                         SEQUENCE LISTING

<110>  Institute of Genetics and Developmental Biology, Chinese 
       Academy of Sciences
       China Agricultural University
 
<120>  Creation of herbicide resistant gene and use thereof

<130>  P20182461

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  2320
<212>  PRT
<213>  Alopecurus myosuroides

<400>  1

Met Gly Ser Thr His Leu Pro Ile Val Gly Phe Asn Ala Ser Thr Thr 
1               5                   10                  15      


Pro Ser Leu Ser Thr Leu Arg Gln Ile Asn Ser Ala Ala Ala Ala Phe 
            20                  25                  30          


Gln Ser Ser Ser Pro Ser Arg Ser Ser Lys Lys Lys Ser Arg Arg Val 
        35                  40                  45              


Lys Ser Ile Arg Asp Asp Gly Asp Gly Ser Val Pro Asp Pro Ala Gly 
    50                  55                  60                  


His Gly Gln Ser Ile Arg Gln Gly Leu Ala Gly Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Lys Glu Gly Ala Ser Ala Pro Asp Val Asp Ile Ser His Gly Ser Glu 
                85                  90                  95      


Asp His Lys Ala Ser Tyr Gln Met Asn Gly Ile Leu Asn Glu Ser His 
            100                 105                 110         


Asn Gly Arg His Ala Ser Leu Ser Lys Val Tyr Glu Phe Cys Thr Glu 
        115                 120                 125             


Leu Gly Gly Lys Thr Pro Ile His Ser Val Leu Val Ala Asn Asn Gly 
    130                 135                 140                 


Met Ala Ala Ala Lys Phe Met Arg Ser Val Arg Thr Trp Ala Asn Asp 
145                 150                 155                 160 


Thr Phe Gly Ser Glu Lys Ala Ile Gln Leu Ile Ala Met Ala Thr Pro 
                165                 170                 175     


Glu Asp Met Arg Ile Asn Ala Glu His Ile Arg Ile Ala Asp Gln Phe 
            180                 185                 190         


Val Glu Val Pro Gly Gly Thr Asn Asn Asn Asn Tyr Ala Asn Val Gln 
        195                 200                 205             


Leu Ile Val Glu Ile Ala Glu Arg Thr Gly Val Ser Ala Val Trp Pro 
    210                 215                 220                 


Gly Trp Gly His Ala Ser Glu Asn Pro Glu Leu Pro Asp Ala Leu Thr 
225                 230                 235                 240 


Ala Lys Gly Ile Val Phe Leu Gly Pro Pro Ala Ser Ser Met Asn Ala 
                245                 250                 255     


Leu Gly Asp Lys Val Gly Ser Ala Leu Ile Ala Gln Ala Ala Gly Val 
            260                 265                 270         


Pro Thr Leu Ala Trp Ser Gly Ser His Val Glu Ile Pro Leu Glu Leu 
        275                 280                 285             


Cys Leu Asp Ser Ile Pro Glu Glu Met Tyr Arg Lys Ala Cys Val Thr 
    290                 295                 300                 


Thr Ala Asp Glu Ala Val Ala Ser Cys Gln Met Ile Gly Tyr Pro Ala 
305                 310                 315                 320 


Met Ile Lys Ala Ser Trp Gly Gly Gly Gly Lys Gly Ile Arg Lys Val 
                325                 330                 335     


Asn Asn Asp Asp Glu Val Lys Ala Leu Phe Lys Gln Val Gln Gly Glu 
            340                 345                 350         


Val Pro Gly Ser Pro Ile Phe Ile Met Arg Leu Ala Ser Gln Ser Arg 
        355                 360                 365             


His Leu Glu Val Gln Leu Leu Cys Asp Glu Tyr Gly Asn Val Ala Ala 
    370                 375                 380                 


Leu His Ser Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile 
385                 390                 395                 400 


Glu Glu Gly Pro Val Thr Val Ala Pro Arg Glu Thr Val Lys Glu Leu 
                405                 410                 415     


Glu Gln Ala Ala Arg Arg Leu Ala Lys Ala Val Gly Tyr Val Gly Ala 
            420                 425                 430         


Ala Thr Val Glu Tyr Leu Tyr Ser Met Glu Thr Gly Glu Tyr Tyr Phe 
        435                 440                 445             


Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Val Thr Glu Ser 
    450                 455                 460                 


Ile Ala Glu Val Asn Leu Pro Ala Ala Gln Val Ala Val Gly Met Gly 
465                 470                 475                 480 


Ile Pro Leu Trp Gln Ile Pro Glu Ile Arg Arg Phe Tyr Gly Met Asp 
                485                 490                 495     


Asn Gly Gly Gly Tyr Asp Ile Trp Arg Lys Thr Ala Ala Leu Ala Thr 
            500                 505                 510         


Pro Phe Asn Phe Asp Glu Val Asp Ser Gln Trp Pro Lys Gly His Cys 
        515                 520                 525             


Val Ala Val Arg Ile Thr Ser Glu Asn Pro Asp Asp Gly Phe Lys Pro 
    530                 535                 540                 


Thr Gly Gly Lys Val Lys Glu Ile Ser Phe Lys Ser Lys Pro Asn Val 
545                 550                 555                 560 


Trp Gly Tyr Phe Ser Val Lys Ser Gly Gly Gly Ile His Glu Phe Ala 
                565                 570                 575     


Asp Ser Gln Phe Gly His Val Phe Ala Tyr Gly Glu Thr Arg Ser Ala 
            580                 585                 590         


Ala Ile Thr Ser Met Ser Leu Ala Leu Lys Glu Ile Gln Ile Arg Gly 
        595                 600                 605             


Glu Ile His Thr Asn Val Asp Tyr Thr Val Asp Leu Leu Asn Ala Pro 
    610                 615                 620                 


Asp Phe Arg Glu Asn Thr Ile His Thr Gly Trp Leu Asp Thr Arg Ile 
625                 630                 635                 640 


Ala Met Arg Val Gln Ala Glu Arg Pro Pro Trp Tyr Ile Ser Val Val 
                645                 650                 655     


Gly Gly Ala Leu Tyr Lys Thr Ile Thr Thr Asn Ala Glu Thr Val Ser 
            660                 665                 670         


Glu Tyr Val Ser Tyr Leu Ile Lys Gly Gln Ile Pro Pro Lys His Ile 
        675                 680                 685             


Ser Leu Val His Ser Thr Ile Ser Leu Asn Ile Glu Glu Ser Lys Tyr 
    690                 695                 700                 


Thr Ile Glu Ile Val Arg Ser Gly Gln Gly Ser Tyr Arg Leu Arg Leu 
705                 710                 715                 720 


Asn Gly Ser Leu Ile Glu Ala Asn Val Gln Thr Leu Cys Asp Gly Gly 
                725                 730                 735     


Leu Leu Met Gln Leu Asp Gly Asn Ser His Val Ile Tyr Ala Glu Glu 
            740                 745                 750         


Glu Ala Gly Gly Thr Arg Leu Leu Ile Asp Gly Lys Thr Cys Leu Leu 
        755                 760                 765             


Gln Asn Asp His Asp Pro Ser Arg Leu Leu Ala Glu Thr Pro Cys Lys 
    770                 775                 780                 


Leu Leu Arg Phe Leu Ile Ala Asp Gly Ala His Val Asp Ala Asp Val 
785                 790                 795                 800 


Pro Tyr Ala Glu Val Glu Val Met Lys Met Cys Met Pro Leu Leu Ser 
                805                 810                 815     


Pro Ala Ala Gly Val Ile Asn Val Leu Leu Ser Glu Gly Gln Ala Met 
            820                 825                 830         


Gln Ala Gly Asp Leu Ile Ala Arg Leu Asp Leu Asp Asp Pro Ser Ala 
        835                 840                 845             


Val Lys Arg Ala Glu Pro Phe Glu Gly Ser Phe Pro Glu Met Ser Leu 
    850                 855                 860                 


Pro Ile Ala Ala Ser Gly Gln Val His Lys Arg Cys Ala Ala Ser Leu 
865                 870                 875                 880 


Asn Ala Ala Arg Met Val Leu Ala Gly Tyr Asp His Ala Ala Asn Lys 
                885                 890                 895     


Val Val Gln Asp Leu Val Trp Cys Leu Asp Thr Pro Ala Leu Pro Phe 
            900                 905                 910         


Leu Gln Trp Glu Glu Leu Met Ser Val Leu Ala Thr Arg Leu Pro Arg 
        915                 920                 925             


Arg Leu Lys Ser Glu Leu Glu Gly Lys Tyr Asn Glu Tyr Lys Leu Asn 
    930                 935                 940                 


Val Asp His Val Lys Ile Lys Asp Phe Pro Thr Glu Met Leu Arg Glu 
945                 950                 955                 960 


Thr Ile Glu Glu Asn Leu Ala Cys Val Ser Glu Lys Glu Met Val Thr 
                965                 970                 975     


Ile Glu Arg Leu Val Asp Pro Leu Met Ser Leu Leu Lys Ser Tyr Glu 
            980                 985                 990         


Gly Gly Arg Glu Ser His Ala His  Phe Ile Val Lys Ser  Leu Phe Glu 
        995                 1000                 1005             


Glu Tyr  Leu Ser Val Glu Glu  Leu Phe Ser Asp Gly  Ile Gln Ser 
    1010                 1015                 1020             


Asp Val  Ile Glu Arg Leu Arg  Leu Gln Tyr Ser Lys  Asp Leu Gln 
    1025                 1030                 1035             


Lys Val  Val Asp Ile Val Leu  Ser His Gln Gly Val  Arg Asn Lys 
    1040                 1045                 1050             


Thr Lys  Leu Ile Leu Ala Leu  Met Glu Lys Leu Val  Tyr Pro Asn 
    1055                 1060                 1065             


Pro Ala  Ala Tyr Arg Asp Gln  Leu Ile Arg Phe Ser  Ser Leu Asn 
    1070                 1075                 1080             


His Lys  Arg Tyr Tyr Lys Leu  Ala Leu Lys Ala Ser  Glu Leu Leu 
    1085                 1090                 1095             


Glu Gln  Thr Lys Leu Ser Glu  Leu Arg Thr Ser Ile  Ala Arg Asn 
    1100                 1105                 1110             


Leu Ser  Ala Leu Asp Met Phe  Thr Glu Glu Lys Ala  Asp Phe Ser 
    1115                 1120                 1125             


Leu Gln  Asp Arg Lys Leu Ala  Ile Asn Glu Ser Met  Gly Asp Leu 
    1130                 1135                 1140             


Val Thr  Ala Pro Leu Pro Val  Glu Asp Ala Leu Val  Ser Leu Phe 
    1145                 1150                 1155             


Asp Cys  Thr Asp Gln Thr Leu  Gln Gln Arg Val Ile  Gln Thr Tyr 
    1160                 1165                 1170             


Ile Ser  Arg Leu Tyr Gln Pro  Gln Leu Val Lys Asp  Ser Ile Gln 
    1175                 1180                 1185             


Leu Lys  Tyr Gln Asp Ser Gly  Val Ile Ala Leu Trp  Glu Phe Thr 
    1190                 1195                 1200             


Glu Gly  Asn His Glu Lys Arg  Leu Gly Ala Met Val  Ile Leu Lys 
    1205                 1210                 1215             


Ser Leu  Glu Ser Val Ser Thr  Ala Ile Gly Ala Ala  Leu Lys Asp 
    1220                 1225                 1230             


Ala Ser  His Tyr Ala Ser Ser  Ala Gly Asn Thr Val  His Ile Ala 
    1235                 1240                 1245             


Leu Leu  Asp Ala Asp Thr Gln  Leu Asn Thr Thr Glu  Asp Ser Gly 
    1250                 1255                 1260             


Asp Asn  Asp Gln Ala Gln Asp  Lys Met Asp Lys Leu  Ser Phe Val 
    1265                 1270                 1275             


Leu Lys  Gln Asp Val Val Met  Ala Asp Leu Arg Ala  Ala Asp Val 
    1280                 1285                 1290             


Lys Val  Val Ser Cys Ile Val  Gln Arg Asp Gly Ala  Ile Met Pro 
    1295                 1300                 1305             


Met Arg  Arg Thr Phe Leu Leu  Ser Glu Glu Lys Leu  Cys Tyr Glu 
    1310                 1315                 1320             


Glu Glu  Pro Ile Leu Arg His  Val Glu Pro Pro Leu  Ser Ala Leu 
    1325                 1330                 1335             


Leu Glu  Leu Asp Lys Leu Lys  Val Lys Gly Tyr Asn  Glu Met Lys 
    1340                 1345                 1350             


Tyr Thr  Pro Ser Arg Asp Arg  Gln Trp His Ile Tyr  Thr Leu Arg 
    1355                 1360                 1365             


Asn Thr  Glu Asn Pro Lys Met  Leu His Arg Val Phe  Phe Arg Thr 
    1370                 1375                 1380             


Leu Val  Arg Gln Pro Ser Ala  Gly Asn Arg Phe Thr  Ser Asp His 
    1385                 1390                 1395             


Ile Thr  Asp Val Glu Val Gly  His Ala Glu Glu Pro  Leu Ser Phe 
    1400                 1405                 1410             


Thr Ser  Ser Ser Ile Leu Lys  Ser Leu Lys Ile Ala  Lys Glu Glu 
    1415                 1420                 1425             


Leu Glu  Leu His Ala Ile Arg  Thr Gly His Ser His  Met Tyr Leu 
    1430                 1435                 1440             


Cys Ile  Leu Lys Glu Gln Lys  Leu Leu Asp Leu Val  Pro Val Ser 
    1445                 1450                 1455             


Gly Asn  Thr Val Val Asp Val  Gly Gln Asp Glu Ala  Thr Ala Cys 
    1460                 1465                 1470             


Ser Leu  Leu Lys Glu Met Ala  Leu Lys Ile His Glu  Leu Val Gly 
    1475                 1480                 1485             


Ala Arg  Met His His Leu Ser  Val Cys Gln Trp Glu  Val Lys Leu 
    1490                 1495                 1500             


Lys Leu  Val Ser Asp Gly Pro  Ala Ser Gly Ser Trp  Arg Val Val 
    1505                 1510                 1515             


Thr Thr  Asn Val Thr Gly His  Thr Cys Thr Val Asp  Ile Tyr Arg 
    1520                 1525                 1530             


Glu Val  Glu Asp Thr Glu Ser  Gln Lys Leu Val Tyr  His Ser Thr 
    1535                 1540                 1545             


Ala Leu  Ser Ser Gly Pro Leu  His Gly Val Ala Leu  Asn Thr Ser 
    1550                 1555                 1560             


Tyr Gln  Pro Leu Ser Val Ile  Asp Leu Lys Arg Cys  Ser Ala Arg 
    1565                 1570                 1575             


