                         SEQUENCE LISTING

<110>  The Schepens Eye Research Institute, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR REDUCING CORNEAL ENDOTHELIAL CELL 
       LOSS

<130>  036770-560001WO

<150>  62/491,694
<151>  2017-04-28

<150>  62/491,671
<151>  2017-04-28

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  2
<211>  1436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes the human POMC preprotein.

<400>  2
gttctaagcg gagacccaac gccatccata attaagttct tcctgagggc gagcggccag       60

gtgcgccttc ggcaggacag tgctaattcc agcccctttc cagcgcgtct ccccgcgctc      120

gtcccccgtc tggaagcccc cctcccacgc cccgcggccc cccttcccct ggcccgggga      180

gctgctcctt gtgctgccgg gaaggtcaaa gtcccgcgcc caccaggaga gctcggcaag      240

tatataagga cagaggagcg cgggaccaag cggcggcgaa ggaggggaag aagagccgcg      300

accgagagag gccgccgagc gtccccgccc tcagagagca gcctcccgag acaggggtcc      360

caccaatctt gtttgcttct gcagagcctc agcctgcctg gaagatgccg agatcgtgct      420

gcagccgctc gggggccctg ttgctggcct tgctgcttca ggcctccatg gaagtgcgtg      480

gctggtgcct ggagagcagc cagtgtcagg acctcaccac ggaaagcaac ctgctggagt      540

gcatccgggc ctgcaagccc gacctctcgg ccgagactcc catgttcccg ggaaatggcg      600

acgagcagcc tctgaccgag aacccccgga agtacgtcat gggccacttc cgctgggacc      660

gattcggccg ccgcaacagc agcagcagcg gcagcagcgg cgcagggcag aagcgcgagg      720

acgtctcagc gggcgaagac tgcggcccgc tgcctgaggg cggccccgag ccccgcagcg      780

atggtgccaa gccgggcccg cgcgagggca agcgctccta ctccatggag cacttccgct      840

ggggcaagcc ggtgggcaag aagcggcgcc cagtgaaggt gtaccctaac ggcgccgagg      900

acgagtcggc cgaggccttc cccctggagt tcaagaggga gctgactggc cagcgactcc      960

gggagggaga tggccccgac ggccctgccg atgacggcgc aggggcccag gccgacctgg     1020

agcacagcct gctggtggcg gccgagaaga aggacgaggg cccctacagg atggagcact     1080

tccgctgggg cagcccgccc aaggacaagc gctacggcgg tttcatgacc tccgagaaga     1140

gccagacgcc cctggtgacg ctgttcaaaa acgccatcat caagaacgcc tacaagaagg     1200

gcgagtgagg gcacagcggg gccccagggc taccctcccc caggaggtcg accccaaagc     1260

cccttgctct cccctgccct gctgccgcct cccagcctgg ggggtcgtgg cagataatca     1320

gcctcttaaa gctgcctgta gttaggaaat aaaacctttc aaatttcaca tccacctctg     1380

actttgaatg taaactgtgt gaataaagta aaaatacgta gccgtcaaat aacagc         1436


<210>  3
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile 
            20                  25                  30          


Pro Gln Ala His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 
        35                  40                  45              


Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala 
    50                  55                  60                  


Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 
65                  70                  75                  80  


Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu 
                85                  90                  95      


Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro 
            100                 105                 110         


Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe 
        115                 120                 125             


His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly 
    130                 135                 140                 


Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu 
145                 150                 155                 160 


Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val 
        195                 200                 205             


Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg 
    210                 215                 220                 


Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val Arg Arg 
225                 230                 235                 240 


Ala 
    


<210>  4
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes human NGF.

