                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Keasling, Jay D.
       d'Espaux, Leo
       Wong, Jeff
       Luo, Xiaozhou
       Reiter, Michael
       Denby, Charles
       Lechner, Anna
 
<120>  MICROORGANISMS AND METHODS FOR PRODUCING CANNABINOIDS AND 
       CANNABINOID DERIVATIVES

<130>  DEMT-001/00WO 326934-2003

<150>  US 62/569,532
<151>  2017-10-07

<150>  US 62/491,114
<151>  2017-04-27

<160>  225   

<170>  PatentIn version 3.5

<210>  1
<211>  776
<212>  PRT
<213>  Cannabis sativa

<400>  1

Met Ala Leu Glu Leu Pro His Leu Leu Pro Tyr Lys Leu Val Lys Gly 
1               5                   10                  15      


Gln Thr Leu Val Ala Gln Ala Ala Arg Ala Glu Leu Ala Ser Ser Ser 
            20                  25                  30          


Ser Ser Ser Val Ile Leu Lys Ser Asn Phe Ile Asn Asn Asn Tyr Ile 
        35                  40                  45              


Asn Tyr Cys Asn Asn Asn Asn Asn Asn Glu Arg Arg Leu Val Val Arg 
    50                  55                  60                  


Arg Asp Trp Glu Thr Met Ala Ser Ser Pro Ser His Ser Arg Asn Asn 
65                  70                  75                  80  


Asn Asp Ile Arg Thr Ile Asn His Leu Arg His Val Asp Ser Met Ala 
                85                  90                  95      


Thr Met Pro Ser Gly Ala Gly Lys Ile Pro Arg Leu Asn Ala Val Ile 
            100                 105                 110         


Leu Gly Glu Ala Leu Ala Thr Glu Glu Asn Asp Leu Val Phe Pro Thr 
        115                 120                 125             


Asp Glu Phe Ser Gln Gln Ala His Val Pro Ser Pro Gln Lys Tyr Leu 
    130                 135                 140                 


Glu Met Tyr Lys Arg Ser Ile Glu Asp Pro Ala Gly Phe Trp Ser Glu 
145                 150                 155                 160 


Ile Ala Ser Gln Phe Tyr Trp Lys Gln Lys Trp Asp Asp Ser Val Tyr 
                165                 170                 175     


Ser Glu Asn Leu Asp Val Ser Lys Gly Arg Val Asn Ile Glu Trp Phe 
            180                 185                 190         


Lys Gly Gly Ile Thr Asn Ile Cys Tyr Asn Cys Leu Asp Lys Asn Val 
        195                 200                 205             


Glu Ala Gly Leu Gly Asp Lys Ile Ala Leu Tyr Trp Glu Gly Asn Asp 
    210                 215                 220                 


Thr Gly Phe Asp Asp Ser Leu Thr Tyr Ser Gln Leu Leu His Lys Val 
225                 230                 235                 240 


Cys Gln Leu Ala Asn Tyr Leu Lys Asp Met Gly Val Gln Lys Gly Asp 
                245                 250                 255     


Ala Val Val Ile Tyr Leu Pro Met Leu Leu Glu Leu Pro Ile Thr Met 
            260                 265                 270         


Leu Ala Cys Ala Arg Ile Gly Ala Val His Ser Val Val Phe Ala Gly 
        275                 280                 285             


Phe Ser Ala Glu Ser Leu Ser Gln Arg Ile Ile Asp Cys Lys Pro Lys 
    290                 295                 300                 


Val Val Ile Thr Cys Asn Ala Val Lys Arg Gly Pro Lys Ile Ile His 
305                 310                 315                 320 


Leu Lys Asp Ile Val Asp Ala Ala Leu Val Glu Ser Ala Lys Thr Gly 
                325                 330                 335     


Val Pro Ile Asp Thr Cys Leu Val Tyr Glu Asn Gln Leu Ala Met Lys 
            340                 345                 350         


Arg Asp Ile Thr Lys Trp Gln Asp Gly Arg Asp Ile Trp Trp Gln Asp 
        355                 360                 365             


Val Ile Pro Lys Tyr Pro Thr Glu Cys Ala Val Glu Trp Val Asp Ala 
    370                 375                 380                 


Glu Asp Pro Leu Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro 
385                 390                 395                 400 


Lys Gly Val Leu His Thr Thr Gly Gly Tyr Met Val Tyr Thr Ala Thr 
                405                 410                 415     


Thr Phe Lys Tyr Ala Phe Asp Tyr Lys Pro Ser Asp Val Tyr Trp Cys 
            420                 425                 430         


Thr Ala Asp Cys Gly Trp Ile Thr Gly His Ser Tyr Val Thr Tyr Gly 
        435                 440                 445             


Pro Leu Leu Asn Gly Ala Ser Cys Ile Val Phe Glu Gly Ala Pro Asn 
    450                 455                 460                 


Tyr Pro Asp Ser Gly Arg Cys Trp Asp Ile Val Asp Lys Tyr Lys Val 
465                 470                 475                 480 


Thr Ile Phe Tyr Thr Ala Pro Thr Leu Val Arg Ser Leu Met Arg Asp 
                485                 490                 495     


Gly Asp Glu Tyr Val Thr Arg Tyr Ser Arg Lys Ser Leu Arg Ile Leu 
            500                 505                 510         


Gly Ser Val Gly Glu Pro Ile Asn Pro Ser Ala Trp Arg Trp Phe Tyr 
        515                 520                 525             


Asn Val Val Gly Asp Ser Arg Cys Pro Ile Ser Asp Thr Trp Trp Gln 
    530                 535                 540                 


Thr Glu Thr Gly Gly Phe Met Ile Thr Pro Leu Pro Gly Ala Trp Pro 
545                 550                 555                 560 


Gln Lys Pro Gly Ser Ala Thr Phe Pro Phe Phe Gly Val Lys Pro Val 
                565                 570                 575     


Ile Val Asp Glu Lys Gly Val Glu Ile Glu Gly Glu Cys Ser Gly Tyr 
            580                 585                 590         


Leu Cys Val Lys Gly Ser Trp Pro Gly Ala Phe Arg Thr Leu Tyr Gly 
        595                 600                 605             


Asp Tyr Glu Arg Tyr Glu Thr Thr Tyr Phe Lys Pro Phe Thr Gly Tyr 
    610                 615                 620                 


Tyr Phe Thr Gly Asp Gly Cys Ser Arg Asp Lys Asp Gly Tyr His Trp 
625                 630                 635                 640 


Leu Thr Gly Arg Val Asp Asp Val Ile Asn Val Ser Gly His Arg Ile 
                645                 650                 655     


Gly Thr Ala Glu Val Glu Ser Ala Leu Val Ser His Pro Lys Cys Ala 
            660                 665                 670         


Glu Ala Ala Val Val Gly Ile Glu His Glu Val Lys Gly Gln Ala Ile 
        675                 680                 685             


Tyr Ala Phe Val Thr Leu Val Glu Gly Glu Pro Tyr Ser Glu Glu Leu 
    690                 695                 700                 


Arg Lys Ser Leu Ile Leu Ser Val Arg Lys Gln Ile Gly Ala Phe Ala 
705                 710                 715                 720 


Ala Pro Glu Arg Ile His Trp Ala Pro Gly Leu Pro Lys Thr Arg Ser 
                725                 730                 735     


Gly Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Ala Ser Gly Gln Leu 
            740                 745                 750         


Asp Glu Leu Gly Asp Thr Ser Thr Leu Ala Asp Pro Asn Val Val Glu 
        755                 760                 765             


Gln Leu Ile Ser Leu Ser Asn Cys 
    770                 775     


<210>  2
<211>  579
<212>  PRT
<213>  Streptomyces sp.

<400>  2

Met Glu Leu Ala Leu Pro Ala Glu Leu Ala Pro Thr Leu Pro Glu Ala 
1               5                   10                  15      


Leu Arg Leu Arg Ser Glu Gln Gln Pro Asp Thr Val Ala Tyr Val Phe 
            20                  25                  30          


Leu Arg Asp Gly Glu Thr Pro Glu Glu Thr Leu Thr Tyr Gly Arg Leu 
        35                  40                  45              


Asp Arg Ala Ala Arg Ala Arg Ala Ala Ala Leu Glu Ala Ala Gly Leu 
    50                  55                  60                  


Ala Gly Gly Thr Ala Val Leu Leu Tyr Pro Ser Gly Leu Glu Phe Val 
65                  70                  75                  80  


Ala Ala Leu Leu Gly Cys Met Tyr Ala Gly Thr Ala Gly Ala Pro Val 
                85                  90                  95      


Gln Val Pro Thr Arg Arg Arg Gly Met Glu Arg Ala Arg Arg Ile Ala 
            100                 105                 110         


Asp Asp Ala Gly Ala Lys Thr Ile Leu Thr Thr Thr Ala Val Lys Arg 
        115                 120                 125             


Glu Val Glu Glu His Phe Ala Asp Leu Leu Thr Gly Leu Thr Val Ile 
    130                 135                 140                 


Asp Thr Glu Ser Leu Pro Asp Val Pro Asp Asp Ala Pro Ala Val Arg 
145                 150                 155                 160 


Leu Pro Gly Pro Asp Asp Val Ala Leu Leu Gln Tyr Thr Ser Gly Ser 
                165                 170                 175     


Thr Gly Asp Pro Lys Gly Val Glu Val Thr His Ala Asn Phe Arg Ala 
            180                 185                 190         


Asn Val Ala Glu Thr Val Glu Leu Trp Pro Val Arg Ser Asp Gly Thr 
        195                 200                 205             


Val Val Asn Trp Leu Pro Leu Phe His Asp Met Gly Leu Met Phe Gly 
    210                 215                 220                 


Val Val Met Pro Leu Phe Thr Gly Val Pro Ala Tyr Leu Met Ala Pro 
225                 230                 235                 240 


Gln Ser Phe Ile Arg Arg Pro Ala Arg Trp Leu Glu Ala Ile Ser Arg 
                245                 250                 255     


Phe Arg Gly Thr His Ala Ala Ala Pro Ser Phe Ala Tyr Glu Leu Cys 
            260                 265                 270         


Val Arg Ser Val Ala Asp Thr Gly Leu Pro Ala Gly Leu Asp Leu Ser 
        275                 280                 285             


Ser Trp Arg Val Ala Val Asn Gly Ala Glu Pro Val Arg Trp Thr Ala 
    290                 295                 300                 


Val Ala Asp Phe Thr Glu Ala Tyr Ala Pro Ala Gly Phe Arg Pro Gln 
305                 310                 315                 320 


Ala Met Cys Pro Gly Tyr Gly Leu Ala Glu Asn Thr Leu Lys Leu Ser 
                325                 330                 335     


Gly Ser Pro Glu Asp Arg Pro Pro Thr Leu Leu Arg Ala Asp Ala Ala 
            340                 345                 350         


Ala Leu Gln Asp Gly Arg Val Val Pro Leu Thr Gly Pro Gly Thr Asp 
        355                 360                 365             


Gly Val Arg Leu Val Gly Ser Gly Val Thr Val Pro Ser Ser Arg Val 
    370                 375                 380                 


Ala Val Val Asp Pro Gly Thr Gly Thr Glu Gln Pro Ala Gly Arg Val 
385                 390                 395                 400 


Gly Glu Ile Trp Ile Asn Gly Pro Cys Val Ala Arg Gly Tyr His Gly 
                405                 410                 415     


Arg Pro Ala Glu Ser Ala Glu Ser Phe Gly Ala Arg Ile Ala Gly Gln 
            420                 425                 430         


Glu Ala Arg Gly Thr Trp Leu Arg Thr Gly Asp Leu Gly Phe Leu His 
        435                 440                 445             


Asp Gly Glu Val Phe Val Ala Gly Arg Leu Lys Asp Val Val Ile His 
    450                 455                 460                 


Gln Gly Arg Asn Phe Tyr Pro Gln Asp Ile Glu Leu Ser Ala Glu Val 
465                 470                 475                 480 


Ser Asp Arg Ala Leu His Pro Asn Cys Ala Ala Ala Phe Ala Leu Asp 
                485                 490                 495     


Asp Gly Arg Thr Glu Arg Leu Val Leu Leu Val Glu Ala Asp Gly Arg 
            500                 505                 510         


Ala Leu Arg Asn Gly Gly Ala Asp Ala Leu Arg Ala Arg Val His Asp 
        515                 520                 525             


Ala Val Trp Asp Arg Gln Arg Leu Arg Ile Asp Glu Ile Val Leu Leu 
    530                 535                 540                 


Arg Arg Gly Ala Leu Pro Lys Thr Ser Ser Gly Lys Val Gln Arg Arg 
545                 550                 555                 560 


Leu Ala Arg Ser Arg Tyr Leu Asp Gly Glu Phe Gly Pro Ala Pro Ala 
                565                 570                 575     


Arg Glu Ala 
            


<210>  3
<211>  1671
<212>  PRT
<213>  Aspergillus sp.

<400>  3

Met Val Ile Gln Gly Lys Arg Leu Ala Ala Ser Ser Ile Gln Leu Leu 
1               5                   10                  15      


Ala Ser Ser Leu Asp Ala Lys Lys Leu Cys Tyr Glu Tyr Asp Glu Arg 
            20                  25                  30          


Gln Ala Pro Gly Val Thr Gln Ile Thr Glu Glu Ala Pro Thr Glu Gln 
        35                  40                  45              


Pro Pro Leu Ser Thr Pro Pro Ser Leu Pro Gln Thr Pro Asn Ile Ser 
    50                  55                  60                  


Pro Ile Ser Ala Ser Lys Ile Val Ile Asp Asp Val Ala Leu Ser Arg 
65                  70                  75                  80  


Val Gln Ile Val Gln Ala Leu Val Ala Arg Lys Leu Lys Thr Ala Ile 
                85                  90                  95      


Ala Gln Leu Pro Thr Ser Lys Ser Ile Lys Glu Leu Ser Gly Gly Arg 
            100                 105                 110         


Ser Ser Leu Gln Asn Glu Leu Val Gly Asp Ile His Asn Glu Phe Ser 
        115                 120                 125             


Ser Ile Pro Asp Ala Pro Glu Gln Ile Leu Leu Arg Asp Phe Gly Asp 
    130                 135                 140                 


Ala Asn Pro Thr Val Gln Leu Gly Lys Thr Ser Ser Ala Ala Val Ala 
145                 150                 155                 160 


Lys Leu Ile Ser Ser Lys Met Pro Ser Asp Phe Asn Ala Asn Ala Ile 
                165                 170                 175     


Arg Ala His Leu Ala Asn Lys Trp Gly Leu Gly Pro Leu Arg Gln Thr 
            180                 185                 190         


Ala Val Leu Leu Tyr Ala Ile Ala Ser Glu Pro Pro Ser Arg Leu Ala 
        195                 200                 205             


Ser Ser Ser Ala Ala Glu Glu Tyr Trp Asp Asn Val Ser Ser Met Tyr 
    210                 215                 220                 


Ala Glu Ser Cys Gly Ile Thr Leu Arg Pro Arg Gln Asp Thr Met Asn 
225                 230                 235                 240 


Glu Asp Ala Met Ala Ser Ser Ala Ile Asp Pro Ala Val Val Ala Glu 
                245                 250                 255     


Phe Ser Lys Gly His Arg Arg Leu Gly Val Gln Gln Phe Gln Ala Leu 
            260                 265                 270         


Ala Glu Tyr Leu Gln Ile Asp Leu Ser Gly Ser Gln Ala Ser Gln Ser 
        275                 280                 285             


Asp Ala Leu Val Ala Glu Leu Gln Gln Lys Val Asp Leu Trp Thr Ala 
    290                 295                 300                 


Glu Met Thr Pro Glu Phe Leu Ala Gly Ile Ser Pro Met Leu Asp Val 
305                 310                 315                 320 


Lys Lys Ser Arg Arg Tyr Gly Ser Trp Trp Asn Met Ala Arg Gln Asp 
                325                 330                 335     


Val Leu Ala Phe Tyr Arg Arg Pro Ser Tyr Ser Glu Phe Val Asp Asp 
            340                 345                 350         


Ala Leu Ala Phe Lys Val Phe Leu Asn Arg Leu Cys Asn Arg Ala Asp 
        355                 360                 365             


Glu Ala Leu Leu Asn Met Val Arg Ser Leu Ser Cys Asp Ala Tyr Phe 
    370                 375                 380                 


Lys Gln Gly Ser Leu Pro Gly Tyr His Ala Ala Ser Arg Leu Leu Glu 
385                 390                 395                 400 


Gln Ala Ile Thr Ser Thr Val Ala Asp Cys Pro Lys Ala Arg Leu Ile 
                405                 410                 415     


Leu Pro Ala Val Gly Pro His Thr Thr Ile Thr Lys Asp Gly Thr Ile 
            420                 425                 430         


Glu Tyr Ala Glu Ala Pro Arg Gln Gly Val Ser Gly Pro Thr Ala Tyr 
        435                 440                 445             


Ile Gln Ser Leu Arg Gln Gly Ala Ser Phe Ile Gly Leu Lys Ser Ala 
    450                 455                 460                 


Asp Val Asp Thr Gln Ser Asn Leu Thr Asp Ala Leu Leu Asp Ala Met 
465                 470                 475                 480 


Cys Leu Ala Leu His Asn Gly Ile Ser Phe Val Gly Lys Thr Phe Leu 
                485                 490                 495     


Val Thr Gly Ala Gly Gln Gly Ser Ile Gly Ala Gly Val Val Arg Leu 
            500                 505                 510         


Leu Leu Glu Gly Gly Ala Arg Val Leu Val Thr Thr Ser Arg Glu Pro 
        515                 520                 525             


Ala Thr Thr Ser Arg Tyr Phe Gln Gln Met Tyr Asp Asn His Gly Ala 
    530                 535                 540                 


Lys Phe Ser Glu Leu Arg Val Val Pro Cys Asn Leu Ala Ser Ala Gln 
545                 550                 555                 560 


Asp Cys Glu Gly Leu Ile Arg His Val Tyr Asp Pro Arg Gly Leu Asn 
                565                 570                 575     


Trp Asp Leu Asp Ala Ile Leu Pro Phe Ala Ala Ala Ser Asp Tyr Ser 
            580                 585                 590         


Thr Glu Met His Asp Ile Arg Gly Gln Ser Glu Leu Gly His Arg Leu 
        595                 600                 605             


Met Leu Val Asn Val Phe Arg Val Leu Gly His Ile Val His Cys Lys 
    610                 615                 620                 


Arg Asp Ala Gly Val Asp Cys His Pro Thr Gln Val Leu Leu Pro Leu 
625                 630                 635                 640 


Ser Pro Asn His Gly Ile Phe Gly Gly Asp Gly Met Tyr Pro Glu Ser 
                645                 650                 655     


Lys Leu Ala Leu Glu Ser Leu Phe His Arg Ile Arg Ser Glu Ser Trp 
            660                 665                 670         


Ser Asp Gln Leu Ser Ile Cys Gly Val Arg Ile Gly Trp Thr Arg Ser 
        675                 680                 685             


Thr Gly Leu Met Thr Ala His Asp Ile Ile Ala Glu Thr Val Glu Glu 
    690                 695                 700                 


His Gly Ile Arg Thr Phe Ser Val Ala Glu Met Ala Leu Asn Ile Ala 
705                 710                 715                 720 


Met Leu Leu Thr Pro Asp Phe Val Ala His Cys Glu Asp Gly Pro Leu 
                725                 730                 735     


Asp Ala Asp Phe Thr Gly Ser Leu Gly Thr Leu Gly Ser Ile Pro Gly 
            740                 745                 750         


Phe Leu Ala Gln Leu His Gln Lys Val Gln Leu Ala Ala Glu Val Ile 
        755                 760                 765             


Arg Ala Val Gln Ala Glu Asp Glu His Glu Arg Phe Leu Ser Pro Gly 
    770                 775                 780                 


Thr Lys Pro Thr Leu Gln Ala Pro Val Ala Pro Met His Pro Arg Ser 
785                 790                 795                 800 


Ser Leu Arg Val Gly Tyr Pro Arg Leu Pro Asp Tyr Glu Gln Glu Ile 
                805                 810                 815     


Arg Pro Leu Ser Pro Arg Leu Glu Arg Leu Gln Asp Pro Ala Asn Ala 
            820                 825                 830         


Val Val Val Val Gly Tyr Ser Glu Leu Gly Pro Trp Gly Ser Ala Arg 
        835                 840                 845             


Leu Arg Trp Glu Ile Glu Ser Gln Gly Gln Trp Thr Ser Ala Gly Tyr 
    850                 855                 860                 


Val Glu Leu Ala Trp Leu Met Asn Leu Ile Arg His Val Asn Asp Glu 
865                 870                 875                 880 


Ser Tyr Val Gly Trp Val Asp Thr Gln Thr Gly Lys Pro Val Arg Asp 
                885                 890                 895     


Gly Glu Ile Gln Ala Leu Tyr Gly Asp His Ile Asp Asn His Thr Gly 
            900                 905                 910         


Ile Arg Pro Ile Gln Ser Thr Ser Tyr Asn Pro Glu Arg Met Glu Val 
        915                 920                 925             


Leu Gln Glu Val Ala Val Glu Glu Asp Leu Pro Glu Phe Glu Val Ser 
    930                 935                 940                 


Gln Leu Thr Ala Asp Ala Met Arg Leu Arg His Gly Ala Asn Val Ser 
945                 950                 955                 960 


Ile Arg Pro Ser Gly Asn Pro Asp Ala Cys His Val Lys Leu Lys Arg 
                965                 970                 975     


Gly Ala Val Ile Leu Val Pro Lys Thr Val Pro Phe Val Trp Gly Ser 
            980                 985                 990         


Cys Ala Gly Glu Leu Pro Lys Gly  Trp Thr Pro Ala Lys  Tyr Gly Ile 
        995                 1000                 1005             


Pro Glu  Asn Leu Ile His Gln  Val Asp Pro Val Thr  Leu Tyr Thr 
    1010                 1015                 1020             


Ile Cys  Cys Val Ala Glu Ala  Phe Tyr Ser Ala Gly  Ile Thr His 
    1025                 1030                 1035             


Pro Leu  Glu Val Phe Arg His  Ile His Leu Ser Glu  Leu Gly Asn 
    1040                 1045                 1050             


Phe Ile  Gly Ser Ser Met Gly  Gly Pro Thr Lys Thr  Arg Gln Leu 
    1055                 1060                 1065             


Tyr Arg  Asp Val Tyr Phe Asp  His Glu Ile Pro Ser  Asp Val Leu 
    1070                 1075                 1080             


Gln Asp  Thr Tyr Leu Asn Thr  Pro Ala Ala Trp Val  Asn Met Leu 
    1085                 1090                 1095             


Leu Leu  Gly Cys Thr Gly Pro  Ile Lys Thr Pro Val  Gly Ala Cys 
    1100                 1105                 1110             


Ala Thr  Gly Val Glu Ser Ile  Asp Ser Gly Tyr Glu  Ser Ile Met 
    1115                 1120                 1125             


Ala Gly  Lys Thr Lys Met Cys  Leu Val Gly Gly Tyr  Asp Asp Leu 
    1130                 1135                 1140             


Gln Glu  Glu Ala Ser Tyr Gly  Phe Ala Gln Leu Lys  Ala Thr Val 
    1145                 1150                 1155             


Asn Val  Glu Glu Glu Ile Ala  Cys Gly Arg Gln Pro  Ser Glu Met 
    1160                 1165                 1170             


Ser Arg  Pro Met Ala Glu Ser  Arg Ala Gly Phe Val  Glu Ala His 
    1175                 1180                 1185             


Gly Cys  Gly Val Gln Leu Leu  Cys Arg Gly Asp Ile  Ala Leu Gln 
    1190                 1195                 1200             


Met Gly  Leu Pro Ile Tyr Ala  Val Ile Ala Ser Ser  Ala Met Ala 
    1205                 1210                 1215             


Ala Asp  Lys Ile Gly Ser Ser  Val Pro Ala Pro Gly  Gln Gly Ile 
    1220                 1225                 1230             


Leu Ser  Phe Ser Arg Glu Arg  Ala Arg Ser Ser Met  Ile Ser Val 
    1235                 1240                 1245             


Thr Ser  Arg Pro Ser Ser Arg  Ser Ser Thr Ser Ser  Glu Val Ser 
    1250                 1255                 1260             


Asp Lys  Ser Ser Leu Thr Ser  Ile Thr Ser Ile Ser  Asn Pro Ala 
    1265                 1270                 1275             


Pro Arg  Ala Gln Arg Ala Arg  Ser Thr Thr Asp Met  Ala Pro Leu 
    1280                 1285                 1290             


Arg Ala  Ala Leu Ala Thr Trp  Gly Leu Thr Ile Asp  Asp Leu Asp 
    1295                 1300                 1305             


Val Ala  Ser Leu His Gly Thr  Ser Thr Arg Gly Asn  Asp Leu Asn 
    1310                 1315                 1320             


Glu Pro  Glu Val Ile Glu Thr  Gln Met Arg His Leu  Gly Arg Thr 
    1325                 1330                 1335             


Pro Gly  Arg Pro Leu Trp Ala  Ile Cys Gln Lys Ser  Val Thr Gly 
    1340                 1345                 1350             


His Pro  Lys Ala Pro Ala Ala  Ala Trp Met Leu Asn  Gly Cys Leu 
    1355                 1360                 1365             


Gln Val  Leu Asp Ser Gly Leu  Val Pro Gly Asn Arg  Asn Leu Asp 
    1370                 1375                 1380             


Thr Leu  Asp Glu Ala Leu Arg  Ser Ala Ser His Leu  Cys Phe Pro 
    1385                 1390                 1395             


Thr Arg  Thr Val Gln Leu Arg  Glu Val Lys Ala Phe  Leu Leu Thr 
    1400                 1405                 1410             


Ser Phe  Gly Phe Gly Gln Lys  Gly Gly Gln Val Val  Gly Val Ala 
    1415                 1420                 1425             


Pro Lys  Tyr Phe Phe Ala Thr  Leu Pro Arg Pro Glu  Val Glu Gly 
    1430                 1435                 1440             


Tyr Tyr  Arg Lys Val Arg Val  Arg Thr Glu Ala Gly  Asp Arg Ala 
    1445                 1450                 1455             


Tyr Ala  Ala Ala Val Met Ser  Gln Ala Val Val Lys  Ile Gln Thr 
    1460                 1465                 1470             


Gln Asn  Pro Tyr Asp Glu Pro  Asp Ala Pro Arg Ile  Phe Leu Asp 
    1475                 1480                 1485             


Pro Leu  Ala Arg Ile Ser Gln  Asp Pro Ser Thr Gly  Gln Tyr Arg 
    1490                 1495                 1500             


Phe Arg  Ser Asp Ala Thr Pro  Ala Leu Asp Asp Asp  Ala Leu Pro 
    1505                 1510                 1515             


Pro Pro  Gly Glu Pro Thr Glu  Leu Val Lys Gly Ile  Ser Ser Ala 
    1520                 1525                 1530             


Trp Ile  Glu Glu Lys Val Arg  Pro His Met Ser Pro  Gly Gly Thr 
    1535                 1540                 1545             


Val Gly  Val Asp Leu Val Pro  Leu Ala Ser Phe Asp  Ala Tyr Lys 
    1550                 1555                 1560             


Asn Ala  Ile Phe Val Glu Arg  Asn Tyr Thr Val Arg  Glu Arg Asp 
    1565                 1570                 1575             


Trp Ala  Glu Lys Ser Ala Asp  Val Arg Ala Ala Tyr  Ala Ser Arg 
    1580                 1585                 1590             


Trp Cys  Ala Lys Glu Ala Val  Phe Lys Cys Leu Gln  Thr His Ser 
    1595                 1600                 1605             


Gln Gly  Ala Gly Ala Ala Met  Lys Glu Ile Glu Ile  Glu His Gly 
    1610                 1615                 1620             


Gly Asn  Gly Ala Pro Lys Val  Lys Leu Arg Gly Ala  Ala Gln Thr 
    1625                 1630                 1635             


Ala Ala  Arg Gln Arg Gly Leu  Glu Gly Val Gln Leu  Ser Ile Ser 
    1640                 1645                 1650             


Tyr Gly  Asp Asp Ala Val Ile  Ala Val Ala Leu Gly  Leu Met Ser 
    1655                 1660                 1665             


Gly Ala  Ser 
    1670     


<210>  4
<211>  1888
<212>  PRT
<213>  Aspergillus sp.

