﻿<110> 重庆精准生物技术有限公司
<120> 抗人CD19抗原的嵌合抗原受体及其应用
<160> 59

<170> PatentIn version 3.3

<210> 1
<211> 245
<212> PRT
<213> Artificial 
<220> 
<223> ScFv-humanized4
<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210> 2
<211> 245
<212> PRT
<213> Artificial
<220> 
<223> ScFv-humanized5
<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210> 3
<211>245
<212> PRT
<213> Artificial
<220> 
<223> ScFv-humanized9
<400> 3
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Ser Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210>4
<211> 245
<212> PRT
<213> Artificial
<220> 
<223> humanized11
<400>4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Val Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Leu
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210>5
<211>47 
<212> PRT
<213> 
<220> 
<223> CD8铰链
<400> 5
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
				5					10					15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg
				20					25					30
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
				35					40					45
Cys Asp

<210> 6
<211> 24
<212> PRT
<213> 
<220> 
<223> CD8跨膜区
<400>6
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
				5					10					15
Leu Ser Leu Val Ile Thr Leu Tyr Cys
				20

<211> 7
<212> PRT
<213> 27
<220> 
<223> CD28跨膜区
<400> 7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
				5					10					15
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
				20					25

<210>8
<211> 68
<212> PRT
<213> 
<220> 
<223> CD28共刺激信号
<400> 8
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
				5					10					15
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
				20					25					30
Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
				35					40					45
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
				50					55					60
Arg Asp Phe Ala Ala Tyr Arg Ser
				65

<210> 9
<211> 44
<212> PRT
<213> 
<220> 
<223> CD137共刺激信号
<400> 9
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro
				5					10					15
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser
				20					25					30
Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
				35					40

<210>10
<211> 111
<212> PRT
<213> 
<220> 
<223> CD3共刺激信号
<400> 10
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				5					10					15
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				20					25					30
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				35					40					45
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				50					55					60
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				65					70					75
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				80					85					90
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				95					100					105
Gln Ala Leu Pro Pro Arg
				110

<210> 11
<211>471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 019
<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly
				290					295					300
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
				305					310					315
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
				320					325					330
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
				335					340					345
Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

< 210 >12
<211>471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 020
<400>12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly
				290					295					300
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
				305					310					315
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
				320					325					330
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
				335					340					345
Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210> 13
<211>471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 021
<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Ser Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly
				290					295					300
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
				305					310					315
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
				320					325					330
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
				335					340					345
Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210> 14
<211> 471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 022
<400>14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Val Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Leu
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly
				290					295					300
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
				305					310					315
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
				320					325					330
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
				335					340					345
Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210>15
<211> 471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 023
<400> 15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
				290					295					300
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
				305					310					315
Cys Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
				320					325					330
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
				335					340					345
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210>16
<211>471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 024
<400>16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
				290					295					300
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
				305					310					315
Cys Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
				320					325					330
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
				335					340					345
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210>17
<211>471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 025
<400>17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Ser Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
				290					295					300
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
				305					310					315
Cys Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
				320					325					330
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
				335					340					345
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210>18
<211> 471
<212> PRT
<213> Artificial
<220> 
<223> PCAR 026
<400>18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Val Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Leu
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
				245					250					255
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
				260					265					270
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
				275					280					285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
				290					295					300
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
				305					310					315
Cys Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
				320					325					330
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
				335					340					345
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
				350					355					360
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
				365					370					375
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
				380					385					390
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
				395					400					405
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
				410					415					420
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
				425					430					435
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
				440					445					450
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
				455					460					465
Gln Ala Leu Pro Pro Arg
				470

<210> 19
<211> 735
<212>DNA
<213> Artificial
<220> 
<223> ScFv-humanized4
<400> 19
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacagcgc gctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagc                                                      735


<210>20
<211> 735
<212> DNA
<213> Artificial
<220> 
<223> ScFv-humanized5
<400> 20
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacaccag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagc                                                      735


