                         SEQUENCE LISTING

<110>  Narasimhan, Chakravarthy Nachu
       De, Arnab
 
<120>  STABLE FORMULATIONS OF ANTI-TIGIT ANTIBODIES ALONE AND IN 
       COMBINATION WITH PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES 
       AND METHODS OF USE THEREOF

<130>  24453

<150>  62/500,278
<151>  2017-05-02

<160>  293   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  1

Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  2

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  3

Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Region

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  5
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  5

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  6

Asn Tyr Tyr Met Tyr 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  7

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  8

Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  11

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  12

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  13

Gln Gln Ser Ser Asn Trp Pro Arg Thr 
1               5                   


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  15

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  16

Asn Ser Gly Met His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  17

Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  18

Asn Asp Asp Tyr 
1               


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable region

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  20
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  21

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Phe Ser Tyr Leu His 
1               5                   10                  15  


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  22

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  23

Gln His Ser Trp Glu Leu Pro Leu Thr 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  24

Ser Tyr Tyr Leu Tyr 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  25

Gly Val Asn Pro Ser Asn Gly Gly Thr Asn Phe Ser Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  26

Arg Asp Ser Asn Tyr Asp Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  27
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain VR

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain VR

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain VR

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain VR

<400>  30

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  32
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  33
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  34
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  34

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  35

Ser Asp Tyr Trp Gly 
1               5   


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  36

Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  37

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  38

Lys Ala Ser Gln Ser Ile His Lys Asn Leu Ala 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  39

Tyr Ala Asn Ser Leu Gln Thr 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  40

Gln Gln Tyr Tyr Ser Gly Trp Thr 
1               5               


<210>  41
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental VH

<400>  41

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu His Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Ser Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  42
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental VL

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
            100                 105     


<210>  43
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy 

<400>  43

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  44
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  44

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  45
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  45

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  46
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  46

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  47
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  47

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  48
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  48

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  49
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  49

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  50
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  50

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  51
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  51

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  52
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  52

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  53
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  53

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  54
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  54

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ser Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  55
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  55

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  56
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  56

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  57
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  57

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ser Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  58
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  58

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ser Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu His Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  59
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  60
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  61
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  62
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  63
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  64
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  65
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy
<400>  65

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser 
    


<210>  66
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  66

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  67
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  67

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  68
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  68

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  69
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  69

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  70
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  70

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Pro Pro Gly Lys Lys Met Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  71
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  71

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Phe Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  72
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  72

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Lys Pro Pro Gly Lys Lys Met Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  73
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  73

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  74
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  74

Glu Val Gln Leu Gln Gln Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  75
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  75

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Pro Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Trp Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  76
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  77
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  78
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  79
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  79

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  80
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light
<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  81

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  82

Tyr Ile Ser Asn Ser Gly Ser Ala Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  83

Leu Ile Tyr Tyr Asp Tyr Gly Gly Ala Met Asn Phe 
1               5                   10          


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1
<400>  84

Lys Ala Ser Gln Gly Val Ser Thr Thr Val Ala 
1               5                   10      


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  85

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  86

Gln His Tyr Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  87
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  parental VH

<400>  87

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Asn Ser Gly Ser Ala Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Ile Tyr Tyr Asp Tyr Gly Gly Ala Met Asn Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  parental VL

<400>  88

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Gly Val Ser Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln His Tyr Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  89

Tyr Ala Ser Asn Leu Gln Thr 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  90

Tyr Ala Ser Ser Leu Gln Thr 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  91

Tyr Ala Ser Thr Leu Gln Thr 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  92

Tyr Ala Thr Thr Leu Gln Thr 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  93

Tyr Ala Ser Tyr Leu Gln Thr 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  94

Tyr Ala Asn Gln Leu Gln Thr 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  95

Tyr Ala Gly Ser Leu Gln Thr 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  96

Tyr Ala Ser Gln Leu Gln Thr 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  97

Tyr Ala Asp Ser Leu Gln Thr 
1               5           


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  98

Gln Gln Tyr Tyr Ser Gly Phe Thr 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  99

Gln Gln Tyr Tyr Ser Gly Tyr Thr 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  100

