                         SEQUENCE LISTING

<110>  Weiner, David B
       Muthumani, Kar
       Duperret, Elizabeth
       Wise, Megan
 
<120>  CTLA4 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR 
       IMMUNOTHERAPY

<130>  206194-0012-00-WO.607169

<150>  US 62/502,410
<151>  2017-05-05

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  3393
<212>  DNA
<213>  Homo sapiens

<400>  1
cccagggccc ccaggtgcag agccgtgcgg agcctgctgc ggagccacta ccgggaggtg       60

ctgcccctgg ccaccttcgt gcggaggctg ggccctcagg ggtggcggct ggtgcagaga      120

ggcgaccctg ccgccttcag agccctggtg gcccagtgcc tggtgtgcgt gccctgggac      180

gccagacctc cccctgccgc ccctagcttc cggcaggtgt cctgcctgaa agaactggtg      240

gcccgggtgc tgcagcggct gtgcgagagg ggcgccaaga acgtgctggc cttcggcttc      300

gccctgctgg acggcgccag aggcggccct cccgaggcct tcaccacctc cgtgagaagc      360

tacctgccca acaccgtgac cgacgccctg agaggcagcg gcgcttgggg cctgctgctg      420

cgcagagtgg gcgacgacgt gctggtgcac ctgctggcca gatgcgccct gttcgtgctg      480

gtcgccccca gctgcgccta ccaggtgtgc ggcccacccc tgtaccagct gggagccgcc      540

acccaggcca gaccccctcc tcacgcctcc ggccccaggc ggagactggg ctgcgagcgg      600

gcctggaacc acagcgtgcg ggaggccggc gtgcccctgg gcctgccagc ccctggcgcc      660

agaagaaggg gcggcagcgc cagcagaagc ctgcccctgc ccaagcggcc cagacgcgga      720

gccgcccctg agcccgagag aacccccgtg ggccagggct cttgggccca ccctggccgg      780

accagaggcc ccagcgaccg gggcttctgc gtggtgtccc ccgccagacc cgccgaggaa      840

gccacctccc tggaaggcgc cctgagcggc accaggcaca gccaccccag cgtgggccgc      900

cagcaccacg ccggaccccc cagcacctcc aggcccccca ggccctggga caccccttgc      960

ccccctgtgt acgccgagac caagcacttc ctgtacagca gcggcgacaa agagcagctg     1020

cggcccagct tcctgctgtc cagcctgagg ccctccctga ccggcgctag gcgcctggtg     1080

gagaccatct ttctgggcag ccggccctgg atgcccggca cccccaggcg gctgcccagg     1140

ctgccccagc ggtactggca gatgaggcct ctgttcctgg aactgctggg caaccacgcc     1200

cagtgcccct acggcgtgct gctgaaaacc cactgccccc tgagagccgc cgtgacccca     1260

gccgccggag tgtgcgccag agagaagcct cagggcagcg tggccgctcc cgaggaagag     1320

gacaccgacc ccagacgcct ggtgcagctg ctgcggcagc acagcagccc ttggcaggtg     1380

tacggcttcg tgcgggcctg cctgagaagg ctggtgcccc ctggcctgtg gggcagcagg     1440

cacaacgagc ggcggtttct gcggaacacc aagaagttca tcagcctggg gaagcacgcc     1500

aagctgtccc tgcaggaact gacctggaag atgagcgtgc ggggctgcgc ctggctgaga     1560

agatcccctg gcgtgggctg cgtgcctgcc gccgagcacc ggctgcggga ggaaatcctg     1620

gccaagttcc tgcactggct gatgagcgtg tacgtggtgg agctgctgag atccttcttc     1680

tacgtgaccg agaccacctt ccagaagaac tacctgttct tctaccggaa gagcgtgtgg     1740

agcaagctgc agagcatcgg catccggcag cacctgaagc gggtgcagct gagagagctg     1800

tccgaggccg aagtgaggca gcaccgggag gccagacctg ccctgctgac cagccggctg     1860

cggttcatcc ccaagcccga cggcctgcgg cccatcgtga acatggacta cgtggtgggc     1920

gccaggacct tccggcggga gaagcgggcc gagcggctga cctcgagggt gaaggccctg     1980

ttcagcgtgc tgaactacga gcgggccagg cggccaggcc tgctgggcgc cagcgtgctg     2040

ggcctggacg acatccaccg ggcctggcgg accttcgtgc tgagagtgcg ggcccaggac     2100

ccccctcccg agctgtactt cgtgaaggtg gacgtgacag gcgcctacga caccatcccc     2160

caggaccggc tgaccgaggt gatcgccagc atcatcaagc cccagaacac ctactgcgtg     2220

cggagatacg ccgtggtgca gaaggccgcc cacggccacg tgcggaaggc cttcaagagc     2280

cacgtgagca ccctgaccga cctgcagccc tacatgcggc agttcgtggc ccacctgcag     2340

gaaaccagcc ccctgcggga tgccgtggtg atcgagcaga gcagcagcct gaacgaggcc     2400

agcagcggcc tgttcgacgt gttcctgaga ttcatgtgcc accacgccgt gcggatccgg     2460

ggcaagagct acgtgcagtg ccagggcatc ccacagggca gcatcctgtc caccctgctg     2520

tgctccctgt gctacggcga catggaaaac aagctgttcg ccggcatcag gcgggacgga     2580

ctgctgctga gactggtgga cgacttcctg ctggtgaccc cccacctgac ccacgccaag     2640

acctttctgc ggaccctggt gcgcggcgtg cccgagtacg gctgcgtggt gaacctgaga     2700

aagaccgtgg tgaacttccc cgtggaggac gaggccctgg gcggcacagc cttcgtgcag     2760

atgcctgccc atggactgtt cccttggtgc gggctgctgc tggacacccg gaccctggaa     2820

gtgcagagcg actacagcag ctacgcccgg accagcatcc gggcctccct gaccttcaac     2880

aggggcttca aggccggcag gaacatgcgg cggaagctgt ttggcgtgct gcggctgaag     2940

tgccacagcc tgtttctgta cctgcaggtg aacagcctgc agaccgtgtg caccaacatc     3000

tacaagatcc tgctgctgca ggcctaccgg ttccacgcct gcgtgctgca gctgcccttt     3060

caccagcagg tgtggaagaa ccctaccttc ttcctgcggg tgatcagcga caccgccagc     3120

ctgtgctaca gcatcctgaa ggccaagaac gccggcatga gcctgggcgc caagggagcc     3180

gccggacctc tgcccagcga ggccgtgcag tggctgtgcc accaggcctt tctgctgaag     3240

ctgacccggc accgggtgac ctacgtgccc ctgctgggca gcctgcggac cgcccagacc     3300

cagctgtccc ggaagctgcc tggcaccacc ctgacagccc tggaagccgc cgccaacccc     3360

gccctgccct ccgacttcaa gaccatcctg gac                                  3393


<210>  2
<211>  1131
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser His 
1               5                   10                  15      


Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly Pro 
            20                  25                  30          


Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg Ala 
        35                  40                  45              


Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro Pro 
    50                  55                  60                  


Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu Val 
65                  70                  75                  80  


Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val Leu 
                85                  90                  95      


Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro Glu 
            100                 105                 110         


Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr Asp 
        115                 120                 125             


Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val Gly 
    130                 135                 140                 


Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val Leu 
145                 150                 155                 160 


Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr Gln 
                165                 170                 175     


Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly Pro 
            180                 185                 190         


Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg Glu 
        195                 200                 205             


Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg Gly 
    210                 215                 220                 


Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg Gly 
225                 230                 235                 240 


Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp Ala 
                245                 250                 255     


His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val Val 
            260                 265                 270         


Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala Leu 
        275                 280                 285             


Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His Ala 
    290                 295                 300                 


Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro Cys 
305                 310                 315                 320 


Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly Asp 
                325                 330                 335     


Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro Ser 
            340                 345                 350         


Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser Arg 
        355                 360                 365             


Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln Arg 
    370                 375                 380                 


Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His Ala 
385                 390                 395                 400 


Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg Ala 
                405                 410                 415     


Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln Gly 
            420                 425                 430         


Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu Val 
        435                 440                 445             


Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe Val 
    450                 455                 460                 


Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser Arg 
465                 470                 475                 480 


His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser Leu 
                485                 490                 495     


Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met Ser 
            500                 505                 510         


Val Arg Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys Val 
        515                 520                 525             


Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe Leu 
    530                 535                 540                 


His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe Phe 
545                 550                 555                 560 


Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Tyr Leu Phe Phe Tyr Arg 
                565                 570                 575     


Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His Leu 
            580                 585                 590         


Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln His 
        595                 600                 605             


Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro 
    610                 615                 620                 


Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val Gly 
625                 630                 635                 640 


Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser Arg 
                645                 650                 655     


Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro 
            660                 665                 670         


Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala 
        675                 680                 685             


Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu 
    690                 695                 700                 


Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile Pro 
705                 710                 715                 720 


Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln Asn 
                725                 730                 735     


Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His Gly 
            740                 745                 750         


His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp Leu 
        755                 760                 765             


Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser Pro 
    770                 775                 780                 


Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu Ala 
785                 790                 795                 800 


Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His Ala 
                805                 810                 815     


Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro Gln 
            820                 825                 830         


Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp Met 
        835                 840                 845             


Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu Arg 
    850                 855                 860                 


Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala Lys 
865                 870                 875                 880 


Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys Val 
                885                 890                 895     


Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu Ala 
            900                 905                 910         


Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe Pro 
        915                 920                 925             


Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser Asp 
    930                 935                 940                 


Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe Asn 
945                 950                 955                 960 


Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly Val 
                965                 970                 975     


Leu Arg Leu Lys Cys His Ser Leu Phe Leu Tyr Leu Gln Val Asn Ser 
            980                 985                 990         


