                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  SIALIDASE INHIBITORS AND PREPARATION THEREOF

<130>  1084249

<140>  PCT/US2018/029965
<141>  2018-04-27

<150>  US 62/491,038
<151>  2017-04-27

<150>  US 62/542,540
<151>  2017-08-08

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  739
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  1

Lys Lys Asn Ile Lys Gln Tyr Val Thr Leu Gly Thr Val Val Val Leu 
1               5                   10                  15      


Ser Ala Phe Val Ala Asn Ser Val Ala Ala Gln Glu Thr Glu Thr Ser 
            20                  25                  30          


Glu Val Ser Thr Pro Glu Leu Val Gln Pro Val Ala Pro Thr Thr Ser 
        35                  40                  45              


Ile Ser Glu Val Gln His Lys Ser Gly Asn Ser Ser Glu Val Thr Val 
    50                  55                  60                  


Gln Pro Arg Thr Val Glu Thr Thr Val Lys Asp Pro Ser Ser Thr Ala 
65                  70                  75                  80  


Glu Glu Thr Leu Val Leu Glu Lys Asn Asn Val Thr Leu Thr Gly Gly 
                85                  90                  95      


Gly Glu Asn Val Thr Lys Glu Leu Lys Asp Lys Phe Thr Ser Gly Asp 
            100                 105                 110         


Phe Thr Val Val Ile Lys Tyr Asn Gln Ser Ser Glu Lys Gly Leu Gln 
        115                 120                 125             


Ala Leu Phe Gly Ile Ser Asn Ser Lys Pro Gly Gln Gln Asn Ser Tyr 
    130                 135                 140                 


Val Asp Val Phe Leu Arg Asp Asn Gly Glu Leu Gly Met Glu Ala Arg 
145                 150                 155                 160 


Asp Thr Ser Ser Asn Lys Asn Asn Leu Val Ser Arg Pro Ala Ser Val 
                165                 170                 175     


Trp Gly Lys Tyr Lys Gln Glu Ala Val Thr Asn Thr Val Ala Val Val 
            180                 185                 190         


Ala Asp Ser Val Lys Lys Thr Tyr Ser Leu Tyr Ala Asn Gly Thr Lys 
        195                 200                 205             


Val Val Glu Lys Lys Val Asp Asn Phe Leu Asn Ile Lys Asp Ile Lys 
    210                 215                 220                 


Gly Ile Asp Tyr Tyr Met Leu Gly Gly Val Lys Arg Ala Gly Lys Thr 
225                 230                 235                 240 


Ala Phe Gly Phe Asn Gly Thr Leu Glu Asn Ile Lys Phe Phe Asn Ser 
                245                 250                 255     


Ala Leu Asp Glu Glu Thr Val Lys Lys Met Thr Thr Asn Ala Val Thr 
            260                 265                 270         


Gly His Leu Ile Tyr Thr Ala Asn Asp Thr Thr Gly Ser Asn Tyr Phe 
        275                 280                 285             


Arg Ile Pro Val Leu Tyr Thr Phe Ser Asn Gly Arg Val Phe Ser Ser 
    290                 295                 300                 


Ile Asp Ala Arg Tyr Gly Gly Thr His Asp Phe Leu Asn Lys Ile Asn 
305                 310                 315                 320 


Ile Ala Thr Ser Tyr Ser Asp Asp Asn Gly Lys Thr Trp Thr Lys Pro 
                325                 330                 335     


Lys Leu Thr Leu Ala Phe Asp Asp Phe Ala Pro Val Pro Leu Glu Trp 
            340                 345                 350         


Pro Arg Glu Val Gly Gly Arg Asp Leu Gln Ile Ser Gly Gly Ala Thr 
        355                 360                 365             


Tyr Ile Asp Ser Val Ile Val Glu Lys Lys Asn Lys Gln Val Leu Met 
    370                 375                 380                 


Phe Ala Asp Val Met Pro Ala Gly Val Ser Phe Arg Glu Ala Thr Arg 
385                 390                 395                 400 


Lys Asp Ser Gly Tyr Lys Gln Ile Asp Gly Asn Tyr Tyr Leu Lys Leu 
                405                 410                 415     


Arg Lys Gln Gly Asp Thr Asp Tyr Asn Tyr Thr Ile Arg Glu Asn Gly 
            420                 425                 430         


