                         б

<110>  ϺƼ޹˾
 
<120>  ˫鵰׼Ӧ

<130>  IEC170144PCT

<150>  CN201710317926.7
<151>  2017-05-08

<150>  CN201711269620.5
<151>  2017-12-05

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ofa

<400>  1

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  2
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ofa

<400>  2

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  3
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Obi

<400>  3

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  4
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Obi/Obi-Fc1

<400>  4

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  5
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu5F9-G4

<400>  5

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
        35                  40                  45              


Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp 
    50                  55                  60                  


Met Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys 
65                  70                  75                  80  


Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala 
                85                  90                  95      


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460     


<210>  6
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu5F9-G4

<400>  6

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
            20                  25                  30          


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr 
        35                  40                  45              


Ser Asn Gly Asn Thr Tyr Leu Gly Trp Tyr Leu Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
                85                  90                  95      


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln 
            100                 105                 110         


Gly Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  7
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JMT101

<400>  7

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
            20                  25                  30          


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn 
        35                  40                  45              


Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
65                  70                  75                  80  


Thr Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
                85                  90                  95      


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Ala Leu Asp Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  8
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JMT101/Anti-EGFR-Fc1

<400>  8

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro 
            20                  25                  30          


Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr 
        35                  40                  45              


Asn Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu 
    50                  55                  60                  


Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu 
                85                  90                  95      


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Trp Pro 
            100                 105                 110         


Thr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    130                 135                 140                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
145                 150                 155                 160 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                165                 170                 175     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            180                 185                 190         


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        195                 200                 205             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    210                 215                 220                 


Ser Phe Asn Arg Gly Glu Cys 
225                 230     


<210>  9
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab

<400>  9

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
        35                  40                  45              


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  10
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab

<400>  10

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            20                  25                  30          


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr 
        35                  40                  45              


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
    50                  55                  60                  


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                85                  90                  95      


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
            100                 105                 110         


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    130                 135                 140                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
145                 150                 155                 160 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                165                 170                 175     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            180                 185                 190         


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        195                 200                 205             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    210                 215                 220                 


Ser Phe Asn Arg Gly Glu Cys 
225                 230     


<210>  11
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SIRP D1-Fc

<400>  11

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser 
        35                  40                  45              


Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala 
    50                  55                  60                  


Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser 
                85                  90                  95      


Ile Ser Ala Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr 
        115                 120                 125             


Glu Leu Ser Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  12
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab

<400>  12

Met Glu Phe Trp Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  13
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab/Anti-PD-L1(Ate)-Fc1

<400>  13

Met Glu Phe Trp Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr 
            100                 105                 110         


His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  14
<211>  1092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1-Fc2 DNA

