                         SEQUENCE LISTING

<110>  Imperial Innovations Ltd
 
<120>  Polypeptides

<130>  P60410WO

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  2
<211>  8442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt gccagggacc       60

ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct tttcggaagt      120

gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg cagttacctc      180

ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca gaatggcaag      240

agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt tgtcaatggt      300

accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg gctgtatcta      360

gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt ggccaggatc      420

gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa gacctgcggg      480

ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga agggaccttg      540

acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga acagtggtgt      600

gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat gcagaagggc      660

ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg ccaccctctg      720

gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg tgctgggggg      780

ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca ggagggaatg      840

gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc tggtatggag      900

tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat caatgaaatg      960

tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct ggatgaaggc     1020

ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta ccctcccggc     1080

acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg gatctgcagc     1140

aatgaagaat gtccagggga gtgccttgtc actggtcaat cccacttcaa gagctttgac     1200

aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga ttgccaggac     1260

cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga cgctgtgtgc     1320

acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa actgaagcat     1380

ggggcaggag ttgccatgga tggccaggac atccagctcc ccctcctgaa aggtgacctc     1440

cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga cctgcagatg     1500

gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctacgc cgggaagacc     1560

tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac cccctctggg     1620

ctggcagagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg ggactgccag     1680

gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac caggttctcc     1740

gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg tgccgtcagc     1800

ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga cggccgcgag     1860

tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg cgtgcgcgtc     1920

gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt gtacctgcag     1980

tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga ggaatgcaat     2040

gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga gaggggggac     2100

tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca gccagaagac     2160

atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca ctgtaccatg     2220

agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct gtctcatcgc     2280

agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc cgctgacaac     2340

ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct ggagtgcatg     2400

agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca tgagaacaga     2460

tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc ccctggagaa     2520

acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa ctgcacagac     2580

catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac cttcgacggg     2640

ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta ctgcggcagt     2700

aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc ctcagtgaaa     2760

tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt tgacggggag     2820

gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga gtctggccgg     2880

tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca cctgagcatc     2940

tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg gaattttgat     3000

ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga ccctgtggac     3060

tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt gcctctggac     3120

tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga ttcctcctgt     3180

agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc cgagccatat     3240

ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg cgcctgcttc     3300

tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt ggtgacctgg     3360

aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga gaacgggtat     3420

gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg tcagcaccct     3480

gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg ccctccaggg     3540

aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc agtgtgtgag     3600

gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag tgaccctgag     3660

cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg ccaggagccg     3720

ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct gtatgtggag     3780

gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga cctggtcttc     3840

ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa ggcctttgtg     3900

gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc cgtggtggag     3960

taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc gtcagagctg     4020

cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac cagcgaggtc     4080

ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc ctcccgcatc     4140

gccctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt tgtccgctac     4200

gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg gccccatgcc     4260

aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc cttcgtgctg     4320

agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct ctgtgacctt     4380

gcccctgaag cccctcctcc tactctgccc ccccacatgg cacaagtcac tgtgggcccg     4440

gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct ggatgtggcg     4500

ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag caaggagttc     4560

atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt cacggtgctg     4620

cagtactcct acatggtgac cgtggagtac cccttcagcg aggcacagtc caaaggggac     4680

atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa cactgggctg     4740

gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg ggagcaggcg     4800

cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa gaggctgcct     4860

ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca ggagctggag     4920

aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct cccccgagag     4980

gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat ccccaccctc     5040

tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga tggctcctcc     5100

agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt catttcaaaa     5160

gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag catcaccacc     5220

attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct tgtggacgtc     5280

atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc tgtgcgatac     5340

ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt catcctggtc     5400

acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc caacagagtg     5460

acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg gatcttggca     5520

ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct ccctaccatg     5580

gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag gatttgcatg     5640

gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga ccagtgccac     5700

accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt caactgtgac     5760

cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga agagacctgt     5820

ggctgccgct ggacctgccc ctgcgtgtgc acaggcagct ccactcggca catcgtgacc     5880

tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt tcaaaacaag     5940

gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc aaggcagggc     6000

tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagctgca cagtgacatg     6060

gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa catggaagtc     6120

aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca catcttcaca     6180

ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt tgcttcaaag     6240

acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat gctgagggat     6300

ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca gcggccaggg     6360

cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc ccactgccag     6420

gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc cacattctat     6480

gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat cgcctcttat     6540

gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga tttctgtgct     6600

atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc ccggcactgt     6660

gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg ccctccagat     6720

aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg cattggtgag     6780

gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc ctgtcagatc     6840

tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc cacggccaaa     6900

gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga ccagtgctgc     6960

cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt gcctcactgt     7020

gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa cttcacctgc     7080

gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc gcaccgtttg     7140

cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa ctgtgtcaac     7200

tccacagtga gctgtcccct tgggtacttg gcctcaaccg ccaccaatga ctgtggctgt     7260

accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat ctaccctgtg     7320

ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga ggatgccgtg     7380

atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg tcggtcgggc     7440

ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc tgcctgtgag     7500

gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt cggctcccag     7560

tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa ggaggaggtc     7620

tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg cccctcgggc     7680

tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga gcgcatggag     7740

gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat cgatgtgtgc     7800

acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct ggagtgcagg     7860

aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac aggtgaatgt     7920

tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca gatcatgaca     7980

ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa ggtcaatgag     8040

agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga tgaacacaag     8100

tgtctggctg agggaggtaa aattatgaaa attccaggca cctgctgtga cacatgtgag     8160

gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg aagctgtaag     8220

tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa agccatgtac     8280

tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac acggacggag     8340

cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga ggttctcaat     8400

gccatggagt gcaaatgctc ccccaggaag tgcagcaagt ga                        8442


<210>  3
<211>  1967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Glu  Pro Glu Cys 
    1865                 1870                 1875             


Asn Asp  Ile Thr Ala Arg Leu  Gln Tyr Val Lys Val  Gly Ser Cys 
    1880                 1885                 1890             


Lys Ser  Glu Val Glu Val Asp  Ile His Tyr Cys Gln  Gly Lys Cys 
    1895                 1900                 1905             


Ala Ser  Lys Ala Met Tyr Ser  Ile Asp Ile Asn Asp  Val Gln Asp 
    1910                 1915                 1920             


Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr Glu Pro  Met Gln Val 
    1925                 1930                 1935             


Ala Leu  His Cys Thr Asn Gly  Ser Val Val Tyr His  Glu Val Leu 
    1940                 1945                 1950             


Asn Ala  Met Glu Cys Lys Cys  Ser Pro Arg Lys Cys  Ser Lys 
    1955                 1960                 1965         


<210>  4
<211>  5904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt gccagggacc       60

ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct tttcggaagt      120

gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg cagttacctc      180

ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca gaatggcaag      240

agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt tgtcaatggt      300

acggtgacac agggggacca aagagtctcc atgccctatg cctccaaagg gctgtatcta      360

gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt ggccaggatc      420

gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa gacctgcggg      480

ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga agggaccttg      540

acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga acagtggtgt      600

gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat gcagaagggc      660

ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg ccaccctctg      720

gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg tgctgggggg      780

ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca ggagggaatg      840

gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc tggtatggag      900

tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat caatgaaatg      960

tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct ggatgaaggc     1020

ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta ccctcccggc     1080

acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg gatctgcagc     1140

aatgaagaat gtccagggga gtgccttgtc actggtcaat cccacttcaa gagctttgac     1200

aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga ttgccaggac     1260

cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga cgctgtgtgc     1320

acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa actgaagcat     1380

ggggcaggag ttgccatgga tggccaggac atccagctcc ccctcctgaa aggtgacctc     1440

cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga cctgcagatg     1500

gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctacgc cgggaagacc     1560

tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac cccctctggg     1620

ctggcagagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg ggactgccag     1680

gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac caggttctcc     1740

gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg tgccgtcagc     1800

ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga cggccgcgag     1860

tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg cgtgcgcgtc     1920

gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt gtacctgcag     1980

tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga ggaatgcaat     2040

gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga gaggggggac     2100

tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca gccagaagac     2160

atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca ctgtaccatg     2220

agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct gtctcatcgc     2280

agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc cgctgacaac     2340

ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct ggagtgcatg     2400

agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca tgagaacaga     2460

tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc ccctggagaa     2520

acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa ctgcacagac     2580

catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac cttcgacggg     2640

ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta ctgcggcagt     2700

aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc ctcagtgaaa     2760

tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt tgacggggag     2820

gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga gtctggccgg     2880

tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca cctgagcatc     2940

tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg gaattttgat     3000

ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga ccctgtggac     3060

tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt gcctctggac     3120

tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga ttcctcctgt     3180

agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc cgagccatat     3240

ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg cgcctgcttc     3300

tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt ggtgacctgg     3360

aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga gaacgggtat     3420

gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg tcagcaccct     3480

gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg ccctccaggg     3540

aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc agtgtgtgag     3600

gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag tgaccctgag     3660

cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg ccaggagccg     3720

ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct gtatgtggag     3780

gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga cctggtcttc     3840

ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa ggcctttgtg     3900

gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc cgtggtggag     3960

taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc gtcagagctg     4020

cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac cagcgaggtc     4080

ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc ctcccgcatc     4140

gccctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt tgtccgctac     4200

gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg gccccatgcc     4260

aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc cttcgtgctg     4320

agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct ctgtgacctt     4380

gcccctgaag cccctcctcc tactctgccc ccccacatgg cacaagtcac tgtgggcccg     4440

gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct ggatgtggcg     4500

ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag caaggagttc     4560

atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt cacggtgctg     4620

cagtactcct acatggtgac cgtggagtac cccttcagcg aggcacagtc caaaggggac     4680

atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa cactgggctg     4740

gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg ggagcaggcg     4800

cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa gaggctgcct     4860

ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca ggagctggag     4920

aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct cccccgagag     4980

gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat ccccaccctc     5040

tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga tggctcctcc     5100

agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt catttcaaaa     5160

gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag catcaccacc     5220

attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct tgtggacgtc     5280

atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc tgtgcgatac     5340

ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt catcctggtc     5400

acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc caacagagtg     5460

acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg gatcttggca     5520

ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct ccctaccatg     5580

gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gagagcctga gtgcaacgac     5640

atcactgcca ggctgcagta tgtcaaggtg ggaagctgta agtctgaagt agaggtggat     5700

atccactact gccagggcaa atgtgccagc aaagccatgt actccattga catcaacgat     5760

gtgcaggacc agtgctcctg ctgctctccg acacggacgg agcccatgca ggtggccctg     5820

cactgcacca atggctctgt tgtgtaccat gaggttctca atgccatgga gtgcaaatgc     5880

tcccccagga agtgcagcaa gtga                                            5904


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys 
            20          


<210>  6
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg 
            740     


<210>  7
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp 
            100     


<210>  8
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
1               5                   10                  15      


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
            20                  25                  30          


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
        35                  40                  45              


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
    50                  55                  60                  


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
65                  70                  75                  80  


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
                85                  90                  95      


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
            100                 105                 110         


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
        115                 120                 125             


Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr 
    130                 135                 140                 


Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser 
145                 150                 155                 160 


Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp 
                165                 170                 175     


Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val 
            180                 185                 190         


Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn 
        195                 200                 205             


Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr 
    210                 215                 220                 


Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile 
225                 230                 235                 240 


Ala Ala Tyr Ala His Val Cys Ala Gln His Gly Lys Val Val Thr Trp 
                245                 250                 255     


Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg 
            260                 265                 270         


Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala 
        275                 280                 285             


Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln 
    290                 295                 300                 


Cys Val Glu Gly Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp 
305                 310                 315                 320 


Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu 
                325                 330                 335     


Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro 
            340                 345                 350         


Ser Asp Pro Glu His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu 
        355                 360                 365             


Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr 
    370                 375                 380                 


Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu 
385                 390                 395                 400 


Pro Pro Leu His Asp Phe 
                405     


<210>  9
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser 
1               5                   10                  15      


Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp 
            20                  25                  30          


Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val 
        35                  40                  45              


Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg 
    50                  55                  60                  


Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala 
65                  70                  75                  80  


Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe 
                85                  90                  95      


Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu 
            100                 105                 110         


Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val 
        115                 120                 125             


Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val 
    130                 135                 140                 


Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys 
145                 150                 155                 160 


Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu 
                165                 170                 175     


Glu Gln Gln Arg Asp Glu Ile 
            180             


<210>  10
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro Thr Leu 
1               5                   10                  15      


Pro Pro His Met Ala Gln Val Thr Val Gly Pro Gly Leu Leu Gly Val 
            20                  25                  30          


Ser Thr Leu Gly Pro Lys Arg Asn Ser Met Val Leu 
        35                  40                  


<210>  11
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp 
1               5                   10                  15      


Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp 
            20                  25                  30          


Val Gly Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met 
        35                  40                  45              


Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile 
    50                  55                  60                  


Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn 
65                  70                  75                  80  


Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser 
                85                  90                  95      


Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly 
            100                 105                 110         


Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val 
        115                 120                 125             


Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg 
    130                 135                 140                 


Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu 
145                 150                 155                 160 


Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg Cys Cys 
                165                 170             


<210>  12
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp Cys 
1               5                   10                  15      


Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe 
            20                  25                  30          


Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile 
        35                  40                  45              


Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln 
    50                  55                  60                  


Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu 
65                  70                  75                  80  


Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly Gly 
                85                  90                  95      


Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu Thr 
            100                 105                 110         


Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val Ile 
        115                 120                 125             


Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp Ala 
    130                 135                 140                 


Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp Arg 
145                 150                 155                 160 


Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp Ser 
                165                 170                 175     


Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val Thr 
            180                 185                 190         


Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly 
        195                 200                 


<210>  13
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Phe Val Arg Ile Cys Met Asp Glu Asp Gly Asn Glu Lys Arg Pro Gly 
1               5                   10                  15      


Asp Val Trp Thr Leu Pro Asp Gln Cys His Thr Val Thr Cys Gln Pro 
            20                  25                  30          


Asp Gly Gln Thr Leu Leu Lys Ser His Arg Val Asn Cys Asp Arg Gly 
        35                  40                  45              


Leu Arg Pro Ser Cys Pro Asn Ser Gln Ser Pro Val Lys Val Glu Glu 
    50                  55                  60                  


Thr Cys Gly Cys Arg Trp Thr Cys Pro Cys Val Cys Thr Gly Ser Ser 
65                  70                  75                  80  


Thr Arg His Ile Val Thr Phe Asp Gly Gln Asn Phe Lys Leu Thr Gly 
                85                  90                  95      


Ser Cys Ser Tyr Val Leu Phe Gln Asn Lys Glu Gln Asp Leu Glu Val 
            100                 105                 110         


Ile Leu His Asn Gly Ala Cys Ser Pro Gly Ala Arg Gln Gly Cys Met 
        115                 120                 125             


Lys Ser Ile Glu Val Lys His Ser Ala Leu Ser Val Glu Leu His Ser 
    130                 135                 140                 


Asp Met Glu Val Thr Val Asn Gly Arg Leu Val Ser Val Pro Tyr Val 
145                 150                 155                 160 