<210> 21
<211> 735
<212> DNA
<213> Artificial
<220> 
<223> ScFv-humanized9
<400> 21
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt atagcaccag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagc                                                      735


<210> 22
<211> 735
<212> DNA
<213> Artificial
<220> 
<223> ScFv-humanized11
<400> 22
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctattt ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcgtgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacagcag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacctg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagc                                                      735


<210> 23
<211>1413
<212> DNA
<213> Artificial
<220> 
<223> PCAR 019
<400> 23
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacagcgc gctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgattttt gggtgctggt ggtggtgggc     900
ggcgtgctgg cgtgctatag cctgctggtg accgtggcgt ttattatttt ttgggtgcgc     960
agcaaacgca gccgcctgct gcatagcgat tatatgaaca tgaccccgcg ccgcccgggc    1020
ccgacccgca aacattatca gccgtatgcg ccgccgcgcg attttgcggc gtatcgcagc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413


<210> 24
<211>1413
<212> DNA
<213> Artificial
<220> 
<223>PCAR 020
<400> 24
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacaccag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgattttt gggtgctggt ggtggtgggc     900
ggcgtgctgg cgtgctatag cctgctggtg accgtggcgt ttattatttt ttgggtgcgc     960
agcaaacgca gccgcctgct gcatagcgat tatatgaaca tgaccccgcg ccgcccgggc    1020
ccgacccgca aacattatca gccgtatgcg ccgccgcgcg attttgcggc gtatcgcagc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413

<210> 25
<211>1413
<212> DNA
<213> Artificial
<220> 
<223> PCAR 021
<400>25
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt atagcaccag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgattttt gggtgctggt ggtggtgggc     900
ggcgtgctgg cgtgctatag cctgctggtg accgtggcgt ttattatttt ttgggtgcgc     960
agcaaacgca gccgcctgct gcatagcgat tatatgaaca tgaccccgcg ccgcccgggc    1020
ccgacccgca aacattatca gccgtatgcg ccgccgcgcg attttgcggc gtatcgcagc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413


<210> 26
<211>1413
<212>DNA
<213> Artificial 
<220> 
<223> PCAR 022
<400>26
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctattt ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcgtgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacagcag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacctg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgattttt gggtgctggt ggtggtgggc     900
ggcgtgctgg cgtgctatag cctgctggtg accgtggcgt ttattatttt ttgggtgcgc     960
agcaaacgca gccgcctgct gcatagcgat tatatgaaca tgaccccgcg ccgcccgggc    1020
ccgacccgca aacattatca gccgtatgcg ccgccgcgcg attttgcggc gtatcgcagc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413


<210> 27
<211>1413
<212> DNA
<213> Artificial
<220> 
<223> PCAR 023
<400>27
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacagcgc gctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgatattt atatttgggc gccgctggcg     900
ggcacctgcg gcgtgctgct gctgagcctg gtgattaccc tgtattgcgt gaaacgcggc     960
cgcaaaaaac tgctgtatat ttttaaacag ccgtttatgc gcccggtgca gaccacccag    1020
gaagaagatg gctgcagctg ccgctttccg gaagaagaag aaggcggctg cgaactgcgc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413


<210>28
<211> 1413
<212> DNA
<213> Artificial
<220> 
<223> PCAR 024
<400> 28
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacaccag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgatattt atatttgggc gccgctggcg     900
ggcacctgcg gcgtgctgct gctgagcctg gtgattaccc tgtattgcgt gaaacgcggc     960
cgcaaaaaac tgctgtatat ttttaaacag ccgtttatgc gcccggtgca gaccacccag    1020
gaagaagatg gctgcagctg ccgctttccg gaagaagaag aaggcggctg cgaactgcgc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413


<210>29
<211>1413
<212> DNA
<213> Artificial
<220> 
<223> PCAR 025
<400>29
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcctgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt atagcaccag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacatg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgatattt atatttgggc gccgctggcg     900
ggcacctgcg gcgtgctgct gctgagcctg gtgattaccc tgtattgcgt gaaacgcggc     960
cgcaaaaaac tgctgtatat ttttaaacag ccgtttatgc gcccggtgca gaccacccag    1020
gaagaagatg gctgcagctg ccgctttccg gaagaagaag aaggcggctg cgaactgcgc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413


