu Ala Arg Ala Leu  Arg Ser His 
    1130                 1135                 1140             


Met Trp  Ala Arg Leu Ala Arg  Gly Arg Pro Ile Tyr  Gly Leu Glu 
    1145                 1150                 1155             


Val Pro  Asp Val Leu Glu Ser  Met Arg Gly His Leu  Ile Arg Arg 
    1160                 1165                 1170             


His Glu  Thr Cys Val Ile Cys  Glu Cys Gly Ser Val  Asn Tyr Gly 
    1175                 1180                 1185             


Trp Phe  Phe Val Pro Ser Gly  Cys Gln Leu Asp Asp  Ile Asp Lys 
    1190                 1195                 1200             


Glu Thr  Ser Ser Leu Arg Val  Pro Tyr Ile Gly Ser  Thr Thr Asp 
    1205                 1210                 1215             


Glu Arg  Thr Asp Met Lys Leu  Ala Phe Val Arg Ala  Pro Ser Arg 
    1220                 1225                 1230             


Ser Leu  Arg Ser Ala Val Arg  Ile Ala Thr Val Tyr  Ser Trp Ala 
    1235                 1240                 1245             


Tyr Gly  Asp Asp Asp Ser Ser  Trp Asn Glu Ala Trp  Leu Leu Ala 
    1250                 1255                 1260             


Arg Gln  Arg Ala Asn Val Ser  Leu Glu Glu Leu Arg  Val Ile Thr 
    1265                 1270                 1275             


Pro Ile  Ser Thr Ser Thr Asn  Leu Ala His Arg Leu  Arg Asp Arg 
    1280                 1285                 1290             


Ser Thr  Gln Val Lys Tyr Ser  Gly Thr Ser Leu Val  Arg Val Ala 
    1295                 1300                 1305             


Arg Tyr  Thr Thr Ile Ser Asn  Asp Asn Leu Ser Phe  Val Ile Ser 
    1310                 1315                 1320             


Asp Lys  Lys Val Asp Thr Asn  Phe Ile Tyr Gln Gln  Gly Met Leu 
    1325                 1330                 1335             


Leu Gly  Leu Gly Val Leu Glu  Thr Leu Phe Arg Leu  Glu Lys Asp 
    1340                 1345                 1350             


Thr Gly  Ser Ser Asn Thr Val  Leu His Leu His Val  Glu Thr Asp 
    1355                 1360                 1365             


Cys Cys  Val Ile Pro Met Ile  Asp His Pro Arg Ile  Pro Ser Ser 
    1370                 1375                 1380             


Arg Lys  Leu Glu Leu Arg Ala  Glu Leu Cys Thr Asn  Pro Leu Ile 
    1385                 1390                 1395             


Tyr Asp  Asn Ala Pro Leu Ile  Asp Arg Asp Ala Thr  Arg Leu Tyr 
    1400                 1405                 1410             


Thr Gln  Ser His Arg Arg His  Leu Val Glu Phe Val  Thr Trp Ser 
    1415                 1420                 1425             


Thr Pro  Gln Leu Tyr His Ile  Leu Ala Lys Ser Thr  Ala Leu Ser 
    1430                 1435                 1440             


Met Ile  Asp Leu Val Thr Lys  Phe Glu Lys Asp His  Met Asn Glu 
    1445                 1450                 1455             


Ile Ser  Ala Leu Ile Gly Asp  Asp Asp Ile Asn Ser  Phe Ile Thr 
    1460                 1465                 1470             


Glu Phe  Leu Leu Ile Glu Pro  Arg Leu Phe Thr Ile  Tyr Leu Gly 
    1475                 1480                 1485             


Gln Cys  Ala Ala Ile Asn Trp  Ala Phe Asp Val His  Tyr His Arg 
    1490                 1495                 1500             


Pro Ser  Gly Lys Tyr Gln Met  Gly Glu Leu Leu Ser  Ser Phe Leu 
    1505                 1510                 1515             


