                         SEQUENCE LISTING

<110>  The Scripps Research Institute
       Saphire, Erica
       Hastie, Kathryn
 
<120>  COMPOSITIONS AND METHODS RELATED TO ARENAVIRUS IMMUNOGENS

<130>  1790.1PC

<140>  PCT/US2018/028275
<141>  2018-04-19

<150>  US 62/500,095
<151>  2017-05-02

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  424
<212>  PRT
<213>  Lassa virus

<400>  1

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Glu Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly 
            420                 


<210>  2
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Cys Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Pro Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Cys Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly 
            420                 


<210>  3
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Cys Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Pro Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Cys Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly 
            420                 


<210>  4
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Cys Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Pro Cys Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly 
            420                 


<210>  5
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Cys Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Pro Ala Cys Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly 
            420                 


<210>  6
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Arg Arg Leu Leu 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Arg Arg Arg Arg 
1               


<210>  8
<211>  430
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn Tyr Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Ile Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Cys Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Pro Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Cys Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly 
            420                 425                 430 


<210>  9
<211>  386
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Met Gly Gln Ile Val Ala Val Phe Gln Ala Ile Pro Glu Ile Leu Asn 
1               5                   10                  15      


Glu Ala Ile Asn Ile Val Ile Ile Val Ile Ile Met Phe Thr Leu Ile 
            20                  25                  30          


Lys Gly Val Phe Asn Leu Tyr Lys Ser Gly Leu Phe Gln Leu Val Ile 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Lys Arg Cys Asp Ser Ser Leu Leu Ser Gly 
    50                  55                  60                  


Phe Asn Leu Glu Thr Val His Phe Asn Met Ser Leu Leu Ser Ser Ile 
65                  70                  75                  80  


Pro Met Val Ser Glu Gln Gln His Cys Ile Gln His Asn His Ser Ser 
                85                  90                  95      


Ile Thr Phe Ser Leu Leu Thr Asn Lys Ser Asp Leu Glu Lys Cys Asn 
            100                 105                 110         


Phe Thr Arg Leu Gln Ala Val Asp Arg Val Ile Phe Asp Leu Phe Arg 
        115                 120                 125             


Glu Phe His His Arg Val Gly Asp Phe Pro Val Thr Ser Asp Leu Lys 
    130                 135                 140                 


Cys Ser His Asn Thr Ser Tyr Arg Val Ile Glu Tyr Glu Val Thr Lys 
145                 150                 155                 160 


Glu Ser Leu Pro Arg Leu Gln Glu Ala Val Ser Thr Leu Phe Pro Asp 
                165                 170                 175     


Leu His Leu Ser Glu Asp Arg Phe Leu Gln Ile Gln Ala His Asp Asp 
            180                 185                 190         


Lys Asn Cys Thr Gly Leu His Pro Leu Asn Tyr Leu Cys Leu Leu Lys 
        195                 200                 205             


Glu Asn Ser Glu Thr His Tyr Lys Val Arg Arg Arg Arg Lys Leu Phe 
    210                 215                 220                 


Gln Trp Ser Leu Ser Asp Glu Thr Gly Ser Pro Leu Pro Gly Gly His 
225                 230                 235                 240 


Cys Leu Glu Arg Trp Leu Ile Phe Ala Ser Asp Ile Lys Cys Phe Asp 
                245                 250                 255     


Asn Ala Ala Ile Ala Lys Cys Asn Lys Glu His Asp Glu Glu Phe Cys 
            260                 265                 270         


Asp Met Leu Arg Leu Phe Asp Tyr Asn Lys Ala Ser Ile Ala Lys Leu 
        275                 280                 285             


Pro Gly Glu Ala Ser Ser Ser Ile Asn Leu Leu Ser Gly Arg Ile Asn 
    290                 295                 300                 


Ala Ile Ile Ser Asp Thr Leu Cys Met Arg Ser Ser Leu Lys Arg Leu 
305                 310                 315                 320 


Met Gly Ile Pro Tyr Cys Asn Tyr Thr Lys Phe Trp Tyr Leu Asn His 
                325                 330                 335     


Thr Lys Leu Gly Ile His Ser Leu Pro Arg Cys Trp Leu Val Ser Asn 
            340                 345                 350         