<210> 30
<211> 1413
<212>DNA
<213> Artificial
<220> 
<223> PCAR 026
<400> 30
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgcc gcgcgagcca ggatattagc aaatatctga actggtatca gcagaaaccg     120
ggcaaagcgc cgcgcctgct gatttatcat accagccgcc tgcatagcgg cgtgccgagc     180
cgctttagcg gcagcggcag cggcaccgat tataccctga ccattagcag cctgcagccg     240
gaagattttg cgacctattt ttgccagcag ggcaacaccc tgccgtatac ctttggcggc     300
ggcacccgcc tggaaattaa aggcagcacc agcggcagcg gcaaaccggg cagcggcgaa     360
ggcagcacca aaggccaggt gcagctgcag gaaagcggcc cgggcctggt gaaaccgagc     420
cagaccctga gcgtgacctg caccgtgagc ggcgtgagcc tgccggatta tggcgtgagc     480
tggattcgcc agccgccggg caaagcgctg gaatggctgg gcgtgatttg gggcagcgaa     540
accacctatt ataacagcag cctgaaaacc cgcctgacca ttagcaaaga taacagcaaa     600
aaccaggtgg tgctgaccat gaccaacctg gatccggtgg ataccgcgac ctattattgc     660
gcgaaacatt attattatgg cggcagctat gcgatggatt attggggcca gggcagcagc     720
gtgaccgtga gcagcaaacc gaccaccacc ccggcgccgc gcccgccgac cccggcgccg     780
accattgcga gccagccgct gagcctgcgc ccggaagcgt gccgcccggc ggcgggcggc     840
gcggtgcata cccgcggcct ggattttgcg tgcgatattt atatttgggc gccgctggcg     900
ggcacctgcg gcgtgctgct gctgagcctg gtgattaccc tgtattgcgt gaaacgcggc     960
cgcaaaaaac tgctgtatat ttttaaacag ccgtttatgc gcccggtgca gaccacccag    1020
gaagaagatg gctgcagctg ccgctttccg gaagaagaag aaggcggctg cgaactgcgc    1080
gtgaaattta gccgcagcgc ggatgcgccg gcgtatcagc agggccagaa ccagctgtat    1140
aacgaactga acctgggccg ccgcgaagaa tatgatgtgc tggataaacg ccgcggccgc    1200
gatccggaaa tgggcggcaa accgcgccgc aaaaacccgc aggaaggcct gtataacgaa    1260
ctgcagaaag ataaaatggc ggaagcgtat agcgaaattg gcatgaaagg cgaacgccgc    1320
cgcggcaaag gccatgatgg cctgtatcag ggcctgagca ccgcgaccaa agatacctat    1380
gatgcgctgc atatgcaggc gctgccgccg cgc                                 1413

<210> 31
<211> 57
<212>DNA
<213> Artificial
<220> 
<223> 前导肽
<400> 31
atgggatgga gctgtatcat cctcttcctg gtagcaacag ctacaggcgt gcacagt         57


<210> 32
<211>492
<212>PRT
<213> Artificial
<220> 
<223> PCAR 003
<400> 32
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu
				5					10					15
Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser
				20					25					30
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
				35					40					45
Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys
				50					55					60
Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu
				65					70					75
His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
				80					85					90
Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
				95					100					105
Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly
				110					115					120
Gly Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly
				125					130					135
Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu
				140					145					150
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser
				155					160					165
Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val
				170					175					180
Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly
				185					190					195
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys
				200					205					210
Thr Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Val
				215					220					225
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
				230					235					240
Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
				245					250					255
Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser Lys Pro Thr Thr
				260					265					270
Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
				275					280					285
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
				290					295					300
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
				305					310					315
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
				320					325					330
Leu Val Ile Thr Leu Tyr Cys Val Lys Arg Gly Arg Lys Lys Leu
				335					340					345
Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr
				350					355					360
Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
				365					370					375
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
				380					385					390
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
				395					400					405
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
				410					415					420
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln
				425					430					435
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala
				440					445					450
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly
				455					460					465
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr
				470					475					480
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
				485					490