<400>  4

Met Gly Ser Val Ser Arg Glu His Glu Ser Ile Pro Ile Gln Ala Ala 
1               5                   10                  15      


Gln Arg Gly Ala Ala Arg Ile Cys Ala Ala Phe Gly Gly Gln Gly Ser 
            20                  25                  30          


Asn Asn Leu Asp Val Leu Lys Gly Leu Leu Glu Leu Tyr Lys Arg Tyr 
        35                  40                  45              


Gly Pro Asp Leu Asp Glu Leu Leu Asp Val Ala Ser Asn Thr Leu Ser 
    50                  55                  60                  


Gln Leu Ala Ser Ser Pro Ala Ala Ile Asp Val His Glu Pro Trp Gly 
65                  70                  75                  80  


Phe Asp Leu Arg Gln Trp Leu Thr Thr Pro Glu Val Ala Pro Ser Lys 
                85                  90                  95      


Glu Ile Leu Ala Leu Pro Pro Arg Ser Phe Pro Leu Asn Thr Leu Leu 
            100                 105                 110         


Ser Leu Ala Leu Tyr Cys Ala Thr Cys Arg Glu Leu Glu Leu Asp Pro 
        115                 120                 125             


Gly Gln Phe Arg Ser Leu Leu His Ser Ser Thr Gly His Ser Gln Gly 
    130                 135                 140                 


Ile Leu Ala Ala Val Ala Ile Thr Gln Ala Glu Ser Trp Pro Thr Phe 
145                 150                 155                 160 


Tyr Asp Ala Cys Arg Thr Val Leu Gln Ile Ser Phe Trp Ile Gly Leu 
                165                 170                 175     


Glu Ala Tyr Leu Phe Thr Pro Ser Ser Ala Ala Ser Asp Ala Met Ile 
            180                 185                 190         


Gln Asp Cys Ile Glu His Gly Glu Gly Leu Leu Ser Ser Met Leu Ser 
        195                 200                 205             


Val Ser Gly Leu Ser Arg Ser Gln Val Glu Arg Val Ile Glu His Val 
    210                 215                 220                 


Asn Lys Gly Leu Gly Glu Cys Asn Arg Trp Val His Leu Ala Leu Val 
225                 230                 235                 240 


Asn Ser His Glu Lys Phe Val Leu Ala Gly Pro Pro Gln Ser Leu Trp 
                245                 250                 255     


Ala Val Cys Leu His Val Arg Arg Ile Arg Ala Asp Asn Asp Leu Asp 
            260                 265                 270         


Gln Ser Arg Ile Leu Phe Arg Asn Arg Lys Pro Ile Val Asp Ile Leu 
        275                 280                 285             


Phe Leu Pro Ile Ser Ala Pro Phe His Thr Pro Tyr Leu Asp Gly Val 
    290                 295                 300                 


Gln Asp Arg Val Ile Glu Ala Leu Ser Ser Ala Ser Leu Ala Leu His 
305                 310                 315                 320 


Ser Ile Lys Ile Pro Leu Tyr His Thr Gly Thr Gly Ser Asn Leu Gln 
                325                 330                 335     


Glu Leu Gln Pro His Gln Leu Ile Pro Thr Leu Ile Arg Ala Ile Thr 
            340                 345                 350         


Val Asp Gln Leu Asp Trp Pro Leu Val Cys Arg Gly Leu Asn Ala Thr 
        355                 360                 365             


His Val Leu Asp Phe Gly Pro Gly Gln Thr Cys Ser Leu Ile Gln Glu 
    370                 375                 380                 


Leu Thr Gln Gly Thr Gly Val Ser Val Ile Gln Leu Thr Thr Gln Ser 
385                 390                 395                 400 


Gly Pro Lys Pro Val Gly Gly His Leu Ala Ala Val Asn Trp Glu Ala 
                405                 410                 415     


Glu Phe Gly Leu Arg Leu His Ala Asn Val His Gly Ala Ala Lys Leu 
            420                 425                 430         


His Asn Arg Met Thr Thr Leu Leu Gly Lys Pro Pro Val Met Val Ala 
        435                 440                 445             


Gly Met Thr Pro Thr Thr Val Arg Trp Asp Phe Val Ala Ala Val Ala 
    450                 455                 460                 


Gln Ala Gly Tyr His Val Glu Leu Ala Gly Gly Gly Tyr His Ala Glu 
465                 470                 475                 480 


Arg Gln Phe Glu Ala Glu Ile Arg Arg Leu Ala Thr Ala Ile Pro Ala 
                485                 490                 495     


Asp His Gly Ile Thr Cys Asn Leu Leu Tyr Ala Lys Pro Thr Thr Phe 
            500                 505                 510         


Ser Trp Gln Ile Ser Val Ile Lys Asp Leu Val Arg Gln Gly Val Pro 
        515                 520                 525             


Val Glu Gly Ile Thr Ile Gly Ala Gly Ile Pro Ser Pro Glu Val Val 
    530                 535                 540                 


Gln Glu Cys Val Gln Ser Ile Gly Leu Lys His Ile Ser Phe Lys Pro 
545                 550                 555                 560 


Gly Ser Phe Glu Ala Ile His Gln Val Ile Gln Ile Ala Arg Thr His 
                565                 570                 575     


Pro Asn Phe Leu Ile Gly Leu Gln Trp Thr Ala Gly Arg Gly Gly Gly 
            580                 585                 590         


His His Ser Trp Glu Asp Phe His Gly Pro Ile Leu Ala Thr Tyr Ala 
        595                 600                 605             


Gln Ile Arg Ser Cys Pro Asn Ile Leu Leu Val Val Gly Ser Gly Phe 
    610                 615                 620                 


Gly Gly Gly Pro Asp Thr Phe Pro Tyr Leu Thr Gly Gln Trp Ala Gln 
625                 630                 635                 640 


Ala Phe Gly Tyr Pro Cys Met Pro Phe Asp Gly Val Leu Leu Gly Ser 
                645                 650                 655     


Arg Met Met Val Ala Arg Glu Ala His Thr Ser Ala Gln Ala Lys Arg 
            660                 665                 670         


Leu Ile Ile Asp Ala Gln Gly Val Gly Asp Ala Asp Trp His Lys Ser 
        675                 680                 685             


Phe Asp Glu Pro Thr Gly Gly Val Val Thr Val Asn Ser Glu Phe Gly 
    690                 695                 700                 


Gln Pro Ile His Val Leu Ala Thr Arg Gly Val Met Leu Trp Lys Glu 
705                 710                 715                 720 


Leu Asp Asn Arg Val Phe Ser Ile Lys Asp Thr Ser Lys Arg Leu Glu 
                725                 730                 735     


Tyr Leu Arg Asn His Arg Gln Glu Ile Val Ser Arg Leu Asn Ala Asp 
            740                 745                 750         


Phe Ala Arg Pro Trp Phe Ala Val Asp Gly His Gly Gln Asn Val Glu 
        755                 760                 765             


Leu Glu Asp Met Thr Tyr Leu Glu Val Leu Arg Arg Leu Cys Asp Leu 
    770                 775                 780                 


Thr Tyr Val Ser His Gln Lys Arg Trp Val Asp Pro Ser Tyr Arg Ile 
785                 790                 795                 800 


Leu Leu Leu Asp Phe Val His Leu Leu Arg Glu Arg Phe Gln Cys Ala 
                805                 810                 815     


Ile Asp Asn Pro Gly Glu Tyr Pro Leu Asp Ile Ile Val Arg Val Glu 
            820                 825                 830         


Glu Ser Leu Lys Asp Lys Ala Tyr Arg Thr Leu Tyr Pro Glu Asp Val 
        835                 840                 845             


Ser Leu Leu Met His Leu Phe Ser Arg Arg Asp Ile Lys Pro Val Pro 
    850                 855                 860                 


Phe Ile Pro Arg Leu Asp Glu Arg Phe Glu Thr Trp Phe Lys Lys Asp 
865                 870                 875                 880 


Ser Leu Trp Gln Ser Glu Asp Val Glu Ala Val Ile Gly Gln Asp Val 
                885                 890                 895     


Gln Arg Ile Phe Ile Ile Gln Gly Pro Met Ala Val Gln Tyr Ser Ile 
            900                 905                 910         


Ser Asp Asp Glu Ser Val Lys Asp Ile Leu His Asn Ile Cys Asn His 
        915                 920                 925             


Tyr Val Glu Ala Leu Gln Ala Asp Ser Arg Glu Thr Ser Ile Gly Asp 
    930                 935                 940                 


Val His Ser Ile Thr Gln Lys Pro Leu Ser Ala Phe Pro Gly Leu Lys 
945                 950                 955                 960 


Val Thr Thr Asn Arg Val Gln Gly Leu Tyr Lys Phe Glu Lys Val Gly 
                965                 970                 975     


Ala Val Pro Glu Met Asp Val Leu Phe Glu His Ile Val Gly Leu Ser 
            980                 985                 990         


Lys Ser Trp Ala Arg Thr Cys Leu  Met Ser Lys Ser Val  Phe Arg Asp 
        995                 1000                 1005             


Gly Ser  Arg Leu His Asn Pro  Ile Arg Ala Ala Leu  Gln Leu Gln 
    1010                 1015                 1020             


Arg Gly  Asp Thr Ile Glu Val  Leu Leu Thr Ala Asp  Ser Glu Ile 
    1025                 1030                 1035             


Arg Lys  Ile Arg Leu Ile Ser  Pro Thr Gly Asp Gly  Gly Ser Thr 
    1040                 1045                 1050             


Ser Lys  Val Val Leu Glu Ile  Val Ser Asn Asp Gly  Gln Arg Val 
    1055                 1060                 1065             


Phe Ala  Thr Leu Ala Pro Asn  Ile Pro Leu Ser Pro  Glu Pro Ser 
    1070                 1075                 1080             


Val Val  Phe Cys Phe Lys Val  Asp Gln Lys Pro Asn  Glu Trp Thr 
    1085                 1090                 1095             


Leu Glu  Glu Asp Ala Ser Gly  Arg Ala Glu Arg Ile  Lys Ala Leu 
    1100                 1105                 1110             


Tyr Met  Ser Leu Trp Asn Leu  Gly Phe Pro Asn Lys  Ala Ser Val 
    1115                 1120                 1125             


Leu Gly  Leu Asn Ser Gln Phe  Thr Gly Glu Glu Leu  Met Ile Thr 
    1130                 1135                 1140             


Thr Asp  Lys Ile Arg Asp Phe  Glu Arg Val Leu Arg  Gln Thr Ser 
    1145                 1150                 1155             


Pro Leu  Gln Leu Gln Ser Trp  Asn Pro Gln Gly Cys  Val Pro Ile 
    1160                 1165                 1170             


Asp Tyr  Cys Val Val Ile Ala  Trp Ser Ala Leu Thr  Lys Pro Leu 
    1175                 1180                 1185             


Met Val  Ser Ser Leu Lys Cys  Asp Leu Leu Asp Leu  Leu His Ser 
    1190                 1195                 1200             


Ala Ile  Ser Phe His Tyr Ala  Pro Ser Val Lys Pro  Leu Arg Val 
    1205                 1210                 1215             


Gly Asp  Ile Val Lys Thr Ser  Ser Arg Ile Leu Ala  Val Ser Val 
    1220                 1225                 1230             


Arg Pro  Arg Gly Thr Met Leu  Thr Val Ser Ala Asp  Ile Gln Arg 
    1235                 1240                 1245             


Gln Gly  Gln His Val Val Thr  Val Lys Ser Asp Phe  Phe Leu Gly 
    1250                 1255                 1260             


Gly Pro  Val Leu Ala Cys Glu  Thr Pro Phe Glu Leu  Thr Glu Glu 
    1265                 1270                 1275             


Pro Glu  Met Val Val His Val  Asp Ser Glu Val Arg  Arg Ala Ile 
    1280                 1285                 1290             


Leu His  Ser Arg Lys Trp Leu  Met Arg Glu Asp Arg  Ala Leu Asp 
    1295                 1300                 1305             


Leu Leu  Gly Arg Gln Leu Leu  Phe Arg Leu Lys Ser  Glu Lys Leu 
    1310                 1315                 1320             


Phe Arg  Pro Asp Gly Gln Leu  Ala Leu Leu Gln Val  Thr Gly Ser 
    1325                 1330                 1335             


Val Phe  Ser Tyr Ser Pro Asp  Gly Ser Thr Thr Ala  Phe Gly Arg 
    1340                 1345                 1350             


Val Tyr  Phe Glu Ser Glu Ser  Cys Thr Gly Asn Val  Val Met Asp 
    1355                 1360                 1365             


Phe Leu  His Arg Tyr Gly Ala  Pro Arg Ala Gln Leu  Leu Glu Leu 
    1370                 1375                 1380             


Gln His  Pro Gly Trp Thr Gly  Thr Ser Thr Val Ala  Val Arg Gly 
    1385                 1390                 1395             


Pro Arg  Arg Ser Gln Ser Tyr  Ala Arg Val Ser Leu  Asp His Asn 
    1400                 1405                 1410             


Pro Ile  His Val Cys Pro Ala  Phe Ala Arg Tyr Ala  Gly Leu Ser 
    1415                 1420                 1425             


Gly Pro  Ile Val His Gly Met  Glu Thr Ser Ala Met  Met Arg Arg 
    1430                 1435                 1440             


Ile Ala  Glu Trp Ala Ile Gly  Asp Ala Asp Arg Ser  Arg Phe Arg 
    1445                 1450                 1455             


Ser Trp  His Ile Thr Leu Gln  Ala Pro Val His Pro  Asn Asp Pro 
    1460                 1465                 1470             


Leu Arg  Val Glu Leu Gln His  Lys Ala Met Glu Asp  Gly Glu Met 
    1475                 1480                 1485             


Val Leu  Lys Val Gln Ala Phe  Asn Glu Arg Thr Glu  Glu Arg Val 
    1490                 1495                 1500             


Ala Glu  Ala Asp Ala His Val  Glu Gln Glu Thr Thr  Ala Tyr Val 
    1505                 1510                 1515             


Phe Cys  Gly Gln Gly Ser Gln  Arg Gln Gly Met Gly  Met Asp Leu 
    1520                 1525                 1530             


Tyr Val  Asn Cys Pro Glu Ala  Lys Ala Leu Trp Ala  Arg Ala Asp 
    1535                 1540                 1545             


Lys His  Leu Trp Glu Lys Tyr  Gly Phe Ser Ile Leu  His Ile Val 
    1550                 1555                 1560             


Gln Asn  Asn Pro Pro Ala Leu  Thr Val His Phe Gly  Ser Gln Arg 
    1565                 1570                 1575             


Gly Arg  Arg Ile Arg Ala Asn  Tyr Leu Arg Met Met  Gly Gln Pro 
    1580                 1585                 1590             


Pro Ile  Asp Gly Arg His Pro  Pro Ile Leu Lys Gly  Leu Thr Arg 
    1595                 1600                 1605             


Asn Ser  Thr Ser Tyr Thr Phe  Ser Tyr Ser Gln Gly  Leu Leu Met 
    1610                 1615                 1620             


Ser Thr  Gln Phe Ala Gln Pro  Ala Leu Ala Leu Met  Glu Met Ala 
    1625                 1630                 1635             


Gln Phe  Glu Trp Leu Lys Ala  Gln Gly Val Val Gln  Lys Gly Ala 
    1640                 1645                 1650             


Arg Phe  Ala Gly His Ser Leu  Gly Glu Tyr Ala Ala  Leu Gly Ala 
    1655                 1660                 1665             


Cys Ala  Ser Phe Leu Ser Phe  Glu Asp Leu Ile Ser  Leu Ile Phe 
    1670                 1675                 1680             


Tyr Arg  Gly Leu Lys Met Gln  Asn Ala Leu Pro Arg  Asp Ala Asn 
    1685                 1690                 1695             


Gly His  Thr Asp Tyr Gly Met  Leu Ala Ala Asp Pro  Ser Arg Ile 
    1700                 1705                 1710             


Gly Lys  Gly Phe Glu Glu Ala  Ser Leu Lys Cys Leu  Val His Ile 
    1715                 1720                 1725             


Ile Gln  Gln Glu Thr Gly Trp  Phe Val Glu Val Val  Asn Tyr Asn 
    1730                 1735                 1740             


Ile Asn  Ser Gln Gln Tyr Val  Cys Ala Gly His Phe  Arg Ala Leu 
    1745                 1750                 1755             


Trp Met  Leu Gly Lys Ile Cys  Asp Asp Leu Ser Cys  His Pro Gln 
    1760                 1765                 1770             


Pro Glu  Thr Val Glu Gly Gln  Glu Leu Arg Ala Met  Val Trp Lys 
    1775                 1780                 1785             


His Val  Pro Thr Val Glu Gln  Val Pro Arg Glu Asp  Arg Met Glu 
    1790                 1795                 1800             


Arg Gly  Arg Ala Thr Ile Pro  Leu Pro Gly Ile Asp  Ile Pro Tyr 
    1805                 1810                 1815             


His Ser  Thr Met Leu Arg Gly  Glu Ile Glu Pro Tyr  Arg Glu Tyr 
    1820                 1825                 1830             


Leu Ser  Glu Arg Ile Lys Val  Gly Asp Val Lys Pro  Cys Glu Leu 
    1835                 1840                 1845             


Val Gly  Arg Trp Ile Pro Asn  Val Val Gly Gln Pro  Phe Ser Val 
    1850                 1855                 1860             


Asp Lys  Ser Tyr Val Gln Leu  Val His Gly Ile Thr  Gly Ser Pro 
    1865                 1870                 1875             


Arg Leu  His Ser Leu Leu Gln  Gln Met Ala 
    1880                 1885             


<210>  5
<211>  377
<212>  PRT
<213>  Mentha x piperita

<400>  5

Met Ser Ala Leu Val Asn Pro Val Ala Lys Trp Pro Gln Thr Ile Gly 
1               5                   10                  15      


Val Lys Asp Val His Gly Gly Arg Arg Arg Arg Ser Arg Ser Thr Leu 
            20                  25                  30          


Phe Gln Ser His Pro Leu Arg Thr Glu Met Pro Phe Ser Leu Tyr Phe 
        35                  40                  45              


Ser Ser Pro Leu Lys Ala Pro Ala Thr Phe Ser Val Ser Ala Val Tyr 
    50                  55                  60                  


Thr Lys Glu Gly Ser Glu Ile Arg Asp Lys Asp Pro Ala Pro Ser Thr 
65                  70                  75                  80  


Ser Pro Ala Phe Asp Phe Asp Gly Tyr Met Leu Arg Lys Ala Lys Ser 
                85                  90                  95      


Val Asn Lys Ala Leu Glu Ala Ala Val Gln Met Lys Glu Pro Leu Lys 
            100                 105                 110         


Ile His Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val 
        115                 120                 125             


Arg Pro Met Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Asp Glu 
    130                 135                 140                 


Ser Thr Ala Met Pro Ala Ala Cys Ala Val Glu Met Ile His Thr Met 
145                 150                 155                 160 


Ser Leu Met His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Leu Arg 
                165                 170                 175     


Arg Gly Lys Pro Thr Asn His Met Ala Phe Gly Glu Ser Val Ala Val 
            180                 185                 190         


Leu Ala Gly Asp Ala Leu Leu Ser Phe Ala Phe Glu His Val Ala Ala 
        195                 200                 205             


Ala Thr Lys Gly Ala Pro Pro Glu Arg Ile Val Arg Val Leu Gly Glu 
    210                 215                 220                 


Leu Ala Val Ser Ile Gly Ser Glu Gly Leu Val Ala Gly Gln Val Val 
225                 230                 235                 240 


Asp Val Cys Ser Glu Gly Met Ala Glu Val Gly Leu Asp His Leu Glu 
                245                 250                 255     


Phe Ile His His His Lys Thr Ala Ala Leu Leu Gln Gly Ser Val Val 
            260                 265                 270         


Leu Gly Ala Ile Leu Gly Gly Gly Lys Glu Glu Glu Val Ala Lys Leu 
        275                 280                 285             


Arg Lys Phe Ala Asn Cys Ile Gly Leu Leu Phe Gln Val Val Asp Asp 
    290                 295                 300                 


Ile Leu Asp Val Thr Lys Ser Ser Lys Glu Leu Gly Lys Thr Ala Gly 
305                 310                 315                 320 


Lys Asp Leu Val Ala Asp Lys Thr Thr Tyr Pro Lys Leu Ile Gly Val 
                325                 330                 335     


Glu Lys Ser Lys Glu Phe Ala Asp Arg Leu Asn Arg Glu Ala Gln Glu 
            340                 345                 350         


Gln Leu Leu His Phe His Pro His Arg Ala Ala Pro Leu Ile Ala Leu 
        355                 360                 365             


Ala Asn Tyr Ile Ala Tyr Arg Asp Asn 
    370                 375         


<210>  6
<211>  313
<212>  PRT
<213>  Mentha x piperita

<400>  6

Met Ala Ile Asn Leu Ser His Ile Asn Ser Lys Thr Cys Phe Pro Leu 
1               5                   10                  15      


Lys Thr Arg Ser Asp Leu Ser Arg Ser Ser Ser Ala Arg Cys Met Pro 
            20                  25                  30          


Thr Ala Ala Ala Ala Ala Phe Pro Thr Ile Ala Thr Ala Ala Gln Ser 
        35                  40                  45              


Gln Pro Tyr Trp Ala Ala Ile Glu Ala Asp Ile Glu Arg Tyr Leu Lys 
    50                  55                  60                  


Lys Ser Ile Thr Ile Arg Pro Pro Glu Thr Val Phe Gly Pro Met His 
65                  70                  75                  80  


His Leu Thr Phe Ala Ala Pro Ala Thr Ala Ala Ser Thr Leu Cys Leu 
                85                  90                  95      


Ala Ala Cys Glu Leu Val Gly Gly Asp Arg Ser Gln Ala Met Ala Ala 
            100                 105                 110         


Ala Ala Ala Ile His Leu Val His Ala Ala Ala Tyr Val His Glu His 
        115                 120                 125             


Leu Pro Leu Thr Asp Gly Ser Arg Pro Val Ser Lys Pro Ala Ile Gln 
    130                 135                 140                 


His Lys Tyr Gly Pro Asn Val Glu Leu Leu Thr Gly Asp Gly Ile Val 
145                 150                 155                 160 


Pro Phe Gly Phe Glu Leu Leu Ala Gly Ser Val Asp Pro Ala Arg Thr 
                165                 170                 175     


Asp Asp Pro Asp Arg Ile Leu Arg Val Ile Ile Glu Ile Ser Arg Ala 
            180                 185                 190         


Gly Gly Pro Glu Gly Met Ile Ser Gly Leu His Arg Glu Glu Glu Ile 
        195                 200                 205             


Val Asp Gly Asn Thr Ser Leu Asp Phe Ile Glu Tyr Val Cys Lys Lys 
    210                 215                 220                 


Lys Tyr Gly Glu Met His Ala Cys Gly Ala Ala Cys Gly Ala Ile Leu 
225                 230                 235                 240 


Gly Gly Ala Ala Glu Glu Glu Ile Gln Lys Leu Arg Asn Phe Gly Leu 
                245                 250                 255     


Tyr Gln Gly Thr Leu Arg Gly Met Met Glu Met Lys Asn Ser His Gln 
            260                 265                 270         


Leu Ile Asp Glu Asn Ile Ile Gly Lys Leu Lys Glu Leu Ala Leu Glu 
        275                 280                 285             


Glu Leu Gly Gly Phe His Gly Lys Asn Ala Glu Leu Met Ser Ser Leu 
    290                 295                 300                 


Val Ala Glu Pro Ser Leu Tyr Ala Ala 
305                 310             


<210>  7
<211>  352
<212>  PRT
<213>  Saccharomyces sp.