<400>  4
atgtccatgt tgttctacac tctgatcaca gcttttctga tcggcataca ggcggaacca       60

cactcagaga gcaatgtccc tgcaggacac accatccccc aagcccactg gactaaactt      120

cagcattccc ttgacactgc ccttcgcaga gcccgcagcg ccccggcagc ggcgatagct      180

gcacgcgtgg cggggcagac ccgcaacatt actgtggacc ccaggctgtt taaaaagcgg      240

cgactccgtt caccccgtgt gctgtttagc acccagcctc cccgtgaagc tgcagacact      300

caggatctgg acttcgaggt cggtggtgct gcccccttca acaggactca caggagcaag      360

cggtcatcat cccatcccat cttccacagg ggcgaattct cggtgtgtga cagtgtcagc      420

gtgtgggttg gggataagac caccgccaca gacatcaagg gcaaggaggt gatggtgttg      480

ggagaggtga acattaacaa cagtgtattc aaacagtact tttttgagac caagtgccgg      540

gacccaaatc ccgttgacag cgggtgccgg ggcattgact caaagcactg gaactcatat      600

tgtaccacga ctcacacctt tgtcaaggcg ctgaccatgg atggcaagca ggctgcctgg      660

cggtttatcc ggatagatac ggcctgtgtg tgtgtgctca gcaggaaggc tgtgagaaga      720

gcctga                                                                 726


<210>  5
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Thr Arg Asn Lys Ala Gln Leu Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Val Leu Phe Ser Gln Thr Ser Ala Trp Pro Leu Tyr Arg Ala Pro 
            20                  25                  30          


Ser Ala Leu Arg Leu Gly Asp Arg Ile Pro Phe Glu Gly Ala Asn Glu 
        35                  40                  45              


Pro Asp Gln Val Ser Leu Lys Glu Asp Ile Asp Met Leu Gln Asn Ala 
    50                  55                  60                  


Leu Ala Glu Asn Asp Thr Pro Tyr Tyr Asp Val Ser Arg Asn Ala Arg 
65                  70                  75                  80  


His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
                85                  90                  95      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met Gly Lys Arg Val Ser 
            100                 105                 110         


Ser Asn Ile Ser Glu Asp Pro Val Pro Val Lys Arg His Ser Asp Ala 
        115                 120                 125             


Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln Met Ala Val Lys 
    130                 135                 140                 


Lys Tyr Leu Asn Ser Ile Leu Asn Gly Lys Arg Ser Ser Glu Gly Glu 
145                 150                 155                 160 


Ser Pro Asp Phe Pro Glu Glu Leu Glu Lys 
                165                 170 


<210>  6
<211>  1511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes human VIP.

<400>  6
ggtcagctcc aaaacaatcc ggaacggcca gctccggggg agcacgactg ggcgagaggc       60