Gln Gln Tyr Tyr Ser Gly Ile Thr 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  101

Gln Gln Tyr Tyr Ser Gly Val Thr 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  102

Gln Gln Tyr Tyr Ser Gly Leu Thr 
1               5               


<210>  103
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  103

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Phe Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  104
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  104

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Tyr Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  105
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  105

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Ile Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  106
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  106

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Val Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  107
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 variant

<400>  107

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Leu Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  108

Ser Tyr Val Met His 
1               5   


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  109

Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  110

Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val 
1               5                   10  


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  111

Arg Ala Ser Glu His Ile Tyr Ser Tyr Leu Ser 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  112

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  113

Gln His His Phe Gly Ser Pro Leu Thr 
1               5                   


<210>  114
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  parental VH

<400>  114

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  parental VL

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105         


<210>  116
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  116

Tyr Ile Asp Pro Tyr Asn Arg Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  117
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  117

Tyr Ile Asp Pro Tyr Asn Leu Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  118

Tyr Ile Asp Pro Tyr Asn Lys Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  119

Tyr Ile Asp Pro Tyr Asn Phe Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  120

Tyr Ile Asp Pro Tyr Asn Ser Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  121
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  121

Tyr Ile Asp Pro Tyr Asn Tyr Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  122

Tyr Ile Asp Pro Tyr Asn Val Gly Ala Lys Tyr Asn Glu Lys Phe Gly 
1               5                   10                  15      


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  123

Tyr Ile Asp Pro Tyr Asn Asp Arg Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  124

Tyr Ile Asp Pro Tyr Asn Asp Asn Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  125

Tyr Ile Asp Pro Tyr Asn Asp Gln Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  126

Tyr Ile Asp Pro Tyr Asn Asp Glu Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  127

Tyr Ile Asp Pro Tyr Asn Asp Leu Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  128

Tyr Ile Asp Pro Tyr Asn Asp Lys Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  129

Tyr Ile Asp Pro Tyr Asn Asp Ser Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  130

Tyr Ile Asp Pro Tyr Asn Asp Tyr Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 variant

<400>  131

Tyr Ile Asp Pro Tyr Asn Asp Val Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant

<400>  132

Ala Ala Lys Thr Leu Ala Glu 
1               5           


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant

<400>  133

Tyr Ala Lys Thr Leu Ala Glu 
1               5           


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant 

<400>  134

Trp Ala Lys Thr Leu Ala Glu 
1               5           


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant

<400>  135

Ser Ala Lys Thr Leu Ala Glu 
1               5           


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant

<400>  136

Thr Ala Lys Thr Leu Ala Glu 
1               5           


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant 

<400>  137

Ile Ala Lys Thr Leu Ala Glu 
1               5           


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant 

<400>  138

Val Ala Lys Thr Leu Ala Glu 
1               5           


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant 

<400>  139

Asn Asn Lys Thr Leu Ala Glu 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant 

<400>  140

Asn Ile Lys Thr Leu Ala Glu 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant

<400>  141

Asn Leu Leu Thr Leu Ala Glu 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant

<400>  142

Asn Thr Lys Thr Leu Ala Glu 
1               5           


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 variant 

<400>  143

Asn Val Lys Thr Leu Ala Glu 
1               5           


<210>  144
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  144

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  145
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  146
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  146

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  147
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  147

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  148
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  148

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  149
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  149

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  151

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  152
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  152

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  153

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  154

Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  155
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 variant

<400>  155

Tyr Ile Asp Pro Tyr Asn Asp Gly Ala Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  156
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  156

Gln Val Gln Leu Met Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Pro Leu Thr Ser Tyr 
            20                  25                  30          


Thr Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Trp Ser Ser Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asn Ile Asn Arg Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Lys Ser Gly Trp Ala Phe Phe Asp Tyr Trp Gly Gln Gly Val Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  157
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Ile Ala Ser Gln Asn Ile Tyr Lys Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Leu Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Gly Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  158
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Leu Ala Pro Gln Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Glu Gly Ser Arg Thr His Tyr Gly Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ile Ile Ser Arg Asp Asn Pro Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Thr Gly Thr Leu Asp Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ile Val Ser Ser 
        115                 


