                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING
        THE SAME

<130>  01017/51689A

<150>  US 62/492,056
<151>  2017-04-28

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab variable light chain

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab variable heavy chain

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab full length light chain

<400>  3

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Arg Gly Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  4
<211>  467
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  denosumab full length heavy chain

<400>  4

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR 1

<400>  5

Arg Ala Ser Gln Ser Val Arg Gly Arg Tyr Leu Ala 
1               5                   10          


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR 2

<400>  6

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR 3

<400>  7

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR 1

<400>  8

Ser Tyr Ala Met Ser 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR 2

<400>  9

Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR 3

<400>  10

Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro 
1               5                   10              


<210>  11
<211>  2141
<212>  DNA
<213>  Homo sapiens

<400>  11
ggccaaagcc gggctccaag tcggcgcccc acgtcgaggc tccgccgcag cctccggagt       60

tggccgcaga caagaagggg agggagcggg agagggagga gagctccgaa gcgagagggc      120

cgagcgccat gcgccgcgcc agcagagact acaccaagta cctgcgtggc tcggaggaga      180

tgggcggcgg ccccggagcc ccgcacgagg gccccctgca cgccccgccg ccgcctgcgc      240

cgcaccagcc ccccgccgcc tcccgctcca tgttcgtggc cctcctgggg ctggggctgg      300

gccaggttgt ctgcagcgtc gccctgttct tctatttcag agcgcagatg gatcctaata      360

gaatatcaga agatggcact cactgcattt atagaatttt gagactccat gaaaatgcag      420

attttcaaga cacaactctg gagagtcaag atacaaaatt aatacctgat tcatgtagga      480

gaattaaaca ggcctttcaa ggagctgtgc aaaaggaatt acaacatatc gttggatcac      540

agcacatcag agcagagaaa gcgatggtgg atggctcatg gttagatctg gccaagagga      600

gcaagcttga agctcagcct tttgctcatc tcactattaa tgccaccgac atcccatctg      660

gttcccataa agtgagtctg tcctcttggt accatgatcg gggttgggcc aagatctcca      720

acatgacttt tagcaatgga aaactaatag ttaatcagga tggcttttat tacctgtatg      780

ccaacatttg ctttcgacat catgaaactt caggagacct agctacagag tatcttcaac      840

taatggtgta cgtcactaaa accagcatca aaatcccaag ttctcatacc ctgatgaaag      900

gaggaagcac caagtattgg tcagggaatt ctgaattcca tttttattcc ataaacgttg      960

gtggattttt taagttacgg tctggagagg aaatcagcat cgaggtctcc aacccctcct     1020

tactggatcc ggatcaggat gcaacatact ttggggcttt taaagttcga gatatagatt     1080

gagccccagt ttttggagtg ttatgtattt cctggatgtt tggaaacatt ttttaaaaca     1140

agccaagaaa gatgtatata ggtgtgtgag actactaaga ggcatggccc caacggtaca     1200

cgactcagta tccatgctct tgaccttgta gagaacacgc gtatttacct gccagtggga     1260

gatgttagac tcatggtgtg ttacacaatg gtttttaaat tttgtaatga attcctagaa     1320

ttaaaccaga ttggagcaat tacgggttga ccttatgaga aactgcatgt gggctatggg     1380

aggggttggt ccctggtcat gtgccccttc gcagctgaag tggagagggt gtcatctagc     1440

gcaattgaag gatcatctga aggggcaaat tcttttgaat tgttacatca tgctggaacc     1500

tgcaaaaaat actttttcta atgaggagag aaaatatatg tatttttata taatatctaa     1560

agttatattt cagatgtaat gttttctttg caaagtattg taaattatat ttgtgctata     1620

acagacatat ttaactggtg cactttgtaa attccctggg gaaaacttgc agctaaggag     1680

gggaaaaaaa tgttgtttcc taatatcaaa tgcagtatat ttcttcgttc tttttaagtt     1740

aatagatttt ttcagacttg tcaagcctgt gcaaaaaaat taaaatggat gccttgaata     1800

ataagcagga tgttggccac caggtgcctt tcaaatttag aaactaattg actttagaaa     1860

gctgacattg ccaaaaagga tacataatgg gccactgaaa tttgtcaaga gtagttatat     1920

aattgttgaa caggtgtttt tccacaagtg ccgcaaattg tacctttttt tttttttcaa     1980

aatagaaaag ttattagtgg tttatcagca aaaaagtcca attttaattt agtaaatgtt     2040

attttatact gtacaataaa aacattgcct ttgaatgtta attttttggt acaaaaataa     2100

atttatatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2141


<210>  12
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  13
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  14
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  15
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Cys or Ser

