                               SEQUENCE LISTING

<110> THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND 
      AGRICULTURAL AND MECHANICAL COLLEGE
 
<120> COMPOSITIONS AND METHODS FOR TREATING OCULAR PATHOLOGIES

<130> 2932719-007-WO2

<140> PCT/US2018/030448
<141> 2018-05-01

<150> 62/492,841
<151> 2017-05-01

<160> 3     

<170> PatentIn version 3.5

<210> 1
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Leu Ser Tyr Arg Val Ser Glu Leu Gln Ser Thr Ile Pro Glu 
1               5                   10                  15      


His Ile Leu Gln Ser Thr Phe Val His Val Ile Ser Ser Asn Trp Ser 
            20                  25                  30          


Gly Leu Gln Thr Glu Ser Ile Pro Glu Glu Met Lys Gln Ile Val Glu 
        35                  40                  45              


Glu Gln Gly Asn Lys Leu His Trp Ala Ala Leu Leu Ile Leu Met Val 
    50                  55                  60                  


Ile Ile Pro Thr Ile Gly Gly Asn Thr Leu Val Ile Leu Ala Val Ser 
65                  70                  75                  80  


Leu Glu Lys Lys Leu Gln Tyr Ala Thr Asn Tyr Phe Leu Met Ser Leu 
                85                  90                  95      


Ala Val Ala Asp Leu Leu Val Gly Leu Phe Val Met Pro Ile Ala Leu 
            100                 105                 110         


Leu Thr Ile Met Phe Glu Ala Met Trp Pro Leu Pro Leu Val Leu Cys 
        115                 120                 125             


Pro Ala Trp Leu Phe Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met 
    130                 135                 140                 


His Leu Cys Ala Ile Ser Val Asp Arg Tyr Ile Ala Ile Lys Lys Pro 
145                 150                 155                 160 


Ile Gln Ala Asn Gln Tyr Asn Ser Arg Ala Thr Ala Phe Ile Lys Ile 
                165                 170                 175     


Thr Val Val Trp Leu Ile Ser Ile Gly Ile Ala Ile Pro Val Pro Ile 
            180                 185                 190         


Lys Gly Ile Glu Thr Asp Val Asp Asn Pro Asn Asn Ile Thr Cys Val 
        195                 200                 205             


Leu Thr Lys Glu Arg Phe Gly Asp Phe Met Leu Phe Gly Ser Leu Ala 
    210                 215                 220                 


Ala Phe Phe Thr Pro Leu Ala Ile Met Ile Val Thr Tyr Phe Leu Thr 
225                 230                 235                 240 


Ile His Ala Leu Gln Lys Lys Ala Tyr Leu Val Lys Asn Lys Pro Pro 
                245                 250                 255     


Gln Arg Leu Thr Trp Leu Thr Val Ser Thr Val Phe Gln Arg Asp Glu 
            260                 265                 270         


Thr Pro Cys Ser Ser Pro Glu Lys Val Ala Met Leu Asp Gly Ser Arg 
        275                 280                 285             


Lys Asp Lys Ala Leu Pro Asn Ser Gly Asp Glu Thr Leu Met Arg Arg 
    290                 295                 300                 


Thr Ser Thr Ile Gly Lys Lys Ser Val Gln Thr Ile Ser Asn Glu Gln 
305                 310                 315                 320 


Arg Ala Ser Lys Val Leu Gly Ile Val Phe Phe Leu Phe Leu Leu Met 
                325                 330                 335     


Trp Cys Pro Phe Phe Ile Thr Asn Ile Thr Leu Val Leu Cys Asp Ser 
            340                 345                 350         


Cys Asn Gln Thr Thr Leu Gln Met Leu Leu Glu Ile Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Val Ser Ser Gly Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Phe Arg Asp Ala Phe Gly Arg Tyr Ile Thr Cys Asn Tyr Arg 
385                 390                 395                 400 


Ala Thr Lys Ser Val Lys Thr Leu Arg Lys Arg Ser Ser Lys Ile Tyr 
                405                 410                 415     


Phe Arg Asn Pro Met Ala Glu Asn Ser Lys Phe Phe Lys Lys His Gly 
            420                 425                 430         


Ile Arg Asn Gly Ile Asn Pro Ala Met Tyr Gln Ser Pro Met Arg Leu 
        435                 440                 445             