<400>  7

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Phe 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Asn Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  8
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated Erg20 farnesylpyrophosphate synthase (K197G)

<400>  8

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Phe 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Asn Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Gly Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  9
<211>  496
<212>  PRT
<213>  Rhizophagus irregularis

<400>  9

Met Arg Ala Gln Ala His Leu Gly Gly Gly Leu Lys Arg Ile Glu Thr 
1               5                   10                  15      


Gln His Gln Lys Gly Lys Leu Thr Ala Arg Glu Arg Ala Glu Leu Leu 
            20                  25                  30          


Leu Asp Pro Gly Ser Phe Asn Glu Tyr Asp Thr Phe Val Glu His Gln 
        35                  40                  45              


Cys Thr Asp Phe Gly Met Asp Lys Asn Lys Ile Ile Gly Asp Gly Val 
    50                  55                  60                  


Val Thr Gly His Gly Thr Ile Asn Gly Arg Arg Val Phe Thr Phe Ser 
65                  70                  75                  80  


Gln Asp Phe Thr Ala Phe Gly Gly Ser Leu Ser Lys Met His Ala Gln 
                85                  90                  95      


Lys Ile Cys Lys Ile Met Asp Lys Ala Met Leu Val Gly Ala Pro Val 
            100                 105                 110         


Ile Gly Leu Asn Asp Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Asp 
        115                 120                 125             


Ser Leu Ala Gly Tyr Ala Asp Ile Phe Gln Arg Asn Val Leu Ser Ser 
    130                 135                 140                 


Gly Val Val Pro Gln Leu Ser Leu Ile Met Gly Pro Cys Ala Gly Gly 
145                 150                 155                 160 


Ala Val Tyr Ser Pro Ala Leu Thr Asp Phe Thr Phe Met Val Arg Asp 
                165                 170                 175     


Thr Ser Tyr Leu Phe Val Thr Gly Pro Glu Val Val Lys Ala Val Cys 
            180                 185                 190         


Asn Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala Asn Thr His Thr 
        195                 200                 205             


Val Ile Ser Gly Val Ala His Ala Ala Phe Glu Asn Asp Ile Glu Ala 
    210                 215                 220                 


Ile Gln Arg Ile Arg Asp Phe Met Asp Phe Leu Pro Leu Ser Asn Arg 
225                 230                 235                 240 


Glu Gln Ala Pro Thr Arg Tyr Ser Asp Asp Pro Ile Asp Arg Glu Asp 
                245                 250                 255     


Pro Ser Leu Asn His Ile Ile Pro Val Asp Ser Thr Lys Ala Tyr Asp 
            260                 265                 270         


Met Arg Glu Ile Ile Thr Arg Leu Ile Asp Asp Gly His Phe Phe Glu 
        275                 280                 285             


Ile Met Pro Asp Tyr Ala Lys Asn Ile Val Val Gly Phe Ala Arg Met 
    290                 295                 300                 


Gly Gly Lys Thr Val Ser Ile Val Gly Asn Gln Pro Leu Val Ser Ser 
305                 310                 315                 320 


Gly Val Leu Asp Ile Asn Ser Ser Val Lys Ala Ala Arg Phe Val Arg 
                325                 330                 335     


Phe Cys Asp Ala Phe Asn Ile Pro Ile Ile Thr Leu Val Asp Val Pro 
            340                 345                 350         


Gly Phe Leu Pro Gly Thr Ala Gln Glu His Asn Gly Ile Ile Arg His 
        355                 360                 365             


Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr Val Pro Lys Ile 
    370                 375                 380                 


Thr Ile Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser 
385                 390                 395                 400 


Ser Lys His Leu Arg Gly Asp Met Asn Tyr Ser Trp Pro Thr Gly Glu 
                405                 410                 415     


Ile Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile Ile Phe Arg His 
            420                 425                 430         


Val Glu Asp Arg Thr Gln Ser Glu His Glu Tyr Ile Asp Lys Phe Ala 
        435                 440                 445             


Asn Pro Ile Pro Ala Ala Gln Arg Gly Tyr Ile Asp Asp Ile Ile Leu 
    450                 455                 460                 


Pro Ala Ala Thr Arg Lys Arg Ile Ile Glu Asp Leu Phe Val Leu Ser 
465                 470                 475                 480 


His Lys Gln Leu Pro Leu Ile Tyr Lys Lys His Asp Asn Cys Pro Leu 
                485                 490                 495     


<210>  10
<211>  101
<212>  PRT
<213>  Cannabis sativa

<400>  10

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  11
<211>  385
<212>  PRT
<213>  Cannabis sativa

<400>  11

Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr 
385 


<210>  12
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase (GOT)

<400>  12

Met Asn Ser Ile Arg Ala Ala Thr Thr Asn Gln Thr Glu Pro Pro Glu 
1               5                   10                  15      


Ser Asp Asn His Ser Val Ala Thr Lys Ile Leu Asn Phe Gly Lys Ala 
            20                  25                  30          


Cys Trp Lys Leu Gln Arg Pro Tyr Thr Ile Ile Ala Phe Thr Ser Cys 
        35                  40                  45              


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
    50                  55                  60                  


Ser Trp Ser Leu Met Phe Lys Ala Phe Phe Phe Leu Val Ala Ile Leu 
65                  70                  75                  80  


Cys Ile Ala Ser Phe Thr Thr Thr Ile Asn Gln Ile Tyr Asp Leu His 
                85                  90                  95      


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Ala Ser Gly Glu Ile 
            100                 105                 110         


Ser Val Asn Thr Ala Trp Ile Met Ser Ile Ile Val Ala Leu Phe Gly 
        115                 120                 125             


Leu Ile Ile Thr Ile Lys Met Lys Gly Gly Pro Leu Tyr Ile Phe Gly 
    130                 135                 140                 


Tyr Cys Phe Gly Ile Phe Gly Gly Ile Val Tyr Ser Val Pro Pro Phe 
145                 150                 155                 160 


Arg Trp Lys Gln Asn Pro Ser Thr Ala Phe Leu Leu Asn Phe Leu Ala 
                165                 170                 175     


His Ile Ile Thr Asn Phe Thr Phe Tyr Tyr Ala Ser Arg Ala Ala Leu 
            180                 185                 190         


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
        195                 200                 205             


Met Lys Ser Met Gly Ser Ala Leu Ala Leu Ile Lys Asp Ala Ser Asp 
    210                 215                 220                 


Val Glu Gly Asp Thr Lys Phe Gly Ile Ser Thr Leu Ala Ser Lys Tyr 
225                 230                 235                 240 


Gly Ser Arg Asn Leu Thr Leu Phe Cys Ser Gly Ile Val Leu Leu Ser 
                245                 250                 255     


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
            260                 265                 270         


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile 
        275                 280                 285             


Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly 
    290                 295                 300                 


Arg Arg Phe Tyr Glu Phe Met Trp Lys Leu Tyr Tyr Ala Glu Tyr Leu 
305                 310                 315                 320 


Val Tyr Val Phe Ile Gly Ser 
                325         


<210>  13
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered geranyl pyrophosphate olivetolic acid 
       geranyltransferase (GOT)

<400>  13

Met Lys Asp Gln Arg Gly Asn Ser Ile Arg Ala Ser Ala Gln Ile Glu 
1               5                   10                  15      


Asp Arg Pro Pro Glu Ser Gly Asn Leu Ser Ala Leu Thr Asn Val Lys 
            20                  25                  30          


Asp Phe Val Ser Val Cys Trp Glu Tyr Val Arg Pro Tyr Thr Ala Lys 
        35                  40                  45              


Gly Val Ile Ile Cys Ser Ser Cys Leu Phe Gly Arg Glu Leu Leu Glu 
    50                  55                  60                  


Asn Pro Asn Leu Phe Ser Trp Pro Leu Ile Phe Lys Ala Phe Phe Phe 
65                  70                  75                  80  


Leu Val Ala Ile Leu Cys Ile Ala Ser Phe Thr Thr Thr Ile Asn Gln 
                85                  90                  95      


Ile Tyr Asp Leu His Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu 
            100                 105                 110         


Ala Ser Gly Glu Ile Ser Val Asn Thr Ala Trp Ile Met Ser Ile Ile 
        115                 120                 125             


Val Ala Leu Phe Gly Leu Ile Ile Thr Ile Lys Met Lys Gly Gly Pro 
    130                 135                 140                 


Leu Tyr Ile Phe Gly Tyr Cys Phe Gly Ile Phe Gly Gly Ile Val Tyr 
145                 150                 155                 160 


Ser Val Pro Pro Phe Arg Trp Lys Gln Asn Pro Ser Thr Ala Phe Leu 
                165                 170                 175     


Leu Asn Phe Leu Ala His Ile Ile Thr Asn Phe Thr Phe Tyr Tyr Ala 
            180                 185                 190         


Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr 
        195                 200                 205             


Phe Leu Leu Ala Phe Met Lys Ser Met Gly Ser Ala Leu Ala Leu Ile 
    210                 215                 220                 


Lys Asp Ala Ser Asp Val Glu Gly Asp Thr Lys Phe Gly Ile Ser Thr 
225                 230                 235                 240 


Leu Ala Ser Lys Tyr Gly Ser Arg Asn Leu Thr Leu Phe Cys Ser Gly 
                245                 250                 255     


Ile Val Leu Leu Ser Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp 
            260                 265                 270         


Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser His Ala Ile Leu 
        275                 280                 285             


Ala Phe Trp Leu Ile Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn Tyr 
    290                 295                 300                 


Asp Pro Glu Ala Gly Arg Arg Phe Tyr Glu Phe Met Trp Lys Leu Tyr 
305                 310                 315                 320 


Tyr Ala Glu Tyr Leu Val Tyr Val Phe Ile Gly Ser 
                325                 330         


<210>  14
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant tetrahydro cannabinolic acid synthase (THCAS)

<400>  14

Met Asn Cys Ser Ala Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Leu Ser Phe His Ile Gln Ile Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Lys His Ile Pro Asn Asn Val Ala Asn 
        35                  40                  45              


Pro Lys Leu Val Tyr Thr Gln His Asp Gln Leu Tyr Met Ser Ile Leu 
    50                  55                  60                  


Asn Ser Thr Ile Gln Asn Leu Arg Phe Ile Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser Asn Asn Ser His Ile Gln Ala Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Val Val Asp Leu Arg Asn Met His Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Ile Asn Glu Lys Asn Glu Asn Leu Ser Phe Pro Gly Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Gly Val Gly Gly His Phe Ser Gly Gly Gly Tyr Gly Ala 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly Glu Asn Phe Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val Pro Ser Lys Ser Thr 
                245                 250                 255     


Ile Phe Ser Val Lys Lys Asn Met Glu Ile His Gly Leu Val Lys Leu 
            260                 265                 270         


Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Val 
        275                 280                 285             


Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr Asp Asn His Gly Lys 
    290                 295                 300                 


Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser Ile Phe His Gly Gly 
305                 310                 315                 320 


Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly 
                325                 330                 335     


Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp Ile Asp Thr Thr Ile 
            340                 345                 350         


Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala Asn Phe Lys Lys Glu 
        355                 360                 365             


Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr Ala Phe Ser Ile Lys 
    370                 375                 380                 


Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr Ala Met Val Lys Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Ala Gly Met Tyr Val Leu 
                405                 410                 415     


Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser Glu Ser Ala Ile Pro 
            420                 425                 430         


Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Thr Ala Ser 
        435                 440                 445             


Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile Asn Trp Val Arg Ser 
    450                 455                 460                 


Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln Asn Pro Arg Leu Ala 
465                 470                 475                 480 


Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys Thr Asn His Ala Ser 
                485                 490                 495     


Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly 
            500                 505                 510         


Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr Lys Val Asp Pro Asn 
        515                 520                 525             


Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Pro His His 
    530                 535                 540                 


His Gly Ser 
545         


<210>  15
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated tetrahydro cannabinolic acid synthase (THCAS)

<400>  15

Met Asn Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Lys His Ile Pro 
1               5                   10                  15      


Asn Asn Val Ala Asn Pro Lys Leu Val Tyr Thr Gln His Asp Gln Leu 
            20                  25                  30          


Tyr Met Ser Ile Leu Asn Ser Thr Ile Gln Asn Leu Arg Phe Ile Ser 
        35                  40                  45              


Asp Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser Asn Asn Ser 
    50                  55                  60                  


His Ile Gln Ala Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile 
65                  70                  75                  80  


Arg Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser 
                85                  90                  95      


Gln Val Pro Phe Val Val Val Asp Leu Arg Asn Met His Ser Ile Lys 
            100                 105                 110         


Ile Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu 
        115                 120                 125             


Gly Glu Val Tyr Tyr Trp Ile Asn Glu Lys Asn Glu Asn Leu Ser Phe 
    130                 135                 140                 


Pro Gly Gly Tyr Cys Pro Thr Val Gly Val Gly Gly His Phe Ser Gly 
145                 150                 155                 160 


Gly Gly Tyr Gly Ala Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn 
                165                 170                 175     


Ile Ile Asp Ala His Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg 
            180                 185                 190         


Lys Ser Met Gly Glu Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly 
        195                 200                 205             


Glu Asn Phe Gly Ile Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val 
    210                 215                 220                 


Pro Ser Lys Ser Thr Ile Phe Ser Val Lys Lys Asn Met Glu Ile His 
225                 230                 235                 240 


Gly Leu Val Lys Leu Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr 
                245                 250                 255     


Asp Lys Asp Leu Val Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr 
            260                 265                 270         


Asp Asn His Gly Lys Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser 
        275                 280                 285             


Ile Phe His Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser 
    290                 295                 300                 


Phe Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp 
305                 310                 315                 320 


Ile Asp Thr Thr Ile Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala 
                325                 330                 335     


Asn Phe Lys Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr 
            340                 345                 350         


Ala Phe Ser Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr 
        355                 360                 365             


Ala Met Val Lys Ile Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Ala 
    370                 375                 380                 


Gly Met Tyr Val Leu Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser 
385                 390                 395                 400 


Glu Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu 
                405                 410                 415     


Trp Tyr Thr Ala Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile 
            420                 425                 430         


Asn Trp Val Arg Ser Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln 
        435                 440                 445             


Asn Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys 
    450                 455                 460                 


Thr Asn His Ala Ser Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly 
465                 470                 475                 480 


Glu Lys Tyr Phe Gly Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr 
                485                 490                 495     


Lys Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro 
            500                 505                 510         


Leu Pro Pro His His His Gly Ser 
        515                 520 


<210>  16
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated cannabidiolic acid synthase (CBDAS)

<400>  16

Met Asn Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro 
1               5                   10                  15      


Asn Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu 
            20                  25                  30          


Tyr Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser 
        35                  40                  45              


Asp Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser 
    50                  55                  60                  


His Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile 
65                  70                  75                  80  


Arg Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser 
                85                  90                  95      


Gln Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys 
            100                 105                 110         


Ile Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu 
        115                 120                 125             


Gly Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu 
    130                 135                 140                 


Ala Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly 
145                 150                 155                 160 


Gly Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn 
                165                 170                 175     


Ile Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg 
            180                 185                 190         


Lys Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala 
        195                 200                 205             


Glu Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val 
    210                 215                 220                 


Pro Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly Ser 
        515                 


<210>  17
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR)

<400>  17

Met Val Leu Thr Asn Lys Thr Val Ile Ser Gly Ser Lys Val Lys Ser 
1               5                   10                  15      


Leu Ser Ser Ala Gln Ser Ser Ser Ser Gly Pro Ser Ser Ser Ser Glu 
            20                  25                  30          


Glu Asp Asp Ser Arg Asp Ile Glu Ser Leu Asp Lys Lys Ile Arg Pro 
        35                  40                  45              


Leu Glu Glu Leu Glu Ala Leu Leu Ser Ser Gly Asn Thr Lys Gln Leu 
    50                  55                  60                  


Lys Asn Lys Glu Val Ala Ala Leu Val Ile His Gly Lys Leu Pro Leu 
65                  70                  75                  80  


Tyr Ala Leu Glu Lys Lys Leu Gly Asp Thr Thr Arg Ala Val Ala Val 
                85                  90                  95      


Arg Arg Lys Ala Leu Ser Ile Leu Ala Glu Ala Pro Val Leu Ala Ser 
            100                 105                 110         


Asp Arg Leu Pro Tyr Lys Asn Tyr Asp Tyr Asp Arg Val Phe Gly Ala 
        115                 120                 125             


Cys Cys Glu Asn Val Ile Gly Tyr Met Pro Leu Pro Val Gly Val Ile 
    130                 135                 140                 


Gly Pro Leu Val Ile Asp Gly Thr Ser Tyr His Ile Pro Met Ala Thr 
145                 150                 155                 160 


Thr Glu Gly Cys Leu Val Ala Ser Ala Met Arg Gly Cys Lys Ala Ile 
                165                 170                 175     


Asn Ala Gly Gly Gly Ala Thr Thr Val Leu Thr Lys Asp Gly Met Thr 
            180                 185                 190         


Arg Gly Pro Val Val Arg Phe Pro Thr Leu Lys Arg Ser Gly Ala Cys 
        195                 200                 205             


Lys Ile Trp Leu Asp Ser Glu Glu Gly Gln Asn Ala Ile Lys Lys Ala 
    210                 215                 220                 


Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu Gln His Ile Gln Thr Cys 
225                 230                 235                 240 


Leu Ala Gly Asp Leu Leu Phe Met Arg Phe Arg Thr Thr Thr Gly Asp 
                245                 250                 255     


Ala Met Gly Met Asn Met Ile Ser Lys Gly Val Glu Tyr Ser Leu Lys 
            260                 265                 270         


Gln Met Val Glu Glu Tyr Gly Trp Glu Asp Met Glu Val Val Ser Val 
        275                 280                 285             


Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile 
    290                 295                 300                 


Glu Gly Arg Gly Lys Ser Val Val Ala Glu Ala Thr Ile Pro Gly Asp 
305                 310                 315                 320 


Val Val Arg Lys Val Leu Lys Ser Asp Val Ser Ala Leu Val Glu Leu 
                325                 330                 335     


Asn Ile Ala Lys Asn Leu Val Gly Ser Ala Met Ala Gly Ser Val Gly 
            340                 345                 350         


Gly Phe Asn Ala His Ala Ala Asn Leu Val Thr Ala Val Phe Leu Ala 
        355                 360                 365             


Leu Gly Gln Asp Pro Ala Gln Asn Val Glu Ser Ser Asn Cys Ile Thr 
    370                 375                 380                 


Leu Met Lys Glu Val Asp Gly Asp Leu Arg Ile Ser Val Ser Met Pro 
385                 390                 395                 400 


Ser Ile Glu Val Gly Thr Ile Gly Gly Gly Thr Val Leu Glu Pro Gln 
                405                 410                 415     


Gly Ala Met Leu Asp Leu Leu Gly Val Arg Gly Pro His Ala Thr Ala 
            420                 425                 430         


Pro Gly Thr Asn Ala Arg Gln Leu Ala Arg Ile Val Ala Cys Ala Val 
        435                 440                 445             


Leu Ala Gly Glu Leu Ser Leu Cys Ala Ala Leu Ala Ala Gly His Leu 
    450                 455                 460                 


Val Gln Ser His Met Thr His Asn Arg Lys Pro Ala Glu Pro Thr Lys 
465                 470                 475                 480 


Pro Asn Asn Leu Asp Ala Thr Asp Ile Asn Arg Leu Lys Asp Gly Ser 
                485                 490                 495     


Val Thr Cys Ile Lys Ser 
            500         


<210>  18
<211>  284
<212>  PRT
<213>  Ralstonia sp.

<400>  18

Met Ser Ile Arg Thr Val Gly Ile Val Gly Ala Gly Thr Met Gly Asn 
1               5                   10                  15      


Gly Ile Ala Gln Ala Cys Ala Val Val Gly Leu Asn Val Val Met Val 
            20                  25                  30          


Asp Ile Ser Asp Ala Ala Val Gln Lys Gly Val Ala Thr Val Ala Ser 
        35                  40                  45              


Ser Leu Asp Arg Leu Ile Lys Lys Glu Lys Leu Thr Glu Ala Asp Lys 
    50                  55                  60                  


Ala Ser Ala Leu Ala Arg Ile Lys Gly Ser Thr Ser Tyr Asp Asp Leu 
65                  70                  75                  80  


Lys Ala Thr Asp Ile Val Ile Glu Ala Ala Thr Glu Asn Tyr Asp Leu 
                85                  90                  95      


Lys Val Lys Ile Leu Lys Gln Ile Asp Gly Ile Val Gly Glu Asn Val 
            100                 105                 110         


Ile Ile Ala Ser Asn Thr Ser Ser Ile Ser Ile Thr Lys Leu Ala Ala 
        115                 120                 125             


Val Thr Ser Arg Ala Asp Arg Phe Ile Gly Met His Phe Phe Asn Pro 
    130                 135                 140                 


Val Pro Val Met Ala Leu Val Glu Leu Ile Arg Gly Leu Gln Thr Ser 
145                 150                 155                 160 


Asp Thr Thr His Ala Ala Val Glu Ala Leu Ser Lys Gln Leu Gly Lys 
                165                 170                 175     


Tyr Pro Ile Thr Val Lys Asn Ser Pro Gly Phe Val Val Asn Arg Ile 
            180                 185                 190         


Leu Cys Pro Met Ile Asn Glu Ala Phe Cys Val Leu Gly Glu Gly Leu 
        195                 200                 205             


Ala Ser Pro Glu Glu Ile Asp Glu Gly Met Lys Leu Gly Cys Asn His 
    210                 215                 220                 


Pro Ile Gly Pro Leu Ala Leu Ala Asp Met Ile Gly Leu Asp Thr Met 
225                 230                 235                 240 


Leu Ala Val Met Glu Val Leu Tyr Thr Glu Phe Ala Asp Pro Lys Tyr 
                245                 250                 255     


Arg Pro Ala Met Leu Met Arg Glu Met Val Ala Ala Gly Tyr Leu Gly 
            260                 265                 270         


Arg Lys Thr Gly Arg Gly Val Tyr Val Tyr Ser Lys 
        275                 280                 


<210>  19
<211>  261
<212>  PRT
<213>  Clostridium sp.

<400>  19

Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val 
1               5                   10                  15      


Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr 
            20                  25                  30          


Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu 
        35                  40                  45              


Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala 
    50                  55                  60                  


Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg 
65                  70                  75                  80  


Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu 
                85                  90                  95      


Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly 
            100                 105                 110         


Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala 
        115                 120                 125             


Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly 
    130                 135                 140                 


Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln 
145                 150                 155                 160 


Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile 
                165                 170                 175     


Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala 
            180                 185                 190         


Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys 
        195                 200                 205             


Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr 
    210                 215                 220                 


Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu 
225                 230                 235                 240 


Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu 
                245                 250                 255     


Gly Phe Lys Asn Arg 
            260     


<210>  20
<211>  397
<212>  PRT
<213>  Treponema sp.

<400>  20

Met Ile Val Lys Pro Met Val Arg Asn Asn Ile Cys Leu Asn Ala His 
1               5                   10                  15      


Pro Gln Gly Cys Lys Lys Gly Val Glu Asp Gln Ile Glu Tyr Thr Lys 
            20                  25                  30          


Lys Arg Ile Thr Ala Glu Val Lys Ala Gly Ala Lys Ala Pro Lys Asn 
        35                  40                  45              


Val Leu Val Leu Gly Cys Ser Asn Gly Tyr Gly Leu Ala Ser Arg Ile 
    50                  55                  60                  


Thr Ala Ala Phe Gly Tyr Gly Ala Ala Thr Ile Gly Val Ser Phe Glu 
65                  70                  75                  80  


Lys Ala Gly Ser Glu Thr Lys Tyr Gly Thr Pro Gly Trp Tyr Asn Asn 
                85                  90                  95      


Leu Ala Phe Asp Glu Ala Ala Lys Arg Glu Gly Leu Tyr Ser Val Thr 
            100                 105                 110         


Ile Asp Gly Asp Ala Phe Ser Asp Glu Ile Lys Ala Gln Val Ile Glu 
        115                 120                 125             


Glu Ala Lys Lys Lys Gly Ile Lys Phe Asp Leu Ile Val Tyr Ser Leu 
    130                 135                 140                 


Ala Ser Pro Val Arg Thr Asp Pro Asp Thr Gly Ile Met His Lys Ser 
145                 150                 155                 160 


Val Leu Lys Pro Phe Gly Lys Thr Phe Thr Gly Lys Thr Val Asp Pro 
                165                 170                 175     


Phe Thr Gly Glu Leu Lys Glu Ile Ser Ala Glu Pro Ala Asn Asp Glu 
            180                 185                 190         


Glu Ala Ala Ala Thr Val Lys Val Met Gly Gly Glu Asp Trp Glu Arg 
        195                 200                 205             


Trp Ile Lys Gln Leu Ser Lys Glu Gly Leu Leu Glu Glu Gly Cys Ile 
    210                 215                 220                 


Thr Leu Ala Tyr Ser Tyr Ile Gly Pro Glu Ala Thr Gln Ala Leu Tyr 
225                 230                 235                 240 


Arg Lys Gly Thr Ile Gly Lys Ala Lys Glu His Leu Glu Ala Thr Ala 
                245                 250                 255     


His Arg Leu Asn Lys Glu Asn Pro Ser Ile Arg Ala Phe Val Ser Val 
            260                 265                 270         


Asn Lys Gly Leu Val Thr Arg Ala Ser Ala Val Ile Pro Val Ile Pro 
        275                 280                 285             


Leu Tyr Leu Ala Ser Leu Phe Lys Val Met Lys Glu Lys Gly Asn His 
    290                 295                 300                 


Glu Gly Cys Ile Glu Gln Ile Thr Arg Leu Tyr Ala Glu Arg Leu Tyr 
305                 310                 315                 320 


Arg Lys Asp Gly Thr Ile Pro Val Asp Glu Glu Asn Arg Ile Arg Ile 
                325                 330                 335     


Asp Asp Trp Glu Leu Glu Glu Asp Val Gln Lys Ala Val Ser Ala Leu 
            340                 345                 350         


Met Glu Lys Val Thr Gly Glu Asn Ala Glu Ser Leu Thr Asp Leu Ala 
        355                 360                 365             


Gly Tyr Arg His Asp Phe Leu Ala Ser Asn Gly Phe Asp Val Glu Gly 
    370                 375                 380                 


Ile Asn Tyr Glu Ala Glu Val Glu Arg Phe Asp Arg Ile 
385                 390                 395         


<210>  21
<211>  394
<212>  PRT
<213>  Ralstonia sp.

<400>  21

Met Thr Arg Glu Val Val Val Val Ser Gly Val Arg Thr Ala Ile Gly 
1               5                   10                  15      


Thr Phe Gly Gly Ser Leu Lys Asp Val Ala Pro Ala Glu Leu Gly Ala 
            20                  25                  30          


Leu Val Val Arg Glu Ala Leu Ala Arg Ala Gln Val Ser Gly Asp Asp 
        35                  40                  45              


Val Gly His Val Val Phe Gly Asn Val Ile Gln Thr Glu Pro Arg Asp 
    50                  55                  60                  


Met Tyr Leu Gly Arg Val Ala Ala Val Asn Gly Gly Val Thr Ile Asn 
65                  70                  75                  80  


Ala Pro Ala Leu Thr Val Asn Arg Leu Cys Gly Ser Gly Leu Gln Ala 
                85                  90                  95      


Ile Val Ser Ala Ala Gln Thr Ile Leu Leu Gly Asp Thr Asp Val Ala 
            100                 105                 110         


Ile Gly Gly Gly Ala Glu Ser Met Ser Arg Ala Pro Tyr Leu Ala Pro 
        115                 120                 125             


Ala Ala Arg Trp Gly Ala Arg Met Gly Asp Ala Gly Leu Val Asp Met 
    130                 135                 140                 


Met Leu Gly Ala Leu His Asp Pro Phe His Arg Ile His Met Gly Val 
145                 150                 155                 160 


Thr Ala Glu Asn Val Ala Lys Glu Tyr Asp Ile Ser Arg Ala Gln Gln 
                165                 170                 175     


Asp Glu Ala Ala Leu Glu Ser His Arg Arg Ala Ser Ala Ala Ile Lys 
            180                 185                 190         


Ala Gly Tyr Phe Lys Asp Gln Ile Val Pro Val Val Ser Lys Gly Arg 
        195                 200                 205             


Lys Gly Asp Val Thr Phe Asp Thr Asp Glu His Val Arg His Asp Ala 
    210                 215                 220                 


Thr Ile Asp Asp Met Thr Lys Leu Arg Pro Val Phe Val Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Ala Ala Ala 
                245                 250                 255     


Ala Val Val Met Met Glu Arg Ala Glu Ala Glu Arg Arg Gly Leu Lys 
            260                 265                 270         


Pro Leu Ala Arg Leu Val Ser Tyr Gly His Ala Gly Val Asp Pro Lys 
        275                 280                 285             


Ala Met Gly Ile Gly Pro Val Pro Ala Thr Lys Ile Ala Leu Glu Arg 
    290                 295                 300                 


Ala Gly Leu Gln Val Ser Asp Leu Asp Val Ile Glu Ala Asn Glu Ala 
305                 310                 315                 320 


Phe Ala Ala Gln Ala Cys Ala Val Thr Lys Ala Leu Gly Leu Asp Pro 
                325                 330                 335     


Ala Lys Val Asn Pro Asn Gly Ser Gly Ile Ser Leu Gly His Pro Ile 
            340                 345                 350         


Gly Ala Thr Gly Ala Leu Ile Thr Val Lys Ala Leu His Glu Leu Asn 
        355                 360                 365             


Arg Val Gln Gly Arg Tyr Ala Leu Val Thr Met Cys Ile Gly Gly Gly 
    370                 375                 380                 


Gln Gly Ile Ala Ala Ile Phe Glu Arg Ile 
385                 390                 


<210>  22
<211>  813
<212>  PRT
<213>  Enterococcus sp.