Asn Asn  Lys Thr Thr Tyr Cys  Tyr Asp Phe Pro Leu  Thr Phe Glu 
    1580                 1585                 1590             


Ala Ala  Val Gln Lys Ser Trp  Ser Asn Ile Ser Ser  Glu Asn Asn 
    1595                 1600                 1605             


Gln Cys  Tyr Val Lys Ala Thr  Glu Leu Val Phe Ala  Glu Lys Asn 
    1610                 1615                 1620             


Gly Ser  Trp Gly Thr Pro Ile  Ile Pro Met Gln Arg  Ala Ala Gly 
    1625                 1630                 1635             


Leu Asn  Asp Ile Gly Met Val  Ala Trp Ile Leu Asp  Met Ser Thr 
    1640                 1645                 1650             


Pro Glu  Phe Pro Ser Gly Arg  Gln Ile Ile Val Ile  Ala Asn Asp 
    1655                 1660                 1665             


Ile Thr  Phe Arg Ala Gly Ser  Phe Gly Pro Arg Glu  Asp Ala Phe 
    1670                 1675                 1680             


Phe Glu  Ala Val Thr Asn Leu  Ala Cys Glu Lys Lys  Leu Pro Leu 
    1685                 1690                 1695             


Ile Tyr  Leu Ala Ala Asn Ser  Gly Ala Arg Ile Gly  Ile Ala Asp 
    1700                 1705                 1710             


Glu Val  Lys Ser Cys Phe Arg  Val Gly Trp Thr Asp  Asp Ser Ser 
    1715                 1720                 1725             


Pro Glu  Arg Gly Phe Arg Tyr  Ile Tyr Met Thr Asp  Glu Asp His 
    1730                 1735                 1740             


Asp Arg  Ile Gly Ser Ser Val  Ile Ala His Lys Met  Gln Leu Asp 
    1745                 1750                 1755             


Ser Gly  Glu Ile Arg Trp Val  Ile Asp Ser Val Val  Gly Lys Glu 
    1760                 1765                 1770             


Asp Gly  Leu Gly Val Glu Asn  Ile His Gly Ser Ala  Ala Ile Ala 
    1775                 1780                 1785             


Ser Ala  Tyr Ser Arg Ala Tyr  Glu Glu Thr Phe Thr  Leu Thr Phe 
    1790                 1795                 1800             


Val Thr  Gly Arg Thr Val Gly  Ile Gly Ala Tyr Leu  Ala Arg Leu 
    1805                 1810                 1815             


Gly Ile  Arg Cys Ile Gln Arg  Ile Asp Gln Pro Ile  Ile Leu Thr 
    1820                 1825                 1830             


Gly Phe  Ser Ala Leu Asn Lys  Leu Leu Gly Arg Glu  Val Tyr Ser 
    1835                 1840                 1845             


Ser His  Met Gln Leu Gly Gly  Pro Lys Ile Met Ala  Thr Asn Gly 
    1850                 1855                 1860             


Val Val  His Leu Thr Val Pro  Asp Asp Leu Glu Gly  Val Ser Asn 
    1865                 1870                 1875             


Ile Leu  Arg Trp Leu Ser Tyr  Val Pro Ala Asn Ile  Gly Gly Pro 
    1880                 1885                 1890             


Leu Pro  Ile Thr Lys Ser Leu  Asp Pro Ile Asp Arg  Pro Val Ala 
    1895                 1900                 1905             


Tyr Ile  Pro Glu Asn Thr Cys  Asp Pro Arg Ala Ala  Ile Ser Gly 
    1910                 1915                 1920             


Ile Asp  Asp Ser Gln Gly Lys  Trp Leu Gly Gly Met  Phe Asp Lys 
    1925                 1930                 1935             


Asp Ser  Phe Val Glu Thr Phe  Glu Gly Trp Ala Lys  Thr Val Val 
    1940                 1945                 1950             


Thr Gly  Arg Ala Lys Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala 
    1955                 1960                 1965             


Val Glu  Thr Gln Thr Met Met  Gln Leu Val Pro Ala  Asp Pro Gly 
    1970                 1975                 1980             


Gln Pro  Asp Ser His Glu Arg  Ser Val Pro Arg Ala  Gly Gln Val 
    1985                 1990                 1995             


Trp Phe  Pro Asp Ser Ala Thr  Lys Thr Ala Gln Ala  Met Leu Asp 
    2000                 2005                 2010             


Phe Asn  Arg Glu Gly Leu Pro  Leu Phe Ile Leu Ala  Asn Trp Arg 
    2015                 2020                 2025             


Gly Phe  Ser Gly Gly Gln Arg  Asp Leu Phe Glu Gly  Ile Leu Gln 
    2030                 2035                 2040             


Ala Gly  Ser Thr Ile Val Glu  Asn Leu Arg Thr Tyr  Asn Gln Pro 
    2045                 2050                 2055             


Ala Phe  Val Tyr Ile Pro Lys  Ala Ala Glu Leu Arg  Gly Gly Ala 
    2060                 2065                 2070             


Trp Val  Val Ile Asp Ser Lys  Ile Asn Pro Asp Arg  Ile Glu Cys 
    2075                 2080                 2085             


Tyr Ala  Glu Arg Thr Ala Lys  Gly Asn Val Leu Glu  Pro Gln Gly 
    2090                 2095                 2100             


Leu Ile  Glu Ile Lys Phe Arg  Ser Glu Glu Leu Lys  Glu Cys Met 
    2105                 2110                 2115             


Gly Arg  Leu Asp Pro Glu Leu  Ile Asp Leu Lys Ala  Arg Leu Gln 
    2120                 2125                 2130             


Gly Ala  Asn Gly Ser Leu Ser  Asp Gly Glu Ser Leu  Gln Lys Ser 
    2135                 2140                 2145             


Ile Glu  Ala Arg Lys Lys Gln  Leu Leu Pro Leu Tyr  Thr Gln Ile 
    2150                 2155                 2160             


Ala Val  Arg Phe Ala Glu Leu  His Asp Thr Ser Leu  Arg Met Ala 
    2165                 2170                 2175             


Ala Lys  Gly Val Ile Arg Lys  Val Val Asp Trp Glu  Asp Ser Arg 
    2180                 2185                 2190             


Ser Phe  Phe Tyr Lys Arg Leu  Arg Arg Arg Leu Ser  Glu Asp Val 
    2195                 2200                 2205             


Leu Ala  Lys Glu Ile Arg Gly  Val Ile Gly Glu Lys  Phe Pro His 
    2210                 2215                 2220             


Lys Ser  Ala Ile Glu Leu Ile  Lys Lys Trp Tyr Leu  Ala Ser Glu 
    2225                 2230                 2235             


Ala Ala  Ala Ala Gly Ser Thr  Asp Trp Asp Asp Asp  Asp Ala Phe 
    2240                 2245                 2250             


Val Ala  Trp Arg Glu Asn Pro  Glu Asn Tyr Lys Glu  Tyr Ile Lys 
    2255                 2260                 2265             


Glu Leu  Arg Ala Gln Arg Val  Ser Arg Leu Leu Ser  Asp Val Ala 
    2270                 2275                 2280             


Gly Ser  Ser Ser Asp Leu Gln  Ala Leu Pro Gln Gly  Leu Ser Met 
    2285                 2290                 2295             


Leu Leu  Asp Lys Met Asp Pro  Ser Lys Arg Ala Gln  Phe Ile Glu 
    2300                 2305                 2310             


Glu Val  Met Lys Val Leu Lys  
    2315                 2320 


<210>  2
<211>  670
<212>  PRT
<213>  Arabidopsis thaliana

<400>  2

Met Ala Ala Ala Thr Thr Thr Thr Thr Thr Ser Ser Ser Ile Ser Phe 
1               5                   10                  15      


Ser Thr Lys Pro Ser Pro Ser Ser Ser Lys Ser Pro Leu Pro Ile Ser 
            20                  25                  30          


Arg Phe Ser Leu Pro Phe Ser Leu Asn Pro Asn Lys Ser Ser Ser Ser 
        35                  40                  45              


Ser Arg Arg Arg Gly Ile Lys Ser Ser Ser Pro Ser Ser Ile Ser Ala 
    50                  55                  60                  


Val Leu Asn Thr Thr Thr Asn Val Thr Thr Thr Pro Ser Pro Thr Lys 
65                  70                  75                  80  


Pro Thr Lys Pro Glu Thr Phe Ile Ser Arg Phe Ala Pro Asp Gln Pro 
                85                  90                  95      


Arg Lys Gly Ala Asp Ile Leu Val Glu Ala Leu Glu Arg Gln Gly Val 
            100                 105                 110         


Glu Thr Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu Ile His Gln 
        115                 120                 125             


Ala Leu Thr Arg Ser Ser Ser Ile Arg Asn Val Leu Pro Arg His Glu 
    130                 135                 140                 


Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala Arg Ser Ser Gly Lys 
145                 150                 155                 160 


Pro Gly Ile Cys Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val 
                165                 170                 175     


Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Val Pro Leu Val Ala Ile 
            180                 185                 190         


Thr Gly Gln Val Pro Arg Arg Met Ile Gly Thr Asp Ala Phe Gln Glu 
        195                 200                 205             


Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His Asn Tyr Leu 
    210                 215                 220                 


Val Met Asp Val Glu Asp Ile Pro Arg Ile Ile Glu Glu Ala Phe Phe 
225                 230                 235                 240 


Leu Ala Thr Ser Gly Arg Pro Gly Pro Val Leu Val Asp Val Pro Lys 
                245                 250                 255     


Asp Ile Gln Gln Gln Leu Ala Ile Pro Asn Trp Glu Gln Ala Met Arg 
            260                 265                 270         


Leu Pro Gly Tyr Met Ser Arg Met Pro Lys Pro Pro Glu Asp Ser His 
        275                 280                 285             


Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser Lys Lys Pro Val Leu 
    290                 295                 300                 


Tyr Val Gly Gly Gly Cys Leu Asn Ser Ser Asp Glu Leu Gly Arg Phe 
305                 310                 315                 320 


Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr Leu Met Gly Leu Gly 
                325                 330                 335     


Ser Tyr Pro Cys Asp Asp Glu Leu Ser Leu His Met Leu Gly Met His 
            340                 345                 350         


Gly Thr Val Tyr Ala Asn Tyr Ala Val Glu His Ser Asp Leu Leu Leu 
        355                 360                 365             


Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr Gly Lys Leu Glu Ala 
    370                 375                 380                 


Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp Ile Asp Ser Ala Glu 
385                 390                 395                 400 


Ile Gly Lys Asn Lys Thr Pro His Val Ser Val Cys Gly Asp Val Lys 
                405                 410                 415     


Leu Ala Leu Gln Gly Met Asn Lys Val Leu Glu Asn Arg Ala Glu Glu 
            420                 425                 430         


Leu Lys Leu Asp Phe Gly Val Trp Arg Asn Glu Leu Asn Val Gln Lys 
        435                 440                 445             


Gln Lys Phe Pro Leu Ser Phe Lys Thr Phe Gly Glu Ala Ile Pro Pro 
    450                 455                 460                 


Gln Tyr Ala Ile Lys Val Leu Asp Glu Leu Thr Asp Gly Lys Ala Ile 
465                 470                 475                 480 


Ile Ser Thr Gly Val Gly Gln His Gln Met Trp Ala Ala Gln Phe Tyr 
                485                 490                 495     


Asn Tyr Lys Lys Pro Arg Gln Trp Leu Ser Ser Gly Gly Leu Gly Ala 
            500                 505                 510         


Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala Ser Val Ala Asn Pro 
        515                 520                 525             


Asp Ala Ile Val Val Asp Ile Asp Gly Asp Gly Ser Phe Ile Met Asn 
    530                 535                 540                 


Val Gln Glu Leu Ala Thr Ile Arg Val Glu Asn Leu Pro Val Lys Val 
545                 550                 555                 560 


Leu Leu Leu Asn Asn Gln His Leu Gly Met Val Met Gln Trp Glu Asp 
                565                 570                 575     


Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Phe Leu Gly Asp Pro Ala 
            580                 585                 590         


Gln Glu Asp Glu Ile Phe Pro Asn Met Leu Leu Phe Ala Ala Ala Cys 
        595                 600                 605             


Gly Ile Pro Ala Ala Arg Val Thr Lys Lys Ala Asp Leu Arg Glu Ala 
    610                 615                 620                 


Ile Gln Thr Met Leu Asp Thr Pro Gly Pro Tyr Leu Leu Asp Val Ile 
625                 630                 635                 640 


Cys Pro His Gln Glu His Val Leu Pro Met Ile Pro Ser Gly Gly Thr 
                645                 650                 655     


Phe Asn Asp Val Ile Thr Glu Gly Asp Gly Arg Ile Lys Tyr 
            660                 665                 670 


<210>  3
<211>  446
<212>  PRT
<213>  Oryza sativa

<400>  3

Met Pro Pro Thr Pro Thr Pro Thr Ala Thr Thr Gly Ala Val Ser Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Glu Asn Ala Gly Phe Arg Leu Val Gly His Arg 
            20                  25                  30          


Arg Phe Val Arg Ala Asn Pro Arg Ser Asp Arg Phe Gln Ala Leu Ala 
        35                  40                  45              


Phe His His Val Glu Leu Trp Cys Ala Asp Ala Ala Ser Ala Ala Gly 
    50                  55                  60                  


Arg Phe Ala Phe Ala Leu Gly Ala Pro Leu Ala Ala Arg Ser Asp Leu 
65                  70                  75                  80  


Ser Thr Gly Asn Ser Ala His Ala Ser Leu Leu Leu Arg Ser Ala Ser 
                85                  90                  95      


Val Ala Phe Leu Phe Thr Ala Pro Tyr Gly Gly Asp His Gly Val Gly 
            100                 105                 110         


Ala Asp Ala Ala Thr Thr Ala Ser Ile Pro Ser Phe Ser Pro Gly Ala 
        115                 120                 125             


Ala Arg Arg Phe Ala Ala Asp His Gly Leu Ala Val His Ala Val Ala 
    130                 135                 140                 


Leu Arg Val Ala Asp Ala Ala Asp Ala Phe Arg Ala Ser Val Ala Ala 
145                 150                 155                 160 


Gly Ala Arg Pro Ala Phe Gln Pro Ala Asp Leu Gly Gly Gly Phe Gly 
                165                 170                 175     


Leu Ala Glu Val Glu Leu Tyr Gly Asp Val Val Leu Arg Phe Val Ser 
            180                 185                 190         


His Pro Asp Gly Ala Asp Ala Pro Phe Leu Pro Gly Phe Glu Gly Val 
        195                 200                 205             