<210> 33
<211> 28
<212>DNA
<213> Artificial
<220> 
<223> 正向引物
<400> 33
aggctagcat gggatggagc tgtatcat                                         28

<210> 34
<211> 38
<212> DNA
<213> Artificial 
<220> 
<223> 反向引物
<400> 34
gattgtcgac ttagcgaggg ggcagggcct gcatgtga                              38



<210> 35
<211> 245
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 35
Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Pro Lys
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Glu Gln Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Ala Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Arg Lys Ala Leu Glu Trp Leu Ala Leu Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Thr Ser Leu Lys Ser Arg Leu Thr Ile Ile
				185					190					195
Lys Asp Thr Ser Lys Asn Gln Val Val Leu Lys Met Thr Asn Met
				200					205					210
Gln Thr Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210> 36
<211> 245
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Asn Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210> 37
<211> 245
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
				35					40					45
Leu Leu Ile Tyr His Thr Ser Ser Leu Gln Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
				110					115					120
Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly
				125					130					135
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
				140					145					150
Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro
				155					160					165
Pro Gly Lys Ala Leu Glu Trp Leu Ala Leu Ile Trp Gly Ser Glu
				170					175					180
Thr Thr Tyr Tyr Ser Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser
				185					190					195
Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met
				200					205					210
Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr
				215					220					225
Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser
				230					235					240
Val Thr Val Ser Ser
				245

<210> 38
<211> 120
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 38
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser
				5					10					15
Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro
				20					25					30
Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Ala Leu
				35					40					45
Glu Trp Leu Ala Leu Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn
				50					55					60
Thr Ser Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Thr Ser Lys
				65					70					75
Asn Gln Val Val Leu Lys Met Thr Asn Met Gln Thr Asp Asp Thr
				80					85					90
Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr
				95					100					105
Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser
				110					115					120

<210> 39
<211> 120
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 39
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
				5					10					15
Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro
				20					25					30
Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu
				35					40					45
Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn
				50					55					60
Ser Ser Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys
				65					70					75
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr
				80					85					90
Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr
				95					100					105
Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser
				110					115					120

<210> 40
<211> 120
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 40
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
				5					10					15
Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro
				20					25					30
Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu
				35					40					45
Glu Trp Leu Ala Leu Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser
				50					55					60
Thr Ser Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys
				65					70					75
Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr
				80					85					90
Ala Thr Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr
				95					100					105
Ala Met Asp Tyr Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser
				110					115					120

<210> 41
<211> 107 
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 41
Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Pro Lys
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Glu Gln Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys


<210> 42
<211> 107
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg
				35					40					45
Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys


<210> 43
<211> 107
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 43
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
				5					10					15
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
				20					25					30
Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
				35					40					45
Leu Leu Ile Tyr His Thr Ser Ser Leu Gln Ser Gly Val Pro Ser
				50					55					60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
				65					70					75
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
				80					85					90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu
				95					100					105
Ile Lys

<210> 44
<211> 234
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 44
Ala Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
				5					10					15
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
				20					25					30
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
				35					40					45
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
				50					55					60
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
				65					70					75
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
				80					85					90
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
				95					100					105
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
				110					115					120
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
				125					130					135
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
				140					145					150
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
				155					160					165
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
				170					175					180
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
				185					190					195
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
				200					205					210
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
				215					220					225
Gln Lys Ser Leu Ser Leu Ser Pro Gly
				230