<400>  14
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgaa       60

gaggagctgc aggtcatcca gcccgataag agcgtgtccg tggccgcagg agaatctgcc      120

atcctgcatt gcaccgtgac ctctctgatc cccgtgggcc caatccagtg gttcagagga      180

gccggaccag ctagagagct gatctacaac cagaaggagg gccacttccc cagagtgaca      240

accgtgtccg agtctaccaa gcgggagaac atggacttct ccatctccat ctccgccatc      300

acaccagccg acgccggcac ctactattgc gtgaagttcc ggaagggctc cccagatacc      360

gagtttaaga gcggcgccgg aacagagctg agcgtgcggg ctaagcctga caagacccac      420

acctgtcccc cttgtcctgc ccctgaactg ctgggcggac cttccgtgtt cctgttcccc      480

ccaaagccca aggacaccct gatgatctcc cggacccccg aagtgacctg cgtggtggtg      540

gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg      600

cacaacgcca agaccaagcc tagagaggaa cagtacaact ccacctaccg ggtggtgtcc      660

gtgctgaccg tgctgcacca ggattggctg aacggcaaag agtacaagtg caaggtgtcc      720

aacaaggccc tgcctgcccc catcgaaaag accatctcca aggccaaggg ccagccccgg      780

gaaccccagg tgtacacact gccccctagc agggacgagc tgaccaagaa ccaggtgtcc      840

ctgtggtgtc tcgtgaaagg cttctacccc tccgacattg ccgtggaatg ggagtccaac      900

ggccagcctg agaacaacta caagaccacc ccccctgtgc tggactccga cggctcattc      960

ttcctgtaca gcaagctgac agtggacaag tcccggtggc agcagggcaa cgtgttctcc     1020

tgctccgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gtccctgagc     1080

cccggcaaat ga                                                         1092


<210>  15
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1-D2-Fc2 DNA

<400>  15
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgaa       60

gaggagctgc aggtcatcca gcccgataag agcgtgtccg tggccgcagg agaatctgcc      120

atcctgcatt gcaccgtgac ctctctgatc cccgtgggcc caatccagtg gttcagagga      180

gccggaccag ctagagagct gatctacaac cagaaggagg gccacttccc cagagtgaca      240

accgtgtccg agtctaccaa gcgggagaac atggacttct ccatctccat ctccgccatc      300

acaccagccg acgccggcac ctactattgc gtgaagttcc ggaagggctc cccagatacc      360

gagtttaaga gcggcgccgg aacagagctg agcgtgcggg ctaagccttc tgctccagtg      420

gtgtcaggac cagcagctag agctacccct cagcacaccg tgtccttcac ctgcgagtct      480

cacggcttct cccctagaga catcaccctc aagtggttca agaacggcaa cgagctgtcc      540

gacttccaga ccaacgtgga tccagtgggc gagagcgtgt cttactccat ccactccacc      600

gccaaggtgg tgctgacaag ggaggacgtg cactcccagg tcatttgcga ggtggcacac      660

gtgacattgc agggcgaccc cctgagggga accgccaact tgagtgacaa gacccacacc      720

tgtccccctt gtcctgcccc tgaactgctg ggcggacctt ccgtgttcct gttcccccca      780

aagcccaagg acaccctgat gatctcccgg acccccgaag tgacctgcgt ggtggtggat      840

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaagtgcac      900

aacgccaaga ccaagcctag agaggaacag tacaactcca cctaccgggt ggtgtccgtg      960

ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa ggtgtccaac     1020

aaggccctgc ctgcccccat cgaaaagacc atctccaagg ccaagggcca gccccgggaa     1080

ccccaggtgt acacactgcc ccctagcagg gacgagctga ccaagaacca ggtgtccctg     1140

tggtgtctcg tgaaaggctt ctacccctcc gacattgccg tggaatggga gtccaacggc     1200

cagcctgaga acaactacaa gaccaccccc cctgtgctgg actccgacgg ctcattcttc     1260

ctgtacagca agctgacagt ggacaagtcc cggtggcagc agggcaacgt gttctcctgc     1320

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgagcccc     1380

ggcaaatga                                                             1389


<210>  16
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ofa-Fc1

<400>  16

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  17
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ofa-Fc1 

<400>  17

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  18
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Obi-Fc1

<400>  18

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Asn Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
65                  70                  75                  80  


Pro Phe Thr Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Ala Leu Asp Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  19
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR-Fc1

<400>  19

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Asn Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
65                  70                  75                  80  


Pro Phe Thr Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Ala Leu Asp Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  20
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(T)-Fc1

<400>  20

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  21
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(T)-Fc1

<400>  21

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  22
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(P)-Fc1

<400>  22

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  23
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(P)-Fc1 

<400>  23

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  24
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1(Ate)-Fc1

<400>  24

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  25
<211>  1641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1-D2-D3-Fc2 DNA

