                         SEQUENCE LISTING

<110>  еһҽԺ
 
<120>  CAR.IL-33-TƱӦ

<130>  172304

<160>  20    

<170>  PatentIn version 3.3

<210>  1
<211>  384
<212>  DNA
<213>  Artificial

<220>
<223>  ɱVLı

<400>  1
gacacactcc tgctatgggt gctgctgctc tgggttccag gttccacagg tgacattgtg     60

ctgacccaat ctccagcttc tttggctgtg tctcttgggc agagggccac catgtcctgc    120

agagccggtg aaagtgttga tatttttggc gttgggtttt tgcactggta ccagcagaaa    180

ccaggacagc cacccaaact cctcatctat cgtgcatcca acctagaatc tgggatccct    240

gtcaggttca gtggcactgg gtctaggaca gacttcaccc tcatcattga tcctgtggag    300

gctgatgatg ttgccaccta ttactgtcag caaactaatg aggatccgta cacgttcgga    360

ggggggacca agctggaaat aaaa                                           384


<210>  2
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  ɱVHı

<400>  2
agcagcgagg ttcagctaca acagtctggg gcagagcttg tggagccagg ggcctcagtc     60

aagttgtcct gcacagcttc tggcttcaac attaaagaca cctatatgca ctgggtgaag    120

cagaggcctg aacagggcct ggaatggatt ggaaggattg atcctgcgaa tggtaatagt    180

aaatatgtcc cgaagttcca gggcaaggcc actataacag cagacacatc ctccaacaca    240

gcctacctgc agctcaccag cctgacatcc gaggacactg ccgtctatta ttgtgctccg    300

tttggttact acgtgtctga ctatgctatg gcctactggg gtcaaggaac ctcagtcacc    360

gtctcctca                                                            369


<210>  3
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  ߿ԭCEAĵ壨scFvı

<400>  3
gacacactcc tgctatgggt gctgctgctc tgggttccag gttccacagg tgacattgtg     60

ctgacccaat ctccagcttc tttggctgtg tctcttgggc agagggccac catgtcctgc    120

agagccggtg aaagtgttga tatttttggc gttgggtttt tgcactggta ccagcagaaa    180

ccaggacagc cacccaaact cctcatctat cgtgcatcca acctagaatc tgggatccct    240

gtcaggttca gtggcactgg gtctaggaca gacttcaccc tcatcattga tcctgtggag    300

gctgatgatg ttgccaccta ttactgtcag caaactaatg aggatccgta cacgttcgga    360

ggggggacca agctggaaat aaaaggcagt actagcggcg gtggctccgg gggcggttcc    420

ggtgggggcg gcagcagcga ggttcagcta caacagtctg gggcagagct tgtggagcca    480

ggggcctcag tcaagttgtc ctgcacagct tctggcttca acattaaaga cacctatatg    540

cactgggtga agcagaggcc tgaacagggc ctggaatgga ttggaaggat tgatcctgcg    600

aatggtaata gtaaatatgt cccgaagttc cagggcaagg ccactataac agcagacaca    660

tcctccaaca cagcctacct gcagctcacc agcctgacat ccgaggacac tgccgtctat    720

tattgtgctc cgtttggtta ctacgtgtct gactatgcta tggcctactg gggtcaagga    780

acctcagtca ccgtctcctc a                                              801


<210>  4
<211>  84
<212>  DNA
<213>  Artificial

<220>
<223>  CD28ĤCD28-TMı

<400>  4
atgttctggg tgctggtggt ggtgggcggg gtgctggcct gctacagcct gctggtgaca     60

gtggccttca tcatcttttg ggtg                                            84


<210>  5
<211>  141
<212>  DNA
<213>  Artificial

<220>
<223>  4-1BBı

<400>  5
cgtttctctg ttgttaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     60

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa    120

gaagaaggag gatgtgaact g                                              141


<210>  6
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD3Ƶı

<400>  6
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg     60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc    120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac    180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg    240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc    300

tacgacgccc tgcacatgca ggccctgccc ccaagg                              336


<210>  7
<211>  687
<212>  DNA
<213>  Artificial

<220>
<223>  򵰰IgG4Ƭεı

<400>  7
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc     60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag    120

gtgacctgcg tggtggtgga cgtgagccag gaagatcccg aggtccagtt caattggtac    180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc    240

acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa    300

tacaagtgca aggtgtccaa caagggcctg cccagcagca tcgaaaagac catcagcaag    360

gccaagggcc agcctcgcga gccccaggtg tacaccctgc ctccctccca ggaagagatg    420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc    480

