                         SEQUENCE LISTING

<110>  Stowers Institute For Medical Research
 
<120>  COMPOSITIONS AND METHODS OF DUAL POISON-ANTIDOTE MEIOTIC DRIVERS

<130>  C065334/2391204

<140>  US 62/491,107
<141>  2017-04-27

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  295
<212>  PRT
<213>  Schizosaccharomyces

<400>  1

Met Leu Ser Glu Ile Trp Lys Tyr Ile Lys Thr Val Ser Glu Asp Ser 
1               5                   10                  15      


Ser Thr Gly Pro Thr Glu Thr Thr Asn Pro Asn Val Glu Arg Arg Gln 
            20                  25                  30          


Glu Phe Lys Asp Ser His Pro Asn Ile Tyr Ser Leu Leu Arg Leu Leu 
        35                  40                  45              


Ile Ser Val Leu Ala Val Ile Val Val Phe Phe Thr Ala Trp Val Cys 
    50                  55                  60                  


Val Asn Pro Leu Glu Lys Ser Ile Phe Gly Lys Val Ala Phe Phe Val 
65                  70                  75                  80  


Thr Ile Gly Ile Thr Cys Pro Ile Leu Leu Ile Thr Ile Phe Cys Phe 
                85                  90                  95      


Phe Glu Thr Trp Thr Gln Ala Val Ala Gln Cys Ile Lys Val Thr Val 
            100                 105                 110         


Ile Phe Leu Ala Gln Cys Val Lys Val Thr Ala Val Gly Leu Tyr Asn 
        115                 120                 125             


Ser Arg Glu Lys Trp Val Val Ile Ile Trp Leu Leu Trp Val Val Ile 
    130                 135                 140                 


Cys Tyr Thr Leu Phe Leu Arg Ser Lys Phe Gly Asn Leu Asn Leu Asn 
145                 150                 155                 160 


Lys Ala Leu Ile Cys Ser Thr Cys Ser Ile Ser Ala Ala Leu Leu Leu 
                165                 170                 175     


Phe Leu Leu Tyr Val Arg Leu Pro Phe Trp Thr Leu Lys His Met Phe 
            180                 185                 190         


Ser Gly Leu Phe Gln Val Leu Gly Val Gln Ser Cys Val Val Ile Val 
        195                 200                 205             


Thr Lys Gly Leu Thr Tyr Leu Phe Asp Lys His Ile Asp Ala Thr Gly 
    210                 215                 220                 


Tyr Glu Ile Glu Ala Ser Ser Leu Phe Val Ile Gly Asn Phe Leu Phe 
225                 230                 235                 240 


Phe Tyr Glu Met Glu Cys Pro Gly Ala Leu Lys Arg Met Pro Lys Phe 
                245                 250                 255     


Ile Arg Asn Gly Ile Ala Ser Phe Leu Glu Gly Ile Gly Asn Ile Gly 
            260                 265                 270         


Arg Ala Phe Arg Gly Ala Asn Asp Asn Asn Asp Ile Pro Leu Gly Glu 
        275                 280                 285             


Met Glu Val Glu Ser Glu Val 
    290                 295 


<210>  2
<211>  337
<212>  PRT
<213>  Schizosaccharomyces

<400>  2

Met Lys Asn Lys Asp Tyr Pro Leu Arg Ser Ser Met Asp Glu Leu Ser 
1               5                   10                  15      


Thr Lys Asn Asp Asn Glu Ile Asp Leu Glu Lys Gly Pro Leu Pro Glu 
            20                  25                  30          


Tyr Asn Ser Glu Asp Glu Ser Thr Leu Pro Pro Tyr Ser Glu Ile Trp 
        35                  40                  45              


Lys Tyr Ile Lys Thr Val Ser Glu Asp Ser Ser Thr Gly Pro Thr Glu 
    50                  55                  60                  


Thr Thr Asn Pro Asn Val Glu Arg Arg Gln Glu Phe Lys Asp Ser His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ser Leu Leu Arg Leu Leu Ile Ser Val Leu Ala Val 
                85                  90                  95      


Ile Val Val Phe Phe Thr Ala Trp Val Cys Val Asn Pro Leu Glu Lys 
            100                 105                 110         


