                         SEQUENCE LISTING

<110>  Washington University
       Spitzer, Dirk
       Hawkins, William
 
<120>  MESOTHELIN-TARGETED TRAIL TRIMER

<130>  047563-594973

<150>  62/500,377
<151>  2017-05-02

<150>  62/527,598
<151>  2017-06-30

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  2
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  2

Leu Pro Pro Arg Thr Pro Pro Met Ile Leu Arg Thr Ser Glu Glu Thr 
1               5                   10                  15      


Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg 
            20                  25                  30          


Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
        35                  40                  45              


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    50                  55                  60                  


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
65                  70                  75                  80  


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                85                  90                  95      


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            100                 105                 110         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        115                 120                 125             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    130                 135                 140                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
145                 150                 155                 160 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                165                 170                 175     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            180                 185                 190         


Gly Ala Phe Leu Val Gly Arg Ser Gln Asn Ile Ser Pro Leu Val Arg 
        195                 200                 205             


Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
    210                 215                 220                 


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
225                 230                 235                 240 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
                245                 250                 255     


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
            260                 265                 270         


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
        275                 280                 285             


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
    290                 295                 300                 


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
305                 310                 315                 320 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
                325                 330                 335     


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
            340                 345                 350         


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
        355                 360                 365             


Gly Ala Phe Leu Val Gly Arg Ser Gln Asn Ile Ser Pro Leu Val Arg 
    370                 375                 380                 


Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
385                 390                 395                 400 


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
                405                 410                 415     


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
            420                 425                 430         


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
        435                 440                 445             


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
    450                 455                 460                 


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
465                 470                 475                 480 


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
                485                 490                 495     


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
            500                 505                 510         


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
        515                 520                 525             


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
    530                 535                 540                 


Gly Ala Phe Leu Val Gly Arg Ser 
545                 550         


<210>  3
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  3

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Pro Pro Arg Thr Pro Pro 
            20                  25                  30          


Met Ile Leu Arg Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys 
        35                  40                  45              


Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val 
    50                  55                  60                  


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
65                  70                  75                  80  


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
                85                  90                  95      


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
            100                 105                 110         


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
        115                 120                 125             


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
    130                 135                 140                 


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
145                 150                 155                 160 


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
                165                 170                 175     


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
            180                 185                 190         


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
        195                 200                 205             


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg 
    210                 215                 220                 


Ser Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val 
225                 230                 235                 240 


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
                245                 250                 255     


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
            260                 265                 270         


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
        275                 280                 285             


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
    290                 295                 300                 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
305                 310                 315                 320 


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
                325                 330                 335     


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
            340                 345                 350         


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
        355                 360                 365             


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
    370                 375                 380                 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg 
385                 390                 395                 400 


Ser Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val 
                405                 410                 415     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            420                 425                 430         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        435                 440                 445             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    450                 455                 460                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
465                 470                 475                 480 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                485                 490                 495     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            500                 505                 510         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        515                 520                 525             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    530                 535                 540                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
545                 550                 555                 560 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg 
                565                 570                 575     


Ser 
    


<210>  4
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  4

Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Pro Glu Ile 
1               5                   10                  15      


Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val 
            20                  25                  30          


Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro 
        35                  40                  45              


Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu 
    50                  55                  60                  


Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu 
65                  70                  75                  80  


Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser 
                85                  90                  95      


Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu Met 
            100                 105                 110         


Ser Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly 
        115                 120                 125             


Gln Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly 
    130                 135                 140                 


Tyr Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser 
145                 150                 155                 160 


Ser Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg 
                165                 170                 175     


Gln Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met 
            180                 185                 190         


Asn Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala 
        195                 200                 205             


Pro Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp 
    210                 215                 220                 


Leu Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr 
225                 230                 235                 240 


Val Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys 
                245                 250                 255     


Ala Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg 
            260                 265                 270         


Gln Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro 
        275                 280                 285             


Asn Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly 
    290                 295                 300                 


Thr Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu 
305                 310                 315                 320 