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is Glu or Gly

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa is Ser or Gly

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa is Ser or Asn

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa is Leu or Phe

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa is Lys or Gln

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa is Thr or Ile

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa is Asp or Asn

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa is Arg, Thr, or Lys

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa is Ser, Arg, or Pro

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa is Tyr, Cys, or Ser

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is Gly or Cys

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa is absent or Asp

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is absent or Lys

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa is absent or Thr

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Pro, Val or His

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa is Pro, Glu, or Thr

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa is Ser or Pro

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is Glu or Pro

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Phe, Val, or Leu

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa is Leu or Ala

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa is absent or Gly

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  Xaa is Gln or His

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa is Gln or Lys

<220>
<221>  misc_feature
<222>  (179)..(179)
<223>  Xaa is Phe or Tyr

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  Xaa is Tyr or Phe

<220>
<221>  misc_feature
<222>  (192)..(192)
<223>  Xaa is Leu or Val

<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa is Gly or Ala

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  Xaa is Ser or Ala

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa is Ser or Pro

<220>
<221>  misc_feature
<222>  (222)..(222)
<223>  Xaa is Ala or Thr

<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa is Gln or Arg

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  Xaa is Glu or Asp

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa is Met or Leu

<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  Xaa is Val or Met

<220>
<221>  misc_feature
<222>  (292)..(292)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  Xaa is Glu or Gln

<220>
<221>  misc_feature
<222>  (328)..(328)
<223>  Xaa is Leu or Pro

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Xaa Ser Xaa 
1               5                   10                  15      


Ser Thr Ser Xaa Xaa Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Xaa Xaa Gly Thr Xaa Thr 
65                  70                  75                  80  


Tyr Xaa Cys Asn Val Xaa His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Xaa Val Glu Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Pro Xaa Cys 
            100                 105                 110         


Pro Ala Pro Xaa Xaa Xaa Gly Xaa Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Xaa Glu Asp Pro Glu Val Xaa Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Xaa Asn Ser Thr Xaa Arg Val Val Ser Val Leu Thr Val Xaa 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Xaa Leu Pro Xaa Xaa Ile Glu Lys Thr Ile Ser Lys Xaa Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Xaa Xaa Glu 
225                 230                 235                 240 


Xaa Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Xaa Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Xaa Leu Thr Val Asp Lys Ser Arg Trp Gln Xaa Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Xaa Gly Lys 
                325                 330 


<210>  16
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IgG2 Constant HC

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  17
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IgG1 constant HC

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  18
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IgG4 constant HC

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  19
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  variable LC

<400>  19
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  20
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  variable HC

<400>  20
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attactggga gtggtggtag tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcca      300

gggactacgg tgattatgag ttggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  21
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  full length LC

<400>  21
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      705


<210>  22
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  full length HC

<400>  22
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgtgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcaggtatt actgggagtg gtggtagtac atactacgca      240

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agatccaggg      360

actacggtga ttatgagttg gttcgacccc tggggccagg gaaccctggt caccgtctcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      720

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      960

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa a                                               1401


<210>  23
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  mature LC

<400>  23
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gagtgttcgc ggcaggtact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgtt ttactgtcag cagtatggta gttcacctcg gacgttcggc      300

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  24
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  mature HC

<400>  24
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attactggga gtggtggtag tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcca      300

gggactacgg tgattatgag ttggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcaa cttcggcacc      600

cagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt      660

gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg      900

ttccgtgtgg tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  signal peptide of full length LC of SEQ 3

<400>  25

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  signal peptide of full length HC of SEQ 4

<400>  26

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


