                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  THERAPEUTIC FORMULATIONS CONTAINING CD34+ STEM CELLS DERIVED FROM
        NEGATIVE SELECTION

<130>  F053-0064PCT/17-098-WO-PCT

<150>  US 62/491116
<151>  2017-04-27

<150>  US 62/503801
<151>  2017-05-09

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  175
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence for filgrastim

<400>  1

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  2
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  3
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  4
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 
65                  70                  75                  80  


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 
                85                  90                  95      


Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 
            100                 105                 110         


Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 
        115                 120                 125             


Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 
    130                 135                 140                 


Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 
145                 150                 155                 160 


Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170     


<210>  5
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  6
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  7
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  7
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa      420

gctctgttga ggaatgacca ggtctatcag cccctccgag atcgagatga tgctcagtac      480

agccaccttg gaggaaactg ggctcggaac aagtga                                516


<210>  8
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  8
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacccaga ctatgagccc atccggaaag gccagcggga cctgtattct      600

ggcctgaatc agagacgcat ctga                                             624


<210>  9
<211>  549
<212>  DNA
<213>  Homo sapiens

<400>  9
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga ccagctctac      480

cagcccctca aggatcgaga agatgaccag tacagccacc ttcaaggaaa ccagttgagg      540

aggaattga                                                              549


<210>  10
<211>  495
<212>  DNA
<213>  Homo sapiens

<400>  10
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctggatgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      240

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      300

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      360

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc      420

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc      480

ctgccccctc gctaa                                                       495


<210>  11
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  11
atggagcgcg cgtcctgctt gttgctgctg ctgctgccgc tggtgcacgt ctctgcgacc       60

acgccagaac cttgtgagct ggacgatgaa gatttccgct gcgtctgcaa cttctccgaa      120

cctcagcccg actggtccga agccttccag tgtgtgtctg cagtagaggt ggagatccat      180

gccggcggtc tcaacctaga gccgtttcta aagcgcgtcg atgcggacgc cgacccgcgg      240

cagtatgctg acacggtcaa ggctctccgc gtgcggcggc tcacagtggg agccgcacag      300

gttcctgctc agctactggt aggcgccctg cgtgtgctag cgtactcccg cctcaaggaa      360

ctgacgctcg aggacctaaa gataaccggc accatgcctc cgctgcctct ggaagccaca      420

ggacttgcac tttccagctt gcgcctacgc aacgtgtcgt gggcgacagg gcgttcttgg      480

ctcgccgagc tgcagcagtg gctcaagcca ggcctcaagg tactgagcat tgcccaagca      540

cactcgcctg ccttttcctg cgaacaggtt cgcgccttcc cggcccttac cagcctagac      600

ctgtctgaca atcctggact gggcgaacgc ggactgatgg cggctctctg tccccacaag      660

ttcccggcca tccagaatct agcgctgcgc aacacaggaa tggagacgcc cacaggcgtg      720

tgcgccgcac tggcggcggc aggtgtgcag ccccacagcc tagacctcag ccacaactcg      780

ctgcgcgcca ccgtaaaccc tagcgctccg agatgcatgt ggtccagcgc cctgaactcc      840

ctcaatctgt cgttcgctgg gctggaacag gtgcctaaag gactgccagc caagctcaga      900

gtgctcgatc tcagctgcaa cagactgaac agggcgccgc agcctgacga gctgcccgag      960

gtggataacc tgacactgga cgggaatccc ttcctggtcc ctggaactgc cctcccccac     1020

gagggctcaa tgaactccgg cgtggtccca gcctgtgcac gttcgaccct gtcggtgggg     1080

gtgtcgggaa ccctggtgct gctccaaggg gcccggggct ttgcctaa                  1128


<210>  12
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagggt gctcgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcgacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaagg caggaagtat tttcatcata attctgactt ctacattcca      480

aaagccacac tcaaagacag cggctcctac ttctgcaggg ggctttttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctttc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattc gaagctcaac aagagactgg      720

aaggaccata aatttaaatg gagaaaggac cctcaagaca aatga                      765


<210>  13
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  13
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagcgt gcttgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agaacctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcaacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaaga caggaagtat tttcatcata attctgactt ccacattcca      480

aaagccacac tcaaagatag cggctcctac ttctgcaggg ggcttgttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctctc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattt ga                         702


<210>  14
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  14
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac tgaccccacc aggagattct tcaaagtgac gcctccccca     1020

ggaagcgggc cccagaacca gtacgggaac gtgctgtctc tccccacacc cacctcaggc     1080

ctcggacgcg cccagcgttg ggccgcaggc ctggggggca ctgccccgtc ttatggaaac     1140

ccgagcagcg acgtccaggc ggatggagcc ttggggtccc ggagcccgcc gggagtgggc     1200

ccagaagaag aggaagggga gggctatgag gaacctgaca gtgaggagga ctccgagttc     1260

tatgagaacg actccaacct tgggcaggac cagctctccc aggatggcag cggctacgag     1320

aaccctgagg atgagcccct gggtcctgag gatgaagact ccttctccaa cgctgagtct     1380

tatgagaacg aggatgaaga gctgacccag ccggtcgcca ggacaatgga cttcctgagc     1440

cctcatgggt cagcctggga ccccagccgg gaagcaacct ccctggggtc ccagtcctat     1500

gaggatatga gaggaatcct gtatgcagcc ccccagctcc gctccattcg gggccagcct     1560

ggacccaatc atgaggaaga tgcagactct tatgagaaca tggataatcc cgatgggcca     1620

gacccagcct ggggaggagg gggccgcatg ggcacctgga gcaccaggtg a              1671


<210>  15
<211>  1158
<212>  DNA
<213>  Homo sapiens

<400>  15
atgctggtcc gcaggggcgc gcgcgcaggg cccaggatgc cgcggggctg gaccgcgctt       60

tgcttgctga gtttgctgcc ttctgggttc atgagtcttg acaacaacgg tactgctacc      120

ccagagttac ctacccaggg aacattttca aatgtttcta caaatgtatc ctaccaagaa      180

actacaacac ctagtaccct tggaagtacc agcctgcacc ctgtgtctca acatggcaat      240

gaggccacaa caaacatcac agaaacgaca gtcaaattca catctacctc tgtgataacc      300

tcagtttatg gaaacacaaa ctcttctgtc cagtcacaga cctctgtaat cagcacagtg      360

ttcaccaccc cagccaacgt ttcaactcca gagacaacct tgaagcctag cctgtcacct      420

ggaaatgttt cagacctttc aaccactagc actagccttg caacatctcc cactaaaccc      480

tatacatcat cttctcctat cctaagtgac atcaaggcag aaatcaaatg ttcaggcatc      540

agagaagtga aattgactca gggcatctgc ctggagcaaa ataagacctc cagctgtgcg      600

gagtttaaga aggacagggg agagggcctg gcccgagtgc tgtgtgggga ggagcaggct      660

gatgctgatg ctggggccca ggtatgctcc ctgctccttg cccagtctga ggtgaggcct      720

cagtgtctac tgctggtctt ggccaacaga acagaaattt ccagcaaact ccaacttatg      780

aaaaagcacc aatctgacct gaaaaagctg gggatcctag atttcactga gcaagatgtt      840

gcaagccacc agagctattc ccaaaagacc ctgattgcac tggtcacctc gggagccctg      900

ctggctgtct tgggcatcac tggctatttc ctgatgaatc gccgcagctg gagccccaca      960

ggagaaaggc tgggcgaaga cccttattac acggaaaacg gtggaggcca gggctatagc     1020

tcaggacctg ggacctcccc tgaggctcag ggaaaggcca gtgtgaaccg aggggctcag     1080

gaaaacggga ccggccaggc cacctccaga aacggccatt cagcaagaca acacgtggtg     1140

gctgataccg aattgtga                                                   1158


<210>  16
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  16
atgctggtcc gcaggggcgc gcgcgcaggg cccaggatgc cgcggggctg gaccgcgctt       60

tgcttgctga gtttgctgcc ttctgggttc atgagtcttg acaacaacgg tactgctacc      120

ccagagttac ctacccaggg aacattttca aatgtttcta caaatgtatc ctaccaagaa      180

actacaacac ctagtaccct tggaagtacc agcctgcacc ctgtgtctca acatggcaat      240

gaggccacaa caaacatcac agaaacgaca gtcaaattca catctacctc tgtgataacc      300

tcagtttatg gaaacacaaa ctcttctgtc cagtcacaga cctctgtaat cagcacagtg      360

ttcaccaccc cagccaacgt ttcaactcca gagacaacct tgaagcctag cctgtcacct      420

ggaaatgttt cagacctttc aaccactagc actagccttg caacatctcc cactaaaccc      480

tatacatcat cttctcctat cctaagtgac atcaaggcag aaatcaaatg ttcaggcatc      540

agagaagtga aattgactca gggcatctgc ctggagcaaa ataagacctc cagctgtgcg      600

gagtttaaga aggacagggg agagggcctg gcccgagtgc tgtgtgggga ggagcaggct      660

gatgctgatg ctggggccca ggtatgctcc ctgctccttg cccagtctga ggtgaggcct      720

cagtgtctac tgctggtctt ggccaacaga acagaaattt ccagcaaact ccaacttatg      780

aaaaagcacc aatctgacct gaaaaagctg gggatcctag atttcactga gcaagatgtt      840

gcaagccacc agagctattc ccaaaagacc ctgattgcac tggtcacctc gggagccctg      900

ctggctgtct tgggcatcac tggctatttc ctgatgaatc gccgcagctg gagccccaca      960

ggagaaaggc tggagctgga accctga                                          987


<210>  17
<211>  3921
<212>  DNA
<213>  Homo sapiens

<400>  17
atgaccatgt atttgtggct taaactcttg gcatttggct ttgcctttct ggacacagaa       60