Thr Val Tyr Asp Asp Arg Thr Asn Arg Pro Thr Glu Phe Ser Val Asp 
        435                 440                 445             


Lys Asn Phe Gly Ile Lys Gln Asn Gly Asn Tyr Leu Thr Val Glu Gln 
    450                 455                 460                 


Tyr Ser Val Ser Phe Glu Asn Asn Lys Lys Thr Glu Tyr Arg Asn Gly 
465                 470                 475                 480 


Thr Lys Val His Met Asn Ile Phe Tyr Lys Asp Ala Leu Phe Lys Val 
                485                 490                 495     


Val Pro Thr Asn Tyr Ile Ala Tyr Ile Ser Ser Asn Asp His Gly Glu 
            500                 505                 510         


Ser Trp Ser Ala Pro Thr Leu Leu Pro Pro Ile Met Gly Leu Asn Arg 
        515                 520                 525             


Asn Ala Pro Tyr Leu Gly Pro Gly Arg Gly Ile Ile Glu Ser Ser Thr 
    530                 535                 540                 


Gly Arg Ile Leu Ile Pro Ser Tyr Thr Gly Lys Glu Ser Ala Phe Ile 
545                 550                 555                 560 


Tyr Ser Asp Asp Asn Gly Ala Ser Trp Lys Val Lys Val Val Pro Leu 
                565                 570                 575     


Pro Ser Ser Trp Ser Ala Glu Ala Gln Phe Val Glu Leu Ser Pro Gly 
            580                 585                 590         


Val Ile Gln Ala Tyr Met Arg Thr Asn Asn Gly Lys Ile Ala Tyr Leu 
        595                 600                 605             


Thr Ser Lys Asp Ala Gly Thr Thr Trp Ser Ala Pro Glu Tyr Leu Lys 
    610                 615                 620                 


Phe Val Ser Asn Pro Ser Tyr Gly Thr Gln Leu Ser Ile Ile Asn Tyr 
625                 630                 635                 640 


Ser Gln Leu Ile Asp Gly Lys Lys Ala Val Ile Leu Ser Thr Pro Asn 
                645                 650                 655     


Ser Thr Asn Gly Arg Lys His Gly Gln Ile Trp Ile Gly Leu Ile Asn 
            660                 665                 670         


Asp Asp Asn Thr Ile Asp Trp Arg Tyr His His Asp Val Asp Tyr Ser 
        675                 680                 685             


Asn Tyr Gly Tyr Ser Tyr Ser Thr Leu Thr Glu Leu Pro Asn His Glu 
    690                 695                 700                 


Ile Gly Leu Met Phe Glu Lys Phe Asp Ser Trp Ser Arg Asn Glu Leu 
705                 710                 715                 720 


His Met Lys Asn Val Val Pro Tyr Ile Thr Phe Lys Ile Glu Asp Leu 
                725                 730                 735     


Lys Lys Asn 
            


<210>  2
<211>  739
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  2

Lys Lys Asn Ile Lys Gln Tyr Val Thr Leu Gly Thr Val Val Val Leu 
1               5                   10                  15      


Ser Ala Phe Val Ala Asn Ser Val Ala Ala Gln Glu Thr Glu Thr Ser 
            20                  25                  30          


Glu Val Ser Thr Pro Lys Leu Val Gln Pro Val Ala Pro Thr Thr Pro 
        35                  40                  45              


Ile Ser Glu Val Gln Pro Thr Ser Asp Asn Ser Ser Glu Val Thr Val 
    50                  55                  60                  


Gln Pro Arg Thr Val Glu Thr Thr Val Lys Asp Pro Ser Ser Thr Ala 
65                  70                  75                  80  


Glu Glu Thr Pro Val Leu Glu Lys Asn Asn Val Thr Leu Thr Gly Gly 
                85                  90                  95      


Gly Glu Asn Val Thr Lys Glu Leu Lys Asp Lys Phe Thr Ser Gly Asp 
            100                 105                 110         


Phe Thr Val Val Ile Lys Tyr Asn Gln Ser Ser Glu Lys Gly Leu Gln 
        115                 120                 125             


Ala Leu Phe Gly Ile Ser Asn Ser Lys Pro Gly Gln Gln Asn Ser Tyr 
    130                 135                 140                 