<400>  22

Met Lys Glu Val Val Met Ile Asp Ala Ala Arg Thr Pro Ile Gly Lys 
1               5                   10                  15      


Tyr Arg Gly Ser Leu Ser Pro Phe Thr Ala Val Glu Leu Gly Thr Leu 
            20                  25                  30          


Val Thr Lys Gly Leu Leu Asp Lys Thr Lys Leu Lys Lys Asp Lys Ile 
        35                  40                  45              


Asp Gln Val Ile Phe Gly Asn Val Leu Gln Ala Gly Asn Gly Gln Asn 
    50                  55                  60                  


Val Ala Arg Gln Ile Ala Leu Asn Ser Gly Leu Pro Val Asp Val Pro 
65                  70                  75                  80  


Ala Met Thr Ile Asn Glu Val Cys Gly Ser Gly Met Lys Ala Val Ile 
                85                  90                  95      


Leu Ala Arg Gln Leu Ile Gln Leu Gly Glu Ala Glu Leu Val Ile Ala 
            100                 105                 110         


Gly Gly Thr Glu Ser Met Ser Gln Ala Pro Met Leu Lys Pro Tyr Gln 
        115                 120                 125             


Ser Glu Thr Asn Glu Tyr Gly Glu Pro Ile Ser Ser Met Val Asn Asp 
    130                 135                 140                 


Gly Leu Thr Asp Ala Phe Ser Asn Ala His Met Gly Leu Thr Ala Glu 
145                 150                 155                 160 


Lys Val Ala Thr Gln Phe Ser Val Ser Arg Glu Glu Gln Asp Arg Tyr 
                165                 170                 175     


Ala Leu Ser Ser Gln Leu Lys Ala Ala His Ala Val Glu Ala Gly Val 
            180                 185                 190         


Phe Ser Glu Glu Ile Ile Pro Val Lys Ile Ser Asp Glu Asp Val Leu 
        195                 200                 205             


Ser Glu Asp Glu Ala Val Arg Gly Asn Ser Thr Leu Glu Lys Leu Gly 
    210                 215                 220                 


Thr Leu Arg Thr Val Phe Ser Glu Glu Gly Thr Val Thr Ala Gly Asn 
225                 230                 235                 240 


Ala Ser Pro Leu Asn Asp Gly Ala Ser Val Val Ile Leu Ala Ser Lys 
                245                 250                 255     


Glu Tyr Ala Glu Asn Asn Asn Leu Pro Tyr Leu Ala Thr Ile Lys Glu 
            260                 265                 270         


Val Ala Glu Val Gly Ile Asp Pro Ser Ile Met Gly Ile Ala Pro Ile 
        275                 280                 285             


Lys Ala Ile Gln Lys Leu Thr Asp Arg Ser Gly Met Asn Leu Ser Thr 
    290                 295                 300                 


Ile Asp Leu Phe Glu Ile Asn Glu Ala Phe Ala Ala Ser Ser Ile Val 
305                 310                 315                 320 


Val Ser Gln Glu Leu Gln Leu Asp Glu Glu Lys Val Asn Ile Tyr Gly 
                325                 330                 335     


Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala Ser Gly Ala Arg Ile 
            340                 345                 350         


Leu Thr Thr Leu Ala Tyr Gly Leu Leu Arg Glu Gln Lys Arg Tyr Gly 
        355                 360                 365             


Ile Ala Ser Leu Cys Ile Gly Gly Gly Leu Gly Leu Ala Val Leu Leu 
    370                 375                 380                 


Glu Ala Asn Met Glu Gln Thr His Lys Asp Val Gln Lys Lys Lys Phe 
385                 390                 395                 400 


Tyr Gln Leu Thr Pro Ser Glu Arg Arg Ser Gln Leu Ile Glu Lys Asn 
                405                 410                 415     


Val Leu Thr Gln Glu Thr Ala Leu Ile Phe Gln Glu Gln Thr Leu Ser 
            420                 425                 430         


Glu Glu Leu Ser Asp His Met Ile Glu Asn Gln Val Ser Glu Val Glu 
        435                 440                 445             


Ile Pro Met Gly Ile Ala Gln Asn Phe Gln Ile Asn Gly Lys Lys Lys 
    450                 455                 460                 


Trp Ile Pro Met Ala Thr Glu Glu Pro Ser Val Ile Ala Ala Ala Ser 
465                 470                 475                 480 


Asn Gly Ala Lys Ile Cys Gly Asn Ile Cys Ala Glu Thr Pro Gln Arg 
                485                 490                 495     


Leu Met Arg Gly Gln Ile Val Leu Ser Gly Lys Ser Glu Tyr Gln Ala 
            500                 505                 510         


Val Ile Asn Ala Val Asn His Arg Lys Glu Glu Leu Ile Leu Cys Ala 
        515                 520                 525             


Asn Glu Ser Tyr Pro Ser Ile Val Lys Arg Gly Gly Gly Val Gln Asp 
    530                 535                 540                 


Ile Ser Thr Arg Glu Phe Met Gly Ser Phe His Ala Tyr Leu Ser Ile 
545                 550                 555                 560 


Asp Phe Leu Val Asp Val Lys Asp Ala Met Gly Ala Asn Met Ile Asn 
                565                 570                 575     


Ser Ile Leu Glu Ser Val Ala Asn Lys Leu Arg Glu Trp Phe Pro Glu 
            580                 585                 590         


Glu Glu Ile Leu Phe Ser Ile Leu Ser Asn Phe Ala Thr Glu Ser Leu 
        595                 600                 605             


Ala Ser Ala Cys Cys Glu Ile Pro Phe Glu Arg Leu Gly Arg Asn Lys 
    610                 615                 620                 


Glu Ile Gly Glu Gln Ile Ala Lys Lys Ile Gln Gln Ala Gly Glu Tyr 
625                 630                 635                 640 


Ala Lys Leu Asp Pro Tyr Arg Ala Ala Thr His Asn Lys Gly Ile Met 
                645                 650                 655     


Asn Gly Ile Glu Ala Val Val Ala Ala Thr Gly Asn Asp Thr Arg Ala 
            660                 665                 670         


Val Ser Ala Ser Ile His Ala Tyr Ala Ala Arg Asn Gly Leu Tyr Gln 
        675                 680                 685             


Gly Leu Thr Asp Trp Gln Ile Lys Gly Asp Lys Leu Val Gly Lys Leu 
    690                 695                 700                 


Thr Val Pro Leu Ala Val Ala Thr Val Gly Gly Ala Ser Asn Ile Leu 
705                 710                 715                 720 


Pro Lys Ala Lys Ala Ser Leu Ala Met Leu Asp Ile Asp Ser Ala Lys 
                725                 730                 735     


Glu Leu Ala Gln Val Ile Ala Ala Val Gly Leu Ala Gln Asn Leu Ala 
            740                 745                 750         


Ala Leu Arg Ala Leu Val Thr Glu Gly Ile Gln Lys Gly His Met Gly 
        755                 760                 765             


Leu Gln Ala Arg Ser Leu Ala Ile Ser Ile Gly Ala Ile Gly Glu Glu 
    770                 775                 780                 


Ile Glu Gln Val Ala Lys Lys Leu Arg Glu Ala Glu Lys Met Asn Gln 
785                 790                 795                 800 


Gln Thr Ala Ile Gln Ile Leu Glu Lys Ile Arg Glu Lys 
                805                 810             


<210>  23
<211>  389
<212>  PRT
<213>  Lactobacillus plantarum

<400>  23

Met Lys Ile Gly Ile Asp Lys Leu His Phe Ala Thr Ser His Leu Tyr 
1               5                   10                  15      


Val Asp Met Ala Glu Leu Ala Thr Ala Arg Gln Ala Glu Pro Asp Lys 
            20                  25                  30          


Tyr Leu Ile Gly Ile Gly Gln Ser Lys Met Ala Val Ile Pro Pro Ser 
        35                  40                  45              


Gln Asp Val Val Thr Leu Ala Ala Asn Ala Ala Ala Pro Met Leu Thr 
    50                  55                  60                  


Ala Thr Asp Ile Ala Ala Ile Asp Leu Leu Val Val Gly Thr Glu Ser 
65                  70                  75                  80  


Gly Ile Asp Asn Ser Lys Ala Ser Ala Ile Tyr Val Ala Lys Leu Leu 
                85                  90                  95      


Gly Leu Ser Gln Arg Val Arg Thr Ile Glu Met Lys Glu Ala Cys Tyr 
            100                 105                 110         


Ala Ala Thr Ala Gly Val Gln Leu Ala Gln Asp His Val Arg Val His 
        115                 120                 125             


Pro Asp Lys Lys Ala Leu Val Ile Gly Ser Asp Val Ala Arg Tyr Gly 
    130                 135                 140                 


Leu Asn Thr Pro Gly Glu Pro Thr Gln Gly Gly Gly Ala Val Ala Met 
145                 150                 155                 160 


Leu Ile Ser Ala Asp Pro Lys Val Leu Val Leu Gly Thr Glu Ser Ser 
                165                 170                 175     


Leu Leu Ser Glu Asp Val Met Asp Phe Trp Arg Pro Leu Tyr His Thr 
            180                 185                 190         


Glu Ala Leu Val Asp Gly Lys Tyr Ser Ser Asn Ile Tyr Ile Asp Tyr 
        195                 200                 205             


Phe Gln Asp Val Phe Lys Asn Tyr Leu Gln Thr Thr Gln Thr Ser Pro 
    210                 215                 220                 


Asp Thr Leu Thr Ala Leu Val Phe His Leu Pro Tyr Thr Lys Met Gly 
225                 230                 235                 240 


Leu Lys Ala Leu Arg Ser Val Leu Pro Leu Val Asp Ala Glu Lys Gln 
                245                 250                 255     


Ala Gln Trp Leu Ala His Phe Glu His Ala Arg Gln Leu Asn Arg Gln 
            260                 265                 270         


Val Gly Asn Leu Tyr Thr Gly Ser Leu Tyr Leu Ser Leu Leu Ser Gln 
        275                 280                 285             


Leu Leu Thr Asp Pro Gln Leu Gln Pro Gly Asn Arg Leu Gly Leu Phe 
    290                 295                 300                 


Ser Tyr Gly Ser Gly Ala Glu Gly Glu Phe Tyr Thr Gly Val Ile Gln 
305                 310                 315                 320 


Pro Asp Tyr Gln Thr Gly Leu Asp His Gly Leu Pro Gln Arg Leu Ala 
                325                 330                 335     


Arg Arg Arg Arg Val Ser Val Ala Glu Tyr Glu Ala Leu Phe Ser His 
            340                 345                 350         


Gln Leu Gln Trp Arg Ala Asp Asp Gln Ser Val Ser Tyr Ala Asp Asp 
        355                 360                 365             


Pro His Arg Phe Val Leu Thr Gly Gln Lys Asn Glu Gln Arg Gln Tyr 
    370                 375                 380                 


Leu Asp Gln Gln Val 
385                 


<210>  24
<211>  491
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Lys Leu Ser Thr Lys Leu Cys Trp Cys Gly Ile Lys Gly Arg Leu 
1               5                   10                  15      


Arg Pro Gln Lys Gln Gln Gln Leu His Asn Thr Asn Leu Gln Met Thr 
            20                  25                  30          


Glu Leu Lys Lys Gln Lys Thr Ala Glu Gln Lys Thr Arg Pro Gln Asn 
        35                  40                  45              


Val Gly Ile Lys Gly Ile Gln Ile Tyr Ile Pro Thr Gln Cys Val Asn 
    50                  55                  60                  


Gln Ser Glu Leu Glu Lys Phe Asp Gly Val Ser Gln Gly Lys Tyr Thr 
65                  70                  75                  80  


Ile Gly Leu Gly Gln Thr Asn Met Ser Phe Val Asn Asp Arg Glu Asp 
                85                  90                  95      


Ile Tyr Ser Met Ser Leu Thr Val Leu Ser Lys Leu Ile Lys Ser Tyr 
            100                 105                 110         


Asn Ile Asp Thr Asn Lys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
        115                 120                 125             


Leu Ile Asp Lys Ser Lys Ser Val Lys Ser Val Leu Met Gln Leu Phe 
    130                 135                 140                 


Gly Glu Asn Thr Asp Val Glu Gly Ile Asp Thr Leu Asn Ala Cys Tyr 
145                 150                 155                 160 


Gly Gly Thr Asn Ala Leu Phe Asn Ser Leu Asn Trp Ile Glu Ser Asn 
                165                 170                 175     


Ala Trp Asp Gly Arg Asp Ala Ile Val Val Cys Gly Asp Ile Ala Ile 
            180                 185                 190         


Tyr Asp Lys Gly Ala Ala Arg Pro Thr Gly Gly Ala Gly Thr Val Ala 
        195                 200                 205             


Met Trp Ile Gly Pro Asp Ala Pro Ile Val Phe Asp Ser Val Arg Ala 
    210                 215                 220                 


Ser Tyr Met Glu His Ala Tyr Asp Phe Tyr Lys Pro Asp Phe Thr Ser 
225                 230                 235                 240 


Glu Tyr Pro Tyr Val Asp Gly His Phe Ser Leu Thr Cys Tyr Val Lys 
                245                 250                 255     


Ala Leu Asp Gln Val Tyr Lys Ser Tyr Ser Lys Lys Ala Ile Ser Lys 
            260                 265                 270         


Gly Leu Val Ser Asp Pro Ala Gly Ser Asp Ala Leu Asn Val Leu Lys 
        275                 280                 285             


Tyr Phe Asp Tyr Asn Val Phe His Val Pro Thr Cys Lys Leu Val Thr 
    290                 295                 300                 


Lys Ser Tyr Gly Arg Leu Leu Tyr Asn Asp Phe Arg Ala Asn Pro Gln 
305                 310                 315                 320 


Leu Phe Pro Glu Val Asp Ala Glu Leu Ala Thr Arg Asp Tyr Asp Glu 
                325                 330                 335     


Ser Leu Thr Asp Lys Asn Ile Glu Lys Thr Phe Val Asn Val Ala Lys 
            340                 345                 350         


Pro Phe His Lys Glu Arg Val Ala Gln Ser Leu Ile Val Pro Thr Asn 
        355                 360                 365             


Thr Gly Asn Met Tyr Thr Ala Ser Val Tyr Ala Ala Phe Ala Ser Leu 
    370                 375                 380                 


Leu Asn Tyr Val Gly Ser Asp Asp Leu Gln Gly Lys Arg Val Gly Leu 
385                 390                 395                 400 


Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Leu Tyr Ser Cys Lys Ile 
                405                 410                 415     


Val Gly Asp Val Gln His Ile Ile Lys Glu Leu Asp Ile Thr Asn Lys 
            420                 425                 430         


Leu Ala Lys Arg Ile Thr Glu Thr Pro Lys Asp Tyr Glu Ala Ala Ile 
        435                 440                 445             


Glu Leu Arg Glu Asn Ala His Leu Lys Lys Asn Phe Lys Pro Gln Gly 
    450                 455                 460                 


Ser Ile Glu His Leu Gln Ser Gly Val Tyr Tyr Leu Thr Asn Ile Asp 
465                 470                 475                 480 


Asp Lys Phe Arg Arg Ser Tyr Asp Val Lys Lys 
                485                 490     


<210>  25
<211>  398
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Ser Gln Asn Val Tyr Ile Val Ser Thr Ala Arg Thr Pro Ile Gly 
1               5                   10                  15      


Ser Phe Gln Gly Ser Leu Ser Ser Lys Thr Ala Val Glu Leu Gly Ala 
            20                  25                  30          


Val Ala Leu Lys Gly Ala Leu Ala Lys Val Pro Glu Leu Asp Ala Ser 
        35                  40                  45              


Lys Asp Phe Asp Glu Ile Ile Phe Gly Asn Val Leu Ser Ala Asn Leu 
    50                  55                  60                  


Gly Gln Ala Pro Ala Arg Gln Val Ala Leu Ala Ala Gly Leu Ser Asn 
65                  70                  75                  80  


His Ile Val Ala Ser Thr Val Asn Lys Val Cys Ala Ser Ala Met Lys 
                85                  90                  95      


Ala Ile Ile Leu Gly Ala Gln Ser Ile Lys Cys Gly Asn Ala Asp Val 
            100                 105                 110         


Val Val Ala Gly Gly Cys Glu Ser Met Thr Asn Ala Pro Tyr Tyr Met 
        115                 120                 125             


Pro Ala Ala Arg Ala Gly Ala Lys Phe Gly Gln Thr Val Leu Val Asp 
    130                 135                 140                 


Gly Val Glu Arg Asp Gly Leu Asn Asp Ala Tyr Asp Gly Leu Ala Met 
145                 150                 155                 160 


Gly Val His Ala Glu Lys Cys Ala Arg Asp Trp Asp Ile Thr Arg Glu 
                165                 170                 175     


Gln Gln Asp Asn Phe Ala Ile Glu Ser Tyr Gln Lys Ser Gln Lys Ser 
            180                 185                 190         


Gln Lys Glu Gly Lys Phe Asp Asn Glu Ile Val Pro Val Thr Ile Lys 
        195                 200                 205             


Gly Phe Arg Gly Lys Pro Asp Thr Gln Val Thr Lys Asp Glu Glu Pro 
    210                 215                 220                 


Ala Arg Leu His Val Glu Lys Leu Arg Ser Ala Arg Thr Val Phe Gln 
225                 230                 235                 240 


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Pro Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Ile Leu Val Ser Glu Lys Val Leu Lys Glu Lys 
            260                 265                 270         


Asn Leu Lys Pro Leu Ala Ile Ile Lys Gly Trp Gly Glu Ala Ala His 
        275                 280                 285             


Gln Pro Ala Asp Phe Thr Trp Ala Pro Ser Leu Ala Val Pro Lys Ala 
    290                 295                 300                 


Leu Lys His Ala Gly Ile Glu Asp Ile Asn Ser Val Asp Tyr Phe Glu 
305                 310                 315                 320 


Phe Asn Glu Ala Phe Ser Val Val Gly Leu Val Asn Thr Lys Ile Leu 
                325                 330                 335     


Lys Leu Asp Pro Ser Lys Val Asn Val Tyr Gly Gly Ala Val Ala Leu 
            340                 345                 350         


Gly His Pro Leu Gly Cys Ser Gly Ala Arg Val Val Val Thr Leu Leu 
        355                 360                 365             


Ser Ile Leu Gln Gln Glu Gly Gly Lys Ile Gly Val Ala Ala Ile Cys 
    370                 375                 380                 


Asn Gly Gly Gly Gly Ala Ser Ser Ile Val Ile Glu Lys Ile 
385                 390                 395             


<210>  26
<211>  247
<212>  PRT
<213>  Bacteroides sp.

<400>  26

Met Ser Asp Asp Lys Lys Ile Gly Ser Tyr Lys Phe Ile Ala Glu Pro 
1               5                   10                  15      


Phe His Val Asp Phe Asn Gly Arg Leu Thr Met Gly Val Leu Gly Asn 
            20                  25                  30          


His Leu Leu Asn Cys Ala Gly Phe His Ala Ser Glu Arg Gly Phe Gly 
        35                  40                  45              


Ile Ala Thr Leu Asn Glu Asp Asn Tyr Thr Trp Val Leu Ser Arg Leu 
    50                  55                  60                  


Ala Ile Asp Leu Glu Glu Met Pro Tyr Gln Tyr Glu Glu Phe Thr Val 
65                  70                  75                  80  


Gln Thr Trp Val Glu Asn Val Tyr Arg Leu Phe Thr Asp Arg Asn Phe 
                85                  90                  95      


Ala Ile Ile Asp Lys Asp Gly Lys Lys Ile Gly Tyr Ala Arg Ser Val 
            100                 105                 110         


Trp Ala Met Ile Asn Leu Asn Thr Arg Lys Pro Ala Asp Leu Leu Thr 
        115                 120                 125             


Leu His Gly Gly Ser Ile Val Asp Tyr Val Cys Asp Glu Pro Cys Pro 
    130                 135                 140                 


Ile Glu Lys Pro Ser Arg Ile Lys Val Ala Thr Asp Gln Pro Cys Ala 
145                 150                 155                 160 


Lys Leu Thr Ala Lys Tyr Ser Asp Ile Asp Ile Asn Gly His Val Asn 
                165                 170                 175     


Ser Ile Arg Tyr Ile Glu His Ile Leu Asp Leu Phe Pro Ile Asp Leu 
            180                 185                 190         


Tyr Lys Ser Lys Arg Ile Gln Arg Phe Glu Met Ala Tyr Val Ala Glu 
        195                 200                 205             


Ser Tyr Tyr Gly Asp Glu Leu Ser Phe Phe Glu Glu Glu Val Ser Glu 
    210                 215                 220                 


Asn Glu Tyr His Val Glu Ile Lys Lys Asn Gly Ser Glu Val Val Cys 
225                 230                 235                 240 


Arg Ala Lys Val Lys Phe Val 
                245         


<210>  27
<211>  247
<212>  PRT
<213>  Bacteroides thetaiotaomicron

<400>  27

Met Ser Glu Glu Asn Lys Ile Gly Thr Tyr Gln Phe Val Ala Glu Pro 
1               5                   10                  15      


Phe His Val Asp Phe Asn Gly Arg Leu Thr Met Gly Val Leu Gly Asn 
            20                  25                  30          


His Leu Leu Asn Cys Ala Gly Phe His Ala Ser Asp Arg Gly Phe Gly 
        35                  40                  45              


Ile Ala Thr Leu Asn Glu Asp Asn Tyr Thr Trp Val Leu Ser Arg Leu 
    50                  55                  60                  


Ala Ile Glu Leu Asp Glu Met Pro Tyr Gln Tyr Glu Lys Phe Ser Val 
65                  70                  75                  80  


Gln Thr Trp Val Glu Asn Val Tyr Arg Leu Phe Thr Asp Arg Asn Phe 
                85                  90                  95      


Ala Val Ile Asp Lys Asp Gly Lys Lys Ile Gly Tyr Ala Arg Ser Val 
            100                 105                 110         


Trp Ala Met Ile Asn Leu Asn Thr Arg Lys Pro Ala Asp Leu Leu Ala 
        115                 120                 125             


Leu His Gly Gly Ser Ile Val Asp Tyr Ile Cys Asp Glu Pro Cys Pro 
    130                 135                 140                 


Ile Glu Lys Pro Ser Arg Ile Lys Val Thr Ser Asn Gln Pro Val Ala 
145                 150                 155                 160 


Thr Leu Thr Ala Lys Tyr Ser Asp Ile Asp Ile Asn Gly His Val Asn 
                165                 170                 175     


Ser Ile Arg Tyr Ile Glu His Ile Leu Asp Leu Phe Pro Ile Glu Leu 
            180                 185                 190         


Tyr Gln Thr Lys Arg Ile Arg Arg Phe Glu Met Ala Tyr Val Ala Glu 
        195                 200                 205             


Ser Tyr Phe Gly Asp Glu Leu Ser Phe Phe Cys Asp Glu Val Ser Glu 
    210                 215                 220                 


Asn Glu Phe His Val Glu Val Lys Lys Asn Gly Ser Glu Val Val Cys 
225                 230                 235                 240 


Arg Ser Lys Val Ile Phe Glu 
                245         


<210>  28
<211>  238
<212>  PRT
<213>  Bryantella formatexigen

<400>  28

Met Ile Tyr Met Ala Tyr Gln Tyr Arg Ser Arg Ile Arg Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Asp Lys Lys Leu Thr Leu Pro Gly Leu Val Asn Tyr Phe 
            20                  25                  30          


Gln Asp Cys Ser Thr Phe Gln Ser Glu Ala Leu Gly Ile Gly Leu Asp 
        35                  40                  45              


Thr Leu Gly Ala Arg Gln Arg Ala Trp Leu Leu Ala Ser Trp Lys Ile 
    50                  55                  60                  


Val Ile Asp Arg Leu Pro Arg Leu Gly Glu Glu Val Val Thr Glu Thr 
65                  70                  75                  80  


Trp Pro Tyr Gly Phe Lys Gly Phe Gln Gly Asn Arg Asn Phe Arg Met 
                85                  90                  95      


Leu Asp Gln Glu Gly His Thr Leu Ala Ala Ala Ala Ser Val Trp Ile 
            100                 105                 110         


Tyr Leu Asn Val Glu Ser Gly His Pro Cys Arg Ile Asp Gly Asp Val 
        115                 120                 125             


Leu Glu Ala Tyr Glu Leu Glu Glu Glu Leu Pro Leu Gly Pro Phe Ser 
    130                 135                 140                 


Arg Lys Ile Pro Val Pro Glu Glu Ser Thr Glu Arg Asp Ser Phe Leu 
145                 150                 155                 160 


Val Met Arg Ser His Leu Asp Thr Asn His His Val Asn Asn Gly Gln 
                165                 170                 175     


Tyr Ile Leu Met Ala Glu Glu Tyr Leu Pro Glu Gly Phe Lys Val Lys 
            180                 185                 190         


Gln Ile Arg Val Glu Tyr Arg Lys Ala Ala Val Leu His Asp Thr Ile 
        195                 200                 205             


Val Pro Phe Val Cys Thr Glu Pro Gln Arg Cys Thr Val Ser Leu Cys 
    210                 215                 220                 


Gly Ser Asp Glu Lys Pro Phe Ala Val Val Glu Phe Ser Glu 
225                 230                 235             


<210>  29
<211>  246
<212>  PRT
<213>  Lactobacillus brevis

<400>  29

Met Ala Ala Asn Glu Phe Ser Glu Thr His Arg Val Val Tyr Tyr Glu 
1               5                   10                  15      


Ala Asp Asp Thr Gly Gln Leu Thr Leu Ala Met Leu Ile Asn Leu Phe 
            20                  25                  30          


Val Leu Val Ser Glu Asp Gln Asn Asp Ala Leu Gly Leu Ser Thr Ala 
        35                  40                  45              


Phe Val Gln Ser His Gly Val Gly Trp Val Val Thr Gln Tyr His Leu 
    50                  55                  60                  


His Ile Asp Glu Leu Pro Arg Thr Gly Ala Gln Val Thr Ile Lys Thr 
65                  70                  75                  80  


Arg Ala Thr Ala Tyr Asn Arg Tyr Phe Ala Tyr Arg Glu Tyr Trp Leu 
                85                  90                  95      


