                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Luk, Kelvin
       Lee, Virginia
       Trojanowski, John
       Brunden, Kurt
       Covell, Dustin
 
<120>  Monoclonal antibodies to alpha-synuclein fibrils

<130>  046483-7153WO1(01656)

<150>  US 62/492,663
<151>  2017-05-01

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Ser Ser Val Ser Tyr 
1               5   


<210>  2
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Thr Ser 
1           


<210>  3
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Gln Trp Arg Ser Tyr Pro Pro Thr 
1               5                   


<210>  4
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  5
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  5
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaagctgg cttctggcgt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agaagttacc cacccacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  6
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Ile Trp Ser Gly Gly Ser Thr 
1               5           


<210>  8
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  8

Ala Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr 
1               5                   10                  


<210>  9
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Gln Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Leu Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  10
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  10
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag ccagtccctg       60

acctgcacag tctctggttt ctcattaact agttatggcg tacactgggt tcgccagcct      120

ctaggaaagg gtctggagtg gctgggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagact gagcatcagg aaggacaact ccaagagcca agtcttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  11
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  11

Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  12
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  12

Trp Ala Ser 
1           


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

His Gln Tyr Leu Ser Leu Phe Thr 
1               5               


<210>  14
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  14

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Met Leu Ile Tyr Trp Ala Ser Phe Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Leu Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  15
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact       60

atgagctgta agtccagtca aagtgtttta tacagttcaa atcagaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaaatgctga tctactgggc atcctttagg      180

gaatctggtg tccctgatcg cttcacaggc agtggatctg ggacagattt tactcttacc      240

atcagcagtg tacaagctga agacctggca gtttattact gtcatcaata cctctcctta      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

Gly Tyr Thr Phe Thr Thr Phe Tyr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  17

Ile Tyr Pro Val Asn Val Lys Ile 
1               5               


<210>  18
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  18

Val Arg Gly Gly Arg Gly Leu Asp Tyr 
1               5                   


<210>  19
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Tyr Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Val Asn Val Lys Ile Lys Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Gly Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  20
caggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgcggata       60

tcctgcaagg cttctggcta caccttcaca accttctatt tacactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg taaatgttaa aattaagtac      180

agtgagaggt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctcg gcagcctgac ctctgaggac tctgcggtct atttctgtgt aagagggggg      300

aggggacttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  21
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  21

Ser Ser Val Thr Tyr 
1               5   


<210>  22
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Thr Ser 
1           


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  24
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105     


<210>  25
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  25
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccacgtt cggagggggg      300

accaagctgg aaataaga                                                    318


<210>  26
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  26

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  28

Val Arg Gly Gly Leu Ser Pro Phe Asp Tyr 
1               5                   10  


<210>  29
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asp Asn Leu Lys Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Gly Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  30
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  30
gaggtacacc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat acctacgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaaata aaagtaataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctttctgc aaatggacaa cttgaaaact gaggacacag ccatatatta ctgtgtgaga      300

ggggggttat ctccctttga ctactggggc caaggcacca cactcacagt ctcctca         357


<210>  31
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


