                         SEQUENCE LISTING

<110>  Institute of Genetics and Developmental Biology, Chinese Academy of Sciences 
             KWS SAAT SE
 
<120>  Methods for isolating cells without the use of transgenic marker sequences

<130>  P20182491

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  5142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APOBEC1 XTEN nCas9(D10A) UGI NLS construct

<400>  1
atgagctcag agactggccc agtggctgtg gaccccacat tgagacggcg gatcgagccc       60

catgagtttg aggtattctt cgatccgaga gagctccgca aggagacctg cctgctttac      120

gaaattaatt gggggggccg gcactccatt tggcgacata catcacagaa cactaacaag      180

cacgtcgaag tcaacttcat cgagaagttc acgacagaaa gatatttctg tccgaacaca      240

aggtgcagca ttacctggtt tctcagctgg agcccatgcg gcgaatgtag tagggccatc      300

actgaattcc tgtcaaggta tccccacgtc actctgttta tttacatcgc aaggctgtac      360

caccacgctg acccccgcaa tcgacaaggc ctgcgggatt tgatctcttc aggtgtgact      420

atccaaatta tgactgagca ggagtcagga tactgctgga gaaactttgt gaattatagc      480

ccgagtaatg aagcccactg gcctaggtat ccccatctgt gggtacgact gtacgttctt      540

gaactgtact gcatcatact gggcctgcct ccttgtctca acattctgag aaggaagcag      600

ccacagctga cattctttac catcgctctt cagtcttgtc attaccagcg actgccccca      660

cacattctct gggccaccgg gttgaaaagc ggcagcgaga ctcccgggac ctcagagtcc      720

gccacacccg aaagtgataa aaagtattct attggtttag ccatcggcac taattccgtt      780

ggatgggctg tcataaccga tgaatacaaa gtaccttcaa agaaatttaa ggtgttgggg      840

aacacagacc gtcattcgat taaaaagaat cttatcggtg ccctcctatt cgatagtggc      900

gaaacggcag aggcgactcg cctgaaacga accgctcgga gaaggtatac acgtcgcaag      960

aaccgaatat gttacttaca agaaattttt agcaatgaga tggccaaagt tgacgattct     1020

ttctttcacc gtttggaaga gtccttcctt gtcgaagagg acaagaaaca tgaacggcac     1080

cccatctttg gaaacatagt agatgaggtg gcatatcatg aaaagtaccc aacgatttat     1140

cacctcagaa aaaagctagt tgactcaact gataaagcgg acctgaggtt aatctacttg     1200

gctcttgccc atatgataaa gttccgtggg cactttctca ttgagggtga tctaaatccg     1260

gacaactcgg atgtcgacaa actgttcatc cagttagtac aaacctataa tcagttgttt     1320

gaagagaacc ctataaatgc aagtggcgtg gatgcgaagg ctattcttag cgcccgcctc     1380

tctaaatccc gacggctaga aaacctgatc gcacaattac ccggagagaa gaaaaatggg     1440

ttgttcggta accttatagc gctctcacta ggcctgacac caaattttaa gtcgaacttc     1500

gacttagctg aagatgccaa attgcagctt agtaaggaca cgtacgatga cgatctcgac     1560

aatctactgg cacaaattgg agatcagtat gcggacttat ttttggctgc caaaaacctt     1620

agcgatgcaa tcctcctatc tgacatactg agagttaata ctgagattac caaggcgccg     1680

ttatccgctt caatgatcaa aaggtacgat gaacatcacc aagacttgac acttctcaag     1740

gccctagtcc gtcagcaact gcctgagaaa tataaggaaa tattctttga tcagtcgaaa     1800

aacgggtacg caggttatat tgacggcgga gcgagtcaag aggaattcta caagtttatc     1860

aaacccatat tagagaagat ggatgggacg gaagagttgc ttgtaaaact caatcgcgaa     1920

gatctactgc gaaagcagcg gactttcgac aacggtagca ttccacatca aatccactta     1980

ggcgaattgc atgctatact tagaaggcag gaggattttt atccgttcct caaagacaat     2040

cgtgaaaaga ttgagaaaat cctaaccttt cgcatacctt actatgtggg acccctggcc     2100

cgagggaact ctcggttcgc atggatgaca agaaagtccg aagaaacgat tactccatgg     2160

aattttgagg aagttgtcga taaaggtgcg tcagctcaat cgttcatcga gaggatgacc     2220

aactttgaca agaatttacc gaacgaaaaa gtattgccta agcacagttt actttacgag     2280

tatttcacag tgtacaatga actcacgaaa gttaagtatg tcactgaggg catgcgtaaa     2340

cccgcctttc taagcggaga acagaagaaa gcaatagtag atctgttatt caagaccaac     2400

cgcaaagtga cagttaagca attgaaagag gactacttta agaaaattga atgcttcgat     2460

tctgtcgaga tctccggggt agaagatcga tttaatgcgt cacttggtac gtatcatgac     2520

ctcctaaaga taattaaaga taaggacttc ctggataacg aagagaatga agatatctta     2580

gaagatatag tgttgactct taccctcttt gaagatcggg aaatgattga ggaaagacta     2640

aaaacatacg ctcacctgtt cgacgataag gttatgaaac agttaaagag gcgtcgctat     2700

acgggctggg gacgattgtc gcggaaactt atcaacggga taagagacaa gcaaagtggt     2760

aaaactattc tcgattttct aaagagcgac ggcttcgcca ataggaactt tatgcagctg     2820

atccatgatg actctttaac cttcaaagag gatatacaaa aggcacaggt ttccggacaa     2880

ggggactcat tgcacgaaca tattgcgaat cttgctggtt cgccagccat caaaaagggc     2940

atactccaga cagtcaaagt agtggatgag ctagttaagg tcatgggacg tcacaaaccg     3000

gaaaacattg taatcgagat ggcacgcgaa aatcaaacga ctcagaaggg gcaaaaaaac     3060

agtcgagagc ggatgaagag aatagaagag ggtattaaag aactgggcag ccagatctta     3120

aaggagcatc ctgtggaaaa tacccaattg cagaacgaga aactttacct ctattaccta     3180

caaaatggaa gggacatgta tgttgatcag gaactggaca taaaccgttt atctgattac     3240

gacgtcgatc acattgtacc ccaatccttt ttgaaggacg attcaatcga caataaagtg     3300

cttacacgct cggataagaa ccgagggaaa agtgacaatg ttccaagcga ggaagtcgta     3360

aagaaaatga agaactattg gcggcagctc ctaaatgcga aactgataac gcaaagaaag     3420

ttcgataact taactaaagc tgagaggggt ggcttgtctg aacttgacaa ggccggattt     3480

attaaacgtc agctcgtgga aacccgccaa atcacaaagc atgttgcaca gatactagat     3540

tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt caaagtaatc     3600

actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta taaagttagg     3660

gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt agggaccgca     3720

ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta caaagtttat     3780

gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac agccaaatac     3840

ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc aaacggagag     3900

atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt atgggataag     3960

ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa catagtaaag     4020

aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa aaggaatagt     4080

gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg cttcgatagc     4140

cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa atccaagaaa     4200

ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc ttttgaaaag     4260

aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga tctcataatt     4320

aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat gttggctagc     4380

gccggagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt gaatttcctg     4440

tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga acagaagcaa     4500

ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat ttcggaattc     4560

agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc atacaacaag     4620

cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt tactcttacc     4680

aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg caaacgatac     4740

acttctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac gggattatat     4800

gaaactcgga tagatttgtc acagcttggg ggtgactctg gtggttctac taatctgtca     4860

gatattattg aaaaggagac cggtaagcaa ctggttatcc aggaatccat cctcatgctc     4920

ccagaggagg tggaagaagt cattgggaac aagccggaaa gcgatatact cgtgcacacc     4980

gcctacgacg agagcaccga cgagaatgtc atgcttctga ctagcgacgc ccctgaatac     5040

aagccttggg ctctggtcat acaggatagc aacggtgaga acaagattaa gatgctctct     5100

ggtggttctc ccaagaagaa gaggaaagtc taagacgtct aa                        5142


<210>  2
<211>  5214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APOBEC1 XTEN nCas9(D10A) UGI NLS construct codon optimized

<400>  2
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggaaacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgaa      720