<400>  25
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgaa       60

gaggagctgc aggtcatcca gcccgataag agcgtgtccg tggccgcagg agaatctgcc      120

atcctgcatt gcaccgtgac ctctctgatc cccgtgggcc caatccagtg gttcagagga      180

gccggaccag ctagagagct gatctacaac cagaaggagg gccacttccc cagagtgaca      240

accgtgtccg agtctaccaa gcgggagaac atggacttct ccatctccat ctccgccatc      300

acaccagccg acgccggcac ctactattgc gtgaagttcc ggaagggctc cccagatacc      360

gagtttaaga gcggcgccgg aacagagctg agcgtgcggg ctaagccttc tgctccagtg      420

gtgtcaggac cagcagctag agctacccct cagcacaccg tgtccttcac ctgcgagtct      480

cacggcttct cccctagaga catcaccctc aagtggttca agaacggcaa cgagctgtcc      540

gacttccaga ccaacgtgga tccagtgggc gagagcgtgt cttactccat ccactccacc      600

gccaaggtgg tgctgacaag ggaggacgtg cactcccagg tcatttgcga ggtggcacac      660

gtgacattgc agggcgaccc cctgagaggc acagcaaact tgagcgagac aattagagtg      720

ccccccaccc tggaagttac acagcagccc gttagagccg agaaccaggt caacgtcacc      780

tgccaggtca gaaagtttta tccacagaga ctgcagctga cctggctcga gaacggaaac      840

gtgagcagaa cagagaccgc cagcaccgtg acagagaaca aggacgggac ctacaactgg      900

atgagttggc tgctggtgaa cgtcagcgcc cacagagacg acgtcaagct gacctgcgac      960

aagacccaca cctgtccccc ttgtcctgcc cctgaactgc tgggcggacc ttccgtgttc     1020

ctgttccccc caaagcccaa ggacaccctg atgatctccc ggacccccga agtgacctgc     1080

gtggtggtgg atgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc     1140

gtggaagtgc acaacgccaa gaccaagcct agagaggaac agtacaactc cacctaccgg     1200

gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaaaga gtacaagtgc     1260

aaggtgtcca acaaggccct gcctgccccc atcgaaaaga ccatctccaa ggccaagggc     1320

cagccccggg aaccccaggt gtacacactg ccccctagca gggacgagct gaccaagaac     1380

caggtgtccc tgtggtgtct cgtgaaaggc ttctacccct ccgacattgc cgtggaatgg     1440

gagtccaacg gccagcctga gaacaactac aagaccaccc cccctgtgct ggactccgac     1500

ggctcattct tcctgtacag caagctgaca gtggacaagt cccggtggca gcagggcaac     1560

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1620

tccctgagcc ccggcaaatg a                                               1641


<210>  26
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1-Fc2 

<400>  26

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser 
        35                  40                  45              


Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala 
    50                  55                  60                  


Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser 
                85                  90                  95      


Ile Ser Ala Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr 
        115                 120                 125             


Glu Leu Ser Val Arg Ala Lys Pro Asp Lys Thr His Thr Cys Pro Pro 
    130                 135                 140                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            180                 185                 190         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            260                 265                 270         


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360             


<210>  27
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1-D2-Fc2 

<400>  27

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser 
        35                  40                  45              


Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala 
    50                  55                  60                  


Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser 
                85                  90                  95      


Ile Ser Ala Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr 
        115                 120                 125             


Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro 
    130                 135                 140                 


Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser 
145                 150                 155                 160 


His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly 
                165                 170                 175     


Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser 
            180                 185                 190         


Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu 
        195                 200                 205             


Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln 
    210                 215                 220                 


Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  28
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1-D2-D3-Fc2 

<400>  28

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser 
        35                  40                  45              


Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala 
    50                  55                  60                  


Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser 
                85                  90                  95      


Ile Ser Ala Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr 
        115                 120                 125             


Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro 
    130                 135                 140                 


Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser 
145                 150                 155                 160 


His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly 
                165                 170                 175     


Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser 
            180                 185                 190         


Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu 
        195                 200                 205             


Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln 
    210                 215                 220                 


Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val 
225                 230                 235                 240 


Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln 
                245                 250                 255     


Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln 
            260                 265                 270         


Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser 
        275                 280                 285             


Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu 
    290                 295                 300                 


Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Asp 
305                 310                 315                 320 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                325                 330                 335     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            340                 345                 350         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        355                 360                 365             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    370                 375                 380                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
385                 390                 395                 400 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                405                 410                 415     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            420                 425                 430         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        435                 440                 445             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    450                 455                 460                 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
465                 470                 475                 480 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                485                 490                 495     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            500                 505                 510         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        515                 520                 525             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    530                 535                 540                 


Gly Lys 
545     


<210>  29
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1m-Fc2 

<400>  29

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser 
        35                  40                  45              


Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala 
    50                  55                  60                  


Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Glu Thr Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr 
        115                 120                 125             


Glu Leu Ser Val Arg Ala Lys Pro Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Lys 
    


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 

<400>  30

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Ala 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro 
        115         