<210>  159
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  159

Asn Ile Val Met Ala Gln Ser Pro Lys Ser Met Ser Ile Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Asn Cys Lys Ala Ser Gln Asn Val Asp Asn Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Gly Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Phe Tyr Tyr Cys Gln Arg Ile Tyr Asn Phe Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  160
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is W, F, Y, I, V or L

<400>  160

Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Xaa Glu Gly Tyr 
1               5                   10                  15      


Phe Asp Phe 
            


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is N, S, T, G or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, N, S, T, Y or Q

<400>  161

Tyr Ala Xaa Xaa Leu Gln Thr 
1               5           


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is W, F, Y, I, V, OR L

<400>  162

Gln Gln Tyr Tyr Ser Gly Xaa Thr 
1               5               


<210>  163
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH parental


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is P or A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is S or P

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is Q, E, or G

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is S, T, or A

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is S, G, or Y

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  X is I or V
<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is K or Q

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is F or P

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is N or K

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  X is K or G

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is M or L

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is M or I

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is R or V

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is F or S

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is H or S

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is D or A

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is T or V

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  X is S or Y

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is W, F, Y, I, V, or L

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X is P or Q

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  X is M, V, L, A, R, N, P, Q, E, G, I, H, K, F, S, T, W or Y

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  X is V, T, or L

<400>  163

Glu Val Gln Leu Gln Xaa Ser Gly Xaa Gly Leu Xaa Lys Pro Xaa Xaa 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Xaa Val Xaa Gly Xaa Ser Ile Xaa Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Xaa Arg Xaa Xaa Pro Gly Xaa Xaa Xaa Glu Trp Xaa 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Xaa Xaa Ile Xaa Xaa Asp Thr Ser Lys Asn Gln Phe Xaa Leu 
65                  70                  75                  80  


Xaa Leu Xaa Ser Val Thr Xaa Xaa Asp Thr Ala Xaa Tyr Xaa Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Xaa Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Xaa Gly Thr Xaa Xaa Thr Val Ser Ser 
        115                 120                 125         


<210>  164
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is P or A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is S or P

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is E or G

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is T, A, or S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is G, S, or Y

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is P or F

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  X is G or K

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is L or M

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is I or M

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is V or R

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is S or H

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  X is A or D

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is W, F, Y, I, V, or L

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  X is M, V, L, A, R, N, P, Q, E, G, I, H, K, F, S, T, W, or Y
<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  X is V, T, or L

<400>  164

Glu Val Gln Leu Gln Xaa Ser Gly Xaa Gly Leu Xaa Lys Pro Xaa Xaa 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Xaa Val Xaa Gly Xaa Ser Ile Xaa Ser Asp 
            20                  25                  30          


Tyr Trp Gly Trp Xaa Arg Xaa Xaa Pro Gly Lys Xaa Xaa Glu Trp Xaa 
        35                  40                  45              


Gly Phe Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Xaa Ser Val Thr Ala Xaa Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Pro Ser Phe Ile Thr Leu Ala Ser Leu Ser Thr Xaa Glu Gly 
            100                 105                 110         


Tyr Phe Asp Phe Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser Ser 
        115                 120                 125         


<210>  165
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light parental consensus


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is L or S

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is L or I

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is N or T

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is L or P

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is E or K

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  X is N, S, T, G, or D

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is S, N, T, Y, or Q

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X is I or V
<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  X is G or S

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is V or F

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is F or Y

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X is W, F, Y, I, V, or L

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  X is L or I

<400>  165

Asp Ile Gln Met Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Xaa Xaa Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Xaa Gly Xaa Xaa Pro Lys Xaa Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Xaa Xaa Leu Gln Thr Gly Xaa Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Xaa Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Ala Thr Tyr Xaa Cys Gln Gln Tyr Tyr Ser Gly Xaa Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Xaa Lys 
            100                 105     


<210>  166
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light consensus


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X is A or V

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  X is L or F

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X is N, S, T, G, or D

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  X is S, N, T, Y, or Q

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is F or V

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X is W, F, Y, I, V, or L

<400>  166

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Ile His Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Xaa Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Xaa Xaa Leu Gln Thr Gly Xaa Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Gly Xaa Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  167
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 Consensus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is D, R, L, K, F, S, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is G, R, N, Q, E, L, K, S, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is N, A, or S