gtatttgtga cagggcaaag cccaacacct tcccccactg gattgactac agcaaagatg      120

cccagtgttc cactttcaag tgacccctta cctactcaca ccactgcatt ctcacccgca      180

agcacctttg aaagagaaaa tgacttctca gagaccacaa cttctcttag tccagacaat      240

acttccaccc aagtatcccc ggactctttg gataatgcta gtgcttttaa taccacaggt      300

gtttcatcag tacagacgcc tcaccttccc acgcacgcag actcgcagac gccctctgct      360

ggaactgaca cgcagacatt cagcggctcc gccgccaatg caaaactcaa ccctacccca      420

ggcagcaatg ctatctcaga tgtcccagga gagaggagta cagccagcac ctttcctaca      480

gacccagttt ccccattgac aaccaccctc agccttgcac accacagctc tgctgcctta      540

cctgcacgca cctccaacac caccatcaca gcgaacacct cagatgccta ccttaatgcc      600

tctgaaacaa ccactctgag cccttctgga agcgctgtca tttcaaccac aacaatagct      660

actactccat ctaagccaac atgtgatgaa aaatatgcaa acatcactgt ggattactta      720

tataacaagg aaactaaatt atttacagca aagctaaatg ttaatgagaa tgtggaatgt      780

ggaaacaata cttgcacaaa caatgaggtg cataacctta cagaatgtaa aaatgcgtct      840

gtttccatat ctcataattc atgtactgct cctgataaga cattaatatt agatgtgcca      900

ccaggggttg aaaagtttca gttacatgat tgtacacaag ttgaaaaagc agatactact      960

atttgtttaa aatggaaaaa tattgaaacc tttacttgtg atacacagaa tattacctac     1020

agatttcagt gtggtaatat gatatttgat aataaagaaa ttaaattaga aaaccttgaa     1080

cccgaacatg agtataagtg tgactcagaa atactctata ataaccacaa gtttactaac     1140

gcaagtaaaa ttattaaaac agattttggg agtccaggag agcctcagat tattttttgt     1200

agaagtgaag ctgcacatca aggagtaatt acctggaatc cccctcaaag atcatttcat     1260

aattttaccc tctgttatat aaaagagaca gaaaaagatt gcctcaatct ggataaaaac     1320

ctgatcaaat atgatttgca aaatttaaaa ccttatacga aatatgtttt atcattacat     1380

gcctacatca ttgcaaaagt gcaacgtaat ggaagtgctg caatgtgtca tttcacaact     1440

aaaagtgctc ctccaagcca ggtctggaac atgactgtct ccatgacatc agataatagt     1500

atgcatgtca agtgtaggcc tcccagggac cgtaatggcc cccatgaacg ttaccatttg     1560

gaagttgaag ctggaaatac tctggttaga aatgagtcgc ataagaattg cgatttccgt     1620

gtaaaagatc ttcaatattc aacagactac acttttaagg cctattttca caatggagac     1680

tatcctggag aaccctttat tttacatcat tcaacatctt ataattctaa ggcactgata     1740

gcatttctgg catttctgat tattgtgaca tcaatagccc tgcttgttgt tctctacaaa     1800

atctatgatc tacataagaa aagatcctgc aatttagatg aacagcagga gcttgttgaa     1860

agggatgatg aaaaacaact gatgaatgtg gagccaatcc atgcagatat tttgttggaa     1920

acttataaga ggaagattgc tgatgaagga agactttttc tggctgaatt tcagagcatc     1980

ccgcgggtgt tcagcaagtt tcctataaag gaagctcgaa agccctttaa ccagaataaa     2040

aaccgttatg ttgacattct tccttatgat tataaccgtg ttgaactctc tgagataaac     2100

ggagatgcag ggtcaaacta cataaatgcc agctatattg atggtttcaa agaacccagg     2160

aaatacattg ctgcacaagg tcccagggat gaaactgttg atgatttctg gaggatgatt     2220

tgggaacaga aagccacagt tattgtcatg gtcactcgat gtgaagaagg aaacaggaac     2280

aagtgtgcag aatactggcc gtcaatggaa gagggcactc gggcttttgg agatgttgtt     2340

gtaaagatca accagcacaa aagatgtcca gattacatca ttcagaaatt gaacattgta     2400

aataaaaaag aaaaagcaac tggaagagag gtgactcaca ttcagttcac cagctggcca     2460

gaccacgggg tgcctgagga tcctcacttg ctcctcaaac tgagaaggag agtgaatgcc     2520

ttcagcaatt tcttcagtgg tcccattgtg gtgcactgca gtgctggtgt tgggcgcaca     2580

ggaacctata tcggaattga tgccatgcta gaaggcctgg aagccgagaa caaagtggat     2640

gtttatggtt atgttgtcaa gctaaggcga cagagatgcc tgatggttca agtagaggcc     2700

cagtacatct tgatccatca ggctttggtg gaatacaatc agtttggaga aacagaagtg     2760

aatttgtctg aattacatcc atatctacat aacatgaaga aaagggatcc acccagtgag     2820

ccgtctccac tagaggctga attccagaga cttccttcat ataggagctg gaggacacag     2880

cacattggaa atcaagaaga aaataaaagt aaaaacagga attctaatgt catcccatat     2940

gactataaca gagtgccact taaacatgag ctggaaatga gtaaagagag tgagcatgat     3000

tcagatgaat cctctgatga tgacagtgat tcagaggaac caagcaaata catcaatgca     3060

tcttttataa tgagctactg gaaacctgaa gtgatgattg ctgctcaggg accactgaag     3120

gagaccattg gtgacttttg gcagatgatc ttccaaagaa aagtcaaagt tattgttatg     3180

ctgacagaac tgaaacatgg agaccaggaa atctgtgctc agtactgggg agaaggaaag     3240

caaacatatg gagatattga agttgacctg aaagacacag acaaatcttc aacttatacc     3300

cttcgtgtct ttgaactgag acattccaag aggaaagact ctcgaactgt gtaccagtac     3360

caatatacaa actggagtgt ggagcagctt cctgcagaac ccaaggaatt aatctctatg     3420

attcaggtcg tcaaacaaaa acttccccag aagaattcct ctgaagggaa caagcatcac     3480

aagagtacac ctctactcat tcactgcagg gatggatctc agcaaacggg aatattttgt     3540

gctttgttaa atctcttaga aagtgcggaa acagaagagg tagtggatat ttttcaagtg     3600

gtaaaagctc tacgcaaagc taggccaggc atggtttcca cattcgagca atatcaattc     3660

ctatatgacg tcattgccag cacctaccct gctcagaatg gacaagtaaa gaaaaacaac     3720

catcaagaag ataaaattga atttgataat gaagtggaca aagtaaagca ggatgctaat     3780

tgtgttaatc cacttggtgc cccagaaaag ctccctgaag caaaggaaca ggctgaaggt     3840

tctgaaccca cgagtggcac tgaggggcca gaacattctg tcaatggtcc tgcaagtcca     3900

gctttaaatc aaggttcata g                                               3921


<210>  18
<211>  3438
<212>  DNA
<213>  Homo sapiens

<400>  18
atgaccatgt atttgtggct taaactcttg gcatttggct ttgcctttct ggacacagaa       60

gtatttgtga cagggcaaag cccaacacct tcccccactg atgcctacct taatgcctct      120

gaaacaacca ctctgagccc ttctggaagc gctgtcattt caaccacaac aatagctact      180

actccatcta agccaacatg tgatgaaaaa tatgcaaaca tcactgtgga ttacttatat      240

aacaaggaaa ctaaattatt tacagcaaag ctaaatgtta atgagaatgt ggaatgtgga      300

aacaatactt gcacaaacaa tgaggtgcat aaccttacag aatgtaaaaa tgcgtctgtt      360

tccatatctc ataattcatg tactgctcct gataagacat taatattaga tgtgccacca      420

ggggttgaaa agtttcagtt acatgattgt acacaagttg aaaaagcaga tactactatt      480

tgtttaaaat ggaaaaatat tgaaaccttt acttgtgata cacagaatat tacctacaga      540

tttcagtgtg gtaatatgat atttgataat aaagaaatta aattagaaaa ccttgaaccc      600

gaacatgagt ataagtgtga ctcagaaata ctctataata accacaagtt tactaacgca      660

agtaaaatta ttaaaacaga ttttgggagt ccaggagagc ctcagattat tttttgtaga      720

agtgaagctg cacatcaagg agtaattacc tggaatcccc ctcaaagatc atttcataat      780

tttaccctct gttatataaa agagacagaa aaagattgcc tcaatctgga taaaaacctg      840

atcaaatatg atttgcaaaa tttaaaacct tatacgaaat atgttttatc attacatgcc      900

tacatcattg caaaagtgca acgtaatgga agtgctgcaa tgtgtcattt cacaactaaa      960

agtgctcctc caagccaggt ctggaacatg actgtctcca tgacatcaga taatagtatg     1020

catgtcaagt gtaggcctcc cagggaccgt aatggccccc atgaacgtta ccatttggaa     1080

gttgaagctg gaaatactct ggttagaaat gagtcgcata agaattgcga tttccgtgta     1140

aaagatcttc aatattcaac agactacact tttaaggcct attttcacaa tggagactat     1200

cctggagaac cctttatttt acatcattca acatcttata attctaaggc actgatagca     1260

tttctggcat ttctgattat tgtgacatca atagccctgc ttgttgttct ctacaaaatc     1320

tatgatctac ataagaaaag atcctgcaat ttagatgaac agcaggagct tgttgaaagg     1380

gatgatgaaa aacaactgat gaatgtggag ccaatccatg cagatatttt gttggaaact     1440

tataagagga agattgctga tgaaggaaga ctttttctgg ctgaatttca gagcatcccg     1500

cgggtgttca gcaagtttcc tataaaggaa gctcgaaagc cctttaacca gaataaaaac     1560

cgttatgttg acattcttcc ttatgattat aaccgtgttg aactctctga gataaacgga     1620

gatgcagggt caaactacat aaatgccagc tatattgatg gtttcaaaga acccaggaaa     1680

tacattgctg cacaaggtcc cagggatgaa actgttgatg atttctggag gatgatttgg     1740

gaacagaaag ccacagttat tgtcatggtc actcgatgtg aagaaggaaa caggaacaag     1800

tgtgcagaat actggccgtc aatggaagag ggcactcggg cttttggaga tgttgttgta     1860

aagatcaacc agcacaaaag atgtccagat tacatcattc agaaattgaa cattgtaaat     1920

aaaaaagaaa aagcaactgg aagagaggtg actcacattc agttcaccag ctggccagac     1980

cacggggtgc ctgaggatcc tcacttgctc ctcaaactga gaaggagagt gaatgccttc     2040

agcaatttct tcagtggtcc cattgtggtg cactgcagtg ctggtgttgg gcgcacagga     2100

acctatatcg gaattgatgc catgctagaa ggcctggaag ccgagaacaa agtggatgtt     2160

tatggttatg ttgtcaagct aaggcgacag agatgcctga tggttcaagt agaggcccag     2220

tacatcttga tccatcaggc tttggtggaa tacaatcagt ttggagaaac agaagtgaat     2280

ttgtctgaat tacatccata tctacataac atgaagaaaa gggatccacc cagtgagccg     2340

tctccactag aggctgaatt ccagagactt ccttcatata ggagctggag gacacagcac     2400

attggaaatc aagaagaaaa taaaagtaaa aacaggaatt ctaatgtcat cccatatgac     2460

tataacagag tgccacttaa acatgagctg gaaatgagta aagagagtga gcatgattca     2520

gatgaatcct ctgatgatga cagtgattca gaggaaccaa gcaaatacat caatgcatct     2580

tttataatga gctactggaa acctgaagtg atgattgctg ctcagggacc actgaaggag     2640

accattggtg acttttggca gatgatcttc caaagaaaag tcaaagttat tgttatgctg     2700

acagaactga aacatggaga ccaggaaatc tgtgctcagt actggggaga aggaaagcaa     2760

acatatggag atattgaagt tgacctgaaa gacacagaca aatcttcaac ttataccctt     2820

cgtgtctttg aactgagaca ttccaagagg aaagactctc gaactgtgta ccagtaccaa     2880

tatacaaact ggagtgtgga gcagcttcct gcagaaccca aggaattaat ctctatgatt     2940

caggtcgtca aacaaaaact tccccagaag aattcctctg aagggaacaa gcatcacaag     3000

agtacacctc tactcattca ctgcagggat ggatctcagc aaacgggaat attttgtgct     3060

ttgttaaatc tcttagaaag tgcggaaaca gaagaggtag tggatatttt tcaagtggta     3120

aaagctctac gcaaagctag gccaggcatg gtttccacat tcgagcaata tcaattccta     3180

tatgacgtca ttgccagcac ctaccctgct cagaatggac aagtaaagaa aaacaaccat     3240

caagaagata aaattgaatt tgataatgaa gtggacaaag taaagcagga tgctaattgt     3300

gttaatccac ttggtgcccc agaaaagctc cctgaagcaa aggaacaggc tgaaggttct     3360

gaacccacga gtggcactga ggggccagaa cattctgtca atggtcctgc aagtccagct     3420

ttaaatcaag gttcatag                                                   3438


<210>  19
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  20
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  21
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  22
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  23
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  24
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  25
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             


<210>  26
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  27
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  28
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Glu Leu Glu Pro 
                325             


<210>  29
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


<210>  30
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  31
<211>  4368
<212>  DNA
<213>  Homo sapiens

<400>  31
atgtccgact cgtgggtccc gaactccgcc tcgggccagg acccaggggg ccgccggagg       60