Ser Asn Pro Gly Ala Val Asp Tyr Gly Leu Arg Arg Phe Asp His Val 
    210                 215                 220                 


Val Gly Asn Val Pro Glu Leu Ala Pro Val Ala Ala Tyr Ile Ser Gly 
225                 230                 235                 240 


Phe Thr Gly Phe His Glu Phe Ala Glu Phe Thr Ala Glu Asp Val Gly 
                245                 250                 255     


Thr Ala Glu Ser Gly Leu Asn Ser Val Val Leu Ala Asn Asn Ala Glu 
            260                 265                 270         


Thr Val Leu Leu Pro Leu Asn Glu Pro Val His Gly Thr Lys Arg Arg 
        275                 280                 285             


Ser Gln Ile Gln Thr Tyr Leu Asp His His Gly Gly Pro Gly Val Gln 
    290                 295                 300                 


His Ile Ala Leu Ala Ser Asp Asp Val Leu Gly Thr Leu Arg Glu Met 
305                 310                 315                 320 


Arg Ala Arg Ser Ala Met Gly Gly Phe Glu Phe Leu Ala Pro Pro Pro 
                325                 330                 335     


Pro Asn Tyr Tyr Asp Gly Val Arg Arg Arg Ala Gly Asp Val Leu Ser 
            340                 345                 350         


Glu Glu Gln Ile Asn Glu Cys Gln Glu Leu Gly Val Leu Val Asp Arg 
        355                 360                 365             


Asp Asp Gln Gly Val Leu Leu Gln Ile Phe Thr Lys Pro Val Gly Asp 
    370                 375                 380                 


Arg Pro Thr Phe Phe Leu Glu Met Ile Gln Arg Ile Gly Cys Met Glu 
385                 390                 395                 400 


Lys Asp Glu Ser Gly Gln Glu Tyr Gln Lys Gly Gly Cys Gly Gly Phe 
                405                 410                 415     


Gly Lys Gly Asn Phe Ser Glu Leu Phe Lys Ser Ile Glu Glu Tyr Glu 
            420                 425                 430         


Lys Ser Leu Glu Ala Lys Gln Ala Pro Thr Val Gln Gly Ser 
        435                 440                 445     


<210>  4
<211>  510
<212>  PRT
<213>  Triticum aestivum

<400>  4

Met Ala Met Ala Ala Ala Ala Thr Val Ala Ala Ser Ala Ser Ser Ser 
1               5                   10                  15      


Ala Val Ser Leu Asp Arg Ala Ala Pro Ala His Pro Arg Arg Leu Arg 
            20                  25                  30          


Met Pro Ala Ala Arg Ala Ala His Arg Gly Ala Val Arg Leu Trp Gly 
        35                  40                  45              


Pro Arg Gly Ala Ala Ala Arg Ala Thr Ser Val Ala Ala Pro Ala Ala 
    50                  55                  60                  


Pro Ala Gly Ala Glu Glu Val Val Leu Gln Pro Ile Arg Glu Ile Ser 
65                  70                  75                  80  


Gly Ala Val Gln Leu Pro Gly Ser Lys Ser Leu Ser Asn Arg Ile Leu 
                85                  90                  95      


Leu Leu Ser Ala Leu Ser Glu Gly Thr Thr Val Val Asp Asn Leu Leu 
            100                 105                 110         


Asn Ser Glu Asp Val His Tyr Met Leu Glu Ala Leu Glu Ala Leu Gly 
        115                 120                 125             


Leu Ser Val Glu Ala Asp Lys Val Ala Lys Arg Ala Val Val Val Gly 
    130                 135                 140                 


Cys Gly Gly Arg Phe Pro Val Glu Lys Asp Ala Lys Glu Glu Val Lys 
145                 150                 155                 160 


Leu Phe Leu Gly Asn Ala Gly Thr Ala Met Arg Pro Leu Thr Ala Ala 
                165                 170                 175     


Val Val Ala Ala Gly Gly Asn Ala Thr Tyr Val Leu Asp Gly Val Pro 
            180                 185                 190         


Arg Met Arg Glu Arg Pro Ile Gly Asp Leu Val Val Gly Leu Gln Gln 
        195                 200                 205             


Leu Gly Ala Asp Val Asp Cys Phe Leu Gly Thr Asn Cys Pro Pro Val 
    210                 215                 220                 


Arg Ile Asn Gly Lys Gly Gly Leu Pro Gly Gly Lys Val Lys Leu Ser 
225                 230                 235                 240 


Gly Ser Ile Ser Ser Gln Tyr Leu Ser Ser Leu Leu Met Ala Ala Pro 
                245                 250                 255     


Leu Ala Leu Glu Asp Val Glu Ile Glu Ile Ile Asp Lys Leu Ile Ser 
            260                 265                 270         


Val Pro Tyr Val Glu Met Thr Leu Lys Leu Met Glu His Phe Gly Val 
        275                 280                 285             


Thr Ala Glu His Ser Asp Ser Trp Asp Arg Phe Tyr Ile Lys Gly Gly 
    290                 295                 300                 


Gln Lys Tyr Lys Ser Pro Gly Asn Ala Tyr Val Glu Gly Asp Ala Ser 
305                 310                 315                 320 


Ser Ala Ser Tyr Phe Leu Ala Gly Ala Ala Ile Thr Gly Gly Thr Val 
                325                 330                 335     


Thr Val Glu Gly Cys Gly Thr Thr Ser Leu Gln Gly Asp Val Lys Phe 
            340                 345                 350         


Ala Glu Val Leu Glu Met Met Gly Ala Lys Val Thr Trp Thr Asp Thr 
        355                 360                 365             


Ser Val Thr Val Thr Gly Pro Pro Arg Gln Pro Phe Gly Arg Lys His 
    370                 375                 380                 


Leu Lys Ala Val Asp Val Asn Met Asn Lys Met Pro Asp Val Ala Met 
385                 390                 395                 400 


Thr Leu Ala Val Val Ala Leu Phe Ala Asp Gly Pro Thr Ala Ile Arg 
                405                 410                 415     


Asp Val Ala Ser Trp Arg Val Lys Glu Thr Glu Arg Met Val Ala Ile 
            420                 425                 430         


Arg Thr Glu Leu Thr Lys Leu Gly Ala Thr Val Glu Glu Gly Pro Asp 
        435                 440                 445             


Tyr Cys Ile Ile Thr Pro Pro Glu Lys Leu Asn Ile Thr Ala Ile Asp 
    450                 455                 460                 


Thr Tyr Asp Asp His Arg Met Ala Met Ala Phe Ser Leu Ala Ala Cys 
465                 470                 475                 480 


Ala Glu Val Pro Val Thr Ile Arg Asp Pro Gly Cys Thr Arg Lys Thr 
                485                 490                 495     


Phe Pro Asn Tyr Phe Asp Val Leu Ser Thr Phe Val Lys Asn 
            500                 505                 510 


<210>  5
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  6
<211>  1384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCas9

<400>  6

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1370                 1375                 1380             


Lys 
    


<210>  7
<211>  1384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nCas9(D10A)

<400>  7

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1370                 1375                 1380             


Lys 
    


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN

<400>  8

Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
1               5                   10                  15      


<210>  9
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGI

<400>  9

Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu Val 
1               5                   10                  15      


Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile 
            20                  25                  30          


Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu 
        35                  40                  45              


Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr 
    50                  55                  60                  


Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile 
65                  70                  75                  80  


Lys Met Leu 
            


<210>  10
<211>  1737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-APOBEC1-XTEN-nCas9-UGI-NLS fusion protein

<400>  10

Met Pro Lys Lys Lys Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala 
1               5                   10                  15      


Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val 
            20                  25                  30          


Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu 
        35                  40                  45              


Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn 
    50                  55                  60                  


Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu 
65                  70                  75                  80  


Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser 
                85                  90                  95      


Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser 
            100                 105                 110         


Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His 
        115                 120                 125             


His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser 
    130                 135                 140                 


Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp 
145                 150                 155                 160 


Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg 
                165                 170                 175     


Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile 
            180                 185                 190         


Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro 
        195                 200                 205             


Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg 
    210                 215                 220                 


Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Leu Lys Asp Lys Lys 
                245                 250                 255     


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            260                 265                 270         


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
        275                 280                 285             


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
    290                 295                 300                 


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
305                 310                 315                 320 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
                325                 330                 335     


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            340                 345                 350         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        355                 360                 365             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    370                 375                 380                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
385                 390                 395                 400 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                405                 410                 415     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            420                 425                 430         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        435                 440                 445             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    450                 455                 460                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
465                 470                 475                 480 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                485                 490                 495     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            500                 505                 510         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        515                 520                 525             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    530                 535                 540                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
545                 550                 555                 560 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                565                 570                 575     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            580                 585                 590         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        595                 600                 605             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    610                 615                 620                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
625                 630                 635                 640 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                645                 650                 655     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            660                 665                 670         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        675                 680                 685             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    690                 695                 700                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
705                 710                 715                 720 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                725                 730                 735     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            740                 745                 750         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        755                 760                 765             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    770                 775                 780                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
785                 790                 795                 800 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                805                 810                 815     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            820                 825                 830         


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        835                 840                 845             


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
    850                 855                 860                 


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
865                 870                 875                 880 


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
                885                 890                 895     


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
            900                 905                 910         


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
        915                 920                 925             


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
    930                 935                 940                 


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
945                 950                 955                 960 


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
                965                 970                 975     


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
            980                 985                 990         


Val Lys Val Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
        995                 1000                 1005             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1010                 1015                 1020             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1025                 1030                 1035             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1040                 1045                 1050             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1055                 1060                 1065             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1070                 1075                 1080             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1085                 1090                 1095             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1115                 1120                 1125             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1130                 1135                 1140             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1145                 1150                 1155             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1160                 1165                 1170             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1175                 1180                 1185             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1190                 1195                 1200             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1205                 1210                 1215             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1220                 1225                 1230             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1235                 1240                 1245             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1250                 1255                 1260             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1265                 1270                 1275             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1280                 1285                 1290             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1295                 1300                 1305             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1310                 1315                 1320             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1325                 1330                 1335             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1340                 1345                 1350             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1355                 1360                 1365             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1370                 1375                 1380             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1385                 1390                 1395             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1400                 1405                 1410             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1415                 1420                 1425             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1430                 1435                 1440             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1445                 1450                 1455             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1460                 1465                 1470             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1475                 1480                 1485             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1490                 1495                 1500             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1505                 1510                 1515             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1520                 1525                 1530             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1535                 1540                 1545             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1550                 1555                 1560             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1565                 1570                 1575             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1580                 1585                 1590             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1595                 1600                 1605             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1610                 1615                 1620             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys Thr Arg 
    1625                 1630                 1635             


Asp Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1640                 1645                 1650             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1655                 1660                 1665             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1670                 1675                 1680             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1685                 1690                 1695             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1700                 1705                 1710             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1715                 1720                 1725             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1730                 1735         


<210>  11
<211>  1737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS-APOBEC1-XTEN-dCas9-UGI-NLS fusion protein

<400>  11

Met Pro Lys Lys Lys Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala 
1               5                   10                  15      


Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val 
            20                  25                  30          


Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu 
        35                  40                  45              


Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn 
    50                  55                  60                  


Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu 
65                  70                  75                  80  


Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser 
                85                  90                  95      


Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser 
            100                 105                 110         


Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His 
        115                 120                 125             


His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser 
    130                 135                 140                 


Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp 
145                 150                 155                 160 


Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg 
                165                 170                 175     


Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile 
            180                 185                 190         


Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro 
        195                 200                 205             


Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg 
    210                 215                 220                 


Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Leu Lys Asp Lys Lys 
                245                 250                 255     


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            260                 265                 270         


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
        275                 280                 285             


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
    290                 295                 300                 


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
305                 310                 315                 320 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
                325                 330                 335     


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            340                 345                 350         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        355                 360                 365             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    370                 375                 380                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
385                 390                 395                 400 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                405                 410                 415     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            420                 425                 430         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        435                 440                 445             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    450                 455                 460                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
465                 470                 475                 480 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                485                 490                 495     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            500                 505                 510         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        515                 520                 525             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    530                 535                 540                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
545                 550                 555                 560 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                565                 570                 575     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            580                 585                 590         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        595                 600                 605             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    610                 615                 620                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
625                 630                 635                 640 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                645                 650                 655     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            660                 665                 670         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        675                 680                 685             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    690                 695                 700                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
705                 710                 715                 720 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                725                 730                 735     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            740                 745                 750         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        755                 760                 765             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    770                 775                 780                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
785                 790                 795                 800 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                805                 810                 815     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            820                 825                 830         


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        835                 840                 845             


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
    850                 855                 860                 


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
865                 870                 875                 880 


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
                885                 890                 895     


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
            900                 905                 910         


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
        915                 920                 925             


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
    930                 935                 940                 


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
945                 950                 955                 960 


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
                965                 970                 975     


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
            980                 985                 990         


Val Lys Val Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
        995                 1000                 1005             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1010                 1015                 1020             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1025                 1030                 1035             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1040                 1045                 1050             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1055                 1060                 1065             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1070                 1075                 1080             


Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile Val Pro  Gln Ser Phe 
    1085                 1090                 1095             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1115                 1120                 1125             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1130                 1135                 1140             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1145                 1150                 1155             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1160                 1165                 1170             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1175                 1180                 1185             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1190                 1195                 1200             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1205                 1210                 1215             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1220                 1225                 1230             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1235                 1240                 1245             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1250                 1255                 1260             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1265                 1270                 1275             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1280                 1285                 1290             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1295                 1300                 1305             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1310                 1315                 1320             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1325                 1330                 1335             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1340                 1345                 1350             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1355                 1360                 1365             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1370                 1375                 1380             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1385                 1390                 1395             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1400                 1405                 1410             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1415                 1420                 1425             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1430                 1435                 1440             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1445                 1450                 1455             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1460                 1465                 1470             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1475                 1480                 1485             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1490                 1495                 1500             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1505                 1510                 1515             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1520                 1525                 1530             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1535                 1540                 1545             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1550                 1555                 1560             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1565                 1570                 1575             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1580                 1585                 1590             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1595                 1600                 1605             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1610                 1615                 1620             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys Thr Arg 
    1625                 1630                 1635             


Asp Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1640                 1645                 1650             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1655                 1660                 1665             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1670                 1675                 1680             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1685                 1690                 1695             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1700                 1705                 1710             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1715                 1720                 1725             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1730                 1735         


<210>  12
<211>  5214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding NLS-APOBEC1-XTEN-nCas9-UGI-NLS