acgccaggca cctccgagag cgctacgcct gaacttaagg acaagaagta ctcgatcggc      780

ctcgccatcg ggacgaactc agttggctgg gccgtgatca ccgacgagta caaggtgccc      840

tctaagaagt tcaaggtcct ggggaacacc gaccgccatt ccatcaagaa gaacctcatc      900

ggcgctctcc tgttcgacag cggggagacc gctgaggcta cgaggctcaa gagaaccgct      960

aggcgccggt acacgagaag gaagaacagg atctgctacc tccaagagat tttctccaac     1020

gagatggcca aggttgacga ttcattcttc caccgcctgg aggagtcttt cctcgtggag     1080

gaggataaga agcacgagcg gcatcccatc ttcggcaaca tcgtggacga ggttgcctac     1140

cacgagaagt accctacgat ctaccatctg cggaagaagc tcgtggactc caccgataag     1200

gcggacctca gactgatcta cctcgctctg gcccacatga tcaagttccg cggccatttc     1260

ctgatcgagg gggatctcaa cccagacaac agcgatgttg acaagctgtt catccaactc     1320

gtgcagacct acaaccaact cttcgaggag aacccgatca acgcctctgg cgtggacgcg     1380

aaggctatcc tgtccgcgag gctctcgaag tccaggaggc tggagaacct gatcgctcag     1440

ctcccaggcg agaagaagaa cggcctgttc gggaacctca tcgctctcag cctggggctc     1500

accccgaact tcaagtcgaa cttcgatctc gctgaggacg ccaagctgca actctccaag     1560

gacacctacg acgatgacct cgataacctc ctggcccaga tcggcgatca atacgcggac     1620

ctgttcctcg ctgccaagaa cctgtcggac gccatcctcc tgtcagatat cctccgcgtg     1680

aacaccgaga tcacgaaggc tccactctct gcctccatga tcaagcgcta cgacgagcac     1740

catcaggatc tgaccctcct gaaggcgctg gtccgccaac agctcccgga gaagtacaag     1800

gagattttct tcgatcagtc gaagaacggc tacgctgggt acatcgacgg cggggcctca     1860

caagaggagt tctacaagtt catcaagcca atcctggaga agatggacgg cacggaggag     1920

ctcctggtga agctcaacag ggaggacctc ctgcggaagc agagaacctt cgataacggc     1980

agcatccccc accaaatcca tctcggggag ctgcacgcca tcctgagaag gcaagaggac     2040

ttctaccctt tcctcaagga taaccgggag aagatcgaga agatcctgac cttcagaatc     2100

ccatactacg tcggccctct cgcgcggggg aactcaagat tcgcttggat gacccgcaag     2160

tctgaggaga ccatcacgcc gtggaacttc gaggaggtgg tggacaaggg cgctagcgct     2220

cagtcgttca tcgagaggat gaccaacttc gacaagaacc tgcccaacga gaaggtgctc     2280

cctaagcact cgctcctgta cgagtacttc accgtctaca acgagctcac gaaggtgaag     2340

tacgtcaccg agggcatgcg caagccagcg ttcctgtccg gggagcagaa gaaggctatc     2400

gtggacctcc tgttcaagac caaccggaag gtcacggtta agcaactcaa ggaggactac     2460

ttcaagaaga tcgagtgctt cgattcggtc gagatcagcg gcgttgagga ccgcttcaac     2520

gccagcctcg ggacctacca cgatctcctg aagatcatca aggataagga cttcctggac     2580

aacgaggaga acgaggatat cctggaggac atcgtgctga ccctcacgct gttcgaggac     2640

agggagatga tcgaggagcg cctgaagacg tacgcccatc tcttcgatga caaggtcatg     2700

aagcaactca agcgccggag atacaccggc tgggggaggc tgtcccgcaa gctcatcaac     2760

ggcatccggg acaagcagtc cgggaagacc atcctcgact tcctcaagag cgatggcttc     2820

gccaacagga acttcatgca actgatccac gatgacagcc tcaccttcaa ggaggatatc     2880

caaaaggctc aagtgagcgg ccagggggac tcgctgcacg agcatatcgc gaacctcgct     2940

ggctcccccg cgatcaagaa gggcatcctc cagaccgtga aggttgtgga cgagctcgtg     3000

aaggtcatgg gccggcacaa gcctgagaac atcgtcatcg agatggccag agagaaccaa     3060

accacgcaga aggggcaaaa gaactctagg gagcgcatga agcgcatcga ggagggcatc     3120

aaggagctgg ggtcccaaat cctcaaggag cacccagtgg agaacaccca actgcagaac     3180

gagaagctct acctgtacta cctccagaac ggcagggata tgtacgtgga ccaagagctg     3240

gatatcaacc gcctcagcga ttacgatgtc gatcatatcg ttccccagtc tttcctgaag     3300

gatgactcca tcgacaacaa ggtcctcacc aggtcggaca agaaccgcgg caagtcagat     3360

aacgttccat ctgaggaggt cgttaagaag atgaagaact actggaggca gctcctgaac     3420

gccaagctga tcacgcaaag gaagttcgac aacctcacca aggctgagag aggcgggctc     3480

tcagagctgg acaaggccgg cttcatcaag cggcagctgg tcgagaccag acaaatcacg     3540

aagcacgttg cgcaaatcct cgactctcgg atgaacacga agtacgatga gaacgacaag     3600

ctgatcaggg aggttaaggt gatcaccctg aagtctaagc tcgtttccga cttcaggaag     3660

gatttccagt tctacaaggt tcgcgagatc aacaactacc accatgccca tgacgcttac     3720

ctcaacgctg tggtcggcac cgctctgatc aagaagtacc caaagctgga gtccgagttc     3780

gtgtacgggg actacaaggt ttacgatgtg cgcaagatga tcgccaagtc ggagcaagag     3840

atcggcaagg ctaccgccaa gtacttcttc tactcaaaca tcatgaactt cttcaagacc     3900

gagatcacgc tggccaacgg cgagatccgg aagagaccgc tcatcgagac caacggcgaa     3960

acgggggaga tcgtgtggga caagggcagg gatttcgcga ccgtccgcaa ggttctctcc     4020

atgccccagg tgaacatcgt caagaagacc gaggtccaaa cgggcgggtt ctcaaaggag     4080

tctatcctgc ctaagcggaa cagcgacaag ctcatcgcca gaaagaagga ctgggaccca     4140

aagaagtacg gcgggttcga cagccctacc gtggcctact cggtcctggt tgtggcgaag     4200

gttgagaagg gcaagtccaa gaagctcaag agcgtgaagg agctcctggg gatcaccatc     4260

atggagaggt ccagcttcga gaagaaccca atcgacttcc tggaggccaa gggctacaag     4320

gaggtgaaga aggacctgat catcaagctc ccgaagtact ctctcttcga gctggagaac     4380

ggcaggaaga gaatgctggc ttccgctggc gagctccaga aggggaacga gctcgcgctg     4440

ccaagcaagt acgtgaactt cctctacctg gcttcccact acgagaagct caagggcagc     4500

ccggaggaca acgagcaaaa gcagctgttc gtcgagcagc acaagcatta cctcgacgag     4560

atcatcgagc aaatctccga gttcagcaag cgcgtgatcc tcgccgacgc gaacctggat     4620

aaggtcctct ccgcctacaa caagcaccgg gacaagccca tcagagagca agcggagaac     4680

atcatccatc tcttcaccct gacgaacctc ggcgctcctg ctgctttcaa gtacttcgac     4740

accacgatcg atcggaagag atacacctcc acgaaggagg tcctggacgc gaccctcatc     4800

caccagtcga tcaccggcct gtacgaaacg aggatcgacc tctcacaact cggcggggat     4860

aagagacccg cagcaaccaa gaaggcaggg caagcaaaga agaagaagac gcgtgactcc     4920

ggcggcagca ccaacctgtc cgacatcatc gagaaggaaa cgggcaagca actcgtgatc     4980

caggagagca tcctcatgct gccagaggag gtggaggagg tcatcggcaa caagccagag     5040

tccgacatcc tggtgcacac cgcctacgac gagtccaccg acgagaacgt catgctcctg     5100

accagcgacg ccccagagta caagccatgg gccctcgtca tccaggacag caacggggag     5160

aacaagatca agatgctgtc gggggggagc ccaaagaaga agcggaaggt gtag           5214


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  3
caggtgccgc gacgcatgat                                                   20


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  4
cacgggacag gtgccgcgac g                                                 21


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  5
gggacaggtg ccgcgacgca                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  6
gccccaccac tagggatcat                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  7
atcaccagca tagacacctt                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  8
aggatcacca gcatagacac c                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  9
cttagaagga tcaccagcat                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  10
ctgagcagaa aggctcaatg                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  11
ataagcacct gagcagaaag g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  12
cctttctgct caggtgctta t                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  13
acctgagcag aaaggctcaa                                                   20


<210>  14
<211>  4047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APOBEC1 XTEN linker CasX1 UGI NLS codon optimized

<400>  14
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggaaacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgaa      720