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is K or Q

<400>  167

Tyr Ile Asp Pro Tyr Asn Xaa Xaa Ala Lys Tyr Xaa Xaa Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  X is N, A, V, W, S, T, R, H, G, I, or V

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is A, N, I, L, T, or V

<400>  168

Xaa Xaa Lys Thr Leu Ala Glu 
1               5           


<210>  169
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH parental


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Q or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is P or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is V or L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is V or K

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is M or V

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is K or A

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  X is G or R

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is D, R, L, K, F, S, Y or V

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is G, R, N, Q, E, L, K, S, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is N, A, or S

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  X is K or Q

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  X is R or K

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is S or R

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is K or T

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is S, I, A, or T

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is R or S

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is T or R

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  X is D or E

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X is W, A, D, E, F, G, I, K, N, Q, R, S, T, V, or Y

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  X is A or Q

<400>  169

Glu Val Gln Leu Xaa Gln Ser Gly Xaa Glu Xaa Xaa Lys Pro Gly Xaa 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Xaa Gln Xaa Pro Gly Gln Xaa Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Xaa Xaa Ala Lys Tyr Xaa Xaa Lys Phe 
    50                  55                  60                  


Xaa Gly Xaa Xaa Thr Leu Thr Xaa Asp Xaa Ser Xaa Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Xaa Leu Xaa Ser Xaa Asp Xaa Xaa Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Xaa Tyr Phe Asp Val Trp Gly Xaa Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  170
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy consensus


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  X is R or G

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is D, R, L, K, F, S, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  X is G, R, N, Q, E, L, K, S, Y or V

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  X is N, A, or S

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  X is K or Q

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is R or S

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is T or K

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is A, T, or I

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is S or R

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  X is E or D

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X is W, A, D, E, F, G, I, K, N, Q, R, S, T, V, or Y

<400>  170

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Xaa 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Xaa Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Xaa Xaa Ala Lys Tyr Xaa Xaa Lys Phe 
    50                  55                  60                  


Xaa Gly Arg Val Thr Leu Thr Xaa Asp Xaa Ser Xaa Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Xaa Leu Arg Ser Xaa Asp Thr Xaa Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Tyr Gly Xaa Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light consensus

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is E or D

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is T or R

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is Q or P

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is S, A, or V

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  X is N, A, Y, W, S, T, I, or V

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is A, N, I, L, T, or V

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is Q or D

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is K or T

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is F or V

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is G or A

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X is A or Q

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X is T or R

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  X is L or I

<400>  171

Asp Ile Gln Met Thr Gln Ser Pro Xaa Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Xaa Xaa Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Xaa Gly Lys Xaa Pro Xaa Leu Leu Xaa 
        35                  40                  45              


Tyr Xaa Xaa Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Xaa Leu Xaa Ile Xaa Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Xaa Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Xaa Leu Glu Xaa Lys 
            100                 105         


<210>  172
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light consensus


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is A or V

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  X is N, A, Y, W, S, T, I, or V

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is A, N, I, L, T, or V

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is D or Q
<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  X is F or V

<400>  172

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu His Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Xaa Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln His His Phe Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is W, A, D, E, F, G, I, K, N, Q, R, S, T, V, or Y

<400>  173

Gly Gly Pro Tyr Gly Xaa Tyr Phe Asp Val 
1               5                   10  


<210>  174
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  174

Gly Gly Pro Tyr Gly Ala Tyr Phe Asp Val 
1               5                   10  


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  175

Gly Gly Pro Tyr Gly Asp Tyr Phe Asp Val 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  176

Gly Gly Pro Tyr Gly Glu Tyr Phe Asp Val 
1               5                   10  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  177