<400>  12
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggagacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgag      720

acgccaggca cctccgagag cgctacgcct gaacttaagg acaagaagta ctcgatcggc      780

ctcgccatcg ggacgaactc agttggctgg gccgtgatca ccgacgagta caaggtgccc      840

tctaagaagt tcaaggtcct ggggaacacc gaccgccatt ccatcaagaa gaacctcatc      900

ggcgctctcc tgttcgacag cggggagacc gctgaggcta cgaggctcaa gagaaccgct      960

aggcgccggt acacgagaag gaagaacagg atctgctacc tccaagagat tttctccaac     1020

gagatggcca aggttgacga ttcattcttc caccgcctgg aggagtcttt cctcgtggag     1080

gaggataaga agcacgagcg gcatcccatc ttcggcaaca tcgtggacga ggttgcctac     1140

cacgagaagt accctacgat ctaccatctg cggaagaagc tcgtggactc caccgataag     1200

gcggacctca gactgatcta cctcgctctg gcccacatga tcaagttccg cggccatttc     1260

ctgatcgagg gggatctcaa cccagacaac agcgatgttg acaagctgtt catccaactc     1320

gtgcagacct acaaccaact cttcgaggag aacccgatca acgcctctgg cgtggacgcg     1380

aaggctatcc tgtccgcgag gctctcgaag tccaggaggc tggagaacct gatcgctcag     1440

ctcccaggcg agaagaagaa cggcctgttc gggaacctca tcgctctcag cctggggctc     1500

accccgaact tcaagtcgaa cttcgatctc gctgaggacg ccaagctgca actctccaag     1560

gacacctacg acgatgacct cgataacctc ctggcccaga tcggcgatca atacgcggac     1620

ctgttcctcg ctgccaagaa cctgtcggac gccatcctcc tgtcagatat cctccgcgtg     1680

aacaccgaga tcacgaaggc tccactctct gcctccatga tcaagcgcta cgacgagcac     1740

catcaggatc tgaccctcct gaaggcgctg gtccgccaac agctcccgga gaagtacaag     1800

gagattttct tcgatcagtc gaagaacggc tacgctgggt acatcgacgg cggggcctca     1860

caagaggagt tctacaagtt catcaagcca atcctggaga agatggacgg cacggaggag     1920

ctcctggtga agctcaacag ggaggacctc ctgcggaagc agagaacctt cgataacggc     1980

agcatccccc accaaatcca tctcggggag ctgcacgcca tcctgagaag gcaagaggac     2040

ttctaccctt tcctcaagga taaccgggag aagatcgaga agatcctgac cttcagaatc     2100

ccatactacg tcggccctct cgcgcggggg aactcaagat tcgcttggat gacccgcaag     2160

tctgaggaga ccatcacgcc gtggaacttc gaggaggtgg tggacaaggg cgctagcgct     2220

cagtcgttca tcgagaggat gaccaacttc gacaagaacc tgcccaacga gaaggtgctc     2280

cctaagcact cgctcctgta cgagtacttc accgtctaca acgagctcac gaaggtgaag     2340

tacgtcaccg agggcatgcg caagccagcg ttcctgtccg gggagcagaa gaaggctatc     2400

gtggacctcc tgttcaagac caaccggaag gtcacggtta agcaactcaa ggaggactac     2460

ttcaagaaga tcgagtgctt cgattcggtc gagatcagcg gcgttgagga ccgcttcaac     2520

gccagcctcg ggacctacca cgatctcctg aagatcatca aggataagga cttcctggac     2580

aacgaggaga acgaggatat cctggaggac atcgtgctga ccctcacgct gttcgaggac     2640

agggagatga tcgaggagcg cctgaagacg tacgcccatc tcttcgatga caaggtcatg     2700

aagcaactca agcgccggag atacaccggc tgggggaggc tgtcccgcaa gctcatcaac     2760

ggcatccggg acaagcagtc cgggaagacc atcctcgact tcctcaagag cgatggcttc     2820

gccaacagga acttcatgca actgatccac gatgacagcc tcaccttcaa ggaggatatc     2880

caaaaggctc aagtgagcgg ccagggggac tcgctgcacg agcatatcgc gaacctcgct     2940

ggctcccccg cgatcaagaa gggcatcctc cagaccgtga aggttgtgga cgagctcgtg     3000

aaggtcatgg gccggcacaa gcctgagaac atcgtcatcg agatggccag agagaaccaa     3060

accacgcaga aggggcaaaa gaactctagg gagcgcatga agcgcatcga ggagggcatc     3120

aaggagctgg ggtcccaaat cctcaaggag cacccagtgg agaacaccca actgcagaac     3180

gagaagctct acctgtacta cctccagaac ggcagggata tgtacgtgga ccaagagctg     3240

gatatcaacc gcctcagcga ttacgacgtc gatcatatcg ttccccagtc tttcctgaag     3300

gatgactcca tcgacaacaa ggtcctcacc aggtcggaca agaaccgcgg caagtcagat     3360

aacgttccat ctgaggaggt cgttaagaag atgaagaact actggaggca gctcctgaac     3420

gccaagctga tcacgcaaag gaagttcgac aacctcacca aggctgagag aggcgggctc     3480

tcagagctgg acaaggccgg cttcatcaag cggcagctgg tcgagaccag acaaatcacg     3540

aagcacgttg cgcaaatcct cgactctcgg atgaacacga agtacgatga gaacgacaag     3600

ctgatcaggg aggttaaggt gatcaccctg aagtctaagc tcgtctccga cttcaggaag     3660

gatttccagt tctacaaggt tcgcgagatc aacaactacc accatgccca tgacgcttac     3720

ctcaacgctg tggtcggcac cgctctgatc aagaagtacc caaagctgga gtccgagttc     3780

gtgtacgggg actacaaggt ttacgatgtg cgcaagatga tcgccaagtc ggagcaagag     3840

atcggcaagg ctaccgccaa gtacttcttc tactcaaaca tcatgaactt cttcaagacc     3900

gagatcacgc tggccaacgg cgagatccgg aagagaccgc tcatcgagac caacggcgag     3960

acgggggaga tcgtgtggga caagggcagg gatttcgcga ccgtccgcaa ggttctctcc     4020

atgccccagg tgaacatcgt caagaagacc gaggtccaaa cgggcgggtt ctcaaaggag     4080

tctatcctgc ctaagcggaa cagcgacaag ctcatcgcca gaaagaagga ctgggaccca     4140

aagaagtacg gcgggttcga cagccctacc gtggcctact cggtcctggt tgtggcgaag     4200

gttgagaagg gcaagtccaa gaagctcaag agcgtgaagg agctcctggg gatcaccatc     4260

atggagaggt ccagcttcga gaagaaccca atcgacttcc tggaggccaa gggctacaag     4320

gaggtgaaga aggacctgat catcaagctc ccgaagtact ctctcttcga gctggagaac     4380

ggcaggaaga gaatgctggc ttccgctggc gagctccaga aggggaacga gctcgcgctg     4440

ccaagcaagt acgtgaactt cctctacctg gcttcccact acgagaagct caagggcagc     4500

ccggaggaca acgagcaaaa gcagctgttc gtcgagcagc acaagcatta cctcgacgag     4560

atcatcgagc aaatctccga gttcagcaag cgcgtgatcc tcgccgacgc gaacctggat     4620

aaggtcctct ccgcctacaa caagcaccgg gacaagccca tcagagagca agcggagaac     4680

atcatccatc tcttcaccct gacgaacctc ggcgctcctg ctgctttcaa gtacttcgac     4740

accacgatcg atcggaagag atacacctcc acgaaggagg tcctggacgc gaccctcatc     4800

caccagtcga tcaccggcct gtacgagacg aggatcgacc tctcacaact cggcggggat     4860

aagagacccg cagcaaccaa gaaggcaggg caagcaaaga agaagaagac gcgtgactcc     4920

ggcggcagca ccaacctgtc cgacatcatc gagaaggaga cgggcaagca actcgtgatc     4980

caggagagca tcctcatgct gccagaggag gtggaggagg tcatcggcaa caagccagag     5040

tccgacatcc tggtgcacac cgcctacgac gagtccaccg acgagaacgt catgctcctg     5100

accagcgacg ccccagagta caagccatgg gccctcgtca tccaggacag caacggggag     5160

aacaagatca agatgctgtc gggggggagc ccaaagaaga agcggaaggt gtag           5214


<210>  13
<211>  5214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding NLS-APOBEC1-XTEN-dCas9-UGI-NLS

<400>  13
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggagacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgag      720

acgccaggca cctccgagag cgctacgcct gaacttaagg acaagaagta ctcgatcggc      780

ctcgccatcg ggacgaactc agttggctgg gccgtgatca ccgacgagta caaggtgccc      840

tctaagaagt tcaaggtcct ggggaacacc gaccgccatt ccatcaagaa gaacctcatc      900

ggcgctctcc tgttcgacag cggggagacc gctgaggcta cgaggctcaa gagaaccgct      960

aggcgccggt acacgagaag gaagaacagg atctgctacc tccaagagat tttctccaac     1020

gagatggcca aggttgacga ttcattcttc caccgcctgg aggagtcttt cctcgtggag     1080

gaggataaga agcacgagcg gcatcccatc ttcggcaaca tcgtggacga ggttgcctac     1140

cacgagaagt accctacgat ctaccatctg cggaagaagc tcgtggactc caccgataag     1200

gcggacctca gactgatcta cctcgctctg gcccacatga tcaagttccg cggccatttc     1260

ctgatcgagg gggatctcaa cccagacaac agcgatgttg acaagctgtt catccaactc     1320

gtgcagacct acaaccaact cttcgaggag aacccgatca acgcctctgg cgtggacgcg     1380

aaggctatcc tgtccgcgag gctctcgaag tccaggaggc tggagaacct gatcgctcag     1440

ctcccaggcg agaagaagaa cggcctgttc gggaacctca tcgctctcag cctggggctc     1500

accccgaact tcaagtcgaa cttcgatctc gctgaggacg ccaagctgca actctccaag     1560

gacacctacg acgatgacct cgataacctc ctggcccaga tcggcgatca atacgcggac     1620

ctgttcctcg ctgccaagaa cctgtcggac gccatcctcc tgtcagatat cctccgcgtg     1680

aacaccgaga tcacgaaggc tccactctct gcctccatga tcaagcgcta cgacgagcac     1740

catcaggatc tgaccctcct gaaggcgctg gtccgccaac agctcccgga gaagtacaag     1800

gagattttct tcgatcagtc gaagaacggc tacgctgggt acatcgacgg cggggcctca     1860

caagaggagt tctacaagtt catcaagcca atcctggaga agatggacgg cacggaggag     1920

ctcctggtga agctcaacag ggaggacctc ctgcggaagc agagaacctt cgataacggc     1980

agcatccccc accaaatcca tctcggggag ctgcacgcca tcctgagaag gcaagaggac     2040

ttctaccctt tcctcaagga taaccgggag aagatcgaga agatcctgac cttcagaatc     2100

ccatactacg tcggccctct cgcgcggggg aactcaagat tcgcttggat gacccgcaag     2160

tctgaggaga ccatcacgcc gtggaacttc gaggaggtgg tggacaaggg cgctagcgct     2220

cagtcgttca tcgagaggat gaccaacttc gacaagaacc tgcccaacga gaaggtgctc     2280

cctaagcact cgctcctgta cgagtacttc accgtctaca acgagctcac gaaggtgaag     2340

tacgtcaccg agggcatgcg caagccagcg ttcctgtccg gggagcagaa gaaggctatc     2400

gtggacctcc tgttcaagac caaccggaag gtcacggtta agcaactcaa ggaggactac     2460

ttcaagaaga tcgagtgctt cgattcggtc gagatcagcg gcgttgagga ccgcttcaac     2520

gccagcctcg ggacctacca cgatctcctg aagatcatca aggataagga cttcctggac     2580

aacgaggaga acgaggatat cctggaggac atcgtgctga ccctcacgct gttcgaggac     2640

agggagatga tcgaggagcg cctgaagacg tacgcccatc tcttcgatga caaggtcatg     2700

aagcaactca agcgccggag atacaccggc tgggggaggc tgtcccgcaa gctcatcaac     2760

ggcatccggg acaagcagtc cgggaagacc atcctcgact tcctcaagag cgatggcttc     2820

gccaacagga acttcatgca actgatccac gatgacagcc tcaccttcaa ggaggatatc     2880

caaaaggctc aagtgagcgg ccagggggac tcgctgcacg agcatatcgc gaacctcgct     2940

ggctcccccg cgatcaagaa gggcatcctc cagaccgtga aggttgtgga cgagctcgtg     3000

aaggtcatgg gccggcacaa gcctgagaac atcgtcatcg agatggccag agagaaccaa     3060

accacgcaga aggggcaaaa gaactctagg gagcgcatga agcgcatcga ggagggcatc     3120

aaggagctgg ggtcccaaat cctcaaggag cacccagtgg agaacaccca actgcagaac     3180

gagaagctct acctgtacta cctccagaac ggcagggata tgtacgtgga ccaagagctg     3240

gatatcaacc gcctcagcga ttacgacgtc gatgctatcg ttccccagtc tttcctgaag     3300

gatgactcca tcgacaacaa ggtcctcacc aggtcggaca agaaccgcgg caagtcagat     3360

aacgttccat ctgaggaggt cgttaagaag atgaagaact actggaggca gctcctgaac     3420

gccaagctga tcacgcaaag gaagttcgac aacctcacca aggctgagag aggcgggctc     3480

tcagagctgg acaaggccgg cttcatcaag cggcagctgg tcgagaccag acaaatcacg     3540

aagcacgttg cgcaaatcct cgactctcgg atgaacacga agtacgatga gaacgacaag     3600

ctgatcaggg aggttaaggt gatcaccctg aagtctaagc tcgtctccga cttcaggaag     3660

gatttccagt tctacaaggt tcgcgagatc aacaactacc accatgccca tgacgcttac     3720

ctcaacgctg tggtcggcac cgctctgatc aagaagtacc caaagctgga gtccgagttc     3780

gtgtacgggg actacaaggt ttacgatgtg cgcaagatga tcgccaagtc ggagcaagag     3840

atcggcaagg ctaccgccaa gtacttcttc tactcaaaca tcatgaactt cttcaagacc     3900

gagatcacgc tggccaacgg cgagatccgg aagagaccgc tcatcgagac caacggcgag     3960

acgggggaga tcgtgtggga caagggcagg gatttcgcga ccgtccgcaa ggttctctcc     4020

atgccccagg tgaacatcgt caagaagacc gaggtccaaa cgggcgggtt ctcaaaggag     4080

tctatcctgc ctaagcggaa cagcgacaag ctcatcgcca gaaagaagga ctgggaccca     4140

aagaagtacg gcgggttcga cagccctacc gtggcctact cggtcctggt tgtggcgaag     4200

gttgagaagg gcaagtccaa gaagctcaag agcgtgaagg agctcctggg gatcaccatc     4260

atggagaggt ccagcttcga gaagaaccca atcgacttcc tggaggccaa gggctacaag     4320

gaggtgaaga aggacctgat catcaagctc ccgaagtact ctctcttcga gctggagaac     4380

ggcaggaaga gaatgctggc ttccgctggc gagctccaga aggggaacga gctcgcgctg     4440

ccaagcaagt acgtgaactt cctctacctg gcttcccact acgagaagct caagggcagc     4500

ccggaggaca acgagcaaaa gcagctgttc gtcgagcagc acaagcatta cctcgacgag     4560

atcatcgagc aaatctccga gttcagcaag cgcgtgatcc tcgccgacgc gaacctggat     4620

aaggtcctct ccgcctacaa caagcaccgg gacaagccca tcagagagca agcggagaac     4680

atcatccatc tcttcaccct gacgaacctc ggcgctcctg ctgctttcaa gtacttcgac     4740

accacgatcg atcggaagag atacacctcc acgaaggagg tcctggacgc gaccctcatc     4800

caccagtcga tcaccggcct gtacgagacg aggatcgacc tctcacaact cggcggggat     4860

aagagacccg cagcaaccaa gaaggcaggg caagcaaaga agaagaagac gcgtgactcc     4920

ggcggcagca ccaacctgtc cgacatcatc gagaaggaga cgggcaagca actcgtgatc     4980

caggagagca tcctcatgct gccagaggag gtggaggagg tcatcggcaa caagccagag     5040

tccgacatcc tggtgcacac cgcctacgac gagtccaccg acgagaacgt catgctcctg     5100

accagcgacg ccccagagta caagccatgg gccctcgtca tccaggacag caacggggag     5160

aacaagatca agatgctgtc gggggggagc ccaaagaaga agcggaaggt gtag           5214


<210>  14
<211>  2327
<212>  PRT
<213>  Oryza sativa

<400>  14

Met Thr Ser Thr His Val Ala Thr Leu Gly Val Gly Ala Gln Ala Pro 
1               5                   10                  15      