Ser Ile Phe Gly Lys Val Ala Phe Phe Val Thr Ile Gly Ile Thr Cys 
        115                 120                 125             


Pro Ile Leu Leu Ile Thr Ile Phe Cys Phe Phe Glu Thr Trp Thr Gln 
    130                 135                 140                 


Ala Val Ala Gln Cys Ile Lys Val Thr Val Ile Phe Leu Ala Gln Cys 
145                 150                 155                 160 


Val Lys Val Thr Ala Val Gly Leu Tyr Asn Ser Arg Glu Lys Trp Val 
                165                 170                 175     


Val Ile Ile Trp Leu Leu Trp Val Val Ile Cys Tyr Thr Leu Phe Leu 
            180                 185                 190         


Arg Ser Lys Phe Gly Asn Leu Asn Leu Asn Lys Ala Leu Ile Cys Ser 
        195                 200                 205             


Thr Cys Ser Ile Ser Ala Ala Leu Leu Leu Phe Leu Leu Tyr Val Arg 
    210                 215                 220                 


Leu Pro Phe Trp Thr Leu Lys His Met Phe Ser Gly Leu Phe Gln Val 
225                 230                 235                 240 


Leu Gly Val Gln Ser Cys Val Val Ile Val Thr Lys Gly Leu Thr Tyr 
                245                 250                 255     


Leu Phe Asp Lys His Ile Asp Ala Thr Gly Tyr Glu Ile Glu Ala Ser 
            260                 265                 270         


Ser Leu Phe Val Ile Gly Asn Phe Leu Phe Phe Tyr Glu Met Glu Cys 
        275                 280                 285             


Pro Gly Ala Leu Lys Arg Met Pro Lys Phe Ile Arg Asn Gly Ile Ala 
    290                 295                 300                 


Ser Phe Leu Glu Gly Ile Gly Asn Ile Gly Arg Ala Phe Arg Gly Ala 
305                 310                 315                 320 


Asn Asp Asn Asn Asp Ile Pro Leu Gly Glu Met Glu Val Glu Ser Glu 
                325                 330                 335     


Val 
    


<210>  3
<211>  342
<212>  PRT
<213>  Schizosaccharomyces

<400>  3

Met Gly Gln Asn Ile Thr Lys Leu Phe Asn Trp Asn Lys Ser Thr Thr 
1               5                   10                  15      


Pro Pro Asp Tyr Asp Glu Asn Arg Leu Pro Ile Thr Asp Glu Gly Asn 
            20                  25                  30          


Asn Pro Pro Asn Thr His Arg Glu Asn His Ser Ser Gly Thr Ala Asp 
        35                  40                  45              


Asn Ser Ser Pro Phe Leu Ile Lys Leu Ile Ile Ser Phe Thr Pro Ile 
    50                  55                  60                  


Phe Val Leu Asn Val Pro Ala Val Cys Tyr Leu Thr Tyr Lys Asp Ala 
65                  70                  75                  80  


Leu Phe Lys Asp Tyr Gly Lys Asp Glu Trp Val Tyr Phe Gly Val Trp 
                85                  90                  95      


Cys Ala Ile Cys Leu Met Ser Phe Ile Ser Leu Trp Cys Phe Tyr Glu 
            100                 105                 110         


Thr Trp Thr Lys Ala Val Lys Val Thr Val Ile Phe Leu Ala Gln Cys 
        115                 120                 125             


Val Lys Val Thr Val Ile Phe Leu Ala Gln Cys Val Lys Val Thr Ala 
    130                 135                 140                 


Ile Phe Ser Ala Gln Cys Ile Lys Val Thr Val Ile Ser Leu Ala Lys 
145                 150                 155                 160 


Cys Val Lys Val Ile Ala Val Gly Leu Tyr Asn Ser Lys Lys Asp Leu 
                165                 170                 175     


Val Val Thr Ile Trp Leu Ala Trp Val Val Ile Cys Phe Ile Leu Phe 
            180                 185                 190         


Gly Cys Val Lys Asp Gly Arg Leu Asn Leu Asn Lys Ala Leu Ile Cys 
        195                 200                 205             


Ser Thr Ser Ser Ile Ser Ala Ala Leu Phe Phe Ile Leu Leu Leu Val 
    210                 215                 220                 