Gly Gly Asn Met Glu Val Asn Val Tyr Gly Ala Ile Met His Glu Val 
                165                 170                 175     


Arg Phe Asn His Leu Gly His Ile Phe Thr Phe Thr Pro Gln Asn Asn 
            180                 185                 190         


Glu Phe Gln Leu Gln Leu Ser Pro Lys Thr Phe Ala Ser Lys Thr Tyr 
        195                 200                 205             


Gly Leu Cys Gly Ile Cys Asp Glu Asn Gly Ala Asn Asp Phe Met Leu 
    210                 215                 220                 


Arg Asp Gly Thr Val Thr Thr Asp Trp Lys Thr Leu Val Gln Glu Trp 
225                 230                 235                 240 


Thr Val Gln Arg Pro Gly Gln Thr Cys Gln Pro Ile Leu Glu Glu Gln 
                245                 250                 255     


Cys Leu Val Pro Asp Ser Ser His Cys Gln Val Leu Leu Leu Pro Leu 
            260                 265                 270         


Phe Ala Glu Cys His Lys Val Leu Ala Pro Ala Thr Phe Tyr Ala Ile 
        275                 280                 285             


Cys Gln Gln Asp Ser Cys His Gln Glu Gln Val Cys Glu Val Ile Ala 
    290                 295                 300                 


Ser Tyr Ala His Leu Cys Arg Thr Asn Gly Val Cys Val Asp Trp Arg 
305                 310                 315                 320 


Thr Pro Asp Phe Cys Ala Met Ser Cys Pro Pro Ser Leu Val Tyr Asn 
                325                 330                 335     


His Cys Glu His Gly Cys Pro Arg His Cys Asp Gly Asn Val Ser Ser 
            340                 345                 350         


Cys Gly Asp His Pro Ser Glu Gly Cys Phe Cys Pro Pro Asp Lys Val 
        355                 360                 365             


Met Leu Glu Gly Ser Cys Val Pro Glu Glu Ala Cys 
    370                 375                 380 


<210>  14
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Thr Gln Cys Ile Gly Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala 
1               5                   10                  15      


Trp Val Pro Asp His Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly 
            20                  25                  30          


Arg Lys Val Asn Cys Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro 
        35                  40                  45              


Thr Cys Gly Leu Cys Glu Val Ala Arg Leu Arg Gln Asn Ala Asp Gln 
    50                  55                  60                  


Cys Cys Pro Glu Tyr Glu Cys Val Cys Asp Pro Val Ser Cys Asp 
65                  70                  75                  


<210>  15
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Leu Pro Pro Val Pro His Cys Glu Arg Gly Leu Gln Pro Thr Leu Thr 
1               5                   10                  15      


Asn Pro Gly Glu Cys Arg Pro Asn Phe Thr Cys Ala Cys Arg Lys Glu 
            20                  25                  30          


Glu Cys Lys Arg Val Ser Pro Pro Ser Cys Pro Pro His Arg Leu Pro 
        35                  40                  45              


Thr Leu Arg Lys Thr Gln Cys Cys Asp Glu Tyr Glu Cys Ala Cys Asn 
    50                  55                  60                  


Cys Val Asn Ser Thr 
65                  


<210>  16
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Val Ser Cys Pro Leu Gly Tyr Leu Ala Ser Thr Ala Thr Asn Asp Cys 
1               5                   10                  15      


Gly Cys Thr Thr Thr Thr Cys Leu Pro Asp 
            20                  25      


<210>  17
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Lys Val Cys Val His Arg Ser Thr Ile Tyr Pro Val Gly Gln Phe Trp 
1               5                   10                  15      


Glu Glu Gly Cys Asp Val Cys Thr Cys Thr Asp Met Glu Asp Ala Val 
            20                  25                  30          


Met Gly Leu Arg Val Ala Gln Cys Ser Gln Lys Pro Cys Glu Asp Ser 
        35                  40                  45              