acagaaatgg acaccagaaa taaggcccag ctccttgtgc tcctgactct tctcagtgtg      120

ctcttctcac agacttcggc atggcctctt tacagggcac cttctgctct caggttgggt      180

gacagaatac cctttgaggg agcaaatgaa cctgatcaag tttcattaaa agaagacatt      240

gacatgttgc aaaatgcatt agctgaaaat gacacaccct attatgatgt atccagaaat      300

gccaggcatg ctgatggagt tttcaccagt gacttcagta aactcttggg tcaactttct      360

gccaaaaagt accttgagtc tcttatggga aaacgtgtta gcagtaacat ctcagaagac      420

cctgtaccag tcaaacgtca ctcagatgca gtcttcactg acaactatac ccgccttaga      480

aaacaaatgg ctgtaaagaa atatttgaac tcaattctga atggaaagag gagcagtgag      540

ggagaatctc ccgactttcc agaagagtta gaaaaatgat gaaaaagacc tttggagcaa      600

agctgatgac aacttcccag tgaattcttg aaggaaaatg atacgcaaca taattaaatt      660

ttagattcta cataagtaat tcaagaaaac aacttcaata tccaaaccaa ataaaaatat      720

tgtgttgtga atgttgtgat gtattctagc taatgtaata actgtgaagt ttacattgta      780

aatagtattt gagagttcta aattttgtct ttaactcata aaaagcctgc aatttcatat      840

gctgtatatc ctttctaaca aaaaaatata ttttaatgat aagtaatgct aggttaatcc      900

aattatatga gacgtttttg gaagagtagt aatagagcaa aattgatgtg tttatttata      960

gagtgtactt aactattcag gagagtagaa cagataatca gtgtgtctaa atttgaatgt     1020

taagcagatg gaatgctgtg ttaaataaac ctcaaaatgt ctaagatagt aacaatgaag     1080

ataaaaagac attcttccaa aaagattttc agaaaatatt atgtgtttcc atattttata     1140

ggcaaccttt atttttaatg gtgttttaaa aaatctcaaa tttggattgc taatcaccaa     1200

aggctctctc ctgatagtct ttcagttaag gagaacgacc cctgcttctg acactgaaac     1260

ttccctttct gcttgtgtta agtatgtgta aaatgtgaag tgaatgaaac actcagttgt     1320

tcaataataa atatttttgc cataatgact cagaatattg ctttggtcat atgagcttcc     1380

ttctgtgaaa tacattttgg agacacaact atttttccaa aataatttta agaaatcaaa     1440

gagagaaaat aaagaccttg cttatgattg cagataaaaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa a                                                          1511


<210>  7
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asn Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Arg Ile Ile Ala Gln 
65                  70                  75                  80  


Lys Arg Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly 
                85                  90                  95      


Leu Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr 
            100                 105                 110         


Asn Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125             


<210>  8
<211>  916
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes human CGRP.

<400>  8
ccgccgctgc caccgcctct gatccaagcc acctcccgcc aggtgagccc cgagatcctg       60

gctcagagag gtgtcatggg cttccaaaag ttctccccct tcctggctct cagcatcttg      120

gtcctgttgc aggcaggcag cctccatgca gcaccattca ggtctgccct ggagagcagc      180

ccagcagacc cggccacgct cagtgaggac gaagcgcgcc tcctgctggc tgcactggtg      240

caggactatg tgcagatgaa ggccagtgag ctggagcagg agcaagagag agagggctcc      300

agaatcattg cccagaagag agcctgtgac actgccacct gtgtgactca tcggctggca      360

ggcttgctga gcagatcagg gggtgtggtg aagaacaact ttgtgcccac caatgtgggt      420

tccaaagcct ttggcaggcg ccgcagggac cttcaagcct gagcagctga atgactcaag      480

aaggtcacaa taaagctgaa ctccttttaa tgtgtaatga aagcaatttg taggaaaggc      540

tccatggaag acatacatat aggcatcctt cttgatactg aaaactatct tctttgtttg      600

aaaggaacta ttgctaaatg cagaacaagc tcattgcagt tacctattgt gcatcttttt      660

aaatacttga ttatgtaacc ataaatctga cagcatgtct cattggctta tctggtagca      720

aatctaggcc ccgtcagcca ccctattgac attggtggct ctgctaaacc tcagggggac      780

atgaaatcac tgcctcttgg gcatctgggg acacatggta atgctgtgcc ttgacagaag      840

tatttgttta aagaaatgtc aatgctgtca tttgtgaact ctatcaaaat taaaaatgta      900

ttttctatac ccttca                                                      916


<210>  9
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  10
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes human BDNF.

<400>  10
gaattcgggg ctgccgccgc cgcgcccggg cgcacccgcc cgctcgctgt cccgcgcacc       60