Gly Gly Pro Tyr Gly Phe Tyr Phe Asp Val 
1               5                   10  


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  178

Gly Gly Pro Tyr Gly Gly Tyr Phe Asp Val 
1               5                   10  


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  179

Gly Gly Pro Tyr Gly Ile Tyr Phe Asp Val 
1               5                   10  


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  180

Gly Gly Pro Tyr Gly Lys Tyr Phe Asp Val 
1               5                   10  


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  181

Gly Gly Pro Tyr Gly Asn Tyr Phe Asp Val 
1               5                   10  


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  182

Gly Gly Pro Tyr Gly Gln Tyr Phe Asp Val 
1               5                   10  


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  183

Gly Gly Pro Tyr Gly Arg Tyr Phe Asp Val 
1               5                   10  


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  184

Gly Gly Pro Tyr Gly Ser Tyr Phe Asp Val 
1               5                   10  


<210>  185
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  185

Gly Gly Pro Tyr Gly Thr Tyr Phe Asp Val 
1               5                   10  


<210>  186
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  186

Gly Gly Pro Tyr Gly Val Tyr Phe Asp Val Ser Glu Gln Ile Asp 
1               5                   10                  15  


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  187

Gly Gly Pro Tyr Gly Tyr Tyr Phe Asp Val 
1               5                   10  


<210>  188
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  188

Gly Ala Trp Met Asp 
1               5   


<210>  189
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  189

Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  190

Ala Leu Tyr Asp Gly Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  191
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  191

Ser Ala Ser Ser Ser Val Ser Ser Gly Tyr Leu Tyr 
1               5                   10          


<210>  192
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  192

Gly Thr Ser Thr Leu Ala Ser 
1               5           


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  193

His Gln Trp Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  194
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  194

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Ser Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  195
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  195

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Asn Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105             


<210>  196
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy consensus


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is W, A, R, N, D, Q, E, G, H, I, L, K, F, P, S, T, Y or V

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is M, V, L, I, G, A, S, T

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is D, A, R, N, Q, E, G, H, I, L, K, F, S, T, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  X is M or L

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is N or S

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  X is S or N

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X is D, A, R, N, Q, E, G, H, I, L, K, F, P, S, T, W, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  X is G, A, R, N, D, Q, E, H, I, L, K, F, P, S, T, W, Y or V

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Xaa Xaa Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Ser Lys Xaa Xaa 
65                  70                  75                  80  


Val Tyr Leu Gln Xaa Xaa Xaa Leu Arg Ala Glu Asp Xaa Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Xaa Xaa Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  197
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  197

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  198
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  199
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  200
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light consensus


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is W, A, R, N, D, Q, E, G, H, I, L, K, F, P, S, T, Y, or V

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X is V or I

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X is L, V, or I

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is F, V, L, I, or T

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  X is W, A, R, N, D, Q, E, G, H, I, L, K, F, P, S, T, Y or V

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X is I or L

<400>  200

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Xaa Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Xaa Leu Xaa 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Xaa Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Xaa Glu 
65                  70                  75                  80  


Pro Glu Asp Xaa Ala Val Tyr Tyr Cys His Gln Xaa Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Xaa Lys 
            100                 105             


<210>  201
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  201

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  202
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  202

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  203
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  203

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  204

Glu Phe Thr Met His 
1               5   


<210>  205
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  205

Gly Leu Lys Pro Asp Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  206

Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr 
1               5                   10  


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  207

Lys Ala Ser Gln Asp Val Lys Thr Ala Val Ala 
1               5                   10      


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  208

Ser Ala Ser Tyr Arg Asn Thr 
1               5           


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  209

Gln Gln His Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  210
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy parental

<400>  210

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ala Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  211
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light parental

<400>  211

Asp Ile Val Leu Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Lys Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Asp Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  212
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy consensus


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  X is T or V

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  X is M, V, L, I, G, A, S, or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is N, A, R, D, Q, E, G, H, I, L, K, F, P, S, T, W, Y, or Y

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is G, A, R, N, D, W, E, H, I, L, K, F, P, S, T, W, Y or V

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  X is K, T, D, or S

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  X is N or S

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  X is M, V, L, I, G, A, S, or T

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  X is T or S

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  X is D, A, R, N, Q, E, G, H, I, L, K, F, P, S, T, W, Y or V

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  X is A, R, N, D, Q, E, G, H, I, L, K, F, P, S, T, W, Y, V, or M
<220>