<210> 45
<211> 497
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 45
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu
				5					10					15
Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Thr Ser
				20					25					30
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
				35					40					45
Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys
				50					55					60
Pro Asp Gly Thr Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu
				65					70					75
His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
				80					85					90
Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Phe Ala
				95					100					105
Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly
				110					115					120
Gly Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly
				125					130					135
Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu
				140					145					150
Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Thr Leu Ser
				155					160					165
Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val
				170					175					180
Ser Trp Ile Arg Gln Pro Pro Arg Lys Ala Leu Glu Trp Leu Ala
				185					190					195
Leu Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Thr Ser Leu Lys
				200					205					210
Ser Arg Leu Thr Ile Ile Lys Asp Thr Ser Lys Asn Gln Val Val
				215					220					225
Leu Lys Met Thr Asn Met Gln Thr Asp Asp Thr Ala Val Tyr Tyr
				230					235					240
Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
				245					250					255
Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser Leu Glu Lys Pro
				260					265					270
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
				275					280					285
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
				290					295					300
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
				305					310					315
Glu Phe Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
				320					325					330
Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
				335					340					345
Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
				350					355					360
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
				365					370					375
Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser
				380					385					390
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu
				395					400					405
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
				410					415					420
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
				425					430					435
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
				440					445					450
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
				455					460					465
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
				470					475					480
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
				485					490					495
Pro Arg

<210> 46
<211> 497
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu
				5					10					15
Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser
				20					25					30
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
				35					40					45
Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys
				50					55					60
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr His Thr Ser Ser Leu
				65					70					75
Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
				80					85					90
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
				95					100					105
Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly
				110					115					120
Gly Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly
				125					130					135
Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu
				140					145					150
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser
				155					160					165
Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val
				170					175					180
Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala
				185					190					195
Leu Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Thr Ser Leu Lys
				200					205					210
Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val
				215					220					225
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
				230					235					240
Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
				245					250					255
Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser Leu Glu Lys Pro
				260					265					270
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
				275					280					285
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
				290					295					300
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
				305					310					315
Glu Phe Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
				320					325					330
Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
				335					340					345
Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
				350					355					360
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
				365					370					375
Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser
				380					385					390
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu
				395					400					405
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
				410					415					420
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
				425					430					435
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
				440					445					450
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
				455					460					465
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
				470					475					480
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
				485					490					495
Pro Arg

<210> 47
<211> 497
<212> PRT
<213> Artificial 
<220> 
<223>
<400> 47
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu
				5					10					15
Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser
				20					25					30
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
				35					40					45
Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys
				50					55					60
Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu
				65					70					75
His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
				80					85					90
Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
				95					100					105
Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly
				110					115					120
Gly Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly
				125					130					135
Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu
				140					145					150
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser
				155					160					165
Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val
				170					175					180
Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly
				185					190					195
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys
				200					205					210
Thr Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Val
				215					220					225
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
				230					235					240
Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
				245					250					255
Trp Gly Gln Gly Ser Ser Val Thr Val Ser Ser Leu Glu Lys Pro
				260					265					270
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
				275					280					285
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
				290					295					300
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
				305					310					315
Glu Phe Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
				320					325					330
Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
				335					340					345
Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
				350					355					360
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
				365					370					375
Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser
				380					385					390
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu
				395					400					405
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
				410					415					420
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
				425					430					435
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
				440					445					450
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
				455					460					465
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
				470					475					480
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
				485					490					495
Pro Arg