ccgtagcgcc tcgggctccc gggccggaca gaggagccag cccggtgcgc ccctccacct      120

cctgctcggg gggctttaat gagacaccca ccgctgctgt ggggccggcg gggagcagca      180

ccgcgacggg gaccggggct gggcgctgga gccagaatcg gaaccacgat gtgactccgc      240

cgccggggac ccgtgaggtt tgtgtggacc ccgagttcca ccaggtgaga agagtgatga      300

ccatcctttt ccttactatg gttatttcat actttggttg catgaaggct gcccccatga      360

aagaagcaaa catccgagga caaggtggct tggcctaccc aggtgtgcgg acccatggga      420

ctctggagag cgtgaatggg cccaaggcag gttcaagagg cttgacatca ttggctgaca      480

ctttcgaaca cgtgatagaa gagctgttgg atgaggacca gaaagttcgg cccaatgaag      540

aaaacaataa ggacgcagac ttgtacacgt ccagggtgat gctcagtagt caagtgcctt      600

tggagcctcc tcttctcttt ctgctggagg aatacaaaaa ttacctagat gctgcaaaca      660

tgtccatgag ggtccggcgc cactctgacc ctgcccgccg aggggagctg agcgtgtgtg      720

acagtattag tgagtgggta acggcggcag acaaaaagac tgcagtggac atgtcgggcg      780

ggacggtcac agtccttgaa aaggtccctg tatcaaaagg ccaactgaag caatacttct      840

acgagaccaa gtgcaatccc atgggttaca caaaagaagg ctgcaggggc atagacaaaa      900

ggcattggaa ctcccagtgc cgaactaccc agtcgtacgt gcgggccctt accatggata      960

gcaaaaagag aattggctgg cgattcataa ggatagacac ttcttgtgta tgtacattga     1020

ccattaaaag gggaagatag tggatttatg ttgtatagat tagattatat tgagacaaaa     1080

attatctatt tgtatatata cataacaggg taaattattc agttaagaaa aaaataattt     1140

tatgaactgc atgtataaat gaagtttata cagtacagtg gttctacaat ctatttattg     1200

gacatgtcca tgaccagaag ggaaacagtc atttgcgcac aacttaaaaa gtctgcatta     1260

cattccttga taatgttgtg gtttgttgcc gttgccaaga actgaaaaca taaaaagtta     1320

aaaaaaataa taaattgcat gctgcccgaa ttc                                  1353


<210>  11
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  12
<211>  1034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes human neurotrophin-3.

<400>  12
cacactcagc tgccagagcc tgctcttaac acctgtgttt ccttttcaga tcttacaggt       60

gaacaaggtg atgtccatct tgttttatgt gatatttctc gcttatctcc gtggcatcca      120

aggtaacaac atggatcaaa ggagtttgcc agaagactcg ctcaattccc tcattattaa      180

gctgatccag gcagatattt tgaaaaacaa gctctccaag cagatggtgg acgttaagga      240

aaattaccag agcaccctgc ccaaagctga ggctccccga gagccggagc ggggagggcc      300

cgccaagtca gcattccagc cagtgattgc aatggacacc gaactgctgc gacaacagag      360

acgctacaac tcaccgcggg tcctgctgag cgacagcacc cccttggagc ccccgccctt      420

gtatctcatg gaggattacg tgggcagccc cgtggtggcg aacagaacat cacggcggaa      480

acggtacgcg gagcataaga gtcaccgagg ggagtactcg gtatgtgaca gtgagagtct      540

gtgggtgacc gacaagtcat cggccatcga cattcgggga caccaggtca cggtgctggg      600

ggagatcaaa acgggcaact ctcctgtcaa acaatatttt tatgaaacgc gatgtaagga      660

agccaggccg gtcaaaaacg gttgcagggg tattgatgat aaacactgga actctcagtg      720

caaaacatcc caaacctacg tccgagcact gacttcagag aacaataaac tcgtgggctg      780

gcggtggata cggatagaca cgtcctgtgt gtgtgccttg tcgagaaaaa tcggaagaac      840

atgaattggc atctctcccc atatataaat tattacttta aattatatga tatgcatgta      900

gcatataaat gtttatattg tttttatata ttataagttg acctttattt attaaacttc      960

agcaacccta cagtatataa gcttttttct caataaaatc agtgtgcttg ccttccctca     1020

ggcctctccc atct                                                       1034


<210>  13
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 
            20                  25                  30          


Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 
        35                  40                  45              


Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 
    50                  55                  60                  


Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 
65                  70                  75                  80  


Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 
                85                  90                  95      


Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 
            100                 105                 110         


Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 
        115                 120                 125             


Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 
    130                 135                 140                 


Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 
145                 150                 155                 160 


Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 
                165                 170                 175     


Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 
            180                 185                 190         


Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 
        195                 200                 205             


Arg Ala 
    210 


<210>  14
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes human NTF-4.