acgccaggca cctccgagag cgctacgcct gaacttaagg agaagagaat taacaagatc      780

agaaaaaaat tgagcgccga caatgcgact aaaccagttt ccagaagcgg ccctatgaaa      840

acgctcctcg tgcgggtcat gacagatgac cttaaaaaac gccttgagaa gcgcagaaag      900

aaaccggaag tgatgcctca agttatttcc aataatgccg ccaataacct ccgcatgctt      960

ttggatgact acaccaaaat gaaggaagcg atacttcaag tttactggca agagttcaaa     1020

gatgatcacg ttggtcttat gtgtaaattt gcccaaccgg cctctaagaa gatagatcag     1080

aacaagctga agccagagat ggacgagaag ggaaatctca cgactgcggg cttcgcgtgc     1140

tcgcaatgtg gtcagcctct ctttgtgtat aaacttgagc aagtctcaga gaaggggaaa     1200

gcatatacga actacttcgg tagatgcaac gtggcagagc atgaaaaact tattttgctc     1260

gctcagctga aaccggagaa agactcggac gaagcagtta cttatagcct tggcaaattt     1320

ggccaaaggg cactcgactt ctatagcatc cacgtgacga aggaatctac gcatccagtg     1380

aaaccattgg cgcagattgc aggaaatcgc tatgcgtcgg gaccggtggg caaggccctt     1440

tcggatgcct gtatgggtac gatagcttcc tttttgtcaa agtaccaaga tataattatc     1500

gaacaccaaa aggtcgtcaa ggggaatcaa aagagattgg aaagtttgag ggagctcgct     1560

ggcaaggaga atctcgaata tccatcagtc acgctccctc cgcagccaca taccaaggaa     1620

ggggttgacg cttataatga ggttatcgcg cgggtccgca tgtgggtcaa cttgaatctt     1680

tggcaaaaac tcaaactgtc cagagatgat gcaaagcctt tgctcaggtt gaagggcttc     1740

ccttcgttcc cagtcgttga aaggagagaa aacgaagtcg attggtggaa cactatcaat     1800

gaagtgaaaa agctcattga tgctaagaga gacatgggta gggtcttttg gtctggagtt     1860

accgcagaaa agcggaatac tattctggaa ggctacaact atcttcccaa cgaaaacgac     1920

cacaagaaaa gggaggggag cctcgaaaat cccaaaaaac cggcgaaacg ccaatttggg     1980

gatctgcttc tttatctgga gaagaagtat gcaggcgact ggggaaaagt gtttgacgag     2040

gcttgggagc gcatcgacaa aaagatcgct ggcctcacat cacacataga aagggaggag     2100

gcaaggaatg cagaagatgc gcagagcaaa gcagttctta cggattggtt gcgcgctaag     2160

gcttcctttg ttttggagcg cttgaaggaa atggacgaaa aggaatttta tgcgtgcgaa     2220

atccagctgc aaaaatggta tggtgatttg agggggaacc ccttcgctgt ggaagccgaa     2280

aaccgggtcg tggacatatc cgggttttcc atagggtcgg acggtcactc cattcaatac     2340

cggaatttgc ttgcatggaa atatcttgag aacggtaagc gggagtttta tttgctgatg     2400

aactacggaa aaaagggtcg cattaggttc actgatggca cagatattaa aaaaagcggt     2460

aagtggcaag gtcttctgta cggcggagga aaggcgaagg ttatcgactt gacctttgac     2520

ccagacgatg agcagttgat tattttgcct ttggcattcg gtacaagaca agggagggaa     2580

ttcatctgga acgatctgct ctcccttgaa acgggtctca tcaagctggc taacggcaga     2640

gtcatagaga aaaccatata taataagaag attggtagag atgagccggc tctttttgtg     2700

gcgctcactt tcgagaggcg cgaggtcgtt gacccgtcca acatcaagcc cgttaacctg     2760

atcggtgttg ataggggaga aaacataccg gcggtgatag cacttaccga cccagaggga     2820

tgccccctcc cagaattcaa agattcttcg gggggaccaa ctgacattct caggataggt     2880

gagggctata aggagaagca gcgcgctatc caagcggcga aggaagtcga gcaacggaga     2940

gcggggggct attctcggaa attcgcatcg aaaagccgga atcttgccga cgacatggtc     3000

aggaactcag ccagggacct cttctatcac gcggttacgc acgacgccgt tcttgttttt     3060

gaaaatctct cgcggggttt tggacggcaa ggtaagcgga cctttatgac ggaaagacag     3120

tacaccaaaa tggaagattg gctcaccgcg aagctcgcgt acgaggggct tacatctaaa     3180

acgtacttgt ccaaaacact cgcccagtac actagcaaaa cgtgttctaa ctgcggcttt     3240

acgatcacta ccgcggacta cgacggcatg ctcgtcaggc tcaagaaaac gtctgacgga     3300

tgggcaacca cacttaacaa taaagagctc aaggctgaag gtcagatcac atattataat     3360

agatataaga ggcagaccgt ggagaaggag ctgtcagctg agcttgacag gttgtctgag     3420

gagtccggca acaacgatat ttctaagtgg acaaaaggac ggagagatga agcattgttt     3480

ctgctcaaaa agcggttctc gcacaggccc gttcaggagc agtttgtttg tcttgattgc     3540

ggtcacgagg tccacgcgga tgagcaggcc gctctcaata tagcgaggag ctggttgttt     3600

ttgaactcta attccacaga attcaaaagc tataagtccg ggaagcaacc gttcgtgggc     3660

gcttggcaag ccttttataa gcgcaggctc aaggaggttt ggaaaccaaa cgctaaacgc     3720

cccgcggcta caaagaaggc tggccaggca aagaagaaga agaccaacct gtccgacatc     3780

atcgagaagg aaacgggcaa gcaactcgtg atccaggaga gcatcctcat gctgccagag     3840

gaggtggagg aggtcatcgg caacaagcca gagtccgaca tcctggtgca caccgcctac     3900

gacgagtcca ccgacgagaa cgtcatgctc ctgaccagcg acgccccaga gtacaagcca     3960

tgggccctcg tcatccagga cagcaacggg gagaacaaga tcaagatgct gtcggggggg     4020

agcccaaaga agaagcggaa ggtgtag                                         4047


<210>  15
<211>  4962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APOBEC1 XTEN linker AsCpf1(R1226A) UGI NLS codon optimized

<400>  15
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggaaacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgaa      720

acgccaggca cctccgagag cgctacgcct gaacttaaga cccaatttga gggatttacg      780

aatctttatc aagtttcaaa gacgcttagg tttgagctca ttccacaagg aaaaaccttg      840

aagcacattc aagagcaggg ctttatcgag gaagacaagg cacggaatga ccattataaa      900

gaattgaaac ccataatcga tcgcatatac aaaacttatg ccgaccaatg cttgcagctt      960

gtccaactcg actgggaaaa tctctcggct gcgatagact cttacaggaa ggaaaagaca     1020

gaagaaacaa gaaacgccct cattgaagag caggctacgt atagaaatgc tattcacgac     1080

tatttcattg gcagaacaga taacttgacg gacgccataa acaaaagaca tgcggagatc     1140

tacaagggat tgttcaaagc ggagcttttc aacggaaaag ttctcaagca gcttggcacg     1200

gtcaccacta ccgaacacga aaacgccttg ttgaggagct tcgataagtt cacgacatat     1260

ttctctggtt tctatgagaa tcggaagaat gtcttctctg cagaagacat ttcaaccgca     1320

atcccacacc ggattgtgca agataacttt ccgaaattta aggaaaactg tcacatcttc     1380

actaggttga ttacggctgt tccatctctt agagaacact tcgaaaacgt caaaaaagct     1440

ataggcattt tcgtctcaac gagcatagag gaggtcttct cgttcccttt ctataaccag     1500

cttctcaccc agacacagat tgatctctat aatcaactcc ttggtggtat ttcaagggaa     1560

gccgggacgg agaagattaa ggggttgaat gaagttctca atctggcgat acagaagaat     1620

gacgaaaccg cccatattat agcttccctc ccacatcggt ttataccgtt gttcaagcag     1680

atcctgtcgg accgcaacac gctttctttc atactcgaag agttcaaaag cgacgaggaa     1740

gtcatacaga gcttctgtaa gtataaaaca cttttgagga atgaaaacgt tcttgaaact     1800

gccgaggcct tgtttaacga gctcaacagc atagatctta cgcatatttt tatttcccac     1860

aaaaaattgg aaactataag ctcagcgctg tgtgatcact gggatacgct tcgcaatgcc     1920

ctttatgagc gcaggatcag cgaactgacg gggaagatta cgaaatctgc gaaagagaaa     1980

gttcaaaggt cccttaagca cgaggatatt aatctccaag aaataataag cgcggctggt     2040

aaagaacttt ccgaagcttt caagcaaaag acatccgaaa tactctccca tgcgcatgca     2100

gccctggacc aaccattgcc aacaactttg aagaaacaag aagagaagga aatcctgaag     2160

tcccaactcg actctttgct cggcctctat cacttgcttg attggttcgc ggttgatgag     2220

tccaacgaag ttgaccctga gttcagcgcc aggttgaccg gtataaagtt ggaaatggaa     2280

ccaagcctct cattttacaa caaggcgagg aactacgcga ccaagaaacc atacagcgtc     2340

gaaaagttta agcttaactt tcaaatgcca acgctcgctt ccggttggga tgttaacaaa     2400

gaaaaaaata acggcgccat cttgtttgtt aaaaacggtt tgtattacct cggcatcatg     2460

ccaaaacaaa agggtcggta caaggctctg agcttcgagc caacagagaa aacaagcgaa     2520

ggcttcgaca agatgtatta tgattacttt cccgatgcag ctaaaatgat ccccaagtgc     2580

tcaacacagc ttaaagcggt taccgcccat ttccagactc acacgacccc aattctcttg     2640

tcaaataact ttattgaacc cttggaaata accaaagaga tatatgacct taataacccg     2700

gagaaagaac ccaagaagtt ccagacggcg tacgctaaga aaacaggaga tcagaagggc     2760

tatagggagg ccctttgtaa atggattgac tttacaaggg actttttgtc gaaatatacg     2820

aagaccactt caattgacct ttcgtccctg cggccgtcta gccagtataa agatttgggt     2880

gagtactatg cggaacttaa tcctttgttg taccacatat cttttcaacg gattgcagag     2940

aaggagataa tggatgcggt cgaaacagga aagctctatc tgttccagat ttacaataaa     3000

gattttgcca agggacacca tggaaaacct aacctgcata ctctttactg gacgggtctt     3060

ttctcgccgg aaaatttggc taagacgtct atcaagttga atgggcaggc agaactcttc     3120

tatcgcccta agtctaggat gaaacggatg gctcatcggc tgggtgaaaa aatgctcaac     3180

aaaaagctta aggatcaaaa gacaccaatc ccggacacac tttatcaaga attgtacgat     3240

tacgttaatc acagactctc acatgacctt tcagatgagg cccgcgcttt gcttcccaat     3300

gttattacta aagaggtctc gcatgagatc ataaaagata gaagattcac gtctgataag     3360

ttcttttttc atgtgccaat aactctcaac tatcaggccg caaattcgcc gtccaagttc     3420

aaccaaaggg tgaatgccta cctcaaggag cacccggaga cgccaataat aggtatcgat     3480

cggggcgaac gcaaccttat ttatataaca gttatcgata gcacagggaa aatactggag     3540

cagcggagcc tgaatactat tcaacagttt gactaccaaa agaaactgga caatagagag     3600

aaggagcgcg tcgccgcccg gcaagcttgg tccgtggtcg gaactataaa agatcttaaa     3660

cagggatacc tgtcacaggt catccatgaa atcgtggatc tgatgataca ctatcaagct     3720

gttgtcgtgc tcgaaaactt gaattttgga ttcaaatcga agagaactgg aatcgctgaa     3780

aaagcggtgt accaacagtt cgagaagatg ctcatcgata agcttaattg tttggtgctt     3840

aaggactatc ccgccgaaaa ggttgggggg gtgctgaacc cgtatcagct cacagatcaa     3900

tttacttcat tcgcgaagat gggaacgcag tcaggatttc tgttctacgt tccagcccct     3960

tatacgtcga aaattgaccc tcttacgggg ttcgtggacc cctttgtttg gaaaacgata     4020

aaaaaccacg agtcacgcaa gcactttctc gagggatttg attttcttca ttatgatgtg     4080

aagaccgggg acttcatttt gcactttaag atgaacagga acttgtcttt ccaaaggggc     4140

ttgcctggat tcatgccggc ctgggatatc gtgtttgaaa agaacgaaac acagttcgat     4200

gcgaaaggga cgcccttcat agctggaaag cgcatagttc cagtgattga gaaccacaga     4260

ttcactggtc gctacagaga cctgtatccg gcaaatgaac tgatagcact ccttgaggaa     4320

aagggtatcg tgtttcgcga tggttcaaat attctcccga agcttttgga gaacgacgat     4380

tctcatgcta tagatactat ggtcgctctc atccggtccg tccttcaaat ggccaattcg     4440

aatgcagcga ccggtgagga ttacataaat tcaccagtcc gggaccttaa tggggtttgc     4500

ttcgactcgc gctttcaaaa ccccgaatgg ccaatggacg ccgatgctaa cggtgcctac     4560

catatagcac ttaaaggaca gcttctgttg aatcacctta aagaatcaaa agaccttaag     4620

ctgcagaatg gaatttcaaa tcaggattgg ctcgcgtaca tacaggagct tcgcaatacc     4680

aacctgtccg acatcatcga gaaggaaacg ggcaagcaac tcgtgatcca ggagagcatc     4740

ctcatgctgc cagaggaggt ggaggaggtc atcggcaaca agccagagtc cgacatcctg     4800

gtgcacaccg cctacgacga gtccaccgac gagaacgtca tgctcctgac cagcgacgcc     4860

ccagagtaca agccatgggc cctcgtcatc caggacagca acggggagaa caagatcaag     4920

atgctgtcgg gggggagccc aaagaagaag cggaaggtgt ag                        4962


<210>  16
<211>  5121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLS dCas9 NLS Linker PmCDA1 UGI construct