<210> 48
<211> 1494
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 48
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctaga      60
cccgacatcc agatgaccca gagcacaagc tctctgagcg ccagcgtggg agacagagtg     120
accatcactt gcagggccag ccaggacatc agcaagtacc tgaattggta ccagcagaag     180
cccgacggca cacctaagct gctgatctac cacacaagca gactgcacag cggagtgcct     240
agcagattca gcggcagcgg aagcggaacc gactacaccc tgaccatcag cagcctggag     300
caggaggact tcgccaccta ctactgccag cagggcaaca cactgcctta caccttcggc     360
ggaggcacaa gactggagat caagggcagc acaagcggaa gcggcaaacc aggaagcgga     420
gaaggaagca ccaagggaca ggtgcagctg caggaatcag gaccaggact ggtggctcct     480
tctcagaccc tgagcctgac ttgcaccgtg tcaggagtgt ccctgccaga ttacggcgtg     540
tcttggatca gacagccccc cagaaaggcc ctggagtggc tggctctgat ttggggaagc     600
gagaccacct actacaacac cagcctgaag agccggctga ccatcatcaa ggacaccagc     660
aagaaccagg tggtgctgaa gatgaccaac atgcagaccg acgacaccgc cgtgtactat     720
tgcgccaagc actactacta cggcggaagc tacgccatgg actattgggg ccagggaagc     780
agcgtgaccg tgtctagcct cgagaagccc accacgacgc cagcgccgcg accaccaaca     840
ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     900
gcggggggcg cagtgcacac gagggggctg gacttcgcct gcgacgaatt cttctgggtg     960
ctggtcgtgg tgggtggcgt gctggcctgc tacagcctgc tggtgacagt ggccttcatc    1020
atcttttggg tgaggagcaa gcggagcaga ggcggccaca gcgactacat gaacatgact    1080
ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc    1140
gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag    1200
ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg    1260
gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag    1320
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg    1380
atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca    1440
gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa          1494

<210> 49
<211> 1494
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 49
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctaga      60
cccgacatcc agatgaccca gagcccttct tctctgagcg ccagcgtggg agacagagtg     120
accatcactt gcagggccag ccaggacatc agcaagtacc tgaattggta ccagcagaag     180
ccaggcaagg cccctaagct gctgatctac cacacatcta gcctgcagag cggagtgcct     240
agcagattca gcggcagcgg aagcggaacc gacttcaccc tgaccatcag cagcctgcag     300
ccagaggact tcgccaccta ctactgccag cagggcaaca cactgcctta caccttcggc     360
ggaggcacaa gactggagat caagggcagc acaagcggaa gcggcaaacc aggaagcgga     420
gaaggaagca ccaagggaca ggtgcagctg caggaaagcg gaccaggact ggtgaagcct     480
tctcagaccc tgagcctgac ttgcaccgtg tcaggagtgt ccctgccaga ttacggcgtg     540
tcttggatca gacagccccc aggaaaggcc ctggagtggc tggctctgat ttggggaagc     600
gagaccacct actacagcac cagcctgaag acccggctga caatcagcaa ggacaccagc     660
aagaaccagg tggtgctgac catgaccaac atggaccccg tggacaccgc cacctactat     720
tgcgccaagc actactacta cggcggaagc tacgccatgg actattgggg ccagggaagc     780
agcgtgaccg tgtctagcct cgagaagccc accacgacgc cagcgccgcg accaccaaca     840
ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     900
gcggggggcg cagtgcacac gagggggctg gacttcgcct gcgacgaatt cttctgggtg     960
ctggtcgtgg tgggtggcgt gctggcctgc tacagcctgc tggtgacagt ggccttcatc    1020
atcttttggg tgaggagcaa gcggagcaga ggcggccaca gcgactacat gaacatgact    1080
ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc    1140
gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag    1200
ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg    1260
gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag    1320
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg    1380
atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca    1440
gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa          1494