gcctgggccg agctgctggc gggaagggtc aagagggaaa aatataatcc tgaaagggca      120

cagaaattaa aggaatcagc tgtgcgcctc ctgcgaagcc atcaggacct gaatgccctt      180

ttgcttgagg tagaaggtcc actgtgtaaa aaattgtctc tcagcaaagt gattgactgt      240

gacagttctg aggcctatgc taatcattct agttcattta taggctctgc tttgcaggat      300

caagcctcaa ggctgggggt tcccgtgggt attctctcag ccgggatggt tgcctctagc      360

gtgggacaga tctgcacggc tccagcggag accagtcacc ctgtgctgct gactgtggag      420

cagagaaaga agctgtcttc cctgttagag tttgctcagt atttattggc acacagtatg      480

ttctcccgtc tttccttctg tcaagaatta tggaaaatac agagttcttt gttgcttgaa      540

gcggtgtggc atcttcacgt acaaggcatt gtgagcctgc aagagctgct ggaaagccat      600

cccgacatgc atgctgtggg atcgtggctc ttcaggaatc tgtgctgcct ttgtgaacag      660

atggaagcat cctgccagca tgctgacgtc gccagggcca tgctttctga ttttgttcaa      720

atgtttgttt tgaggggatt tcagaaaaac tcagatctga gaagaactgt ggagcctgaa      780

aaaatgccgc aggtcacggt tgatgtactg cagagaatgc tgatttttgc acttgacgct      840

ttggctgctg gagtacagga ggagtcctcc actcacaaga tcgtgaggtg ctggttcgga      900

gtgttcagtg gacacacgct tggcagtgta atttccacag atcctctgaa gaggttcttc      960

agtcataccc tgactcagat actcactcac agccctgtgc tgaaagcatc tgatgctgtt     1020

cagatgcaga gagagtggag ctttgcgcgg acacaccctc tgctcacctc actgtaccgc     1080

aggctctttg tgatgctgag tgcagaggag ttggttggcc atttgcaaga agttctggaa     1140

acgcaggagg ttcactggca gagagtgctc tcctttgtgt ctgccctggt tgtctgcttt     1200

ccagaagcgc agcagctgct tgaagactgg gtggcgcgtt tgatggccca ggcattcgag     1260

agctgccagc tggacagcat ggtcactgcg ttcctggttg tgcgccaggc agcactggag     1320

ggcccctctg cgttcctgtc atatgcagac tggttcaagg cctcctttgg gagcacacga     1380

ggctaccatg gctgcagcaa gaaggccctg gtcttcctgt ttacgttctt gtcagaactc     1440

gtgccttttg agtctccccg gtacctgcag gtgcacattc tccacccacc cctggttccc     1500

agcaagtacc gctccctcct cacagactac atctcattgg ccaagacacg gctggccgac     1560

ctcaaggttt ctatagaaaa catgggactc tacgaggatt tgtcatcagc tggggacatt     1620

actgagcccc acagccaagc tcttcaggat gttgaaaagg ccatcatggt gtttgagcat     1680

acggggaaca tcccagtcac cgtcatggag gccagcatat tcaggaggcc ttactacgtg     1740

tcccacttcc tccccgccct gctcacacct cgagtgctcc ccaaagtccc tgactcccgt     1800

gtggcgttta tagagtctct gaagagagca gataaaatcc ccccatctct gtactccacc     1860

tactgccagg cctgctctgc tgctgaagag aagccagaag atgcagccct gggagtgagg     1920

gcagaaccca actctgctga ggagcccctg ggacagctca cagctgcact gggagagctg     1980

agagcctcca tgacagaccc cagccagcgt gatgttatat cggcacaggt ggcagtgatt     2040

tctgaaagac tgagggctgt cctgggccac aatgaggatg acagcagcgt tgagatatca     2100

aagattcagc tcagcatcaa cacgccgaga ctggagccac gggaacacat tgctgtggac     2160

ctcctgctga cgtctttctg tcagaacctg atggctgcct ccagtgtcgc tcccccggag     2220

aggcagggtc cctgggctgc cctcttcgtg aggaccatgt gtggacgtgt gctccctgca     2280

gtgctcaccc ggctctgcca gctgctccgt caccagggcc cgagcctgag tgccccacat     2340

gtgctggggt tggctgccct ggccgtgcac ctgggtgagt ccaggtctgc gctcccagag     2400

gtggatgtgg gtcctcctgc acctggtgct ggccttcctg tccctgcgct ctttgacagc     2460

ctcctgacct gtaggacgag ggattccttg ttcttctgcc tgaaattttg tacagcagca     2520

atttcttact ctctctgcaa gttttcttcc cagtcacgag atactttgtg cagctgctta     2580

tctccaggcc ttattaaaaa gtttcagttc ctcatgttca gattgttctc agaggcccga     2640

cagcctcttt ctgaggagga cgtagccagc ctttcctgga gacccttgca ccttccttct     2700

gcagactggc agagagctgc cctctctctc tggacacaca gaaccttccg agaggtgttg     2760

aaagaggaag atgttcactt aacttaccaa gactggttac acctggagct ggaaattcaa     2820

cctgaagctg atgctctttc agatactgaa cggcaggact tccaccagtg ggcgatccat     2880

gagcactttc tccctgagtc ctcggcttca gggggctgtg acggagacct gcaggctgcg     2940

tgtaccattc ttgtcaacgc actgatggat ttccaccaaa gctcaaggag ttatgaccac     3000

tcagaaaatt ctgatttggt ctttggtggc cgcacaggaa atgaggatat tatttccaga     3060

ttgcaggaga tggtagctga cctggagctg cagcaagacc tcatagtgcc tctcggccac     3120

accccttccc aggagcactt cctctttgag attttccgca gacggctcca ggctctgaca     3180

agcgggtgga gcgtggctgc cagccttcag agacagaggg agctgctaat gtacaaacgg     3240

atcctcctcc gcctgccttc gtctgtcctc tgcggcagca gcttccaggc agaacagccc     3300

atcactgcca gatgcgagca gttcttccac ttggtcaact ctgagatgag aaacttctgc     3360

tcccacggag gtgccctgac acaggacatc actgcccact tcttcagggg cctcctgaac     3420

gcctgtctgc ggagcagaga cccctccctg atggtcgact tcatactggc caagtgccag     3480

acgaaatgcc ccttaatttt gacctctgct ctggtgtggt ggccgagcct ggagcctgtg     3540

ctgctctgcc ggtggaggag acactgccag agcccgctgc cccgggaact gcagaagcta     3600

caagaaggcc ggcagtttgc cagcgatttc ctctcccctg aggctgcctc cccagcaccc     3660

aacccggact ggctctcagc tgctgcactg cactttgcga ttcaacaagt cagggaagaa     3720

aacatcagga agcagctaaa gaagctggac tgcgagagag aggagctatt ggttttcctt     3780

ttcttcttct ccttgatggg cctgctgtcg tcacatctga cctcaaatag caccacagac     3840

ctgccaaagg ctttccacgt ttgtgcagca atcctcgagt gtttagagaa gaggaagata     3900

tcctggctgg cactctttca gttgacagag agtgacctca ggctggggcg gctcctcctc     3960

cgtgtggccc cggatcagca caccaggctg ctgcctttcg ctttttacag tcttctctcc     4020

tacttccatg aagacgcggc catcagggaa gaggccttcc tgcatgttgc tgtggacatg     4080

tacttgaagc tggtccagct cttcgtggct ggggatacaa gcacagtttc acctccagct     4140

ggcaggagcc tggagctcaa gggtcagggc aaccccgtgg aactgataac aaaagctcgt     4200

ctttttctgc tgcagttaat acctcggtgc ccgaaaaaga gcttctcaca cgtggcagag     4260

ctgctggctg atcgtgggga ctgcgaccca gaggtgagcg ccgccctcca gagcagacag     4320

caggctgccc ctgacgctga cctgtcccag gagcctcatc tcttctga                  4368


<210>  32
<211>  1677
<212>  DNA
<213>  Homo sapiens

<400>  32
atggctcaag attcagtaga tctttcttgt gattatcagt tttggatgca gaagctttct       60

gtatgggatc aggcttccac tttggaaacc cagcaagaca cctgtcttca cgtggctcag      120

ttccaggagt tcctaaggaa gatgtatgaa gccttgaaag agatggattc taatacagtc      180

attgaaagat tccccacaat tggtcaactg ttggcaaaag cttgttggaa tccttttatt      240

ttagcatatg atgaaagcca aaaaattcta atatggtgct tatgttgtct aattaacaaa      300

gaaccacaga attctggaca atcaaaactt aactcctgga tacagggtgt attatctcat      360

atactttcag cactcagatt tgataaagaa gttgctcttt tcactcaagg tcttgggtat      420

gcacctatag attactatcc tggtttgctt aaaaatatgg ttttatcatt agcgtctgaa      480

ctcagagaga atcatcttaa tggatttaac actcaaaggc gaatggctcc cgagcgagtg      540

gcgtccctgt cacgagtttg tgtcccactt attaccctga cagatgttga ccccctggtg      600

gaggctctcc tcatctgtca tggacgtgaa cctcaggaaa tcctccagcc agagttcttt      660

gaggctgtaa acgaggccat tttgctgaag aagatttctc tccccatgtc agctgtagtc      720

tgcctctggc ttcggcacct tcccagcctt gaaaaagcaa tgctgcatct ttttgaaaag      780

ctaatctcca gtgagagaaa ttgtctgaga aggatcgaat gctttataaa agattcatcg      840

ctgcctcaag cagcctgcca ccctgccata ttccgggttg ttgatgagat gttcaggtgt      900

gcactcctgg aaaccgatgg ggccctggaa atcatagcca ctattcaggt gtttacgcag      960

tgctttgtag aagctctgga gaaagcaagc aagcagctgc ggtttgcact caagacctac     1020

tttccttaca cttctccatc tcttgccatg gtgctgctgc aagaccctca agatatccct     1080

cggggacact ggctccagac actgaagcat atttctgaac tgctcagaga agcagttgaa     1140

gaccagactc atgggtcctg cggaggtccc tttgagagct ggttcctgtt cattcacttc     1200

ggaggatggg ctgagatggt ggcagagcaa ttactgatgt cggcagccga accccccacg     1260

gccctgctgt ggctcttggc cttctactac ggcccccgtg atgggaggca gcagagagca     1320

cagactatgg tccaggtgaa ggccgtgctg ggccacctcc tggcaatgtc cagaagcagc     1380

agcctctcag cccaggacct gcagacggta gcaggacagg gcacagacac agacctcaga     1440

gctcctgcac aacagctgat caggcacctt ctcctcaact tcctgctctg ggctcctgga     1500

ggccacacga tcgcctggga tgtcatcacc ctgatggctc acactgctga gataactcac     1560

gagatcattg gctttcttga ccagaccttg tacagatgga atcgtcttgg cattgaaagc     1620

cctagatcag aaaaactggc ccgagagctc cttaaagagc tgcgaactca agtctag        1677


<210>  33
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  33
atggcgacac cggacgcggg gctccctggg gctgagggcg tggagccggc gccctgggcg       60

cagctggagg cccccgcccg cctcctgctg caggcgctgc aggcggggcc tgagggggcg      120

cggcgcggcc tgggggtgct ccgggcgctg ggcagccgcg gctgggagcc cttcgactgg      180

ggtcgcttgc tcgaggccct gtgccgggag gagccggtcg tgcaggggcc tgacggccgt      240

ctggagctga aaccactgtt gctgcgattg ccccggatat gccagaggaa cctgatgtcc      300

ctgctgatgg ccgttcggcc atcgctgccg gaaagtgggc tcctctctgt gctgcagatt      360

gcccagcagg acctagcccc tgacccagat gcctggctcc gtgccctggg ggaattgctg      420

cgaagggatt tgggggtggg gacctccatg gagggagctt ctccactgtc tgaaagatgc      480

cagagacagc tccaaagtct atgtaggggg ctgggcctgg ggggcaggag gttgaaatcc      540

ccccaggctc cagaccctga agaagaggag aacagggact cccagcagcc tgggaaacgc      600

agaaaggact cagaggaaga ggctgccagt cctgagggga agagggtccc caaaagatta      660

cggtgttggg aagaggaaga agatcatgag aaggagagac ccgaacataa gtcactggaa      720

tccctggcag atggaggaag tgcatctcct attaaggacc agcctgtcat ggcagttaag      780

actggcgagg acggttcgaa tctggatgat gctaaaggtc tggctgagag tttggagttg      840

cccaaagcta tccaggacca gcttcccagg ctgcagcagc tgctgaagac cttggaggag      900

gggttagagg gattggagga tgccccccca gttgagctac agcttcttca cgaatgtagt      960

cccagccaga tggacttgct gtgtgcccag ctgcagctcc ctcagctctc agacctcggt     1020

ctcctgcggc tctgcacctg gctgctggcc ctttcacctg atctcagcct cagcaatgct     1080

actgtgctga ccagaagcct ctttcttgga cggatcctct ccttgacttc ctcagcctcc     1140

cgcctgctta caactgccct gacctccttc tgtgccaaat atacataccc tgtctgcagc     1200

gccctccttg accctgtgct ccaggcccca ggcacaggtc ctgctcaaac agagttactg     1260

tgttgccttg tgaagatgga gtccctggag ccagatgcac aggttctaat gctgggacag     1320

atcttggagc tgccctggaa ggaggaaact ttcttggtgt tgcagtcact cctagagcgg     1380

caggtggaga tgacccctga gaagttcagt gtcttaatgg agaagctctg taaaaagggg     1440

ctggcagcca ccacctccat ggcctatgcc aagctcatgc tgacagtgat gaccaagtat     1500

caggctaaca tcactgagac ccagaggctg ggcctggcta tggccctaga acctaacacc     1560

accttcctga ggaagtccct gaaggccgcc ttgaaacatt tgggcccctg a              1611


<210>  34
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  34
atggaatccc ttctgcagca cctggatcgc ttttccgagc ttctggcggt ctcaagcact       60