Val Asp Val Phe Leu Arg Asp Asn Gly Glu Leu Gly Met Glu Ala Arg 
145                 150                 155                 160 


Asp Thr Ser Ser Asn Lys Asn Asn Leu Val Ser Arg Pro Ala Ser Val 
                165                 170                 175     


Trp Gly Lys Tyr Lys Gln Glu Ala Val Thr Asn Thr Val Ala Val Val 
            180                 185                 190         


Ala Asp Ser Val Lys Lys Thr Tyr Ser Leu Tyr Ala Asn Gly Thr Lys 
        195                 200                 205             


Val Val Glu Lys Lys Val Asp Asn Phe Leu Asn Ile Lys Asp Ile Lys 
    210                 215                 220                 


Gly Ile Asp Tyr Tyr Met Leu Gly Gly Val Lys Arg Ala Gly Lys Thr 
225                 230                 235                 240 


Ala Phe Gly Phe Asn Gly Thr Leu Glu Asn Ile Lys Phe Phe Asn Ser 
                245                 250                 255     


Ala Leu Asp Glu Glu Thr Val Lys Lys Met Thr Thr Asn Ala Val Thr 
            260                 265                 270         


Gly His Leu Ile Tyr Thr Ala Asn Asp Thr Thr Gly Ser Asn Tyr Phe 
        275                 280                 285             


Arg Ile Pro Val Leu Tyr Thr Phe Ser Asn Gly Arg Val Phe Ser Ser 
    290                 295                 300                 


Ile Asp Ala Arg Tyr Gly Gly Thr His Asp Phe Leu Asn Lys Ile Asn 
305                 310                 315                 320 


Ile Ala Thr Ser Tyr Ser Asp Asp Asn Gly Lys Thr Trp Thr Lys Pro 
                325                 330                 335     


Lys Leu Thr Leu Ala Phe Asp Asp Phe Ala Pro Val Pro Leu Glu Trp 
            340                 345                 350         


Pro Arg Glu Val Gly Gly Arg Asp Leu Gln Ile Ser Gly Gly Ala Thr 
        355                 360                 365             


Tyr Ile Asp Ser Val Ile Val Glu Lys Lys Asn Lys Gln Val Leu Met 
    370                 375                 380                 


Phe Ala Asp Val Met Pro Ala Gly Val Ser Phe Arg Glu Ala Thr Arg 
385                 390                 395                 400 


Lys Asp Ser Gly Tyr Lys Gln Ile Asp Gly Asn Tyr Tyr Leu Lys Leu 
                405                 410                 415     


Arg Lys Gln Gly Asp Thr Asp Tyr Asn Tyr Thr Ile Arg Glu Asn Gly 
            420                 425                 430         


Thr Val Tyr Asp Asp Arg Thr Asn Arg Pro Thr Glu Phe Ser Val Asp 
        435                 440                 445             


Lys Asn Phe Gly Ile Lys Gln Asn Gly Asn Tyr Leu Thr Val Glu Gln 
    450                 455                 460                 


Tyr Ser Val Ser Phe Glu Asn Asn Lys Lys Thr Glu Tyr Arg Asn Gly 
465                 470                 475                 480 


Thr Lys Val His Met Asn Ile Phe Tyr Lys Asp Ala Leu Phe Lys Val 
                485                 490                 495     


Val Pro Thr Asn Tyr Ile Ala Tyr Ile Ser Ser Asn Asp His Gly Glu 
            500                 505                 510         


Ser Trp Ser Ala Pro Thr Leu Leu Pro Pro Ile Met Gly Leu Asn Arg 
        515                 520                 525             


Asn Ala Pro Tyr Leu Gly Pro Gly Arg Gly Ile Ile Glu Ser Ser Thr 
    530                 535                 540                 


Gly Arg Ile Leu Ile Pro Ser Tyr Thr Gly Lys Glu Ser Ala Phe Ile 
545                 550                 555                 560 


Tyr Ser Asp Asp Asn Gly Ala Ser Trp Lys Val Lys Val Val Pro Leu 
                565                 570                 575     


Pro Ser Ser Trp Ser Ala Glu Ala Gln Phe Val Glu Leu Ser Pro Gly 
            580                 585                 590         


Val Ile Gln Ala Tyr Met Arg Thr Asn Asn Gly Lys Ile Ala Tyr Leu 
        595                 600                 605             