<210>  31
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1-D2 

<400>  31

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Ala 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg 
        115                 120                 125             


Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe 
    130                 135                 140                 


Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu 
145                 150                 155                 160 


Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr 
                165                 170                 175     


Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His 
            180                 185                 190         


Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro 
        195                 200                 205             


Leu Arg Gly Thr Ala Asn Leu Ser 
    210                 215     


<210>  32
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1-D2-D3 

<400>  32

Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Val Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Ser Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Ala 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg 
        115                 120                 125             


Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe 
    130                 135                 140                 


Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu 
145                 150                 155                 160 


Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr 
                165                 170                 175     


Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His 
            180                 185                 190         


Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro 
        195                 200                 205             


Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr 
    210                 215                 220                 


Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val 
225                 230                 235                 240 


Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp 
                245                 250                 255     


Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr 
            260                 265                 270         


Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn 
        275                 280                 285             


Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys 
    290                 295                 300 


<210>  33
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1m 

<400>  33

Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Glu Thr Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Glu Pro Lys Ser Ser 
        115                 120             


<210>  34
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ofa-Fc1DNA

<400>  34
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgaa       60

gtgcagctgg tggaatctgg cggcggactg gtgcagcctg gcagatccct gagactgtct      120

tgtgccgcct ccggcttcac cttcaacgac tacgccatgc actgggtgcg acaggcccct      180

ggcaaaggcc tggaatgggt gtccaccatc agctggaact ccggctccat cggctacgcc      240

gactccgtga agggccggtt caccatctcc cgggacaacg ccaagaagtc cctgtacctg      300

cagatgaact ccctgcgggc cgaggacacc gccctgtact actgtgccaa ggacatccag      360

tacggcaact actactacgg catggacgtg tggggccagg gcaccacagt gaccgtgtca      420

tctgcttcta ccaagggccc ctccgtgttt cctctggccc cttccagcaa gtccacctct      480

ggcggaacag ccgctctggg ctgcctcgtg aaggactact tccccgagcc tgtgaccgtg      540

tcctggaact ctggcgctct gacatccggc gtgcacacct tccctgctgt gctgcagtct      600

agcggcctgt actccctgtc ctccgtcgtg accgtgcctt ccagctctct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggaa      720

cccaagtcct gcgacaagac ccacacctgt cccccttgtc ctgcccctga actgctgggc      780

ggaccttccg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat ctcccggacc      840

cccgaagtga cctgcgtggt ggtggatgtg tcccacgagg accctgaagt gaagttcaat      900

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac      960

aactccacct accgggtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc     1020

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg cccccatcga aaagaccatc     1080

tccaaggcca agggccagcc ccgggaaccc caggtgtaca cactgccccc tagcagggac     1140

gagctgacca agaaccaggt gtccctgagc tgtgcagtga aaggcttcta cccctccgac     1200

attgccgtgg aatgggagtc caacggccag cctgagaaca actacaagac caccccccct     1260

gtgctggact ccgacggctc attcttcctg gtgagcaagc tgacagtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactac     1380

acccagaagt ccctgtccct gagccccggc aaatga                               1416


<210>  35
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ofa-Fc1DNA

<400>  35
atgtctgtgc ctacccaggt gctgggactg ctgctgctgt ggctgacaga cgcccgctgt       60

gagatcgtgc tgacccagtc tcctgccacc ctgtctctga gccctggcga gagagctacc      120

ctgtcctgca gagcctccca gtccgtgtcc tcttacctgg cctggtatca gcagaagccc      180

ggccaggctc cccggctgct gatctacgat gcctccaata gagccaccgg catccctgcc      240

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctggaaccc      300

gaggacttcg ccgtgtacta ctgccagcag cggtccaact ggcccatcac ctttggccag      360

ggcacccggc tggaaatcaa gagaaccgtg gccgctccct ccgtgttcat cttcccacct      420

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      540

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      600

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      660

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gctga                      705