acctacgtca gcacctggga ccccgccacc gtgcgccggg ccttgcagtg ggcgcgctac      120

ctgcgccaca tccatcggcg ctttggtcgg catggcccca ttcgcacggc tctggagcgg      180

cggctgcaca accagtggag gcaagagggc ggctttgggc ggggtccagt tccgggatta      240

gcgaacttcc aggccctcgg tcactgtgac gtcctgctct ctctgcgcct gctggagaac      300

cgggccctcg gggatgcagc tcgttaccac ctggtgcagc aactctttcc cggcccgggc      360

gtccgggacg ccgatgagga gacactccaa gagagcctgg cccgccttgc ccgccggcgg      420

tctgcggtgc acatgctgcg cttcaatggc tatagagaga acccaaatct ccaggaggac      480

tctctgatga agacccaggc ggagctgctg ctggagcgtc tgcaggaggt ggggaaggcc      540

gaagcggagc gtcccgccag gtttctcagc agcctgtggg agcgcttgcc tcagaacaac      600

ttcctgaagg tgatagcggt ggcgctgttg cagccgcctt tgtctcgtcg gccccaagaa      660

gagttggaac ccggcatcca caaatcacct ggagagggga gccaagtgct agtccactgg      720

cttctgggga attcggaagt ctttgctgcc ttttgtcgcg ccctcccagc cgggcttttg      780

actttagtga ctagccgcca cccagcgctg tctcctgtct atctgggtct gctaacagac      840

tggggtcaac gtttgcacta tgaccttcag aaaggcattt gggttggaac tgagtcccaa      900

gatgtgccct gggaggagtt gcacaatagg tttcaaagcc tctgtcaggc ccctccacct      960

ctgaaagata aagttctaac tgccctggag acctgtaaag cgcaggatgg agattttgaa     1020

gtacctggtc ttagcatctg gacagacctc ttattagctc ttcgtagtgg tgcatttagg     1080

aaaagacaag ttttgggtct cagcgcaggc ctcagttctg tatag                     1125


<210>  35
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  35
atgtcccgcc agaccacctc tgtgggctcc agctgcctgg acctgtggag ggaaaagaat       60

gaccggctcg ttcgacaggc caaggtggct cagaactccg gtctgactct gaggcgacag      120

cagttggctc aggatgcact ggaagggctc agagggctcc tccatagtct gcaagggctc      180

cctgcagctg ttcctgttct tcccttggag ctgactgtca cctgcaactt cattatcctg      240

agggcaagct tggcccaggg tttcacagag gatcaggccc aggatatcca gcggagccta      300

gagagagtgc tggagacaca ggagcagcag gggcccaggt tggaacaggg gctcagggag      360

ctgtgggact ctgtccttcg tgcttcctgc cttctgccgg agctgctgtc tgccctgcac      420

cgcctggttg gcctgcaggc tgccctctgg ttgagtgctg accgtcttgg ggacctggcc      480

ttgttactag agaccctgaa tggcagccag agtggagcct ctaaggatct gctgttactt      540

ctgaaaactt ggagtccccc agctgaggaa ttagatgctc cattgaccct gcaggatgcc      600

cagggattga aggatgtcct cctgacagca tttgcctacc gccaaggtct ccaggagctg      660

atcacaggga acccagacaa ggcactaagc agccttcatg aagcggcctc aggcctgtgt      720

ccacggcctg tgttggtcca ggtgtacaca gcactggggt cctgtcaccg taagatggga      780

aatccacaga gagcactgtt gtacttggtt gcagccctga aagagggatc agcctggggt      840

cctccacttc tggaggcctc taggctctat cagcaactgg gggacacaac agcagagctg      900

gagagtctgg agctgctagt tgaggccttg aatgtcccat gcagttccaa agccccgcag      960

tttctcattg aggtagaatt actactgcca ccacctgacc tagcctcacc ccttcattgt     1020

ggcactcaga gccagaccaa gcacatacta gcaagcaggt gcctacagac ggggagggca     1080

ggagacgctg cagagcatta cttggacctg ctggccctgt tgctggatag ctcggagcca     1140

aggttctccc cacccccctc ccctccaggg ccctgtatgc ctgaggtgtt tttggaggca     1200

gcggtagcac tgatccaggc aggcagagcc caagatgcct tgactctatg tgaggagttg     1260

ctcagccgca catcatctct gctacccaag atgtcccggc tgtgggaaga tgccagaaaa     1320

ggaaccaagg aactgccata ctgcccactc tgggtctctg ccacccacct gcttcagggc     1380

caggcctggg ttcaactggg tgcccaaaaa gtggcaatta gtgaatttag caggtgcctc     1440

gagctgctct tccgggccac acctgaggaa aaagaacaag gggcagcttt caactgtgag     1500

cagggatgta agtcagatgc ggcactgcag cagcttcggg cagccgccct aattagtcgt     1560

ggactggaat gggtagccag cggccaggat accaaagcct tacaggactt cctcctcagt     1620

gtgcagatgt gcccaggtaa tcgagacact tactttcacc tgcttcagac tctgaagagg     1680

ctagatcgga gggatgaggc cactgcactc tggtggaggc tggaggccca aactaagggg     1740

tcacatgaag atgctctgtg gtctctcccc ctgtacctag aaagctattt gagctggatc     1800

cgtccctctg atcgtgacgc cttccttgaa gaatttcgga catctctgcc aaagtcttgt     1860

gacctgtag                                                             1869


<210>  36
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly 
1               5                   10                  15      


Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg 
            20                  25                  30          


Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val 
        35                  40                  45              


Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val 
    50                  55                  60                  


Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys 
65                  70                  75                  80  


Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser 
                85                  90                  95      


Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu 
            100                 105                 110         


Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro 
        115                 120                 125             


Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys 
    130                 135                 140                 


Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met 
145                 150                 155                 160 


Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser 
                165                 170                 175     


Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser 
            180                 185                 190         


Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser 
        195                 200                 205             


Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser 
    210                 215                 220                 


Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln 
225                 230                 235                 240 


Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr 
                245                 250                 255     


Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg 
            260                 265                 270         


Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu 
        275                 280                 285             


Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly 
    290                 295                 300                 


His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe 
305                 310                 315                 320 


Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala 
                325                 330                 335     


Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His 
            340                 345                 350         


Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala 
        355                 360                 365             


Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val 
    370                 375                 380                 


His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe 
385                 390                 395                 400 


Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala 
                405                 410                 415     


Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu 
            420                 425                 430         


Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr 
        435                 440                 445             


Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly 
    450                 455                 460                 


Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu 
465                 470                 475                 480 


Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro 
                485                 490                 495     


Pro Leu Val Pro Ser Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser 
            500                 505                 510         


Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met 
        515                 520                 525             


Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His 
    530                 535                 540                 


Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His 
545                 550                 555                 560 


Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg 
                565                 570                 575     


Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val 
            580                 585                 590         


Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys 
        595                 600                 605             


Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala 
    610                 615                 620                 


Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg 
625                 630                 635                 640 


Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala 
                645                 650                 655     


Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val 
            660                 665                 670         


Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu 
        675                 680                 685             


Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu 
    690                 695                 700                 


Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Ile Ala Val Asp 
705                 710                 715                 720 


Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val 
                725                 730                 735     


Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr 
            740                 745                 750         


Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu 
        755                 760                 765             


Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu 
    770                 775                 780                 


Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu 
785                 790                 795                 800 


Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala 
                805                 810                 815     


Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe 
            820                 825                 830         


Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe 
        835                 840                 845             


Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu 
    850                 855                 860                 


Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg 
865                 870                 875                 880 


Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu 
                885                 890                 895     


His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr 
            900                 905                 910         


His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr 
        915                 920                 925             


Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp 
    930                 935                 940                 


Ala Leu Ser Asp Thr Glu Arg Gln Asp Phe His Gln Trp Ala Ile His 
945                 950                 955                 960 


Glu His Phe Leu Pro Glu Ser Ser Ala Ser Gly Gly Cys Asp Gly Asp 
                965                 970                 975     


Leu Gln Ala Ala Cys Thr Ile Leu Val Asn Ala Leu Met Asp Phe His 
            980                 985                 990         


Gln Ser Ser Arg Ser Tyr Asp His  Ser Glu Asn Ser Asp  Leu Val Phe 
        995                 1000                 1005             


Gly Gly  Arg Thr Gly Asn Glu  Asp Ile Ile Ser Arg  Leu Gln Glu 
    1010                 1015                 1020             


Met Val  Ala Asp Leu Glu Leu  Gln Gln Asp Leu Ile  Val Pro Leu 
    1025                 1030                 1035             


Gly His  Thr Pro Ser Gln Glu  His Phe Leu Phe Glu  Ile Phe Arg 
    1040                 1045                 1050             


Arg Arg  Leu Gln Ala Leu Thr  Ser Gly Trp Ser Val  Ala Ala Ser 
    1055                 1060                 1065             


Leu Gln  Arg Gln Arg Glu Leu  Leu Met Tyr Lys Arg  Ile Leu Leu 
    1070                 1075                 1080             


Arg Leu  Pro Ser Ser Val Leu  Cys Gly Ser Ser Phe  Gln Ala Glu 
    1085                 1090                 1095             


Gln Pro  Ile Thr Ala Arg Cys  Glu Gln Phe Phe His  Leu Val Asn 
    1100                 1105                 1110             


Ser Glu  Met Arg Asn Phe Cys  Ser His Gly Gly Ala  Leu Thr Gln 
    1115                 1120                 1125             


Asp Ile  Thr Ala His Phe Phe  Arg Gly Leu Leu Asn  Ala Cys Leu 
    1130                 1135                 1140             


Arg Ser  Arg Asp Pro Ser Leu  Met Val Asp Phe Ile  Leu Ala Lys 
    1145                 1150                 1155             


Cys Gln  Thr Lys Cys Pro Leu  Ile Leu Thr Ser Ala  Leu Val Trp 
    1160                 1165                 1170             


Trp Pro  Ser Leu Glu Pro Val  Leu Leu Cys Arg Trp  Arg Arg His 
    1175                 1180                 1185             


Cys Gln  Ser Pro Leu Pro Arg  Glu Leu Gln Lys Leu  Gln Glu Gly 
    1190                 1195                 1200             


Arg Gln  Phe Ala Ser Asp Phe  Leu Ser Pro Glu Ala  Ala Ser Pro 
    1205                 1210                 1215             


Ala Pro  Asn Pro Asp Trp Leu  Ser Ala Ala Ala Leu  His Phe Ala 
    1220                 1225                 1230             


Ile Gln  Gln Val Arg Glu Glu  Asn Ile Arg Lys Gln  Leu Lys Lys 
    1235                 1240                 1245             


Leu Asp  Cys Glu Arg Glu Glu  Leu Leu Val Phe Leu  Phe Phe Phe 
    1250                 1255                 1260             


Ser Leu  Met Gly Leu Leu Ser  Ser His Leu Thr Ser  Asn Ser Thr 
    1265                 1270                 1275             


Thr Asp  Leu Pro Lys Ala Phe  His Val Cys Ala Ala  Ile Leu Glu 
    1280                 1285                 1290             


Cys Leu  Glu Lys Arg Lys Ile  Ser Trp Leu Ala Leu  Phe Gln Leu 
    1295                 1300                 1305             


Thr Glu  Ser Asp Leu Arg Leu  Gly Arg Leu Leu Leu  Arg Val Ala 
    1310                 1315                 1320             


Pro Asp  Gln His Thr Arg Leu  Leu Pro Phe Ala Phe  Tyr Ser Leu 
    1325                 1330                 1335             


Leu Ser  Tyr Phe His Glu Asp  Ala Ala Ile Arg Glu  Glu Ala Phe 
    1340                 1345                 1350             


Leu His  Val Ala Val Asp Met  Tyr Leu Lys Leu Val  Gln Leu Phe 
    1355                 1360                 1365             


Val Ala  Gly Asp Thr Ser Thr  Val Ser Pro Pro Ala  Gly Arg Ser 
    1370                 1375                 1380             


Leu Glu  Leu Lys Gly Gln Gly  Asn Pro Val Glu Leu  Ile Thr Lys 
    1385                 1390                 1395             


Ala Arg  Leu Phe Leu Leu Gln  Leu Ile Pro Arg Cys  Pro Lys Lys 
    1400                 1405                 1410             


Ser Phe  Ser His Val Ala Glu  Leu Leu Ala Asp Arg  Gly Asp Cys 
    1415                 1420                 1425             


Asp Pro  Glu Val Ser Ala Ala  Leu Gln Ser Arg Gln  Gln Ala Ala 
    1430                 1435                 1440             


Pro Asp  Ala Asp Leu Ser Gln  Glu Pro His Leu Phe  
    1445                 1450                 1455 


<210>  37
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Gln Asp Ser Val Asp Leu Ser Cys Asp Tyr Gln Phe Trp Met 
1               5                   10                  15      


Gln Lys Leu Ser Val Trp Asp Gln Ala Ser Thr Leu Glu Thr Gln Gln 
            20                  25                  30          