Leu Gln Thr Val Cys Thr Asn Ile  Tyr Lys Ile Leu Leu  Leu Gln Ala 
        995                 1000                 1005             


Tyr Arg  Phe His Ala Cys Val  Leu Gln Leu Pro Phe  His Gln Gln 
    1010                 1015                 1020             


Val Trp  Lys Asn Pro Thr Phe  Phe Leu Arg Val Ile  Ser Asp Thr 
    1025                 1030                 1035             


Ala Ser  Leu Cys Tyr Ser Ile  Leu Lys Ala Lys Asn  Ala Gly Met 
    1040                 1045                 1050             


Ser Leu  Gly Ala Lys Gly Ala  Ala Gly Pro Leu Pro  Ser Glu Ala 
    1055                 1060                 1065             


Val Gln  Trp Leu Cys His Gln  Ala Phe Leu Leu Lys  Leu Thr Arg 
    1070                 1075                 1080             


His Arg  Val Thr Tyr Val Pro  Leu Leu Gly Ser Leu  Arg Thr Ala 
    1085                 1090                 1095             


Gln Thr  Gln Leu Ser Arg Lys  Leu Pro Gly Thr Thr  Leu Thr Ala 
    1100                 1105                 1110             


Leu Glu  Ala Ala Ala Asn Pro  Ala Leu Pro Ser Asp  Phe Lys Thr 
    1115                 1120                 1125             


Ile Leu  Asp 
    1130     


<210>  3
<211>  3447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, hTERT nucleic acid sequence operably 
       linked to a sequence encoding an IgE leader sequence

<400>  3
atggactgga cctggatcct gttcctggtg gccgctgcca caagagtgca cagccccagg       60

gcccccaggt gcagagccgt gcggagcctg ctgcggagcc actaccggga ggtgctgccc      120

ctggccacct tcgtgcggag gctgggccct caggggtggc ggctggtgca gagaggcgac      180

cctgccgcct tcagagccct ggtggcccag tgcctggtgt gcgtgccctg ggacgccaga      240

cctccccctg ccgcccctag cttccggcag gtgtcctgcc tgaaagaact ggtggcccgg      300

gtgctgcagc ggctgtgcga gaggggcgcc aagaacgtgc tggccttcgg cttcgccctg      360

ctggacggcg ccagaggcgg ccctcccgag gccttcacca cctccgtgag aagctacctg      420

cccaacaccg tgaccgacgc cctgagaggc agcggcgctt ggggcctgct gctgcgcaga      480

gtgggcgacg acgtgctggt gcacctgctg gccagatgcg ccctgttcgt gctggtcgcc      540

cccagctgcg cctaccaggt gtgcggccca cccctgtacc agctgggagc cgccacccag      600

gccagacccc ctcctcacgc ctccggcccc aggcggagac tgggctgcga gcgggcctgg      660

aaccacagcg tgcgggaggc cggcgtgccc ctgggcctgc cagcccctgg cgccagaaga      720

aggggcggca gcgccagcag aagcctgccc ctgcccaagc ggcccagacg cggagccgcc      780

cctgagcccg agagaacccc cgtgggccag ggctcttggg cccaccctgg ccggaccaga      840

ggccccagcg accggggctt ctgcgtggtg tcccccgcca gacccgccga ggaagccacc      900

tccctggaag gcgccctgag cggcaccagg cacagccacc ccagcgtggg ccgccagcac      960

cacgccggac cccccagcac ctccaggccc cccaggccct gggacacccc ttgcccccct     1020

gtgtacgccg agaccaagca cttcctgtac agcagcggcg acaaagagca gctgcggccc     1080

agcttcctgc tgtccagcct gaggccctcc ctgaccggcg ctaggcgcct ggtggagacc     1140

atctttctgg gcagccggcc ctggatgccc ggcaccccca ggcggctgcc caggctgccc     1200

cagcggtact ggcagatgag gcctctgttc ctggaactgc tgggcaacca cgcccagtgc     1260

ccctacggcg tgctgctgaa aacccactgc cccctgagag ccgccgtgac cccagccgcc     1320

ggagtgtgcg ccagagagaa gcctcagggc agcgtggccg ctcccgagga agaggacacc     1380

gaccccagac gcctggtgca gctgctgcgg cagcacagca gcccttggca ggtgtacggc     1440

ttcgtgcggg cctgcctgag aaggctggtg ccccctggcc tgtggggcag caggcacaac     1500

gagcggcggt ttctgcggaa caccaagaag ttcatcagcc tggggaagca cgccaagctg     1560

tccctgcagg aactgacctg gaagatgagc gtgcggggct gcgcctggct gagaagatcc     1620

cctggcgtgg gctgcgtgcc tgccgccgag caccggctgc gggaggaaat cctggccaag     1680

ttcctgcact ggctgatgag cgtgtacgtg gtggagctgc tgagatcctt cttctacgtg     1740

accgagacca ccttccagaa gaactacctg ttcttctacc ggaagagcgt gtggagcaag     1800

ctgcagagca tcggcatccg gcagcacctg aagcgggtgc agctgagaga gctgtccgag     1860

gccgaagtga ggcagcaccg ggaggccaga cctgccctgc tgaccagccg gctgcggttc     1920

atccccaagc ccgacggcct gcggcccatc gtgaacatgg actacgtggt gggcgccagg     1980

accttccggc gggagaagcg ggccgagcgg ctgacctcga gggtgaaggc cctgttcagc     2040

gtgctgaact acgagcgggc caggcggcca ggcctgctgg gcgccagcgt gctgggcctg     2100

gacgacatcc accgggcctg gcggaccttc gtgctgagag tgcgggccca ggacccccct     2160

cccgagctgt acttcgtgaa ggtggacgtg acaggcgcct acgacaccat cccccaggac     2220

cggctgaccg aggtgatcgc cagcatcatc aagccccaga acacctactg cgtgcggaga     2280

tacgccgtgg tgcagaaggc cgcccacggc cacgtgcgga aggccttcaa gagccacgtg     2340

agcaccctga ccgacctgca gccctacatg cggcagttcg tggcccacct gcaggaaacc     2400

agccccctgc gggatgccgt ggtgatcgag cagagcagca gcctgaacga ggccagcagc     2460

ggcctgttcg acgtgttcct gagattcatg tgccaccacg ccgtgcggat ccggggcaag     2520

agctacgtgc agtgccaggg catcccacag ggcagcatcc tgtccaccct gctgtgctcc     2580

ctgtgctacg gcgacatgga aaacaagctg ttcgccggca tcaggcggga cggactgctg     2640

ctgagactgg tggacgactt cctgctggtg accccccacc tgacccacgc caagaccttt     2700

ctgcggaccc tggtgcgcgg cgtgcccgag tacggctgcg tggtgaacct gagaaagacc     2760

gtggtgaact tccccgtgga ggacgaggcc ctgggcggca cagccttcgt gcagatgcct     2820

gcccatggac tgttcccttg gtgcgggctg ctgctggaca cccggaccct ggaagtgcag     2880

agcgactaca gcagctacgc ccggaccagc atccgggcct ccctgacctt caacaggggc     2940

ttcaaggccg gcaggaacat gcggcggaag ctgtttggcg tgctgcggct gaagtgccac     3000

agcctgtttc tgtacctgca ggtgaacagc ctgcagaccg tgtgcaccaa catctacaag     3060

atcctgctgc tgcaggccta ccggttccac gcctgcgtgc tgcagctgcc ctttcaccag     3120

caggtgtgga agaaccctac cttcttcctg cgggtgatca gcgacaccgc cagcctgtgc     3180

tacagcatcc tgaaggccaa gaacgccggc atgagcctgg gcgccaaggg agccgccgga     3240

cctctgccca gcgaggccgt gcagtggctg tgccaccagg cctttctgct gaagctgacc     3300

cggcaccggg tgacctacgt gcccctgctg ggcagcctgc ggaccgccca gacccagctg     3360

tcccggaagc tgcctggcac caccctgaca gccctggaag ccgccgccaa ccccgccctg     3420

ccctccgact tcaagaccat cctggac                                         3447


<210>  4
<211>  1149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, hTERT amino acid sequence operably linked
       to an IgE leader sequence

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg 
            20                  25                  30          


Ser His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu 
        35                  40                  45              


Gly Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe 
    50                  55                  60                  


Arg Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg 
65                  70                  75                  80  


Pro Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu 
                85                  90                  95      


Leu Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn 
            100                 105                 110         


Val Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val 
    130                 135                 140                 


Thr Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg 
145                 150                 155                 160 


Val Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe 
                165                 170                 175     


Val Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu 
            180                 185                 190         


Tyr Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser 
        195                 200                 205             


Gly Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val 
    210                 215                 220                 


Arg Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg 
225                 230                 235                 240 


Arg Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg 
                245                 250                 255     


Arg Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser 
            260                 265                 270         


Trp Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys 
        275                 280                 285             


Val Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly 
    290                 295                 300                 


Ala Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His 
305                 310                 315                 320 


His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr 
                325                 330                 335     


Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser 
            340                 345                 350         


Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg 
        355                 360                 365             


Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly 
    370                 375                 380                 


Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro 
385                 390                 395                 400 


Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn 
                405                 410                 415     


His Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu 
            420                 425                 430         


Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro 
        435                 440                 445             


Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg 
    450                 455                 460                 


Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly 
465                 470                 475                 480 


Phe Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly 
                485                 490                 495     


Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile 
            500                 505                 510         


Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys 
        515                 520                 525             


Met Ser Val Arg Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly 
    530                 535                 540                 


Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys 
545                 550                 555                 560 


Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser 
                565                 570                 575     


Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Tyr Leu Phe Phe 
            580                 585                 590         


Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln 
        595                 600                 605             


His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg 
    610                 615                 620                 


Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe 
625                 630                 635                 640 


Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val 
                645                 650                 655     


Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr 
            660                 665                 670         


Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg 
        675                 680                 685             


Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His 
    690                 695                 700                 


Arg Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro 
705                 710                 715                 720 


Pro Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr 
                725                 730                 735     


Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro 
            740                 745                 750         


Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala 
        755                 760                 765             


His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr 
    770                 775                 780                 


Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr 
785                 790                 795                 800 


Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn 
                805                 810                 815     


Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His 
            820                 825                 830         


His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile 
        835                 840                 845             


Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly 
    850                 855                 860                 


Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu 
865                 870                 875                 880 


Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His 
                885                 890                 895     


Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly 
            900                 905                 910         


Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp 
        915                 920                 925             


Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu 
    930                 935                 940                 


Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln 
945                 950                 955                 960 


Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                965                 970                 975     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            980                 985                 990         


Gly Val Leu Arg Leu Lys Cys His  Ser Leu Phe Leu Tyr  Leu Gln Val 
        995                 1000                 1005             


Asn Ser  Leu Gln Thr Val Cys  Thr Asn Ile Tyr Lys  Ile Leu Leu 
    1010                 1015                 1020             


Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val Leu Gln  Leu Pro Phe 
    1025                 1030                 1035             


His Gln  Gln Val Trp Lys Asn  Pro Thr Phe Phe Leu  Arg Val Ile 
    1040                 1045                 1050             


Ser Asp  Thr Ala Ser Leu Cys  Tyr Ser Ile Leu Lys  Ala Lys Asn 
    1055                 1060                 1065             


Ala Gly  Met Ser Leu Gly Ala  Lys Gly Ala Ala Gly  Pro Leu Pro 
    1070                 1075                 1080             


Ser Glu  Ala Val Gln Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys 
    1085                 1090                 1095             


Leu Thr  Arg His Arg Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu 
    1100                 1105                 1110             


Arg Thr  Ala Gln Thr Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr 
    1115                 1120                 1125             


Leu Thr  Ala Leu Glu Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp 
    1130                 1135                 1140             


Phe Lys  Thr Ile Leu Asp 
    1145                 


<210>  5
<211>  3383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Synthetic Consensus hTERT nucleic acid 
       sequence (pgx1434)

<400>  5
cacggtgtag agcagtccgc agcctgctgc gcagccgata ccgggaagtg ctgcctctgg       60

ccacctttgt ccggagactg ggaccacagg gcaggcgcct ggtgcagcgc ggcgaccccg      120

cagctttccg agcactggtg gcacagtgcc tggtgtgcgt gccatgggat gcacggcccc      180

ctccagcagc ccctagcttt agacaggtgt cctgcctgaa agaactggtc gcaagggtgg      240

tccagcggct gtgcgagaga ggcgccagga acgtgctggc attcggcttt gcactgctgg      300

acggagctag gggcgggccc cctgaggcat tcaccacaag cgtgcgctcc tacctgccaa      360

atacagtcac tgataccctg cgaggctccg gagcatgggg actgctgctg cgacgggtgg      420

gggacgatgt gctggtccac ctgctggcta gatgcgcact gtatgtgctg gtcgctccct      480

cttgcgcata ccaggtgtgc ggaccacccc tgtatgacct gggcgctgca acccaggcaa      540

gacctccacc ccacgcctct ggcactagaa ggggactggg caccgaacag gcatggaacc      600

atagtgtcag ggaggcagga gtgccactgg gactgccagc acctggggct cgccgacgga      660

gagggagtgc cggacggtca ctgccactgg ctaagagacc aaggcgcgga gccgctccag      720

aaccagagag gacacctgtg ggacagggaa gctgggcaca ccctggaaga actagggggc      780

caagtgatag gggcttctgc gtggtctcac cagcacgacc agcagaggaa gctacttctc      840

tggagggagc tctgagtggc acccggcact ctcatcctag tgtgggaaga cagcaccatg      900

caggccctcc aagcaccagc cggcctcccc ggccatggga cactccttgt ccacccgtgt      960

acgctgaaac caaacacttt ctgtatagct ccggagataa ggagcagctg cggccctctt     1020

tcctgctgtc tagtctgaga cctagtctga ccggagcacg acggctggtg gaaacaatct     1080

ttctggggtc ccgcccttgg atgccaggaa cccccagaag gacacctcga ctgccacagc     1140

ggtactggca gatgcggcca ctgttcctgg agctgctggg caatcacgct cagtgcccct     1200

atggggcact gctgcgaaca cattgtcctc tgcgggcagc cgtgactcca gctgcaggag     1260

tctgcgccag ggaaaagcca cagggcagcg tggcagctcc tgaggaagag gacaccgatc     1320

cacgccgact ggtgcagctg ctgagacagc actcaagccc ctggcaggtg tacggatttc     1380

tgagggcctg tctgcggaga ctggtgcctc caggactgtg ggggtccagg cacaacgaaa     1440

ggcgctttct gcgcaatact aagaaattca tcagcctggg caagcatgct aaactgtccc     1500

tgcaggagct gacctggaaa atgagtgtgc gcgactgcgc atggctgcga cggtcaccag     1560

gagtcgggtg cgtgcctgca gccgagcacc gcctgcgaga agagattctg gccaagtttc     1620

tgcattggct gatgtcagtg tacgtggtcg aactgctgcg gagcttcttt tatgtgacag     1680

agactacctt ccagaaaaac tacctgttct tttatcgcaa gtcagtgtgg agcaaactgc     1740

agtcaatcgg cattcggcag cacctgaaga gagtgcagct gagggaactg agtgaagccg     1800

aggtccggca gcatagagag gcaaggcctg ccctgctgac ctcccggctg agattcctgc     1860

ctaagccaga cgggctgaga ccaatcgtga acatggatta cgtggtcgga gcacggacct     1920

tccggaggga aaaacgcgct gagcgactga catcccgcgt gaagactctg ttctctgtcc     1980

tgaattatga gcgagctcgc cgacccggac tgctgggagc atctgtgctg ggactggacg     2040

atattcaccg ggcttggaga gcatttgtcc tgagggtgcg cgcacaggac cctcccccag     2100

aactgtactt cgtgaaagtc gccgtgaccg gggcttatga cacaatccct caggatcggc     2160

tgactgaagt gatcgcctcc atcattaagc cacagaatac ctactgcgtg cggagatatg     2220

ctgtggtcag gcgcgctgca cacggccatg tgaggaagag cttcaagcgc cacgtcagca     2280

cactgactga tctgcagccc tacatgagac agttcgtggc tcatctgcag gagaccagcc     2340

ctctgaggga cgcagtggtc atcgaacagt cctctagtct gaacgaggca tcaagcgggc     2400

tgttcgatgt ctttctgcgg ttcgtgtgcc accatgccgt cagaattgga ggcaaatctt     2460

acgtgcagtg tcagggcatc ccccagggca gcattctgtc taccctgctg tgcagcctgt     2520

gctatggcga catggaaaat aagctgtttg ccggaatccg acgggatggc ctgctgctga     2580

gactggtggc cgcttttctg ctggtcactc cacacctgac ccatgccaaa gctttcctgc     2640

gcacactggt ccgaggggtg ccagagtacg gatgcgtggt caacctgagg aagaccgtgg     2700

tcaatttccc agtggaagac gaggccctgg gcggcacagc atttgtccag ctgccagcac     2760

acggactgtt cccatggtgt ggactgctgc tggacacccg cacactggag gtgcagtccg     2820

attactcctc ttatgcccgg acaagcatca gagcttccct gacttttaac agaggcttca     2880

aggccgggag gaatatgaga aggaaactgt ttggcgtgct gcgcctgaag tgccattccc     2940

tgttcctgta tctgcaggtg aactctctgc agactgtctg taccaacgtg tacaaaattt     3000

ttctgctgca ggcctatcgg ttccacgctt gcgtgctgca gctgccattc catcagcagg     3060

tcaggaagaa ccccaccttc tttctgcgcg tgatctctga tacagctagt ctgtgctact     3120

caattctgaa ggccaaaaat gctggcatga gcctgggagc aaaaggagca gcaggaccat     3180

ttccttccga ggctgcacag tggctgtgcc accaggcatt cctgctgaag ctggcccgac     3240

atcgggtgac atataggtgc ctgctgggcg cactgcgaac agcacagact cagctgtgca     3300

gaaagctgcc cggggccact ctggctgccc tggaagccgc tgccgaccct gccctgacct     3360

ccgatttcaa gactattctg gac                                             3383


<210>  6
<211>  1131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Synthetic consensus hTERT amino acid 
       sequence (pgx 1434)

<400>  6

Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser Arg 
1               5                   10                  15      


Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly Pro 
            20                  25                  30          


Gln Gly Arg Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg Ala 
        35                  40                  45              


Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro Pro 
    50                  55                  60                  


Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu Val 
65                  70                  75                  80  


Ala Arg Val Val Gln Arg Leu Cys Glu Arg Gly Ala Arg Asn Val Leu 
                85                  90                  95      


Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro Glu 
            100                 105                 110         


Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr Asp 
        115                 120                 125             


Thr Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val Gly 
    130                 135                 140                 


Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Tyr Val Leu 
145                 150                 155                 160 


Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr Asp 
                165                 170                 175     


Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly Thr 
            180                 185                 190         


Arg Arg Gly Leu Gly Thr Glu Gln Ala Trp Asn His Ser Val Arg Glu 
        195                 200                 205             


Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg Arg 
    210                 215                 220                 


Gly Ser Ala Gly Arg Ser Leu Pro Leu Ala Lys Arg Pro Arg Arg Gly 
225                 230                 235                 240 


Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp Ala 
                245                 250                 255     


His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val Val 
            260                 265                 270         


Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala Leu 
        275                 280                 285             


Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His Ala 
    290                 295                 300                 


Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro Cys 
305                 310                 315                 320 


Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly Asp 
                325                 330                 335     


Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro Ser 
            340                 345                 350         


Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser Arg 
        355                 360                 365             


Pro Trp Met Pro Gly Thr Pro Arg Arg Thr Pro Arg Leu Pro Gln Arg 
    370                 375                 380                 


Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His Ala 
385                 390                 395                 400 


Gln Cys Pro Tyr Gly Ala Leu Leu Arg Thr His Cys Pro Leu Arg Ala 
                405                 410                 415     


Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln Gly 
            420                 425                 430         


Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu Val 
        435                 440                 445             


Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe Leu 
    450                 455                 460                 


Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser Arg 
465                 470                 475                 480 


His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser Leu 
                485                 490                 495     


Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met Ser 
            500                 505                 510         


Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys Val 
        515                 520                 525             


Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe Leu 
    530                 535                 540                 


His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe Phe 
545                 550                 555                 560 


Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Tyr Leu Phe Phe Tyr Arg 
                565                 570                 575     


Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His Leu 
            580                 585                 590         


Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln His 
        595                 600                 605             


Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Leu Pro 
    610                 615                 620                 


Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val Gly 
625                 630                 635                 640 


Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser Arg 
                645                 650                 655     


Val Lys Thr Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro 
            660                 665                 670         


Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala 
        675                 680                 685             


Trp Arg Ala Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu 
    690                 695                 700                 


Leu Tyr Phe Val Lys Val Ala Val Thr Gly Ala Tyr Asp Thr Ile Pro 
705                 710                 715                 720 


Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln Asn 
                725                 730                 735     


Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Arg Arg Ala Ala His Gly 
            740                 745                 750         


His Val Arg Lys Ser Phe Lys Arg His Val Ser Thr Leu Thr Asp Leu 
        755                 760                 765             


Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser Pro 
    770                 775                 780                 


Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu Ala 
785                 790                 795                 800 


Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Val Cys His His Ala 
                805                 810                 815     


Val Arg Ile Gly Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro Gln 
            820                 825                 830         


Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp Met 
        835                 840                 845             


Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu Arg 
    850                 855                 860                 


Leu Val Ala Ala Phe Leu Leu Val Thr Pro His Leu Thr His Ala Lys 
865                 870                 875                 880 


Ala Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys Val 
                885                 890                 895     


Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu Ala 
            900                 905                 910         


Leu Gly Gly Thr Ala Phe Val Gln Leu Pro Ala His Gly Leu Phe Pro 
        915                 920                 925             


Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser Asp 
    930                 935                 940                 


Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe Asn 
945                 950                 955                 960 


Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly Val 
                965                 970                 975     


Leu Arg Leu Lys Cys His Ser Leu Phe Leu Tyr Leu Gln Val Asn Ser 
            980                 985                 990         


Leu Gln Thr Val Cys Thr Asn Val  Tyr Lys Ile Phe Leu  Leu Gln Ala 
        995                 1000                 1005             


Tyr Arg  Phe His Ala Cys Val  Leu Gln Leu Pro Phe  His Gln Gln 
    1010                 1015                 1020             


Val Arg  Lys Asn Pro Thr Phe  Phe Leu Arg Val Ile  Ser Asp Thr 
    1025                 1030                 1035             


Ala Ser  Leu Cys Tyr Ser Ile  Leu Lys Ala Lys Asn  Ala Gly Met 
    1040                 1045                 1050             


Ser Leu  Gly Ala Lys Gly Ala  Ala Gly Pro Phe Pro  Ser Glu Ala 
    1055                 1060                 1065             


Ala Gln  Trp Leu Cys His Gln  Ala Phe Leu Leu Lys  Leu Ala Arg 
    1070                 1075                 1080             


His Arg  Val Thr Tyr Arg Cys  Leu Leu Gly Ala Leu  Arg Thr Ala 
    1085                 1090                 1095             


Gln Thr  Gln Leu Cys Arg Lys  Leu Pro Gly Ala Thr  Leu Ala Ala 
    1100                 1105                 1110             


Leu Glu  Ala Ala Ala Asp Pro  Ala Leu Thr Ser Asp  Phe Lys Thr 
    1115                 1120                 1125             


Ile Leu  Asp 
    1130     


<210>  7
<211>  3447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Synthetic Consensus hTERT nucleic acid 
       sequence (pgx1434), operably linked to a sequence encoding an IgE
       leader sequence

<400>  7
atggattgga catggattct gttcctggtc gcagccgcca cacgagtgca tagccctaga       60

gccccacggt gtagagcagt ccgcagcctg ctgcgcagcc gataccggga agtgctgcct      120

ctggccacct ttgtccggag actgggacca cagggcaggc gcctggtgca gcgcggcgac      180

cccgcagctt tccgagcact ggtggcacag tgcctggtgt gcgtgccatg ggatgcacgg      240

ccccctccag cagcccctag ctttagacag gtgtcctgcc tgaaagaact ggtcgcaagg      300

gtggtccagc ggctgtgcga gagaggcgcc aggaacgtgc tggcattcgg ctttgcactg      360

ctggacggag ctaggggcgg gccccctgag gcattcacca caagcgtgcg ctcctacctg      420

ccaaatacag tcactgatac cctgcgaggc tccggagcat ggggactgct gctgcgacgg      480

gtgggggacg atgtgctggt ccacctgctg gctagatgcg cactgtatgt gctggtcgct      540

ccctcttgcg cataccaggt gtgcggacca cccctgtatg acctgggcgc tgcaacccag      600

gcaagacctc caccccacgc ctctggcact agaaggggac tgggcaccga acaggcatgg      660

aaccatagtg tcagggaggc aggagtgcca ctgggactgc cagcacctgg ggctcgccga      720

cggagaggga gtgccggacg gtcactgcca ctggctaaga gaccaaggcg cggagccgct      780

ccagaaccag agaggacacc tgtgggacag ggaagctggg cacaccctgg aagaactagg      840

gggccaagtg ataggggctt ctgcgtggtc tcaccagcac gaccagcaga ggaagctact      900

tctctggagg gagctctgag tggcacccgg cactctcatc ctagtgtggg aagacagcac      960

catgcaggcc ctccaagcac cagccggcct ccccggccat gggacactcc ttgtccaccc     1020

gtgtacgctg aaaccaaaca ctttctgtat agctccggag ataaggagca gctgcggccc     1080

tctttcctgc tgtctagtct gagacctagt ctgaccggag cacgacggct ggtggaaaca     1140

atctttctgg ggtcccgccc ttggatgcca ggaaccccca gaaggacacc tcgactgcca     1200

cagcggtact ggcagatgcg gccactgttc ctggagctgc tgggcaatca cgctcagtgc     1260

ccctatgggg cactgctgcg aacacattgt cctctgcggg cagccgtgac tccagctgca     1320

ggagtctgcg ccagggaaaa gccacagggc agcgtggcag ctcctgagga agaggacacc     1380

gatccacgcc gactggtgca gctgctgaga cagcactcaa gcccctggca ggtgtacgga     1440

tttctgaggg cctgtctgcg gagactggtg cctccaggac tgtgggggtc caggcacaac     1500

gaaaggcgct ttctgcgcaa tactaagaaa ttcatcagcc tgggcaagca tgctaaactg     1560

tccctgcagg agctgacctg gaaaatgagt gtgcgcgact gcgcatggct gcgacggtca     1620

ccaggagtcg ggtgcgtgcc tgcagccgag caccgcctgc gagaagagat tctggccaag     1680

tttctgcatt ggctgatgtc agtgtacgtg gtcgaactgc tgcggagctt cttttatgtg     1740

acagagacta ccttccagaa aaactacctg ttcttttatc gcaagtcagt gtggagcaaa     1800

ctgcagtcaa tcggcattcg gcagcacctg aagagagtgc agctgaggga actgagtgaa     1860

gccgaggtcc ggcagcatag agaggcaagg cctgccctgc tgacctcccg gctgagattc     1920

ctgcctaagc cagacgggct gagaccaatc gtgaacatgg attacgtggt cggagcacgg     1980

accttccgga gggaaaaacg cgctgagcga ctgacatccc gcgtgaagac tctgttctct     2040

gtcctgaatt atgagcgagc tcgccgaccc ggactgctgg gagcatctgt gctgggactg     2100

gacgatattc accgggcttg gagagcattt gtcctgaggg tgcgcgcaca ggaccctccc     2160

ccagaactgt acttcgtgaa agtcgccgtg accggggctt atgacacaat ccctcaggat     2220

cggctgactg aagtgatcgc ctccatcatt aagccacaga atacctactg cgtgcggaga     2280

tatgctgtgg tcaggcgcgc tgcacacggc catgtgagga agagcttcaa gcgccacgtc     2340

agcacactga ctgatctgca gccctacatg agacagttcg tggctcatct gcaggagacc     2400

agccctctga gggacgcagt ggtcatcgaa cagtcctcta gtctgaacga ggcatcaagc     2460

gggctgttcg atgtctttct gcggttcgtg tgccaccatg ccgtcagaat tggaggcaaa     2520

tcttacgtgc agtgtcaggg catcccccag ggcagcattc tgtctaccct gctgtgcagc     2580

ctgtgctatg gcgacatgga aaataagctg tttgccggaa tccgacggga tggcctgctg     2640

ctgagactgg tggccgcttt tctgctggtc actccacacc tgacccatgc caaagctttc     2700

ctgcgcacac tggtccgagg ggtgccagag tacggatgcg tggtcaacct gaggaagacc     2760

gtggtcaatt tcccagtgga agacgaggcc ctgggcggca cagcatttgt ccagctgcca     2820

gcacacggac tgttcccatg gtgtggactg ctgctggaca cccgcacact ggaggtgcag     2880

tccgattact cctcttatgc ccggacaagc atcagagctt ccctgacttt taacagaggc     2940

ttcaaggccg ggaggaatat gagaaggaaa ctgtttggcg tgctgcgcct gaagtgccat     3000

tccctgttcc tgtatctgca ggtgaactct ctgcagactg tctgtaccaa cgtgtacaaa     3060

atttttctgc tgcaggccta tcggttccac gcttgcgtgc tgcagctgcc attccatcag     3120

caggtcagga agaaccccac cttctttctg cgcgtgatct ctgatacagc tagtctgtgc     3180

tactcaattc tgaaggccaa aaatgctggc atgagcctgg gagcaaaagg agcagcagga     3240

ccatttcctt ccgaggctgc acagtggctg tgccaccagg cattcctgct gaagctggcc     3300

cgacatcggg tgacatatag gtgcctgctg ggcgcactgc gaacagcaca gactcagctg     3360

tgcagaaagc tgcccggggc cactctggct gccctggaag ccgctgccga ccctgccctg     3420

acctccgatt tcaagactat tctggac                                         3447


<210>  8
<211>  1149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Synthetic consensus hTERT amino acid 
       sequence (pgx 1434) operably linked to an IgE leader sequence