Gly Ser Tyr Leu Asn Glu Thr Lys Phe Thr His Asp Met Glu Asp Glu 
        355                 360                 365             


Ala Asp Lys Leu Leu Thr Glu Met Leu Lys Lys Glu Tyr Val Arg Arg 
    370                 375                 380                 


Gln Glu 
385     


<210>  10
<211>  427
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Met Gly Gln Leu Ile Ser Phe Phe Gln Glu Ile Pro Val Phe Leu Gln 
1               5                   10                  15      


Glu Ala Leu Asn Ile Ala Leu Val Ala Val Ser Leu Ile Ala Val Ile 
            20                  25                  30          


Lys Gly Ile Ile Asn Leu Tyr Lys Ser Gly Leu Phe Gln Phe Ile Phe 
        35                  40                  45              


Phe Leu Leu Leu Ala Gly Arg Ser Cys Ser Asp Gly Thr Phe Lys Ile 
    50                  55                  60                  


Gly Leu His Thr Glu Phe Gln Ser Val Thr Leu Thr Met Gln Arg Leu 
65                  70                  75                  80  


Leu Ala Asn His Ser Asn Glu Leu Pro Ser Leu Cys Met Leu Asn Asn 
                85                  90                  95      


Ser Phe Tyr Tyr Met Arg Gly Gly Val Asn Thr Phe Leu Ile Arg Val 
            100                 105                 110         


Ser Asp Ile Ser Val Leu Met Lys Glu Tyr Asp Val Ser Ile Tyr Glu 
        115                 120                 125             


Pro Glu Asp Leu Gly Asn Cys Leu Asn Lys Ser Asp Ser Ser Trp Ala 
    130                 135                 140                 


Ile His Trp Phe Ser Asn Ala Leu Gly His Asp Trp Leu Met Asp Pro 
145                 150                 155                 160 


Pro Met Leu Cys Arg Asn Lys Thr Lys Lys Glu Gly Ser Asn Ile Gln 
                165                 170                 175     


Phe Asn Ile Ser Lys Ala Asp Asp Ala Arg Val Tyr Gly Lys Lys Ile 
            180                 185                 190         


Arg Asn Gly Met Arg His Leu Phe Arg Gly Phe His Asp Pro Cys Glu 
        195                 200                 205             


Glu Gly Lys Val Cys Tyr Leu Thr Ile Asn Gln Cys Gly Asp Pro Ser 
    210                 215                 220                 


Ser Phe Asp Tyr Cys Gly Val Asn His Leu Ser Lys Cys Gln Phe Asp 
225                 230                 235                 240 


His Val Asn Thr Leu Cys Phe Leu Val Arg Ser Lys Thr His Leu Asn 
                245                 250                 255     


Phe Glu Arg Arg Arg Arg Ala Phe Phe Ser Trp Ser Leu Thr Asp Ser 
            260                 265                 270         


Ser Gly Lys Asp Met Pro Gly Gly Tyr Cys Leu Glu Glu Trp Met Leu 
        275                 280                 285             


Ile Ala Ala Lys Met Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys 
    290                 295                 300                 


Asn Gln Asn His Asp Ser Glu Phe Cys Asp Met Leu Arg Leu Phe Asp 
305                 310                 315                 320 


Tyr Asn Lys Asn Ala Ile Lys Thr Leu Pro Asp Glu Ser Lys Lys Glu 
                325                 330                 335     


Ile Asn Leu Leu Ser Gln Thr Val Asn Ala Leu Ile Ser Asp Asn Leu 
            340                 345                 350         


Cys Met Lys Asn Lys Ile Lys Glu Leu Met Ser Ile Pro Tyr Cys Asn 
        355                 360                 365             


Tyr Thr Lys Phe Trp Tyr Val Asn His Thr Leu Thr Gly Gln His Thr 
    370                 375                 380                 


Leu Pro Arg Cys Trp Leu Ile Arg Asn Gly Ser Tyr Leu Asn Thr Ser 
385                 390                 395                 400 


Glu Phe Arg Asn Asp Trp Ile Leu Glu Ser Asp His Leu Ile Ser Glu 
                405                 410                 415     