Asp Thr Cys Leu His Val Ala Gln Phe Gln Glu Phe Leu Arg Lys Met 
        35                  40                  45              


Tyr Glu Ala Leu Lys Glu Met Asp Ser Asn Thr Val Ile Glu Arg Phe 
    50                  55                  60                  


Pro Thr Ile Gly Gln Leu Leu Ala Lys Ala Cys Trp Asn Pro Phe Ile 
65                  70                  75                  80  


Leu Ala Tyr Asp Glu Ser Gln Lys Ile Leu Ile Trp Cys Leu Cys Cys 
                85                  90                  95      


Leu Ile Asn Lys Glu Pro Gln Asn Ser Gly Gln Ser Lys Leu Asn Ser 
            100                 105                 110         


Trp Ile Gln Gly Val Leu Ser His Ile Leu Ser Ala Leu Arg Phe Asp 
        115                 120                 125             


Lys Glu Val Ala Leu Phe Thr Gln Gly Leu Gly Tyr Ala Pro Ile Asp 
    130                 135                 140                 


Tyr Tyr Pro Gly Leu Leu Lys Asn Met Val Leu Ser Leu Ala Ser Glu 
145                 150                 155                 160 


Leu Arg Glu Asn His Leu Asn Gly Phe Asn Thr Gln Arg Arg Met Ala 
                165                 170                 175     


Pro Glu Arg Val Ala Ser Leu Ser Arg Val Cys Val Pro Leu Ile Thr 
            180                 185                 190         


Leu Thr Asp Val Asp Pro Leu Val Glu Ala Leu Leu Ile Cys His Gly 
        195                 200                 205             


Arg Glu Pro Gln Glu Ile Leu Gln Pro Glu Phe Phe Glu Ala Val Asn 
    210                 215                 220                 


Glu Ala Ile Leu Leu Lys Lys Ile Ser Leu Pro Met Ser Ala Val Val 
225                 230                 235                 240 


Cys Leu Trp Leu Arg His Leu Pro Ser Leu Glu Lys Ala Met Leu His 
                245                 250                 255     


Leu Phe Glu Lys Leu Ile Ser Ser Glu Arg Asn Cys Leu Arg Arg Ile 
            260                 265                 270         


Glu Cys Phe Ile Lys Asp Ser Ser Leu Pro Gln Ala Ala Cys His Pro 
        275                 280                 285             


Ala Ile Phe Arg Val Val Asp Glu Met Phe Arg Cys Ala Leu Leu Glu 
    290                 295                 300                 


Thr Asp Gly Ala Leu Glu Ile Ile Ala Thr Ile Gln Val Phe Thr Gln 
305                 310                 315                 320 


Cys Phe Val Glu Ala Leu Glu Lys Ala Ser Lys Gln Leu Arg Phe Ala 
                325                 330                 335     


Leu Lys Thr Tyr Phe Pro Tyr Thr Ser Pro Ser Leu Ala Met Val Leu 
            340                 345                 350         


Leu Gln Asp Pro Gln Asp Ile Pro Arg Gly His Trp Leu Gln Thr Leu 
        355                 360                 365             


Lys His Ile Ser Glu Leu Leu Arg Glu Ala Val Glu Asp Gln Thr His 
    370                 375                 380                 


Gly Ser Cys Gly Gly Pro Phe Glu Ser Trp Phe Leu Phe Ile His Phe 
385                 390                 395                 400 


Gly Gly Trp Ala Glu Met Val Ala Glu Gln Leu Leu Met Ser Ala Ala 
                405                 410                 415     


Glu Pro Pro Thr Ala Leu Leu Trp Leu Leu Ala Phe Tyr Tyr Gly Pro 
            420                 425                 430         


Arg Asp Gly Arg Gln Gln Arg Ala Gln Thr Met Val Gln Val Lys Ala 
        435                 440                 445             


Val Leu Gly His Leu Leu Ala Met Ser Arg Ser Ser Ser Leu Ser Ala 
    450                 455                 460                 


Gln Asp Leu Gln Thr Val Ala Gly Gln Gly Thr Asp Thr Asp Leu Arg 
465                 470                 475                 480 


Ala Pro Ala Gln Gln Leu Ile Arg His Leu Leu Leu Asn Phe Leu Leu 
                485                 490                 495     


Trp Ala Pro Gly Gly His Thr Ile Ala Trp Asp Val Ile Thr Leu Met 
            500                 505                 510         


Ala His Thr Ala Glu Ile Thr His Glu Ile Ile Gly Phe Leu Asp Gln 
        515                 520                 525             


Thr Leu Tyr Arg Trp Asn Arg Leu Gly Ile Glu Ser Pro Arg Ser Glu 
    530                 535                 540                 


Lys Leu Ala Arg Glu Leu Leu Lys Glu Leu Arg Thr Gln Val 
545                 550                 555             


<210>  38
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro 
1               5                   10                  15      


Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala 
            20                  25                  30          


Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg 
        35                  40                  45              


Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu 
    50                  55                  60                  


Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg 
65                  70                  75                  80  


Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg 
                85                  90                  95      


Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser 
            100                 105                 110         


Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp 
        115                 120                 125             


Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu 
    130                 135                 140                 


Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys 
145                 150                 155                 160 


Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg 
                165                 170                 175     


Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg 
            180                 185                 190         


Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala 
        195                 200                 205             


Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu 
    210                 215                 220                 


Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val 
                245                 250                 255     


Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys 
            260                 265                 270         


Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu 
        275                 280                 285             


Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly 
    290                 295                 300                 


Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser 
305                 310                 315                 320 


Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu 
                325                 330                 335     


Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser 
            340                 345                 350         


Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe 
        355                 360                 365             


Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr 
    370                 375                 380                 


Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser 
385                 390                 395                 400 


Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln 
                405                 410                 415     


Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp 
            420                 425                 430         


Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu 
        435                 440                 445             


Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met 
    450                 455                 460                 


Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly 
465                 470                 475                 480 


Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val 
                485                 490                 495     


Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu 
            500                 505                 510         


Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys 
        515                 520                 525             


Ala Ala Leu Lys His Leu Gly Pro 
    530                 535     


<210>  39
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Glu Ser Leu Leu Gln His Leu Asp Arg Phe Ser Glu Leu Leu Ala 
1               5                   10                  15      


Val Ser Ser Thr Thr Tyr Val Ser Thr Trp Asp Pro Ala Thr Val Arg 
            20                  25                  30          


Arg Ala Leu Gln Trp Ala Arg Tyr Leu Arg His Ile His Arg Arg Phe 
        35                  40                  45              


Gly Arg His Gly Pro Ile Arg Thr Ala Leu Glu Arg Arg Leu His Asn 
    50                  55                  60                  


Gln Trp Arg Gln Glu Gly Gly Phe Gly Arg Gly Pro Val Pro Gly Leu 
65                  70                  75                  80  


Ala Asn Phe Gln Ala Leu Gly His Cys Asp Val Leu Leu Ser Leu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ala Leu Gly Asp Ala Ala Arg Tyr His Leu Val 
            100                 105                 110         


Gln Gln Leu Phe Pro Gly Pro Gly Val Arg Asp Ala Asp Glu Glu Thr 
        115                 120                 125             


Leu Gln Glu Ser Leu Ala Arg Leu Ala Arg Arg Arg Ser Ala Val His 
    130                 135                 140                 


Met Leu Arg Phe Asn Gly Tyr Arg Glu Asn Pro Asn Leu Gln Glu Asp 
145                 150                 155                 160 


Ser Leu Met Lys Thr Gln Ala Glu Leu Leu Leu Glu Arg Leu Gln Glu 
                165                 170                 175     


Val Gly Lys Ala Glu Ala Glu Arg Pro Ala Arg Phe Leu Ser Ser Leu 
            180                 185                 190         


Trp Glu Arg Leu Pro Gln Asn Asn Phe Leu Lys Val Ile Ala Val Ala 
        195                 200                 205             


Leu Leu Gln Pro Pro Leu Ser Arg Arg Pro Gln Glu Glu Leu Glu Pro 
    210                 215                 220                 


Gly Ile His Lys Ser Pro Gly Glu Gly Ser Gln Val Leu Val His Trp 
225                 230                 235                 240 


Leu Leu Gly Asn Ser Glu Val Phe Ala Ala Phe Cys Arg Ala Leu Pro 
                245                 250                 255     


Ala Gly Leu Leu Thr Leu Val Thr Ser Arg His Pro Ala Leu Ser Pro 
            260                 265                 270         


Val Tyr Leu Gly Leu Leu Thr Asp Trp Gly Gln Arg Leu His Tyr Asp 
        275                 280                 285             


Leu Gln Lys Gly Ile Trp Val Gly Thr Glu Ser Gln Asp Val Pro Trp 
    290                 295                 300                 


Glu Glu Leu His Asn Arg Phe Gln Ser Leu Cys Gln Ala Pro Pro Pro 
305                 310                 315                 320 


Leu Lys Asp Lys Val Leu Thr Ala Leu Glu Thr Cys Lys Ala Gln Asp 
                325                 330                 335     


Gly Asp Phe Glu Val Pro Gly Leu Ser Ile Trp Thr Asp Leu Leu Leu 
            340                 345                 350         


Ala Leu Arg Ser Gly Ala Phe Arg Lys Arg Gln Val Leu Gly Leu Ser 
        355                 360                 365             


Ala Gly Leu Ser Ser Val 
    370                 


<210>  40
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp 
1               5                   10                  15      


Arg Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn 
            20                  25                  30          


Ser Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu 
        35                  40                  45              


Gly Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val 
    50                  55                  60                  


Pro Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu 
65                  70                  75                  80  


Arg Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile 
                85                  90                  95      


Gln Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro 
            100                 105                 110         


Arg Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala 
        115                 120                 125             


Ser Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly 
    130                 135                 140                 


Leu Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala 
145                 150                 155                 160 


Leu Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp 
                165                 170                 175     


Leu Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp 
            180                 185                 190         


Ala Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu 
        195                 200                 205             


Thr Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn 
    210                 215                 220                 


Pro Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys 
225                 230                 235                 240 


Pro Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His 
                245                 250                 255     


Arg Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala 
            260                 265                 270         


Leu Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg 
        275                 280                 285             


Leu Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu 
    290                 295                 300                 


Leu Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln 
305                 310                 315                 320 


Phe Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser 
                325                 330                 335     


Pro Leu His Cys Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser 
            340                 345                 350         


Arg Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu 
        355                 360                 365             


Asp Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro Arg Phe Ser Pro 
    370                 375                 380                 


Pro Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val Phe Leu Glu Ala 
385                 390                 395                 400 


Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr Leu 
                405                 410                 415     


Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met Ser 
            420                 425                 430         


Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr Cys 
        435                 440                 445             


Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp Val 
    450                 455                 460                 


Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys Leu 
465                 470                 475                 480 


Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala Ala 
                485                 490                 495     


Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln Leu 
            500                 505                 510         


Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp Val Ala Ser Gly 
        515                 520                 525             


Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser Val Gln Met Cys 
    530                 535                 540                 


Pro Gly Asn Arg Asp Thr Tyr Phe His Leu Leu Gln Thr Leu Lys Arg 
545                 550                 555                 560 


Leu Asp Arg Arg Asp Glu Ala Thr Ala Leu Trp Trp Arg Leu Glu Ala 
                565                 570                 575     


Gln Thr Lys Gly Ser His Glu Asp Ala Leu Trp Ser Leu Pro Leu Tyr 
            580                 585                 590         


Leu Glu Ser Tyr Leu Ser Trp Ile Arg Pro Ser Asp Arg Asp Ala Phe 
        595                 600                 605             


Leu Glu Glu Phe Arg Thr Ser Leu Pro Lys Ser Cys Asp Leu 
    610                 615                 620         


<210>  41
<211>  1110
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon optimized human gammaC DNA