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg 
            20                  25                  30          


Ser Arg Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu 
        35                  40                  45              


Gly Pro Gln Gly Arg Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe 
    50                  55                  60                  


Arg Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg 
65                  70                  75                  80  


Pro Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu 
                85                  90                  95      


Leu Val Ala Arg Val Val Gln Arg Leu Cys Glu Arg Gly Ala Arg Asn 
            100                 105                 110         


Val Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val 
    130                 135                 140                 


Thr Asp Thr Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg 
145                 150                 155                 160 


Val Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Tyr 
                165                 170                 175     


Val Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu 
            180                 185                 190         


Tyr Asp Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser 
        195                 200                 205             


Gly Thr Arg Arg Gly Leu Gly Thr Glu Gln Ala Trp Asn His Ser Val 
    210                 215                 220                 


Arg Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg 
225                 230                 235                 240 


Arg Arg Gly Ser Ala Gly Arg Ser Leu Pro Leu Ala Lys Arg Pro Arg 
                245                 250                 255     


Arg Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser 
            260                 265                 270         


Trp Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys 
        275                 280                 285             


Val Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly 
    290                 295                 300                 


Ala Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His 
305                 310                 315                 320 


His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr 
                325                 330                 335     


Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser 
            340                 345                 350         


Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg 
        355                 360                 365             


Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly 
    370                 375                 380                 


Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Thr Pro Arg Leu Pro 
385                 390                 395                 400 


Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn 
                405                 410                 415     


His Ala Gln Cys Pro Tyr Gly Ala Leu Leu Arg Thr His Cys Pro Leu 
            420                 425                 430         


Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro 
        435                 440                 445             


Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg 
    450                 455                 460                 


Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly 
465                 470                 475                 480 


Phe Leu Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly 
                485                 490                 495     


Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile 
            500                 505                 510         


Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys 
        515                 520                 525             


Met Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly 
    530                 535                 540                 


Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys 
545                 550                 555                 560 


Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser 
                565                 570                 575     


Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Tyr Leu Phe Phe 
            580                 585                 590         


Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln 
        595                 600                 605             


His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg 
    610                 615                 620                 


Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe 
625                 630                 635                 640 


Leu Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val 
                645                 650                 655     


Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr 
            660                 665                 670         


Ser Arg Val Lys Thr Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg 
        675                 680                 685             


Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His 
    690                 695                 700                 


Arg Ala Trp Arg Ala Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro 
705                 710                 715                 720 


Pro Glu Leu Tyr Phe Val Lys Val Ala Val Thr Gly Ala Tyr Asp Thr 
                725                 730                 735     


Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro 
            740                 745                 750         


Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Arg Arg Ala Ala 
        755                 760                 765             


His Gly His Val Arg Lys Ser Phe Lys Arg His Val Ser Thr Leu Thr 
    770                 775                 780                 


Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr 
785                 790                 795                 800 


Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn 
                805                 810                 815     


Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Val Cys His 
            820                 825                 830         


His Ala Val Arg Ile Gly Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile 
        835                 840                 845             


Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly 
    850                 855                 860                 


Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu 
865                 870                 875                 880 


Leu Arg Leu Val Ala Ala Phe Leu Leu Val Thr Pro His Leu Thr His 
                885                 890                 895     


Ala Lys Ala Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly 
            900                 905                 910         


Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp 
        915                 920                 925             


Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Leu Pro Ala His Gly Leu 
    930                 935                 940                 


Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln 
945                 950                 955                 960 


Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                965                 970                 975     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            980                 985                 990         


Gly Val Leu Arg Leu Lys Cys His  Ser Leu Phe Leu Tyr  Leu Gln Val 
        995                 1000                 1005             


Asn Ser  Leu Gln Thr Val Cys  Thr Asn Val Tyr Lys  Ile Phe Leu 
    1010                 1015                 1020             


Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val Leu Gln  Leu Pro Phe 
    1025                 1030                 1035             


His Gln  Gln Val Arg Lys Asn  Pro Thr Phe Phe Leu  Arg Val Ile 
    1040                 1045                 1050             


Ser Asp  Thr Ala Ser Leu Cys  Tyr Ser Ile Leu Lys  Ala Lys Asn 
    1055                 1060                 1065             


Ala Gly  Met Ser Leu Gly Ala  Lys Gly Ala Ala Gly  Pro Phe Pro 
    1070                 1075                 1080             


Ser Glu  Ala Ala Gln Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys 
    1085                 1090                 1095             


Leu Ala  Arg His Arg Val Thr  Tyr Arg Cys Leu Leu  Gly Ala Leu 
    1100                 1105                 1110             


Arg Thr  Ala Gln Thr Gln Leu  Cys Arg Lys Leu Pro  Gly Ala Thr 
    1115                 1120                 1125             


Leu Ala  Ala Leu Glu Ala Ala  Ala Asp Pro Ala Leu  Thr Ser Asp 
    1130                 1135                 1140             


Phe Lys  Thr Ile Leu Asp 
    1145                 


<210>  9
<211>  3363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, synthetic, consensus mouse TERT (mTERT) 
       nucleic acid sequence (pgx1418)

<400>  9
ccaagagccc ccaggtgccc tgctgtgagg tcactgctcc gaagcaggta cagagaagtg       60