Cys Ile Pro Ile Trp Thr Leu Lys His Met Leu Phe Gly Leu Phe Gln 
225                 230                 235                 240 


Val Leu Gly Val Gln Ser Cys Val Val Ile Val Thr Lys Gly Leu Met 
                245                 250                 255     


Tyr Leu Phe Asp Lys His Ile Asp Ala Thr Gly Tyr Glu Ile Glu Ala 
            260                 265                 270         


Ser Ser Leu Phe Val Ile Gly Asn Phe Leu Phe Phe Tyr Glu Met Glu 
        275                 280                 285             


Arg Pro Gly Ala Leu Lys Arg Met Pro Lys Phe Ile Arg Asn Gly Ile 
    290                 295                 300                 


Ala Ser Phe Leu Gly Gly Ile Ala Asn Ala Phe Gly Gly Ile Ala Asn 
305                 310                 315                 320 


Ala Ile Arg Gly Ala Asn Asp Asn Asn Asp Ile Pro Leu Gly Glu Met 
                325                 330                 335     


Glu Val Glu Ser Glu Val 
            340         


<210>  4
<211>  397
<212>  PRT
<213>  Schizosaccharomyces

<400>  4

Met Lys Asn Lys Tyr Tyr Pro Leu Arg Ser Ser Met Asp Glu Leu Ser 
1               5                   10                  15      


Thr Lys Asn Asp Asn Glu Ile Asp Leu Glu Lys Gly Pro Leu Pro Glu 
            20                  25                  30          


Tyr Asn Ser Glu Asp Gly Asn Thr Leu Pro Pro Tyr Ser Glu Asn Ile 
        35                  40                  45              


Asn Leu Lys Asp Pro Lys Gln Met Gly Gln Asn Ile Thr Lys Leu Phe 
    50                  55                  60                  


Asn Trp Asn Lys Ser Thr Thr Pro Pro Asp Tyr Asp Glu Asn Arg Leu 
65                  70                  75                  80  


Pro Ile Thr Asp Glu Gly Asn Asn Pro Pro Asn Thr His Arg Glu Asn 
                85                  90                  95      


His Ser Ser Gly Thr Ala Asp Asn Ser Ser Pro Phe Leu Ile Lys Leu 
            100                 105                 110         


Ile Ile Ser Phe Thr Pro Ile Phe Val Leu Asn Val Pro Ala Val Cys 
        115                 120                 125             


Tyr Leu Thr Tyr Lys Asp Ala Leu Phe Lys Asp Tyr Gly Lys Asp Glu 
    130                 135                 140                 


Trp Val Tyr Phe Gly Val Trp Cys Ala Ile Cys Leu Met Ser Phe Ile 
145                 150                 155                 160 


Ser Leu Trp Cys Phe Tyr Glu Thr Trp Thr Lys Ala Val Lys Val Thr 
                165                 170                 175     


Val Ile Phe Leu Ala Gln Cys Val Lys Val Thr Val Ile Phe Leu Ala 
            180                 185                 190         


Gln Cys Val Lys Val Thr Ala Ile Phe Ser Ala Gln Cys Ile Lys Val 
        195                 200                 205             


Thr Val Ile Ser Leu Ala Lys Cys Val Lys Val Ile Ala Val Gly Leu 
    210                 215                 220                 


Tyr Asn Ser Lys Lys Asp Leu Val Val Thr Ile Trp Leu Ala Trp Val 
225                 230                 235                 240 


Val Ile Cys Phe Ile Leu Phe Gly Cys Val Lys Asp Gly Arg Leu Asn 
                245                 250                 255     


Leu Asn Lys Ala Leu Ile Cys Ser Thr Ser Ser Ile Ser Ala Ala Leu 
            260                 265                 270         


Phe Phe Ile Leu Leu Leu Val Cys Ile Pro Ile Trp Thr Leu Lys His 
        275                 280                 285             


Met Leu Phe Gly Leu Phe Gln Val Leu Gly Val Gln Ser Cys Val Val 
    290                 295                 300                 


Ile Val Thr Lys Gly Leu Met Tyr Leu Phe Asp Lys His Ile Asp Ala 
305                 310                 315                 320 