Leu Asp Asp Ala Gly Gln Val Leu Ala Tyr Gly Glu Gly Ile Trp Val 
            100                 105                 110         


Thr Met Ser Tyr Ala Thr Arg Lys Ile Thr Thr Ile Pro Ala Glu Val 
        115                 120                 125             


Met Ala Pro Tyr His Ser Glu Glu Gln Thr Arg Leu Pro Arg Leu Pro 
    130                 135                 140                 


Arg Pro Asp His Phe Asp Glu Ala Val Asn Gln Thr Leu Lys Pro Tyr 
145                 150                 155                 160 


Thr Val Arg Tyr Phe Asp Ile Asp Gly Asn Gly His Val Asn Asn Ala 
                165                 170                 175     


His Tyr Phe Asp Trp Met Leu Asp Val Leu Pro Ala Thr Phe Leu Arg 
            180                 185                 190         


Ala His His Pro Thr Asp Val Lys Ile Arg Phe Glu Asn Glu Val Gln 
        195                 200                 205             


Tyr Gly His Gln Val Thr Ser Glu Leu Ser Gln Ala Ala Ala Leu Thr 
    210                 215                 220                 


Thr Gln His Met Ile Lys Val Gly Asp Leu Thr Ala Val Lys Ala Thr 
225                 230                 235                 240 


Ile Gln Trp Asp Asn Arg 
                245     


<210>  30
<211>  261
<212>  PRT
<213>  Lactobacillus plantarum

<400>  30

Met Ala Thr Leu Gly Ala Asn Ala Ser Leu Tyr Ser Glu Gln His Arg 
1               5                   10                  15      


Ile Thr Tyr Tyr Glu Cys Asp Arg Thr Gly Arg Ala Thr Leu Thr Thr 
            20                  25                  30          


Leu Ile Asp Ile Ala Val Leu Ala Ser Glu Asp Gln Ser Asp Ala Leu 
        35                  40                  45              


Gly Leu Thr Thr Glu Met Val Gln Ser His Gly Val Gly Trp Val Val 
    50                  55                  60                  


Thr Gln Tyr Ala Ile Asp Ile Thr Arg Met Pro Arg Gln Asp Glu Val 
65                  70                  75                  80  


Val Thr Ile Ala Val Arg Gly Ser Ala Tyr Asn Pro Tyr Phe Ala Tyr 
                85                  90                  95      


Arg Glu Phe Trp Ile Arg Asp Ala Asp Gly Gln Gln Leu Ala Tyr Ile 
            100                 105                 110         


Thr Ser Ile Trp Val Met Met Ser Gln Thr Thr Arg Arg Ile Val Lys 
        115                 120                 125             


Ile Leu Pro Glu Leu Val Ala Pro Tyr Gln Ser Glu Val Val Lys Arg 
    130                 135                 140                 


Ile Pro Arg Leu Pro Arg Pro Ile Ser Phe Glu Ala Thr Asp Thr Thr 
145                 150                 155                 160 


Ile Thr Lys Pro Tyr His Val Arg Phe Phe Asp Ile Asp Pro Asn Arg 
                165                 170                 175     


His Val Asn Asn Ala His Tyr Phe Asp Trp Leu Val Asp Thr Leu Pro 
            180                 185                 190         


Ala Thr Phe Leu Leu Gln His Asp Leu Val His Val Asp Val Arg Tyr 
        195                 200                 205             


Glu Asn Glu Val Lys Tyr Gly Gln Thr Val Thr Ala His Ala Asn Ile 
    210                 215                 220                 


Leu Pro Ser Glu Val Ala Asp Gln Val Thr Thr Ser His Leu Ile Glu 
225                 230                 235                 240 


Val Asp Asp Glu Lys Cys Cys Glu Val Thr Ile Gln Trp Arg Thr Leu 
                245                 250                 255     


Pro Glu Pro Ile Gln 
            260     


<210>  31
<211>  250
<212>  PRT
<213>  Streptococcus dysgalactiae

<400>  31

Met Gly Leu Ser Tyr Arg Glu Asp Ile Lys Leu Pro Phe Glu Leu Cys 
1               5                   10                  15      


Asp Val Lys Ser Asp Ile Lys Phe Pro Leu Leu Leu Asp Tyr Cys Leu 
            20                  25                  30          


Thr Val Ser Gly Arg Gln Ser Ala Gln Leu Gly Arg Ser Asn Asp Tyr 
        35                  40                  45              


Leu Leu Glu Gln Tyr Gly Leu Ile Trp Ile Val Thr Asp Tyr Glu Ala 
    50                  55                  60                  


Thr Ile His Arg Leu Pro His Phe Gln Glu Thr Ile Thr Ile Glu Thr 
65                  70                  75                  80  


Lys Ala Leu Ser Tyr Asn Lys Phe Phe Cys Tyr Arg Gln Phe Tyr Ile 
                85                  90                  95      


Tyr Asp Gln Glu Gly Gly Leu Leu Val Asp Ile Leu Ala Tyr Phe Ala 
            100                 105                 110         


Leu Leu Asn Pro Asp Thr Arg Lys Val Ala Thr Ile Pro Glu Asp Leu 
        115                 120                 125             


Val Ala Pro Phe Glu Thr Asp Phe Val Lys Lys Leu His Arg Val Pro 
    130                 135                 140                 


Lys Met Pro Leu Leu Glu Gln Ser Ile Asp Arg Asp Tyr Tyr Val Arg 
145                 150                 155                 160 


Tyr Phe Asp Ile Asp Met Asn Gly His Val Asn Asn Ser Lys Tyr Leu 
                165                 170                 175     


Asp Trp Met Tyr Asp Val Leu Gly Cys Glu Phe Leu Lys Thr His Gln 
            180                 185                 190         


Pro Leu Lys Met Thr Leu Lys Tyr Val Lys Glu Val Ser Pro Gly Gly 
        195                 200                 205             


Gln Ile Thr Ser Ser Tyr His Leu Asp Gln Leu Thr Ser Tyr His Gln 
    210                 215                 220                 


Ile Thr Ser Asp Gly Gln Leu Asn Ala Gln Ala Met Ile Glu Trp Arg 
225                 230                 235                 240 


Ala Ile Lys Gln Thr Glu Ser Glu Ile Asp 
                245                 250 


<210>  32
<211>  620
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Ser Phe Asp Ile Ala Lys Tyr Pro Thr Leu Ala Leu Val Asp Ser 
1               5                   10                  15      


Thr Gln Glu Leu Arg Leu Leu Pro Lys Glu Ser Leu Pro Lys Leu Cys 
            20                  25                  30          


Asp Glu Leu Arg Arg Tyr Leu Leu Asp Ser Val Ser Arg Ser Ser Gly 
        35                  40                  45              


His Phe Ala Ser Gly Leu Gly Thr Val Glu Leu Thr Val Ala Leu His 
    50                  55                  60                  


Tyr Val Tyr Asn Thr Pro Phe Asp Gln Leu Ile Trp Asp Val Gly His 
65                  70                  75                  80  


Gln Ala Tyr Pro His Lys Ile Leu Thr Gly Arg Arg Asp Lys Ile Gly 
                85                  90                  95      


Thr Ile Arg Gln Lys Gly Gly Leu His Pro Phe Pro Trp Arg Gly Glu 
            100                 105                 110         


Ser Glu Tyr Asp Val Leu Ser Val Gly His Ser Ser Thr Ser Ile Ser 
        115                 120                 125             


Ala Gly Ile Gly Ile Ala Val Ala Ala Glu Lys Glu Gly Lys Asn Arg 
    130                 135                 140                 


Arg Thr Val Cys Val Ile Gly Asp Gly Ala Ile Thr Ala Gly Met Ala 
145                 150                 155                 160 


Phe Glu Ala Met Asn His Ala Gly Asp Ile Arg Pro Asp Met Leu Val 
                165                 170                 175     


Ile Leu Asn Asp Asn Glu Met Ser Ile Ser Glu Asn Val Gly Ala Leu 
            180                 185                 190         


Asn Asn His Leu Ala Gln Leu Leu Ser Gly Lys Leu Tyr Ser Ser Leu 
        195                 200                 205             


Arg Glu Gly Gly Lys Lys Val Phe Ser Gly Val Pro Pro Ile Lys Glu 
    210                 215                 220                 


Leu Leu Lys Arg Thr Glu Glu His Ile Lys Gly Met Val Val Pro Gly 
225                 230                 235                 240 


Thr Leu Phe Glu Glu Leu Gly Phe Asn Tyr Ile Gly Pro Val Asp Gly 
                245                 250                 255     


His Asp Val Leu Gly Leu Ile Thr Thr Leu Lys Asn Met Arg Asp Leu 
            260                 265                 270         


Lys Gly Pro Gln Phe Leu His Ile Met Thr Lys Lys Gly Arg Gly Tyr 
        275                 280                 285             


Glu Pro Ala Glu Lys Asp Pro Ile Thr Phe His Ala Val Pro Lys Phe 
    290                 295                 300                 


Asp Pro Ser Ser Gly Cys Leu Pro Lys Ser Ser Gly Gly Leu Pro Ser 
305                 310                 315                 320 


Tyr Ser Lys Ile Phe Gly Asp Trp Leu Cys Glu Thr Ala Ala Lys Asp 
                325                 330                 335     


Asn Lys Leu Met Ala Ile Thr Pro Ala Met Arg Glu Gly Ser Gly Met 
            340                 345                 350         


Val Glu Phe Ser Arg Lys Phe Pro Asp Arg Tyr Phe Asp Val Ala Ile 
        355                 360                 365             


Ala Glu Gln His Ala Val Thr Phe Ala Ala Gly Leu Ala Ile Gly Gly 
    370                 375                 380                 


Tyr Lys Pro Ile Val Ala Ile Tyr Ser Thr Phe Leu Gln Arg Ala Tyr 
385                 390                 395                 400 


Asp Gln Val Leu His Asp Val Ala Ile Gln Lys Leu Pro Val Leu Phe 
                405                 410                 415     


Ala Ile Asp Arg Ala Gly Ile Val Gly Ala Asp Gly Gln Thr His Gln 
            420                 425                 430         


Gly Ala Phe Asp Leu Ser Tyr Leu Arg Cys Ile Pro Glu Met Val Ile 
        435                 440                 445             


Met Thr Pro Ser Asp Glu Asn Glu Cys Arg Gln Met Leu Tyr Thr Gly 
    450                 455                 460                 


Tyr His Tyr Asn Asp Gly Pro Ser Ala Val Arg Tyr Pro Arg Gly Asn 
465                 470                 475                 480 


Ala Val Gly Val Glu Leu Thr Pro Leu Glu Lys Leu Pro Ile Gly Lys 
                485                 490                 495     


Gly Ile Val Lys Arg Arg Gly Glu Lys Leu Ala Ile Leu Asn Phe Gly 
            500                 505                 510         


Thr Leu Met Pro Glu Ala Ala Lys Val Ala Glu Ser Leu Asn Ala Thr 
        515                 520                 525             


Leu Val Asp Met Arg Phe Val Lys Pro Leu Asp Glu Ala Leu Ile Leu 
    530                 535                 540                 


Glu Met Ala Ala Ser His Glu Ala Leu Val Thr Val Glu Glu Asn Ala 
545                 550                 555                 560 


Ile Met Gly Gly Ala Gly Ser Gly Val Asn Glu Val Leu Met Ala His 
                565                 570                 575     


Arg Lys Pro Val Pro Val Leu Asn Ile Gly Leu Pro Asp Phe Phe Ile 
            580                 585                 590         


Pro Gln Gly Thr Gln Glu Glu Met Arg Ala Glu Leu Gly Leu Asp Ala 
        595                 600                 605             


Ala Gly Met Glu Ala Lys Ile Lys Ala Trp Leu Ala 
    610                 615                 620 


<210>  33
<211>  398
<212>  PRT
<213>  Escherichia coli

<400>  33

Met Lys Gln Leu Thr Ile Leu Gly Ser Thr Gly Ser Ile Gly Cys Ser 
1               5                   10                  15      


Thr Leu Asp Val Val Arg His Asn Pro Glu His Phe Arg Val Val Ala 
            20                  25                  30          


Leu Val Ala Gly Lys Asn Val Thr Arg Met Val Glu Gln Cys Leu Glu 
        35                  40                  45              


Phe Ser Pro Arg Tyr Ala Val Met Asp Asp Glu Ala Ser Ala Lys Leu 
    50                  55                  60                  


Leu Lys Thr Met Leu Gln Gln Gln Gly Ser Arg Thr Glu Val Leu Ser 
65                  70                  75                  80  


Gly Gln Gln Ala Ala Cys Asp Met Ala Ala Leu Glu Asp Val Asp Gln 
                85                  90                  95      


Val Met Ala Ala Ile Val Gly Ala Ala Gly Leu Leu Pro Thr Leu Ala 
            100                 105                 110         


Ala Ile Arg Ala Gly Lys Thr Ile Leu Leu Ala Asn Lys Glu Ser Leu 
        115                 120                 125             


Val Thr Cys Gly Arg Leu Phe Met Asp Ala Val Lys Gln Ser Lys Ala 
    130                 135                 140                 


Gln Leu Leu Pro Val Asp Ser Glu His Asn Ala Ile Phe Gln Ser Leu 
145                 150                 155                 160 


Pro Gln Pro Ile Gln His Asn Leu Gly Tyr Ala Asp Leu Glu Gln Asn 
                165                 170                 175     


Gly Val Val Ser Ile Leu Leu Thr Gly Ser Gly Gly Pro Phe Arg Glu 
            180                 185                 190         


Thr Pro Leu Arg Asp Leu Ala Thr Met Thr Pro Asp Gln Ala Cys Arg 
        195                 200                 205             


His Pro Asn Trp Ser Met Gly Arg Lys Ile Ser Val Asp Ser Ala Thr 
    210                 215                 220                 


Met Met Asn Lys Gly Leu Glu Tyr Ile Glu Ala Arg Trp Leu Phe Asn 
225                 230                 235                 240 


Ala Ser Ala Ser Gln Met Glu Val Leu Ile His Pro Gln Ser Val Ile 
                245                 250                 255     


His Ser Met Val Arg Tyr Gln Asp Gly Ser Val Leu Ala Gln Leu Gly 
            260                 265                 270         


Glu Pro Asp Met Arg Thr Pro Ile Ala His Thr Met Ala Trp Pro Asn 
        275                 280                 285             


Arg Val Asn Ser Gly Val Lys Pro Leu Asp Phe Cys Lys Leu Ser Ala 
    290                 295                 300                 


Leu Thr Phe Ala Ala Pro Asp Tyr Asp Arg Tyr Pro Cys Leu Lys Leu 
305                 310                 315                 320 


Ala Met Glu Ala Phe Glu Gln Gly Gln Ala Ala Thr Thr Ala Leu Asn 
                325                 330                 335     


Ala Ala Asn Glu Ile Thr Val Ala Ala Phe Leu Ala Gln Gln Ile Arg 
            340                 345                 350         


Phe Thr Asp Ile Ala Ala Leu Asn Leu Ser Val Leu Glu Lys Met Asp 
        355                 360                 365             


Met Arg Glu Pro Gln Cys Val Asp Asp Val Leu Ser Val Asp Ala Asn 
    370                 375                 380                 


Ala Arg Glu Val Ala Arg Lys Glu Val Met Arg Leu Ala Ser 
385                 390                 395             


<210>  34
<211>  236
<212>  PRT
<213>  Escherichia coli

<400>  34

Met Ala Thr Thr His Leu Asp Val Cys Ala Val Val Pro Ala Ala Gly 
1               5                   10                  15      


Phe Gly Arg Arg Met Gln Thr Glu Cys Pro Lys Gln Tyr Leu Ser Ile 
            20                  25                  30          


Gly Asn Gln Thr Ile Leu Glu His Ser Val His Ala Leu Leu Ala His 
        35                  40                  45              


Pro Arg Val Lys Arg Val Val Ile Ala Ile Ser Pro Gly Asp Ser Arg 
    50                  55                  60                  


Phe Ala Gln Leu Pro Leu Ala Asn His Pro Arg Ile Thr Val Val Asp 
65                  70                  75                  80  


Gly Gly Glu Glu Arg Ala Asp Ser Val Leu Ala Gly Leu Lys Ala Ala 
                85                  90                  95      


Gly Asp Ala Gln Trp Val Leu Val His Asp Ala Ala Arg Pro Cys Leu 
            100                 105                 110         


His Gln Asp Asp Leu Ala Arg Leu Leu Ala Leu Ser Glu Thr Ser Arg 
        115                 120                 125             


Thr Gly Gly Ile Leu Ala Ala Pro Val Arg Asp Thr Met Lys Arg Ala 
    130                 135                 140                 


Glu Pro Gly Lys Asn Ala Ile Ala His Thr Val Asp Arg Asn Gly Leu 
145                 150                 155                 160 


Trp His Ala Leu Thr Pro Gln Phe Phe Pro Arg Glu Leu Leu His Asp 
                165                 170                 175     


Cys Leu Thr Arg Ala Leu Asn Glu Gly Ala Thr Ile Thr Asp Glu Ala 
            180                 185                 190         


Ser Ala Leu Glu Tyr Cys Gly Phe His Pro Gln Leu Val Glu Gly Arg 
        195                 200                 205             


Ala Asp Asn Ile Lys Val Thr Arg Pro Glu Asp Leu Ala Leu Ala Glu 
    210                 215                 220                 


Phe Tyr Leu Thr Arg Thr Ile His Gln Glu Asn Thr 
225                 230                 235     


<210>  35
<211>  283
<212>  PRT
<213>  Escherichia coli

<400>  35

Met Arg Thr Gln Trp Pro Ser Pro Ala Lys Leu Asn Leu Phe Leu Tyr 
1               5                   10                  15      


Ile Thr Gly Gln Arg Ala Asp Gly Tyr His Thr Leu Gln Thr Leu Phe 
            20                  25                  30          


Gln Phe Leu Asp Tyr Gly Asp Thr Ile Ser Ile Glu Leu Arg Asp Asp 
        35                  40                  45              


Gly Asp Ile Arg Leu Leu Thr Pro Val Glu Gly Val Glu His Glu Asp 
    50                  55                  60                  


Asn Leu Ile Val Arg Ala Ala Arg Leu Leu Met Lys Thr Ala Ala Asp 
65                  70                  75                  80  


Ser Gly Arg Leu Pro Thr Gly Ser Gly Ala Asn Ile Ser Ile Asp Lys 
                85                  90                  95      


Arg Leu Pro Met Gly Gly Gly Leu Gly Gly Gly Ser Ser Asn Ala Ala 
            100                 105                 110         


Thr Val Leu Val Ala Leu Asn His Leu Trp Gln Cys Gly Leu Ser Met 
        115                 120                 125             


Asp Glu Leu Ala Glu Met Gly Leu Thr Leu Gly Ala Asp Val Pro Val 
    130                 135                 140                 


Phe Val Arg Gly His Ala Ala Phe Ala Glu Gly Val Gly Glu Ile Leu 
145                 150                 155                 160 


Thr Pro Val Asp Pro Pro Glu Lys Trp Tyr Leu Val Ala His Pro Gly 
                165                 170                 175     


Val Ser Ile Pro Thr Pro Val Ile Phe Lys Asp Pro Glu Leu Pro Arg 
            180                 185                 190         


Asn Thr Pro Lys Arg Ser Ile Glu Thr Leu Leu Lys Cys Glu Phe Ser 
        195                 200                 205             


Asn Asp Cys Glu Val Ile Ala Arg Lys Arg Phe Arg Glu Val Asp Ala 
    210                 215                 220                 


Val Leu Ser Trp Leu Leu Glu Tyr Ala Pro Ser Arg Leu Thr Gly Thr 
225                 230                 235                 240 


Gly Ala Cys Val Phe Ala Glu Phe Asp Thr Glu Ser Glu Ala Arg Gln 
                245                 250                 255     


Val Leu Glu Gln Ala Pro Glu Trp Leu Asn Gly Phe Val Ala Lys Gly 
            260                 265                 270         


Ala Asn Leu Ser Pro Leu His Arg Ala Met Leu 
        275                 280             


<210>  36
<211>  159
<212>  PRT
<213>  Escherichia coli

<400>  36

Met Arg Ile Gly His Gly Phe Asp Val His Ala Phe Gly Gly Glu Gly 
1               5                   10                  15      


Pro Ile Ile Ile Gly Gly Val Arg Ile Pro Tyr Glu Lys Gly Leu Leu 
            20                  25                  30          


Ala His Ser Asp Gly Asp Val Val Leu His Ala Leu Thr Asp Ala Leu 
        35                  40                  45              


Leu Gly Ala Ala Ala Leu Gly Asp Ile Gly Lys Leu Phe Pro Asp Thr 
    50                  55                  60                  


Asp Pro Ala Phe Lys Gly Ala Asp Ser Arg Glu Leu Leu Arg Glu Ala 
65                  70                  75                  80  


Trp Arg Arg Ile Gln Ala Lys Gly Tyr Ala Leu Gly Asn Val Asp Val 
                85                  90                  95      


Thr Ile Ile Ala Gln Ala Pro Arg Met Leu Pro His Ile Pro Gln Met 
            100                 105                 110         


Arg Val Phe Ile Ala Glu Asp Leu Gly Cys His Met Asp Asp Val Asn 
        115                 120                 125             


Val Lys Ala Thr Thr Thr Glu Lys Leu Gly Phe Thr Gly Arg Gly Glu 
    130                 135                 140                 


Gly Ile Ala Cys Glu Ala Val Ala Leu Leu Ile Lys Ala Thr Lys 
145                 150                 155                 


<210>  37
<211>  372
<212>  PRT
<213>  Escherichia coli

<400>  37

Met His Asn Gln Ala Pro Ile Gln Arg Arg Lys Ser Thr Arg Ile Tyr 
1               5                   10                  15      


Val Gly Asn Val Pro Ile Gly Asp Gly Ala Pro Ile Ala Val Gln Ser 
            20                  25                  30          


Met Thr Asn Thr Arg Thr Thr Asp Val Glu Ala Thr Val Asn Gln Ile 
        35                  40                  45              


Lys Ala Leu Glu Arg Val Gly Ala Asp Ile Val Arg Val Ser Val Pro 
    50                  55                  60                  


Thr Met Asp Ala Ala Glu Ala Phe Lys Leu Ile Lys Gln Gln Val Asn 
65                  70                  75                  80  


Val Pro Leu Val Ala Asp Ile His Phe Asp Tyr Arg Ile Ala Leu Lys 
                85                  90                  95      


Val Ala Glu Tyr Gly Val Asp Cys Leu Arg Ile Asn Pro Gly Asn Ile 
            100                 105                 110         


Gly Asn Glu Glu Arg Ile Arg Met Val Val Asp Cys Ala Arg Asp Lys 
        115                 120                 125             


Asn Ile Pro Ile Arg Ile Gly Val Asn Ala Gly Ser Leu Glu Lys Asp 
    130                 135                 140                 


Leu Gln Glu Lys Tyr Gly Glu Pro Thr Pro Gln Ala Leu Leu Glu Ser 
145                 150                 155                 160 


Ala Met Arg His Val Asp His Leu Asp Arg Leu Asn Phe Asp Gln Phe 
                165                 170                 175     


Lys Val Ser Val Lys Ala Ser Asp Val Phe Leu Ala Val Glu Ser Tyr 
            180                 185                 190         


Arg Leu Leu Ala Lys Gln Ile Asp Gln Pro Leu His Leu Gly Ile Thr 
        195                 200                 205             


Glu Ala Gly Gly Ala Arg Ser Gly Ala Val Lys Ser Ala Ile Gly Leu 
    210                 215                 220                 


Gly Leu Leu Leu Ser Glu Gly Ile Gly Asp Thr Leu Arg Val Ser Leu 
225                 230                 235                 240 


Ala Ala Asp Pro Val Glu Glu Ile Lys Val Gly Phe Asp Ile Leu Lys 
                245                 250                 255     


Ser Leu Arg Ile Arg Ser Arg Gly Ile Asn Phe Ile Ala Cys Pro Thr 
            260                 265                 270         


Cys Ser Arg Gln Glu Phe Asp Val Ile Gly Thr Val Asn Ala Leu Glu 
        275                 280                 285             


Gln Arg Leu Glu Asp Ile Ile Thr Pro Met Asp Val Ser Ile Ile Gly 
    290                 295                 300                 


Cys Val Val Asn Gly Pro Gly Glu Ala Leu Val Ser Thr Leu Gly Val 
305                 310                 315                 320 


Thr Gly Gly Asn Lys Lys Ser Gly Leu Tyr Glu Asp Gly Val Arg Lys 
                325                 330                 335     


Asp Arg Leu Asp Asn Asn Asp Met Ile Asp Gln Leu Glu Ala Arg Ile 
            340                 345                 350         


Arg Ala Lys Ala Ser Gln Leu Asp Glu Ala Arg Arg Ile Asp Val Gln 
        355                 360                 365             


Gln Val Glu Lys 
    370         


<210>  38
<211>  316
<212>  PRT
<213>  Escherichia coli

<400>  38

Met Gln Ile Leu Leu Ala Asn Pro Arg Gly Phe Cys Ala Gly Val Asp 
1               5                   10                  15      


Arg Ala Ile Ser Ile Val Glu Asn Ala Leu Ala Ile Tyr Gly Ala Pro 
            20                  25                  30          


Ile Tyr Val Arg His Glu Val Val His Asn Arg Tyr Val Val Asp Ser 
        35                  40                  45              


Leu Arg Glu Arg Gly Ala Ile Phe Ile Glu Gln Ile Ser Glu Val Pro 
    50                  55                  60                  


Asp Gly Ala Ile Leu Ile Phe Ser Ala His Gly Val Ser Gln Ala Val 
65                  70                  75                  80  


Arg Asn Glu Ala Lys Ser Arg Asp Leu Thr Val Phe Asp Ala Thr Cys 
                85                  90                  95      


Pro Leu Val Thr Lys Val His Met Glu Val Ala Arg Ala Ser Arg Arg 
            100                 105                 110         


Gly Glu Glu Ser Ile Leu Ile Gly His Ala Gly His Pro Glu Val Glu 
        115                 120                 125             


Gly Thr Met Gly Gln Tyr Ser Asn Pro Glu Gly Gly Met Tyr Leu Val 
    130                 135                 140                 


Glu Ser Pro Asp Asp Val Trp Lys Leu Thr Val Lys Asn Glu Glu Lys 
145                 150                 155                 160 


Leu Ser Phe Met Thr Gln Thr Thr Leu Ser Val Asp Asp Thr Ser Asp 
                165                 170                 175     


Val Ile Asp Ala Leu Arg Lys Arg Phe Pro Lys Ile Val Gly Pro Arg 
            180                 185                 190         


Lys Asp Asp Ile Cys Tyr Ala Thr Thr Asn Arg Gln Glu Ala Val Arg 
        195                 200                 205             


Ala Leu Ala Glu Gln Ala Glu Val Val Leu Val Val Gly Ser Lys Asn 
    210                 215                 220                 


Ser Ser Asn Ser Asn Arg Leu Ala Glu Leu Ala Gln Arg Met Gly Lys 
225                 230                 235                 240 