<400>  16
atgccaaaga agaagaggaa ggttgacaag aagtactcga tcggcctcgc catcgggacg       60

aactcagttg gctgggccgt gatcaccgac gagtacaagg tgccctctaa gaagttcaag      120

gtcctgggga acaccgaccg ccattccatc aagaagaacc tcatcggcgc tctcctgttc      180

gacagcgggg agaccgctga ggctacgagg ctcaagagaa ccgctaggcg ccggtacacg      240

agaaggaaga acaggatctg ctacctccaa gagattttct ccaacgagat ggccaaggtt      300

gacgattcat tcttccaccg cctggaggag tctttcctcg tggaggagga taagaagcac      360

gagcggcatc ccatcttcgg caacatcgtg gacgaggttg cctaccacga gaagtaccct      420

acgatctacc atctgcggaa gaagctcgtg gactccaccg ataaggcgga cctcagactg      480

atctacctcg ctctggccca catgatcaag ttccgcggcc atttcctgat cgagggggat      540

ctcaacccag acaacagcga tgttgacaag ctgttcatcc aactcgtgca gacctacaac      600

caactcttcg aggagaaccc gatcaacgcc tctggcgtgg acgcgaaggc tatcctgtcc      660

gcgaggctct cgaagtccag gaggctggag aacctgatcg ctcagctccc aggcgagaag      720

aagaacggcc tgttcgggaa cctcatcgct ctcagcctgg ggctcacccc gaacttcaag      780

tcgaacttcg atctcgctga ggacgccaag ctgcaactct ccaaggacac ctacgacgat      840

gacctcgata acctcctggc ccagatcggc gatcaatacg cggacctgtt cctcgctgcc      900

aagaacctgt cggacgccat cctcctgtca gatatcctcc gcgtgaacac cgagatcacg      960

aaggctccac tctctgcctc catgatcaag cgctacgacg agcaccatca ggatctgacc     1020

ctcctgaagg cgctggtccg ccaacagctc ccggagaagt acaaggagat tttcttcgat     1080

cagtcgaaga acggctacgc tgggtacatc gacggcgggg cctcacaaga ggagttctac     1140

aagttcatca agccaatcct ggagaagatg gacggcacgg aggagctcct ggtgaagctc     1200

aacagggagg acctcctgcg gaagcagaga accttcgata acggcagcat cccccaccaa     1260

atccatctcg gggagctgca cgccatcctg agaaggcaag aggacttcta ccctttcctc     1320

aaggataacc gggagaagat cgagaagatc ctgaccttca gaatcccata ctacgtcggc     1380

cctctcgcgc gggggaactc aagattcgct tggatgaccc gcaagtctga ggagaccatc     1440

acgccgtgga acttcgagga ggtggtggac aagggcgcta gcgctcagtc gttcatcgag     1500

aggatgacca acttcgacaa gaacctgccc aacgagaagg tgctccctaa gcactcgctc     1560

ctgtacgagt acttcaccgt ctacaacgag ctcacgaagg tgaagtacgt caccgagggc     1620

atgcgcaagc cagcgttcct gtccggggag cagaagaagg ctatcgtgga cctcctgttc     1680

aagaccaacc ggaaggtcac ggttaagcaa ctcaaggagg actacttcaa gaagatcgag     1740

tgcttcgatt cggtcgagat cagcggcgtt gaggaccgct tcaacgccag cctcgggacc     1800

taccacgatc tcctgaagat catcaaggat aaggacttcc tggacaacga ggagaacgag     1860

gatatcctgg aggacatcgt gctgaccctc acgctgttcg aggacaggga gatgatcgag     1920

gagcgcctga agacgtacgc ccatctcttc gatgacaagg tcatgaagca actcaagcgc     1980

cggagataca ccggctgggg gaggctgtcc cgcaagctca tcaacggcat ccgggacaag     2040

cagtccggga agaccatcct cgacttcctc aagagcgatg gcttcgccaa caggaacttc     2100

atgcaactga tccacgatga cagcctcacc ttcaaggagg atatccaaaa ggctcaagtg     2160

agcggccagg gggactcgct gcacgagcat atcgcgaacc tcgctggctc ccccgcgatc     2220

aagaagggca tcctccagac cgtgaaggtt gtggacgagc tcgtgaaggt catgggccgg     2280

cacaagcctg agaacatcgt catcgagatg gccagagaga accaaaccac gcagaagggg     2340

caaaagaact ctagggagcg catgaagcgc atcgaggagg gcatcaagga gctggggtcc     2400

caaatcctca aggagcaccc agtggagaac acccaactgc agaacgagaa gctctacctg     2460

tactacctcc agaacggcag ggatatgtac gtggaccaag agctggatat caaccgcctc     2520

agcgattacg atgtcgatca tatcgttccc cagtctttcc tgaaggatga ctccatcgac     2580

aacaaggtcc tcaccaggtc ggacaagaac cgcggcaagt cagataacgt tccatctgag     2640

gaggtcgtta agaagatgaa gaactactgg aggcagctcc tgaacgccaa gctgatcacg     2700

caaaggaagt tcgacaacct caccaaggct gagagaggcg ggctctcaga gctggacaag     2760

gccggcttca tcaagcggca gctggtcgag accagacaaa tcacgaagca cgttgcgcaa     2820

atcctcgact ctcggatgaa cacgaagtac gatgagaacg acaagctgat cagggaggtt     2880

aaggtgatca ccctgaagtc taagctcgtt tccgacttca ggaaggattt ccagttctac     2940

aaggttcgcg agatcaacaa ctaccaccat gcccatgacg cttacctcaa cgctgtggtc     3000

ggcaccgctc tgatcaagaa gtacccaaag ctggagtccg agttcgtgta cggggactac     3060

aaggtttacg atgtgcgcaa gatgatcgcc aagtcggagc aagagatcgg caaggctacc     3120

gccaagtact tcttctactc aaacatcatg aacttcttca agaccgagat cacgctggcc     3180

aacggcgaga tccggaagag accgctcatc gagaccaacg gcgaaacggg ggagatcgtg     3240

tgggacaagg gcagggattt cgcgaccgtc cgcaaggttc tctccatgcc ccaggtgaac     3300

atcgtcaaga agaccgaggt ccaaacgggc gggttctcaa aggagtctat cctgcctaag     3360

cggaacagcg acaagctcat cgccagaaag aaggactggg acccaaagaa gtacggcggg     3420

ttcgacagcc ctaccgtggc ctactcggtc ctggttgtgg cgaaggttga gaagggcaag     3480

tccaagaagc tcaagagcgt gaaggagctc ctggggatca ccatcatgga gaggtccagc     3540

ttcgagaaga acccaatcga cttcctggag gccaagggct acaaggaggt gaagaaggac     3600

ctgatcatca agctcccgaa gtactctctc ttcgagctgg agaacggcag gaagagaatg     3660

ctggcttccg ctggcgagct ccagaagggg aacgagctcg cgctgccaag caagtacgtg     3720

aacttcctct acctggcttc ccactacgag aagctcaagg gcagcccgga ggacaacgag     3780

caaaagcagc tgttcgtcga gcagcacaag cattacctcg acgagatcat cgagcaaatc     3840

tccgagttca gcaagcgcgt gatcctcgcc gacgcgaacc tggataaggt cctctccgcc     3900

tacaacaagc accgggacaa gcccatcaga gagcaagcgg agaacatcat ccatctcttc     3960

accctgacga acctcggcgc tcctgctgct ttcaagtact tcgacaccac gatcgatcgg     4020

aagagataca cctccacgaa ggaggtcctg gacgcgaccc tcatccacca gtcgatcacc     4080

ggcctgtacg aaacgaggat cgacctctca caactcggcg gggataagag acccgcagca     4140

accaagaagg cagggcaagc aaagaagaag aagacgcgtg actccggcgg cagcccaaag     4200

aagaagagga aggttggtgg aggaggttct ggaggtggag gttctatgac cgacgctgag     4260

tacgtgagaa tccatgagaa gttggacatc tacacgttta agaaacagtt tttcaacaac     4320

aaaaaatccg tgtcgcatag atgctacgtt ctctttgaat taaaacgacg gggtgaacgt     4380

agagcgtgtt tttggggcta tgctgtgaat aaaccacaga gcgggacaga acgtggcatt     4440

cacgccgaaa tctttagcat tagaaaagtc gaagaatacc tgcgcgacaa ccccggacaa     4500

ttcacgataa attggtactc atcctggagt ccttgtgcag attgcgctga aaagatctta     4560

gaatggtata accaggagct gcgggggaac ggccacactt tgaaaatctg ggcttgcaaa     4620

ctctattacg agaaaaatgc gaggaatcaa attgggctgt ggaacctcag agataacggg     4680

gttgggttga atgtaatggt aagtgaacac taccaatgtt gcaggaaaat attcatccaa     4740

tcgtcgcaca atcaattgaa tgagaataga tggcttgaga agactttgaa gcgagctgaa     4800

aaacgacgga gcgagttgtc cattatgatt caggtaaaaa tactccacac cactaagagt     4860

cctgctgtta ccaacctgtc cgacatcatc gagaaggaaa cgggcaagca actcgtgatc     4920

caggagagca tcctcatgct gccagaggag gtggaggagg tcatcggcaa caagccagag     4980

tccgacatcc tggtgcacac cgcctacgac gagtccaccg acgagaacgt catgctcctg     5040

accagcgacg ccccagagta caagccatgg gccctcgtca tccaggacag caacggggag     5100

aacaagatca agatgctgtg a                                               5121


<210>  17
<211>  4101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nCas9 (D10A)