Ser Arg  Met Ser Lys Gly Val  Phe Lys Val Leu Val  Asn Ala Leu 
    1520                 1525                 1530             


Ser His  Pro Lys Ile Tyr Lys  Lys Phe Trp His Cys  Gly Ile Ile 
    1535                 1540                 1545             


Glu Pro  Ile His Gly Pro Ser  Leu Asp Ala Gln Asn  Leu His Thr 
    1550                 1555                 1560             


Thr Val  Cys Asn Met Val Tyr  Thr Cys Tyr Met Thr  Tyr Leu Asp 
    1565                 1570                 1575             


Leu Leu  Leu Asn Glu Glu Leu  Glu Glu Phe Thr Phe  Leu Leu Cys 
    1580                 1585                 1590             


Glu Ser  Asp Glu Asp Val Val  Pro Asp Arg Phe Asp  Asn Ile Gln 
    1595                 1600                 1605             


Ala Lys  His Leu Cys Val Leu  Ala Asp Leu Tyr Cys  Gln Pro Gly 
    1610                 1615                 1620             


Thr Cys  Pro Pro Ile Arg Gly  Leu Arg Pro Val Glu  Lys Cys Ala 
    1625                 1630                 1635             


Val Leu  Thr Asp His Ile Lys  Ala Glu Ala Met Leu  Ser Pro Ala 
    1640                 1645                 1650             


Gly Ser  Ser Trp Asn Ile Asn  Pro Ile Ile Val Asp  His Tyr Ser 
    1655                 1660                 1665             


Cys Ser  Leu Thr Tyr Leu Arg  Arg Gly Ser Ile Lys  Gln Ile Arg 
    1670                 1675                 1680             


Leu Arg  Val Asp Pro Gly Phe  Ile Phe Asp Ala Leu  Ala Glu Val 
    1685                 1690                 1695             


Asn Val  Ser Gln Pro Lys Ile  Gly Ser Asn Asn Ile  Ser Asn Met 
    1700                 1705                 1710             


Ser Ile  Lys Ala Phe Arg Pro  Pro His Asp Asp Val  Ala Lys Leu 
    1715                 1720                 1725             


Leu Lys  Asp Ile Asn Thr Ser  Lys His Asn Leu Pro  Ile Ser Gly 
    1730                 1735                 1740             


Gly Asn  Leu Ala Asn Tyr Glu  Ile His Ala Phe Arg  Arg Ile Gly 
    1745                 1750                 1755             


Leu Asn  Ser Ser Ala Cys Tyr  Lys Ala Val Glu Ile  Ser Thr Leu 
    1760                 1765                 1770             


Ile Arg  Arg Cys Leu Glu Pro  Gly Glu Asp Gly Leu  Phe Leu Gly 
    1775                 1780                 1785             


Glu Gly  Ser Gly Ser Met Leu  Ile Thr Tyr Lys Glu  Ile Leu Lys 
    1790                 1795                 1800             


Leu Asn  Lys Cys Phe Tyr Asn  Ser Gly Val Ser Ala  Asn Ser Arg 
    1805                 1810                 1815             


Ser Gly  Gln Arg Glu Leu Ala  Pro Tyr Pro Ser Glu  Val Gly Leu 
    1820                 1825                 1830             


Val Glu  His Arg Met Gly Val  Gly Asn Ile Val Lys  Val Leu Phe 
    1835                 1840                 1845             


Asn Gly  Arg Pro Glu Val Thr  Trp Val Gly Ser Val  Asp Cys Phe 
    1850                 1855                 1860             


Asn Phe  Ile Val Ser Asn Ile  Pro Thr Ser Ser Val  Gly Phe Ile 
    1865                 1870                 1875             


His Ser  Asp Ile Glu Thr Leu  Pro Asp Lys Asp Thr  Ile Glu Lys 
    1880                 1885                 1890             


Leu Glu  Glu Leu Ala Ala Ile  Leu Ser Met Ala Leu  Leu Leu Gly 
    1895                 1900                 1905             