Arg Ser Ser Thr Ile Gln Ser Ser Ser Ile Ile Leu Leu Asp Thr Leu 
    450                 455                 460                 


Leu Leu Thr Glu Asn Glu Gly Asp Lys Thr Glu Glu Gln Val Ser Tyr 
465                 470                 475                 480 


Val 
    


<210> 2
<211> 471
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Ile Leu Cys Glu Glu Asn Thr Ser Leu Ser Ser Thr Thr Asn 
1               5                   10                  15      


Ser Leu Met Gln Leu Asn Asp Asp Thr Arg Leu Tyr Ser Asn Asp Phe 
            20                  25                  30          


Asn Ser Gly Glu Ala Asn Thr Ser Asp Ala Phe Asn Trp Thr Val Asp 
        35                  40                  45              


Ser Glu Asn Arg Thr Asn Leu Ser Cys Glu Gly Cys Leu Ser Pro Ser 
    50                  55                  60                  


Cys Leu Ser Leu Leu His Leu Gln Glu Lys Asn Trp Ser Ala Leu Leu 
65                  70                  75                  80  


Thr Ala Val Val Ile Ile Leu Thr Ile Ala Gly Asn Ile Leu Val Ile 
                85                  90                  95      


Met Ala Val Ser Leu Glu Lys Lys Leu Gln Asn Ala Thr Asn Tyr Phe 
            100                 105                 110         


Leu Met Ser Leu Ala Ile Ala Asp Met Leu Leu Gly Phe Leu Val Met 
        115                 120                 125             


Pro Val Ser Met Leu Thr Ile Leu Tyr Gly Tyr Arg Trp Pro Leu Pro 
    130                 135                 140                 


Ser Lys Leu Cys Ala Val Trp Ile Tyr Leu Asp Val Leu Phe Ser Thr 
145                 150                 155                 160 


Ala Ser Ile Met His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala 
                165                 170                 175     


Ile Gln Asn Pro Ile His His Ser Arg Phe Asn Ser Arg Thr Lys Ala 
            180                 185                 190         


Phe Leu Lys Ile Ile Ala Val Trp Thr Ile Ser Val Gly Ile Ser Met 
        195                 200                 205             


Pro Ile Pro Val Phe Gly Leu Gln Asp Asp Ser Lys Val Phe Lys Glu 
    210                 215                 220                 


Gly Ser Cys Leu Leu Ala Asp Asp Asn Phe Val Leu Ile Gly Ser Phe 
225                 230                 235                 240 


Val Ser Phe Phe Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Phe Leu 
                245                 250                 255     


Thr Ile Lys Ser Leu Gln Lys Glu Ala Thr Leu Cys Val Ser Asp Leu 
            260                 265                 270         


Gly Thr Arg Ala Lys Leu Ala Ser Phe Ser Phe Leu Pro Gln Ser Ser 
        275                 280                 285             


Leu Ser Ser Glu Lys Leu Phe Gln Arg Ser Ile His Arg Glu Pro Gly 
    290                 295                 300                 


Ser Tyr Thr Gly Arg Arg Thr Met Gln Ser Ile Ser Asn Glu Gln Lys 
305                 310                 315                 320 


Ala Cys Lys Val Leu Gly Ile Val Phe Phe Leu Phe Val Val Met Trp 
                325                 330                 335     


Cys Pro Phe Phe Ile Thr Asn Ile Met Ala Val Ile Cys Lys Glu Ser 
            340                 345                 350         


Cys Asn Glu Asp Val Ile Gly Ala Leu Leu Asn Val Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Leu Ser Ser Ala Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Tyr Arg Ser Ala Phe Ser Arg Tyr Ile Gln Cys Gln Tyr Lys 
385                 390                 395                 400 


Glu Asn Lys Lys Pro Leu Gln Leu Ile Leu Val Asn Thr Ile Pro Ala 
                405                 410                 415     


Leu Ala Tyr Lys Ser Ser Gln Leu Gln Met Gly Gln Lys Lys Asn Ser 
            420                 425                 430         


Lys Gln Asp Ala Lys Thr Thr Asp Asn Asp Cys Ser Met Val Ala Leu 
        435                 440                 445             