Leu Leu Ala Ser Thr Leu Ala 
                325         


<210>  5
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


Arg Ala 
        


<210>  6
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Ser 
            


<210>  7
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg Ala 
            


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  8

Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu 
            100                 105                 110         


Thr Val Leu Ser 
        115     


<210>  9
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  10

Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr 
1               5                   10                  15      


Gln Gln 
        


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  11

Asp Lys Gln Gln Gly Ser Gly 
1               5           


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  12

Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly 
1               5                   10              


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  13

Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp 
1               5                   10      


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  14

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   10  


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  15

Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  16
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  18

Glu Gly Ile Tyr His Trp 
1               5       


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  19

Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  20

Gly Tyr Ser Ile Asn Thr Tyr Tyr 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  21

Ile Asn Pro Ser Gly Val Thr 
1               5           


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  22

Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val 
1               5                   10              


<210>  23
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  23

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Pro Pro Arg Thr Gln Val 
            20                  25                  30          


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val 
        35                  40                  45              


Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met 
    50                  55                  60                  


Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val 
65                  70                  75                  80  


Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg 
                85                  90                  95      


Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu 
            100                 105                 110         


Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp 
        115                 120                 125             


Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
                165                 170                 175     


Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly 
            180                 185                 190         


Ile Tyr His Trp Leu Ala Trp Tyr Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn 
                245                 250                 255     


Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            260                 265                 270         


Arg Thr Pro Pro Met Ile Leu Arg Thr Ser Glu Glu Thr Ile Ser Thr 
        275                 280                 285             


Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly 
    290                 295                 300                 


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
305                 310                 315                 320 


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
                325                 330                 335     


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
            340                 345                 350         


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
        355                 360                 365             


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
    370                 375                 380                 


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
385                 390                 395                 400 


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
                405                 410                 415     


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
            420                 425                 430         


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
        435                 440                 445             


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
    450                 455                 460                 


Leu Val Gly Arg Ser Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly 
465                 470                 475                 480 


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
                485                 490                 495     


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
            500                 505                 510         


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
        515                 520                 525             


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
    530                 535                 540                 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
545                 550                 555                 560 


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
                565                 570                 575     


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
            580                 585                 590         


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
        595                 600                 605             


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
    610                 615                 620                 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
625                 630                 635                 640 


Leu Val Gly Arg Ser Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly 
                645                 650                 655     


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
            660                 665                 670         


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
        675                 680                 685             


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
    690                 695                 700                 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
705                 710                 715                 720 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
                725                 730                 735     


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
            740                 745                 750         


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
        755                 760                 765             


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
    770                 775                 780                 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
785                 790                 795                 800 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
                805                 810                 815     


Leu Val Gly Arg Ser 
            820     


<210>  24
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  24

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Pro Pro Arg Thr Gln Val 
            20                  25                  30          


Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu 
        35                  40                  45              


Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala 
    50                  55                  60                  


Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
65                  70                  75                  80  


Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser 
                85                  90                  95      


Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe 
            100                 105                 110         


Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
    130                 135                 140                 


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val 
                165                 170                 175     


Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser 
            180                 185                 190         


Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile 
        195                 200                 205             


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn 
    210                 215                 220                 


Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg 
225                 230                 235                 240 


Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile 
                245                 250                 255     


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp 
            260                 265                 270         


His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
        275                 280                 285             


Ser Arg Thr Pro Pro Met Ile Leu Arg Thr Ser Glu Glu Thr Ile Ser 
    290                 295                 300                 


Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg 
305                 310                 315                 320 


Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
                325                 330                 335     


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
            340                 345                 350         


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
        355                 360                 365             


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
    370                 375                 380                 


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
385                 390                 395                 400 


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
                405                 410                 415     


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
            420                 425                 430         


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
        435                 440                 445             


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
    450                 455                 460                 


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
465                 470                 475                 480 


Phe Leu Val Gly Arg Ser Gln Asn Ile Ser Pro Leu Val Arg Glu Arg 
                485                 490                 495     


Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
            500                 505                 510         


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
        515                 520                 525             


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
    530                 535                 540                 