Pro Arg His Gln Lys Lys Ser Ala Gly Thr Ala Phe Val Ser Ser Gly 
            20                  25                  30          


Ser Ser Arg Pro Ser Tyr Arg Lys Asn Gly Gln Arg Thr Arg Ser Leu 
        35                  40                  45              


Arg Glu Glu Ser Asn Gly Gly Val Ser Asp Ser Lys Lys Leu Asn His 
    50                  55                  60                  


Ser Ile Arg Gln Gly Leu Ala Gly Ile Ile Asp Leu Pro Asn Asp Ala 
65                  70                  75                  80  


Ala Ser Glu Val Asp Ile Ser His Gly Ser Glu Asp Pro Arg Gly Pro 
                85                  90                  95      


Thr Val Pro Gly Ser Tyr Gln Met Asn Gly Ile Ile Asn Glu Thr His 
            100                 105                 110         


Asn Gly Arg His Ala Ser Val Ser Lys Val Val Glu Phe Cys Thr Ala 
        115                 120                 125             


Leu Gly Gly Lys Thr Pro Ile His Ser Val Leu Val Ala Asn Asn Gly 
    130                 135                 140                 


Met Ala Ala Ala Lys Phe Met Arg Ser Val Arg Thr Trp Ala Asn Asp 
145                 150                 155                 160 


Thr Phe Gly Ser Glu Lys Ala Ile Gln Leu Ile Ala Met Ala Thr Pro 
                165                 170                 175     


Glu Asp Leu Arg Ile Asn Ala Glu His Ile Arg Ile Ala Asp Gln Phe 
            180                 185                 190         


Val Glu Val Pro Gly Gly Thr Asn Asn Asn Asn Tyr Ala Asn Val Gln 
        195                 200                 205             


Leu Ile Val Glu Ile Ala Glu Arg Thr Gly Val Ser Ala Val Trp Pro 
    210                 215                 220                 


Gly Trp Gly His Ala Ser Glu Asn Pro Glu Leu Pro Asp Ala Leu Thr 
225                 230                 235                 240 


Ala Lys Gly Ile Val Phe Leu Gly Pro Pro Ala Ser Ser Met His Ala 
                245                 250                 255     


Leu Gly Asp Lys Val Gly Ser Ala Leu Ile Ala Gln Ala Ala Gly Val 
            260                 265                 270         


Pro Thr Leu Ala Trp Ser Gly Ser His Val Glu Val Pro Leu Glu Cys 
        275                 280                 285             


Cys Leu Asp Ser Ile Pro Asp Glu Met Tyr Arg Lys Ala Cys Val Thr 
    290                 295                 300                 


Thr Thr Glu Glu Ala Val Ala Ser Cys Gln Val Val Gly Tyr Pro Ala 
305                 310                 315                 320 


Met Ile Lys Ala Ser Trp Gly Gly Gly Gly Lys Gly Ile Arg Lys Val 
                325                 330                 335     


His Asn Asp Asp Glu Val Arg Thr Leu Phe Lys Gln Val Gln Gly Glu 
            340                 345                 350         


Val Pro Gly Ser Pro Ile Phe Ile Met Arg Leu Ala Ala Gln Ser Arg 
        355                 360                 365             


His Leu Glu Val Gln Leu Leu Cys Asp Gln Tyr Gly Asn Val Ala Ala 
    370                 375                 380                 


Leu His Ser Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile 
385                 390                 395                 400 


Glu Glu Gly Pro Val Thr Val Ala Pro Arg Glu Thr Val Lys Glu Leu 
                405                 410                 415     


Glu Gln Ala Ala Arg Arg Leu Ala Lys Ala Val Gly Tyr Val Gly Ala 
            420                 425                 430         


Ala Thr Val Glu Tyr Leu Tyr Ser Met Glu Thr Gly Glu Tyr Tyr Phe 
        435                 440                 445             


Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Val Thr Glu Trp 
    450                 455                 460                 


Ile Ala Glu Val Asn Leu Pro Ala Ala Gln Val Ala Val Gly Met Gly 
465                 470                 475                 480 


Ile Pro Leu Trp Gln Ile Pro Glu Ile Arg Arg Phe Tyr Gly Met Asn 
                485                 490                 495     


His Gly Gly Gly Tyr Asp Leu Trp Arg Lys Thr Ala Ala Leu Ala Thr 
            500                 505                 510         


Pro Phe Asn Phe Asp Glu Val Asp Ser Lys Trp Pro Lys Gly His Cys 
        515                 520                 525             


Val Ala Val Arg Ile Thr Ser Glu Asp Pro Asp Asp Gly Phe Lys Pro 
    530                 535                 540                 


Thr Gly Gly Lys Val Lys Glu Ile Ser Phe Lys Ser Lys Pro Asn Val 
545                 550                 555                 560 


Trp Ala Tyr Phe Ser Val Lys Ser Gly Gly Gly Ile His Glu Phe Ala 
                565                 570                 575     


Asp Ser Gln Phe Gly His Val Phe Ala Tyr Gly Thr Thr Arg Ser Ala 
            580                 585                 590         


Ala Ile Thr Thr Met Ala Leu Ala Leu Lys Glu Val Gln Ile Arg Gly 
        595                 600                 605             


Glu Ile His Ser Asn Val Asp Tyr Thr Val Asp Leu Leu Asn Ala Ser 
    610                 615                 620                 


Asp Phe Arg Glu Asn Lys Ile His Thr Gly Trp Leu Asp Thr Arg Ile 
625                 630                 635                 640 


Ala Met Arg Val Gln Ala Glu Arg Pro Pro Trp Tyr Ile Ser Val Val 
                645                 650                 655     


Gly Gly Ala Leu Tyr Lys Thr Val Thr Ala Asn Thr Ala Thr Val Ser 
            660                 665                 670         


Asp Tyr Val Gly Tyr Leu Thr Lys Gly Gln Ile Pro Pro Lys His Ile 
        675                 680                 685             


Ser Leu Val Tyr Thr Thr Val Ala Leu Asn Ile Asp Gly Lys Lys Tyr 
    690                 695                 700                 


Thr Ile Asp Thr Val Arg Ser Gly His Gly Ser Tyr Arg Leu Arg Met 
705                 710                 715                 720 


Asn Gly Ser Thr Val Asp Ala Asn Val Gln Ile Leu Cys Asp Gly Gly 
                725                 730                 735     


Leu Leu Met Gln Leu Asp Gly Asn Ser His Val Ile Tyr Ala Glu Glu 
            740                 745                 750         


Glu Ala Ser Gly Thr Arg Leu Leu Ile Asp Gly Lys Thr Cys Met Leu 
        755                 760                 765             


Gln Asn Asp His Asp Pro Ser Lys Leu Leu Ala Glu Thr Pro Cys Lys 
    770                 775                 780                 


Leu Leu Arg Phe Leu Val Ala Asp Gly Ala His Val Asp Ala Asp Val 
785                 790                 795                 800 


Pro Tyr Ala Glu Val Glu Val Met Lys Met Cys Met Pro Leu Leu Ser 
                805                 810                 815     


Pro Ala Ser Gly Val Ile His Val Val Met Ser Glu Gly Gln Ala Met 
            820                 825                 830         


Gln Ala Gly Asp Leu Ile Ala Arg Leu Asp Leu Asp Asp Pro Ser Ala 
        835                 840                 845             


Val Lys Arg Ala Glu Pro Phe Glu Asp Thr Phe Pro Gln Met Gly Leu 
    850                 855                 860                 


Pro Ile Ala Ala Ser Gly Gln Val His Lys Leu Cys Ala Ala Ser Leu 
865                 870                 875                 880 


Asn Ala Cys Arg Met Ile Leu Ala Gly Tyr Glu His Asp Ile Asp Lys 
                885                 890                 895     


Val Val Pro Glu Leu Val Tyr Cys Leu Asp Thr Pro Glu Leu Pro Phe 
            900                 905                 910         


Leu Gln Trp Glu Glu Leu Met Ser Val Leu Ala Thr Arg Leu Pro Arg 
        915                 920                 925             


Asn Leu Lys Ser Glu Leu Glu Gly Lys Tyr Glu Glu Tyr Lys Val Lys 
    930                 935                 940                 


Phe Asp Ser Gly Ile Ile Asn Asp Phe Pro Ala Asn Met Leu Arg Val 
945                 950                 955                 960 


Ile Ile Glu Glu Asn Leu Ala Cys Gly Ser Glu Lys Glu Lys Ala Thr 
                965                 970                 975     


Asn Glu Arg Leu Val Glu Pro Leu Met Ser Leu Leu Lys Ser Tyr Glu 
            980                 985                 990         


Gly Gly Arg Glu Ser His Ala His  Phe Val Val Lys Ser  Leu Phe Glu 
        995                 1000                 1005             


Glu Tyr  Leu Tyr Val Glu Glu  Leu Phe Ser Asp Gly  Ile Gln Ser 
    1010                 1015                 1020             


Asp Val  Ile Glu Arg Leu Arg  Leu Gln His Ser Lys  Asp Leu Gln 
    1025                 1030                 1035             


Lys Val  Val Asp Ile Val Leu  Ser His Gln Ser Val  Arg Asn Lys 
    1040                 1045                 1050             


Thr Lys  Leu Ile Leu Lys Leu  Met Glu Ser Leu Val  Tyr Pro Asn 
    1055                 1060                 1065             


Pro Ala  Ala Tyr Arg Asp Gln  Leu Ile Arg Phe Ser  Ser Leu Asn 
    1070                 1075                 1080             


His Lys  Ala Tyr Tyr Lys Leu  Ala Leu Lys Ala Ser  Glu Leu Leu 
    1085                 1090                 1095             


Glu Gln  Thr Lys Leu Ser Glu  Leu Arg Ala Arg Ile  Ala Arg Ser 
    1100                 1105                 1110             


Leu Ser  Glu Leu Glu Met Phe  Thr Glu Glu Ser Lys  Gly Leu Ser 
    1115                 1120                 1125             


Met His  Lys Arg Glu Ile Ala  Ile Lys Glu Ser Met  Glu Asp Leu 
    1130                 1135                 1140             


Val Thr  Ala Pro Leu Pro Val  Glu Asp Ala Leu Ile  Ser Leu Phe 
    1145                 1150                 1155             


Asp Cys  Ser Asp Thr Thr Val  Gln Gln Arg Val Ile  Glu Thr Tyr 
    1160                 1165                 1170             


Ile Ala  Arg Leu Tyr Gln Pro  His Leu Val Lys Asp  Ser Ile Lys 
    1175                 1180                 1185             


Met Lys  Trp Ile Glu Ser Gly  Val Ile Ala Leu Trp  Glu Phe Pro 
    1190                 1195                 1200             


Glu Gly  His Phe Asp Ala Arg  Asn Gly Gly Ala Val  Leu Gly Asp 
    1205                 1210                 1215             


Lys Arg  Trp Gly Ala Met Val  Ile Val Lys Ser Leu  Glu Ser Leu 
    1220                 1225                 1230             


Ser Met  Ala Ile Arg Phe Ala  Leu Lys Glu Thr Ser  His Tyr Thr 
    1235                 1240                 1245             


Ser Ser  Glu Gly Asn Met Met  His Ile Ala Leu Leu  Gly Ala Asp 
    1250                 1255                 1260             


Asn Lys  Met His Ile Ile Gln  Glu Ser Gly Asp Asp  Ala Asp Arg 
    1265                 1270                 1275             


Ile Ala  Lys Leu Pro Leu Ile  Leu Lys Asp Asn Val  Thr Asp Leu 
    1280                 1285                 1290             


His Ala  Ser Gly Val Lys Thr  Ile Ser Phe Ile Val  Gln Arg Asp 
    1295                 1300                 1305             


Glu Ala  Arg Met Thr Met Arg  Arg Thr Phe Leu Trp  Ser Asp Glu 
    1310                 1315                 1320             


Lys Leu  Ser Tyr Glu Glu Glu  Pro Ile Leu Arg His  Val Glu Pro 
    1325                 1330                 1335             


Pro Leu  Ser Ala Leu Leu Glu  Leu Asp Lys Leu Lys  Val Lys Gly 
    1340                 1345                 1350             


Tyr Asn  Glu Met Lys Tyr Thr  Pro Ser Arg Asp Arg  Gln Trp His 
    1355                 1360                 1365             


Ile Tyr  Thr Leu Arg Asn Thr  Glu Asn Pro Lys Met  Leu His Arg 
    1370                 1375                 1380             


Val Phe  Phe Arg Thr Leu Val  Arg Gln Pro Ser Val  Ser Asn Lys 
    1385                 1390                 1395             


Phe Ser  Ser Gly Gln Ile Gly  Asp Met Glu Val Gly  Ser Ala Glu 
    1400                 1405                 1410             