<400>  41
atgctgaaac caagcctgcc ctttacaagc ctgctgttcc tgcagctgcc actgctgggg       60

gtcggactga atactacaat cctgacacca aacggaaatg aggacaccac agccgatttc      120

tttctgacta ccatgcccac tgacagtctg tcagtgagca ccctgccact gcccgaggtc      180

cagtgcttcg tgtttaacgt cgaatatatg aactgtacct ggaatagctc ctctgaacct      240

cagccaacaa atctgactct gcactactgg tataagaact ctgacaatga taaggtgcag      300

aaatgctcac attatctgtt cagcgaggaa atcacctccg gctgtcagct gcagaagaaa      360

gagattcacc tgtaccagac atttgtggtc cagctgcagg atccccggga acctcggaga      420

caggccactc agatgctgaa gctgcagaac ctggtcatcc catgggctcc cgagaatctg      480

accctgcata aactgtccga gtctcagctg gaactgaact ggaacaatag gttcctgaat      540

cactgcctgg agcatctggt gcagtaccgc acagactggg atcactcttg gactgaacag      600

agtgtggact atcgacataa gtttagtctg ccttcagtgg atgggcagaa aaggtacaca      660

ttcagggtcc gctctcggtt caacccactg tgcggaagcg cccagcactg gagcgagtgg      720

tcccacccca tccattgggg gtctaacacc agcaaggaga atcctttcct gtttgccctg      780

gaagctgtgg tcatttcagt gggaagcatg ggcctgatca ttagcctgct gtgcgtgtac      840

ttctggctgg agcggaccat gcctagaatc ccaacactga agaacctgga ggacctggtg      900

acagaatatc acggcaattt ttccgcttgg tctggggtca gtaaaggact ggcagagagc      960

ctgcagcccg attactccga gcggctgtgc ctggtgtccg aaattccccc taaaggcggg     1020

gcactgggag aaggccctgg ggcctccccc tgcaaccagc actcacccta ttgggcacca     1080

ccctgttaca ccctgaaacc cgaaacttaa                                      1110


<210>  42
<211>  1110
<212>  DNA
<213>  Homo sapiens

<400>  42
atgttgaagc catcattacc attcacatcc ctcttattcc tgcagctgcc cctgctggga       60

gtggggctga acacgacaat tctgacgccc aatgggaatg aagacaccac agctgatttc      120

ttcctgacca ctatgcccac tgactccctc agcgtttcca ctctgcccct cccagaggtt      180

cagtgttttg tgttcaatgt cgagtacatg aattgcactt ggaacagcag ctctgagccc      240

cagcctacca acctcactct gcattattgg tacaagaact cggataatga taaagtccag      300

aagtgcagcc actatctatt ctctgaagaa atcacttctg gctgtcagtt gcaaaaaaag      360

gagatccacc tctaccaaac atttgttgtt cagctccagg acccacggga acccaggaga      420

caggccacac agatgctaaa actgcagaat ctggtgatcc cctgggctcc agagaaccta      480

acacttcaca aactgagtga atcccagcta gaactgaact ggaacaacag attcttgaac      540

cactgtttgg agcacttggt gcagtaccgg actgactggg accacagctg gactgaacaa      600

tcagtggatt atagacataa gttctccttg cctagtgtgg atgggcagaa acgctacacg      660

tttcgtgttc ggagccgctt taacccactc tgtggaagtg ctcagcattg gagtgaatgg      720

agccacccaa tccactgggg gagcaatact tcaaaagaga atcctttcct gtttgcattg      780

gaagccgtgg ttatctctgt tggctccatg ggattgatta tcagccttct ctgtgtgtat      840

ttctggctgg aacggacgat gccccgaatt cccaccctga agaacctaga ggatcttgtt      900

actgaatacc acgggaactt ttcggcctgg agtggtgtgt ctaagggact ggctgagagt      960

ctgcagccag actacagtga acgactctgc ctcgtcagtg agattccccc aaaaggaggg     1020

gcccttgggg aggggcctgg ggcctcccca tgcaaccagc atagccccta ctgggccccc     1080

ccatgttaca ccctaaagcc tgaaacctga                                      1110


<210>  43
<211>  1114
<212>  DNA
<213>  Canis lupus familiaris

<400>  43
atgttgaagc caccattgcc actcagatcc ctcttattcc tgcagctgtc tctgctgggg       60

gtggggctga actccacggt ccccatgccc aatgggaatg aagacatcac acctgatttc      120

ttcctgaccg ctacaccctc cgagaccctc agtgtttcct ccctgcccct cccagaggtc      180

cagtgttttg tgttcaatgt tgagtacatg aattgcactt ggaacagcag ctctgagccc      240

cggcccacca acctgaccct gcactactgg tataagaact ccaatgatga taaagtccag      300

gagtgtggcc actacctatt ctctagagag gtcactgctg gctgttggtt gcagaaggag      360

gagatccatc tctacgaaac atttgttgtc cagctccggg acccacggga acccaggagg      420

cagtccacac agaagctaaa actgcaaaat ctggtgatcc cctgggctcc ggagaaccta      480

acccttcaca acctgagcga atcccagcta gaactgagct ggagcaacag acacttggac      540

cactgtttgg agcatgttgt gcagtaccgg agtgactggg accgcagctg gactgaacag      600

tcagtggacc accgaaatag cttctctctg cctagcgtgg atgggcagaa gttctacacg      660

ttccgtgtcc gaagccgcta taacccactc tgtggaagcg ctcagcgttg gagtgaatgg      720

agccacccta tccactgggg gagcaatacc tccaaggaga atcctttgtt tgcatcggaa      780

gctgtgctta tcccccttgg ctccatggga ttgattatta gccttatctg tgtgtactac      840

tggctggaac ggtcgatccc ccgaattcct accctcaaga acctggagga tctggttact      900

gaatatcacg ggaatttttc ggcctggagt ggagtgtcta agggactggc ggagagtctg      960

cagccagact acagtgaatg gctctgccac gtcagtgaga ttcccccaaa aggaggggct     1020

ccaggggagg gtcctggggg ctccccctgc agccagcata gcccctactg ggctccccca     1080

tgttataccc tgaaacctga aactggagcc ctga                                 1114


<210>  44
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  45
<211>  373
<212>  PRT
<213>  Canis lupus familiaris

<400>  45

Met Leu Lys Pro Pro Leu Pro Leu Arg Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Ser Leu Leu Gly Val Gly Leu Asn Ser Thr Val Pro Met Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Ile Thr Pro Asp Phe Phe Leu Thr Ala Thr Pro Ser Glu 
        35                  40                  45              


Thr Leu Ser Val Ser Ser Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Arg Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asn Asp 
                85                  90                  95      


Asp Lys Val Gln Glu Cys Gly His Tyr Leu Phe Ser Arg Glu Val Thr 
            100                 105                 110         


Ala Gly Cys Trp Leu Gln Lys Glu Glu Ile His Leu Tyr Glu Thr Phe 
        115                 120                 125             


Val Val Gln Leu Arg Asp Pro Arg Glu Pro Arg Arg Gln Ser Thr Gln 
    130                 135                 140                 


Lys Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Asn Leu Ser Glu Ser Gln Leu Glu Leu Ser Trp Ser Asn 
                165                 170                 175     


Arg His Leu Asp His Cys Leu Glu His Val Val Gln Tyr Arg Ser Asp 
            180                 185                 190         


Trp Asp Arg Ser Trp Thr Glu Gln Ser Val Asp His Arg Asn Ser Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Phe Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Tyr Asn Pro Leu Cys Gly Ser Ala Gln Arg Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Leu 
                245                 250                 255     


Phe Ala Ser Glu Ala Val Leu Ile Pro Leu Gly Ser Met Gly Leu Ile 
            260                 265                 270         


Ile Ser Leu Ile Cys Val Tyr Tyr Trp Leu Glu Arg Ser Ile Pro Arg 
        275                 280                 285             


Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly 
    290                 295                 300                 


Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu 
305                 310                 315                 320 


Gln Pro Asp Tyr Ser Glu Trp Leu Cys His Val Ser Glu Ile Pro Pro 
                325                 330                 335     


Lys Gly Gly Ala Pro Gly Glu Gly Pro Gly Gly Ser Pro Cys Ser Gln 
            340                 345                 350         


His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
        355                 360                 365             


Gly Ala Leu Ile Pro 
    370             


<210>  46
<211>  3375
<212>  DNA
<213>  Homo sapiens

<400>  46
atggcacctc caagtgaaga gacgcccctg atccctcagc gttcatgcag cctcttgtcc       60

acggaggctg gtgccctgca tgtgctgctg cccgctcggg gccccgggcc cccccagcgc      120

ctatctttct cctttgggga ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc      180

agcggcatcc tgcctgtgta ccactccctc tttgctctgg ccacggagga cctgtcctgc      240

tggttccccc cgagccacat cttctccgtg gaggatgcca gcacccaagt cctgctgtac      300

aggattcgct tttacttccc caattggttt gggctggaga agtgccaccg cttcgggcta      360

cgcaaggatt tggccagtgc tatccttgac ctgccagtcc tggagcacct ctttgcccag      420

caccgcagtg acctggtgag tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt      480

gagtgtctca gcctggccgt gttggacctg gcccggatgg cgcgagagca ggcccagcgg      540

ccgggagagc tgctgaagac tgtcagctac aaggcctgcc tacccccaag cctgcgcgac      600

ctgatccagg gcctgagctt cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc      660

ctgcgccgcg tggccgcctg ccaggcagac cggcactcgc tcatggccaa gtacatcatg      720

gacctggagc ggctggatcc agccggggcc gccgagacct tccacgtggg cctccctggg      780

gcccttggtg gccacgacgg gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc      840

tggacccagg gagaacagga ggtcctccag cccttctgcg actttccaga aatcgtagac      900

attagcatca agcaggcccc gcgcgttggc ccggccggag agcaccgcct ggtcactgtt      960

accaggacag acaaccagat tttagaggcc gagttcccag ggctgcccga ggctctgtcg     1020

ttcgtggcgc tcgtggacgg ctacttccgg ctgaccacgg actcccagca cttcttctgc     1080

aaggaggtgg caccgccgag gctgctggag gaagtggccg agcagtgcca cggccccatc     1140

actctggact ttgccatcaa caagctcaag actgggggct cacgtcctgg ctcctatgtt     1200

ctccgccgca gcccccagga ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc     1260

cttggtcctg attataaggg ctgcctcatc cggcgcagcc ccacaggaac cttccttctg     1320

gttggcctca gccgacccca cagcagtctt cgagagctcc tggcaacctg ctgggatggg     1380

gggctgcacg tagatggggt ggcagtgacc ctcacttcct gctgtatccc cagacccaaa     1440

gaaaagtcca acctgatcgt ggtccagaga ggtcacagcc cacccacatc atccttggtt     1500

cagccccaat cccaatacca gctgagtcag atgacatttc acaagatccc tgctgacagc     1560

ctggagtggc atgagaacct gggccatggg tccttcacca agatttaccg gggctgtcgc     1620

catgaggtgg tggatgggga ggcccgaaag acagaggtgc tgctgaaggt catggatgcc     1680

aagcacaaga actgcatgga gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg     1740

taccggcatc tcgtgctgct ccacggcgtg tgcatggctg gagacagcac catggtgcag     1800

gaatttgtac acctgggggc catagacatg tatctgcgaa aacgtggcca cctggtgcca     1860

gccagctgga agctgcaggt ggtcaaacag ctggcctacg ccctcaacta tctggaggac     1920

aaaggcctgc cccatggcaa tgtctctgcc cggaaggtgc tcctggctcg ggagggggct     1980

gatgggagcc cgcccttcat caagctgagt gaccctgggg tcagccccgc tgtgttaagc     2040

ctggagatgc tcaccgacag gatcccctgg gtggcccccg agtgtctccg ggaggcgcag     2100

acacttagct tggaagctga caagtggggc ttcggcgcca cggtctggga agtgtttagt     2160

ggcgtcacca tgcccatcag tgccctggat cctgctaaga aactccaatt ttatgaggac     2220

cggcagcagc tgccggcccc caagtggaca gagctggccc tgctgattca acagtgcatg     2280

gcctatgagc cggtccagag gccctccttc cgagccgtca ttcgtgacct caatagcctc     2340

atctcttcag actatgagct cctctcagac cccacacctg gtgccctggc acctcgtgat     2400

gggctgtgga atggtgccca gctctatgcc tgccaagacc ccacgatctt cgaggagaga     2460

cacctcaagt acatctcaca gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc     2520

tatgacccgc taggcgacaa tacaggtgcc ctggtggccg tgaaacagct gcagcacagc     2580

gggccagacc agcagaggga ctttcagcgg gagattcaga tcctcaaagc actgcacagt     2640

gatttcattg tcaagtatcg tggtgtcagc tatggcccgg gccgccagag cctgcggctg     2700

gtcatggagt acctgcccag cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc     2760

ctcgatgcca gccgcctcct tctctattcc tcgcagatct gcaagggcat ggagtacctg     2820

ggctcccgcc gctgcgtgca ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag     2880

gcacacgtca agatcgctga cttcggccta gctaagctgc tgccgcttga caaagactac     2940

tacgtggtcc gcgagccagg ccagagcccc attttctggt atgcccccga atccctctcg     3000

gacaacatct tctctcgcca gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc     3060