<210> 50
<211> 1494
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 50
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctaga      60
cccgacatcc agatgaccca gagcccttct tctctgagcg ccagcgtggg agacagagtg     120
accatcactt gcagggccag ccaggacatc agcaagtacc tgaattggta ccagcagaag     180
ccaggcaagg cccctagact gctgatctac cacacaagca gactgcacag cggagtgcct     240
agcagattca gcggcagcgg aagcggaacc gactacaccc tgaccatcag cagcctgcag     300
ccagaggact tcgccaccta ctactgccag cagggcaaca cactgcctta caccttcggc     360
ggaggcacaa gactggagat caagggcagc acaagcggaa gcggcaaacc aggaagcgga     420
gaaggaagca ccaagggaca ggtgcagctg caggaaagcg gaccaggact ggtgaagcct     480
tctcagaccc tgagcctgac ttgcaccgtg tcaggagtgt ccctgccaga ttacggcgtg     540
tcttggatca gacagccccc aggaaaggcc ctggagtggc tgggagtgat ttggggaagc     600
gagaccacct actacaacag cagcctgaag acccggctga ccatcagcaa ggacaacagc     660
aagaaccagg tggtgctgac catgaccaac atggaccccg tggacaccgc cacctactat     720
tgcgccaagc actactacta cggcggaagc tacgccatgg actattgggg ccagggaagc     780
agcgtgaccg tgtctagcct cgagaagccc accacgacgc cagcgccgcg accaccaaca     840
ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     900
gcggggggcg cagtgcacac gagggggctg gacttcgcct gcgacgaatt cttctgggtg     960
ctggtcgtgg tgggtggcgt gctggcctgc tacagcctgc tggtgacagt ggccttcatc    1020
atcttttggg tgaggagcaa gcggagcaga ggcggccaca gcgactacat gaacatgact    1080
ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc    1140
gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag    1200
ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg    1260
gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag    1320
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg    1380
atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca    1440
gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa          1494

<210> 51
<211> 735
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 51
gacatccaga tgacccagag cacaagctct ctgagcgcca gcgtgggaga cagagtgacc      60
atcacttgca gggccagcca ggacatcagc aagtacctga attggtacca gcagaagccc     120
gacggcacac ctaagctgct gatctaccac acaagcagac tgcacagcgg agtgcctagc     180
agattcagcg gcagcggaag cggaaccgac tacaccctga ccatcagcag cctggagcag     240
gaggacttcg ccacctacta ctgccagcag ggcaacacac tgccttacac cttcggcgga     300
ggcacaagac tggagatcaa gggcagcaca agcggaagcg gcaaaccagg aagcggagaa     360
ggaagcacca agggacaggt gcagctgcag gaatcaggac caggactggt ggctccttct     420
cagaccctga gcctgacttg caccgtgtca ggagtgtccc tgccagatta cggcgtgtct     480
tggatcagac agccccccag aaaggccctg gagtggctgg ctctgatttg gggaagcgag     540
accacctact acaacaccag cctgaagagc cggctgacca tcatcaagga caccagcaag     600
aaccaggtgg tgctgaagat gaccaacatg cagaccgacg acaccgccgt gtactattgc     660
gccaagcact actactacgg cggaagctac gccatggact attggggcca gggaagcagc     720
gtgaccgtgt ctagc                                                      735

<210> 52
<211> 735
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 52
gacatccaga tgacccagag cccttcttct ctgagcgcca gcgtgggaga cagagtgacc      60
atcacttgca gggccagcca ggacatcagc aagtacctga attggtacca gcagaagcca     120
ggcaaggccc ctaagctgct gatctaccac acatctagcc tgcagagcgg agtgcctagc     180
agattcagcg gcagcggaag cggaaccgac ttcaccctga ccatcagcag cctgcagcca     240
gaggacttcg ccacctacta ctgccagcag ggcaacacac tgccttacac cttcggcgga     300
ggcacaagac tggagatcaa gggcagcaca agcggaagcg gcaaaccagg aagcggagaa     360
ggaagcacca agggacaggt gcagctgcag gaaagcggac caggactggt gaagccttct     420
cagaccctga gcctgacttg caccgtgtca ggagtgtccc tgccagatta cggcgtgtct     480
tggatcagac agcccccagg aaaggccctg gagtggctgg ctctgatttg gggaagcgag     540
accacctact acagcaccag cctgaagacc cggctgacaa tcagcaagga caccagcaag     600
aaccaggtgg tgctgaccat gaccaacatg gaccccgtgg acaccgccac ctactattgc     660
gccaagcact actactacgg cggaagctac gccatggact attggggcca gggaagcagc     720
gtgaccgtgt ctagc                                                      735