Glu Pro  Leu Ser Phe Thr Ser  Thr Ser Ile Leu Arg  Ser Leu Met 
    1415                 1420                 1425             


Thr Ala  Ile Glu Glu Leu Glu  Leu His Ala Ile Arg  Thr Gly His 
    1430                 1435                 1440             


Ser His  Met Tyr Leu His Val  Leu Lys Glu Gln Lys  Leu Leu Asp 
    1445                 1450                 1455             


Leu Val  Pro Val Ser Gly Asn  Thr Val Leu Asp Val  Gly Gln Asp 
    1460                 1465                 1470             


Glu Ala  Thr Ala Tyr Ser Leu  Leu Lys Glu Met Ala  Met Lys Ile 
    1475                 1480                 1485             


His Glu  Leu Val Gly Ala Arg  Met His His Leu Ser  Val Cys Gln 
    1490                 1495                 1500             


Trp Glu  Val Lys Leu Lys Leu  Asp Cys Asp Gly Pro  Ala Ser Gly 
    1505                 1510                 1515             


Thr Trp  Arg Ile Val Thr Thr  Asn Val Thr Ser His  Thr Cys Thr 
    1520                 1525                 1530             


Val Asp  Ile Tyr Arg Glu Met  Glu Asp Lys Glu Ser  Arg Lys Leu 
    1535                 1540                 1545             


Val Tyr  His Pro Ala Thr Pro  Ala Ala Gly Pro Leu  His Gly Val 
    1550                 1555                 1560             


Ala Leu  Asn Asn Pro Tyr Gln  Pro Leu Ser Val Ile  Asp Leu Lys 
    1565                 1570                 1575             


Arg Cys  Ser Ala Arg Asn Asn  Arg Thr Thr Tyr Cys  Tyr Asp Phe 
    1580                 1585                 1590             


Pro Leu  Ala Phe Glu Thr Ala  Val Arg Lys Ser Trp  Ser Ser Ser 
    1595                 1600                 1605             


Thr Ser  Gly Ala Ser Lys Gly  Val Glu Asn Ala Gln  Cys Tyr Val 
    1610                 1615                 1620             


Lys Ala  Thr Glu Leu Val Phe  Ala Asp Lys His Gly  Ser Trp Gly 
    1625                 1630                 1635             


Thr Pro  Leu Val Gln Met Asp  Arg Pro Ala Gly Leu  Asn Asp Ile 
    1640                 1645                 1650             


Gly Met  Val Ala Trp Thr Leu  Lys Met Ser Thr Pro  Glu Phe Pro 
    1655                 1660                 1665             


Ser Gly  Arg Glu Ile Ile Val  Val Ala Asn Asp Ile  Thr Phe Arg 
    1670                 1675                 1680             


Ala Gly  Ser Phe Gly Pro Arg  Glu Asp Ala Phe Phe  Glu Ala Val 
    1685                 1690                 1695             


Thr Asn  Leu Ala Cys Glu Lys  Lys Leu Pro Leu Ile  Tyr Leu Ala 
    1700                 1705                 1710             


Ala Asn  Ser Gly Ala Arg Ile  Gly Ile Ala Asp Glu  Val Lys Ser 
    1715                 1720                 1725             


Cys Phe  Arg Val Gly Trp Ser  Asp Asp Gly Ser Pro  Glu Arg Gly 
    1730                 1735                 1740             


Phe Gln  Tyr Ile Tyr Leu Ser  Glu Glu Asp Tyr Ala  Arg Ile Gly 
    1745                 1750                 1755             


Thr Ser  Val Ile Ala His Lys  Met Gln Leu Asp Ser  Gly Glu Ile 
    1760                 1765                 1770             


Arg Trp  Val Ile Asp Ser Val  Val Gly Lys Glu Asp  Gly Leu Gly 
    1775                 1780                 1785             


Val Glu  Asn Ile His Gly Ser  Ala Ala Ile Ala Ser  Ala Tyr Ser 
    1790                 1795                 1800             


Arg Ala  Tyr Lys Glu Thr Phe  Thr Leu Thr Phe Val  Thr Gly Arg 
    1805                 1810                 1815             


Thr Val  Gly Ile Gly Ala Tyr  Leu Ala Arg Leu Gly  Ile Arg Cys 
    1820                 1825                 1830             


Ile Gln  Arg Leu Asp Gln Pro  Ile Ile Leu Thr Gly  Tyr Ser Ala 
    1835                 1840                 1845             


Leu Asn  Lys Leu Leu Gly Arg  Glu Val Tyr Ser Ser  His Met Gln 
    1850                 1855                 1860             


Leu Gly  Gly Pro Lys Ile Met  Ala Thr Asn Gly Val  Val His Leu 
    1865                 1870                 1875             


Thr Val  Ser Asp Asp Leu Glu  Gly Val Ser Asn Ile  Leu Arg Trp 
    1880                 1885                 1890             


Leu Ser  Tyr Val Pro Ala Tyr  Ile Gly Gly Pro Leu  Pro Val Thr 
    1895                 1900                 1905             


Thr Pro  Leu Asp Pro Pro Asp  Arg Pro Val Ala Tyr  Ile Pro Glu 
    1910                 1915                 1920             


Asn Ser  Cys Asp Pro Arg Ala  Ala Ile Arg Gly Val  Asp Asp Ser 
    1925                 1930                 1935             


Gln Gly  Lys Trp Leu Gly Gly  Met Phe Asp Lys Asp  Ser Phe Val 
    1940                 1945                 1950             


Glu Thr  Phe Glu Gly Trp Ala  Lys Thr Val Val Thr  Gly Arg Ala 
    1955                 1960                 1965             


Lys Leu  Gly Gly Ile Pro Val  Gly Val Ile Ala Val  Glu Thr Gln 
    1970                 1975                 1980             


Thr Met  Met Gln Thr Ile Pro  Ala Asp Pro Gly Gln  Leu Asp Ser 
    1985                 1990                 1995             


Arg Glu  Gln Ser Val Pro Arg  Ala Gly Gln Val Trp  Phe Pro Asp 
    2000                 2005                 2010             


Ser Ala  Thr Lys Thr Ala Gln  Ala Leu Leu Asp Phe  Asn Arg Glu 
    2015                 2020                 2025             


Gly Leu  Pro Leu Phe Ile Leu  Ala Asn Trp Arg Gly  Phe Ser Gly 
    2030                 2035                 2040             


Gly Gln  Arg Asp Leu Phe Glu  Gly Ile Leu Gln Ala  Gly Ser Thr 
    2045                 2050                 2055             


Ile Val  Glu Asn Leu Arg Thr  Tyr Asn Gln Pro Ala  Phe Val Tyr 
    2060                 2065                 2070             


Ile Pro  Met Ala Ala Glu Leu  Arg Gly Gly Ala Trp  Val Val Val 
    2075                 2080                 2085             


Asp Ser  Lys Ile Asn Pro Asp  Arg Ile Glu Cys Tyr  Ala Glu Arg 
    2090                 2095                 2100             


Thr Ala  Lys Gly Asn Val Leu  Glu Pro Gln Gly Leu  Ile Glu Ile 
    2105                 2110                 2115             


Lys Phe  Arg Ser Glu Glu Leu  Gln Asp Cys Met Ser  Arg Leu Asp 
    2120                 2125                 2130             


Pro Thr  Leu Ile Asp Leu Lys  Ala Lys Leu Glu Val  Ala Asn Lys 
    2135                 2140                 2145             


Asn Gly  Ser Ala Asp Thr Lys  Ser Leu Gln Glu Asn  Ile Glu Ala 
    2150                 2155                 2160             


Arg Thr  Lys Gln Leu Met Pro  Leu Tyr Thr Gln Ile  Ala Ile Arg 
    2165                 2170                 2175             


Phe Ala  Glu Leu His Asp Thr  Ser Leu Arg Met Ala  Ala Lys Gly 
    2180                 2185                 2190             


Val Ile  Lys Lys Val Val Asp  Trp Glu Glu Ser Arg  Ser Phe Phe 
    2195                 2200                 2205             


Tyr Lys  Arg Leu Arg Arg Arg  Ile Ser Glu Asp Val  Leu Ala Lys 
    2210                 2215                 2220             


Glu Ile  Arg Ala Val Ala Gly  Glu Gln Phe Ser His  Gln Pro Ala 
    2225                 2230                 2235             


Ile Glu  Leu Ile Lys Lys Trp  Tyr Ser Ala Ser His  Ala Ala Glu 
    2240                 2245                 2250             


Trp Asp  Asp Asp Asp Ala Phe  Val Ala Trp Met Asp  Asn Pro Glu 
    2255                 2260                 2265             


Asn Tyr  Lys Asp Tyr Ile Gln  Tyr Leu Lys Ala Gln  Arg Val Ser 
    2270                 2275                 2280             


Gln Ser  Leu Ser Ser Leu Ser  Asp Ser Ser Ser Asp  Leu Gln Ala 
    2285                 2290                 2295             


Leu Pro  Gln Gly Leu Ser Met  Leu Leu Asp Lys Met  Asp Pro Ser 
    2300                 2305                 2310             


Arg Arg  Ala Gln Leu Val Glu  Glu Ile Arg Lys Val  Leu Gly 
    2315                 2320                 2325         


<210>  15
<211>  2311
<212>  PRT
<213>  Triticum aestivum

<400>  15

Met Gly Ser Thr His Leu Pro Ile Val Gly Phe Asn Ala Ser Thr Thr 
1               5                   10                  15      


Pro Ser Leu Ser Thr Ile Arg Pro Val Asn Ser Ala Gly Ala Ala Phe 
            20                  25                  30          


Gln Pro Ser Ala Pro Ser Arg Thr Ser Lys Lys Lys Ser Arg Arg Val 
        35                  40                  45              


Gln Ser Leu Arg Asp Gly Gly Asp Gly Gly Val Ser Asp Pro Asn Gln 
    50                  55                  60                  


Ser Ile Arg Gln Gly Leu Ala Gly Ile Ile Asp Leu Pro Lys Glu Gly 
65                  70                  75                  80  


Thr Ser Ala Pro Glu Val Asp Ile Ser His Gly Ser Glu Glu Pro Arg 
                85                  90                  95      


Gly Ser Tyr Gln Met Asn Gly Ile Leu Asn Glu Ala His Asn Gly Arg 
            100                 105                 110         


His Ala Ser Leu Ser Lys Val Val Glu Phe Cys Val Ala Leu Gly Gly 
        115                 120                 125             


Lys Thr Pro Ile His Ser Val Leu Val Ala Asn Asn Gly Met Ala Ala 
    130                 135                 140                 


Ala Lys Phe Met Arg Ser Val Arg Thr Trp Ala Asn Glu Thr Phe Gly 
145                 150                 155                 160 


Ser Glu Lys Ala Ile Gln Leu Ile Ala Met Ala Thr Pro Glu Asp Met 
                165                 170                 175     


Arg Ile Asn Ala Glu His Ile Arg Ile Ala Asp Gln Phe Val Glu Val 
            180                 185                 190         


Pro Gly Gly Thr Asn Asn Asn Asn Tyr Ala Asn Val Gln Leu Ile Val 
        195                 200                 205             


Glu Ile Ala Val Arg Thr Gly Val Ser Ala Val Trp Pro Gly Trp Gly 
    210                 215                 220                 


His Ala Ser Glu Asn Pro Glu Leu Pro Asp Ala Leu Asn Ala Asn Gly 
225                 230                 235                 240 


Ile Val Phe Leu Gly Pro Pro Ser Ser Ser Met Asn Ala Leu Gly Asp 
                245                 250                 255     


Lys Val Gly Ser Ala Leu Ile Ala Gln Ala Ala Gly Val Pro Thr Leu 
            260                 265                 270         


Pro Trp Ser Gly Ser Gln Val Glu Ile Pro Leu Glu Val Cys Leu Asp 
        275                 280                 285             


Ser Ile Pro Ala Glu Met Tyr Arg Lys Ala Cys Val Ser Thr Thr Glu 
    290                 295                 300                 


Glu Ala Leu Ala Ser Cys Gln Met Ile Gly Tyr Pro Ala Met Ile Lys 
305                 310                 315                 320 


Ala Ser Trp Gly Gly Gly Gly Lys Gly Ile Arg Lys Val Asn Asn Asp 
                325                 330                 335     


Asp Asp Val Arg Ala Leu Phe Lys Gln Val Gln Gly Glu Val Pro Gly 
            340                 345                 350         


Ser Pro Ile Phe Ile Met Arg Leu Ala Ser Gln Ser Arg His Leu Glu 
        355                 360                 365             


Val Gln Leu Leu Cys Asp Gln Tyr Gly Asn Val Ala Ala Leu His Ser 
    370                 375                 380                 


Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Gly 
385                 390                 395                 400 


Pro Val Thr Val Ala Pro Arg Glu Thr Val Lys Glu Leu Glu Gln Ala 
                405                 410                 415     


Ala Arg Arg Leu Ala Lys Ala Val Gly Tyr Val Gly Ala Ala Thr Val 
            420                 425                 430         


Glu Tyr Leu Tyr Ser Met Glu Thr Gly Glu Tyr Tyr Phe Leu Glu Leu 
        435                 440                 445             


Asn Pro Arg Leu Gln Val Glu His Pro Val Thr Glu Trp Ile Ala Glu 
    450                 455                 460                 


Val Asn Leu Pro Ala Ala Gln Val Ala Val Gly Met Gly Ile Pro Leu 
465                 470                 475                 480 


Trp Gln Val Pro Glu Ile Arg Arg Phe Tyr Gly Met Asp Asn Gly Gly 
                485                 490                 495     


Gly Tyr Asp Ile Trp Arg Lys Thr Ala Ala Leu Ala Thr Pro Phe Asn 
            500                 505                 510         


Phe Asp Glu Val Asp Ser Gln Trp Pro Lys Gly His Cys Val Ala Val 
        515                 520                 525             


Arg Ile Thr Ser Glu Asp Pro Asp Asp Gly Phe Lys Pro Thr Gly Gly 
    530                 535                 540                 


Lys Val Lys Glu Ile Ser Phe Lys Ser Lys Pro Asn Val Trp Ala Tyr 
545                 550                 555                 560 


Phe Ser Val Lys Ser Gly Gly Gly Ile His Glu Phe Ala Asp Ser Gln 
                565                 570                 575     


Phe Gly His Val Phe Ala Tyr Gly Val Ser Arg Ala Ala Ala Ile Thr 
            580                 585                 590         


Asn Met Ser Leu Ala Leu Lys Glu Ile Gln Ile Arg Gly Glu Ile His 
        595                 600                 605             


Ser Asn Val Asp Tyr Thr Val Asp Leu Leu Asn Ala Ser Asp Phe Lys 
    610                 615                 620                 