tggcccctgg ccacattcgt caggagactg ggacctgaag ggcggcgcct ggtgcagcca      120

ggtgacccca aggtgtttag aactctggtc gctcagtgcc tggtgtgcgt gccatggggg      180

tctcagcccc ctccagcaga tctgagtttc caccaggtga gctccctgaa ggagctcgtc      240

gcccgagtgg tccagaggct gtgcgagaga ggcgaacgga acgtgctggc tttcggtttt      300

gcactgctca atggagcccg cggcggaccc cctatggctt tcaccacatc tgtgaggagt      360

tacctgccca actctgtgac cgagagtctg agagtctcag gagcttggat gctgctcctg      420

agccgggtgg gggacgatct cctggtctac ctcctggctc attgcgcact gtatctcctg      480

gtgccaccct catgcgccta ccaggtctgt ggaagcccac tgtatcagat ctgtgccact      540

accgacacct ggccaagcgt gagcgccagc taccgaccta cccgaccagt cggacggaac      600

ttcacaaatc tggggtccct ccaccagatt aagaattcta gtcatcagga ggcccctaaa      660

ccactcgctc tgccctccag agggacaaag cggcacctct ctctgacctc cacatctgtg      720

cctagtgcca agaaagctcg atgctatccc gcccctaggg tcgaaaaggg tcctcatcgc      780

caggtggtcc caacaccctc tggcaaaact tgggtgccta gcccagcaag gtccccagag      840

gtccctactg ccgaaaagga cctgtcaagc aagggtaaag ctagcgatct cagtctgtca      900

ggcagcgtgt gctgtaagca caaaccatcc tctacctcac tcctgagccc tccaaggcag      960

aacgccttcc agctgagacc ctttactgag acccggcatt tcctgtacag ccgcgggggt     1020

ggccaggaac gactgaatcc ttcctttctc ctgaacaatc tgcagccatc tctcaccggc     1080

gctcgaaggc tggtggagat cattttcctc ggttcccggc cacgcacatc tggacctctg     1140

tgcagaacta gacggctctc ccgccgatac tggcagatgc ggccactgtt ccagcagctc     1200

ctggtgaacc acgccgaatg ccagtatgtc aggctcctga gatctcattg taggttcagg     1260

actgcaaacc agcaggtgac cgacgccctg aatacaagcc ctccccacct gatggatctc     1320

ctgcgcctcc atagttcacc atggcaggtg tacggattcc tgcgagcttg cctgcgaaag     1380

ctcgtcccag caggtctgtg gggcacaagg cacaacgaga ggagattctt taaaaacgtg     1440

aagaagttca tctcactggg aaagtatggg aaactcagcc tgcaggagct gatgtggaag     1500

atgaaagtgg aagactgtca ctggctgagg agctccccag gcaaggatag agtgcccgcc     1560

gctgagcata gactgcggga acgcatcctc gccatgttcc tgttttggct catggacaca     1620

tacgtggtcc agctcctgcg cagcttcttt tatattactg agacaacttt ccagaagaac     1680

aggctgttct tttacagaaa gtccgtgtgg tctaaactgc agtctatcgg ggtgagacag     1740

cacctggagc gagtcaggct gagagaactc agtcaggagg aagtgcggca ccatcaggat     1800

acatggctgg ccatgcctat ctgccggctg cgcttcattc ccaagcctaa cggcctgagg     1860

ccaattgtga atatgtccta ttctatggga actcgggctt ttgggaagcg caaacaggca     1920

cagcacttca ctcagcgcct gaagaccctc tttagcgtgc tgaactacga gaggactaaa     1980

catcccaatc tgatgggtgc ttccgtgctc ggcatgaacg acatctatcg aacctggcga     2040

gccttcgtgc tgcgagtcag ggctctcgac cagaccccta gaatgtactt tgtgaaggcc     2100

gatgtcacag gagcatatga cgccattcca caggataaac tggtggaggt ggtcgctaat     2160

atgatccggc acagtgaatc aacctactgt attcggcagt atgcagtggt ccagcgagac     2220

agccagggac aggtgcataa gtccttccgg cgccaggtca gtacactgtc agatctccag     2280

ccctacatgg gacagtttct gaaacacctc caggacagcg atgcctccgc tctgagaaac     2340

agcgtggtca tcgagcagag catttccatg aatgaatcta gttcaagcct gttcgacttc     2400

tttctccact ttgtgcgcca ttccgtggtc aagatcggag ggcgatgcta tgtccagtgt     2460

cagggtattc ctcagggctc ctctctgagt accctcctgt gctcactgtg cttcggagac     2520

atggagaaca agctgtttgc tgaagtgcag caggatgggc tcctgctccg gttcgtggca     2580

gcctttctgc tcgtcactcc ccacctggat caggcaaagg ccttcctgtc caccctcgtg     2640

catggagtcc ctgagtacgg gtgcatgatc aacctgcaga aaactgtggt caattttcca     2700

gtggaaccag gcaccctggg tggcgctgca cctcaccagc tgccagccca ttgcctcttc     2760

ccttggtgtg gtctgctcct ggacacacag actctggagg tgttttgtga ttactccggc     2820

tatgccagga cctctatcaa gactagtctg accttccaga gcgtgttcaa ggctggaaaa     2880

acaatgcgat acaagctcct gtcagtgctc aggctgaaat gccacgggct cttcctggac     2940

ctccaggtga actctctgca gaccgtctgt atcaatatct acaagatctt cctcctgcag     3000

gcatatagat ttcacgcctg cgtgattcag ctgcctttcg atcagcatgt ccggaaaaac     3060

ctggccttct ttctcggaat catttcaaat caggctagct gctgttatgc aatcctgaag     3120

gtgaaaaacc caggaatgac actgaaggca aaagggtcct tcccacccga ggccgctaga     3180

tggctgtgct accaggcctt tctcctgaag ctggcagccc actctgtgac atataaatgc     3240

ctcctgggcc ctctgagaac tgcacagaag cagctgtgcc ggaaactccc agaagccacc     3300

atgacaatcc tgaagaccgc tgcagacccc gctctctcca ctgatttcca gaccattctc     3360

gac                                                                   3363


<210>  10
<211>  1121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, synthetic, consensus mTERT amino acid 
       sequence (pGX1418)

<400>  10

Pro Arg Ala Pro Arg Cys Pro Ala Val Arg Ser Leu Leu Arg Ser Arg 
1               5                   10                  15      


Tyr Arg Glu Val Trp Pro Leu Ala Thr Phe Val Arg Arg Leu Gly Pro 
            20                  25                  30          


Glu Gly Arg Arg Leu Val Gln Pro Gly Asp Pro Lys Val Phe Arg Thr 
        35                  40                  45              


Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Gly Ser Gln Pro Pro 
    50                  55                  60                  


Pro Ala Asp Leu Ser Phe His Gln Val Ser Ser Leu Lys Glu Leu Val 
65                  70                  75                  80  


Ala Arg Val Val Gln Arg Leu Cys Glu Arg Gly Glu Arg Asn Val Leu 
                85                  90                  95      


Ala Phe Gly Phe Ala Leu Leu Asn Gly Ala Arg Gly Gly Pro Pro Met 
            100                 105                 110         


Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Ser Val Thr Glu 
        115                 120                 125             


Ser Leu Arg Val Ser Gly Ala Trp Met Leu Leu Leu Ser Arg Val Gly 
    130                 135                 140                 


Asp Asp Leu Leu Val Tyr Leu Leu Ala His Cys Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Val Pro Pro Ser Cys Ala Tyr Gln Val Cys Gly Ser Pro Leu Tyr Gln 
                165                 170                 175     


Ile Cys Ala Thr Thr Asp Thr Trp Pro Ser Val Ser Ala Ser Tyr Arg 
            180                 185                 190         


Pro Thr Arg Pro Val Gly Arg Asn Phe Thr Asn Leu Gly Ser Leu His 
        195                 200                 205             


Gln Ile Lys Asn Ser Ser His Gln Glu Ala Pro Lys Pro Leu Ala Leu 
    210                 215                 220                 


Pro Ser Arg Gly Thr Lys Arg His Leu Ser Leu Thr Ser Thr Ser Val 
225                 230                 235                 240 


Pro Ser Ala Lys Lys Ala Arg Cys Tyr Pro Ala Pro Arg Val Glu Lys 
                245                 250                 255     


Gly Pro His Arg Gln Val Val Pro Thr Pro Ser Gly Lys Thr Trp Val 
            260                 265                 270         


Pro Ser Pro Ala Arg Ser Pro Glu Val Pro Thr Ala Glu Lys Asp Leu 
        275                 280                 285             


Ser Ser Lys Gly Lys Ala Ser Asp Leu Ser Leu Ser Gly Ser Val Cys 
    290                 295                 300                 


Cys Lys His Lys Pro Ser Ser Thr Ser Leu Leu Ser Pro Pro Arg Gln 
305                 310                 315                 320 


Asn Ala Phe Gln Leu Arg Pro Phe Thr Glu Thr Arg His Phe Leu Tyr 
                325                 330                 335     


Ser Arg Gly Gly Gly Gln Glu Arg Leu Asn Pro Ser Phe Leu Leu Asn 
            340                 345                 350         


Asn Leu Gln Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Ile Ile 
        355                 360                 365             


Phe Leu Gly Ser Arg Pro Arg Thr Ser Gly Pro Leu Cys Arg Thr Arg 
    370                 375                 380                 


Arg Leu Ser Arg Arg Tyr Trp Gln Met Arg Pro Leu Phe Gln Gln Leu 
385                 390                 395                 400 


Leu Val Asn His Ala Glu Cys Gln Tyr Val Arg Leu Leu Arg Ser His 
                405                 410                 415     


Cys Arg Phe Arg Thr Ala Asn Gln Gln Val Thr Asp Ala Leu Asn Thr 
            420                 425                 430         


Ser Pro Pro His Leu Met Asp Leu Leu Arg Leu His Ser Ser Pro Trp 
        435                 440                 445             


Gln Val Tyr Gly Phe Leu Arg Ala Cys Leu Arg Lys Leu Val Pro Ala 
    450                 455                 460                 


Gly Leu Trp Gly Thr Arg His Asn Glu Arg Arg Phe Phe Lys Asn Val 
465                 470                 475                 480 


Lys Lys Phe Ile Ser Leu Gly Lys Tyr Gly Lys Leu Ser Leu Gln Glu 
                485                 490                 495     


Leu Met Trp Lys Met Lys Val Glu Asp Cys His Trp Leu Arg Ser Ser 
            500                 505                 510         


Pro Gly Lys Asp Arg Val Pro Ala Ala Glu His Arg Leu Arg Glu Arg 
        515                 520                 525             


Ile Leu Ala Met Phe Leu Phe Trp Leu Met Asp Thr Tyr Val Val Gln 
    530                 535                 540                 


Leu Leu Arg Ser Phe Phe Tyr Ile Thr Glu Thr Thr Phe Gln Lys Asn 
545                 550                 555                 560 


Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile 
                565                 570                 575     


Gly Val Arg Gln His Leu Glu Arg Val Arg Leu Arg Glu Leu Ser Gln 
            580                 585                 590         


Glu Glu Val Arg His His Gln Asp Thr Trp Leu Ala Met Pro Ile Cys 
        595                 600                 605             


Arg Leu Arg Phe Ile Pro Lys Pro Asn Gly Leu Arg Pro Ile Val Asn 
    610                 615                 620                 


Met Ser Tyr Ser Met Gly Thr Arg Ala Phe Gly Lys Arg Lys Gln Ala 
625                 630                 635                 640 


Gln His Phe Thr Gln Arg Leu Lys Thr Leu Phe Ser Val Leu Asn Tyr 
                645                 650                 655     


Glu Arg Thr Lys His Pro Asn Leu Met Gly Ala Ser Val Leu Gly Met 
            660                 665                 670         


Asn Asp Ile Tyr Arg Thr Trp Arg Ala Phe Val Leu Arg Val Arg Ala 
        675                 680                 685             


Leu Asp Gln Thr Pro Arg Met Tyr Phe Val Lys Ala Asp Val Thr Gly 
    690                 695                 700                 


Ala Tyr Asp Ala Ile Pro Gln Asp Lys Leu Val Glu Val Val Ala Asn 
705                 710                 715                 720 


Met Ile Arg His Ser Glu Ser Thr Tyr Cys Ile Arg Gln Tyr Ala Val 
                725                 730                 735     


Val Gln Arg Asp Ser Gln Gly Gln Val His Lys Ser Phe Arg Arg Gln 
            740                 745                 750         


Val Ser Thr Leu Ser Asp Leu Gln Pro Tyr Met Gly Gln Phe Leu Lys 
        755                 760                 765             


His Leu Gln Asp Ser Asp Ala Ser Ala Leu Arg Asn Ser Val Val Ile 
    770                 775                 780                 


Glu Gln Ser Ile Ser Met Asn Glu Ser Ser Ser Ser Leu Phe Asp Phe 
785                 790                 795                 800 


Phe Leu His Phe Val Arg His Ser Val Val Lys Ile Gly Gly Arg Cys 
                805                 810                 815     