Lys Ile  Gly Ser Ile Leu Val  Ile Lys Leu Met Pro  Phe Ser Gly 
    1910                 1915                 1920             


Asp Phe  Val Gln Gly Phe Ile  Ser Tyr Val Gly Ser  His Tyr Arg 
    1925                 1930                 1935             


Glu Val  Asn Leu Val Tyr Pro  Arg Tyr Ser Asn Phe  Ile Ser Thr 
    1940                 1945                 1950             


Glu Ser  Tyr Leu Val Met Thr  Asp Leu Lys Ala Asn  Arg Leu Met 
    1955                 1960                 1965             


Asn Pro  Glu Lys Ile Lys Gln  Gln Ile Ile Glu Ser  Ser Val Arg 
    1970                 1975                 1980             


Thr Ser  Pro Gly Leu Ile Gly  His Ile Leu Ser Ile  Lys Gln Leu 
    1985                 1990                 1995             


Ser Cys  Ile Gln Ala Ile Val  Gly Asp Ala Val Ser  Arg Gly Asp 
    2000                 2005                 2010             


Ile Asn  Pro Thr Leu Lys Lys  Leu Thr Pro Ile Glu  Gln Val Leu 
    2015                 2020                 2025             


Ile Asn  Cys Gly Leu Ala Ile  Asn Gly Pro Lys Leu  Cys Lys Glu 
    2030                 2035                 2040             


Leu Ile  His His Asp Val Ala  Ser Gly Gln Asp Gly  Leu Leu Asn 
    2045                 2050                 2055             


Ser Ile  Leu Ile Leu Tyr Arg  Glu Leu Ala Arg Phe  Lys Asp Asn 
    2060                 2065                 2070             


Gln Arg  Ser Gln Gln Gly Met  Phe His Ala Tyr Pro  Val Leu Val 
    2075                 2080                 2085             


Ser Ser  Arg Gln Arg Glu Leu  Ile Ser Arg Ile Thr  Arg Lys Phe 
    2090                 2095                 2100             


Trp Gly  His Ile Leu Leu Tyr  Ser Gly Asn Lys Lys  Leu Ile Asn 
    2105                 2110                 2115             


Lys Phe  Ile Gln Asn Leu Lys  Ser Gly Tyr Leu Ile  Leu Asp Leu 
    2120                 2125                 2130             


His Gln  Asn Ile Phe Val Lys  Asn Leu Ser Lys Ser  Glu Lys Gln 
    2135                 2140                 2145             


Ile Ile  Met Thr Gly Gly Leu  Lys Arg Glu Trp Val  Phe Lys Val 
    2150                 2155                 2160             


Thr Val  Lys Glu Thr Lys Glu  Trp Tyr Lys Leu Val  Gly Tyr Ser 
    2165                 2170                 2175             


Ala Leu  Ile Lys Asp 
    2180             


<210>  14
<211>  3474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ubi - delta hTERT


<220>
<221>  CDS
<222>  (1)..(3474)
<223>  Ubi- delta hTERT

<400>  14
atg cag att ttc gtc aaa aca ttg aca gga aag acc atc aca ctg gaa         48
Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu           
1               5                   10                  15                

gtg gag cca agc gac act att gag aac gtc aaa gcc aag att cag gac         96
Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp           
            20                  25                  30                    

aag gag ggc atc cca cca gac cag cag agg ctg att ttt gcc gga aag        144
Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys           
        35                  40                  45                        

cag ctg gag gac gga cgc aca ctc agt gac tac aat atc cag aag gaa        192
Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu           
    50                  55                  60                            

agt act ctg cat ctg gtc ctt cgc ctg cgc ggc gga aga gct ctc gtc        240
Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Arg Ala Leu Val           
65                  70                  75                  80            

gcc cag tgt ctg gtc tgc gtt cct tgg gac gca cgg ccc cca ccc gcc        288
Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro Pro Pro Ala           
                85                  90                  95                