Glu Asn Arg Ile His Thr Gly Trp Leu Asp Asn Arg Ile Ala Met Arg 
625                 630                 635                 640 


Val Gln Ala Glu Arg Pro Pro Trp Tyr Ile Ser Val Val Gly Gly Ala 
                645                 650                 655     


Leu Tyr Lys Thr Ile Thr Ser Asn Thr Asp Thr Val Ser Glu Tyr Val 
            660                 665                 670         


Ser Tyr Leu Val Lys Gly Gln Ile Pro Pro Lys His Ile Ser Leu Val 
        675                 680                 685             


His Ser Thr Val Ser Leu Asn Ile Glu Glu Ser Lys Tyr Thr Ile Glu 
    690                 695                 700                 


Thr Ile Arg Ser Gly Gln Gly Ser Tyr Arg Leu Arg Met Asn Gly Ser 
705                 710                 715                 720 


Val Ile Glu Ala Asn Val Gln Thr Leu Cys Asp Gly Gly Leu Leu Met 
                725                 730                 735     


Gln Leu Asp Gly Asn Ser His Val Ile Tyr Ala Glu Glu Glu Ala Gly 
            740                 745                 750         


Gly Thr Arg Leu Leu Ile Asp Gly Lys Thr Cys Leu Leu Gln Asn Asp 
        755                 760                 765             


His Asp Pro Ser Arg Leu Leu Ala Glu Thr Pro Cys Lys Leu Leu Arg 
    770                 775                 780                 


Phe Leu Val Ala Asp Gly Ala His Val Glu Ala Asp Val Pro Tyr Ala 
785                 790                 795                 800 


Glu Val Glu Val Met Lys Met Cys Met Pro Leu Leu Ser Pro Ala Ala 
                805                 810                 815     


Gly Val Ile Asn Val Leu Leu Ser Glu Gly Gln Pro Met Gln Ala Gly 
            820                 825                 830         


Asp Leu Ile Ala Arg Leu Asp Leu Asp Asp Pro Ser Ala Val Lys Arg 
        835                 840                 845             


Ala Glu Pro Phe Asn Gly Ser Phe Pro Glu Met Ser Leu Pro Ile Ala 
    850                 855                 860                 


Ala Ser Gly Gln Val His Lys Arg Cys Ala Thr Ser Leu Asn Ala Ala 
865                 870                 875                 880 


Arg Met Val Leu Ala Gly Tyr Asp His Pro Ile Asn Lys Val Val Gln 
                885                 890                 895     


Asp Leu Val Ser Cys Leu Asp Ala Pro Glu Leu Pro Phe Leu Gln Trp 
            900                 905                 910         


Glu Glu Leu Met Ser Val Leu Ala Thr Arg Leu Pro Arg Leu Leu Lys 
        915                 920                 925             


Ser Glu Leu Glu Gly Lys Tyr Ser Glu Tyr Lys Leu Asn Val Gly His 
    930                 935                 940                 


Gly Lys Ser Lys Asp Phe Pro Ser Lys Met Leu Arg Glu Ile Ile Glu 
945                 950                 955                 960 


Glu Asn Leu Ala His Gly Ser Glu Lys Glu Ile Ala Thr Asn Glu Arg 
                965                 970                 975     


Leu Val Glu Pro Leu Met Ser Leu Leu Lys Ser Tyr Glu Gly Gly Arg 
            980                 985                 990         


Glu Ser His Ala His Phe Ile Val  Lys Ser Leu Phe Glu  Asp Tyr Leu 
        995                 1000                 1005             


Ser Val  Glu Glu Leu Phe Ser  Asp Gly Ile Gln Ser  Asp Val Ile 
    1010                 1015                 1020             


Glu Arg  Leu Arg Gln Gln His  Ser Lys Asp Leu Gln  Lys Val Val 
    1025                 1030                 1035             


Asp Ile  Val Leu Ser His Gln  Gly Val Arg Asn Lys  Thr Lys Leu 
    1040                 1045                 1050             


Ile Leu  Thr Leu Met Glu Lys  Leu Val Tyr Pro Asn  Pro Ala Ala 
    1055                 1060                 1065             


Tyr Lys  Asp Gln Leu Thr Arg  Phe Ser Ser Leu Asn  His Lys Arg 
    1070                 1075                 1080             


Tyr Tyr  Lys Leu Ala Leu Lys  Ala Ser Glu Leu Leu  Glu Gln Thr 
    1085                 1090                 1095             


Lys Leu  Ser Glu Leu Arg Thr  Ser Ile Ala Arg Ser  Leu Ser Glu 
    1100                 1105                 1110             


Leu Glu  Met Phe Thr Glu Glu  Arg Thr Ala Ile Ser  Glu Ile Met 
    1115                 1120                 1125             


Gly Asp  Leu Val Thr Ala Pro  Leu Pro Val Glu Asp  Ala Leu Val 
    1130                 1135                 1140             


Ser Leu  Phe Asp Cys Ser Asp  Gln Thr Leu Gln Gln  Arg Val Ile 
    1145                 1150                 1155             


Glu Thr  Tyr Ile Ser Arg Leu  Tyr Gln Pro His Leu  Val Lys Asp 
    1160                 1165                 1170             


Ser Ile  Gln Leu Lys Tyr Gln  Glu Ser Gly Val Ile  Ala Leu Trp 
    1175                 1180                 1185             


Glu Phe  Ala Glu Ala His Ser  Glu Lys Arg Leu Gly  Ala Met Val 
    1190                 1195                 1200             


Ile Val  Lys Ser Leu Glu Ser  Val Ser Ala Ala Ile  Gly Ala Ala 
    1205                 1210                 1215             


Leu Lys  Asp Thr Ser Arg Tyr  Ala Ser Ser Glu Gly  Asn Ile Met 
    1220                 1225                 1230             


His Ile  Ala Leu Leu Gly Ala  Asp Asn Gln Met His  Gly Thr Glu 
    1235                 1240                 1245             


Asp Ser  Gly Asp Asn Asp Gln  Ala Gln Val Arg Ile  Asp Lys Leu 
    1250                 1255                 1260             


Ser Ala  Thr Leu Glu Gln Asn  Thr Val Thr Ala Asp  Leu Arg Ala 
    1265                 1270                 1275             


Ala Gly  Val Lys Val Ile Ser  Cys Ile Val Gln Arg  Asp Gly Ala 
    1280                 1285                 1290             


Leu Met  Pro Met Arg His Thr  Phe Leu Leu Ser Asp  Glu Lys Leu 
    1295                 1300                 1305             


Cys Tyr  Glu Glu Glu Pro Val  Leu Arg His Val Glu  Pro Pro Leu 
    1310                 1315                 1320             


Ser Ala  Leu Leu Glu Leu Gly  Lys Leu Lys Val Lys  Gly Tyr Asn 
    1325                 1330                 1335             


Glu Val  Lys Tyr Thr Pro Ser  Arg Asp Arg Gln Trp  Asn Ile Tyr 
    1340                 1345                 1350             


Thr Leu  Arg Asn Thr Glu Asn  Pro Lys Met Leu His  Arg Val Phe 
    1355                 1360                 1365             


Phe Arg  Thr Leu Val Arg Gln  Pro Gly Ala Ser Asn  Lys Phe Thr 
    1370                 1375                 1380             


Ser Gly  His Ile Ser Asp Val  Glu Val Gly Gly Ala  Glu Glu Ser 
    1385                 1390                 1395             


Leu Ser  Phe Thr Ser Ser Ser  Ile Leu Arg Ser Leu  Met Thr Ala 
    1400                 1405                 1410             


Ile Glu  Glu Leu Glu Leu His  Ala Ile Arg Thr Gly  His Ser His 
    1415                 1420                 1425             


Met Phe  Leu Cys Ile Leu Lys  Glu Gln Lys Leu Leu  Asp Leu Val 
    1430                 1435                 1440             


Pro Val  Ser Gly Asn Thr Val  Val Asp Ile Gly Gln  Asp Glu Ala 
    1445                 1450                 1455             


Thr Ala  Cys Ser Leu Leu Lys  Glu Met Ala Leu Gln  Ile His Glu 
    1460                 1465                 1470             


Leu Val  Gly Ala Arg Met His  His Leu Ser Val Cys  Gln Trp Glu 
    1475                 1480                 1485             


Val Lys  Leu Lys Leu Asp Ser  Asp Gly Pro Ala Ser  Gly Thr Trp 
    1490                 1495                 1500             


Arg Val  Val Thr Thr Asn Val  Thr Ser His Thr Cys  Thr Val Asp 
    1505                 1510                 1515             


Ile Tyr  Arg Glu Val Glu Asp  Thr Glu Ser Gln Lys  Leu Val Tyr 
    1520                 1525                 1530             


His Ser  Ala Pro Ser Ser Ser  Gly Pro Leu His Gly  Val Ala Leu 
    1535                 1540                 1545             


Asn Thr  Pro Tyr Gln Pro Leu  Ser Val Ile Asp Leu  Lys Arg Cys 
    1550                 1555                 1560             


Ser Ala  Arg Asn Asn Arg Thr  Thr Tyr Cys Tyr Asp  Phe Pro Leu 
    1565                 1570                 1575             


Ala Phe  Glu Thr Ala Val Gln  Lys Ser Trp Ser Asn  Ile Ser Ser 
    1580                 1585                 1590             


Asp Asn  Asn Arg Cys Tyr Val  Lys Ala Thr Glu Leu  Val Phe Ala 
    1595                 1600                 1605             


His Lys  Asn Gly Ser Trp Gly  Thr Pro Val Ile Pro  Met Glu Arg 
    1610                 1615                 1620             


Pro Ala  Gly Leu Asn Asp Ile  Gly Met Val Ala Trp  Ile Leu Asp 
    1625                 1630                 1635             


Met Ser  Thr Pro Glu Tyr Pro  Asn Gly Arg Gln Ile  Val Val Ile 
    1640                 1645                 1650             


Ala Asn  Asp Ile Thr Phe Arg  Ala Gly Ser Phe Gly  Pro Arg Glu 
    1655                 1660                 1665             


Asp Ala  Phe Phe Glu Thr Val  Thr Asn Leu Ala Cys  Glu Arg Lys 
    1670                 1675                 1680             


Leu Pro  Leu Ile Tyr Leu Ala  Ala Asn Ser Gly Ala  Arg Ile Gly 
    1685                 1690                 1695             


Ile Ala  Asp Glu Val Lys Ser  Cys Phe Arg Val Gly  Trp Ser Asp 
    1700                 1705                 1710             


Asp Gly  Ser Pro Glu Arg Gly  Phe Gln Tyr Ile Tyr  Leu Thr Glu 
    1715                 1720                 1725             


Glu Asp  His Ala Arg Ile Ser  Thr Ser Val Ile Ala  His Lys Met 
    1730                 1735                 1740             


Gln Leu  Asp Asn Gly Glu Ile  Arg Trp Val Ile Asp  Ser Val Val 
    1745                 1750                 1755             


Gly Lys  Glu Asp Gly Leu Gly  Val Glu Asn Ile His  Gly Ser Ala 
    1760                 1765                 1770             


Ala Ile  Ala Ser Ala Tyr Ser  Arg Ala Tyr Glu Glu  Thr Phe Thr 
    1775                 1780                 1785             


Leu Thr  Phe Val Thr Gly Arg  Thr Val Gly Ile Gly  Ala Tyr Leu 
    1790                 1795                 1800             


Ala Arg  Leu Gly Ile Arg Cys  Ile Gln Arg Thr Asp  Gln Pro Ile 
    1805                 1810                 1815             


Ile Leu  Thr Gly Phe Ser Ala  Leu Asn Lys Leu Leu  Gly Arg Glu 
    1820                 1825                 1830             


Val Tyr  Ser Ser His Met Gln  Leu Gly Gly Pro Lys  Ile Met Ala 
    1835                 1840                 1845             


Thr Asn  Gly Val Val His Leu  Thr Val Ser Asp Asp  Leu Glu Gly 
    1850                 1855                 1860             


Val Ser  Asn Ile Leu Arg Trp  Leu Ser Tyr Val Pro  Ala Asn Ile 
    1865                 1870                 1875             


Gly Gly  Pro Leu Pro Ile Thr  Lys Ser Leu Asp Pro  Pro Asp Arg 
    1880                 1885                 1890             


Pro Val  Ala Tyr Ile Pro Glu  Asn Thr Cys Asp Pro  Arg Ala Ala 
    1895                 1900                 1905             


Ile Ser  Gly Ile Asp Asp Ser  Gln Gly Lys Trp Leu  Gly Gly Met 
    1910                 1915                 1920             


Phe Asp  Lys Asp Ser Phe Val  Glu Thr Phe Glu Gly  Trp Ala Lys 
    1925                 1930                 1935             


Ser Val  Val Thr Gly Arg Ala  Lys Leu Gly Gly Ile  Pro Val Gly 
    1940                 1945                 1950             


Val Ile  Ala Val Glu Thr Gln  Thr Met Met Gln Leu  Ile Pro Ala 
    1955                 1960                 1965             


Asp Pro  Gly Gln Leu Asp Ser  His Glu Arg Ser Val  Pro Arg Ala 
    1970                 1975                 1980             


Gly Gln  Val Trp Phe Pro Asp  Ser Ala Thr Lys Thr  Ala Gln Ala 
    1985                 1990                 1995             


Met Leu  Asp Phe Asn Arg Glu  Gly Leu Pro Leu Phe  Ile Leu Ala 
    2000                 2005                 2010             


Asn Trp  Arg Gly Phe Ser Gly  Gly Gln Arg Asp Leu  Phe Glu Gly 
    2015                 2020                 2025             


Ile Leu  Gln Ala Gly Ser Thr  Ile Val Glu Asn Leu  Arg Thr Tyr 
    2030                 2035                 2040             


Asn Gln  Pro Ala Phe Val Tyr  Ile Pro Lys Ala Ala  Glu Leu Arg 
    2045                 2050                 2055             


Gly Gly  Ala Trp Val Val Ile  Asp Ser Lys Ile Asn  Pro Asp Arg 
    2060                 2065                 2070             


Ile Glu  Phe Tyr Ala Glu Arg  Thr Ala Lys Gly Asn  Val Leu Glu 
    2075                 2080                 2085             


Pro Gln  Gly Leu Ile Glu Ile  Lys Phe Arg Ser Glu  Glu Leu Gln 
    2090                 2095                 2100             


Glu Cys  Met Gly Arg Leu Asp  Pro Glu Leu Ile Asn  Leu Lys Ala 
    2105                 2110                 2115             


Lys Leu  Gln Gly Val Lys His  Glu Asn Gly Ser Leu  Pro Glu Ser 
    2120                 2125                 2130             