ttcacctact gcgacaaaag ctgcagcccc tcggccgagt tcctgcggat gatgggatgt     3120

gagcgggatg tccccgccct ctgccgcctc ttggaactgc tggaggaggg ccagaggctg     3180

ccggcgcctc ctgcctgccc tgctgaggtt cacgagctca tgaagctgtg ctgggcccct     3240

agcccacagg accggccatc attcagcgcc ctgggccccc agctggacat gctgtggagc     3300

ggaagccggg ggtgtgagac tcatgccttc actgctcacc cagagggcaa acaccactcc     3360

ctgtcctttt catag                                                      3375


<210>  47
<211>  870
<212>  DNA
<213>  Homo sapiens

<400>  47
atggagaacg gatacaccta tgaagattat aagaacactg cagaatggct tctgtctcac       60

actaagcacc gacctcaagt tgcaataatc tgtggttctg gattaggagg tctgactgat      120

aaattaactc aggcccagat ctttgactac ggtgaaatcc ccaactttcc ccgaagtaca      180

gtgccaggtc atgctggccg actggtgttt gggttcctga atggcagggc ctgtgtgatg      240

atgcagggca ggttccacat gtatgaaggg tacccactct ggaaggtgac attcccagtg      300

agggttttcc accttctggg tgtggacacc ctggtagtca ccaatgcagc aggagggctg      360

aaccccaagt ttgaggttgg agatatcatg ctgatccgtg accatatcaa cctacctggt      420

ttcagtggtc agaaccctct cagagggccc aatgatgaaa ggtttggaga tcgtttccct      480

gccatgtctg atgcctacga ccggactatg aggcagaggg ctctcagtac ctggaaacaa      540

atgggggagc aacgtgagct acaggaaggc acctatgtga tggtggcagg ccccagcttt      600

gagactgtgg cagaatgtcg tgtgctgcag aagctgggag cagacgctgt tggcatgagt      660

acagtaccag aagttatcgt tgcacggcac tgtggacttc gagtctttgg cttctcactc      720

atcactaaca aggtcatcat ggattatgaa agcctggaga aggccaacca tgaagaagtc      780

ttagcagctg gcaaacaagc tgcacagaaa ttggaacagt ttgtctccat tcttatggcc      840

agcattccac tccctgacaa agccagttga                                       870


<210>  48
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  48
atggcccaga cgcccgcctt cgacaagccc aaagtagaac tgcatgtcca cctagacgga       60

tccatcaagc ctgaaaccat cttatactat ggcaggagga gagggatcgc cctcccagct      120

aacacagcag aggggctgct gaacgtcatt ggcatggaca agccgctcac ccttccagac      180

ttcctggcca agtttgacta ctacatgcct gctatcgcgg gctgccggga ggctatcaaa      240

aggatcgcct atgagtttgt agagatgaag gccaaagagg gcgtggtgta tgtggaggtg      300

cggtacagtc cgcacctgct ggccaactcc aaagtggagc caatcccctg gaaccaggct      360

gaaggggacc tcaccccaga cgaggtggtg gccctagtgg gccagggcct gcaggagggg      420

gagcgagact tcggggtcaa ggcccggtcc atcctgtgct gcatgcgcca ccagcccaac      480

tggtccccca aggtggtgga gctgtgtaag aagtaccagc agcagaccgt ggtagccatt      540

gacctggctg gagatgagac catcccagga agcagcctct tgcctggaca tgtccaggcc      600

taccaggagg ctgtgaagag cggcattcac cgtactgtcc acgccgggga ggtgggctcg      660

gccgaagtag taaaagaggc tgtggacata ctcaagacag agcggctggg acacggctac      720

cacaccctgg aagaccaggc cctttataac aggctgcggc aggaaaacat gcacttcgag      780

atctgcccct ggtccagcta cctcactggt gcctggaagc cggacacgga gcatgcagtc      840

attcggctca aaaatgacca ggctaactac tcgctcaaca cagatgaccc gctcatcttc      900

aagtccaccc tggacactga ttaccagatg accaaacggg acatgggctt tactgaagag      960

gagtttaaaa ggctgaacat caatgcggcc aaatctagtt tcctcccaga agatgaaaag     1020

agggagcttc tcgacctgct ctataaagcc tatgggatgc caccttcagc ctctgcaggg     1080

cagaacctct ga                                                         1092


<210>  49
<211>  3132
<212>  DNA
<213>  Homo sapiens

<400>  49
atggcagcct ctttcccacc caccttggga ctcagttctg ccccagatga aattcagcac       60

ccacatatta aattttcaga atggaaattt aagctgttcc gggtgagatc ctttgaaaag      120

acacctgaag aagctcaaaa ggaaaagaag gattcctttg aggggaaacc ctctctggag      180

caatctccag cagtcctgga caaggctgat ggtcagaagc cagtcccaac tcagccattg      240

ttaaaagccc accctaagtt ttcaaagaaa tttcacgaca acgagaaagc aagaggcaaa      300

gcgatccatc aagccaacct tcgacatctc tgccgcatct gtgggaattc ttttagagct      360

gatgagcaca acaggagata tccagtccat ggtcctgtgg atggtaaaac cctaggcctt      420

ttacgaaaga aggaaaagag agctacttcc tggccggacc tcattgccaa ggttttccgg      480

atcgatgtga aggcagatgt tgactcgatc caccccactg agttctgcca taactgctgg      540

agcatcatgc acaggaagtt tagcagtgcc ccatgtgagg tttacttccc gaggaacgtg      600

accatggagt ggcaccccca cacaccatcc tgtgacatct gcaacactgc ccgtcgggga      660

ctcaagagga agagtcttca gccaaacttg cagctcagca aaaaactcaa aactgtgctt      720

gaccaagcaa gacaagcccg tcagcgcaag agaagagctc aggcaaggat cagcagcaag      780

gatgtcatga agaagatcgc caactgcagt aagatacatc ttagtaccaa gctccttgca      840

gtggacttcc cagagcactt tgtgaaatcc atctcctgcc agatctgtga acacattctg      900

gctgaccctg tggagaccaa ctgtaagcat gtcttttgcc gggtctgcat tctcagatgc      960

ctcaaagtca tgggcagcta ttgtccctct tgccgatatc catgcttccc tactgacctg     1020

gagagtccag tgaagtcctt tctgagcgtc ttgaattccc tgatggtgaa atgtccagca     1080

aaagagtgca atgaggaggt cagtttggaa aaatataatc accacatctc aagtcacaag     1140

gaatcaaaag agatttttgt gcacattaat aaagggggcc ggccccgcca acatcttctg     1200

tcgctgactc ggagagctca gaagcaccgg ctgagggagc tcaagctgca agtcaaagcc     1260

tttgctgaca aagaagaagg tggagatgtg aagtccgtgt gcatgacctt gttcctgctg     1320

gctctgaggg cgaggaatga gcacaggcaa gctgatgagc tggaggccat catgcaggga     1380

aagggctctg gcctgcagcc agctgtttgc ttggccatcc gtgtcaacac cttcctcagc     1440

tgcagtcagt accacaagat gtacaggact gtgaaagcca tcacagggag acagattttt     1500

cagcctttgc atgcccttcg gaatgctgag aaggtacttc tgccaggcta ccaccacttt     1560

gagtggcagc cacctctgaa gaatgtgtct tccagcactg atgttggcat tattgatggg     1620

ctgtctggac tatcatcctc tgtggatgat tacccagtgg acaccattgc aaagaggttc     1680

cgctatgatt cagctttggt gtctgctttg atggacatgg aagaagacat cttggaaggc     1740

atgagatccc aagaccttga tgattacctg aatggcccct tcactgtggt ggtgaaggag     1800

tcttgtgatg gaatgggaga cgtgagtgag aagcatggga gtgggcctgt agttccagaa     1860

aaggcagtcc gtttttcatt cacaatcatg aaaattacta ttgcccacag ctctcagaat     1920

gtgaaagtat ttgaagaagc caaacctaac tctgaactgt gttgcaagcc attgtgcctt     1980

atgctggcag atgagtctga ccacgagacg ctgactgcca tcctgagtcc tctcattgct     2040

gagagggagg ccatgaagag cagtgaatta atgcttgagc tgggaggcat tctccggact     2100

ttcaagttca tcttcagggg caccggctat gatgaaaaac ttgtgcggga agtggaaggc     2160

ctcgaggctt ctggctcagt ctacatttgt actctttgtg atgccacccg tctggaagcc     2220

tctcaaaatc ttgtcttcca ctctataacc agaagccatg ctgagaacct ggaacgttat     2280

gaggtctggc gttccaaccc ttaccatgag tctgtggaag aactgcggga tcgggtgaaa     2340

ggggtctcag ctaaaccttt cattgagaca gtcccttcca tagatgcact ccactgtgac     2400

attggcaatg cagctgagtt ctacaagatc ttccagctag agatagggga agtgtataag     2460

aatcccaatg cttccaaaga ggaaaggaaa aggtggcagg ccacactgga caagcatctc     2520

cggaagaaga tgaacctcaa accaatcatg aggatgaatg gcaactttgc caggaagctc     2580

atgaccaaag agactgtgga tgcagtttgt gagttaattc cttccgagga gaggcacgag     2640

gctctgaggg agctgatgga tctttacctg aagatgaaac cagtatggcg atcatcatgc     2700

cctgctaaag agtgcccaga atccctctgc cagtacagtt tcaattcaca gcgttttgct     2760

gagctccttt ctacgaagtt caagtatagg tatgagggaa aaatcaccaa ttattttcac     2820

aaaaccctgg cccatgttcc tgaaattatt gagagggatg gctccattgg ggcatgggca     2880

agtgagggaa atgagtctgg taacaaactg tttaggcgct tccggaaaat gaatgccagg     2940

cagtccaaat gctatgagat ggaagatgtc ctgaaacacc actggttgta cacctccaaa     3000

tacctccaga agtttatgaa tgctcataat gcattaaaaa cctctgggtt taccatgaac     3060

cctcaggcaa gcttagggga cccattaggc atagaggact ctctggaaag ccaagattca     3120

atggaatttt aa                                                         3132


<210>  50
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  50
atgtctctgc agatggtaac agtcagtaat aacatagcct taattcagcc aggcttctca       60

ctgatgaatt ttgatggaca agttttcttc tttggacaaa aaggctggcc caaaagatcc      120

tgccccactg gagttttcca tctggatgta aagcataacc atgtcaaact gaagcctaca      180

attttctcta aggattcctg ctacctccct cctcttcgct acccagccac ttgcacattc      240

aaaggcagct tggagtctga aaagcatcaa tacatcatcc atggagggaa aacaccaaac      300

aatgaggttt cagataagat ttatgtcatg tctattgttt gcaagaacaa caaaaaggtt      360

acttttcgct gcacagagaa agacttggta ggagatgttc ctgaagccag atatggtcat      420

tccattaatg tggtgtacag ccgagggaaa agtatgggtg ttctctttgg aggacgctca      480

tacatgcctt ctacccacag aaccacagaa aaatggaata gtgtagctga ctgcctgccc      540

tgtgttttcc tggtggattt tgaatttggg tgtgctacat catacattct tccagaactt      600

caggatgggc tatcttttca tgtctctatt gccaaaaatg acaccatcta tattttagga      660

ggacattcac ttgccaataa tatccggcct gccaacctgt acagaataag ggttgatctt      720

cccctgggta gcccagctgt gaattgcaca gtcttgccag gaggaatctc tgtctccagt      780

gcaatcctga ctcaaactaa caatgatgaa tttgttattg ttggtggcta tcagcttgaa      840

aatcaaaaaa gaatgatctg caacatcatc tctttagagg acaacaagat agaaattcgt      900

gagatggaga ccccagattg gaccccagac attaagcaca gcaagatatg gtttggaagc      960

aacatgggaa atggaactgt ttttcttggc ataccaggag acaataaaca agttgtttca     1020

gaaggattct atttctatat gttgaaatgt gctgaagatg atactaatga agagcagaca     1080

acattcacaa acagtcaaac atcaacagaa gatccagggg attccactcc ctttgaagac     1140

tctgaagaat tttgtttcag tgcagaagca aatagttttg atggtgatga tgaatttgac     1200

acctataatg aagatgatga agaagatgag tctgagacag gctactggat tacatgctgc     1260

cctacttgtg atgtggatat caacacttgg gtaccattct attcaactga gctcaacaaa     1320

cccgccatga tctactgctc tcatggggat gggcactggg tccatgctca gtgcatggat     1380

ctggcagaac gcacactcat ccatctgtca gcaggaagca acaagtatta ctgcaatgag     1440

catgtggaga tagcaagagc tctacacact ccccaaagag tcctaccctt aaaaaagcct     1500

ccaatgaaat ccctccgtaa aaaaggttct ggaaaaatct tgactcctgc caagaaatcc     1560

tttcttagaa ggttgtttga ttag                                            1584


<210>  51
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln 
                885                 890                 895     