Arg Ala Phe Leu Ile Asp Asp Ala Thr Asp Ile Gln Glu Glu Trp Val 
                245                 250                 255     


Lys Glu Ala Lys Cys Val Gly Val Thr Ala Gly Ala Ser Ala Pro Asp 
            260                 265                 270         


Ile Leu Val Gln Asn Val Val Ala Arg Leu Gln Gln Leu Gly Gly Gly 
        275                 280                 285             


Glu Ala Ile Pro Leu Glu Gly Arg Glu Glu Asn Ile Val Phe Glu Val 
    290                 295                 300                 


Pro Lys Glu Leu Arg Val Asp Ile Arg Glu Val Asp 
305                 310                 315     


<210>  39
<211>  182
<212>  PRT
<213>  Escherichia coli

<400>  39

Met Gln Thr Glu His Val Ile Leu Leu Asn Ala Gln Gly Val Pro Thr 
1               5                   10                  15      


Gly Thr Leu Glu Lys Tyr Ala Ala His Thr Ala Asp Thr Arg Leu His 
            20                  25                  30          


Leu Ala Phe Ser Ser Trp Leu Phe Asn Ala Lys Gly Gln Leu Leu Val 
        35                  40                  45              


Thr Arg Arg Ala Leu Ser Lys Lys Ala Trp Pro Gly Val Trp Thr Asn 
    50                  55                  60                  


Ser Val Cys Gly His Pro Gln Leu Gly Glu Ser Asn Glu Asp Ala Val 
65                  70                  75                  80  


Ile Arg Arg Cys Arg Tyr Glu Leu Gly Val Glu Ile Thr Pro Pro Glu 
                85                  90                  95      


Ser Ile Tyr Pro Asp Phe Arg Tyr Arg Ala Thr Asp Pro Ser Gly Ile 
            100                 105                 110         


Val Glu Asn Glu Val Cys Pro Val Phe Ala Ala Arg Thr Thr Ser Ala 
        115                 120                 125             


Leu Gln Ile Asn Asp Asp Glu Val Met Asp Tyr Gln Trp Cys Asp Leu 
    130                 135                 140                 


Ala Asp Val Leu His Gly Ile Asp Ala Thr Pro Trp Ala Phe Ser Pro 
145                 150                 155                 160 


Trp Met Val Met Gln Ala Thr Asn Arg Glu Ala Arg Lys Arg Leu Ser 
                165                 170                 175     


Ala Phe Thr Gln Leu Lys 
            180         


<210>  40
<211>  299
<212>  PRT
<213>  Escherichia coli

<400>  40

Met Asp Phe Pro Gln Gln Leu Glu Ala Cys Val Lys Gln Ala Asn Gln 
1               5                   10                  15      


Ala Leu Ser Arg Phe Ile Ala Pro Leu Pro Phe Gln Asn Thr Pro Val 
            20                  25                  30          


Val Glu Thr Met Gln Tyr Gly Ala Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly His Met Phe Gly Val Ser Thr Asn 
    50                  55                  60                  


Thr Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr Ser 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Leu Pro Thr Cys His Val Lys Phe Gly Glu Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ser Asp Ala 
        115                 120                 125             


Asp Met Pro Glu Val Ser Asp Arg Asp Arg Ile Ser Met Ile Ser Glu 
    130                 135                 140                 


Leu Ala Ser Ala Ser Gly Ile Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Asp Ala Glu Gly Lys His Val Pro Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Leu 
            180                 185                 190         


Gly Ala Leu Ser Ala Gly Asp Lys Gly Arg Arg Ala Leu Pro Val Leu 
        195                 200                 205             


Asp Lys Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Arg Lys Lys Ala Arg Asp Leu Ile Asp Asp Ala Arg Gln 
            260                 265                 270         


Ser Leu Lys Gln Leu Ala Glu Gln Ser Leu Asp Thr Ser Ala Leu Glu 
        275                 280                 285             


Ala Leu Ala Asp Tyr Ile Ile Gln Arg Asn Lys 
    290                 295                 


<210>  41
<211>  1083
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  41
atgaagctac taaccttccc aggtcaaggg acctccatct ccatttcgat attaaaagcg       60

ataataagaa acaaatcaag agaattccaa acaatactga gtcagaacgg caaggaatca      120

aatgatctat tgcagtacat cttccagaac ccttccagcc ccggaagcat tgcagtctgc      180

tccaaccttt tctatcaatt gtaccagata ctctcgaatc cttctgatcc tcaagatcaa      240

gcaccaaaaa atatgactaa gatcgattcc cccgacaaga aagacaatga acaatgttac      300

cttttgggtc actcgctagg cgagttaaca tgtctgagtg ttaattcact gttttcgtta      360

aaggatcttt ttgatattgc taattttaga aataagttaa tggtaacatc tactgaaaag      420

tacttagtag cccacaatat caacagatcc aacaaatttg aaatgtgggc actctcttct      480

ccgagggcca cagatttacc gcaagaagtg caaaaactac taaattcccc taatttatta      540

tcatcttcac aaaataccat ttctgtagca aatgcaaatt cagtaaagca atgtgtagtc      600

accggtctgg ttgatgattt agagtcctta agaacagaat tgaacttaag gttcccgcgt      660

ttaagaatta cagaattaac taacccatac aacatcccct tccataatag cactgtgttg      720

aggcccgttc aggaaccact ctatgactac atttgggata tattaaagaa aaacggaact      780

cacacgttga tggagttgaa ccatccaata atagctaact tagatggtaa tatatcttac      840

tatattcatc atgccctaga tagattcgtt aagtgttcaa gcaggactgt gcaattcacc      900

atgtgttatg ataccataaa ctctggaacc ccagtggaaa ttgataagag tatttgcttt      960

ggcccgggca atgtgattta taaccttatt cggagaaatt gtccccaagt ggacactata     1020

gaatacacct ctttagcaac tatagacgct tatcacaagg cggcagagga gaacaaagat     1080

tga                                                                   1083


<210>  42
<211>  360
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  42

Met Lys Leu Leu Thr Phe Pro Gly Gln Gly Thr Ser Ile Ser Ile Ser 
1               5                   10                  15      


Ile Leu Lys Ala Ile Ile Arg Asn Lys Ser Arg Glu Phe Gln Thr Ile 
            20                  25                  30          


Leu Ser Gln Asn Gly Lys Glu Ser Asn Asp Leu Leu Gln Tyr Ile Phe 
        35                  40                  45              


Gln Asn Pro Ser Ser Pro Gly Ser Ile Ala Val Cys Ser Asn Leu Phe 
    50                  55                  60                  


Tyr Gln Leu Tyr Gln Ile Leu Ser Asn Pro Ser Asp Pro Gln Asp Gln 
65                  70                  75                  80  


Ala Pro Lys Asn Met Thr Lys Ile Asp Ser Pro Asp Lys Lys Asp Asn 
                85                  90                  95      


Glu Gln Cys Tyr Leu Leu Gly His Ser Leu Gly Glu Leu Thr Cys Leu 
            100                 105                 110         


Ser Val Asn Ser Leu Phe Ser Leu Lys Asp Leu Phe Asp Ile Ala Asn 
        115                 120                 125             


Phe Arg Asn Lys Leu Met Val Thr Ser Thr Glu Lys Tyr Leu Val Ala 
    130                 135                 140                 


His Asn Ile Asn Arg Ser Asn Lys Phe Glu Met Trp Ala Leu Ser Ser 
145                 150                 155                 160 


Pro Arg Ala Thr Asp Leu Pro Gln Glu Val Gln Lys Leu Leu Asn Ser 
                165                 170                 175     


Pro Asn Leu Leu Ser Ser Ser Gln Asn Thr Ile Ser Val Ala Asn Ala 
            180                 185                 190         


Asn Ser Val Lys Gln Cys Val Val Thr Gly Leu Val Asp Asp Leu Glu 
        195                 200                 205             


Ser Leu Arg Thr Glu Leu Asn Leu Arg Phe Pro Arg Leu Arg Ile Thr 
    210                 215                 220                 


Glu Leu Thr Asn Pro Tyr Asn Ile Pro Phe His Asn Ser Thr Val Leu 
225                 230                 235                 240 


Arg Pro Val Gln Glu Pro Leu Tyr Asp Tyr Ile Trp Asp Ile Leu Lys 
                245                 250                 255     


Lys Asn Gly Thr His Thr Leu Met Glu Leu Asn His Pro Ile Ile Ala 
            260                 265                 270         


Asn Leu Asp Gly Asn Ile Ser Tyr Tyr Ile His His Ala Leu Asp Arg 
        275                 280                 285             


Phe Val Lys Cys Ser Ser Arg Thr Val Gln Phe Thr Met Cys Tyr Asp 
    290                 295                 300                 


Thr Ile Asn Ser Gly Thr Pro Val Glu Ile Asp Lys Ser Ile Cys Phe 
305                 310                 315                 320 


Gly Pro Gly Asn Val Ile Tyr Asn Leu Ile Arg Arg Asn Cys Pro Gln 
                325                 330                 335     


Val Asp Thr Ile Glu Tyr Thr Ser Leu Ala Thr Ile Asp Ala Tyr His 
            340                 345                 350         


Lys Ala Ala Glu Glu Asn Lys Asp 
        355                 360 


<210>  43
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial beta-ketothiolase (BktB) nucleotide sequence

<400>  43
atgactagag aagttgtcgt cgtttccggt gtccgtaccg ctatcggtac tttcggtggt       60

tccttaaagg atgttgctcc tgctgaattg ggtgctttag ttgttagaga agctttggcc      120

agagcccaag tctccggtga cgacgttggt cacgtcgttt tcggtaacgt catccaaact      180

gaaccacgtg acatgtactt gggtagagtc gccgctgtta acggtggtgt caccatcaac      240

gctcctgcct taactgttaa cagattatgt ggttccggtt tacaagctat tgtctctgcc      300

gcccaaacta tcttgttggg tgatactgac gttgctattg gtggtggtgc tgaatctatg      360

tctagagctc catacttggc tccagctgcc cgttggggtg ctagaatggg tgacgccggt      420

ttggtcgata tgatgttggg tgccttgcat gatcctttcc acagaatcca catgggtgtt      480

accgctgaaa acgttgctaa ggaatacgat atctctagag ctcaacaaga tgaagccgct      540

ttagaatctc acagacgtgc ctccgccgct attaaggctg gttacttcaa ggaccaaatt      600

gttccagttg tctctaaggg tcgtaaaggt gatgttacct ttgatactga cgaacacgtt      660

agacacgacg ccactattga cgatatgact aaattaagac cagtctttgt taaggagaat      720

ggtaccgtta ctgctggtaa cgcttctggt ttgaacgatg ccgccgctgc cgttgttatg      780

atggaaagag ctgaagccga aagacgtggt ttaaagccat tggccagatt agtctcctac      840

ggtcacgctg gtgtcgaccc aaaggctatg ggtatcggtc cagttcctgc tactaagatt      900

gctttagaaa gagctggttt gcaagtttct gacttggacg tcatcgaagc caacgaagcc      960

ttcgctgctc aagcttgtgc tgtcaccaag gctttgggtt tggatccagc taaagttaac     1020

cctaatggtt ctggtatttc cttgggtcac ccaatcggtg ctaccggtgc tttaatcact     1080

gttaaagcct tacacgaatt gaacagagtt caaggtagat acgctttggt cactatgtgc     1140

atcggtggtg gtcaaggtat cgctgctatc ttcgaaagaa tcggatccta a              1191


<210>  44
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered beta-ketothiolase (BktB)

<400>  44

Met Thr Arg Glu Val Val Val Val Ser Gly Val Arg Thr Ala Ile Gly 
1               5                   10                  15      


Thr Phe Gly Gly Ser Leu Lys Asp Val Ala Pro Ala Glu Leu Gly Ala 
            20                  25                  30          


Leu Val Val Arg Glu Ala Leu Ala Arg Ala Gln Val Ser Gly Asp Asp 
        35                  40                  45              


Val Gly His Val Val Phe Gly Asn Val Ile Gln Thr Glu Pro Arg Asp 
    50                  55                  60                  


Met Tyr Leu Gly Arg Val Ala Ala Val Asn Gly Gly Val Thr Ile Asn 
65                  70                  75                  80  


Ala Pro Ala Leu Thr Val Asn Arg Leu Cys Gly Ser Gly Leu Gln Ala 
                85                  90                  95      


Ile Val Ser Ala Ala Gln Thr Ile Leu Leu Gly Asp Thr Asp Val Ala 
            100                 105                 110         


Ile Gly Gly Gly Ala Glu Ser Met Ser Arg Ala Pro Tyr Leu Ala Pro 
        115                 120                 125             


Ala Ala Arg Trp Gly Ala Arg Met Gly Asp Ala Gly Leu Val Asp Met 
    130                 135                 140                 


Met Leu Gly Ala Leu His Asp Pro Phe His Arg Ile His Met Gly Val 
145                 150                 155                 160 


Thr Ala Glu Asn Val Ala Lys Glu Tyr Asp Ile Ser Arg Ala Gln Gln 
                165                 170                 175     


Asp Glu Ala Ala Leu Glu Ser His Arg Arg Ala Ser Ala Ala Ile Lys 
            180                 185                 190         


Ala Gly Tyr Phe Lys Asp Gln Ile Val Pro Val Val Ser Lys Gly Arg 
        195                 200                 205             


Lys Gly Asp Val Thr Phe Asp Thr Asp Glu His Val Arg His Asp Ala 
    210                 215                 220                 


Thr Ile Asp Asp Met Thr Lys Leu Arg Pro Val Phe Val Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Ala Ala Ala 
                245                 250                 255     


Ala Val Val Met Met Glu Arg Ala Glu Ala Glu Arg Arg Gly Leu Lys 
            260                 265                 270         


Pro Leu Ala Arg Leu Val Ser Tyr Gly His Ala Gly Val Asp Pro Lys 
        275                 280                 285             


Ala Met Gly Ile Gly Pro Val Pro Ala Thr Lys Ile Ala Leu Glu Arg 
    290                 295                 300                 


Ala Gly Leu Gln Val Ser Asp Leu Asp Val Ile Glu Ala Asn Glu Ala 
305                 310                 315                 320 


Phe Ala Ala Gln Ala Cys Ala Val Thr Lys Ala Leu Gly Leu Asp Pro 
                325                 330                 335     


Ala Lys Val Asn Pro Asn Gly Ser Gly Ile Ser Leu Gly His Pro Ile 
            340                 345                 350         


Gly Ala Thr Gly Ala Leu Ile Thr Val Lys Ala Leu His Glu Leu Asn 
        355                 360                 365             


Arg Val Gln Gly Arg Tyr Ala Leu Val Thr Met Cys Ile Gly Gly Gly 
    370                 375                 380                 


Gln Gly Ile Ala Ala Ile Phe Glu Arg Ile Gly Ser 
385                 390                 395     


<210>  45
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial PaaH1: 3-hydroxyacyl-CoA dehydrogenase nucleotide 
       sequence

<400>  45
atgtccatca gaactgtcgg tattgttggt gctggtacta tgggtaacgg tattgctcaa       60

gcctgtgctg tcgtcggttt gaacgtcgtc atggtcgaca tttctgacgc tgctgttcaa      120

aagggtgttg ctactgtcgc ttcctctttg gacagattaa ttaagaagga aaagttgacc      180

gaagccgaca aggcctctgc cttggccaga attaagggtt ccacttctta tgacgacttg      240

aaagctaccg acattgttat cgaagctgct actgaaaact acgatttgaa agttaagatc      300

ttgaagcaaa ttgatggtat cgtcggtgag aacgtcatta ttgcttctaa cacttcctcc      360

atttctatca ctaaattagc cgccgtcacc tctagagccg acagatttat cggtatgcac      420

ttctttaatc cagttccagt catggctttg gtcgaattaa ttagaggttt gcaaacctcc      480

gacaccaccc acgccgccgt tgaagctttg tctaagcaat tgggtaagta cccaatcacc      540

gttaaaaatt ccccaggttt cgttgtcaac cgtattttgt gcccaatgat caatgaagct      600

ttctgtgtct tgggtgaggg tttggcctcc ccagaagaaa tcgatgaagg tatgaagtta      660

ggttgtaacc accctattgg tcctttagcc ttggccgaca tgatcggttt agacactatg      720

ttggccgtta tggaagtctt gtacactgaa ttcgctgacc caaagtacag accagctatg      780

ttaatgagag aaatggttgc tgccggttat ttgggtagaa agactggtcg tggtgtttat      840

gtctactcta aagggatc                                                    858


<210>  46
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered PaaH1: 3-hydroxyacyl-CoA dehydrogenase

<400>  46

Met Ser Ile Arg Thr Val Gly Ile Val Gly Ala Gly Thr Met Gly Asn 
1               5                   10                  15      


Gly Ile Ala Gln Ala Cys Ala Val Val Gly Leu Asn Val Val Met Val 
            20                  25                  30          


Asp Ile Ser Asp Ala Ala Val Gln Lys Gly Val Ala Thr Val Ala Ser 
        35                  40                  45              


Ser Leu Asp Arg Leu Ile Lys Lys Glu Lys Leu Thr Glu Ala Asp Lys 
    50                  55                  60                  


Ala Ser Ala Leu Ala Arg Ile Lys Gly Ser Thr Ser Tyr Asp Asp Leu 
65                  70                  75                  80  


Lys Ala Thr Asp Ile Val Ile Glu Ala Ala Thr Glu Asn Tyr Asp Leu 
                85                  90                  95      


Lys Val Lys Ile Leu Lys Gln Ile Asp Gly Ile Val Gly Glu Asn Val 
            100                 105                 110         


Ile Ile Ala Ser Asn Thr Ser Ser Ile Ser Ile Thr Lys Leu Ala Ala 
        115                 120                 125             


Val Thr Ser Arg Ala Asp Arg Phe Ile Gly Met His Phe Phe Asn Pro 
    130                 135                 140                 


Val Pro Val Met Ala Leu Val Glu Leu Ile Arg Gly Leu Gln Thr Ser 
145                 150                 155                 160 


Asp Thr Thr His Ala Ala Val Glu Ala Leu Ser Lys Gln Leu Gly Lys 
                165                 170                 175     


Tyr Pro Ile Thr Val Lys Asn Ser Pro Gly Phe Val Val Asn Arg Ile 
            180                 185                 190         


Leu Cys Pro Met Ile Asn Glu Ala Phe Cys Val Leu Gly Glu Gly Leu 
        195                 200                 205             


Ala Ser Pro Glu Glu Ile Asp Glu Gly Met Lys Leu Gly Cys Asn His 
    210                 215                 220                 


Pro Ile Gly Pro Leu Ala Leu Ala Asp Met Ile Gly Leu Asp Thr Met 
225                 230                 235                 240 


Leu Ala Val Met Glu Val Leu Tyr Thr Glu Phe Ala Asp Pro Lys Tyr 
                245                 250                 255     


Arg Pro Ala Met Leu Met Arg Glu Met Val Ala Ala Gly Tyr Leu Gly 
            260                 265                 270         


Arg Lys Thr Gly Arg Gly Val Tyr Val Tyr Ser Lys Gly Ile 
        275                 280                 285     


<210>  47
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial crotonase (Crt) nucleotide sequence

<400>  47
atggaattga acaacgttat tttggaaaag gaaggtaagg tcgctgtcgt tactatcaac       60

agaccaaagg ctttaaacgc tttgaactct gacaccttga aagaaatgga ttatgttatc      120

ggtgaaatcg aaaatgactc tgaagttttg gccgttatct tgactggtgc tggtgaaaaa      180

tctttcgttg ctggtgctga catttctgaa atgaaggaga tgaataccat tgaaggtaga      240

aagttcggta tcttgggtaa caaggttttt agaagattgg aattgttgga aaaaccagtc      300

atcgctgctg ttaacggttt cgctttaggt ggtggttgtg aaatcgctat gtcctgtgac      360

attcgtatcg cctcctccaa tgctagattc ggtcaaccag aagttggttt aggtattact      420

ccaggtttcg gtggtaccca aagattgtct agattggtcg gtatgggtat ggctaagcaa      480

ttaattttca ctgctcaaaa cattaaggct gatgaagcct tacgtattgg tttggtcaac      540

aaggtcgttg aaccatctga attgatgaat accgctaagg aaattgctaa caaaattgtt      600

tctaatgccc cagttgctgt caagttgtcc aagcaagcta ttaacagagg tatgcaatgt      660

gatattgaca ctgctttggc tttcgaatcc gaagcttttg gtgaatgttt ttctaccgaa      720

gatcaaaagg atgctatgac cgctttcatc gagaagagaa agatcgaagg tttcaaaaac      780

agaggatcct aa                                                          792


<210>  48
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered crotonase (Crt)

<400>  48

Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val 
1               5                   10                  15      


Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr 
            20                  25                  30          


Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu 
        35                  40                  45              


Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala 
    50                  55                  60                  


Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg 
65                  70                  75                  80  


Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu 
                85                  90                  95      


Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly 
            100                 105                 110         


Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala 
        115                 120                 125             


Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly 
    130                 135                 140                 


Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln 
145                 150                 155                 160 


Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile 
                165                 170                 175     


Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala 
            180                 185                 190         


Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys 
        195                 200                 205             


Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr 
    210                 215                 220                 


Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu 
225                 230                 235                 240 


Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu 
                245                 250                 255     


Gly Phe Lys Asn Arg Gly Ser 
            260             


<210>  49
<211>  1200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Ter: trans-2-enoyl-CoA reductase nucleotide sequence

<400>  49
atgattgtca aaccaatggt tcgtaacaac atttgtttaa atgcccaccc acaaggttgt       60

aagaagggtg ttgaagatca aatcgaatac actaaaaaga gaattaccgc tgaagttaaa      120

gctggtgcta aggccccaaa gaacgttttg gttttgggtt gttccaacgg ttacggtttg      180

gcctccagaa ttactgctgc ttttggttac ggtgccgcta ccatcggtgt ctctttcgaa      240

aaggccggtt ccgaaactaa gtacggtact ccaggttggt acaataactt ggctttcgat      300

gaagctgcta agagagaagg tttgtattcc gttactattg acggtgatgc cttttctgac      360

gaaatcaaag ctcaagtcat cgaagaagcc aaaaagaaag gtatcaagtt cgatttgatt      420

gtctactctt tagcctctcc tgttagaact gatccagata ctggtattat gcacaaatcc      480

gttttgaagc cattcggtaa gaccttcact ggtaaaactg tcgatccttt cactggtgaa      540

ttaaaggaaa tctctgctga acctgccaac gacgaagaag ctgctgccac tgttaaggtt      600

atgggtggtg aagactggga aagatggatc aagcaattat ctaaggaagg tttgttggaa      660

gaaggttgta tcaccttggc ttactcttac atcggtccag aagctaccca agctttgtac      720

agaaagggta ccattggtaa ggctaaagaa cacttggagg ctactgctca tagattgaac      780

aaggaaaatc catccatcag agcctttgtt tccgtcaata aaggtttggt cactagagcc      840

tctgccgtca ttccagttat ccctttatac ttggcttctt tgtttaaagt catgaaggaa      900

aagggtaacc atgaaggttg tatcgaacaa atcactcgtt tgtacgctga acgtttatac      960

agaaaggacg gtaccatccc tgtcgatgaa gaaaacagaa tcagaatcga cgattgggaa     1020

ttggaagaag atgttcaaaa agccgtttcc gccttgatgg aaaaggtcac cggtgaaaat     1080

gccgaatcct tgactgactt agctggttac agacatgact ttttagcttc taatggtttc     1140

gatgttgaag gtattaacta tgaggctgaa gtcgaaagat ttgacagaat cggatcctaa     1200


<210>  50
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Ter: trans-2-enoyl-CoA reductase

<400>  50

Met Ile Val Lys Pro Met Val Arg Asn Asn Ile Cys Leu Asn Ala His 
1               5                   10                  15      


Pro Gln Gly Cys Lys Lys Gly Val Glu Asp Gln Ile Glu Tyr Thr Lys 
            20                  25                  30          


Lys Arg Ile Thr Ala Glu Val Lys Ala Gly Ala Lys Ala Pro Lys Asn 
        35                  40                  45              


Val Leu Val Leu Gly Cys Ser Asn Gly Tyr Gly Leu Ala Ser Arg Ile 
    50                  55                  60                  


Thr Ala Ala Phe Gly Tyr Gly Ala Ala Thr Ile Gly Val Ser Phe Glu 
65                  70                  75                  80  


Lys Ala Gly Ser Glu Thr Lys Tyr Gly Thr Pro Gly Trp Tyr Asn Asn 
                85                  90                  95      


Leu Ala Phe Asp Glu Ala Ala Lys Arg Glu Gly Leu Tyr Ser Val Thr 
            100                 105                 110         


Ile Asp Gly Asp Ala Phe Ser Asp Glu Ile Lys Ala Gln Val Ile Glu 
        115                 120                 125             


Glu Ala Lys Lys Lys Gly Ile Lys Phe Asp Leu Ile Val Tyr Ser Leu 
    130                 135                 140                 


Ala Ser Pro Val Arg Thr Asp Pro Asp Thr Gly Ile Met His Lys Ser 
145                 150                 155                 160 


Val Leu Lys Pro Phe Gly Lys Thr Phe Thr Gly Lys Thr Val Asp Pro 
                165                 170                 175     


Phe Thr Gly Glu Leu Lys Glu Ile Ser Ala Glu Pro Ala Asn Asp Glu 
            180                 185                 190         


Glu Ala Ala Ala Thr Val Lys Val Met Gly Gly Glu Asp Trp Glu Arg 
        195                 200                 205             


Trp Ile Lys Gln Leu Ser Lys Glu Gly Leu Leu Glu Glu Gly Cys Ile 
    210                 215                 220                 


Thr Leu Ala Tyr Ser Tyr Ile Gly Pro Glu Ala Thr Gln Ala Leu Tyr 
225                 230                 235                 240 


Arg Lys Gly Thr Ile Gly Lys Ala Lys Glu His Leu Glu Ala Thr Ala 
                245                 250                 255     


His Arg Leu Asn Lys Glu Asn Pro Ser Ile Arg Ala Phe Val Ser Val 
            260                 265                 270         


Asn Lys Gly Leu Val Thr Arg Ala Ser Ala Val Ile Pro Val Ile Pro 
        275                 280                 285             


Leu Tyr Leu Ala Ser Leu Phe Lys Val Met Lys Glu Lys Gly Asn His 
    290                 295                 300                 


Glu Gly Cys Ile Glu Gln Ile Thr Arg Leu Tyr Ala Glu Arg Leu Tyr 
305                 310                 315                 320 


Arg Lys Asp Gly Thr Ile Pro Val Asp Glu Glu Asn Arg Ile Arg Ile 
                325                 330                 335     


Asp Asp Trp Glu Leu Glu Glu Asp Val Gln Lys Ala Val Ser Ala Leu 
            340                 345                 350         


Met Glu Lys Val Thr Gly Glu Asn Ala Glu Ser Leu Thr Asp Leu Ala 
        355                 360                 365             


Gly Tyr Arg His Asp Phe Leu Ala Ser Asn Gly Phe Asp Val Glu Gly 
    370                 375                 380                 


Ile Asn Tyr Glu Ala Glu Val Glu Arg Phe Asp Arg Ile Gly Ser 
385                 390                 395                 


<210>  51
<211>  812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (tHMG1)

<400>  51
atggcgcgtg accaattggt gaaaactgaa gtcaccaaga agtcttttac tgctcctgta       60

caaaaggctt ctacaccagt tttaaccaat aaaacagtca tttctggatc gaaagtcaaa      120

agtttatcat ctgcgcaatc gagctcatca ggaccttcat catctagtga ggaagatgat      180

tcccgcgata ttgaaagctt ggataagaaa atacgtcctt tagaagaatt agaagcatta      240

ttaagtagtg gaaatacaaa acaattgaag aacaaagagg tcgctgcctt ggttattcac      300

ggtaagttac ctttgtacgc tttggagaaa aaattaggtg atactacgag agcggttgcg      360

gtacgtagga aggctctttc aattttggca gaagctcctg tattagcatc tgatcgttta      420

ccatataaaa attatgacta cgaccgcgta tttggcgctt gttgtgaaaa tgttataggt      480

tacatgcctt tgcccgttgg tgttataggc cccttggtta tcgatggtac atcttatcat      540

ataccaatgg caactacaga gggttgtttg gtagcttctg ccatgcgtgg ctgtaaggca      600

atcaatgctg gcggtggtgc aacaactgtt ttaactaagg atggtatgac aagaggccca      660

gtagtccgtt tcccaacttt gaaaagatct ggtgcctgta agatatggtt agactcagaa      720

gagggacaaa acgcaattaa aaaagctttt aactctacat caagatttgc acgtctgcaa      780

catattcaaa cttgtctagc aggagatttg tt                                    812


<210>  52
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (tHMG1)

<400>  52

Met Ala Arg Asp Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe 
1               5                   10                  15      


Thr Ala Pro Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr 
            20                  25                  30          


Val Ile Ser Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser 
        35                  40                  45              


Ser Ser Gly Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile 
    50                  55                  60                  


Glu Ser Leu Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala 
                85                  90                  95      


Leu Val Ile His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu 
            100                 105                 110         


Gly Asp Thr Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile 
        115                 120                 125             


Leu Ala Glu Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn 
    130                 135                 140                 


Tyr Asp Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly 
145                 150                 155                 160 


Tyr Met Pro Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly 
                165                 170                 175     


Thr Ser Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala 
            180                 185                 190         


Ser Ala Met Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr 
        195                 200                 205             


Thr Val Leu Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe 
    210                 215                 220                 


Pro Thr Leu Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu 
225                 230                 235                 240 


Glu Gly Gln Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe 
                245                 250                 255     


Ala Arg Leu Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu 
            260                 265                 270 


<210>  53
<211>  2412
<212>  DNA
<213>  Enterococcus sp.