<400>  17
gataaaaagt attctattgg tttagccatc ggcactaatt ccgttggatg ggctgtcata       60

accgatgaat acaaagtacc ttcaaagaaa tttaaggtgt tggggaacac agaccgtcat      120

tcgattaaaa agaatcttat cggtgccctc ctattcgata gtggcgaaac ggcagaggcg      180

actcgcctga aacgaaccgc tcggagaagg tatacacgtc gcaagaaccg aatatgttac      240

ttacaagaaa tttttagcaa tgagatggcc aaagttgacg attctttctt tcaccgtttg      300

gaagagtcct tccttgtcga agaggacaag aaacatgaac ggcaccccat ctttggaaac      360

atagtagatg aggtggcata tcatgaaaag tacccaacga tttatcacct cagaaaaaag      420

ctagttgact caactgataa agcggacctg aggttaatct acttggctct tgcccatatg      480

ataaagttcc gtgggcactt tctcattgag ggtgatctaa atccggacaa ctcggatgtc      540

gacaaactgt tcatccagtt agtacaaacc tataatcagt tgtttgaaga gaaccctata      600

aatgcaagtg gcgtggatgc gaaggctatt cttagcgccc gcctctctaa atcccgacgg      660

ctagaaaacc tgatcgcaca attacccgga gagaagaaaa atgggttgtt cggtaacctt      720

atagcgctct cactaggcct gacaccaaat tttaagtcga acttcgactt agctgaagat      780

gccaaattgc agcttagtaa ggacacgtac gatgacgatc tcgacaatct actggcacaa      840

attggagatc agtatgcgga cttatttttg gctgccaaaa accttagcga tgcaatcctc      900

ctatctgaca tactgagagt taatactgag attaccaagg cgccgttatc cgcttcaatg      960

atcaaaaggt acgatgaaca tcaccaagac ttgacacttc tcaaggccct agtccgtcag     1020

caactgcctg agaaatataa ggaaatattc tttgatcagt cgaaaaacgg gtacgcaggt     1080

tatattgacg gcggagcgag tcaagaggaa ttctacaagt ttatcaaacc catattagag     1140

aagatggatg ggacggaaga gttgcttgta aaactcaatc gcgaagatct actgcgaaag     1200

cagcggactt tcgacaacgg tagcattcca catcaaatcc acttaggcga attgcatgct     1260

atacttagaa ggcaggagga tttttatccg ttcctcaaag acaatcgtga aaagattgag     1320

aaaatcctaa cctttcgcat accttactat gtgggacccc tggcccgagg gaactctcgg     1380

ttcgcatgga tgacaagaaa gtccgaagaa acgattactc catggaattt tgaggaagtt     1440

gtcgataaag gtgcgtcagc tcaatcgttc atcgagagga tgaccaactt tgacaagaat     1500

ttaccgaacg aaaaagtatt gcctaagcac agtttacttt acgagtattt cacagtgtac     1560

aatgaactca cgaaagttaa gtatgtcact gagggcatgc gtaaacccgc ctttctaagc     1620

ggagaacaga agaaagcaat agtagatctg ttattcaaga ccaaccgcaa agtgacagtt     1680

aagcaattga aagaggacta ctttaagaaa attgaatgct tcgattctgt cgagatctcc     1740

ggggtagaag atcgatttaa tgcgtcactt ggtacgtatc atgacctcct aaagataatt     1800

aaagataagg acttcctgga taacgaagag aatgaagata tcttagaaga tatagtgttg     1860

actcttaccc tctttgaaga tcgggaaatg attgaggaaa gactaaaaac atacgctcac     1920

ctgttcgacg ataaggttat gaaacagtta aagaggcgtc gctatacggg ctggggacga     1980

ttgtcgcgga aacttatcaa cgggataaga gacaagcaaa gtggtaaaac tattctcgat     2040

tttctaaaga gcgacggctt cgccaatagg aactttatgc agctgatcca tgatgactct     2100

ttaaccttca aagaggatat acaaaaggca caggtttccg gacaagggga ctcattgcac     2160

gaacatattg cgaatcttgc tggttcgcca gccatcaaaa agggcatact ccagacagtc     2220

aaagtagtgg atgagctagt taaggtcatg ggacgtcaca aaccggaaaa cattgtaatc     2280

gagatggcac gcgaaaatca aacgactcag aaggggcaaa aaaacagtcg agagcggatg     2340

aagagaatag aagagggtat taaagaactg ggcagccaga tcttaaagga gcatcctgtg     2400

gaaaataccc aattgcagaa cgagaaactt tacctctatt acctacaaaa tggaagggac     2460

atgtatgttg atcaggaact ggacataaac cgtttatctg attacgacgt cgatcacatt     2520

gtaccccaat cctttttgaa ggacgattca atcgacaata aagtgcttac acgctcggat     2580

aagaaccgag ggaaaagtga caatgttcca agcgaggaag tcgtaaagaa aatgaagaac     2640

tattggcggc agctcctaaa tgcgaaactg ataacgcaaa gaaagttcga taacttaact     2700

aaagctgaga ggggtggctt gtctgaactt gacaaggccg gatttattaa acgtcagctc     2760

gtggaaaccc gccaaatcac aaagcatgtt gcacagatac tagattcccg aatgaatacg     2820

aaatacgacg agaacgataa gctgattcgg gaagtcaaag taatcacttt aaagtcaaaa     2880

ttggtgtcgg acttcagaaa ggattttcaa ttctataaag ttagggagat aaataactac     2940

caccatgcgc acgacgctta tcttaatgcc gtcgtaggga ccgcactcat taagaaatac     3000

ccgaagctag aaagtgagtt tgtgtatggt gattacaaag tttatgacgt ccgtaagatg     3060

atcgcgaaaa gcgaacagga gataggcaag gctacagcca aatacttctt ttattctaac     3120

attatgaatt tctttaagac ggaaatcact ctggcaaacg gagagatacg caaacgacct     3180

ttaattgaaa ccaatgggga gacaggtgaa atcgtatggg ataagggccg ggacttcgcg     3240

acggtgagaa aagttttgtc catgccccaa gtcaacatag taaagaaaac tgaggtgcag     3300

accggagggt tttcaaagga atcgattctt ccaaaaagga atagtgataa gctcatcgct     3360

cgtaaaaagg actgggaccc gaaaaagtac ggtggcttcg atagccctac agttgcctat     3420

tctgtcctag tagtggcaaa agttgagaag ggaaaatcca agaaactgaa gtcagtcaaa     3480

gaattattgg ggataacgat tatggagcgc tcgtcttttg aaaagaaccc catcgacttc     3540

cttgaggcga aaggttacaa ggaagtaaaa aaggatctca taattaaact accaaagtat     3600

agtctgtttg agttagaaaa tggccgaaaa cggatgttgg ctagcgccgg agagcttcaa     3660

aaggggaacg aactcgcact accgtctaaa tacgtgaatt tcctgtattt agcgtcccat     3720

tacgagaagt tgaaaggttc acctgaagat aacgaacaga agcaactttt tgttgagcag     3780

cacaaacatt atctcgacga aatcatagag caaatttcgg aattcagtaa gagagtcatc     3840

ctagctgatg ccaatctgga caaagtatta agcgcataca acaagcacag ggataaaccc     3900

atacgtgagc aggcggaaaa tattatccat ttgtttactc ttaccaacct cggcgctcca     3960

gccgcattca agtattttga cacaacgata gatcgcaaac gatacacttc taccaaggag     4020

gtgctagacg cgacactgat tcaccaatcc atcacgggat tatatgaaac tcggatagat     4080

ttgtcacagc ttgggggtga c                                               4101


<210>  18
<211>  3003
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX

<400>  18
gagaagagaa ttaacaagat cagaaaaaaa ttgagcgccg acaatgcgac taaaccagtt       60

tccagaagcg gccctatgaa aacgctcctc gtgcgggtca tgacagatga ccttaaaaaa      120

cgccttgaga agcgcagaaa gaaaccggaa gtgatgcctc aagttatttc caataatgcc      180

gccaataacc tccgcatgct tttggatgac tacaccaaaa tgaaggaagc gatacttcaa      240

gtttactggc aagagttcaa agatgatcac gttggtctta tgtgtaaatt tgcccaaccg      300

gcctctaaga agatagatca gaacaagctg aagccagaga tggacgagaa gggaaatctc      360

acgactgcgg gcttcgcgtg ctcgcaatgt ggtcagcctc tctttgtgta taaacttgag      420

caagtctcag agaaggggaa agcatatacg aactacttcg gtagatgcaa cgtggcagag      480

catgaaaaac ttattttgct cgctcagctg aaaccggaga aagactcgga cgaagcagtt      540

acttatagcc ttggcaaatt tggccaaagg gcactcgact tctatagcat ccacgtgacg      600

aaggaatcta cgcatccagt gaaaccattg gcgcagattg caggaaatcg ctatgcgtcg      660

ggaccggtgg gcaaggccct ttcggatgcc tgtatgggta cgatagcttc ctttttgtca      720

aagtaccaag atataattat cgaacaccaa aaggtcgtca aggggaatca aaagagattg      780

gaaagtttga gggagctcgc tggcaaggag aatctcgaat atccatcagt cacgctccct      840

ccgcagccac ataccaagga aggggttgac gcttataatg aggttatcgc gcgggtccgc      900

atgtgggtca acttgaatct ttggcaaaaa ctcaaactgt ccagagatga tgcaaagcct      960

ttgctcaggt tgaagggctt cccttcgttc ccagtcgttg aaaggagaga aaacgaagtc     1020

gattggtgga acactatcaa tgaagtgaaa aagctcattg atgctaagag agacatgggt     1080

agggtctttt ggtctggagt taccgcagaa aagcggaata ctattctgga aggctacaac     1140

tatcttccca acgaaaacga ccacaagaaa agggagggga gcctcgaaaa tcccaaaaaa     1200

ccggcgaaac gccaatttgg ggatctgctt ctttatctgg agaagaagta tgcaggcgac     1260

tggggaaaag tgtttgacga ggcttgggag cgcatcgaca aaaagatcgc tggcctcaca     1320

tcacacatag aaagggagga ggcaaggaat gcagaagatg cgcagagcaa agcagttctt     1380

acggattggt tgcgcgctaa ggcttccttt gttttggagc gcttgaagga aatggacgaa     1440

aaggaatttt atgcgtgcga aatccagctg caaaaatggt atggtgattt gagggggaac     1500

cccttcgctg tggaagccga aaaccgggtc gtggacatat ccgggttttc catagggtcg     1560

gacggtcact ccattcaata ccggaatttg cttgcatgga aatatcttga gaacggtaag     1620

cgggagtttt atttgctgat gaactacgga aaaaagggtc gcattaggtt cactgatggc     1680

acagatatta aaaaaagcgg taagtggcaa ggtcttctgt acggcggagg aaaggcgaag     1740

gttatcgact tgacctttga cccagacgat gagcagttga ttattttgcc tttggcattc     1800

ggtacaagac aagggaggga attcatctgg aacgatctgc tctcccttga aacgggtctc     1860

atcaagctgg ctaacggcag agtcatagag aaaaccatat ataataagaa gattggtaga     1920

gatgagccgg ctctttttgt ggcgctcact ttcgagaggc gcgaggtcgt tgacccgtcc     1980

aacatcaagc ccgttaacct gatcggtgtt gataggggag aaaacatacc ggcggtgata     2040

gcacttaccg acccagaggg atgccccctc ccagaattca aagattcttc ggggggacca     2100

actgacattc tcaggatagg tgagggctat aaggagaagc agcgcgctat ccaagcggcg     2160

aaggaagtcg agcaacggag agcggggggc tattctcgga aattcgcatc gaaaagccgg     2220

aatcttgccg acgacatggt caggaactca gccagggacc tcttctatca cgcggttacg     2280

cacgacgccg ttcttgtttt tgaaaatctc tcgcggggtt ttggacggca aggtaagcgg     2340

acctttatga cggaaagaca gtacaccaaa atggaagatt ggctcaccgc gaagctcgcg     2400

tacgaggggc ttacatctaa aacgtacttg tccaaaacac tcgcccagta cactagcaaa     2460

acgtgttcta actgcggctt tacgatcact accgcggact acgacggcat gctcgtcagg     2520

ctcaagaaaa cgtctgacgg atgggcaacc acacttaaca ataaagagct caaggctgaa     2580

ggtcagatca catattataa tagatataag aggcagaccg tggagaagga gctgtcagct     2640

gagcttgaca ggttgtctga ggagtccggc aacaacgata tttctaagtg gacaaaagga     2700

cggagagatg aagcattgtt tctgctcaaa aagcggttct cgcacaggcc cgttcaggag     2760

cagtttgttt gtcttgattg cggtcacgag gtccacgcgg atgagcaggc cgctctcaat     2820

atagcgagga gctggttgtt tttgaactct aattccacag aattcaaaag ctataagtcc     2880

gggaagcaac cgttcgtggg cgcttggcaa gccttttata agcgcaggct caaggaggtt     2940

tggaaaccaa acgctaaacg ccccgcggct acaaagaagg ctggccaggc aaagaagaag     3000

aag                                                                   3003


<210>  19
<211>  3918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AsCpf1 (R1226A)