Thr Ser Lys Asp Ala Gly Thr Thr Trp Ser Ala Pro Glu Tyr Leu Lys 
    610                 615                 620                 


Phe Val Ser Asn Pro Ser Tyr Gly Thr Gln Leu Ser Ile Ile Asn Tyr 
625                 630                 635                 640 


Ser Gln Leu Ile Asp Gly Lys Lys Ala Val Ile Leu Ser Thr Pro Asn 
                645                 650                 655     


Ser Thr Asn Gly Arg Lys His Gly Gln Ile Trp Ile Gly Leu Ile Asn 
            660                 665                 670         


Asp Asp Asn Thr Ile Asp Trp Arg Tyr His His Asp Val Asp Tyr Ser 
        675                 680                 685             


Asn Tyr Gly Tyr Ser Tyr Ser Thr Leu Thr Glu Leu Pro Asn His Glu 
    690                 695                 700                 


Ile Gly Leu Met Phe Glu Lys Phe Asp Ser Trp Ser Arg Asn Glu Leu 
705                 710                 715                 720 


His Met Lys Asn Val Val Pro Tyr Ile Thr Phe Lys Ile Glu Asp Leu 
                725                 730                 735     


Lys Lys Asn 
            


<210>  3
<211>  668
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  3

Asn Glu Leu Asn Tyr Gly Gln Leu Ser Ile Ser Pro Ile Phe Gln Gly 
1               5                   10                  15      


Gly Ser Tyr Gln Leu Asn Asn Lys Ser Ile Asp Ile Ser Pro Leu Leu 
            20                  25                  30          


Leu Asp Lys Leu Ser Gly Asp Ser Gln Thr Val Val Met Lys Phe Lys 
        35                  40                  45              


Ala Asp Lys Pro Asn Ser Leu Gln Ala Leu Phe Gly Leu Ser Asn Ser 
    50                  55                  60                  


Lys Ala Gly Phe Lys Asn Asn Tyr Phe Ser Ile Phe Met Arg Asp Ser 
65                  70                  75                  80  


Gly Glu Ile Gly Val Glu Ile Arg Asp Ala Gln Lys Gly Ile Asn Tyr 
                85                  90                  95      


Leu Phe Ser Arg Pro Ala Ser Leu Trp Gly Lys His Lys Gly Gln Ala 
            100                 105                 110         


Val Glu Asn Thr Leu Val Phe Val Ser Asp Ser Lys Asp Lys Thr Tyr 
        115                 120                 125             


Thr Met Tyr Val Asn Gly Ile Glu Val Phe Ser Glu Thr Val Asp Thr 
    130                 135                 140                 


Phe Leu Pro Ile Ser Asn Ile Asn Gly Ile Asp Lys Ala Thr Leu Gly 
145                 150                 155                 160 


Ala Val Asn Arg Glu Gly Lys Glu His Tyr Leu Ala Lys Gly Ser Ile 
                165                 170                 175     


Asp Glu Ile Ser Leu Phe Asn Lys Ala Ile Ser Asp Gln Glu Val Ser 
            180                 185                 190         


Thr Ile Pro Leu Ser Asn Pro Phe Gln Leu Ile Phe Gln Ser Gly Asp 
        195                 200                 205             


Ser Thr Gln Ala Asn Tyr Phe Arg Ile Pro Thr Leu Tyr Thr Leu Ser 
    210                 215                 220                 


Ser Gly Arg Val Leu Ser Ser Ile Asp Ala Arg Tyr Gly Gly Thr His 
225                 230                 235                 240 


Asp Ser Lys Ser Lys Ile Asn Ile Ala Thr Ser Tyr Ser Asp Asp Asn 
                245                 250                 255     


Gly Lys Thr Trp Ser Glu Pro Ile Phe Ala Met Lys Phe Asn Asp Tyr 
            260                 265                 270         


Glu Glu Gln Leu Val Tyr Trp Pro Arg Asp Asn Lys Leu Lys Asn Ser 
        275                 280                 285             


Gln Ile Ser Gly Ser Ala Ser Phe Ile Asp Ser Ser Ile Val Glu Asp 
    290                 295                 300                 


Lys Lys Ser Gly Lys Thr Ile Leu Leu Ala Asp Val Met Pro Ala Gly 
305                 310                 315                 320 