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
545                 550                 555                 560 


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
                565                 570                 575     


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
            580                 585                 590         


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
        595                 600                 605             


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
    610                 615                 620                 


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
625                 630                 635                 640 


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
                645                 650                 655     


Phe Leu Val Gly Arg Ser Gln Asn Ile Ser Pro Leu Val Arg Glu Arg 
            660                 665                 670         


Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
        675                 680                 685             


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
    690                 695                 700                 


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
705                 710                 715                 720 


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
                725                 730                 735     


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
            740                 745                 750         


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
        755                 760                 765             


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
    770                 775                 780                 


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
785                 790                 795                 800 


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
                805                 810                 815     


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
            820                 825                 830         


Phe Leu Val Gly Arg Ser 
        835             


<210>  25
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  25

Leu Pro Pro Arg Thr Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
1               5                   10                  15      


Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr 
            20                  25                  30          


Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala 
        35                  40                  45              


Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr 
    50                  55                  60                  


Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr 
65                  70                  75                  80  


Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu 
            180                 185                 190         


Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Arg Ala Arg Thr Pro Pro Met Ile Leu Arg Thr 
                245                 250                 255     


Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser 
            260                 265                 270         


Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
        275                 280                 285             


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
    290                 295                 300                 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
305                 310                 315                 320 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
                325                 330                 335     


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
            340                 345                 350         


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
        355                 360                 365             


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
    370                 375                 380                 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
385                 390                 395                 400 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
                405                 410                 415     


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
            420                 425                 430         


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg Ser Gln Asn Ile Ser 
        435                 440                 445             


Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
    450                 455                 460                 


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
465                 470                 475                 480 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
                485                 490                 495     


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
            500                 505                 510         


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
        515                 520                 525             


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
    530                 535                 540                 


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
545                 550                 555                 560 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
                565                 570                 575     


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
            580                 585                 590         


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
        595                 600                 605             


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg Ser Gln Asn Ile Ser 
    610                 615                 620                 


Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
625                 630                 635                 640 


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
                645                 650                 655     


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
            660                 665                 670         


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
        675                 680                 685             


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
    690                 695                 700                 


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
705                 710                 715                 720 


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
                725                 730                 735     


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
            740                 745                 750         


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
        755                 760                 765             


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
    770                 775                 780                 


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg Ser 
785                 790                 795     


<210>  26
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  26

Leu Pro Pro Arg Thr Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
1               5                   10                  15      


Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
            20                  25                  30          


Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro 
        35                  40                  45              


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
    50                  55                  60                  


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro 
65                  70                  75                  80  


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile 
                165                 170                 175     


Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser 
            180                 185                 190         


Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln 
        195                 200                 205             


Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala 
    210                 215                 220                 


Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Gln Leu Thr Val Leu Ser Arg Thr Pro Pro Met Ile Leu Arg 
            260                 265                 270         


Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
        275                 280                 285             


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
    290                 295                 300                 


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
305                 310                 315                 320 


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
                325                 330                 335     


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
            340                 345                 350         


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
        355                 360                 365             


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
    370                 375                 380                 


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
385                 390                 395                 400 


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
                405                 410                 415     


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
            420                 425                 430         


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
        435                 440                 445             


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg Ser Gln Asn Ile 
    450                 455                 460                 


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
465                 470                 475                 480 


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
                485                 490                 495     


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
            500                 505                 510         


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
        515                 520                 525             


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
    530                 535                 540                 


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
545                 550                 555                 560 


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
                565                 570                 575     


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
            580                 585                 590         


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
        595                 600                 605             


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
    610                 615                 620                 


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg Ser Gln Asn Ile 
625                 630                 635                 640 


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
                645                 650                 655     


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
            660                 665                 670         


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
        675                 680                 685             


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
    690                 695                 700                 


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
705                 710                 715                 720 


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
                725                 730                 735     


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
            740                 745                 750         


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
        755                 760                 765             


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
    770                 775                 780                 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
785                 790                 795                 800 


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Arg Ser 
                805                 810             