<400>  19
acccaatttg agggatttac gaatctttat caagtttcaa agacgcttag gtttgagctc       60

attccacaag gaaaaacctt gaagcacatt caagagcagg gctttatcga ggaagacaag      120

gcacggaatg accattataa agaattgaaa cccataatcg atcgcatata caaaacttat      180

gccgaccaat gcttgcagct tgtccaactc gactgggaaa atctctcggc tgcgatagac      240

tcttacagga aggaaaagac agaagaaaca agaaacgccc tcattgaaga gcaggctacg      300

tatagaaatg ctattcacga ctatttcatt ggcagaacag ataacttgac ggacgccata      360

aacaaaagac atgcggagat ctacaaggga ttgttcaaag cggagctttt caacggaaaa      420

gttctcaagc agcttggcac ggtcaccact accgaacacg aaaacgcctt gttgaggagc      480

ttcgataagt tcacgacata tttctctggt ttctatgaga atcggaagaa tgtcttctct      540

gcagaagaca tttcaaccgc aatcccacac cggattgtgc aagataactt tccgaaattt      600

aaggaaaact gtcacatctt cactaggttg attacggctg ttccatctct tagagaacac      660

ttcgaaaacg tcaaaaaagc tataggcatt ttcgtctcaa cgagcataga ggaggtcttc      720

tcgttccctt tctataacca gcttctcacc cagacacaga ttgatctcta taatcaactc      780

cttggtggta tttcaaggga agccgggacg gagaagatta aggggttgaa tgaagttctc      840

aatctggcga tacagaagaa tgacgaaacc gcccatatta tagcttccct cccacatcgg      900

tttataccgt tgttcaagca gatcctgtcg gaccgcaaca cgctttcttt catactcgaa      960

gagttcaaaa gcgacgagga agtcatacag agcttctgta agtataaaac acttttgagg     1020

aatgaaaacg ttcttgaaac tgccgaggcc ttgtttaacg agctcaacag catagatctt     1080

acgcatattt ttatttccca caaaaaattg gaaactataa gctcagcgct gtgtgatcac     1140

tgggatacgc ttcgcaatgc cctttatgag cgcaggatca gcgaactgac ggggaagatt     1200

acgaaatctg cgaaagagaa agttcaaagg tcccttaagc acgaggatat taatctccaa     1260

gaaataataa gcgcggctgg taaagaactt tccgaagctt tcaagcaaaa gacatccgaa     1320

atactctccc atgcgcatgc agccctggac caaccattgc caacaacttt gaagaaacaa     1380

gaagagaagg aaatcctgaa gtcccaactc gactctttgc tcggcctcta tcacttgctt     1440

gattggttcg cggttgatga gtccaacgaa gttgaccctg agttcagcgc caggttgacc     1500

ggtataaagt tggaaatgga accaagcctc tcattttaca acaaggcgag gaactacgcg     1560

accaagaaac catacagcgt cgaaaagttt aagcttaact ttcaaatgcc aacgctcgct     1620

tccggttggg atgttaacaa agaaaaaaat aacggcgcca tcttgtttgt taaaaacggt     1680

ttgtattacc tcggcatcat gccaaaacaa aagggtcggt acaaggctct gagcttcgag     1740

ccaacagaga aaacaagcga aggcttcgac aagatgtatt atgattactt tcccgatgca     1800

gctaaaatga tccccaagtg ctcaacacag cttaaagcgg ttaccgccca tttccagact     1860

cacacgaccc caattctctt gtcaaataac tttattgaac ccttggaaat aaccaaagag     1920

atatatgacc ttaataaccc ggagaaagaa cccaagaagt tccagacggc gtacgctaag     1980

aaaacaggag atcagaaggg ctatagggag gccctttgta aatggattga ctttacaagg     2040

gactttttgt cgaaatatac gaagaccact tcaattgacc tttcgtccct gcggccgtct     2100

agccagtata aagatttggg tgagtactat gcggaactta atcctttgtt gtaccacata     2160

tcttttcaac ggattgcaga gaaggagata atggatgcgg tcgaaacagg aaagctctat     2220

ctgttccaga tttacaataa agattttgcc aagggacacc atggaaaacc taacctgcat     2280

actctttact ggacgggtct tttctcgccg gaaaatttgg ctaagacgtc tatcaagttg     2340

aatgggcagg cagaactctt ctatcgccct aagtctagga tgaaacggat ggctcatcgg     2400

ctgggtgaaa aaatgctcaa caaaaagctt aaggatcaaa agacaccaat cccggacaca     2460

ctttatcaag aattgtacga ttacgttaat cacagactct cacatgacct ttcagatgag     2520

gcccgcgctt tgcttcccaa tgttattact aaagaggtct cgcatgagat cataaaagat     2580

agaagattca cgtctgataa gttctttttt catgtgccaa taactctcaa ctatcaggcc     2640

gcaaattcgc cgtccaagtt caaccaaagg gtgaatgcct acctcaagga gcacccggag     2700

acgccaataa taggtatcga tcggggcgaa cgcaacctta tttatataac agttatcgat     2760

agcacaggga aaatactgga gcagcggagc ctgaatacta ttcaacagtt tgactaccaa     2820

aagaaactgg acaatagaga gaaggagcgc gtcgccgccc ggcaagcttg gtccgtggtc     2880

ggaactataa aagatcttaa acagggatac ctgtcacagg tcatccatga aatcgtggat     2940

ctgatgatac actatcaagc tgttgtcgtg ctcgaaaact tgaattttgg attcaaatcg     3000

aagagaactg gaatcgctga aaaagcggtg taccaacagt tcgagaagat gctcatcgat     3060

aagcttaatt gtttggtgct taaggactat cccgccgaaa aggttggggg ggtgctgaac     3120

ccgtatcagc tcacagatca atttacttca ttcgcgaaga tgggaacgca gtcaggattt     3180

ctgttctacg ttccagcccc ttatacgtcg aaaattgacc ctcttacggg gttcgtggac     3240

ccctttgttt ggaaaacgat aaaaaaccac gagtcacgca agcactttct cgagggattt     3300

gattttcttc attatgatgt gaagaccggg gacttcattt tgcactttaa gatgaacagg     3360

aacttgtctt tccaaagggg cttgcctgga ttcatgccgg cctgggatat cgtgtttgaa     3420

aagaacgaaa cacagttcga tgcgaaaggg acgcccttca tagctggaaa gcgcatagtt     3480

ccagtgattg agaaccacag attcactggt cgctacagag acctgtatcc ggcaaatgaa     3540

ctgatagcac tccttgagga aaagggtatc gtgtttcgcg atggttcaaa tattctcccg     3600

aagcttttgg agaacgacga ttctcatgct atagatacta tggtcgctct catccggtcc     3660

gtccttcaaa tggccaattc gaatgcagcg accggtgagg attacataaa ttcaccagtc     3720

cgggacctta atggggtttg cttcgactcg cgctttcaaa accccgaatg gccaatggac     3780

gccgatgcta acggtgccta ccatatagca cttaaaggac agcttctgtt gaatcacctt     3840

aaagaatcaa aagaccttaa gctgcagaat ggaatttcaa atcaggattg gctcgcgtac     3900

atacaggagc ttcgcaat                                                   3918


<210>  20
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APOBEC1

<400>  20
atgagctcag agactggccc agtggctgtg gaccccacat tgagacggcg gatcgagccc       60

catgagtttg aggtattctt cgatccgaga gagctccgca aggagacctg cctgctttac      120

gaaattaatt gggggggccg gcactccatt tggcgacata catcacagaa cactaacaag      180

cacgtcgaag tcaacttcat cgagaagttc acgacagaaa gatatttctg tccgaacaca      240

aggtgcagca ttacctggtt tctcagctgg agcccatgcg gcgaatgtag tagggccatc      300

actgaattcc tgtcaaggta tccccacgtc actctgttta tttacatcgc aaggctgtac      360

caccacgctg acccccgcaa tcgacaaggc ctgcgggatt tgatctcttc aggtgtgact      420

atccaaatta tgactgagca ggagtcagga tactgctgga gaaactttgt gaattatagc      480

ccgagtaatg aagcccactg gcctaggtat ccccatctgt gggtacgact gtacgttctt      540

gaactgtact gcatcatact gggcctgcct ccttgtctca acattctgag aaggaagcag      600

ccacagctga cattctttac catcgctctt cagtcttgtc attaccagcg actgccccca      660

cacattctct gggccaccgg gttgaaa                                          687


<210>  21
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UGI

<400>  21
accaacctgt ccgacatcat cgagaaggaa acgggcaagc aactcgtgat ccaggagagc       60

atcctcatgc tgccagagga ggtggaggag gtcatcggca acaagccaga gtccgacatc      120

ctggtgcaca ccgcctacga cgagtccacc gacgagaacg tcatgctcct gaccagcgac      180

gccccagagt acaagccatg ggccctcgtc atccaggaca gcaacgggga gaacaagatc      240

aagatgctg                                                              249


<210>  22
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PmCDA1

<400>  22
atgaccgacg ctgagtacgt gagaatccat gagaagttgg acatctacac gtttaagaaa       60

cagtttttca acaacaaaaa atccgtgtcg catagatgct acgttctctt tgaattaaaa      120

cgacggggtg aacgtagagc gtgtttttgg ggctatgctg tgaataaacc acagagcggg      180

acagaacgtg gcattcacgc cgaaatcttt agcattagaa aagtcgaaga atacctgcgc      240

gacaaccccg gacaattcac gataaattgg tactcatcct ggagtccttg tgcagattgc      300

gctgaaaaga tcttagaatg gtataaccag gagctgcggg ggaacggcca cactttgaaa      360

atctgggctt gcaaactcta ttacgagaaa aatgcgagga atcaaattgg gctgtggaac      420

ctcagagata acggggttgg gttgaatgta atggtaagtg aacactacca atgttgcagg      480

aaaatattca tccaatcgtc gcacaatcaa ttgaatgaga atagatggct tgagaagact      540

ttgaagcgag ctgaaaaacg acggagcgag ttgtccatta tgattcaggt aaaaatactc      600

cacaccacta agagtcctgc tgtt                                             624


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer sequence

<400>  23
tgttacttct aaactacata                                                   20