Ile Gly Asn Asn Asn Ala Asn Lys Ala Asp Ser Gly Phe Lys Glu Ile 
                325                 330                 335     


Asn Gly His Tyr Tyr Leu Lys Leu Lys Lys Asn Gly Asp Asn Asp Phe 
            340                 345                 350         


Arg Tyr Thr Val Arg Glu Asn Gly Val Val Tyr Asp Glu Thr Thr Asn 
        355                 360                 365             


Lys Pro Thr Asn Tyr Thr Ile Asn Asp Lys Tyr Glu Val Leu Glu Gly 
    370                 375                 380                 


Gly Lys Ser Leu Thr Val Glu Gln Tyr Ser Val Asp Phe Asp Ser Gly 
385                 390                 395                 400 


Ser Leu Arg Glu Arg His Asn Gly Lys Gln Val Pro Met Asn Val Phe 
                405                 410                 415     


Tyr Lys Asp Ser Leu Phe Lys Val Thr Pro Thr Asn Tyr Ile Ala Met 
            420                 425                 430         


Thr Thr Ser Gln Asn Arg Gly Glu Ser Trp Glu Gln Phe Lys Leu Leu 
        435                 440                 445             


Pro Pro Phe Leu Gly Glu Lys His Asn Gly Thr Tyr Leu Cys Pro Gly 
    450                 455                 460                 


Gln Gly Leu Ala Leu Lys Ser Ser Asn Arg Leu Ile Phe Ala Thr Tyr 
465                 470                 475                 480 


Thr Ser Gly Glu Leu Thr Tyr Leu Ile Ser Asp Asp Ser Gly Gln Thr 
                485                 490                 495     


Trp Lys Lys Ser Ser Ala Ser Ile Pro Phe Glu Asn Ala Thr Ala Glu 
            500                 505                 510         


Ala Gln Met Val Glu Leu Arg Asp Gly Val Ile Arg Thr Phe Phe Arg 
        515                 520                 525             


Thr Thr Thr Gly Lys Ile Ala Tyr Met Thr Ser Arg Asp Ser Gly Glu 
    530                 535                 540                 


Thr Trp Ser Glu Val Ser Tyr Ile Asp Gly Ile Gln Gln Thr Ser Tyr 
545                 550                 555                 560 


Gly Thr Gln Val Ser Ala Ile Lys Tyr Ser Gln Leu Ile Asp Gly Lys 
                565                 570                 575     


Glu Ala Val Ile Leu Ser Thr Pro Asn Ser Arg Ser Gly Arg Lys Gly 
            580                 585                 590         


Gly Gln Leu Val Val Gly Leu Val Asn Lys Glu Asp Asp Ser Ile Asp 
        595                 600                 605             


Trp Lys Tyr His Tyr Asp Ile Asp Leu Pro Ser Tyr Gly Tyr Ala Tyr 
    610                 615                 620                 


Ser Ala Ile Thr Glu Leu Pro Asn His His Ile Gly Val Leu Phe Glu 
625                 630                 635                 640 


Lys Tyr Asp Ser Trp Ser Arg Asn Glu Leu His Leu Ser Asn Val Val 
                645                 650                 655     


Gln Tyr Ile Asp Leu Glu Ile Asn Asp Leu Thr Lys 
            660                 665             


<210>  4
<211>  387
<212>  PRT
<213>  Pasteurella multocida

<400>  4

Lys Thr Ile Thr Leu Tyr Leu Asp Pro Ala Ser Leu Pro Ala Leu Asn 
1               5                   10                  15      


Gln Leu Met Asp Phe Thr Gln Asn Asn Glu Asp Lys Thr His Pro Arg 
            20                  25                  30          


Ile Phe Gly Leu Ser Arg Phe Lys Ile Pro Asp Asn Ile Ile Thr Gln 
        35                  40                  45              


Tyr Gln Asn Ile His Phe Val Glu Leu Lys Asp Asn Arg Pro Thr Glu 
    50                  55                  60                  


Ala Leu Phe Thr Ile Leu Asp Gln Tyr Pro Gly Asn Ile Glu Leu Asn 
65                  70                  75                  80  


Ile His Leu Asn Ile Ala His Ser Val Gln Leu Ile Arg Pro Ile Leu 
                85                  90                  95      


Ala Tyr Arg Phe Lys His Leu Asp Arg Val Ser Ile Gln Gln Leu Asn 
            100                 105                 110         