Thr Gly Tyr Glu Ile Glu Ala Ser Ser Leu Phe Val Ile Gly Asn Phe 
                325                 330                 335     


Leu Phe Phe Tyr Glu Met Glu Arg Pro Gly Ala Leu Lys Arg Met Pro 
            340                 345                 350         


Lys Phe Ile Arg Asn Gly Ile Ala Ser Phe Leu Gly Gly Ile Ala Asn 
        355                 360                 365             


Ala Phe Gly Gly Ile Ala Asn Ala Ile Arg Gly Ala Asn Asp Asn Asn 
    370                 375                 380                 


Asp Ile Pro Leu Gly Glu Met Glu Val Glu Ser Glu Val 
385                 390                 395         


<210>  5
<211>  100
<212>  DNA
<213>  oligo

<400>  5
tattacatca gtgcgctatc agtttaaaag gttgggccta ctaacttaac atatactaca       60

cctcaagaaa aagaaagaac acatacgatt taggtgacac                            100


<210>  6
<211>  100
<212>  DNA
<213>  oligo

<400>  6
tttgcacagc agaaatttga ttattgcttg gctcaagtac atggtgagta tgacattatt       60

attgagaacg acctggcata atacgactca ctatagggag                            100


<210>  7
<211>  41
<212>  DNA
<213>  oligo

<400>  7
gtcggatccc attcgttatc gttccaagtg tgctgccgtc g                           41


<210>  8
<211>  55
<212>  DNA
<213>  oligo

<400>  8
gtcagatctc tgttttggaa acttttttat cctctaacga tgacgataaa tttac            55


<210>  9
<211>  44
<212>  DNA
<213>  oligo

<400>  9
gtcgagctca atacaggtaa atggtctaaa tcagtatgta agcc                        44


<210>  10
<211>  42
<212>  DNA
<213>  oligo

<400>  10
gtcactagtg ctatgattcc gggaattgat gtttcttctg ac                          42


<210>  11
<211>  29
<212>  DNA
<213>  oligo

<400>  11
ctctgaagac gcaggtagta aaaaacccg                                         29


<210>  12
<211>  31
<212>  DNA
<213>  oligo

<400>  12
gtgagtatgt accttcaata cacccttgat g                                      31


<210>  13
<211>  29
<212>  DNA
<213>  oligo

<400>  13
ctgcgtagct gacatgttat tgcgataac                                         29


<210>  14
<211>  29
<212>  DNA
<213>  oligo

<400>  14
gcattgcttg aaagattctg cgatgttgg                                         29


<210>  15
<211>  35
<212>  DNA
<213>  oligo

<400>  15
ggttagagta aattacagga atatataacg aaccc                                  35


<210>  16
<211>  35
<212>  DNA
<213>  oligo

<400>  16
gggttcgtta tatattcctg taatttactc taacc                                  35


<210>  17
<211>  29
<212>  DNA
<213>  oligo

<400>  17
ctaccttgcc gaatatcgac ttctccaac                                         29


<210>  18
<211>  29
<212>  DNA
<213>  oligo

<400>  18
gttggagaag tcgatattcg gcaaggtag                                         29


<210>  19
<211>  26
<212>  DNA
<213>  oligo

<400>  19
ctgaacgagg cagtggattg cttctg                                            26


<210>  20
<211>  26
<212>  DNA
<213>  oligo

<400>  20
cagaagcaat ccactgcctc gttcag                                            26


<210>  21
<211>  30
<212>  DNA
<213>  oligo

<400>  21
gttatgatgg agaacccgga aattagaggc                                        30


<210>  22
<211>  51
<212>  DNA
<213>  oligo

<400>  22
gtgtcaccta aatcgtatgt ggggaacaga aataaacaag tctaaagtgc c                51


<210>  23
<211>  52
<212>  DNA
<213>  oligo

<400>  23
ctccctatag tgagtcgtat taaactgcgt agctgacatg acactgaatt tc               52


<210>  24
<211>  30
<212>  DNA
<213>  oligo

<400>  24
ccaggcaaca tccattctca tcagatgagg                                        30


<210>  25
<211>  33
<212>  DNA
<213>  oligo

<400>  25
atttctgttc cccacatacg atttaggtga cac                                    33