<210>  24
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp. BV3L6

<400>  24

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  25
<211>  670
<212>  PRT
<213>  Arabidopsis thaliana

<400>  25

Met Ala Ala Ala Thr Thr Thr Thr Thr Thr Ser Ser Ser Ile Ser Phe 
1               5                   10                  15      


Ser Thr Lys Pro Ser Pro Ser Ser Ser Lys Ser Pro Leu Pro Ile Ser 
            20                  25                  30          


Arg Phe Ser Leu Pro Phe Ser Leu Asn Pro Asn Lys Ser Ser Ser Ser 
        35                  40                  45              


Ser Arg Arg Arg Gly Ile Lys Ser Ser Ser Pro Ser Ser Ile Ser Ala 
    50                  55                  60                  


Val Leu Asn Thr Thr Thr Asn Val Thr Thr Thr Pro Ser Pro Thr Lys 
65                  70                  75                  80  


Pro Thr Lys Pro Glu Thr Phe Ile Ser Arg Phe Ala Pro Asp Gln Pro 
                85                  90                  95      


Arg Lys Gly Ala Asp Ile Leu Val Glu Ala Leu Glu Arg Gln Gly Val 
            100                 105                 110         


Glu Thr Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu Ile His Gln 
        115                 120                 125             


Ala Leu Thr Arg Ser Ser Ser Ile Arg Asn Val Leu Pro Arg His Glu 
    130                 135                 140                 


Gln Gly Gly Val Phe Ala Ala Glu Gly Tyr Ala Arg Ser Ser Gly Lys 
145                 150                 155                 160 


Pro Gly Ile Cys Ile Ala Thr Ser Gly Pro Gly Ala Thr Asn Leu Val 
                165                 170                 175     


Ser Gly Leu Ala Asp Ala Leu Leu Asp Ser Val Pro Leu Val Ala Ile 
            180                 185                 190         


Thr Gly Gln Val Pro Arg Arg Met Ile Gly Thr Asp Ala Phe Gln Glu 
        195                 200                 205             


Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His Asn Tyr Leu 
    210                 215                 220                 


Val Met Asp Val Glu Asp Ile Pro Arg Ile Ile Glu Glu Ala Phe Phe 
225                 230                 235                 240 


Leu Ala Thr Ser Gly Arg Pro Gly Pro Val Leu Val Asp Val Pro Lys 
                245                 250                 255     


Asp Ile Gln Gln Gln Leu Ala Ile Pro Asn Trp Glu Gln Ala Met Arg 
            260                 265                 270         


Leu Pro Gly Tyr Met Ser Arg Met Pro Lys Pro Pro Glu Asp Ser His 
        275                 280                 285             


Leu Glu Gln Ile Val Arg Leu Ile Ser Glu Ser Lys Lys Pro Val Leu 
    290                 295                 300                 


Tyr Val Gly Gly Gly Cys Leu Asn Ser Ser Asp Glu Leu Gly Arg Phe 
305                 310                 315                 320 


Val Glu Leu Thr Gly Ile Pro Val Ala Ser Thr Leu Met Gly Leu Gly 
                325                 330                 335     


Ser Tyr Pro Cys Asp Asp Glu Leu Ser Leu His Met Leu Gly Met His 
            340                 345                 350         


Gly Thr Val Tyr Ala Asn Tyr Ala Val Glu His Ser Asp Leu Leu Leu 
        355                 360                 365             


Ala Phe Gly Val Arg Phe Asp Asp Arg Val Thr Gly Lys Leu Glu Ala 
    370                 375                 380                 


Phe Ala Ser Arg Ala Lys Ile Val His Ile Asp Ile Asp Ser Ala Glu 
385                 390                 395                 400 


Ile Gly Lys Asn Lys Thr Pro His Val Ser Val Cys Gly Asp Val Lys 
                405                 410                 415     


Leu Ala Leu Gln Gly Met Asn Lys Val Leu Glu Asn Arg Ala Glu Glu 
            420                 425                 430         


Leu Lys Leu Asp Phe Gly Val Trp Arg Asn Glu Leu Asn Val Gln Lys 
        435                 440                 445             


Gln Lys Phe Pro Leu Ser Phe Lys Thr Phe Gly Glu Ala Ile Pro Pro 
    450                 455                 460                 


Gln Tyr Ala Ile Lys Val Leu Asp Glu Leu Thr Asp Gly Lys Ala Ile 
465                 470                 475                 480 


Ile Ser Thr Gly Val Gly Gln His Gln Met Trp Ala Ala Gln Phe Tyr 
                485                 490                 495     


Asn Tyr Lys Lys Pro Arg Gln Trp Leu Ser Ser Gly Gly Leu Gly Ala 
            500                 505                 510         


Met Gly Phe Gly Leu Pro Ala Ala Ile Gly Ala Ser Val Ala Asn Pro 
        515                 520                 525             


Asp Ala Ile Val Val Asp Ile Asp Gly Asp Gly Ser Phe Ile Met Asn 
    530                 535                 540                 


Val Gln Glu Leu Ala Thr Ile Arg Val Glu Asn Leu Pro Val Lys Val 
545                 550                 555                 560 


Leu Leu Leu Asn Asn Gln His Leu Gly Met Val Met Gln Trp Glu Asp 
                565                 570                 575     


Arg Phe Tyr Lys Ala Asn Arg Ala His Thr Phe Leu Gly Asp Pro Ala 
            580                 585                 590         


Gln Glu Asp Glu Ile Phe Pro Asn Met Leu Leu Phe Ala Ala Ala Cys 
        595                 600                 605             


Gly Ile Pro Ala Ala Arg Val Thr Lys Lys Ala Asp Leu Arg Glu Ala 
    610                 615                 620                 


Ile Gln Thr Met Leu Asp Thr Pro Gly Pro Tyr Leu Leu Asp Val Ile 
625                 630                 635                 640 


Cys Pro His Gln Glu His Val Leu Pro Met Ile Pro Ser Gly Gly Thr 
                645                 650                 655     


Phe Asn Asp Val Ile Thr Glu Gly Asp Gly Arg Ile Lys Tyr 
            660                 665                 670 


<210>  26
<211>  537
<212>  PRT
<213>  Arabidopsis thaliana

<400>  26

Met Glu Leu Ser Leu Leu Arg Pro Thr Thr Gln Ser Leu Leu Pro Ser 
1               5                   10                  15      


Phe Ser Lys Pro Asn Leu Arg Leu Asn Val Tyr Lys Pro Leu Arg Leu 
            20                  25                  30          


Arg Cys Ser Val Ala Gly Gly Pro Thr Val Gly Ser Ser Lys Ile Glu 
        35                  40                  45              


Gly Gly Gly Gly Thr Thr Ile Thr Thr Asp Cys Val Ile Val Gly Gly 
    50                  55                  60                  


Gly Ile Ser Gly Leu Cys Ile Ala Gln Ala Leu Ala Thr Lys His Pro 
65                  70                  75                  80  


Asp Ala Ala Pro Asn Leu Ile Val Thr Glu Ala Lys Asp Arg Val Gly 
                85                  90                  95      


Gly Asn Ile Ile Thr Arg Glu Glu Asn Gly Phe Leu Trp Glu Glu Gly 
            100                 105                 110         


Pro Asn Ser Phe Gln Pro Ser Asp Pro Met Leu Thr Met Val Val Asp 
        115                 120                 125             


Ser Gly Leu Lys Asp Asp Leu Val Leu Gly Asp Pro Thr Ala Pro Arg 
    130                 135                 140                 


Phe Val Leu Trp Asn Gly Lys Leu Arg Pro Val Pro Ser Lys Leu Thr 
145                 150                 155                 160 


Asp Leu Pro Phe Phe Asp Leu Met Ser Ile Gly Gly Lys Ile Arg Ala 
                165                 170                 175     


Gly Phe Gly Ala Leu Gly Ile Arg Pro Ser Pro Pro Gly Arg Glu Glu 
            180                 185                 190         


Ser Val Glu Glu Phe Val Arg Arg Asn Leu Gly Asp Glu Val Phe Glu 
        195                 200                 205             


Arg Leu Ile Glu Pro Phe Cys Ser Gly Val Tyr Ala Gly Asp Pro Ser 
    210                 215                 220                 


Lys Leu Ser Met Lys Ala Ala Phe Gly Lys Val Trp Lys Leu Glu Gln 
225                 230                 235                 240 


Asn Gly Gly Ser Ile Ile Gly Gly Thr Phe Lys Ala Ile Gln Glu Arg 
                245                 250                 255     


Lys Asn Ala Pro Lys Ala Glu Arg Asp Pro Arg Leu Pro Lys Pro Gln 
            260                 265                 270         


Gly Gln Thr Val Gly Ser Phe Arg Lys Gly Leu Arg Met Leu Pro Glu 
        275                 280                 285             


Ala Ile Ser Ala Arg Leu Gly Ser Lys Val Lys Leu Ser Trp Lys Leu 
    290                 295                 300                 


Ser Gly Ile Thr Lys Leu Glu Ser Gly Gly Tyr Asn Leu Thr Tyr Glu 
305                 310                 315                 320 


Thr Pro Asp Gly Leu Val Ser Val Gln Ser Lys Ser Val Val Met Thr 
                325                 330                 335     


Val Pro Ser His Val Ala Ser Gly Leu Leu Arg Pro Leu Ser Glu Ser 
            340                 345                 350         


Ala Ala Asn Ala Leu Ser Lys Leu Tyr Tyr Pro Pro Val Ala Ala Val 
        355                 360                 365             