Leu Tyr Asp Asp Gly Ser Asp Glu Tyr Val Asp Leu Glu Lys Glu Glu 
        115                 120                 125             


Asn Lys Asp Ile Ser Ala Glu Ile Lys Gln Ala Glu Lys Gln Leu Ser 
    130                 135                 140                 


His Tyr Leu Leu Thr Gly Lys Ile Lys Phe Asp Asn Pro Thr Ile Ala 
145                 150                 155                 160 


Arg Tyr Val Trp Gln Ser Ala Phe Pro Val Lys Tyr His Phe Leu Ser 
                165                 170                 175     


Thr Asp Tyr Phe Glu Lys Ala Glu Phe Leu Gln Pro Leu Lys Glu Tyr 
            180                 185                 190         


Leu Ala Glu Asn Tyr Gln Lys Met Asp Trp Thr Ala Tyr Gln Gln Leu 
        195                 200                 205             


Thr Pro Glu Gln Gln Ala Phe Tyr Leu Thr Leu Val Gly Phe Asn Asp 
    210                 215                 220                 


Glu Val Lys Gln Ser Leu Glu Val Gln Gln Ala Lys Phe Ile Phe Thr 
225                 230                 235                 240 


Gly Thr Thr Thr Trp Glu Gly Asn Thr Asp Val Arg Glu Tyr Tyr Ala 
                245                 250                 255     


Gln Gln Gln Leu Asn Leu Leu Asn His Phe Thr Gln Ala Glu Gly Asp 
            260                 265                 270         


Leu Phe Ile Gly Asp His Tyr Lys Ile Tyr Phe Lys Gly His Pro Arg 
        275                 280                 285             


Gly Gly Glu Ile Asn Asp Tyr Ile Leu Asn Asn Ala Lys Asn Ile Thr 
    290                 295                 300                 


Asn Ile Pro Ala Asn Ile Ser Phe Glu Val Leu Met Met Thr Gly Leu 
305                 310                 315                 320 


Leu Pro Asp Lys Val Gly Gly Val Ala Ser Ser Leu Tyr Phe Ser Leu 
                325                 330                 335     


Pro Lys Glu Lys Ile Ser His Ile Ile Phe Thr Ser Asn Lys Gln Val 
            340                 345                 350         


Lys Ser Lys Glu Asp Ala Leu Asn Asn Pro Tyr Val Lys Val Met Arg 
        355                 360                 365             


Arg Leu Gly Ile Ile Asp Glu Ser Gln Val Ile Phe Trp Asp Ser Leu 
    370                 375                 380                 


Lys Gln Leu 
385         


<210>  5
<211>  307
<212>  PRT
<213>  Pasteurella multocida

<400>  5

Asn Leu Ile Ile Cys Cys Thr Pro Leu Gln Val Leu Ile Ala Glu Lys 
1               5                   10                  15      


Ile Ile Ala Lys Phe Pro His Thr Pro Phe Tyr Gly Val Met Leu Ser 
            20                  25                  30          


Thr Val Ser Asn Lys Lys Phe Asp Phe Tyr Ala Lys Arg Leu Ala Gln 
        35                  40                  45              


Gln Cys Gln Gly Phe Phe Ser Met Val Gln His Lys Asp Arg Phe Asn 
    50                  55                  60                  


Leu Leu Lys Glu Ile Leu Tyr Leu Lys Arg Thr Phe Ser Gly Lys His 
65                  70                  75                  80  


Phe Asp Gln Val Phe Val Ala Asn Ile Asn Asp Leu Gln Ile Gln Phe 
                85                  90                  95      


Leu Leu Ser Ala Ile Asp Phe Asn Leu Leu Asn Thr Phe Asp Asp Gly 
            100                 105                 110         


Thr Ile Asn Ile Val Pro Asn Ser Leu Phe Tyr Gln Asp Asp Pro Ala 
        115                 120                 125             


Thr Leu Gln Arg Lys Leu Ile Asn Val Leu Leu Gly Asn Lys Tyr Ser 
    130                 135                 140                 


Ile Gln Ser Leu Arg Ala Leu Ser His Thr His Tyr Thr Ile Tyr Lys 
145                 150                 155                 160 