<400>  53
atgaagactg tcgttatcat agatgccttg agaacaccaa tcggtaaata caaaggttca       60

ttatcccaag tttccgccgt tgacttaggt actcatgtta ctacacaatt gttgaagaga      120

cactccacaa tcagtgaaga aatcgatcaa gtcatattcg gtaacgtatt gcaagctggt      180

aatggtcaaa acccagccag acaaatagct atcaattctg gtttatcaca tgaaattcct      240

gctatgacag taaacgaagt ttgtggttca ggcatgaaag cagtcatttt ggccaagcaa      300

ttgatacaat taggtgaagc agaagtttta atcgccggtg gtatagaaaa catgagtcaa      360

gctccaaaat tgcaaagatt caattacgaa actgaatctt acgatgcacc tttctcttcg      420

atgatgtatg atggtttgac tgacgctttt tctggtcaag caatgggttt aacagctgaa      480

aatgtcgcag aaaagtacca tgtaaccaga gaagaacaag atcaattttc cgttcacagt      540

caattaaaag ctgcacaagc acaagccgaa ggtattttcg ccgacgaaat agctccattg      600

gaagtttctg gtacattagt cgaaaaggat gaaggtatta gacctaactc cagtgttgaa      660

aaattgggta ctttgaagac agtattcaag gaagacggta cagttaccgc tggtaatgcc      720

tctaccatta acgatggtgc tagtgcattg attatagctt ctcaagaata tgccgaagct      780

catggtttgc catacttagc tatcattaga gatagtgtag aagttggtat tgacccagca      840

tacatgggta tctctcctat aaaagcaatc caaaagttgt tagccagaaa ccaattgacc      900

actgaagaaa ttgatttgta cgaaattaac gaagcatttg ccgctacatc aatcgttgtc      960

caaagagaat tggcattgcc agaagaaaag gttaacatct atggtggtgg tatctccttg     1020

ggtcacgcta taggtgcaac cggtgccaga ttgttgactt ccttaagtta ccaattgaac     1080

caaaaggaaa agaaatacgg tgttgcttct ttatgcattg gtggtggttt gggtttagca     1140

atgttgttag aaagaccaca acaaaagaaa aattctagat tctaccaaat gtcccctgaa     1200

gaaagattgg cctcattgtt aaatgaaggt caaatttccg cagatactaa gaaagaattt     1260

gaaaacaccg ctttatcttc acaaatcgca aaccatatga tcgaaaacca aatctctgaa     1320

acagaagttc caatgggtgt cggtttgcac ttaactgtcg atgaaacaga ctatttggta     1380

ccaatggcta ccgaagaacc tagtgttatc gcagccttat ctaatggtgc taagatagca     1440

caaggtttta agactgttaa ccaacaaaga ttgatgagag gtcaaatcgt attctacgat     1500

gttgctgacc cagaatcatt aatcgataag ttgcaagtaa gagaagccga agtttttcaa     1560

caagctgaat tgtcttaccc ttcaatagtt aagagaggtg gtggtttgag agatttgcaa     1620

tacagaactt ttgacgaatc cttcgtcagt gtagatttct tagttgatgt caaggacgcc     1680

atgggtgcta atattgttaa cgcaatgttg gaaggtgtcg ccgaattgtt tagagaatgg     1740

ttcgctgaac aaaagatttt gttttctatc ttgtcaaact acgctacaga atctgtagtt     1800

accatgaaaa ctgcaattcc agtttccaga ttgagtaagg gttctaacgg tagagaaatc     1860

gctgaaaaga ttgttttggc atcaagatat gcctccttag acccttacag agctgttact     1920

cataataagg gtataatgaa cggtatcgaa gctgtcgtat tagcaaccgg taatgatact     1980

agagcagtat ctgcctcatg tcacgcattc gccgttaagg aaggtagata ccaaggtttg     2040

acatcatgga ccttggatgg tgaacaatta attggtgaaa tatccgttcc attggcttta     2100

gcaactgttg gtggtgctac aaaagtcttg cctaagagtc aagctgcagc cgatttgtta     2160

gccgtcactg acgctaagga attgtctaga gttgtcgctg cagtaggttt agctcaaaat     2220

ttggccgctt taagagcatt ggtttcagaa ggtattcaaa aaggtcatat ggctttgcaa     2280

gcaagatcct tagccatgac agttggtgct accggtaaag aagtcgaagc cgtagctcaa     2340

caattaaaaa gacaaaagac aatgaaccaa gacagagcaa tggctatatt aaacgatttg     2400

agaaagcaat aa                                                         2412


<210>  54
<211>  803
<212>  PRT
<213>  Enterococcus sp.

<400>  54

Met Lys Thr Val Val Ile Ile Asp Ala Leu Arg Thr Pro Ile Gly Lys 
1               5                   10                  15      


Tyr Lys Gly Ser Leu Ser Gln Val Ser Ala Val Asp Leu Gly Thr His 
            20                  25                  30          


Val Thr Thr Gln Leu Leu Lys Arg His Ser Thr Ile Ser Glu Glu Ile 
        35                  40                  45              


Asp Gln Val Ile Phe Gly Asn Val Leu Gln Ala Gly Asn Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ile Ala Ile Asn Ser Gly Leu Ser His Glu Ile Pro 
65                  70                  75                  80  


Ala Met Thr Val Asn Glu Val Cys Gly Ser Gly Met Lys Ala Val Ile 
                85                  90                  95      


Leu Ala Lys Gln Leu Ile Gln Leu Gly Glu Ala Glu Val Leu Ile Ala 
            100                 105                 110         


Gly Gly Ile Glu Asn Met Ser Gln Ala Pro Lys Leu Gln Arg Phe Asn 
        115                 120                 125             


Tyr Glu Thr Glu Ser Tyr Asp Ala Pro Phe Ser Ser Met Met Tyr Asp 
    130                 135                 140                 


Gly Leu Thr Asp Ala Phe Ser Gly Gln Ala Met Gly Leu Thr Ala Glu 
145                 150                 155                 160 


Asn Val Ala Glu Lys Tyr His Val Thr Arg Glu Glu Gln Asp Gln Phe 
                165                 170                 175     


Ser Val His Ser Gln Leu Lys Ala Ala Gln Ala Gln Ala Glu Gly Ile 
            180                 185                 190         


Phe Ala Asp Glu Ile Ala Pro Leu Glu Val Ser Gly Thr Leu Val Glu 
        195                 200                 205             


Lys Asp Glu Gly Ile Arg Pro Asn Ser Ser Val Glu Lys Leu Gly Thr 
    210                 215                 220                 


Leu Lys Thr Val Phe Lys Glu Asp Gly Thr Val Thr Ala Gly Asn Ala 
225                 230                 235                 240 


Ser Thr Ile Asn Asp Gly Ala Ser Ala Leu Ile Ile Ala Ser Gln Glu 
                245                 250                 255     


Tyr Ala Glu Ala His Gly Leu Pro Tyr Leu Ala Ile Ile Arg Asp Ser 
            260                 265                 270         


Val Glu Val Gly Ile Asp Pro Ala Tyr Met Gly Ile Ser Pro Ile Lys 
        275                 280                 285             


Ala Ile Gln Lys Leu Leu Ala Arg Asn Gln Leu Thr Thr Glu Glu Ile 
    290                 295                 300                 


Asp Leu Tyr Glu Ile Asn Glu Ala Phe Ala Ala Thr Ser Ile Val Val 
305                 310                 315                 320 


Gln Arg Glu Leu Ala Leu Pro Glu Glu Lys Val Asn Ile Tyr Gly Gly 
                325                 330                 335     


Gly Ile Ser Leu Gly His Ala Ile Gly Ala Thr Gly Ala Arg Leu Leu 
            340                 345                 350         


Thr Ser Leu Ser Tyr Gln Leu Asn Gln Lys Glu Lys Lys Tyr Gly Val 
        355                 360                 365             


Ala Ser Leu Cys Ile Gly Gly Gly Leu Gly Leu Ala Met Leu Leu Glu 
    370                 375                 380                 


Arg Pro Gln Gln Lys Lys Asn Ser Arg Phe Tyr Gln Met Ser Pro Glu 
385                 390                 395                 400 


Glu Arg Leu Ala Ser Leu Leu Asn Glu Gly Gln Ile Ser Ala Asp Thr 
                405                 410                 415     


Lys Lys Glu Phe Glu Asn Thr Ala Leu Ser Ser Gln Ile Ala Asn His 
            420                 425                 430         


Met Ile Glu Asn Gln Ile Ser Glu Thr Glu Val Pro Met Gly Val Gly 
        435                 440                 445             


Leu His Leu Thr Val Asp Glu Thr Asp Tyr Leu Val Pro Met Ala Thr 
    450                 455                 460                 


Glu Glu Pro Ser Val Ile Ala Ala Leu Ser Asn Gly Ala Lys Ile Ala 
465                 470                 475                 480 


Gln Gly Phe Lys Thr Val Asn Gln Gln Arg Leu Met Arg Gly Gln Ile 
                485                 490                 495     


Val Phe Tyr Asp Val Ala Asp Pro Glu Ser Leu Ile Asp Lys Leu Gln 
            500                 505                 510         


Val Arg Glu Ala Glu Val Phe Gln Gln Ala Glu Leu Ser Tyr Pro Ser 
        515                 520                 525             


Ile Val Lys Arg Gly Gly Gly Leu Arg Asp Leu Gln Tyr Arg Thr Phe 
    530                 535                 540                 


Asp Glu Ser Phe Val Ser Val Asp Phe Leu Val Asp Val Lys Asp Ala 
545                 550                 555                 560 


Met Gly Ala Asn Ile Val Asn Ala Met Leu Glu Gly Val Ala Glu Leu 
                565                 570                 575     


Phe Arg Glu Trp Phe Ala Glu Gln Lys Ile Leu Phe Ser Ile Leu Ser 
            580                 585                 590         


Asn Tyr Ala Thr Glu Ser Val Val Thr Met Lys Thr Ala Ile Pro Val 
        595                 600                 605             


Ser Arg Leu Ser Lys Gly Ser Asn Gly Arg Glu Ile Ala Glu Lys Ile 
    610                 615                 620                 


Val Leu Ala Ser Arg Tyr Ala Ser Leu Asp Pro Tyr Arg Ala Val Thr 
625                 630                 635                 640 


His Asn Lys Gly Ile Met Asn Gly Ile Glu Ala Val Val Leu Ala Thr 
                645                 650                 655     


Gly Asn Asp Thr Arg Ala Val Ser Ala Ser Cys His Ala Phe Ala Val 
            660                 665                 670         


Lys Glu Gly Arg Tyr Gln Gly Leu Thr Ser Trp Thr Leu Asp Gly Glu 
        675                 680                 685             


Gln Leu Ile Gly Glu Ile Ser Val Pro Leu Ala Leu Ala Thr Val Gly 
    690                 695                 700                 


Gly Ala Thr Lys Val Leu Pro Lys Ser Gln Ala Ala Ala Asp Leu Leu 
705                 710                 715                 720 


Ala Val Thr Asp Ala Lys Glu Leu Ser Arg Val Val Ala Ala Val Gly 
                725                 730                 735     


Leu Ala Gln Asn Leu Ala Ala Leu Arg Ala Leu Val Ser Glu Gly Ile 
            740                 745                 750         


Gln Lys Gly His Met Ala Leu Gln Ala Arg Ser Leu Ala Met Thr Val 
        755                 760                 765             


Gly Ala Thr Gly Lys Glu Val Glu Ala Val Ala Gln Gln Leu Lys Arg 
    770                 775                 780                 


Gln Lys Thr Met Asn Gln Asp Arg Ala Met Ala Ile Leu Asn Asp Leu 
785                 790                 795                 800 


Arg Lys Gln 
            


<210>  55
<211>  1152
<212>  DNA
<213>  Enterococcus sp.

<400>  55
atgacaattg ggattgataa aattagtttt tttgtgcccc cttattatat tgatatgacg       60

gcactggctg aagccagaaa tgtagaccct ggaaaatttc atattggtat tgggcaagac      120

caaatggcgg tgaacccaat cagccaagat attgtgacat ttgcagccaa tgccgcagaa      180

gcgatcttga ccaaagaaga taaagaggcc attgatatgg tgattgtcgg gactgagtcc      240

agtatcgatg agtcaaaagc ggccgcagtt gtcttacatc gtttaatggg gattcaacct      300

ttcgctcgct ctttcgaaat caaggaagct tgttacggag caacagcagg cttacagtta      360

gctaagaatc acgtagcctt acatccagat aaaaaagtct tggtcgtagc ggcagatatt      420

gcaaaatatg gcttaaattc tggcggtgag cctacacaag gagctggggc ggttgcaatg      480

ttagttgcta gtgaaccgcg cattttggct ttaaaagagg ataatgtgat gctgacgcaa      540

gatatctatg acttttggcg tccaacaggc cacccgtatc ctatggtcga tggtcctttg      600

tcaaacgaaa cctacatcca atcttttgcc caagtctggg atgaacataa aaaacgaacc      660

ggtcttgatt ttgcagatta tgatgcttta gcgttccata ttccttacac aaaaatgggc      720

aaaaaagcct tattagcaaa aatctccgac caaactgaag cagaacagga acgaatttta      780

gcccgttatg aagaaagtat cgtctatagt cgtcgcgtag gaaacttgta tacgggttca      840

ctttatctgg gactcatttc ccttttagaa aatgcaacga ctttaaccgc aggcaatcaa      900

attggtttat tcagttatgg ttctggtgct gtcgctgaat ttttcactgg tgaattagta      960

gctggttatc aaaatcattt acaaaaagaa actcatttag cactgctgga taatcggaca     1020

gaactttcta tcgctgaata tgaagccatg tttgcagaaa ctttagacac agacattgat     1080

caaacgttag aagatgaatt aaaatatagt atttctgcta ttaataatac cgttcgttct     1140

tatcgaaact aa                                                         1152


<210>  56
<211>  383
<212>  PRT
<213>  Enterococcus sp.

<400>  56

Met Thr Ile Gly Ile Asp Lys Ile Ser Phe Phe Val Pro Pro Tyr Tyr 
1               5                   10                  15      


Ile Asp Met Thr Ala Leu Ala Glu Ala Arg Asn Val Asp Pro Gly Lys 
            20                  25                  30          


Phe His Ile Gly Ile Gly Gln Asp Gln Met Ala Val Asn Pro Ile Ser 
        35                  40                  45              


Gln Asp Ile Val Thr Phe Ala Ala Asn Ala Ala Glu Ala Ile Leu Thr 
    50                  55                  60                  


Lys Glu Asp Lys Glu Ala Ile Asp Met Val Ile Val Gly Thr Glu Ser 
65                  70                  75                  80  


Ser Ile Asp Glu Ser Lys Ala Ala Ala Val Val Leu His Arg Leu Met 
                85                  90                  95      


Gly Ile Gln Pro Phe Ala Arg Ser Phe Glu Ile Lys Glu Ala Cys Tyr 
            100                 105                 110         


Gly Ala Thr Ala Gly Leu Gln Leu Ala Lys Asn His Val Ala Leu His 
        115                 120                 125             


Pro Asp Lys Lys Val Leu Val Val Ala Ala Asp Ile Ala Lys Tyr Gly 
    130                 135                 140                 


Leu Asn Ser Gly Gly Glu Pro Thr Gln Gly Ala Gly Ala Val Ala Met 
145                 150                 155                 160 


Leu Val Ala Ser Glu Pro Arg Ile Leu Ala Leu Lys Glu Asp Asn Val 
                165                 170                 175     


Met Leu Thr Gln Asp Ile Tyr Asp Phe Trp Arg Pro Thr Gly His Pro 
            180                 185                 190         


Tyr Pro Met Val Asp Gly Pro Leu Ser Asn Glu Thr Tyr Ile Gln Ser 
        195                 200                 205             


Phe Ala Gln Val Trp Asp Glu His Lys Lys Arg Thr Gly Leu Asp Phe 
    210                 215                 220                 


Ala Asp Tyr Asp Ala Leu Ala Phe His Ile Pro Tyr Thr Lys Met Gly 
225                 230                 235                 240 


Lys Lys Ala Leu Leu Ala Lys Ile Ser Asp Gln Thr Glu Ala Glu Gln 
                245                 250                 255     


Glu Arg Ile Leu Ala Arg Tyr Glu Glu Ser Ile Val Tyr Ser Arg Arg 
            260                 265                 270         


Val Gly Asn Leu Tyr Thr Gly Ser Leu Tyr Leu Gly Leu Ile Ser Leu 
        275                 280                 285             


Leu Glu Asn Ala Thr Thr Leu Thr Ala Gly Asn Gln Ile Gly Leu Phe 
    290                 295                 300                 


Ser Tyr Gly Ser Gly Ala Val Ala Glu Phe Phe Thr Gly Glu Leu Val 
305                 310                 315                 320 


Ala Gly Tyr Gln Asn His Leu Gln Lys Glu Thr His Leu Ala Leu Leu 
                325                 330                 335     


Asp Asn Arg Thr Glu Leu Ser Ile Ala Glu Tyr Glu Ala Met Phe Ala 
            340                 345                 350         


Glu Thr Leu Asp Thr Asp Ile Asp Gln Thr Leu Glu Asp Glu Leu Lys 
        355                 360                 365             


Tyr Ser Ile Ser Ala Ile Asn Asn Thr Val Arg Ser Tyr Arg Asn 
    370                 375                 380             


<210>  57
<211>  867
<212>  DNA
<213>  Saccharomyces sp.

<400>  57
atgactgccg acaacaatag tatgccccat ggtgcagtat ctagttacgc caaattagtg       60

caaaaccaaa cacctgaaga cattttggaa gagtttcctg aaattattcc attacaacaa      120

agacctaata cccgatctag tgagacgtca aatgacgaaa gcggagaaac atgtttttct      180

ggtcatgatg aggagcaaat taagttaatg aatgaaaatt gtattgtttt ggattgggac      240

gataatgcta ttggtgccgg taccaagaaa gtttgtcatt taatggaaaa tattgaaaag      300

ggtttactac atcgtgcatt ctccgtcttt attttcaatg aacaaggtga attactttta      360

caacaaagag ccactgaaaa aataactttc cctgatcttt ggactaacac atgctgctct      420

catccactat gtattgatga cgaattaggt ttgaagggta agctagacga taagattaag      480

ggcgctatta ctgcggcggt gagaaaacta gatcatgaat taggtattcc agaagatgaa      540

actaagacaa ggggtaagtt tcacttttta aacagaatcc attacatggc accaagcaat      600

gaaccatggg gtgaacatga aattgattac atcctatttt ataagatcaa cgctaaagaa      660

aacttgactg tcaacccaaa cgtcaatgaa gttagagact tcaaatgggt ttcaccaaat      720

gatttgaaaa ctatgtttgc tgacccaagt tacaagttta cgccttggtt taagattatt      780

tgcgagaatt acttattcaa ctggtgggag caattagatg acctttctga agtggaaaat      840

gacaggcaaa ttcatagaat gctataa                                          867


<210>  58
<211>  288
<212>  PRT
<213>  Saccharomyces sp.

<400>  58

Met Thr Ala Asp Asn Asn Ser Met Pro His Gly Ala Val Ser Ser Tyr 
1               5                   10                  15      


Ala Lys Leu Val Gln Asn Gln Thr Pro Glu Asp Ile Leu Glu Glu Phe 
            20                  25                  30          


Pro Glu Ile Ile Pro Leu Gln Gln Arg Pro Asn Thr Arg Ser Ser Glu 
        35                  40                  45              


Thr Ser Asn Asp Glu Ser Gly Glu Thr Cys Phe Ser Gly His Asp Glu 
    50                  55                  60                  


Glu Gln Ile Lys Leu Met Asn Glu Asn Cys Ile Val Leu Asp Trp Asp 
65                  70                  75                  80  


Asp Asn Ala Ile Gly Ala Gly Thr Lys Lys Val Cys His Leu Met Glu 
                85                  90                  95      


Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser Val Phe Ile Phe 
            100                 105                 110         


Asn Glu Gln Gly Glu Leu Leu Leu Gln Gln Arg Ala Thr Glu Lys Ile 
        115                 120                 125             


Thr Phe Pro Asp Leu Trp Thr Asn Thr Cys Cys Ser His Pro Leu Cys 
    130                 135                 140                 


Ile Asp Asp Glu Leu Gly Leu Lys Gly Lys Leu Asp Asp Lys Ile Lys 
145                 150                 155                 160 


Gly Ala Ile Thr Ala Ala Val Arg Lys Leu Asp His Glu Leu Gly Ile 
                165                 170                 175     


Pro Glu Asp Glu Thr Lys Thr Arg Gly Lys Phe His Phe Leu Asn Arg 
            180                 185                 190         


Ile His Tyr Met Ala Pro Ser Asn Glu Pro Trp Gly Glu His Glu Ile 
        195                 200                 205             


Asp Tyr Ile Leu Phe Tyr Lys Ile Asn Ala Lys Glu Asn Leu Thr Val 
    210                 215                 220                 


Asn Pro Asn Val Asn Glu Val Arg Asp Phe Lys Trp Val Ser Pro Asn 
225                 230                 235                 240 


Asp Leu Lys Thr Met Phe Ala Asp Pro Ser Tyr Lys Phe Thr Pro Trp 
                245                 250                 255     


Phe Lys Ile Ile Cys Glu Asn Tyr Leu Phe Asn Trp Trp Glu Gln Leu 
            260                 265                 270         


Asp Asp Leu Ser Glu Val Glu Asn Asp Arg Gln Ile His Arg Met Leu 
        275                 280                 285             


<210>  59
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant farnesyl pyrophosphate synthase (Erg20mut, F96W, N127W)

<400>  59
atggcttcag aaaaagaaat taggagagag agattcttga acgttttccc taaattagta       60

gaggaattga acgcatcgct tttggcttac ggtatgccta aggaagcatg tgactggtat      120

gcccactcat tgaactacaa cactccaggc ggtaagctaa atagaggttt gtccgttgtg      180

gacacgtatg ctattctctc caacaagacc gttgaacaat tggggcaaga agaatacgaa      240

aaggttgcca ttctaggttg gtgcattgag ttgttgcagg cttactggtt ggtcgccgat      300

gatatgatgg acaagtccat taccagaaga ggccaaccat gttggtacaa ggttcctgaa      360

gttggggaaa ttgccatctg ggacgcattc atgttagagg ctgctatcta caagcttttg      420

aaatctcact tcagaaacga aaaatactac atagatatca ccgaattgtt ccatgaggtc      480

accttccaaa ccgaattggg ccaattgatg gacttaatca ctgcacctga agacaaagtc      540

gacttgagta agttctccct aaagaagcac tccttcatag ttactttcaa gactgcttac      600

tattctttct acttgcctgt cgcattggcc atgtacgttg ccggtatcac ggatgaaaag      660

gatttgaaac aagccagaga tgtcttgatt ccattgggtg aatacttcca aattcaagat      720

gactacttag actgcttcgg taccccagaa cagatcggta agatcggtac agatatccaa      780

gataacaaat gttcttgggt aatcaacaag gcattggaac ttgcttccgc agaacaaaga      840

aagactttag acgaaaatta cggtaagaag gactcagtcg cagaagccaa atgcaaaaag      900

attttcaatg acttgaaaat tgaacagcta taccacgaat atgaagagtc tattgccaag      960

gatttgaagg ccaaaatttc tcaggtcgat gagtctcgtg gcttcaaagc tgatgtctta     1020

actgcgttct tgaacaaagt ttacaagaga agcaaatag                            1059


<210>  60
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant farnesyl pyrophosphate synthase (Erg20mut, F96W, N127W)

<400>  60

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Trp 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Trp Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  61
<211>  1356
<212>  DNA
<213>  Saccharomyces sp.