Ser Ile Ser Tyr Pro Lys Glu Ala Ile Arg Thr Glu Cys Leu Ile Asp 
    370                 375                 380                 


Gly Glu Leu Lys Gly Phe Gly Gln Leu His Pro Arg Thr Gln Gly Val 
385                 390                 395                 400 


Glu Thr Leu Gly Thr Ile Tyr Ser Ser Ser Leu Phe Pro Asn Arg Ala 
                405                 410                 415     


Pro Pro Gly Arg Ile Leu Leu Leu Asn Tyr Ile Gly Gly Ser Thr Asn 
            420                 425                 430         


Thr Gly Ile Leu Ser Lys Ser Glu Gly Glu Leu Val Glu Ala Val Asp 
        435                 440                 445             


Arg Asp Leu Arg Lys Met Leu Ile Lys Pro Asn Ser Thr Asp Pro Leu 
    450                 455                 460                 


Lys Leu Gly Val Arg Val Trp Pro Gln Ala Ile Pro Gln Phe Leu Val 
465                 470                 475                 480 


Gly His Phe Asp Ile Leu Asp Thr Ala Lys Ser Ser Leu Thr Ser Ser 
                485                 490                 495     


Gly Tyr Glu Gly Leu Phe Leu Gly Gly Asn Tyr Val Ala Gly Val Ala 
            500                 505                 510         


Leu Gly Arg Cys Val Glu Gly Ala Tyr Glu Thr Ala Ile Glu Val Asn 
        515                 520                 525             


Asn Phe Met Ser Arg Tyr Ala Tyr Lys 
    530                 535         


<210>  27
<211>  444
<212>  PRT
<213>  Arabidopsis thaliana

<400>  27

Lys Ala Ser Glu Ile Val Leu Gln Pro Ile Arg Glu Ile Ser Gly Leu 
1               5                   10                  15      


Ile Lys Leu Pro Gly Ser Lys Ser Leu Ser Asn Arg Ile Leu Leu Leu 
            20                  25                  30          


Ala Ala Leu Ser Glu Gly Thr Thr Val Val Asp Asn Leu Leu Asn Ser 
        35                  40                  45              


Asp Asp Ile Asn Tyr Met Leu Asp Ala Leu Lys Arg Leu Gly Leu Asn 
    50                  55                  60                  


Val Glu Thr Asp Ser Glu Asn Asn Arg Ala Val Val Glu Gly Cys Gly 
65                  70                  75                  80  


Gly Ile Phe Pro Ala Ser Ile Asp Ser Lys Ser Asp Ile Glu Leu Tyr 
                85                  90                  95      


Leu Gly Asn Ala Gly Thr Ala Met Arg Pro Leu Thr Ala Ala Val Thr 
            100                 105                 110         


Ala Ala Gly Gly Asn Ala Ser Tyr Val Leu Asp Gly Val Pro Arg Met 
        115                 120                 125             


Arg Glu Arg Pro Ile Gly Asp Leu Val Val Gly Leu Lys Gln Leu Gly 
    130                 135                 140                 


Ala Asp Val Glu Cys Thr Leu Gly Thr Asn Cys Pro Pro Val Arg Val 
145                 150                 155                 160 


Asn Ala Asn Gly Gly Leu Pro Gly Gly Lys Val Lys Leu Ser Gly Ser 
                165                 170                 175     


Ile Ser Ser Gln Tyr Leu Thr Ala Leu Leu Met Ser Ala Pro Leu Ala 
            180                 185                 190         


Leu Gly Asp Val Glu Ile Glu Ile Val Asp Lys Leu Ile Ser Val Pro 
        195                 200                 205             


Tyr Val Glu Met Thr Leu Lys Leu Met Glu Arg Phe Gly Val Ser Val 
    210                 215                 220                 


Glu His Ser Asp Ser Trp Asp Arg Phe Phe Val Lys Gly Gly Gln Lys 
225                 230                 235                 240 


Tyr Lys Ser Pro Gly Asn Ala Tyr Val Glu Gly Asp Ala Ser Ser Ala 
                245                 250                 255     


Ser Tyr Phe Leu Ala Gly Ala Ala Ile Thr Gly Glu Thr Val Thr Val 
            260                 265                 270         


Glu Gly Cys Gly Thr Thr Ser Leu Gln Gly Asp Val Lys Phe Ala Glu 
        275                 280                 285             


Val Leu Glu Lys Met Gly Cys Lys Val Ser Trp Thr Glu Asn Ser Val 
    290                 295                 300                 


Thr Val Thr Gly Pro Pro Arg Asp Ala Phe Gly Met Arg His Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Val Asn Met Asn Lys Met Pro Asp Val Ala Met Thr Leu 
                325                 330                 335     


Ala Val Val Ala Leu Phe Ala Asp Gly Pro Thr Thr Ile Arg Asp Val 
            340                 345                 350         


Ala Ser Trp Arg Val Lys Glu Thr Glu Arg Met Ile Ala Ile Cys Thr 
        355                 360                 365             


Glu Leu Arg Lys Leu Gly Ala Thr Val Glu Glu Gly Ser Asp Tyr Cys 
    370                 375                 380                 


Val Ile Thr Pro Pro Lys Lys Val Lys Thr Ala Glu Ile Asp Thr Tyr 
385                 390                 395                 400 


Asp Asp His Arg Met Ala Met Ala Phe Ser Leu Ala Ala Cys Ala Asp 
                405                 410                 415     


Val Pro Ile Thr Ile Asn Asp Pro Gly Cys Thr Arg Lys Thr Phe Pro 
            420                 425                 430         


Asp Tyr Phe Gln Val Leu Glu Arg Ile Thr Lys His 
        435                 440                 


<210>  28
<211>  534
<212>  PRT
<213>  Amaranthus tuberculatus

<400>  28

Met Val Ile Gln Ser Ile Thr His Leu Ser Pro Asn Leu Ala Leu Pro 
1               5                   10                  15      


Ser Pro Leu Ser Val Ser Thr Lys Asn Tyr Pro Val Ala Val Met Gly 
            20                  25                  30          


Asn Ile Ser Glu Arg Glu Glu Pro Thr Ser Ala Lys Arg Val Ala Val 
        35                  40                  45              


Val Gly Ala Gly Val Ser Gly Leu Ala Ala Ala Tyr Lys Leu Lys Ser 
    50                  55                  60                  


His Gly Leu Ser Val Thr Leu Phe Glu Ala Asp Ser Arg Ala Gly Gly 
65                  70                  75                  80  


Lys Leu Lys Thr Val Lys Lys Asp Gly Phe Ile Trp Asp Glu Gly Ala 
                85                  90                  95      


Asn Thr Met Thr Glu Ser Glu Ala Glu Val Ser Ser Leu Ile Asp Asp 
            100                 105                 110         


Leu Gly Leu Arg Glu Lys Gln Gln Leu Pro Ile Ser Gln Asn Lys Arg 
        115                 120                 125             


Tyr Ile Ala Arg Asp Gly Leu Pro Val Leu Leu Pro Ser Asn Pro Ala 
    130                 135                 140                 


Ala Leu Leu Thr Ser Asn Ile Leu Ser Ala Lys Ser Lys Leu Gln Ile 
145                 150                 155                 160 


Met Leu Glu Pro Phe Leu Trp Arg Lys His Asn Ala Thr Glu Leu Ser 
                165                 170                 175     


Asp Glu His Val Gln Glu Ser Val Gly Glu Phe Phe Glu Arg His Phe 
            180                 185                 190         


Gly Lys Glu Phe Val Asp Tyr Val Ile Asp Pro Phe Val Ala Gly Thr 
        195                 200                 205             


Cys Gly Gly Asp Pro Gln Ser Leu Ser Met His His Thr Phe Pro Glu 
    210                 215                 220                 


Val Trp Asn Ile Glu Lys Arg Phe Gly Ser Val Phe Ala Gly Leu Ile 
225                 230                 235                 240 


Gln Ser Thr Leu Leu Ser Lys Lys Glu Lys Gly Gly Glu Asn Ala Ser 
                245                 250                 255     


Ile Lys Lys Pro Arg Val Arg Gly Ser Phe Ser Phe Gln Gly Gly Met 
            260                 265                 270         


Gln Thr Leu Val Asp Thr Met Cys Lys Gln Leu Gly Glu Asp Glu Leu 
        275                 280                 285             


Lys Leu Gln Cys Glu Val Leu Ser Leu Ser Tyr Asn Gln Lys Gly Ile 
    290                 295                 300                 


Pro Ser Leu Gly Asn Trp Ser Val Ser Ser Met Ser Asn Asn Thr Ser 
305                 310                 315                 320 


Glu Asp Gln Ser Tyr Asp Ala Val Val Val Thr Ala Pro Ile Arg Asn 
                325                 330                 335     


Val Lys Glu Met Lys Ile Met Lys Phe Gly Asn Pro Phe Ser Leu Asp 
            340                 345                 350         


Phe Ile Pro Glu Val Thr Tyr Val Pro Leu Ser Val Met Ile Thr Ala 
        355                 360                 365             


Phe Lys Lys Asp Lys Val Lys Arg Pro Leu Glu Gly Phe Gly Val Leu 
    370                 375                 380                 


Ile Pro Ser Lys Glu Gln His Asn Gly Leu Lys Thr Leu Gly Thr Leu 
385                 390                 395                 400 


Phe Ser Ser Met Met Phe Pro Asp Arg Ala Pro Ser Asp Met Cys Leu 
                405                 410                 415     


Phe Thr Thr Phe Val Gly Gly Ser Arg Asn Arg Lys Leu Ala Asn Ala 
            420                 425                 430         


Ser Thr Asp Glu Leu Lys Gln Ile Val Ser Ser Asp Leu Gln Gln Leu 
        435                 440                 445             


Leu Gly Thr Glu Asp Glu Pro Ser Phe Val Asn His Leu Phe Trp Ser 
    450                 455                 460                 


Asn Ala Phe Pro Leu Tyr Gly His Asn Tyr Asp Ser Val Leu Arg Ala 
465                 470                 475                 480 


Ile Asp Lys Met Glu Lys Asp Leu Pro Gly Phe Phe Tyr Ala Gly Asn 
                485                 490                 495     


His Lys Gly Gly Leu Ser Val Gly Lys Ala Met Ala Ser Gly Cys Lys 
            500                 505                 510         


Ala Ala Glu Leu Val Ile Ser Tyr Leu Asp Ser His Ile Tyr Val Lys 
        515                 520                 525             


Met Asp Glu Lys Thr Ala 
    530                 