Gly Phe Lys Asn Ile Ile Glu Arg Val Glu Pro Ile Glu Leu Val Ala 
                165                 170                 175     


Ala Asp Asn Ser Glu Lys Val Thr Ser Ala Val Ile Asn Val Leu Leu 
            180                 185                 190         


Gly Gln Pro Val Phe Ala Glu Asp Glu Arg Asn Ile Ala Leu Ala Glu 
        195                 200                 205             


Arg Val Ile Lys Gln Phe Asn Ile His Tyr Tyr Leu Pro His Pro Arg 
    210                 215                 220                 


Glu Lys Tyr Arg Leu Ala Gln Val Asn Tyr Ile Asp Thr Glu Leu Ile 
225                 230                 235                 240 


Phe Glu Asp Tyr Ile Leu Gln Gln Cys Gln Thr His Lys Tyr Cys Val 
                245                 250                 255     


Tyr Thr Tyr Phe Ser Ser Ala Ile Ile Asn Ile Met Asn Lys Ser Asp 
            260                 265                 270         


Asn Ile Glu Val Val Ala Leu Lys Ile Asp Thr Glu Asn Pro Ala Tyr 
        275                 280                 285             


Asp Ala Cys Tyr Asp Leu Phe Asp Glu Leu Gly Val Asn Val Ile Asp 
    290                 295                 300                 


Ile Arg Glu 
305         


<210>  6
<211>  266
<212>  PRT
<213>  Pasteurella multocida

<400>  6

Asp Lys Phe Ala Glu His Glu Ile Pro Lys Ala Val Ile Val Ala Gly 
1               5                   10                  15      


Asn Gly Glu Ser Leu Ser Gln Ile Asp Tyr Arg Leu Leu Pro Lys Asn 
            20                  25                  30          


Tyr Asp Val Phe Arg Cys Asn Gln Phe Tyr Phe Glu Glu Arg Tyr Phe 
        35                  40                  45              


Leu Gly Asn Lys Ile Lys Ala Val Phe Phe Thr Pro Gly Val Phe Leu 
    50                  55                  60                  


Glu Gln Tyr Tyr Thr Leu Tyr His Leu Lys Arg Asn Asn Glu Tyr Phe 
65                  70                  75                  80  


Val Asp Asn Val Ile Leu Ser Ser Phe Asn His Pro Thr Val Asp Leu 
                85                  90                  95      


Glu Lys Ser Gln Lys Ile Gln Ala Leu Phe Ile Asp Val Ile Asn Gly 
            100                 105                 110         


Tyr Glu Lys Tyr Leu Ser Lys Leu Thr Ala Phe Asp Val Tyr Leu Arg 
        115                 120                 125             


Tyr Lys Glu Leu Tyr Glu Asn Gln Arg Ile Thr Ser Gly Val Tyr Met 
    130                 135                 140                 


Cys Ala Val Ala Ile Ala Met Gly Tyr Thr Asp Ile Tyr Leu Thr Gly 
145                 150                 155                 160 


Ile Asp Phe Tyr Gln Ala Ser Glu Glu Asn Tyr Ala Phe Asp Asn Lys 
                165                 170                 175     


Lys Pro Asn Ile Ile Arg Leu Leu Pro Asp Phe Arg Lys Glu Lys Thr 
            180                 185                 190         


Leu Phe Ser Tyr His Ser Lys Asp Ile Asp Leu Glu Ala Leu Ser Phe 
        195                 200                 205             


Leu Gln Gln His Tyr His Val Asn Phe Tyr Ser Ile Ser Pro Met Ser 
    210                 215                 220                 


Pro Leu Ser Lys His Phe Pro Ile Pro Thr Val Glu Asp Asp Cys Glu 
225                 230                 235                 240 


Thr Thr Phe Val Ala Pro Leu Lys Glu Asn Tyr Ile Asn Asp Ile Leu 
                245                 250                 255     


Leu Val Asp Lys Leu Ala Ala Ala Leu Glu 
            260                 265     


<210>  7
<211>  227
<212>  PRT
<213>  Neisseria meningitidis

<400>  7

Glu Lys Gln Asn Ile Ala Val Ile Leu Ala Arg Gln Asn Ser Lys Gly 
1               5                   10                  15      


Leu Pro Leu Lys Asn Leu Arg Lys Met Asn Gly Ile Ser Leu Leu Gly 
            20                  25                  30          