gcc ccc agt ttc cgg cag gtg agt tgt ctc aaa gag ttg gtt gct cgg        336
Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu Val Ala Arg           
            100                 105                 110                   

gtg ttg cag cgg ctt tgt gaa cgc gga gca aag aac gtc ctt gcc ttt        384
Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val Leu Ala Phe           
        115                 120                 125                       

ggc ttc gct ttg ctc gat gga gca cgc gga ggc cct cct gag gca ttc        432
Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro Glu Ala Phe           
    130                 135                 140                           

act act agc gtc cgg tcc tac ctg ccc aac aca gtg acc gac gct ctg        480
Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr Asp Ala Leu           
145                 150                 155                 160           

aga ggt tca ggt gcc tgg ggt ctg ctg ctg cgg agg gtg ggt gat gat        528
Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val Gly Asp Asp           
                165                 170                 175               

gtt ctg gtt cac ctc ctg gcc cgg tgt gcc ctg ttc gtg ctg gtg gct        576
Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val Leu Val Ala           
            180                 185                 190                   

ccc tcc tgc gca tac cag gtc tgc gga ccc cca ctt tat cag ctc ggc        624
Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr Gln Leu Gly           
        195                 200                 205                       

gct gct act cag gcc cgc cca cca cca cac gcc tca ggt cca aga cgc        672
Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly Pro Arg Arg           
    210                 215                 220                           

cgg ctg ggc tgc gaa cgg gca tgg aat cat agc gtg cgg gag gca ggt        720
Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg Glu Ala Gly           
225                 230                 235                 240           

gtg cct ctc ggc ctg cca gcc ccc gga gca agg aga cgc ggt gga tcc        768
Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg Gly Gly Ser           
                245                 250                 255               

gcc agt cgc tca ctc ccc ttg cct aag agg cca aga aga gga gcc gcc        816
Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg Gly Ala Ala           
            260                 265                 270                   

cct gaa ccc gag aga aca cct gtc ggc cag ggc tcc tgg gct cac ccc        864
Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp Ala His Pro           
        275                 280                 285                       

gga agg acc agg ggc cca agc gat agg ggc ttc tgt gtt gtg tca cca        912
Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val Val Ser Pro           
    290                 295                 300                           

gcc agg cct gcc gaa gag gct acc tcc ttg gaa gga gcc ctc agt ggc        960
Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala Leu Ser Gly           
305                 310                 315                 320           

acc agg cat tct cat cca tct gtg ggt agg cag cat cat gcc ggc ccc       1008
Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His Ala Gly Pro           
                325                 330                 335               

ccc tct aca agc aga cct ccc aga cct tgg gac aca ccc tgc cca cca       1056
Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro Cys Pro Pro           
            340                 345                 350                   

gtg tat gcc gag acc aag cac ttt ttg tat tcc agt ggc gat aaa gag       1104
Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly Asp Lys Glu           
        355                 360                 365                       

cag ctc cgg ccc tct ttt ctg ctc tca agc ctc cgc ccc tct ctg acc       1152
Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro Ser Leu Thr           
    370                 375                 380                           

gga gct cgc agg ctg gtg gag acc atc ttt ctg ggc tca aga cca tgg       1200
Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser Arg Pro Trp           
385                 390                 395                 400           

atg cca ggc acc ccc cgc aga ctg ccc agg ctc ccc cag cgg tac tgg       1248
Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln Arg Tyr Trp           
                405                 410                 415               

cag atg cgc cct ctc ttt ctg gaa ctt ctg ggt aac cac gcc cag tgc       1296
Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His Ala Gln Cys           
            420                 425                 430                   

cca tat ggc gtc ctg ctg aag acc cac tgt cct ctg agg gcc gcc gtg       1344
Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg Ala Ala Val           
        435                 440                 445                       

acc cca gcc gcc ggt gtg tgt gct aga gaa aaa ccc cag ggc tca gtg       1392
Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln Gly Ser Val           
    450                 455                 460                           