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg    540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag    600

gaaggcaacg tctttagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag    660

aagagcctga gcctgtccct gggcaag                                        687


<210>  8
<211>  2109
<212>  DNA
<213>  Artificial

<220>
<223>  CEA.CARı

<400>  8
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt     60

gacacactcc tgctatgggt gctgctgctc tgggttccag gttccacagg tgacattgtg    120

ctgacccaat ctccagcttc tttggctgtg tctcttgggc agagggccac catgtcctgc    180

agagccggtg aaagtgttga tatttttggc gttgggtttt tgcactggta ccagcagaaa    240

ccaggacagc cacccaaact cctcatctat cgtgcatcca acctagaatc tgggatccct    300

gtcaggttca gtggcactgg gtctaggaca gacttcaccc tcatcattga tcctgtggag    360

gctgatgatg ttgccaccta ttactgtcag caaactaatg aggatccgta cacgttcgga    420

ggggggacca agctggaaat aaaaggcagt actagcggcg gtggctccgg gggcggttcc    480

ggtgggggcg gcagcagcga ggttcagcta caacagtctg gggcagagct tgtggagcca    540

ggggcctcag tcaagttgtc ctgcacagct tctggcttca acattaaaga cacctatatg    600

cactgggtga agcagaggcc tgaacagggc ctggaatgga ttggaaggat tgatcctgcg    660

aatggtaata gtaaatatgt cccgaagttc cagggcaagg ccactataac agcagacaca    720

tcctccaaca cagcctacct gcagctcacc agcctgacat ccgaggacac tgccgtctat    780

tattgtgctc cgtttggtta ctacgtgtct gactatgcta tggcctactg gggtcaagga    840

acctcagtca ccgtctcctc agagagcaag tacggccctc cctgcccccc ttgccctgcc    900

cccgagttcc tgggcggacc cagcgtgttc ctgttccccc ccaagcccaa ggacaccctg    960

atgatcagcc ggacccccga ggtgacctgc gtggtggtgg acgtgagcca ggaagatccc   1020

gaggtccagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc   1080

agagaggaac agttcaacag cacctaccgg gtggtgtctg tgctgaccgt gctgcaccag   1140

gactggctga acggcaaaga atacaagtgc aaggtgtcca acaagggcct gcccagcagc   1200

atcgaaaaga ccatcagcaa ggccaagggc cagcctcgcg agccccaggt gtacaccctg   1260

cctccctccc aggaagagat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc   1320

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac   1380

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag ccggctgacc   1440

gtggacaaga gccggtggca ggaaggcaac gtctttagct gcagcgtgat gcacgaggcc   1500

ctgcacaacc actacaccca gaagagcctg agcctgtccc tgggcaagat gttctgggtg   1560

ctggtggtgg tgggcggggt gctggcctgc tacagcctgc tggtgacagt ggccttcatc   1620

atcttttggg tgcgtttctc tgttgttaaa cggggcagaa agaaactcct gtatatattc   1680

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1740

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac   1800

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg   1860

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct   1920

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag   1980

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg   2040

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg   2100

cccccaagg                                                           2109


<210>  9
<211>  704
<212>  PRT
<213>  Artificial

<220>
<223>  CEA.CARİ

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
            20                  25                  30          


Pro Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
        35                  40                  45              


Ala Val Ser Leu Gly Gln Arg Ala Thr Met Ser Cys Arg Ala Gly Glu 
    50                  55                  60                  


Ser Val Asp Ile Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
                85                  90                  95      


Ser Gly Ile Pro Val Arg Phe Ser Gly Thr Gly Ser Arg Thr Asp Phe 
            100                 105                 110         


Thr Leu Ile Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
        115                 120                 125             


Cys Gln Gln Thr Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
                165                 170                 175     


Leu Val Glu Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly 
            180                 185                 190         


Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Lys Gln Arg Pro Glu 
        195                 200                 205             


Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser 
    210                 215                 220                 


Lys Tyr Val Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr 
225                 230                 235                 240 


Ser Ser Asn Thr Ala Tyr Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp 
                245                 250                 255     


Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr 
            260                 265                 270         


Ala Met Ala Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
        275                 280                 285             


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        515                 520                 525             


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    530                 535                 540                 


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
545                 550                 555                 560 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                565                 570                 575     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            580                 585                 590         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        595                 600                 605             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    610                 615                 620                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
625                 630                 635                 640 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                645                 650                 655     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            660                 665                 670         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        675                 680                 685             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu 
    690                 695                 700                 


<210>  10
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  ߿ԭCEAĵ壨scFvİ

<400>  10

Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
1               5                   10                  15      


Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
            20                  25                  30          


Gly Gln Arg Ala Thr Met Ser Cys Arg Ala Gly Glu Ser Val Asp Ile 
        35                  40                  45              


Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Thr Gly Ser Arg Thr Asp Phe Thr Leu Ile Ile 
                85                  90                  95      


Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr 
            100                 105                 110         


Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys 
                165                 170                 175     


Asp Thr Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu 
            180                 185                 190         


Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro 
        195                 200                 205             


Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210>  11
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  ߿ԭCEAĵ壨scFvɱİ

<400>  11

Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr 
1               5                   10                  15      


Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 
            20                  25                  30          


Gly Gln Arg Ala Thr Met Ser Cys Arg Ala Gly Glu Ser Val Asp Ile 
        35                  40                  45              


Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Thr Gly Ser Arg Thr Asp Phe Thr Leu Ile Ile 
                85                  90                  95      


Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr 
            100                 105                 110         


Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210>  12
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  ߿ԭCEAĵ壨scFvɱİ

<400>  12

Ser Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys 
            20                  25                  30          


Asp Thr Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro 
    50                  55                  60                  


Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  CD28ĤCD28-TMİ

<400>  13

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  14
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BBİ

<400>  14

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  15
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD3Ƶİ

<400>  15

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  16
<211>  229
<212>  PRT
<213>  Artificial

<220>
<223>  򵰰IgG4Ƭεİ

<400>  16

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  17
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  t2Aı

<400>  17
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctcgc        57


<210>  18
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  Human IL-33ı

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctagcct tgctgctcca cgccgccagg     60