Cys Arg Ser Gly Phe Thr Tyr Val Leu His Glu Gly Glu Cys Cys Gly 
    50                  55                  60                  


Arg Cys Leu Pro 
65              


<210>  18
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Ser Ala Cys Glu Val Val Thr Gly Ser Pro Arg Gly Asp Ser Gln Ser 
1               5                   10                  15      


Ser Trp Lys Ser Val Gly Ser Gln Trp Ala Ser Pro Glu Asn Pro Cys 
            20                  25                  30          


Leu Ile Asn Glu Cys Val Arg Val Lys Glu Glu Val Phe Ile Gln Gln 
        35                  40                  45              


Arg Asn Val Ser Cys Pro Gln Leu Glu Val Pro Val Cys Pro Ser Gly 
    50                  55                  60                  


Phe Gln Leu Ser Cys Lys Thr Ser Ala Cys Cys Pro Ser Cys Arg Cys 
65                  70                  75                  80  


Glu 
    


<210>  19
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Arg Met Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly Pro Gly Lys 
1               5                   10                  15      


Thr Val Met Ile Asp Val Cys Thr Thr Cys Arg Cys Met Val Gln Val 
            20                  25                  30          


Gly Val Ile Ser Gly Phe Lys Leu Glu Cys Arg Lys Thr Thr Cys Asn 
        35                  40                  45              


Pro Cys Pro Leu Gly Tyr Lys Glu Glu Asn Asn Thr Gly Glu Cys Cys 
    50                  55                  60                  


Gly Arg Cys Leu Pro 
65                  


<210>  20
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Thr Ala Cys Thr Ile Gln Leu Arg Gly Gly Gln Ile Met Thr Leu Lys 
1               5                   10                  15      


Arg Asp Glu Thr Leu Gln Asp Gly Cys Asp Thr His Phe Cys Lys Val 
            20                  25                  30          


Asn Glu Arg Gly Glu Tyr Phe Trp Glu Lys Arg Val Thr Gly Cys Pro 
        35                  40                  45              


Pro Phe Asp Glu His Lys Cys Leu Ala Glu Gly Gly Lys Ile Met Lys 
    50                  55                  60                  


Ile Pro Gly Thr Cys Cys Asp Thr Cys Glu 
65                  70                  


<210>  21
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Glu Pro Glu Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val 
1               5                   10                  15      


Gly Ser Cys Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly 
            20                  25                  30          


Lys Cys Ala Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val Gln 
        35                  40                  45              


Asp Gln Cys Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met Gln Val 
    50                  55                  60                  


Ala Leu His Cys Thr Asn Gly Ser Val Val Tyr His Glu Val Leu Asn 
65                  70                  75                  80  


Ala Met Glu Cys Lys Cys Ser Pro Arg Lys Cys Ser Lys 
                85                  90              


<210>  22
<211>  2538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
tttgttagga tttgcatgga tgaggatggg aatgagaaga ggcccgggga cgtctggacc       60