Tyr Val Gln Cys Gln Gly Ile Pro Gln Gly Ser Ser Leu Ser Thr Leu 
            820                 825                 830         


Leu Cys Ser Leu Cys Phe Gly Asp Met Glu Asn Lys Leu Phe Ala Glu 
        835                 840                 845             


Val Gln Gln Asp Gly Leu Leu Leu Arg Phe Val Ala Ala Phe Leu Leu 
    850                 855                 860                 


Val Thr Pro His Leu Asp Gln Ala Lys Ala Phe Leu Ser Thr Leu Val 
865                 870                 875                 880 


His Gly Val Pro Glu Tyr Gly Cys Met Ile Asn Leu Gln Lys Thr Val 
                885                 890                 895     


Val Asn Phe Pro Val Glu Pro Gly Thr Leu Gly Gly Ala Ala Pro His 
            900                 905                 910         


Gln Leu Pro Ala His Cys Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp 
        915                 920                 925             


Thr Gln Thr Leu Glu Val Phe Cys Asp Tyr Ser Gly Tyr Ala Arg Thr 
    930                 935                 940                 


Ser Ile Lys Thr Ser Leu Thr Phe Gln Ser Val Phe Lys Ala Gly Lys 
945                 950                 955                 960 


Thr Met Arg Tyr Lys Leu Leu Ser Val Leu Arg Leu Lys Cys His Gly 
                965                 970                 975     


Leu Phe Leu Asp Leu Gln Val Asn Ser Leu Gln Thr Val Cys Ile Asn 
            980                 985                 990         


Ile Tyr Lys Ile Phe Leu Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val 
        995                 1000                 1005             


Ile Gln  Leu Pro Phe Asp Gln  His Val Arg Lys Asn  Leu Ala Phe 
    1010                 1015                 1020             


Phe Leu  Gly Ile Ile Ser Asn  Gln Ala Ser Cys Cys  Tyr Ala Ile 
    1025                 1030                 1035             


Leu Lys  Val Lys Asn Pro Gly  Met Thr Leu Lys Ala  Lys Gly Ser 
    1040                 1045                 1050             


Phe Pro  Pro Glu Ala Ala Arg  Trp Leu Cys Tyr Gln  Ala Phe Leu 
    1055                 1060                 1065             


Leu Lys  Leu Ala Ala His Ser  Val Thr Tyr Lys Cys  Leu Leu Gly 
    1070                 1075                 1080             


Pro Leu  Arg Thr Ala Gln Lys  Gln Leu Cys Arg Lys  Leu Pro Glu 
    1085                 1090                 1095             


Ala Thr  Met Thr Ile Leu Lys  Thr Ala Ala Asp Pro  Ala Leu Ser 
    1100                 1105                 1110             


Thr Asp  Phe Gln Thr Ile Leu  Asp 
    1115                 1120     


<210>  11
<211>  3417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, synthetic, consensus mTERT nucleic acid 
       sequence (pgx1418) operably linked to a sequence encoding an IgE 
       leader sequence

<400>  11
atggactgga catggattct gtttctcgtc gccgccgcta caagagtgca ttccccaaga       60

gcccccaggt gccctgctgt gaggtcactg ctccgaagca ggtacagaga agtgtggccc      120

ctggccacat tcgtcaggag actgggacct gaagggcggc gcctggtgca gccaggtgac      180

cccaaggtgt ttagaactct ggtcgctcag tgcctggtgt gcgtgccatg ggggtctcag      240

ccccctccag cagatctgag tttccaccag gtgagctccc tgaaggagct cgtcgcccga      300

gtggtccaga ggctgtgcga gagaggcgaa cggaacgtgc tggctttcgg ttttgcactg      360

ctcaatggag cccgcggcgg accccctatg gctttcacca catctgtgag gagttacctg      420

cccaactctg tgaccgagag tctgagagtc tcaggagctt ggatgctgct cctgagccgg      480

gtgggggacg atctcctggt ctacctcctg gctcattgcg cactgtatct cctggtgcca      540

ccctcatgcg cctaccaggt ctgtggaagc ccactgtatc agatctgtgc cactaccgac      600

acctggccaa gcgtgagcgc cagctaccga cctacccgac cagtcggacg gaacttcaca      660

aatctggggt ccctccacca gattaagaat tctagtcatc aggaggcccc taaaccactc      720

gctctgccct ccagagggac aaagcggcac ctctctctga cctccacatc tgtgcctagt      780

gccaagaaag ctcgatgcta tcccgcccct agggtcgaaa agggtcctca tcgccaggtg      840

gtcccaacac cctctggcaa aacttgggtg cctagcccag caaggtcccc agaggtccct      900

actgccgaaa aggacctgtc aagcaagggt aaagctagcg atctcagtct gtcaggcagc      960

gtgtgctgta agcacaaacc atcctctacc tcactcctga gccctccaag gcagaacgcc     1020

ttccagctga gaccctttac tgagacccgg catttcctgt acagccgcgg gggtggccag     1080

gaacgactga atccttcctt tctcctgaac aatctgcagc catctctcac cggcgctcga     1140

aggctggtgg agatcatttt cctcggttcc cggccacgca catctggacc tctgtgcaga     1200

actagacggc tctcccgccg atactggcag atgcggccac tgttccagca gctcctggtg     1260

aaccacgccg aatgccagta tgtcaggctc ctgagatctc attgtaggtt caggactgca     1320

aaccagcagg tgaccgacgc cctgaataca agccctcccc acctgatgga tctcctgcgc     1380

ctccatagtt caccatggca ggtgtacgga ttcctgcgag cttgcctgcg aaagctcgtc     1440

ccagcaggtc tgtggggcac aaggcacaac gagaggagat tctttaaaaa cgtgaagaag     1500

ttcatctcac tgggaaagta tgggaaactc agcctgcagg agctgatgtg gaagatgaaa     1560

gtggaagact gtcactggct gaggagctcc ccaggcaagg atagagtgcc cgccgctgag     1620

catagactgc gggaacgcat cctcgccatg ttcctgtttt ggctcatgga cacatacgtg     1680

gtccagctcc tgcgcagctt cttttatatt actgagacaa ctttccagaa gaacaggctg     1740

ttcttttaca gaaagtccgt gtggtctaaa ctgcagtcta tcggggtgag acagcacctg     1800

gagcgagtca ggctgagaga actcagtcag gaggaagtgc ggcaccatca ggatacatgg     1860

ctggccatgc ctatctgccg gctgcgcttc attcccaagc ctaacggcct gaggccaatt     1920

gtgaatatgt cctattctat gggaactcgg gcttttggga agcgcaaaca ggcacagcac     1980

ttcactcagc gcctgaagac cctctttagc gtgctgaact acgagaggac taaacatccc     2040

aatctgatgg gtgcttccgt gctcggcatg aacgacatct atcgaacctg gcgagccttc     2100

gtgctgcgag tcagggctct cgaccagacc cctagaatgt actttgtgaa ggccgatgtc     2160

acaggagcat atgacgccat tccacaggat aaactggtgg aggtggtcgc taatatgatc     2220

cggcacagtg aatcaaccta ctgtattcgg cagtatgcag tggtccagcg agacagccag     2280

ggacaggtgc ataagtcctt ccggcgccag gtcagtacac tgtcagatct ccagccctac     2340

atgggacagt ttctgaaaca cctccaggac agcgatgcct ccgctctgag aaacagcgtg     2400

gtcatcgagc agagcatttc catgaatgaa tctagttcaa gcctgttcga cttctttctc     2460

cactttgtgc gccattccgt ggtcaagatc ggagggcgat gctatgtcca gtgtcagggt     2520

attcctcagg gctcctctct gagtaccctc ctgtgctcac tgtgcttcgg agacatggag     2580

aacaagctgt ttgctgaagt gcagcaggat gggctcctgc tccggttcgt ggcagccttt     2640

ctgctcgtca ctccccacct ggatcaggca aaggccttcc tgtccaccct cgtgcatgga     2700

gtccctgagt acgggtgcat gatcaacctg cagaaaactg tggtcaattt tccagtggaa     2760

ccaggcaccc tgggtggcgc tgcacctcac cagctgccag cccattgcct cttcccttgg     2820

tgtggtctgc tcctggacac acagactctg gaggtgtttt gtgattactc cggctatgcc     2880

aggacctcta tcaagactag tctgaccttc cagagcgtgt tcaaggctgg aaaaacaatg     2940

cgatacaagc tcctgtcagt gctcaggctg aaatgccacg ggctcttcct ggacctccag     3000

gtgaactctc tgcagaccgt ctgtatcaat atctacaaga tcttcctcct gcaggcatat     3060

agatttcacg cctgcgtgat tcagctgcct ttcgatcagc atgtccggaa aaacctggcc     3120

ttctttctcg gaatcatttc aaatcaggct agctgctgtt atgcaatcct gaaggtgaaa     3180

aacccaggaa tgacactgaa ggcaaaaggg tccttcccac ccgaggccgc tagatggctg     3240

tgctaccagg cctttctcct gaagctggca gcccactctg tgacatataa atgcctcctg     3300

ggccctctga gaactgcaca gaagcagctg tgccggaaac tcccagaagc caccatgaca     3360

atcctgaaga ccgctgcaga ccccgctctc tccactgatt tccagaccat tctcgac        3417


<210>  12
<211>  1139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, synthetic, consensus mTERT amino acid 
       sequence (pGX1418) operably linked to an IgE leader sequence

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Arg Ala Pro Arg Cys Pro Ala Val Arg Ser Leu Leu Arg 
            20                  25                  30          


Ser Arg Tyr Arg Glu Val Trp Pro Leu Ala Thr Phe Val Arg Arg Leu 
        35                  40                  45              