<210>  36
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Obi-Fc1DNA

<400>  36
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctcag       60

gtgcagctgg tgcagtctgg cgccgaagtg aagaaacccg gctcctccgt gaaggtgtcc      120

tgcaaggctt ccggctacgc cttctcctac tcctggatca actgggtgcg acaggcccct      180

ggacagggcc tggaatggat gggcagaatc ttccctggcg acggcgacac cgactacaac      240

ggcaagttca agggcagagt gaccatcacc gccgacaagt ccacctccac cgcctacatg      300

gaactgtcct ccctgcggag cgaggacacc gccgtgtact actgcgcccg gaacgtgttc      360

gacggctact ggctggtgta ttggggccag ggcaccctcg tgaccgtgtc ctctgcttct      420

accaagggcc cctccgtgtt tcctctggcc ccttccagca agtccacctc tggcggaaca      480

gccgctctgg gctgcctcgt gaaggactac ttccccgagc ctgtgaccgt gtcctggaac      540

tctggcgctc tgacatccgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gaccgtgcct tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta caactccacc      960

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac     1020

aagtgcaagg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgtc ctgtgctgtg aaaggcttct acccctccga cattgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct ggtgagcaag ctgacagtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210>  37
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR-Fc1 DNA

<400>  37
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctcag       60

gtccagctcc aggaaagcgg ccccggcctc gtcaaaccct ccgagacact ctccctcaca      120

tgcacagtct ccggcttctc cctcagcaac tacgacgtcc actgggtcag acaggccccc      180

ggcaaaggac tggaatggct cggcgtcatc tggtccggcg gaaacaccga ctacaacacc      240

ccattcacct ccaggctcac catctccgtg gacacctcca agaaccagtt ctccctcaaa      300

ctgagctccg tgaccgccgc cgacaccgct gtctattatt gcgccagagc cctcgactac      360

tacgactacg aattcgccta ctggggccag ggcaccctgg tgaccgtgtc atctgcttct      420

accaagggcc cctccgtgtt tcctctggcc ccttccagca agtccacctc tggcggaaca      480

gccgctctgg gctgcctcgt gaaggactac ttccccgagc ctgtgaccgt gtcctggaac      540

tctggcgctc tgacatccgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gaccgtgcct tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta caactccacc      960

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac     1020

aagtgcaagg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgag ctgtgcagtg aaaggcttct acccctccga cattgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct ggtgagcaag ctgacagtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210>  38
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(T)-Fc1 DNA

<400>  38
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgag       60

gtgcagttgg tggagagcgg gggggggctg gtgcagcctg gaggaagttt gaggttgagc      120

tgtgccgcaa gcgggttcaa cattaaggac acatacattc actgggtgag gcaggcaccc      180

ggaaagggac tggagtgggt ggctaggatc taccccacca acggctacac aaggtacgcc      240

gacagtgtga agggccggtt caccatttcc gccgacacct ccaagaacac cgcctacctg      300

cagatgaaca gcctgagggc cgaggacacc gccgtctact actgctccag gtggggagga      360

gacggattct atgctatgga ctactgggga cagggcaccc tggtgaccgt gtcatctgct      420

tctaccaagg gcccctccgt gtttcctctg gccccttcca gcaagtccac ctctggcgga      480

acagccgctc tgggctgcct cgtgaaggac tacttccccg agcctgtgac cgtgtcctgg      540

aactctggcg ctctgacatc cggcgtgcac accttccctg ctgtgctgca gtctagcggc      600

ctgtactccc tgtcctccgt cgtgaccgtg ccttccagct ctctgggcac ccagacctac      660

atctgcaacg tgaaccacaa gccctccaac accaaggtgg acaagaaggt ggaacccaag      720

tcctgcgaca agacccacac ctgtccccct tgtcctgccc ctgaactgct gggcggacct      780

tccgtgttcc tgttcccccc aaagcccaag gacaccctga tgatctcccg gacccccgaa      840

gtgacctgcg tggtggtgga tgtgtcccac gaggaccctg aagtgaagtt caattggtac      900

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gtacaactcc      960

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag     1020

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgaaaagac catctccaag     1080

gccaagggcc agccccggga accccaggtg tacacactgc cccctagcag ggacgagctg     1140

accaagaacc aggtgtccct gagctgtgca gtgaaaggct tctacccctc cgacattgcc     1200

gtggaatggg agtccaacgg ccagcctgag aacaactaca agaccacccc ccctgtgctg     1260

gactccgacg gctcattctt cctggtgagc aagctgacag tggacaagtc ccggtggcag     1320

cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     1380

aagtccctgt ccctgagccc cggcaaatga                                      1410


<210>  39
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(T)-Fc1 DNA

<400>  39
atgtctgtgc ctacccaggt gctgggactg ctgctgctgt ggctgacaga cgcccgctgt       60