His Thr Ile Asn Ala Ala Ile Ser Ser Lys Cys Phe Asp Arg Ile Ile 
        35                  40                  45              


Val Ser Thr Asp Gly Gly Leu Ile Ala Glu Glu Ala Lys Asn Phe Gly 
    50                  55                  60                  


Val Glu Val Val Leu Arg Pro Ala Glu Leu Ala Ser Asp Thr Ala Ser 
65                  70                  75                  80  


Ser Ile Ser Gly Val Ile His Ala Leu Glu Thr Ile Gly Ser Asn Ser 
                85                  90                  95      


Gly Thr Val Thr Leu Leu Gln Pro Thr Ser Pro Leu Arg Thr Gly Ala 
            100                 105                 110         


His Ile Arg Glu Ala Phe Ser Leu Phe Asp Glu Lys Ile Lys Gly Ser 
        115                 120                 125             


Val Val Ser Ala Cys Pro Met Glu His His Pro Leu Lys Thr Leu Leu 
    130                 135                 140                 


Gln Ile Asn Asn Gly Glu Tyr Ala Pro Met Arg His Leu Ser Asp Leu 
145                 150                 155                 160 


Glu Gln Pro Arg Gln Gln Leu Pro Gln Ala Phe Arg Pro Asn Gly Ala 
                165                 170                 175     


Ile Tyr Ile Asn Asp Thr Ala Ser Leu Ile Ala Asn Asn Cys Phe Phe 
            180                 185                 190         


Ile Ala Pro Thr Lys Leu Tyr Ile Met Ser His Gln Asp Ser Ile Asp 
        195                 200                 205             


Ile Asp Thr Glu Leu Asp Leu Gln Gln Ala Glu Asn Ile Leu His His 
    210                 215                 220                 


Lys Glu Ser 
225         


<210>  8
<211>  222
<212>  PRT
<213>  Pasteurella multocida

<400>  8

Thr Asn Ile Ala Ile Ile Pro Ala Arg Ala Gly Ser Lys Gly Ile Pro 
1               5                   10                  15      


Asp Lys Asn Leu Gln Pro Val Gly Gly His Ser Leu Ile Gly Arg Ala 
            20                  25                  30          


Ile Leu Ala Ala Lys Asn Ala Asp Val Phe Asp Met Ile Val Val Thr 
        35                  40                  45              


Ser Asp Gly Asp Asn Ile Leu Arg Glu Ala Glu Lys Tyr Gly Ala Leu 
    50                  55                  60                  


Ala Leu Lys Arg Pro Ala Glu Leu Ala Gln Asp Asn Ser Arg Thr Ile 
65                  70                  75                  80  


Asp Ala Ile Leu His Ala Leu Glu Ser Leu Asn Ile Arg Glu Gly Thr 
                85                  90                  95      


Cys Thr Leu Leu Gln Pro Thr Ser Pro Leu Arg Asp His Leu Asp Ile 
            100                 105                 110         


Lys Asn Ala Met Asp Met Tyr Val Asn Gly Gly Val His Ser Val Val 
        115                 120                 125             


Ser Ala Cys Glu Cys Glu His His Pro Tyr Lys Ala Phe Ala Leu Ser 
    130                 135                 140                 


Lys Asp His Glu Val Leu Pro Val Arg Glu Ile Ala Asp Phe Glu Ala 
145                 150                 155                 160 


Val Arg Gln Thr Leu Pro Lys Met Tyr Arg Ala Asn Gly Ala Ile Tyr 
                165                 170                 175     


Ile Asn Asp Ile Ala Gln Leu Leu Lys Glu Lys Tyr Phe Phe Ile Pro 
            180                 185                 190         


Pro Leu Lys Phe Tyr Leu Met Pro Thr Tyr His Ser Val Asp Ile Asp 
        195                 200                 205             


Val Lys Gln Asp Leu Glu Leu Ala Glu Ile Leu Ser Asn Lys 
    210                 215                 220         


<210>  9
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
gatcgaattc atgaaaaaaa atattaaaca atatg                                  35


<210>  10
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
acgcaagctt ttagtggtgg tggtggtggt gattcttttt cagatcttc                   49


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
gatcgaattc ggctcaggag actgaaactt                                        30


<210>  12
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
acgcctcgag attctttttc agatcttcaa tc                                     32