Gly Pro Glu Gly Arg Arg Leu Val Gln Pro Gly Asp Pro Lys Val Phe 
    50                  55                  60                  


Arg Thr Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Gly Ser Gln 
65                  70                  75                  80  


Pro Pro Pro Ala Asp Leu Ser Phe His Gln Val Ser Ser Leu Lys Glu 
                85                  90                  95      


Leu Val Ala Arg Val Val Gln Arg Leu Cys Glu Arg Gly Glu Arg Asn 
            100                 105                 110         


Val Leu Ala Phe Gly Phe Ala Leu Leu Asn Gly Ala Arg Gly Gly Pro 
        115                 120                 125             


Pro Met Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Ser Val 
    130                 135                 140                 


Thr Glu Ser Leu Arg Val Ser Gly Ala Trp Met Leu Leu Leu Ser Arg 
145                 150                 155                 160 


Val Gly Asp Asp Leu Leu Val Tyr Leu Leu Ala His Cys Ala Leu Tyr 
                165                 170                 175     


Leu Leu Val Pro Pro Ser Cys Ala Tyr Gln Val Cys Gly Ser Pro Leu 
            180                 185                 190         


Tyr Gln Ile Cys Ala Thr Thr Asp Thr Trp Pro Ser Val Ser Ala Ser 
        195                 200                 205             


Tyr Arg Pro Thr Arg Pro Val Gly Arg Asn Phe Thr Asn Leu Gly Ser 
    210                 215                 220                 


Leu His Gln Ile Lys Asn Ser Ser His Gln Glu Ala Pro Lys Pro Leu 
225                 230                 235                 240 


Ala Leu Pro Ser Arg Gly Thr Lys Arg His Leu Ser Leu Thr Ser Thr 
                245                 250                 255     


Ser Val Pro Ser Ala Lys Lys Ala Arg Cys Tyr Pro Ala Pro Arg Val 
            260                 265                 270         


Glu Lys Gly Pro His Arg Gln Val Val Pro Thr Pro Ser Gly Lys Thr 
        275                 280                 285             


Trp Val Pro Ser Pro Ala Arg Ser Pro Glu Val Pro Thr Ala Glu Lys 
    290                 295                 300                 


Asp Leu Ser Ser Lys Gly Lys Ala Ser Asp Leu Ser Leu Ser Gly Ser 
305                 310                 315                 320 


Val Cys Cys Lys His Lys Pro Ser Ser Thr Ser Leu Leu Ser Pro Pro 
                325                 330                 335     


Arg Gln Asn Ala Phe Gln Leu Arg Pro Phe Thr Glu Thr Arg His Phe 
            340                 345                 350         


Leu Tyr Ser Arg Gly Gly Gly Gln Glu Arg Leu Asn Pro Ser Phe Leu 
        355                 360                 365             


Leu Asn Asn Leu Gln Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu 
    370                 375                 380                 


Ile Ile Phe Leu Gly Ser Arg Pro Arg Thr Ser Gly Pro Leu Cys Arg 
385                 390                 395                 400 


Thr Arg Arg Leu Ser Arg Arg Tyr Trp Gln Met Arg Pro Leu Phe Gln 
                405                 410                 415     


Gln Leu Leu Val Asn His Ala Glu Cys Gln Tyr Val Arg Leu Leu Arg 
            420                 425                 430         


Ser His Cys Arg Phe Arg Thr Ala Asn Gln Gln Val Thr Asp Ala Leu 
        435                 440                 445             


Asn Thr Ser Pro Pro His Leu Met Asp Leu Leu Arg Leu His Ser Ser 
    450                 455                 460                 


Pro Trp Gln Val Tyr Gly Phe Leu Arg Ala Cys Leu Arg Lys Leu Val 
465                 470                 475                 480 


Pro Ala Gly Leu Trp Gly Thr Arg His Asn Glu Arg Arg Phe Phe Lys 
                485                 490                 495     


Asn Val Lys Lys Phe Ile Ser Leu Gly Lys Tyr Gly Lys Leu Ser Leu 
            500                 505                 510         


Gln Glu Leu Met Trp Lys Met Lys Val Glu Asp Cys His Trp Leu Arg 
        515                 520                 525             


Ser Ser Pro Gly Lys Asp Arg Val Pro Ala Ala Glu His Arg Leu Arg 
    530                 535                 540                 


Glu Arg Ile Leu Ala Met Phe Leu Phe Trp Leu Met Asp Thr Tyr Val 
545                 550                 555                 560 


Val Gln Leu Leu Arg Ser Phe Phe Tyr Ile Thr Glu Thr Thr Phe Gln 
                565                 570                 575     


Lys Asn Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln 
            580                 585                 590         


Ser Ile Gly Val Arg Gln His Leu Glu Arg Val Arg Leu Arg Glu Leu 
        595                 600                 605             


Ser Gln Glu Glu Val Arg His His Gln Asp Thr Trp Leu Ala Met Pro 
    610                 615                 620                 


Ile Cys Arg Leu Arg Phe Ile Pro Lys Pro Asn Gly Leu Arg Pro Ile 
625                 630                 635                 640 


Val Asn Met Ser Tyr Ser Met Gly Thr Arg Ala Phe Gly Lys Arg Lys 
                645                 650                 655     


Gln Ala Gln His Phe Thr Gln Arg Leu Lys Thr Leu Phe Ser Val Leu 
            660                 665                 670         


Asn Tyr Glu Arg Thr Lys His Pro Asn Leu Met Gly Ala Ser Val Leu 
        675                 680                 685             


Gly Met Asn Asp Ile Tyr Arg Thr Trp Arg Ala Phe Val Leu Arg Val 
    690                 695                 700                 


Arg Ala Leu Asp Gln Thr Pro Arg Met Tyr Phe Val Lys Ala Asp Val 
705                 710                 715                 720 


Thr Gly Ala Tyr Asp Ala Ile Pro Gln Asp Lys Leu Val Glu Val Val 
                725                 730                 735     


Ala Asn Met Ile Arg His Ser Glu Ser Thr Tyr Cys Ile Arg Gln Tyr 
            740                 745                 750         


Ala Val Val Gln Arg Asp Ser Gln Gly Gln Val His Lys Ser Phe Arg 
        755                 760                 765             


Arg Gln Val Ser Thr Leu Ser Asp Leu Gln Pro Tyr Met Gly Gln Phe 
    770                 775                 780                 


Leu Lys His Leu Gln Asp Ser Asp Ala Ser Ala Leu Arg Asn Ser Val 
785                 790                 795                 800 


Val Ile Glu Gln Ser Ile Ser Met Asn Glu Ser Ser Ser Ser Leu Phe 
                805                 810                 815     


Asp Phe Phe Leu His Phe Val Arg His Ser Val Val Lys Ile Gly Gly 
            820                 825                 830         


Arg Cys Tyr Val Gln Cys Gln Gly Ile Pro Gln Gly Ser Ser Leu Ser 
        835                 840                 845             


Thr Leu Leu Cys Ser Leu Cys Phe Gly Asp Met Glu Asn Lys Leu Phe 
    850                 855                 860                 


Ala Glu Val Gln Gln Asp Gly Leu Leu Leu Arg Phe Val Ala Ala Phe 
865                 870                 875                 880 


Leu Leu Val Thr Pro His Leu Asp Gln Ala Lys Ala Phe Leu Ser Thr 
                885                 890                 895     


Leu Val His Gly Val Pro Glu Tyr Gly Cys Met Ile Asn Leu Gln Lys 
            900                 905                 910         


Thr Val Val Asn Phe Pro Val Glu Pro Gly Thr Leu Gly Gly Ala Ala 
        915                 920                 925             


Pro His Gln Leu Pro Ala His Cys Leu Phe Pro Trp Cys Gly Leu Leu 
    930                 935                 940                 


Leu Asp Thr Gln Thr Leu Glu Val Phe Cys Asp Tyr Ser Gly Tyr Ala 
945                 950                 955                 960 


Arg Thr Ser Ile Lys Thr Ser Leu Thr Phe Gln Ser Val Phe Lys Ala 
                965                 970                 975     


Gly Lys Thr Met Arg Tyr Lys Leu Leu Ser Val Leu Arg Leu Lys Cys 
            980                 985                 990         


His Gly Leu Phe Leu Asp Leu Gln  Val Asn Ser Leu Gln  Thr Val Cys 
        995                 1000                 1005             


Ile Asn  Ile Tyr Lys Ile Phe  Leu Leu Gln Ala Tyr  Arg Phe His 
    1010                 1015                 1020             


Ala Cys  Val Ile Gln Leu Pro  Phe Asp Gln His Val  Arg Lys Asn 
    1025                 1030                 1035             


Leu Ala  Phe Phe Leu Gly Ile  Ile Ser Asn Gln Ala  Ser Cys Cys 
    1040                 1045                 1050             


Tyr Ala  Ile Leu Lys Val Lys  Asn Pro Gly Met Thr  Leu Lys Ala 
    1055                 1060                 1065             


Lys Gly  Ser Phe Pro Pro Glu  Ala Ala Arg Trp Leu  Cys Tyr Gln 
    1070                 1075                 1080             


Ala Phe  Leu Leu Lys Leu Ala  Ala His Ser Val Thr  Tyr Lys Cys 
    1085                 1090                 1095             


Leu Leu  Gly Pro Leu Arg Thr  Ala Gln Lys Gln Leu  Cys Arg Lys 
    1100                 1105                 1110             


Leu Pro  Glu Ala Thr Met Thr  Ile Leu Lys Thr Ala  Ala Asp Pro 
    1115                 1120                 1125             


Ala Leu  Ser Thr Asp Phe Gln  Thr Ile Leu Asp 
    1130                 1135                 


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, amino acid sequence of an IgE leader 
       sequence

<400>  13

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