gacattcaga tgacccagag cccctcctcc ctctccgcct ccgtgggaga cagagttacc      120

atcacctgca gggcctccca ggacgtgaac accgccgtgg cctggtacca gcagaaaccc      180

ggcaaagccc ccaaactgct catctactcc gcctcatttc tgtacagcgg cgtgccctcc      240

cgcttctccg gttccagatc cggcaccgac ttcaccctga ctatctcctc cctccagccc      300

gaagacttcg ccacctacta ctgccagcag cactacacca ccccccccac cttcggccag      360

ggcacaaagg tcgaaatcaa gagaaccgtg gccgctccct ccgtgttcat cttcccacct      420

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      540

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      600

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      660

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gctga                      705


<210>  40
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(P)-Fc1DNA

<400>  40
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgag       60

gtgcagttgg tggagagcgg gggggggctg gtgcagcctg gaggaagttt gaggttgagc      120

tgtgccgcaa gcgggttcac atttacagac tacacaatgg actgggtgag gcaggcaccc      180

ggaaagggac tggagtgggt ggctgatgtg aatcccaata gcggagggag catttacaac      240

cagagattca aggggcggtt caccttgtcc gtggacagga gcaagaacac actgtacctg      300

cagatgaaca gcctgagggc cgaggatacc gccgtctact attgcgccag gaacctcgga      360

ccctccttct attttgacta ctggggccag ggaaccctgg tgaccgtgtc atctgcttct      420

accaagggcc cctccgtgtt tcctctggcc ccttccagca agtccacctc tggcggaaca      480

gccgctctgg gctgcctcgt gaaggactac ttccccgagc ctgtgaccgt gtcctggaac      540

tctggcgctc tgacatccgg cgtgcacacc ttccctgctg tgctgcagtc tagcggcctg      600

tactccctgt cctccgtcgt gaccgtgcct tccagctctc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga acccaagtcc      720

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aactgctggg cggaccttcc      780

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      840

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      900

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta caactccacc      960

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac     1020

aagtgcaagg tgtccaacaa ggccctgcct gcccccatcg aaaagaccat ctccaaggcc     1080

aagggccagc cccgggaacc ccaggtgtac acactgcccc ctagcaggga cgagctgacc     1140

aagaaccagg tgtccctgag ctgtgcagtg aaaggcttct acccctccga cattgccgtg     1200

gaatgggagt ccaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1260

tccgacggct cattcttcct ggtgagcaag ctgacagtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tccctgtccc tgagccccgg caaatga                                         1407


<210>  41
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Her2(P)-Fc1 DNA

<400>  41
atgtctgtgc ctacccaggt gctgggactg ctgctgctgt ggctgacaga cgcccgctgt       60

gacattcaga tgacccagag cccctcctcc ctctccgcct ccgtgggaga cagagttacc      120

atcacctgca aagccagcca ggacgtgagc atcggcgtgg cctggtacca gcagaaaccc      180

ggcaaagccc ccaaactgct catttactcc gcctcatacc gttacaccgg cgttccctcc      240

cgcttcagcg gatccggctc cggaaccgac ttcaccctga ctatctcctc cctccagccc      300

gaagacttcg ccacctacta ctgccagcag tactacattt acccctacac cttcggccag      360

ggcaccaagg tggaaatcaa gagaaccgtg gccgctccct ccgtgttcat cttcccacct      420

tccgacgagc agctgaagtc cggcaccgct tctgtcgtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      540

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      600

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      660

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gctga                      705


<210>  42
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-PD-L1(Ate)-Fc1 DNA