Ser Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  52
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210>  53
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Gln Thr Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Thr Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Thr Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Thr Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Thr Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Thr 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Thr Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Glu Ala Val Lys Ser Gly 
        195                 200                 205             


Ile His Arg Thr Val His Ala Gly Glu Val Gly Ser Ala Glu Val Val 
    210                 215                 220                 


Lys Glu Ala Val Asp Ile Leu Lys Thr Glu Arg Leu Gly His Gly Tyr 
225                 230                 235                 240 


His Thr Leu Glu Asp Gln Ala Leu Tyr Asn Arg Leu Arg Gln Glu Asn 
                245                 250                 255     


Met His Phe Glu Ile Cys Pro Trp Ser Ser Tyr Leu Thr Gly Ala Trp 
            260                 265                 270         


Lys Pro Asp Thr Glu His Ala Val Ile Arg Leu Lys Asn Asp Gln Ala 
        275                 280                 285             


Asn Tyr Ser Leu Asn Thr Asp Asp Pro Leu Ile Phe Lys Ser Thr Leu 
    290                 295                 300                 


Asp Thr Asp Tyr Gln Met Thr Lys Arg Asp Met Gly Phe Thr Glu Glu 
305                 310                 315                 320 


Glu Phe Lys Arg Leu Asn Ile Asn Ala Ala Lys Ser Ser Phe Leu Pro 
                325                 330                 335     


Glu Asp Glu Lys Arg Glu Leu Leu Asp Leu Leu Tyr Lys Ala Tyr Gly 
            340                 345                 350         


Met Pro Pro Ser Ala Ser Ala Gly Gln Asn Leu 
        355                 360             


<210>  54
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Ala Ser Phe Pro Pro Thr Leu Gly Leu Ser Ser Ala Pro Asp 
1               5                   10                  15      


Glu Ile Gln His Pro His Ile Lys Phe Ser Glu Trp Lys Phe Lys Leu 
            20                  25                  30          


Phe Arg Val Arg Ser Phe Glu Lys Thr Pro Glu Glu Ala Gln Lys Glu 
        35                  40                  45              


Lys Lys Asp Ser Phe Glu Gly Lys Pro Ser Leu Glu Gln Ser Pro Ala 
    50                  55                  60                  


Val Leu Asp Lys Ala Asp Gly Gln Lys Pro Val Pro Thr Gln Pro Leu 
65                  70                  75                  80  


Leu Lys Ala His Pro Lys Phe Ser Lys Lys Phe His Asp Asn Glu Lys 
                85                  90                  95      


Ala Arg Gly Lys Ala Ile His Gln Ala Asn Leu Arg His Leu Cys Arg 
            100                 105                 110         


Ile Cys Gly Asn Ser Phe Arg Ala Asp Glu His Asn Arg Arg Tyr Pro 
        115                 120                 125             


Val His Gly Pro Val Asp Gly Lys Thr Leu Gly Leu Leu Arg Lys Lys 
    130                 135                 140                 


Glu Lys Arg Ala Thr Ser Trp Pro Asp Leu Ile Ala Lys Val Phe Arg 
145                 150                 155                 160 


Ile Asp Val Lys Ala Asp Val Asp Ser Ile His Pro Thr Glu Phe Cys 
                165                 170                 175     


His Asn Cys Trp Ser Ile Met His Arg Lys Phe Ser Ser Ala Pro Cys 
            180                 185                 190         


Glu Val Tyr Phe Pro Arg Asn Val Thr Met Glu Trp His Pro His Thr 
        195                 200                 205             


Pro Ser Cys Asp Ile Cys Asn Thr Ala Arg Arg Gly Leu Lys Arg Lys 
    210                 215                 220                 


Ser Leu Gln Pro Asn Leu Gln Leu Ser Lys Lys Leu Lys Thr Val Leu 
225                 230                 235                 240 


Asp Gln Ala Arg Gln Ala Arg Gln His Lys Arg Arg Ala Gln Ala Arg 
                245                 250                 255     


Ile Ser Ser Lys Asp Val Met Lys Lys Ile Ala Asn Cys Ser Lys Ile 
            260                 265                 270         


His Leu Ser Thr Lys Leu Leu Ala Val Asp Phe Pro Glu His Phe Val 
        275                 280                 285             


Lys Ser Ile Ser Cys Gln Ile Cys Glu His Ile Leu Ala Asp Pro Val 
    290                 295                 300                 


Glu Thr Asn Cys Lys His Val Phe Cys Arg Val Cys Ile Leu Arg Cys 
305                 310                 315                 320 


Leu Lys Val Met Gly Ser Tyr Cys Pro Ser Cys Arg Tyr Pro Cys Phe 
                325                 330                 335     


Pro Thr Asp Leu Glu Ser Pro Val Lys Ser Phe Leu Ser Val Leu Asn 
            340                 345                 350         


Ser Leu Met Val Lys Cys Pro Ala Lys Glu Cys Asn Glu Glu Val Ser 
        355                 360                 365             


Leu Glu Lys Tyr Asn His His Ile Ser Ser His Lys Glu Ser Lys Glu 
    370                 375                 380                 


Ile Phe Val His Ile Asn Lys Gly Gly Arg Pro Arg Gln His Leu Leu 
385                 390                 395                 400 


Ser Leu Thr Arg Arg Ala Gln Lys His Arg Leu Arg Glu Leu Lys Leu 
                405                 410                 415     


Gln Val Lys Ala Phe Ala Asp Lys Glu Glu Gly Gly Asp Val Lys Ser 
            420                 425                 430         


Val Cys Met Thr Leu Phe Leu Leu Ala Leu Arg Ala Arg Asn Glu His 
        435                 440                 445             


Arg Gln Ala Asp Glu Leu Glu Ala Ile Met Gln Gly Lys Gly Ser Gly 
    450                 455                 460                 


Leu Gln Pro Ala Val Cys Leu Ala Ile Arg Val Asn Thr Phe Leu Ser 
465                 470                 475                 480 


Cys Ser Gln Tyr His Lys Met Tyr Arg Thr Val Lys Ala Ile Thr Gly 
                485                 490                 495     


Arg Gln Ile Phe Gln Pro Leu His Ala Leu Arg Asn Ala Glu Lys Val 
            500                 505                 510         


Leu Leu Pro Gly Tyr His His Phe Glu Trp Gln Pro Pro Leu Lys Asn 
        515                 520                 525             


Val Ser Ser Ser Thr Asp Val Gly Ile Ile Asp Gly Leu Ser Gly Leu 
    530                 535                 540                 


Ser Ser Ser Val Asp Asp Tyr Pro Val Asp Thr Ile Ala Lys Arg Phe 
545                 550                 555                 560 


Arg Tyr Asp Ser Ala Leu Val Ser Ala Leu Met Asp Met Glu Glu Asp 
                565                 570                 575     


Ile Leu Glu Gly Met Arg Ser Gln Asp Leu Asp Asp Tyr Leu Asn Gly 
            580                 585                 590         


Pro Phe Thr Val Val Val Lys Glu Ser Cys Asp Gly Met Gly Asp Val 
        595                 600                 605             


Ser Glu Lys His Gly Ser Gly Pro Val Val Pro Glu Lys Ala Val Arg 
    610                 615                 620                 


Phe Ser Phe Thr Ile Met Lys Ile Thr Ile Ala His Ser Ser Gln Asn 
625                 630                 635                 640 


Val Lys Val Phe Glu Glu Ala Lys Pro Asn Ser Glu Leu Cys Cys Lys 
                645                 650                 655     


Pro Leu Cys Leu Met Leu Ala Asp Glu Ser Asp His Glu Thr Leu Thr 
            660                 665                 670         


Ala Ile Leu Ser Pro Leu Ile Ala Glu Arg Glu Ala Met Lys Ser Ser 
        675                 680                 685             


Glu Leu Met Leu Glu Leu Gly Gly Ile Leu Arg Thr Phe Lys Phe Ile 
    690                 695                 700                 


Phe Arg Gly Thr Gly Tyr Asp Glu Lys Leu Val Arg Glu Val Glu Gly 
705                 710                 715                 720 


Leu Glu Ala Ser Gly Ser Val Tyr Ile Cys Thr Leu Cys Asp Ala Thr 
                725                 730                 735     


Arg Leu Glu Ala Ser Gln Asn Leu Val Phe His Ser Ile Thr Arg Ser 
            740                 745                 750         


His Ala Glu Asn Leu Glu Arg Tyr Glu Val Trp Arg Ser Asn Pro Tyr 
        755                 760                 765             


His Glu Ser Val Glu Glu Leu Arg Asp Arg Val Lys Gly Val Ser Ala 
    770                 775                 780                 


Lys Pro Phe Ile Glu Thr Val Pro Ser Ile Asp Ala Leu His Cys Asp 
785                 790                 795                 800 


Ile Gly Asn Ala Ala Glu Phe Tyr Lys Ile Phe Gln Leu Glu Ile Gly 
                805                 810                 815     


Glu Val Tyr Lys Asn Pro Asn Ala Ser Lys Glu Glu Arg Lys Arg Trp 
            820                 825                 830         


Gln Ala Thr Leu Asp Lys His Leu Arg Lys Lys Met Asn Leu Lys Pro 
        835                 840                 845             


Ile Met Arg Met Asn Gly Asn Phe Ala Arg Lys Leu Met Thr Lys Glu 
    850                 855                 860                 


Thr Val Asp Ala Val Cys Glu Leu Ile Pro Ser Glu Glu Arg His Glu 
865                 870                 875                 880 


Ala Leu Arg Glu Leu Met Asp Leu Tyr Leu Lys Met Lys Pro Val Trp 
                885                 890                 895     


Arg Ser Ser Cys Pro Ala Lys Glu Cys Pro Glu Ser Leu Cys Gln Tyr 
            900                 905                 910         


Ser Phe Asn Ser Gln Arg Phe Ala Glu Leu Leu Ser Thr Lys Phe Lys 
        915                 920                 925             


Tyr Arg Tyr Glu Gly Lys Ile Thr Asn Tyr Phe His Lys Thr Leu Ala 
    930                 935                 940                 


His Val Pro Glu Ile Ile Glu Arg Asp Gly Ser Ile Gly Ala Trp Ala 
945                 950                 955                 960 


Ser Glu Gly Asn Glu Ser Gly Asn Lys Leu Phe Arg Arg Phe Arg Lys 
                965                 970                 975     


Met Asn Ala Arg Gln Ser Lys Cys Tyr Glu Met Glu Asp Val Leu Lys 
            980                 985                 990         


His His Trp Leu Tyr Thr Ser Lys  Tyr Leu Gln Lys Phe  Met Asn Ala 
        995                 1000                 1005             


His Asn  Ala Leu Lys Thr Ser  Gly Phe Thr Met Asn  Pro Gln Ala 
    1010                 1015                 1020             


Ser Leu  Gly Asp Pro Leu Gly  Ile Glu Asp Ser Leu  Glu Ser Gln 
    1025                 1030                 1035             


Asp Ser  Met Glu Phe 
    1040             


<210>  55
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu 
        35                  40                  45              


Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe 
65                  70                  75                  80  


Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile 
            100                 105                 110         


Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn 
        275                 280                 285             


Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu 
            340                 345                 350         


Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro 
                485                 490                 495     


Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  56
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  56
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcggggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca g                                     511


<210>  57
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer for lentivirus backbone

<400>  57
agagatgggt gcgagagcgt ca                                                22


<210>  58
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer for lentivirus backbone

<400>  58
tgccttggtg ggtgctactc ctaa                                              24


<210>  59
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer for beta-actin

<400>  59
tcctgtggca tcgacgaaac t                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer for beta-actin

<400>  60
gaagcatttg cggtggacga t                                                 21


<210>  61
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  lentivirus-specific forward primer for PCR

<400>  61
tgaaagcgaa agggaaacca                                                   20


<210>  62
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  lentivirus-specific reverse primer for PCR

<400>  62
ccgtgcgcgc ttcag                                                        15


<210>  63
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  lentivirus-specific probe for PCR

<400>  63
agctctctcg acgcaggact cggc                                              24


<210>  64
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward beta-globin primer for PCR

<400>  64
cctatcagaa agtggtggct gg                                                22


<210>  65
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse beta-globin primer for PCR

<400>  65
ttggacagca agaaagtgag ctt                                               23


<210>  66
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  beta-globin probe for PCR

<400>  66
tggctaatgc cctggcccac aagta                                             25