<400>  212

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Xaa Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Xaa His Trp Val Xaa Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Xaa Xaa Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Xaa Ser Thr Xaa Thr Ala Tyr 
65                  70                  75                  80  


Xaa Glu Leu Ser Ser Leu Arg Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Xaa Xaa Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  213
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  213

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  214
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  214

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  215
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  215

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  216
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light consensus


<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  X is N, Q, D, or E

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  X is T, S, or A

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  X is D or S

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  X is F or L

<400>  216

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Lys Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Xaa Xaa Gly Val Pro Xaa Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Xaa Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  217
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  217

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Lys Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  218
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  218

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Lys Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Asn Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  219
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  219

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Lys Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Asn Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  220

Ala Leu Tyr Glu Gly Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  221
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  221

Ala Leu Tyr Asp Ala Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  222
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  222

Ala Leu Tyr Asp Ser Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  223
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Glu Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  224
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  224

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Ala Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  225
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  225

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  226
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  226

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Glu Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  227
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  227

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Ala Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  228
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  228

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  229
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  229

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Glu Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  230
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Ala Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  231
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  231

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Thr Lys Val Asn Asn His Ala Thr Asn Tyr Gly Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Arg Gly Ala Leu Tyr Asp Ser Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  232

His Gln Ala Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  233

His Gln Asp Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  234
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  234

His Gln Glu Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  235

His Gln Phe Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  236

His Gln Gly Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  237

His Gln His Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  238
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  238

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ala Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  239
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  239

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Asp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  240
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  240

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Glu Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  241
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  241

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Phe Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  242
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  242

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Gly Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  243
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  243

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln His Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  244
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  244

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ala Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  245
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  245

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Asp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  246
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  246

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Glu Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  247
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  247

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Phe Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  248
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  248

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Gly Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  249
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  249

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln His Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  250
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  250

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ala Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  251
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  251

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Asp Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  252
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  252

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Glu Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  253
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  253

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Phe Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  254
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  254

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Gly Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  255
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light

<400>  255

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln His Ser Ser Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  256
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  256

Gly Leu Lys Pro Asp Gln Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  257
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  257

Gly Leu Lys Pro Asp Asp Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  258
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  258

Gly Leu Lys Pro Asp Asn Ala Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  259
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  259

Gly Leu Lys Pro Asp Thr Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  260
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  260

Gly Leu Lys Pro Asp Ser Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  261
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  261

Gly Leu Lys Pro Asp Gly Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  262
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  262

Gly Leu Lys Pro Asp Asn Ser Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  263
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  263

Gly Leu Lys Pro Asp Asn Thr Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  264
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  264

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Gln Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  265
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  265

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asp Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  266
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  266

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Ala Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  267
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  267

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Thr Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  268
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  268

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Ser Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  269
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  269

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Gly Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  270
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  270

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Ser Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  271
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  271

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Thr Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  272
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  272

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Gln Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  273
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  273

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asp Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  274
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  274

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Ala Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  275
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  275

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Thr Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  276
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  276

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Ser Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  277
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  277

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Gly Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  278
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  278

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Ser Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  279
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  279

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Thr Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  280
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  280

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Gln Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  281
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  281

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asp Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  282
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  282

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Ala Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  283
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  283

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Thr Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  284
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  284

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Ser Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  285
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  285

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Gly Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  286
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  286

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Ser Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  287
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy

<400>  287

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Leu Lys Pro Asp Asn Thr Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Arg Tyr Asp Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  288
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIGIT epitope 24-41

<400>  288

Ser Ser Thr Thr Ala Gln Val Asn Trp Glu Gln Gln Asp Gln Leu 
1               5                   10                  15  


<210>  289
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIGIT epitope 85-93

<400>  289

Ile Tyr His Thr Tyr Pro Asp Gly Thr 
1               5                   


<210>  290
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTIGIT epitope 96-100

<400>  290

Gly Arg Ile Phe Leu 
1               5   


<210>  291
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant domain IgG1

<400>  291

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  292
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant domain IgG4 S228P
 
<400>  292

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
1               5                   10                  15      


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
65                  70                  75                  80  


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
                85                  90                  95      


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
            100                 105                 110         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        195                 200                 205             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Leu Gly Lys 
                325 


<210>  293
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant domain

<400>  293

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