ccgagtatca caggaatttc acctattaca gagtatcttg cttctctaag cacatacaat    120

gatcaatcca ttacttttgc tttggaggat gaaagttatg agatatatgt tgaagacttg    180

aaaaaagatg aaaagaaaga taaggtgtta ctgagttact atgagtctca acacccctca    240

aatgaatcag gtgacggtgt tgatggtaag atgttaatgg taaccctgag tcctacaaaa    300

gacttctggt tgcatgccaa caacaaggaa cactctgtgg agctccataa gtgtgaaaaa    360

ccactgccag accaggcctt ctttgtcctt cataatatgc actccaactg tgtttcattt    420

gaatgcaaga ctgatcctgg agtgtttata ggtgtaaagg ataatcatct tgctctgatt    480

aaagtagact cttctgagaa tttgtgtact gaaaatatct tgtttaagct ctctgaaact    540

tag                                                                  543


<210>  19
<211>  2724
<212>  DNA
<213>  Artificial

<220>
<223>  CEA.CAR.IL-33ȫ

<400>  19
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt     60

gacacactcc tgctatgggt gctgctgctc tgggttccag gttccacagg tgacattgtg    120

ctgacccaat ctccagcttc tttggctgtg tctcttgggc agagggccac catgtcctgc    180

agagccggtg aaagtgttga tatttttggc gttgggtttt tgcactggta ccagcagaaa    240

ccaggacagc cacccaaact cctcatctat cgtgcatcca acctagaatc tgggatccct    300

gtcaggttca gtggcactgg gtctaggaca gacttcaccc tcatcattga tcctgtggag    360

gctgatgatg ttgccaccta ttactgtcag caaactaatg aggatccgta cacgttcgga    420

ggggggacca agctggaaat aaaaggcagt actagcggcg gtggctccgg gggcggttcc    480

ggtgggggcg gcagcagcga ggttcagcta caacagtctg gggcagagct tgtggagcca    540

ggggcctcag tcaagttgtc ctgcacagct tctggcttca acattaaaga cacctatatg    600

cactgggtga agcagaggcc tgaacagggc ctggaatgga ttggaaggat tgatcctgcg    660

aatggtaata gtaaatatgt cccgaagttc cagggcaagg ccactataac agcagacaca    720

tcctccaaca cagcctacct gcagctcacc agcctgacat ccgaggacac tgccgtctat    780

tattgtgctc cgtttggtta ctacgtgtct gactatgcta tggcctactg gggtcaagga    840

acctcagtca ccgtctcctc agagagcaag tacggccctc cctgcccccc ttgccctgcc    900

cccgagttcc tgggcggacc cagcgtgttc ctgttccccc ccaagcccaa ggacaccctg    960

atgatcagcc ggacccccga ggtgacctgc gtggtggtgg acgtgagcca ggaagatccc   1020

gaggtccagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc   1080

agagaggaac agttcaacag cacctaccgg gtggtgtctg tgctgaccgt gctgcaccag   1140

gactggctga acggcaaaga atacaagtgc aaggtgtcca acaagggcct gcccagcagc   1200

atcgaaaaga ccatcagcaa ggccaagggc cagcctcgcg agccccaggt gtacaccctg   1260

cctccctccc aggaagagat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc   1320

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac   1380

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag ccggctgacc   1440

gtggacaaga gccggtggca ggaaggcaac gtctttagct gcagcgtgat gcacgaggcc   1500

ctgcacaacc actacaccca gaagagcctg agcctgtccc tgggcaagat gttctgggtg   1560

ctggtggtgg tgggcggggt gctggcctgc tacagcctgc tggtgacagt ggccttcatc   1620

atcttttggg tgcgtttctc tgttgttaaa cggggcagaa agaaactcct gtatatattc   1680

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga   1740

tttccagaag aagaagaagg aggatgtgaa ctgcgggtga agttcagcag aagcgccgac   1800

gcccctgcct accagcaggg ccagaatcag ctgtacaacg agctgaacct gggcagaagg   1860

gaagagtacg acgtcctgga taagcggaga ggccgggacc ctgagatggg cggcaagcct   1920

cggcggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag   1980

gcctacagcg agatcggcat gaagggcgag cggaggcggg gcaagggcca cgacggcctg   2040

tatcagggcc tgtccaccgc caccaaggat acctacgacg ccctgcacat gcaggccctg   2100

cccccaaggc tcgagggcgg cggagagggc agaggaagtc ttctaacatg cggtgacgtg   2160

gaggagaatc ccggccctcg catggcctta ccagtgaccg ccttgctcct gccgctagcc   2220

ttgctgctcc acgccgccag gccgagtatc acaggaattt cacctattac agagtatctt   2280

gcttctctaa gcacatacaa tgatcaatcc attacttttg ctttggagga tgaaagttat   2340

gagatatatg ttgaagactt gaaaaaagat gaaaagaaag ataaggtgtt actgagttac   2400

tatgagtctc aacacccctc aaatgaatca ggtgacggtg ttgatggtaa gatgttaatg   2460

gtaaccctga gtcctacaaa agacttctgg ttgcatgcca acaacaagga acactctgtg   2520

gagctccata agtgtgaaaa accactgcca gaccaggcct tctttgtcct tcataatatg   2580

cactccaact gtgtttcatt tgaatgcaag actgatcctg gagtgtttat aggtgtaaag   2640

gataatcatc ttgctctgat taaagtagac tcttctgaga atttgtgtac tgaaaatatc   2700

ttgtttaagc tctctgaaac ttag                                          2724


<210>  20
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Human IL-33İ

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr 
            20                  25                  30          


Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu 
        35                  40                  45              


Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu 
    50                  55                  60                  


Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser 
65                  70                  75                  80  


Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu 
                85                  90                  95      


Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser 
            100                 105                 110         


Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe 
        115                 120                 125             


Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr 
    130                 135                 140                 


Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile 
145                 150                 155                 160 


Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys 
                165                 170                 175     


Leu Ser Glu Thr 
            180 