<400>  14
atgcttcctc tcccctcatg ctccctcccc atcctcctcc ttttcctcct ccccagtgtg       60

ccaattgagt cccaaccccc accctcaaca ttgccccctt ttctggcccc tgagtgggac      120

cttctctccc cccgagtagt cctgtctagg ggtgcccctg ctgggccccc tctgctcttc      180

ctgctggagg ctggggcctt tcgggagtca gcaggtgccc cggccaaccg cagccggcgt      240

ggggtgagcg aaactgcacc agcgagtcgt cggggtgagc tggctgtgtg cgatgcagtc      300

agtggctggg tgacagaccg ccggaccgct gtggacttgc gtgggcgcga ggtggaggtg      360

ttgggcgagg tgcctgcagc tggcggcagt cccctccgcc agtacttctt tgaaacccgc      420

tgcaaggctg ataacgctga ggaaggtggc ccgggggcag gtggaggggg ctgccgggga      480

gtggacagga ggcactgggt atctgagtgc aaggccaagc agtcctatgt gcgggcattg      540

accgctgatg cccagggccg tgtgggctgg cgatggattc gaattgacac tgcctgcgtc      600

tgcacactcc tcagccggac tggccgagcc tag                                   633


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 
1               5                   10      


<210>  16
<211>  1134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence that encodes a precursor of human substance 
       P.

<400>  16
cacgcaagcg aaaggagagg aggcggctaa ttaaatattg agcagaaagt cgcgtgggga       60

gaatgtcacg tgggtctgga ggctcaagga ggctgggata aataccgcaa ggcactgagc      120

aggcgaaaga gcgcgctcgg acctccttcc cggcggcagc taccgagagt gcggagcgac      180

cagcgtgcgc tcggaggaac cagagaaact cagcaccccg cgggactgtc cgtcgcaaaa      240

tccaacatga aaatcctcgt ggccttggca gtcttttttc ttgtctccac tcagctgttt      300

gcagaagaaa taggagccaa tgatgatctg aattactggt ccgactggta cgacagcgac      360

cagatcaagg aggaactgcc ggagcccttt gagcatcttc tgcagagaat cgcccggaga      420

cccaagcctc agcagttctt tggattaatg ggcaaacggg atgctgattc ctcaattgaa      480

aaacaagtgg ccctgttaaa ggctctttat ggacatggcc agatctctca caaaatggct      540

tatgaaagga gtgcaatgca gaattatgaa agaagacgtt aataaactac ctaacattat      600

ttattcagct tcatttgtgt caatgggcaa tgacaggtaa attaagacat gcactatgag      660

gaataattat ttatttaata acaattgttt ggggttgaaa attcaaaaag tgtttatttt      720

tcatattgtg ccaatatgta ttgtaaacat gtgttttaat tccaatatga tgactccctt      780

aaaatagaaa taagtggtta tttctcaaca aagcacagtg ttaaatgaaa ttgtaaaacc      840

tgtcaatgat acagtcccta aagaaaaaaa atcattgctt tgaagcagtt gtgtcagcta      900

ctgcggaaaa ggaaggaaac tcctgacagt cttgtgcttt tcctatttgt tttcatggtg      960

aaaatgtact gagattttgg tattacactg tatttgtatc tctgaagcat gtttcatgtt     1020

ttgtgactat atagagatgt ttttaaaagt ttcaatgtga ttctaatgtc ttcatttcat     1080

tgtatgatgt gttgtgatag ctaacatttt aaataaaaga aaaaatatct tgaa           1134