Met Leu Ser Lys Glu Tyr Ala Glu Arg Gln Gly 
            420                 425         


<210>  11
<211>  416
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Met Gly Gln Phe Ile Ser Phe Met Gln Glu Ile Pro Thr Phe Leu Gln 
1               5                   10                  15      


Glu Ala Leu Asn Ile Ala Leu Val Ala Val Ser Leu Ile Ala Ile Ile 
            20                  25                  30          


Lys Gly Ile Val Asn Leu Tyr Lys Ser Gly Leu Phe Gln Phe Phe Val 
        35                  40                  45              


Phe Leu Ala Leu Ala Gly Arg Ser Cys Thr Glu Glu Ala Phe Lys Ile 
    50                  55                  60                  


Gly Leu His Thr Glu Phe Gln Thr Val Ser Phe Ser Met Val Gly Leu 
65                  70                  75                  80  


Phe Ser Asn Asn Pro His Asp Leu Pro Leu Leu Cys Thr Leu Asn Lys 
                85                  90                  95      


Ser His Leu Tyr Ile Lys Gly Gly Asn Ala Ser Phe Gln Ile Ser Phe 
            100                 105                 110         


Asp Asp Ile Ala Val Leu Leu Pro Gln Tyr Asp Val Ile Ile Gln His 
        115                 120                 125             


Pro Ala Asp Met Ser Trp Cys Ser Lys Ser Asp Asp Gln Ile Trp Leu 
    130                 135                 140                 


Ser Gln Trp Phe Met Asn Ala Val Gly His Gly Trp His Leu Asp Pro 
145                 150                 155                 160 


Pro Phe Leu Cys Arg Asn Arg Thr Lys Thr Glu Gly Phe Ile Phe Gln 
                165                 170                 175     


Val Asn Thr Ser Lys Thr Ser Val Asn Glu Asn Tyr Ala Asn Lys Phe 
            180                 185                 190         


Lys Thr Gly Met His His Leu Tyr Arg Glu Tyr Pro Asp Ser Cys Pro 
        195                 200                 205             


Asn Gly Lys Leu Cys Leu Met Lys Ala Gln Pro Thr Ser Trp Pro Pro 
    210                 215                 220                 


Gln Cys Pro Leu Asp His Val Asn Thr Leu Cys Phe Leu Thr Arg Gly 
225                 230                 235                 240 


Lys Asn Ile Gln Leu Pro Arg Arg Arg Arg Arg Ala Phe Phe Ser Trp 
                245                 250                 255     


Ser Leu Thr Asp Ser Ser Gly Lys Asp Thr Pro Gly Gly Tyr Cys Leu 
            260                 265                 270         


Glu Glu Trp Met Leu Val Ala Ala Lys Met Lys Cys Phe Gly Asn Thr 
        275                 280                 285             


Ala Val Ala Lys Cys Asn Leu Asn His Asp Ser Glu Phe Cys Asp Met 
    290                 295                 300                 


Leu Arg Leu Phe Asp Tyr Asn Lys Asn Ala Ile Lys Thr Leu Pro Asp 
305                 310                 315                 320 


Glu Thr Lys Lys Gln Val Asn Leu Met Gly Gln Thr Ile Asn Ala Leu 
                325                 330                 335     


Ile Ser Asp Asn Leu Cys Met Lys Asn Lys Ile Arg Glu Leu Met Ser 
            340                 345                 350         


Val Pro Tyr Cys Asn Tyr Thr Lys Phe Trp Tyr Val Asn His Thr Leu 
        355                 360                 365             


Ser Gly Gln His Ser Leu Pro Arg Cys Trp Leu Ile Lys Asn Asn Ser 
    370                 375                 380                 


Tyr Leu Asn Ile Ser Asp Phe Arg Asn Asp Trp Ile Leu Glu Ser Asp 
385                 390                 395                 400 


Phe Leu Ile Ser Glu Met Leu Ser Lys Glu Tyr Ser Asp Arg Gln Gly 
                405                 410                 415     


<210>  12
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Arg Arg Leu Ala 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Arg Ser Leu Lys 
1               