gct gca cct gaa gag gag gac act gac cct cgc cgc ctt gtc cag ttg       1440
Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu Val Gln Leu           
465                 470                 475                 480           

ctc agg cag cat tca tca cca tgg cag gtg tac ggc ttc gtg agg gct       1488
Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe Val Arg Ala           
                485                 490                 495               

tgc ctg cgg aga ctg gtc ccc ccc gga ttg tgg gga tct cgg cac aac       1536
Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser Arg His Asn           
            500                 505                 510                   

gaa cgg cgc ttt ctg agg aat aca aag aag ttt atc tcc ctg ggc aag       1584
Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser Leu Gly Lys           
        515                 520                 525                       

cat gca aag ctc agc ttg cag gag ctg aca tgg aag atg agc gtt aga       1632
His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met Ser Val Arg           
    530                 535                 540                           

gga tgc gca tgg ctc agg cgg tca cct gga gtt gga tgc gtt cca gca       1680
Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys Val Pro Ala           
545                 550                 555                 560           

gca gag cac agg ctg cgc gaa gag att ctc gca aag ttc ctg cac tgg       1728
Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe Leu His Trp           
                565                 570                 575               

ctt atg agc gtc tac gtg gtc gaa ctg ctg cgg tct ttc ttc tac gtg       1776
Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe Phe Tyr Val           
            580                 585                 590                   

aca gag acc act ttt cag aag aac aga ctg ttc ttc tac agg aag tcc       1824
Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr Arg Lys Ser           
        595                 600                 605                       

gtc tgg agc aag ctc cag agt att ggt att aga cag cac ctt aag aga       1872
Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His Leu Lys Arg           
    610                 615                 620                           

gtt cag ctt aga gag ctg tcc gaa gct gaa gtc cgc cag cac cgc gaa       1920
Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln His Arg Glu           
625                 630                 635                 640           

gct cgc ccc gcc ctc ctg acc tct cgg ctg cgg ttt att ccc aaa ccc       1968
Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys Pro           
                645                 650                 655               

gat ggc ctt aga cct atc gtg aat atg gat tac gtc gtg ggt gcc cgc       2016
Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val Gly Ala Arg           
            660                 665                 670                   

act ttc aga agg gag aag agg gcc gag aga ctg aca tct cgc gtg aag       2064
Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser Arg Val Lys           
        675                 680                 685                       

gca ctt ttt tct gtg ctt aat tat gaa aga gcc cgc aga cct ggt ctt       2112
Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu           
    690                 695                 700                           

ctc gga gcc agc gtg ctc ggc ctg gat gat atc cat cgg gct tgg cgc       2160
Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala Trp Arg           
705                 710                 715                 720           

acc ttt gtg ctt cgg gtg agg gca cag gat cct cct cct gag ctt tat       2208
Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu Leu Tyr           
                725                 730                 735               

ttt gtg aaa gtt gat gtt act ggt gct tac gat aca atc cct cag gac       2256
Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile Pro Gln Asp           
            740                 745                 750                   

cgg ctc acc gag gtg atc gcc tct att atc aaa ccc cag aac acc tac       2304
Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln Asn Thr Tyr           
        755                 760                 765                       

tgc gtg aga agg tac gcc gtc gtt cag aaa gcc gca cac gga cac gtg       2352
Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His Gly His Val           
    770                 775                 780                           

cgc aaa gct ttc aaa tcc cac gtg tct acc ttg aca gac ctc cag cct       2400
Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp Leu Gln Pro           
785                 790                 795                 800           

tat atg cgg cag ttt gtc gca cac ctg cag gag act agc ccc ttg agg       2448
Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser Pro Leu Arg           
                805                 810                 815               

gac gct gtg gtc atc gaa cag tcc agc tct ctc aat gag gca tcc tca       2496
Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu Ala Ser Ser           
            820                 825                 830                   

ggc ctg ttt gat gtg ttc ctg cgc ttt atg tgc cac cac gcc gtg cgg       2544
Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His Ala Val Arg           
        835                 840                 845                       