<400>  42
atggaatgga gctgggtgtt cctgttcttt ctgtccgtga ccacaggcgt gcattctgaa       60

gtgcagctgg tggaaagcgg cggcggcctg gtgcagccgg gcggcagcct gcgcctgagc      120

tgcgcggcga gcggctttac ctttagcgat agctggattc attgggtgcg ccaggcgccg      180

ggcaaaggcc tggaatgggt ggcgtggatt agcccgtatg gcggcagcac ctattatgcg      240

gatagcgtga aaggccgctt taccattagc gcggatacca gcaaaaacac cgcgtatctg      300

cagatgaaca gcctgcgcgc ggaagatacc gcggtgtatt attgcgcgcg ccgccattgg      360

ccgggcggct ttgattactg gggccagggc accctggtga ccgtgtcatc tgcttctacc      420

aagggcccct ccgtgtttcc tctggcccct tccagcaagt ccacctctgg cggaacagcc      480

gctctgggct gcctcgtgaa ggactacttc cccgagcctg tgaccgtgtc ctggaactct      540

ggcgctctga catccggcgt gcacaccttc cctgctgtgc tgcagtctag cggcctgtac      600

tccctgtcct ccgtcgtgac cgtgccttcc agctctctgg gcacccagac ctacatctgc      660

aacgtgaacc acaagccctc caacaccaag gtggacaaga aggtggaacc caagtcctgc      720

gacaagaccc acacctgtcc cccttgtcct gcccctgaac tgctgggcgg accttccgtg      780

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      840

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      900

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa ctccacctac      960

cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag     1020

tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaaa agaccatctc caaggccaag     1080

ggccagcccc gggaacccca ggtgtacaca ctgcccccta gcagggacga gctgaccaag     1140

aaccaggtgt ccctgagctg tgcagtgaaa ggcttctacc cctccgacat tgccgtggaa     1200

tgggagtcca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggactcc     1260

gacggctcat tcttcctggt gagcaagctg acagtggaca agtcccggtg gcagcagggc     1320

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1380

ctgtccctga gccccggcaa atga                                            1404


<210>  43
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1m-Fc2 DNA

<400>  43
atggagtgga gctgggtgtt cttgttcttc ttgtccgtga ccaccggggt gcacagcgag       60

gaggagttgc agatcatcca gcctgacaag agcgtgagcg tggccgccgg ggagagcgct      120

attctgcact gtaccatcac ctccctcttc cccgtgggcc ccattcagtg gttcagggga      180

gccgggcccg ccagagttct gatttacaac cagaggcagg gcccctttcc ccgggttacc      240

actgtctctg agaccaccaa gcgggagaac atggatttca gcatctccat cagcaacatt      300

actcccgccg acgccggcac ctactactgc atcaaattca gaaagggctc tcccgacacc      360

gaattcaaaa gcggcgccgg caccgaactg tccgtgcgag ctaagccctc cgagcccaaa      420

tcctcagaca agacccacac ctgtccccct tgtcctgccc ctgaactgct gggcggacct      480

tccgtgttcc tgttcccccc aaagcccaag gacaccctga tgatctcccg gacccccgaa      540

gtgacctgcg tggtggtgga tgtgtcccac gaggaccctg aagtgaagtt caattggtac      600

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gtacaactcc      660

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag      720

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgaaaagac catctccaag      780

gccaagggcc agccccggga accccaggtg tacacactgc cccctagcag ggacgagctg      840

accaagaacc aggtgtccct gtggtgtctc gtgaaaggct tctacccctc cgacattgcc      900

gtggaatggg agtccaacgg ccagcctgag aacaactaca agaccacccc ccctgtgctg      960

gactccgacg gctcattctt cctgtacagc aagctgacag tggacaagtc ccggtggcag     1020

cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     1080

aagtccctgt ccctgagccc cggcaaatga                                      1110


<210>  44
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1m-D2-Fc2 

<400>  44

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val 
            20                  25                  30          


Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser 
        35                  40                  45              


Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala 
    50                  55                  60                  


Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr 
65                  70                  75                  80  


Thr Val Ser Glu Thr Thr Lys Arg Glu Asn Met Asp Phe Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys 
            100                 105                 110         


Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr 
        115                 120                 125             


Glu Leu Ser Val Arg Ala Lys Pro Ser Glu Pro Lys Ser Ser Gly Pro 
    130                 135                 140                 


Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser 
145                 150                 155                 160 


His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly 
                165                 170                 175     


Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser 
            180                 185                 190         


Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu 
        195                 200                 205             


Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln 
    210                 215                 220                 


Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


