                         SEQUENCE LISTING

<110>  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120>  TARGETING GAMMA-DELTA T CELLS IN OBESITY AND CACHEXIA

<130>  29618-0163WO1

<140>  PCT/US2018/030153
<141>  2018-04-30

<150>  US 62/491,753
<151>  2017-04-28

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  3
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            260                 265                 270 


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Il10 reverse

<400>  4
cagactcaat acacactg                                                     18


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Il33 forward

<400>  5
atgggaagaa gctgatggtg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Il33 reverse

<400>  6
ccgaggactt tttgtgaagg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Ucp1 forward

<400>  7
ggcctctacg actcagtcca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Ucp1 reverse

<400>  8
taagccggct gagatcttgt                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Ppargc1a forward

<400>  9
agccgtgacc actgacaacg ag                                                22


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Ppargc1a reverse

<400>  10
gctgcatggt tctgagtgct aag                                               23


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Dio2 forward

<400>  11
tgccaccttc ttgactttgc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Dio2 reverse

<400>  12
ggttccggtg cttcttaacc                                                   20


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Cox7a1 forward

<400>  13
aaaccgtgtg gcagagaagc ag                                                22


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Cox7a1 reverse

<400>  14
cccaagcagt ataagcagta ggc                                               23


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Adrb3 forward

<400>  15
aactgaaaca gcagacaggg ac                                                22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Adrb3 reverse

<400>  16
cccccatgta caccctagtt                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Th forward

<400>  17
ccaaggttca ttggacggc                                                    19


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Th reverse

<400>  18
ctctcctcga ataccacagc                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Lipe forward

<400>  19
gctcatctcc tatgacctac gg                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Lipe reverse

<400>  20
tccgtggatg tgaacaacca gg                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Pnpla2 forward

<400>  21
ggaaccaaag gacctgatga cc                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Pnpla2 reverse

<400>  22
acatcaggca gccactccaa ca                                                22


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence 

<220>
<223>  oligonucleotide primer Tbp forward

<400>  23
ctaccgtgaa tcttggctgt aaac                                              24


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Tbp reverse

<400>  24
aatcaacgca gttgtccgtg gc                                                22


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer Il10 forward

<400>  25
aataagctcc aagaccaagg                                                   20