att agg ggc aag tct tac gtg cag tgc cag ggc atc cca cag ggt agc       2592
Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro Gln Gly Ser           
    850                 855                 860                           

atc ctg agc aca ctg ctg tgt agc ctg tgc tat ggc gat atg gag aat       2640
Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp Met Glu Asn           
865                 870                 875                 880           

aaa ttg ttc gcc ggt atc aga aga gac ggt ttg ctc ctg agg ctg ttc       2688
Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu Arg Leu Phe           
                885                 890                 895               

ctg ctg gtt acc ccc cat ctg act cat gcc aaa aca ttt ttg cgg act       2736
Leu Leu Val Thr Pro His Leu Thr His Ala Lys Thr Phe Leu Arg Thr           
            900                 905                 910                   

ctg gtt agg ggc gtg cca gag tat ggc tgt gtt gtg aat ttg cgg aaa       2784
Leu Val Arg Gly Val Pro Glu Tyr Gly Cys Val Val Asn Leu Arg Lys           
        915                 920                 925                       

act gtg gtt aat ttc cca gtg gag gac gaa gct ctc gga ggc aca gct       2832
Thr Val Val Asn Phe Pro Val Glu Asp Glu Ala Leu Gly Gly Thr Ala           
    930                 935                 940                           

ttt gtt cag atg cct gcc cac ggc ctg ttc cca tgg tgc gga ctg ctg       2880
Phe Val Gln Met Pro Ala His Gly Leu Phe Pro Trp Cys Gly Leu Leu           
945                 950                 955                 960           

ctc gat acc cgg acc ctc gag gtg cag tcc gat tat agt tcc tat gca       2928
Leu Asp Thr Arg Thr Leu Glu Val Gln Ser Asp Tyr Ser Ser Tyr Ala           
                965                 970                 975               

aga aca tca att cgg gct agc ctg act ttc aac agg ggc ttc aag gcc       2976
Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe Asn Arg Gly Phe Lys Ala           
            980                 985                 990                   

ggc cgg aat atg aga agg aaa ctg  ttc gga gtg ttg aga  ctt aag tgt     3024
Gly Arg Asn Met Arg Arg Lys Leu  Phe Gly Val Leu Arg  Leu Lys Cys         
        995                 1000                 1005                     

cat agt  ctt ttt ttg gac ttg  cag gtc aat tct ctc  cag aca gtg        3069
His Ser  Leu Phe Leu Asp Leu  Gln Val Asn Ser Leu  Gln Thr Val            
    1010                 1015                 1020                        

tgt acc  aac att tat aaa atc  ctc ttg ctg cag gct  tac aga ttc        3114
Cys Thr  Asn Ile Tyr Lys Ile  Leu Leu Leu Gln Ala  Tyr Arg Phe            
    1025                 1030                 1035                        

cat gcc  tgc gtc ctg cag ctg  cct ttc cac cag cag  gtg tgg aaa        3159
His Ala  Cys Val Leu Gln Leu  Pro Phe His Gln Gln  Val Trp Lys            
    1040                 1045                 1050                        

aac cct  acc ttc ttc ctg cgg  gtg att agc gac acc  gcc agt ctt        3204
Asn Pro  Thr Phe Phe Leu Arg  Val Ile Ser Asp Thr  Ala Ser Leu            
    1055                 1060                 1065                        

tgc tac  tcc atc ttg aaa gca  aaa aac gct ggc atg  agc ttg gga        3249
Cys Tyr  Ser Ile Leu Lys Ala  Lys Asn Ala Gly Met  Ser Leu Gly            
    1070                 1075                 1080                        

gct aag  ggc gcc gct gga cct  ctg ccc agt gaa gca  gtc cag tgg        3294
Ala Lys  Gly Ala Ala Gly Pro  Leu Pro Ser Glu Ala  Val Gln Trp            
    1085                 1090                 1095                        