<210>  26
<211>  35
<212>  DNA
<213>  oligo

<400>  26
cagctacgca gtttaatacg actcactata gggag                                  35


<210>  27
<211>  22
<212>  DNA
<213>  oligo

<400>  27
cattttcaca aatggttcga gt                                                22


<210>  28
<211>  22
<212>  DNA
<213>  oligo

<400>  28
tcgaaccatt tgtgaaaatg tt                                                22


<210>  29
<211>  29
<212>  DNA
<213>  oligo

<400>  29
tggttaagca tgtgatcttc atacgacgc                                         29


<210>  30
<211>  29
<212>  DNA
<213>  oligo

<400>  30
agaaattcag tgtcatgtca gctacgcag                                         29


<210>  31
<211>  27
<212>  DNA
<213>  oligo

<400>  31
atgagcgaaa aacaggttgt agggatc                                           27


<210>  32
<211>  29
<212>  DNA
<213>  oligo

<400>  32
ggtacctgac ctgaattgtg aggccgagg                                         29


<210>  33
<211>  25
<212>  DNA
<213>  oligo

<400>  33
ccatagcagc caaaagggag ggttg                                             25


<210>  34
<211>  44
<212>  DNA
<213>  oligo

<400>  34
cacaattcag gtcaggtacc caacacccaa ctctcgactt ccac                        44


<210>  35
<211>  33
<212>  DNA
<213>  oligo

<400>  35
gggttgtaat gttacctatc actaatatag ctc                                    33


<210>  36
<211>  38
<212>  DNA
<213>  oligo

<400>  36
gcttaattat cattttttcc atttgtttaa tggtttac                               38


<210>  37
<211>  31
<212>  DNA
<213>  oligo

<400>  37
cgggtaagta aagaatcatt catacagttg g                                      31


<210>  38
<211>  24
<212>  DNA
<213>  oligo

<400>  38
ccgctaacac gcagttcgtc ttcc                                              24


<210>  39
<211>  30
<212>  DNA
<213>  oligo

<400>  39
cccttctgag actactaata tcagttcttg                                        30


<210>  40
<211>  30
<212>  DNA
<213>  oligo

<400>  40
ggaatcgagt cagcagttgt tatcaacggg                                        30


<210>  41
<211>  30
<212>  DNA
<213>  oligo

<400>  41
cccgttgata acaactgctg actcgattcc                                        30


<210>  42
<211>  28
<212>  DNA
<213>  oligo

<400>  42
ctgaatatgg aggcaatgtg ctctcatc                                          28


<210>  43
<211>  37
<212>  DNA
<213>  oligo

<400>  43
atgaagaata aagattatcc cttgaggtcg tctatgg                                37


<210>  44
<211>  46
<212>  DNA
<213>  oligo

<400>  44
taaaccagca ccgtcaccga cttcgctttc aacttccatt tccccc                      46


<210>  45
<211>  46
<212>  DNA
<213>  oligo

<400>  45
gggggaaatg gaagttgaaa gcgaagtcgg tgacggtgct ggttta                      46


<210>  46
<211>  42
<212>  DNA
<213>  oligo

<400>  46
aatataggag ctctggttaa gcatgtgatc ttcatacgac gc                          42


<210>  47
<211>  42
<212>  DNA
<213>  oligo

<400>  47
aatataggag ctcagaaatt cagtgtcatg tcagctacgc ag                          42


<210>  48
<211>  41
<212>  DNA
<213>  oligo

<400>  48
aatatagagc tcagaaattc agtgtcatgt cagctacgca g                           41


<210>  49
<211>  33
<212>  DNA
<213>  oligo

<400>  49
aatatagagc tccggggacg aggcaagcta aac                                    33


<210>  50
<211>  49
<212>  DNA
<213>  oligo

<400>  50
aatatagagc tcaatgcttc aaaataattt tgtaaatcat gttatgccg                   49


<210>  51
<211>  40
<212>  DNA
<213>  oligo

<400>  51
aatatagagc tctctatcac aaaaaaggtt gcagcggagc                             40


<210>  52
<211>  41
<212>  DNA
<213>  oligo

<400>  52
aatatagagc tccggctact gataattgcc ttgcactctt c                           41