ttgccagacc agtgccacac cgtgacttgc cagccagatg gccagacctt gctgaagagt      120

catcgggtca actgtgaccg ggggctgagg ccttcgtgcc ctaacagcca gtcccctgtt      180

aaagtggaag agacctgtgg ctgccgctgg acctgcccct gcgtgtgcac aggcagctcc      240

actcggcaca tcgtgacctt tgatgggcag aatttcaagc tgactggcag ctgttcttat      300

gtcctatttc aaaacaagga gcaggacctg gaggtgattc tccataatgg tgcctgcagc      360

cctggagcaa ggcagggctg catgaaatcc atcgaggtga agcacagtgc cctctccgtc      420

gagctgcaca gtgacatgga ggtgacggtg aatgggagac tggtctctgt tccttacgtg      480

ggtgggaaca tggaagtcaa cgtttatggt gccatcatgc atgaggtcag attcaatcac      540

cttggtcaca tcttcacatt cactccacaa aacaatgagt tccaactgca gctcagcccc      600

aagacttttg cttcaaagac gtatggtctg tgtgggatct gtgatgagaa cggagccaat      660

gacttcatgc tgagggatgg cacagtcacc acagactgga aaacacttgt tcaggaatgg      720

actgtgcagc ggccagggca gacgtgccag cccatcctgg aggagcagtg tcttgtcccc      780

gacagctccc actgccaggt cctcctctta ccactgtttg ctgaatgcca caaggtcctg      840

gctccagcca cattctatgc catctgccag caggacagtt gccaccagga gcaagtgtgt      900

gaggtgatcg cctcttatgc ccacctctgt cggaccaacg gggtctgcgt tgactggagg      960

acacctgatt tctgtgctat gtcatgccca ccatctctgg tctacaacca ctgtgagcat     1020

ggctgtcccc ggcactgtga tggcaacgtg agctcctgtg gggaccatcc ctccgaaggc     1080

tgtttctgcc ctccagataa agtcatgttg gaaggcagct gtgtccctga agaggcctgc     1140

actcagtgca ttggtgagga tggagtccag caccagttcc tggaagcctg ggtcccggac     1200

caccagccct gtcagatctg cacatgcctc agcgggcgga aggtcaactg cacaacgcag     1260

ccctgcccca cggccaaagc tcccacgtgt ggcctgtgtg aagtagcccg cctccgccag     1320

aatgcagacc agtgctgccc cgagtatgag tgtgtgtgtg acccagtgag ctgtgacctg     1380

cccccagtgc ctcactgtga acgtggcctc cagcccacac tgaccaaccc tggcgagtgc     1440

agacccaact tcacctgcgc ctgcaggaag gaggagtgca aaagagtgtc cccaccctcc     1500

tgccccccgc accgtttgcc cacccttcgg aagacccagt gctgtgatga gtatgagtgt     1560

gcctgcaact gtgtcaactc cacagtgagc tgtccccttg ggtacttggc ctcaaccgcc     1620

accaatgact gtggctgtac cacaaccacc tgccttcccg acaaggtgtg tgtccaccga     1680

agcaccatct accctgtggg ccagttctgg gaggagggct gcgatgtgtg cacctgcacc     1740

gacatggagg atgccgtgat gggcctccgc gtggcccagt gctcccagaa gccctgtgag     1800

gacagctgtc ggtcgggctt cacttacgtt ctgcatgaag gcgagtgctg tggaaggtgc     1860

ctgccatctg cctgtgaggt ggtgactggc tcaccgcggg gggactccca gtcttcctgg     1920

aagagtgtcg gctcccagtg ggcctccccg gagaacccct gcctcatcaa tgagtgtgtc     1980

cgagtgaagg aggaggtctt tatacaacaa aggaacgtct cctgccccca gctggaggtc     2040

cctgtctgcc cctcgggctt tcagctgagc tgtaagacct cagcgtgctg cccaagctgt     2100

cgctgtgagc gcatggaggc ctgcatgctc aatggcactg tcattgggcc cgggaagact     2160

gtgatgatcg atgtgtgcac gacctgccgc tgcatggtgc aggtgggggt catctctgga     2220

ttcaagctgg agtgcaggaa gaccacctgc aacccctgcc ccctgggtta caaggaagaa     2280

aataacacag gtgaatgttg tgggagatgt ttgcctacgg cttgcaccat tcagctaaga     2340

ggaggacaga tcatgacact gaagcgtgat gagacgctcc aggatggctg tgatactcac     2400

ttctgcaagg tcaatgagag aggagagtac ttctgggaga agagggtcac aggctgccca     2460

ccctttgatg aacacaagtg tctggctgag ggaggtaaaa ttatgaaaat tccaggcacc     2520

tgctgtgaca catgtgag                                                   2538


<210>  23
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys 
            20          


<210>  24
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg 
            740     