<210> 53
<211> 735
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 53
gacatccaga tgacccagag cccttcttct ctgagcgcca gcgtgggaga cagagtgacc      60
atcacttgca gggccagcca ggacatcagc aagtacctga attggtacca gcagaagcca     120
ggcaaggccc ctagactgct gatctaccac acaagcagac tgcacagcgg agtgcctagc     180
agattcagcg gcagcggaag cggaaccgac tacaccctga ccatcagcag cctgcagcca     240
gaggacttcg ccacctacta ctgccagcag ggcaacacac tgccttacac cttcggcgga     300
ggcacaagac tggagatcaa gggcagcaca agcggaagcg gcaaaccagg aagcggagaa     360
ggaagcacca agggacaggt gcagctgcag gaaagcggac caggactggt gaagccttct     420
cagaccctga gcctgacttg caccgtgtca ggagtgtccc tgccagatta cggcgtgtct     480
tggatcagac agcccccagg aaaggccctg gagtggctgg gagtgatttg gggaagcgag     540
accacctact acaacagcag cctgaagacc cggctgacca tcagcaagga caacagcaag     600
aaccaggtgg tgctgaccat gaccaacatg gaccccgtgg acaccgccac ctactattgc     660
gccaagcact actactacgg cggaagctac gccatggact attggggcca gggaagcagc     720
gtgaccgtgt ctagc                                                      735


<210> 54
<211> 704
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 54
gcggccgccg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      60
gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     120
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     180
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     240
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     300
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     360
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     420
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     480
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     540
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     600
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     660
cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaa                      704


<210> 55
<211> 72
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 55
gatcccaaac tctgctacct gctggatgga atcctcttca tctatggtgt cattctcact      60
gccttgttcc tg                                                          72


<210> 56
<211> 204
<212> DNA
<213> Artificial 
<220> 
<223> CD28
<400> 56
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg      60
gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     120
aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     180
cgcgacttcg cagcctatcg ctcc                                            204


<210> 57
<211> 129
<212> DNA
<213> Artificial 
<220> 
<223> CD137
<400> 57
gttaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta      60
caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     120
tgtgaactg                                                             129

<210> 58
<211> 1494
<212> DNA
<213> Artificial 
<220> 
<223> mCD19
<400> 58
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctaga      60
cccgacatcc agatgaccca gaccacctcc agcctgagcg ccagcctggg cgaccgggtg     120
accatcagct gccgggccag ccaggacatc agcaagtacc tgaactggta tcagcagaag     180
cccgacggca ccgtcaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc     240
agccggttta gcggcagcgg ctccggcacc gactacagcc tgaccatctc caacctggag     300
caggaggaca tcgccaccta cttttgccag cagggcaaca cactgcccta cacctttggc     360
ggcggaacaa agctggagat caccggcagc acctccggca gcggcaagcc tggcagcggc     420
gagggcagca ccaagggcga ggtgaagctg caggagagcg gccctggcct ggtggccccc     480
agccagagcc tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcccga ctacggcgtg     540
tcctggatcc ggcagccccc taggaagggc ctggagtggc tgggcgtgat ctggggcagc     600
gagaccacct actacaacag cgccctgaag agccggctga ccatcatcaa ggacaacagc     660
aagagccagg tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac     720
tgtgccaagc actactacta cggcggcagc tacgccatgg actactgggg ccagggcacc     780
agcgtgaccg tgtccagcct cgagaagccc accacgacgc cagcgccgcg accaccaaca     840
ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     900
gcggggggcg cagtgcacac gagggggctg gacttcgcct gcgacgaatt cttctgggtg     960
ctggtcgtgg tgggtggcgt gctggcctgc tacagcctgc tggtgacagt ggccttcatc    1020
atcttttggg tgaggagcaa gcggagcaga ggcggccaca gcgactacat gaacatgact    1080
ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc    1140
gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag    1200
ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg    1260
gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag    1320
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg    1380
atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca    1440
gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa          1494


<210> 59
<211> 24
<212> PRT
<213> Artificial 
<220> 
<223> 
<400> 59
Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr
				5					10					15
Gly Val Ile Leu Thr Ala Leu Phe Leu
				20