Glu Ser  Leu Gln Lys Ser Ile  Glu Ala Arg Lys Lys  Gln Leu Leu 
    2135                 2140                 2145             


Pro Leu  Tyr Thr Gln Ile Ala  Val Arg Phe Ala Glu  Leu His Asp 
    2150                 2155                 2160             


Thr Ser  Leu Arg Met Ala Ala  Lys Gly Val Ile Lys  Lys Val Val 
    2165                 2170                 2175             


Asp Trp  Glu Asp Ser Arg Ser  Phe Phe Tyr Lys Arg  Leu Arg Arg 
    2180                 2185                 2190             


Arg Ile  Ser Glu Asp Val Leu  Ala Lys Glu Ile Arg  Gly Val Ser 
    2195                 2200                 2205             


Gly Lys  Gln Phe Ser His Gln  Ser Ala Ile Glu Leu  Ile Gln Lys 
    2210                 2215                 2220             


Trp Tyr  Leu Ala Ser Lys Gly  Ala Glu Thr Gly Ser  Thr Glu Trp 
    2225                 2230                 2235             


Asp Asp  Asp Asp Ala Phe Val  Ala Trp Arg Glu Asn  Pro Glu Asn 
    2240                 2245                 2250             


Tyr Gln  Glu Tyr Ile Lys Glu  Leu Arg Ala Gln Arg  Val Ser Gln 
    2255                 2260                 2265             


Leu Leu  Ser Asp Val Ala Asp  Ser Ser Pro Asp Leu  Glu Ala Leu 
    2270                 2275                 2280             


Pro Gln  Gly Leu Ser Met Leu  Leu Glu Lys Met Asp  Pro Ser Arg 
    2285                 2290                 2295             


Arg Ala  Gln Phe Val Glu Glu  Val Lys Lys Val Leu  Lys 
    2300                 2305                 2310     


<210>  16
<211>  644
<212>  PRT
<213>  Oryza sativa

<400>  16

Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Thr Leu Ser Ala Ala Ala 
1               5                   10                  15      


Thr Ala Lys Thr Gly Arg Lys Asn His Gln Arg His His Val Leu Pro 
            20                  25                  30          


Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser 
        35                  40                  45              


Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro 
    50                  55                  60                  


Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala 
65                  70                  75                  80  


Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala 
                85                  90                  95      


Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn 
            100                 105                 110         


His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr 
        115                 120                 125             


Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro 
    130                 135                 140                 


Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser 
145                 150                 155                 160 


Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly 
                165                 170                 175     


Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile 
            180                 185                 190         


Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val 
        195                 200                 205             


Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val 
    210                 215                 220                 


Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val Pro Val 
225                 230                 235                 240 


Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys 
                245                 250                 255     


Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu 
            260                 265                 270         


Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly 
        275                 280                 285             


Asp Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr 
    290                 295                 300                 


Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp 
                325                 330                 335     


Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val 
            340                 345                 350         


Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile 
        355                 360                 365             


Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser 
    370                 375                 380                 


Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu 
385                 390                 395                 400 


Asp Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn 
                405                 410                 415     


Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe 
            420                 425                 430         


Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu 
        435                 440                 445             


Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met 
    450                 455                 460                 


Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser 
465                 470                 475                 480 


Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly 
                485                 490                 495     


Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp 
            500                 505                 510         


Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu 
        515                 520                 525             


Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met 
    530                 535                 540                 


Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr 
545                 550                 555                 560 


Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val 
                565                 570                 575     


Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys 
            580                 585                 590         


Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Glu Thr Pro Gly Pro 
        595                 600                 605             


Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met 
    610                 615                 620                 


Ile Pro Ser Glu Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly 
625                 630                 635                 640 


Arg Thr Met Tyr 
                


<210>  17
<211>  598
<212>  PRT
<213>  Triticum aestivum

<400>  17

Ala Ala Ser Pro Ala Ala Thr Ser Ala Ala Pro Pro Ala Thr Ala Leu 
1               5                   10                  15      


Arg Pro Trp Gly Pro Ser Glu Pro Arg Lys Gly Ala Asp Ile Leu Val 
            20                  25                  30          


Glu Ala Leu Glu Arg Cys Gly Ile Val Asp Val Phe Ala Tyr Pro Gly 
        35                  40                  45              


Gly Ala Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile 
    50                  55                  60                  


Thr Asn His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser 
65                  70                  75                  80  


Gly Tyr Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser 
                85                  90                  95      


Gly Pro Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu 
            100                 105                 110         


Asp Ser Ile Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met 
        115                 120                 125             


Ile Gly Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg 
    130                 135                 140                 


Ser Ile Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro 
145                 150                 155                 160 


Arg Val Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly 
                165                 170                 175     


Pro Val Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val 
            180                 185                 190         


Pro Val Trp Asp Thr Pro Met Ser Leu Pro Gly Tyr Ile Ala Arg Leu 
        195                 200                 205             


Pro Lys Pro Pro Ser Thr Glu Ser Leu Glu Gln Val Leu Arg Leu Val 
    210                 215                 220                 


Gly Glu Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Glu Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile Pro Val 
                245                 250                 255     


Thr Thr Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu 
            260                 265                 270         


Ser Leu Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala 
        275                 280                 285             


Val Asp Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp 
    290                 295                 300                 


Arg Val Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ser Lys Ile Val 
305                 310                 315                 320 


His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His 
                325                 330                 335     


Val Ser Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Asp 
            340                 345                 350         


Leu Leu Asn Gly Ser Lys Ala Gln Gln Gly Leu Asp Phe Gly Pro Trp 
        355                 360                 365             


His Lys Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Phe Lys 
    370                 375                 380                 


Thr Phe Gly Glu Ala Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His 
                405                 410                 415     


Gln Met Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp 
            420                 425                 430         


Leu Ser Ser Ser Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala 
        435                 440                 445             


Ala Gly Ala Ala Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp 
    450                 455                 460                 


Gly Asp Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg 
465                 470                 475                 480 


Ile Glu Asn Leu Pro Val Lys Val Met Ile Leu Asn Asn Gln His Leu 
                485                 490                 495     


Gly Met Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala 
            500                 505                 510         


His Thr Tyr Leu Gly Asn Pro Glu Asn Glu Ser Glu Ile Tyr Pro Asp 
        515                 520                 525             


Phe Val Thr Ile Ala Lys Gly Phe Asn Val Pro Ala Val Arg Val Thr 
    530                 535                 540                 


Lys Lys Ser Glu Val Thr Ala Ala Ile Lys Lys Met Leu Glu Thr Pro 
545                 550                 555                 560 


Gly Pro Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu 
                565                 570                 575     


Pro Met Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Met Glu Gly 
            580                 585                 590         


Asp Gly Arg Thr Ser Tyr 
        595             


<210>  18
<211>  436
<212>  PRT
<213>  Triticum aestivum

<400>  18

Met Pro Pro Thr Pro Thr Thr Pro Ala Ala Thr Gly Ala Gly Ala Ala 
1               5                   10                  15      


Ala Ala Val Thr Pro Glu His Ala Arg Pro Arg Arg Met Val Arg Phe 
            20                  25                  30          


Asn Pro Arg Ser Asp Arg Phe His Thr Leu Ser Phe His His Val Glu 
        35                  40                  45              


Phe Trp Cys Ala Asp Ala Ala Ser Ala Ala Gly Arg Phe Ala Phe Ala 
    50                  55                  60                  


Leu Gly Ala Pro Leu Ala Ala Arg Ser Asp Leu Ser Thr Gly Asn Ser 
65                  70                  75                  80  


Val His Ala Ser Gln Leu Leu Arg Ser Gly Asn Leu Ala Phe Leu Phe 
                85                  90                  95      


Thr Ala Pro Tyr Ala Asn Gly Cys Asp Ala Ala Thr Ala Ser Leu Pro 
            100                 105                 110         


Ser Phe Ser Ala Asp Ala Ala Arg Arg Phe Ser Ala Asp His Gly Leu 
        115                 120                 125             


Ala Val Arg Ser Ile Ala Leu Arg Val Ala Asp Ala Ala Glu Ala Phe 
    130                 135                 140                 


Arg Ala Ser Val Asp Gly Gly Ala Arg Pro Ala Phe Ser Pro Val Asp 
145                 150                 155                 160 


Leu Gly Arg Gly Phe Gly Phe Ala Glu Val Glu Leu Tyr Gly Asp Val 
                165                 170                 175     


Val Leu Arg Phe Val Ser His Pro Asp Asp Thr Asp Val Pro Phe Leu 
            180                 185                 190         


Pro Gly Phe Glu Gly Val Ser Asn Pro Asp Ala Val Asp Tyr Gly Leu 
        195                 200                 205             


Thr Arg Phe Asp His Val Val Gly Asn Val Pro Glu Leu Ala Pro Ala 
    210                 215                 220                 


Ala Ala Tyr Val Ala Gly Phe Ala Gly Phe His Glu Phe Ala Glu Phe 
225                 230                 235                 240 


Thr Thr Glu Asp Val Gly Thr Ala Glu Ser Gly Leu Asn Ser Met Val 
                245                 250                 255     


Leu Ala Asn Asn Ser Glu Gly Val Leu Leu Pro Leu Asn Glu Pro Val 
            260                 265                 270         


His Gly Thr Lys Arg Arg Ser Gln Ile Gln Thr Phe Leu Glu His His 
        275                 280                 285             


Gly Gly Ser Gly Val Gln His Ile Ala Val Ala Ser Ser Asp Val Leu 
    290                 295                 300                 


Arg Thr Leu Arg Glu Met Arg Ala Arg Ser Ala Met Gly Gly Phe Asp 
305                 310                 315                 320 


Phe Leu Pro Pro Arg Cys Arg Lys Tyr Tyr Glu Gly Val Arg Arg Ile 
                325                 330                 335     


Ala Gly Asp Val Leu Ser Glu Ala Gln Ile Lys Glu Cys Gln Glu Leu 
            340                 345                 350         


Gly Val Leu Val Asp Arg Asp Asp Gln Gly Val Leu Leu Gln Ile Phe 
        355                 360                 365             


Thr Lys Pro Val Gly Asp Arg Pro Thr Leu Phe Leu Glu Met Ile Gln 
    370                 375                 380                 


Arg Ile Gly Cys Met Glu Lys Asp Glu Arg Gly Glu Glu Tyr Gln Lys 
385                 390                 395                 400 


Gly Gly Cys Gly Gly Phe Gly Lys Gly Asn Phe Ser Glu Leu Phe Lys 
                405                 410                 415     


Ser Ile Glu Asp Tyr Glu Lys Ser Leu Glu Ala Lys Gln Ser Ala Ala 
            420                 425                 430         


Val Gln Gly Ser 
        435     


<210>  19
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R1

<400>  19
cctacccggg cggcgcgtcc atg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R2

<400>  20
caggtccccc gccgcatgat cgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R3

<400>  21
ccgcatgatc ggcaccgacg cct                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R4

<400>  22
cctatgatcc caagtggggg cgc                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R5

<400>  23
tattgattct gttgtgggca agg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R6

<400>  24
ccagtgctta ttctagggca tat                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R7

<400>  25
ccggtgcata cagcgtcttg acc                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R8

<400>  26
atcttgctcg acttggcatc cgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R9

<400>  27
tctgcactga acaagcttct tgg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R10

<400>  28
ccacatgcag ttgggtggtc cca                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R11

<400>  29
ccatcttact gtttcagatg acc                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R12

<400>  30
ccctgctgac cctggtcagc ttg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R13

<400>  31
ttcctcgtgc tggacaagtg tgg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R14

<400>  32
ttctgcaacc aagactgcgc agg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R15

<400>  33
caagactgcg caggcattgc tgg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R16

<400>  34
cctcgctaac tggagaggct tct                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R17

<400>  35
cgactattgt tgagaacctt agg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R18

<400>  36
ccatggctgc agagctacga gga                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R19

<400>  37
ccgcattgag tgctatgctg aga                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R20

<400>  38
tatgctgaga ggactgcaaa agg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R21

<400>  39
ccgcaagggt taattgagat caa                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R22

<400>  40
gcaatgttct ggaaccgcaa ggg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R23

<400>  41
ccaggattgc atgagtcggc ttg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R24

<400>  42
ggagcttatc ttgctcgact tgg                                               23


<210>  43
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R25

<400>  43
caggtccccc gccgcatgat cggcctaccc gggcggcgcg tccatg                      46


<210>  44
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R26

<400>  44
caggtccccc gccgcatgat cggccgcatg atcggcaccg acgcct                      46


<210>  45
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R27

<400>  45
caggtccccc gccgcatgat cggcctatga tcccaagtgg gggcgc                      46


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R28

<400>  46
gctgctgccg ctcaacgagc cgg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R29

<400>  47
ccaggagctc ggggtgctcg tgg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R30

<400>  48
ccagaagggc ggctgcggcg ggt                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W1

<400>  49
caggtccccc gccgcatgat cgg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W2

<400>  50
ccgcatgatc ggcacggacg cgt                                               23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W3

<400>  51
cctatgatcc caagcggtgg tgc                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W4

<400>  52
ccagtgccta ttctagggcc tat                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W5

<400>  53
cctattctag ggcctatgag gag                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W6

<400>  54
tttacgctta catttgtgac tgg                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W7

<400>  55
ggagcatatc ttgctcgact tgg                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W8

<400>  56
cccacatgca gttgggtggc ccc                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W9

<400>  57
agctcccaca tgcagttggg tgg                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W10

<400>  58
ccatctgaca gtttcagatg acc                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W11

<400>  59
ccttgctaac tggagaggct tct                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W12

<400>  60
ttcatccttg ctaactggag agg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W13

<400>  61
caacaattgt tgagaacctt agg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W14

<400>  62
agagctacgt ggaggggctt ggg                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W15

<400>  63
tatgctgaga ggactgcaaa ggg                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W16

<400>  64
cctaccctgg cggcgcgtcc atg                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W17

<400>  65
ccctgctgat ccaggccagc ttg                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W18

<400>  66
ccagcttgat tcccatgagc ggt                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W19

<400>  67
ttcctcgtgc tgggcaagtc tgg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W20

<400>  68
taagacagcg caggcaatgc tgg                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W21

<400>  69
ttcagctact aagacagcgc agg                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W22

<400>  70
gtaatgttct tgaacctcaa ggg                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W23

<400>  71
cctcaagggt tgattgagat caa                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W24

<400>  72
ccaagagtgc atgggcaggc ttg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W25

<400>  73
aactgcaatg cggccactga cgg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W26

<400>  74
aactgcaatg cgtccattga cgg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W27

<400>  75
aactgcaatg cggccattga cgg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W28

<400>  76
gctgctgccg ctcaacgagc cgg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W29

<400>  77
ccaggagctg ggggtgctcg tcg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  W30

<400>  78
ccagaagggt ggctgcggcg ggt                                               23