<210>  25
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp 
1               5                   10                  15      


Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr 
            20                  25                  30          


Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro 
        35                  40                  45              


Pro Gly Met Val Arg His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys 
    50                  55                  60                  


Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys 
65                  70                  75                  80  


Ile Gly Cys Asn Thr Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr 
                85                  90                  95      


Asp His Val Cys Asp 
            100     


<210>  26
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
1               5                   10                  15      


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
            20                  25                  30          


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
        35                  40                  45              


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
    50                  55                  60                  


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
65                  70                  75                  80  


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
                85                  90                  95      


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
            100                 105                 110         


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
        115                 120                 125             


Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr 
    130                 135                 140                 


Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser 
145                 150                 155                 160 


Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp 
                165                 170                 175     


Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val 
            180                 185                 190         


Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn 
        195                 200                 205             


Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr 
    210                 215                 220                 


Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile 
225                 230                 235                 240 


Ala Ala Tyr Ala His Val Cys Ala Gln His Gly Lys Val Val Thr Trp 
                245                 250                 255     


Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg 
            260                 265                 270         


Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala 
        275                 280                 285             


Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln 
    290                 295                 300                 


Cys Val Glu Gly Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp 
305                 310                 315                 320 


Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu 
                325                 330                 335     


Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro 
            340                 345                 350         


Ser Asp Pro Glu His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu 
        355                 360                 365             


Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr 
    370                 375                 380                 


Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu 
385                 390                 395                 400 


Pro Pro Leu His Asp Phe 
                405     


<210>  27
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly Ser Ser 
1               5                   10                  15      


Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val Val Asp 
            20                  25                  30          


Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val Ala Val 
        35                  40                  45              


Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys Asp Arg 
    50                  55                  60                  


Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala 
65                  70                  75                  80  


Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe 
                85                  90                  95      


Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu 
            100                 105                 110         


Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val 
        115                 120                 125             


Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val 
    130                 135                 140                 


Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys 
145                 150                 155                 160 


Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu 
                165                 170                 175     


Glu Gln Gln Arg Asp Glu Ile 
            180             


<210>  28
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Val Ser Tyr Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro Thr Leu 
1               5                   10                  15      


Pro Pro His Met Ala Gln Val Thr Val Gly Pro Gly Leu Leu Gly Val 
            20                  25                  30          


Ser Thr Leu Gly Pro Lys Arg Asn Ser Met Val Leu 
        35                  40                  


<210>  29
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp 
1               5                   10                  15      


Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp 
            20                  25                  30          


Val Gly Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met 
        35                  40                  45              


Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile 
    50                  55                  60                  


Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn 
65                  70                  75                  80  


Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser 
                85                  90                  95      


Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly 
            100                 105                 110         


Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val 
        115                 120                 125             


Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg 
    130                 135                 140                 


Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu 
145                 150                 155                 160 


Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg Cys Cys 
                165                 170             


<210>  30
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp Cys 
1               5                   10                  15      


Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe 
            20                  25                  30          


Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile 
        35                  40                  45              


Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln 
    50                  55                  60                  


Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu 
65                  70                  75                  80  


Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly Gly 
                85                  90                  95      


Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu Thr 
            100                 105                 110         


Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val Ile 
        115                 120                 125             


Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp Ala 
    130                 135                 140                 


Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp Arg 
145                 150                 155                 160 


Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp Ser 
                165                 170                 175     


Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val Thr 
            180                 185                 190         


Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly 
        195                 200                 


<210>  31
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Glu Pro Glu Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val 
1               5                   10                  15      


Gly Ser Cys Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly 
            20                  25                  30          


Lys Cys Ala Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val Gln 
        35                  40                  45              


Asp Gln Cys Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met Gln Val 
    50                  55                  60                  


Ala Leu His Cys Thr Asn Gly Ser Val Val Tyr His Glu Val Leu Asn 
65                  70                  75                  80  


Ala Met Glu Cys Lys Cys Ser Pro Arg Lys Cys Ser Lys 
                85                  90              