Gly Lys Gln His Ser Glu Glu Ala Ser Lys Asp Asn Ser Asp Gly Val 
    450                 455                 460                 


Asn Glu Lys Val Ser Cys Val 
465                 470     


<210> 3
<211> 458
<212> PRT
<213> Homo sapiens

<400> 3
Met Val Asn Leu Arg Asn Ala Val His Ser Phe Leu Val His Leu Ile 
1               5                   10                  15      


Gly Leu Leu Val Trp Gln Cys Asp Ile Ser Val Ser Pro Val Ala Ala 
            20                  25                  30          


Ile Val Thr Asp Ile Phe Asn Thr Ser Asp Gly Gly Arg Phe Lys Phe 
        35                  40                  45              


Pro Asp Gly Val Gln Asn Trp Pro Ala Leu Ser Ile Val Ile Ile Ile 
    50                  55                  60                  


Ile Met Thr Ile Gly Gly Asn Ile Leu Val Ile Met Ala Val Ser Met 
65                  70                  75                  80  


Glu Lys Lys Leu His Asn Ala Thr Asn Tyr Phe Leu Met Ser Leu Ala 
                85                  90                  95      


Ile Ala Asp Met Leu Val Gly Leu Leu Val Met Pro Leu Ser Leu Leu 
            100                 105                 110         


Ala Ile Leu Tyr Asp Tyr Val Trp Pro Leu Pro Arg Tyr Leu Cys Pro 
        115                 120                 125             


Val Trp Ile Ser Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met His 
    130                 135                 140                 


Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala Ile Arg Asn Pro Ile 
145                 150                 155                 160 


Glu His Ser Arg Phe Asn Ser Arg Thr Lys Ala Ile Met Lys Ile Ala 
                165                 170                 175     


Ile Val Trp Ala Ile Ser Ile Gly Val Ser Val Pro Ile Pro Val Ile 
            180                 185                 190         


Gly Leu Arg Asp Glu Glu Lys Val Phe Val Asn Asn Thr Thr Cys Val 
        195                 200                 205             


Leu Asn Asp Pro Asn Phe Val Leu Ile Gly Ser Phe Val Ala Phe Phe 
    210                 215                 220                 


Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Cys Leu Thr Ile Tyr Val 
225                 230                 235                 240 


Leu Arg Arg Gln Ala Leu Met Leu Leu His Gly His Thr Glu Glu Pro 
                245                 250                 255     


Pro Gly Leu Ser Leu Asp Phe Leu Lys Cys Cys Lys Arg Asn Thr Ala 
            260                 265                 270         


Glu Glu Glu Asn Ser Ala Asn Pro Asn Gln Asp Gln Asn Ala Arg Arg 
        275                 280                 285             


Arg Lys Lys Lys Glu Arg Arg Pro Arg Gly Thr Met Gln Ala Ile Asn 
    290                 295                 300                 


Asn Glu Arg Lys Ala Ser Lys Val Leu Gly Ile Val Phe Phe Val Phe 
305                 310                 315                 320 


Leu Ile Met Trp Cys Pro Phe Phe Ile Thr Asn Ile Leu Ser Val Leu 
                325                 330                 335     


Cys Glu Lys Ser Cys Asn Gln Lys Leu Met Glu Lys Leu Leu Asn Val 
            340                 345                 350         


Phe Val Trp Ile Gly Tyr Val Cys Ser Gly Ile Asn Pro Leu Val Tyr 
        355                 360                 365             


Thr Leu Phe Asn Lys Ile Tyr Arg Arg Ala Phe Ser Asn Tyr Leu Arg 
    370                 375                 380                 


Cys Asn Tyr Lys Val Glu Lys Lys Pro Pro Val Arg Gln Ile Pro Arg 
385                 390                 395                 400 


Val Ala Ala Thr Ala Leu Ser Gly Arg Glu Leu Asn Val Asn Ile Tyr 
                405                 410                 415     


Arg His Thr Asn Glu Pro Val Ile Glu Lys Ala Ser Asp Asn Glu Pro 
            420                 425                 430         


Gly Ile Glu Met Gln Val Glu Asn Leu Glu Leu Pro Val Asn Pro Ser 
        435                 440                 445             


Ser Val Val Ser Glu Arg Ile Ser Ser Val 
    450                 455             