ctg tgt  cat cag gct ttc ctc  ctt aaa ctg aca cgc  cac cgc gtg        3339
Leu Cys  His Gln Ala Phe Leu  Leu Lys Leu Thr Arg  His Arg Val            
    1100                 1105                 1110                        

act tac  gtc cca ctc ctg ggc  tcc ctg aga act gct  cag acc cag        3384
Thr Tyr  Val Pro Leu Leu Gly  Ser Leu Arg Thr Ala  Gln Thr Gln            
    1115                 1120                 1125                        

ctt tcc  cgg aag ctt cca ggc  act acc ctt acc gca  ctc gaa gca        3429
Leu Ser  Arg Lys Leu Pro Gly  Thr Thr Leu Thr Ala  Leu Glu Ala            
    1130                 1135                 1140                        

gcc gcc  aac cct gcc ctg ccc  tcc gac ttt aag act  atc ctg gac        3474
Ala Ala  Asn Pro Ala Leu Pro  Ser Asp Phe Lys Thr  Ile Leu Asp            
    1145                 1150                 1155                        


<210>  15
<211>  1158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Arg Ala Leu Val 
65                  70                  75                  80  


Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro Pro Pro Ala 
                85                  90                  95      


Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu Val Ala Arg 
            100                 105                 110         


Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val Leu Ala Phe 
        115                 120                 125             


Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro Glu Ala Phe 
    130                 135                 140                 


Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr Asp Ala Leu 
145                 150                 155                 160 


Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val Gly Asp Asp 
                165                 170                 175     


Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val Leu Val Ala 
            180                 185                 190         


Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr Gln Leu Gly 
        195                 200                 205             


Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly Pro Arg Arg 
    210                 215                 220                 


Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg Glu Ala Gly 
225                 230                 235                 240 


Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg Gly Gly Ser 
                245                 250                 255     


Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg Gly Ala Ala 
            260                 265                 270         


Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp Ala His Pro 
        275                 280                 285             


Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val Val Ser Pro 
    290                 295                 300                 


Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala Leu Ser Gly 
305                 310                 315                 320 


Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His Ala Gly Pro 
                325                 330                 335     


Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro Cys Pro Pro 
            340                 345                 350         


Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly Asp Lys Glu 
        355                 360                 365             


Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro Ser Leu Thr 
    370                 375                 380                 


Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser Arg Pro Trp 
385                 390                 395                 400 


Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln Arg Tyr Trp 
                405                 410                 415     


Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His Ala Gln Cys 
            420                 425                 430         


Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg Ala Ala Val 
        435                 440                 445             


Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln Gly Ser Val 
    450                 455                 460                 


Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu Val Gln Leu 
465                 470                 475                 480 


Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe Val Arg Ala 
                485                 490                 495     


Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser Arg His Asn 
            500                 505                 510         


Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser Leu Gly Lys 
        515                 520                 525             


His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met Ser Val Arg 
    530                 535                 540                 


Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys Val Pro Ala 
545                 550                 555                 560 


Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe Leu His Trp 
                565                 570                 575     


Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe Phe Tyr Val 
            580                 585                 590         


Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr Arg Lys Ser 
        595                 600                 605             


Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His Leu Lys Arg 
    610                 615                 620                 


Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln His Arg Glu 
625                 630                 635                 640 


Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys Pro 
                645                 650                 655     


Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val Gly Ala Arg 
            660                 665                 670         


Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser Arg Val Lys 
        675                 680                 685             


Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu 
    690                 695                 700                 


Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala Trp Arg 
705                 710                 715                 720 


Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu Leu Tyr 
                725                 730                 735     


Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile Pro Gln Asp 
            740                 745                 750         


Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln Asn Thr Tyr 
        755                 760                 765             


Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His Gly His Val 
    770                 775                 780                 


Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp Leu Gln Pro 
785                 790                 795                 800 


Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser Pro Leu Arg 
                805                 810                 815     


Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu Ala Ser Ser 
            820                 825                 830         


Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His Ala Val Arg 
        835                 840                 845             


Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro Gln Gly Ser 
    850                 855                 860                 


Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp Met Glu Asn 
865                 870                 875                 880 


Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu Arg Leu Phe 
                885                 890                 895     


Leu Leu Val Thr Pro His Leu Thr His Ala Lys Thr Phe Leu Arg Thr 
            900                 905                 910         


Leu Val Arg Gly Val Pro Glu Tyr Gly Cys Val Val Asn Leu Arg Lys 
        915                 920                 925             


Thr Val Val Asn Phe Pro Val Glu Asp Glu Ala Leu Gly Gly Thr Ala 
    930                 935                 940                 


Phe Val Gln Met Pro Ala His Gly Leu Phe Pro Trp Cys Gly Leu Leu 
945                 950                 955                 960 


Leu Asp Thr Arg Thr Leu Glu Val Gln Ser Asp Tyr Ser Ser Tyr Ala 
                965                 970                 975     


Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe Asn Arg Gly Phe Lys Ala 
            980                 985                 990         


Gly Arg Asn Met Arg Arg Lys Leu  Phe Gly Val Leu Arg  Leu Lys Cys 
        995                 1000                 1005             


His Ser  Leu Phe Leu Asp Leu  Gln Val Asn Ser Leu  Gln Thr Val 
    1010                 1015                 1020             


Cys Thr  Asn Ile Tyr Lys Ile  Leu Leu Leu Gln Ala  Tyr Arg Phe 
    1025                 1030                 1035             


His Ala  Cys Val Leu Gln Leu  Pro Phe His Gln Gln  Val Trp Lys 
    1040                 1045                 1050             


Asn Pro  Thr Phe Phe Leu Arg  Val Ile Ser Asp Thr  Ala Ser Leu 
    1055                 1060                 1065             


Cys Tyr  Ser Ile Leu Lys Ala  Lys Asn Ala Gly Met  Ser Leu Gly 
    1070                 1075                 1080             


Ala Lys  Gly Ala Ala Gly Pro  Leu Pro Ser Glu Ala  Val Gln Trp 
    1085                 1090                 1095             


Leu Cys  His Gln Ala Phe Leu  Leu Lys Leu Thr Arg  His Arg Val 
    1100                 1105                 1110             


Thr Tyr  Val Pro Leu Leu Gly  Ser Leu Arg Thr Ala  Gln Thr Gln 
    1115                 1120                 1125             


Leu Ser  Arg Lys Leu Pro Gly  Thr Thr Leu Thr Ala  Leu Glu Ala 
    1130                 1135                 1140             


Ala Ala  Asn Pro Ala Leu Pro  Ser Asp Phe Lys Thr  Ile Leu Asp 
    1145                 1150                 1155             


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Leu Ala Lys Phe Leu His Trp Leu 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Tyr Leu Phe Phe Tyr Arg Lys Ser Val 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Leu Gln Val Asn Ser Leu Gln Thr Val 
1               5                   10  


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Val Trp Ser Lys Leu Gln Ser Ile 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Leu Cys Tyr Ser Ile Leu Lys Ala 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

His Ala Gln Cys Pro Tyr Gly Val Leu 
1               5                   


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ala Tyr Arg Phe His Ala Cys Val Leu 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Pro Ile Val Asn Met Asp Tyr Val 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile 
1               5                   10  


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Cys Val Pro Trp Asp Ala Arg Pro Pro Pro Ala Ala Pro Ser 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Val Pro Trp Asp Ala Arg Pro Pro Pro Ala Ala Pro Ser Phe 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Pro Trp Asp Ala Arg Pro Pro Pro Ala Ala Pro Ser Phe Arg 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Arg Gln His His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Leu Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu Ala Val 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Thr Leu Thr Ala Leu Glu Ala Ala Ala Asn Pro Ala Leu Pro Ser 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Leu Thr Ala Leu Glu Ala Ala Ala Asn Pro Ala Leu Pro Ser Asp 
1               5                   10                  15  