<210>  53
<211>  44
<212>  DNA
<213>  oligo

<400>  53
aatatagagc tccgaattga gtttgtagga agaaacaaag ttcc                        44


<210>  54
<211>  44
<212>  DNA
<213>  oligo

<400>  54
aatatagagc tcggctcttc gatgcaaagt aaggtaagta gttg                        44


<210>  55
<211>  43
<212>  DNA
<213>  oligo

<400>  55
aatatagagc tccatctcta aacccgtatt tggtagaaac ggc                         43


<210>  56
<211>  43
<212>  DNA
<213>  oligo

<400>  56
aatatagagc tcccgaagta tcatatcaac gtagtacacc atg                         43


<210>  57
<211>  36
<212>  DNA
<213>  oligo

<400>  57
aatatagagc tcggaggcaa agccaaacgt tctagc                                 36


<210>  58
<211>  45
<212>  DNA
<213>  oligo

<400>  58
aatataggag ctctataata gatcacaaag gaaaactcgc cgcag                       45


<210>  59
<211>  48
<212>  DNA
<213>  oligo

<400>  59
aatataggag ctcctgcgta gcttacatgt tattgcgata acatttcg                    48


<210>  60
<211>  56
<212>  DNA
<213>  oligo

<400>  60
gtgtatatca ttcaataata gattgttttt aagaatagaa gaataaagat tatccc           56


<210>  61
<211>  56
<212>  DNA
<213>  oligo

<400>  61
gggataatct ttattcttct attcttaaaa acaatctatt attgaatgat atacac           56


<210>  62
<211>  43
<212>  DNA
<213>  oligo

<400>  62
aatatagagc tcgcgttatt aatgtagttg tcgctacagt tgg                         43


<210>  63
<211>  49
<212>  DNA
<213>  oligo

<400>  63
aatatagagc tccttcttat tcaccccaac ttagatttcc ttatgcatc                   49


<210>  64
<211>  72
<212>  DNA
<213>  oligo

<400>  64
ccaaatttca aaagttattt attttattat acctttcaga aatttggaaa tatattaaaa       60

ctgtatctga ag                                                           72


<210>  65
<211>  72
<212>  DNA
<213>  oligo

<400>  65
cttcagatac agttttaata tatttccaaa tttctgaaag gtataataaa ataaataact       60

tttgaaattt gg                                                           72


<210>  66
<211>  33
<212>  DNA
<213>  oligo

<400>  66
gtactcaatt catccttaag acgacctcaa ggg                                    33


<210>  67
<211>  32
<212>  DNA
<213>  oligo

<400>  67
cccttgaggt cgtcttagga tgaattgagt ac                                     32


<210>  68
<211>  30
<212>  DNA
<213>  oligo

<400>  68
aaatggaatg cccatcctga tcttaacttg                                        30


<210>  69
<211>  55
<212>  DNA
<213>  oligo

<400>  69
tccctacaac ctgtttttcg ctcatcgtga tgcaaaacta ctcttttcaa ttaga            55


<210>  70
<211>  60
<212>  DNA
<213>  oligo

<400>  70
aaagttggtt ggaaaaatta ttctgcatag agatgaattg gattatgtca ggaaaagaac       60


<210>  71
<211>  30
<212>  DNA
<213>  oligo

<400>  71
gtgaacgatt agggacgaat tatcaactgt                                        30


<210>  72
<211>  55
<212>  DNA
<213>  oligo

<400>  72
tctaattgaa aagagtagtt ttgcatcacg atgagcgaaa aacaggttgt aggga            55


<210>  73
<211>  60
<212>  DNA
<213>  oligo

<400>  73
gttcttttcc tgacataatc caattcatct ctatgcagaa taatttttcc aaccaacttt       60


<210>  74
<211>  21
<212>  DNA
<213>  oligo

<400>  74
taacgccgcc atccagtgtc g                                                 21


<210>  75
<211>  25
<212>  DNA
<213>  oligo

<400>  75
gccgaatatc gacttctcca acggg                                             25


<210>  76
<211>  34
<212>  DNA
<213>  oligo

<400>  76
gccctgttag acgaatttat gctcgtaata tgtc                                   34


