﻿               SEQUENCE LISTING

<110> Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
     
<120> Inhibitors of IL-38 for use in treating and/or preventing cancer in a subject

<130> FH59078PC

<150> EP17170237.6
<151> 2017-05-09

<160> 30

<170> BiSSAP 1.3.6

<210> 1
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 light chain variable

<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Tyr Tyr Ser Tyr 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Phe Ala Pro Ile Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 2
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 heavy chain variable

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Pro Tyr Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser Gly Trp Ala 
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210> 3
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 light chain variable

<400> 3
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Trp Ser Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 4
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 heavy chain variable

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Tyr Ser 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Pro Ser Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Pro Val Pro His Val Trp Pro Tyr Ser Gly Phe Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 lc CDR1

<400> 5
Gln Ser Tyr Tyr Ser Tyr 
1               5       

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 lc CDR3

<400> 6
Gln Gln Val Phe Ala Pro Ile Thr 
1               5               

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc CDR1

<400> 7
Gly Phe Ser Phe Ser Ser Ser Ser 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc CDR2

<400> 8
Ile Ser Pro Tyr Tyr Ser Tyr Thr 
1               5               

<210> 9
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc CDR3

<400> 9
Ala Arg Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser Gly Trp Ala 
1               5                   10                  15      
Met Asp Tyr 
            

<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 lc CDR1

<400> 10
Gln Ser Val Ser Ser Ala 
1               5       

<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 lc CDR3

<400> 11
Gln Gln Ala Tyr Trp Ser Pro Ile Thr 
1               5                   

<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc CDR1

<400> 12
Gly Phe Ser Leu Ser Tyr Ser Tyr 
1               5               

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc CDR2

<400> 13
Ile Ser Pro Ser Tyr Ser Tyr Thr 
1               5               

<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc CDR3

<400> 14
Ala Arg Ala Pro Val Pro His Val Trp Pro Tyr Ser Gly Phe Asp Tyr 
1               5                   10                  15      



<210> 15
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 lc FR1

<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      

<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 lc FR2

<400> 16
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      
Tyr 
    

<210> 17
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 lc FR3

<400> 17
Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          
Thr Tyr Tyr Cys 
        35      

<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 lc FR4

<400> 18
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 19
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc FR1

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  

<210> 20
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc FR2

<400> 20
Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      
Ser 
    

<210> 21
<211> 38
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc FR3

<400> 21
Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
1               5                   10                  15      
Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys 
        35              

<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab E04 hc FR4

<400> 22
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 23
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 lc FR1

<400> 23
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      

<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 lc FR2

<400> 24
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      
Tyr 
    

<210> 25
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 lc FR3

<400> 25
Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          
Thr Tyr Tyr Cys 
        35      

<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 lc FR4

<400> 26
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 27
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc FR1

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  

<210> 28
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc FR2

<400> 28
Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      
Ser 
    

<210> 29
<211> 38
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc FR3

<400> 29
Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
1               5                   10                  15      
Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys 
        35              

<210> 30
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fab H06 hc FR4

<400> 30
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