<400>  61
atgtcagagt tgagagcctt cagtgcccca gggaaagcgt tactagctgg tggatattta       60

gttttagata caaaatatga agcatttgta gtcggattat cggcaagaat gcatgctgta      120

gcccatcctt acggttcatt gcaagggtct gataagtttg aagtgcgtgt gaaaagtaaa      180

caatttaaag atggggagtg gctgtaccat ataagtccta aaagtggctt cattcctgtt      240

tcgataggcg gatctaagaa ccctttcatt gaaaaagtta tcgctaacgt atttagctac      300

tttaaaccta acatggacga ctactgcaat agaaacttgt tcgttattga tattttctct      360

gatgatgcct accattctca ggaggatagc gttaccgaac atcgtggcaa cagaagattg      420

agttttcatt cgcacagaat tgaagaagtt cccaaaacag ggctgggctc ctcggcaggt      480

ttagtcacag ttttaactac agctttggcc tccttttttg tatcggacct ggaaaataat      540

gtagacaaat atagagaagt tattcataat ttagcacaag ttgctcattg tcaagctcag      600

ggtaaaattg gaagcgggtt tgatgtagcg gcggcagcat atggatctat cagatataga      660

agattcccac ccgcattaat ctctaatttg ccagatattg gaagtgctac ttacggcagt      720

aaactggcgc atttggttga tgaagaagac tggaatatta cgattaaaag taaccattta      780

ccttcgggat taactttatg gatgggcgat attaagaatg gttcagaaac agtaaaactg      840

gtccagaagg taaaaaattg gtatgattcg catatgccag aaagcttgaa aatatataca      900

gaactcgatc atgcaaattc tagatttatg gatggactat ctaaactaga tcgcttacac      960

gagactcatg acgattacag cgatcagata tttgagtctc ttgagaggaa tgactgtacc     1020

tgtcaaaagt atcctgaaat cacagaagtt agagatgcag ttgccacaat tagacgttcc     1080

tttagaaaaa taactaaaga atctggtgcc gatatcgaac ctcccgtaca aactagctta     1140

ttggatgatt gccagacctt aaaaggagtt cttacttgct taatacctgg tgctggtggt     1200

tatgacgcca ttgcagtgat tactaagcaa gatgttgatc ttagggctca aaccgctaat     1260

gacaaaagat tttctaaggt tcaatggctg gatgtaactc aggctgactg gggtgttagg     1320

aaagaaaaag atccggaaac ttatcttgat aaataa                               1356


<210>  62
<211>  451
<212>  PRT
<213>  Saccharomyces sp.

<400>  62

Met Ser Glu Leu Arg Ala Phe Ser Ala Pro Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


Gly Gly Tyr Leu Val Leu Asp Thr Lys Tyr Glu Ala Phe Val Val Gly 
            20                  25                  30          


Leu Ser Ala Arg Met His Ala Val Ala His Pro Tyr Gly Ser Leu Gln 
        35                  40                  45              


Gly Ser Asp Lys Phe Glu Val Arg Val Lys Ser Lys Gln Phe Lys Asp 
    50                  55                  60                  


Gly Glu Trp Leu Tyr His Ile Ser Pro Lys Ser Gly Phe Ile Pro Val 
65                  70                  75                  80  


Ser Ile Gly Gly Ser Lys Asn Pro Phe Ile Glu Lys Val Ile Ala Asn 
                85                  90                  95      


Val Phe Ser Tyr Phe Lys Pro Asn Met Asp Asp Tyr Cys Asn Arg Asn 
            100                 105                 110         


Leu Phe Val Ile Asp Ile Phe Ser Asp Asp Ala Tyr His Ser Gln Glu 
        115                 120                 125             


Asp Ser Val Thr Glu His Arg Gly Asn Arg Arg Leu Ser Phe His Ser 
    130                 135                 140                 


His Arg Ile Glu Glu Val Pro Lys Thr Gly Leu Gly Ser Ser Ala Gly 
145                 150                 155                 160 


Leu Val Thr Val Leu Thr Thr Ala Leu Ala Ser Phe Phe Val Ser Asp 
                165                 170                 175     


Leu Glu Asn Asn Val Asp Lys Tyr Arg Glu Val Ile His Asn Leu Ala 
            180                 185                 190         


Gln Val Ala His Cys Gln Ala Gln Gly Lys Ile Gly Ser Gly Phe Asp 
        195                 200                 205             


Val Ala Ala Ala Ala Tyr Gly Ser Ile Arg Tyr Arg Arg Phe Pro Pro 
    210                 215                 220                 


Ala Leu Ile Ser Asn Leu Pro Asp Ile Gly Ser Ala Thr Tyr Gly Ser 
225                 230                 235                 240 


Lys Leu Ala His Leu Val Asp Glu Glu Asp Trp Asn Ile Thr Ile Lys 
                245                 250                 255     


Ser Asn His Leu Pro Ser Gly Leu Thr Leu Trp Met Gly Asp Ile Lys 
            260                 265                 270         


Asn Gly Ser Glu Thr Val Lys Leu Val Gln Lys Val Lys Asn Trp Tyr 
        275                 280                 285             


Asp Ser His Met Pro Glu Ser Leu Lys Ile Tyr Thr Glu Leu Asp His 
    290                 295                 300                 


Ala Asn Ser Arg Phe Met Asp Gly Leu Ser Lys Leu Asp Arg Leu His 
305                 310                 315                 320 


Glu Thr His Asp Asp Tyr Ser Asp Gln Ile Phe Glu Ser Leu Glu Arg 
                325                 330                 335     


Asn Asp Cys Thr Cys Gln Lys Tyr Pro Glu Ile Thr Glu Val Arg Asp 
            340                 345                 350         


Ala Val Ala Thr Ile Arg Arg Ser Phe Arg Lys Ile Thr Lys Glu Ser 
        355                 360                 365             


Gly Ala Asp Ile Glu Pro Pro Val Gln Thr Ser Leu Leu Asp Asp Cys 
    370                 375                 380                 


Gln Thr Leu Lys Gly Val Leu Thr Cys Leu Ile Pro Gly Ala Gly Gly 
385                 390                 395                 400 


Tyr Asp Ala Ile Ala Val Ile Thr Lys Gln Asp Val Asp Leu Arg Ala 
                405                 410                 415     


Gln Thr Ala Asn Asp Lys Arg Phe Ser Lys Val Gln Trp Leu Asp Val 
            420                 425                 430         


Thr Gln Ala Asp Trp Gly Val Arg Lys Glu Lys Asp Pro Glu Thr Tyr 
        435                 440                 445             


Leu Asp Lys 
    450     


<210>  63
<211>  1332
<212>  DNA
<213>  Saccharomyces sp.

<400>  63
atgtcattac cgttcttaac ttctgcaccg ggaaaggtta ttatttttgg tgaacactct       60

gctgtgtaca acaagcctgc cgtcgctgct agtgtgtctg cgttgagaac ctacctgcta      120

ataagcgagt catctgcacc agatactatt gaattggact tcccggacat tagctttaat      180

cataagtggt ccatcaatga tttcaatgcc atcaccgagg atcaagtaaa ctcccaaaaa      240

ttggccaagg ctcaacaagc caccgatggc ttgtctcagg aactcgttag tcttttggat      300

ccgttgttag ctcaactatc cgaatccttc cactaccatg cagcgttttg tttcctgtat      360

atgtttgttt gcctatgccc ccatgccaag aatattaagt tttctttaaa gtctacttta      420

cccatcggtg ctgggttggg ctcaagcgcc tctatttctg tatcactggc cttagctatg      480

gcctacttgg gggggttaat aggatctaat gacttggaaa agctgtcaga aaacgataag      540

catatagtga atcaatgggc cttcataggt gaaaagtgta ttcacggtac cccttcagga      600

atagataacg ctgtggccac ttatggtaat gccctgctat ttgaaaaaga ctcacataat      660

ggaacaataa acacaaacaa ttttaagttc ttagatgatt tcccagccat tccaatgatc      720

ctaacctata ctagaattcc aaggtctaca aaagatcttg ttgctcgcgt tcgtgtgttg      780

gtcaccgaga aatttcctga agttatgaag ccaattctag atgccatggg tgaatgtgcc      840

ctacaaggct tagagatcat gactaagtta agtaaatgta aaggcaccga tgacgaggct      900

gtagaaacta ataatgaact gtatgaacaa ctattggaat tgataagaat aaatcatgga      960

ctgcttgtct caatcggtgt ttctcatcct ggattagaac ttattaaaaa tctgagcgat     1020

gatttgagaa ttggctccac aaaacttacc ggtgctggtg gcggcggttg ctctttgact     1080

ttgttacgaa gagacattac tcaagagcaa attgacagct tcaaaaagaa attgcaagat     1140

gattttagtt acgagacatt tgaaacagac ttgggtggga ctggctgctg tttgttaagc     1200

gcaaaaaatt tgaataaaga tcttaaaatc aaatccctag tattccaatt atttgaaaat     1260

aaaactacca caaagcaaca aattgacgat ctattattgc caggaaacac gaatttacca     1320

tggacttcat aa                                                         1332


<210>  64
<211>  443
<212>  PRT
<213>  Saccharomyces sp.

<400>  64

Met Ser Leu Pro Phe Leu Thr Ser Ala Pro Gly Lys Val Ile Ile Phe 
1               5                   10                  15      


Gly Glu His Ser Ala Val Tyr Asn Lys Pro Ala Val Ala Ala Ser Val 
            20                  25                  30          


Ser Ala Leu Arg Thr Tyr Leu Leu Ile Ser Glu Ser Ser Ala Pro Asp 
        35                  40                  45              


Thr Ile Glu Leu Asp Phe Pro Asp Ile Ser Phe Asn His Lys Trp Ser 
    50                  55                  60                  


Ile Asn Asp Phe Asn Ala Ile Thr Glu Asp Gln Val Asn Ser Gln Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Gln Gln Ala Thr Asp Gly Leu Ser Gln Glu Leu Val 
                85                  90                  95      


Ser Leu Leu Asp Pro Leu Leu Ala Gln Leu Ser Glu Ser Phe His Tyr 
            100                 105                 110         


His Ala Ala Phe Cys Phe Leu Tyr Met Phe Val Cys Leu Cys Pro His 
        115                 120                 125             


Ala Lys Asn Ile Lys Phe Ser Leu Lys Ser Thr Leu Pro Ile Gly Ala 
    130                 135                 140                 


Gly Leu Gly Ser Ser Ala Ser Ile Ser Val Ser Leu Ala Leu Ala Met 
145                 150                 155                 160 


Ala Tyr Leu Gly Gly Leu Ile Gly Ser Asn Asp Leu Glu Lys Leu Ser 
                165                 170                 175     


Glu Asn Asp Lys His Ile Val Asn Gln Trp Ala Phe Ile Gly Glu Lys 
            180                 185                 190         


Cys Ile His Gly Thr Pro Ser Gly Ile Asp Asn Ala Val Ala Thr Tyr 
        195                 200                 205             


Gly Asn Ala Leu Leu Phe Glu Lys Asp Ser His Asn Gly Thr Ile Asn 
    210                 215                 220                 


Thr Asn Asn Phe Lys Phe Leu Asp Asp Phe Pro Ala Ile Pro Met Ile 
225                 230                 235                 240 


Leu Thr Tyr Thr Arg Ile Pro Arg Ser Thr Lys Asp Leu Val Ala Arg 
                245                 250                 255     


Val Arg Val Leu Val Thr Glu Lys Phe Pro Glu Val Met Lys Pro Ile 
            260                 265                 270         


Leu Asp Ala Met Gly Glu Cys Ala Leu Gln Gly Leu Glu Ile Met Thr 
        275                 280                 285             


Lys Leu Ser Lys Cys Lys Gly Thr Asp Asp Glu Ala Val Glu Thr Asn 
    290                 295                 300                 


Asn Glu Leu Tyr Glu Gln Leu Leu Glu Leu Ile Arg Ile Asn His Gly 
305                 310                 315                 320 


Leu Leu Val Ser Ile Gly Val Ser His Pro Gly Leu Glu Leu Ile Lys 
                325                 330                 335     


Asn Leu Ser Asp Asp Leu Arg Ile Gly Ser Thr Lys Leu Thr Gly Ala 
            340                 345                 350         


Gly Gly Gly Gly Cys Ser Leu Thr Leu Leu Arg Arg Asp Ile Thr Gln 
        355                 360                 365             


Glu Gln Ile Asp Ser Phe Lys Lys Lys Leu Gln Asp Asp Phe Ser Tyr 
    370                 375                 380                 


Glu Thr Phe Glu Thr Asp Leu Gly Gly Thr Gly Cys Cys Leu Leu Ser 
385                 390                 395                 400 


Ala Lys Asn Leu Asn Lys Asp Leu Lys Ile Lys Ser Leu Val Phe Gln 
                405                 410                 415     


Leu Phe Glu Asn Lys Thr Thr Thr Lys Gln Gln Ile Asp Asp Leu Leu 
            420                 425                 430         


Leu Pro Gly Asn Thr Asn Leu Pro Trp Thr Ser 
        435                 440             


<210>  65
<211>  1191
<212>  DNA
<213>  Saccharomyces sp.

<400>  65
atgaccgttt acacagcatc cgttaccgca cccgtcaaca tcgcaaccct taagtattgg       60

gggaaaaggg acacgaagtt gaatctgccc accaattcgt ccatatcagt gactttatcg      120

caagatgacc tcagaacgtt gacctctgcg gctactgcac ctgagtttga acgcgacact      180

ttgtggttaa atggagaacc acacagcatc gacaatgaaa gaactcaaaa ttgtctgcgc      240

gacctacgcc aattaagaaa ggaaatggaa tcgaaggacg cctcattgcc cacattatct      300

caatggaaac tccacattgt ctccgaaaat aactttccta cagcagctgg tttagcttcc      360

tccgctgctg gctttgctgc attggtctct gcaattgcta agttatacca attaccacag      420

tcaacttcag aaatatctag aatagcaaga aaggggtctg gttcagcttg tagatcgttg      480

tttggcggat acgtggcctg ggaaatggga aaagctgaag atggtcatga ttccatggca      540

gtacaaatcg cagacagctc tgactggcct cagatgaaag cttgtgtcct agttgtcagc      600

gatattaaaa aggatgtgag ttccactcag ggtatgcaat tgaccgtggc aacctccgaa      660

ctatttaaag aaagaattga acatgtcgta ccaaagagat ttgaagtcat gcgtaaagcc      720

attgttgaaa aagatttcgc cacctttgca aaggaaacaa tgatggattc caactctttc      780

catgccacat gtttggactc tttccctcca atattctaca tgaatgacac ttccaagcgt      840

atcatcagtt ggtgccacac cattaatcag ttttacggag aaacaatcgt tgcatacacg      900

tttgatgcag gtccaaatgc tgtgttgtac tacttagctg aaaatgagtc gaaactcttt      960

gcatttatct ataaattgtt tggctctgtt cctggatggg acaagaaatt tactactgag     1020

cagcttgagg ctttcaacca tcaatttgaa tcatctaact ttactgcacg tgaattggat     1080

cttgagttgc aaaaggatgt tgccagagtg attttaactc aagtcggttc aggcccacaa     1140

gaaacaaacg aatctttgat tgacgcaaag actggtctac caaaggaata a              1191


<210>  66
<211>  396
<212>  PRT
<213>  Saccharomyces sp.

<400>  66

Met Thr Val Tyr Thr Ala Ser Val Thr Ala Pro Val Asn Ile Ala Thr 
1               5                   10                  15      


Leu Lys Tyr Trp Gly Lys Arg Asp Thr Lys Leu Asn Leu Pro Thr Asn 
            20                  25                  30          


Ser Ser Ile Ser Val Thr Leu Ser Gln Asp Asp Leu Arg Thr Leu Thr 
        35                  40                  45              


Ser Ala Ala Thr Ala Pro Glu Phe Glu Arg Asp Thr Leu Trp Leu Asn 
    50                  55                  60                  


Gly Glu Pro His Ser Ile Asp Asn Glu Arg Thr Gln Asn Cys Leu Arg 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Arg Lys Glu Met Glu Ser Lys Asp Ala Ser Leu 
                85                  90                  95      


Pro Thr Leu Ser Gln Trp Lys Leu His Ile Val Ser Glu Asn Asn Phe 
            100                 105                 110         


Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala Ala Gly Phe Ala Ala Leu 
        115                 120                 125             


Val Ser Ala Ile Ala Lys Leu Tyr Gln Leu Pro Gln Ser Thr Ser Glu 
    130                 135                 140                 


Ile Ser Arg Ile Ala Arg Lys Gly Ser Gly Ser Ala Cys Arg Ser Leu 
145                 150                 155                 160 


Phe Gly Gly Tyr Val Ala Trp Glu Met Gly Lys Ala Glu Asp Gly His 
                165                 170                 175     


Asp Ser Met Ala Val Gln Ile Ala Asp Ser Ser Asp Trp Pro Gln Met 
            180                 185                 190         


Lys Ala Cys Val Leu Val Val Ser Asp Ile Lys Lys Asp Val Ser Ser 
        195                 200                 205             


Thr Gln Gly Met Gln Leu Thr Val Ala Thr Ser Glu Leu Phe Lys Glu 
    210                 215                 220                 


Arg Ile Glu His Val Val Pro Lys Arg Phe Glu Val Met Arg Lys Ala 
225                 230                 235                 240 


Ile Val Glu Lys Asp Phe Ala Thr Phe Ala Lys Glu Thr Met Met Asp 
                245                 250                 255     


Ser Asn Ser Phe His Ala Thr Cys Leu Asp Ser Phe Pro Pro Ile Phe 
            260                 265                 270         


Tyr Met Asn Asp Thr Ser Lys Arg Ile Ile Ser Trp Cys His Thr Ile 
        275                 280                 285             


Asn Gln Phe Tyr Gly Glu Thr Ile Val Ala Tyr Thr Phe Asp Ala Gly 
    290                 295                 300                 


Pro Asn Ala Val Leu Tyr Tyr Leu Ala Glu Asn Glu Ser Lys Leu Phe 
305                 310                 315                 320 


Ala Phe Ile Tyr Lys Leu Phe Gly Ser Val Pro Gly Trp Asp Lys Lys 
                325                 330                 335     


Phe Thr Thr Glu Gln Leu Glu Ala Phe Asn His Gln Phe Glu Ser Ser 
            340                 345                 350         


Asn Phe Thr Ala Arg Glu Leu Asp Leu Glu Leu Gln Lys Asp Val Ala 
        355                 360                 365             


Arg Val Ile Leu Thr Gln Val Gly Ser Gly Pro Gln Glu Thr Asn Glu 
    370                 375                 380                 


Ser Leu Ile Asp Ala Lys Thr Gly Leu Pro Lys Glu 
385                 390                 395     


<210>  67
<211>  2751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered phosphomevalonate kinase/mevalonate kinase 
       (Erg8-T2A-Erg12)

<400>  67
atgtcagagt tgagagcctt cagtgcccca gggaaagcgt tactagctgg tggatattta       60

gttttagata caaaatatga agcatttgta gtcggattat cggcaagaat gcatgctgta      120

gcccatcctt acggttcatt gcaagggtct gataagtttg aagtgcgtgt gaaaagtaaa      180

caatttaaag atggggagtg gctgtaccat ataagtccta aaagtggctt cattcctgtt      240

tcgataggcg gatctaagaa ccctttcatt gaaaaagtta tcgctaacgt atttagctac      300

tttaaaccta acatggacga ctactgcaat agaaacttgt tcgttattga tattttctct      360

gatgatgcct accattctca ggaggatagc gttaccgaac atcgtggcaa cagaagattg      420

agttttcatt cgcacagaat tgaagaagtt cccaaaacag ggctgggctc ctcggcaggt      480

ttagtcacag ttttaactac agctttggcc tccttttttg tatcggacct ggaaaataat      540

gtagacaaat atagagaagt tattcataat ttagcacaag ttgctcattg tcaagctcag      600

ggtaaaattg gaagcgggtt tgatgtagcg gcggcagcat atggatctat cagatataga      660

agattcccac ccgcattaat ctctaatttg ccagatattg gaagtgctac ttacggcagt      720

aaactggcgc atttggttga tgaagaagac tggaatatta cgattaaaag taaccattta      780

ccttcgggat taactttatg gatgggcgat attaagaatg gttcagaaac agtaaaactg      840

gtccagaagg taaaaaattg gtatgattcg catatgccag aaagcttgaa aatatataca      900

gaactcgatc atgcaaattc tagatttatg gatggactat ctaaactaga tcgcttacac      960

gagactcatg acgattacag cgatcagata tttgagtctc ttgagaggaa tgactgtacc     1020

tgtcaaaagt atcctgaaat cacagaagtt agagatgcag ttgccacaat tagacgttcc     1080

tttagaaaaa taactaaaga atctggtgcc gatatcgaac ctcccgtaca aactagctta     1140

ttggatgatt gccagacctt aaaaggagtt cttacttgct taatacctgg tgctggtggt     1200

tatgacgcca ttgcagtgat tactaagcaa gatgttgatc ttagggctca aaccgctaat     1260

gacaaaagat tttctaaggt tcaatggctg gatgtaactc aggctgactg gggtgttagg     1320

aaagaaaaag atccggaaac ttatcttgat aaaaagcttg agggcagagg aagtcttcta     1380

acatgcggtg acgtggagga gaatcccggc cctgctagca tgtcattacc gttcttaact     1440

tctgcaccgg gaaaggttat tatttttggt gaacactctg ctgtgtacaa caagcctgcc     1500

gtcgctgcta gtgtgtctgc gttgagaacc tacctgctaa taagcgagtc atctgcacca     1560

gatactattg aattggactt cccggacatt agctttaatc ataagtggtc catcaatgat     1620

ttcaatgcca tcaccgagga tcaagtaaac tcccaaaaat tggccaaggc tcaacaagcc     1680

accgatggct tgtctcagga actcgttagt cttttggatc cgttgttagc tcaactatcc     1740

gaatccttcc actaccatgc agcgttttgt ttcctgtata tgtttgtttg cctatgcccc     1800

catgccaaga atattaagtt ttctttaaag tctactttac ccatcggtgc tgggttgggc     1860

tcaagcgcct ctatttctgt atcactggcc ttagctatgg cctacttggg ggggttaata     1920

ggatctaatg acttggaaaa gctgtcagaa aacgataagc atatagtgaa tcaatgggcc     1980

ttcataggtg aaaagtgtat tcacggtacc ccttcaggaa tagataacgc tgtggccact     2040

tatggtaatg ccctgctatt tgaaaaagac tcacataatg gaacaataaa cacaaacaat     2100

tttaagttct tagatgattt cccagccatt ccaatgatcc taacctatac tagaattcca     2160

aggtctacaa aagatcttgt tgctcgcgtt cgtgtgttgg tcaccgagaa atttcctgaa     2220

gttatgaagc caattctaga tgccatgggt gaatgtgccc tacaaggctt agagatcatg     2280

actaagttaa gtaaatgtaa aggcaccgat gacgaggctg tagaaactaa taatgaactg     2340

tatgaacaac tattggaatt gataagaata aatcatggac tgcttgtctc aatcggtgtt     2400

tctcatcctg gattagaact tattaaaaat ctgagcgatg atttgagaat tggctccaca     2460

aaacttaccg gtgctggtgg cggcggttgc tctttgactt tgttacgaag agacattact     2520

caagagcaaa ttgacagctt caaaaagaaa ttgcaagatg attttagtta cgagacattt     2580

gaaacagact tgggtgggac tggctgctgt ttgttaagcg caaaaaattt gaataaagat     2640

cttaaaatca aatccctagt attccaatta tttgaaaata aaactaccac aaagcaacaa     2700

attgacgatc tattattgcc aggaaacacg aatttaccat ggacttcata a              2751


<210>  68
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered phosphomevalonate kinase/mevalonate kinase 
       (Erg8-T2A-Erg12)

<400>  68

Met Ser Glu Leu Arg Ala Phe Ser Ala Pro Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


Gly Gly Tyr Leu Val Leu Asp Thr Lys Tyr Glu Ala Phe Val Val Gly 
            20                  25                  30          


Leu Ser Ala Arg Met His Ala Val Ala His Pro Tyr Gly Ser Leu Gln 
        35                  40                  45              


Gly Ser Asp Lys Phe Glu Val Arg Val Lys Ser Lys Gln Phe Lys Asp 
    50                  55                  60                  


Gly Glu Trp Leu Tyr His Ile Ser Pro Lys Ser Gly Phe Ile Pro Val 
65                  70                  75                  80  


Ser Ile Gly Gly Ser Lys Asn Pro Phe Ile Glu Lys Val Ile Ala Asn 
                85                  90                  95      


Val Phe Ser Tyr Phe Lys Pro Asn Met Asp Asp Tyr Cys Asn Arg Asn 
            100                 105                 110         


Leu Phe Val Ile Asp Ile Phe Ser Asp Asp Ala Tyr His Ser Gln Glu 
        115                 120                 125             


Asp Ser Val Thr Glu His Arg Gly Asn Arg Arg Leu Ser Phe His Ser 
    130                 135                 140                 


His Arg Ile Glu Glu Val Pro Lys Thr Gly Leu Gly Ser Ser Ala Gly 
145                 150                 155                 160 


Leu Val Thr Val Leu Thr Thr Ala Leu Ala Ser Phe Phe Val Ser Asp 
                165                 170                 175     


Leu Glu Asn Asn Val Asp Lys Tyr Arg Glu Val Ile His Asn Leu Ala 
            180                 185                 190         


Gln Val Ala His Cys Gln Ala Gln Gly Lys Ile Gly Ser Gly Phe Asp 
        195                 200                 205             


Val Ala Ala Ala Ala Tyr Gly Ser Ile Arg Tyr Arg Arg Phe Pro Pro 
    210                 215                 220                 


Ala Leu Ile Ser Asn Leu Pro Asp Ile Gly Ser Ala Thr Tyr Gly Ser 
225                 230                 235                 240 


Lys Leu Ala His Leu Val Asp Glu Glu Asp Trp Asn Ile Thr Ile Lys 
                245                 250                 255     


Ser Asn His Leu Pro Ser Gly Leu Thr Leu Trp Met Gly Asp Ile Lys 
            260                 265                 270         


Asn Gly Ser Glu Thr Val Lys Leu Val Gln Lys Val Lys Asn Trp Tyr 
        275                 280                 285             


Asp Ser His Met Pro Glu Ser Leu Lys Ile Tyr Thr Glu Leu Asp His 
    290                 295                 300                 


Ala Asn Ser Arg Phe Met Asp Gly Leu Ser Lys Leu Asp Arg Leu His 
305                 310                 315                 320 


Glu Thr His Asp Asp Tyr Ser Asp Gln Ile Phe Glu Ser Leu Glu Arg 
                325                 330                 335     


Asn Asp Cys Thr Cys Gln Lys Tyr Pro Glu Ile Thr Glu Val Arg Asp 
            340                 345                 350         


Ala Val Ala Thr Ile Arg Arg Ser Phe Arg Lys Ile Thr Lys Glu Ser 
        355                 360                 365             


Gly Ala Asp Ile Glu Pro Pro Val Gln Thr Ser Leu Leu Asp Asp Cys 
    370                 375                 380                 


Gln Thr Leu Lys Gly Val Leu Thr Cys Leu Ile Pro Gly Ala Gly Gly 
385                 390                 395                 400 


Tyr Asp Ala Ile Ala Val Ile Thr Lys Gln Asp Val Asp Leu Arg Ala 
                405                 410                 415     


Gln Thr Ala Asn Asp Lys Arg Phe Ser Lys Val Gln Trp Leu Asp Val 
            420                 425                 430         


Thr Gln Ala Asp Trp Gly Val Arg Lys Glu Lys Asp Pro Glu Thr Tyr 
        435                 440                 445             


Leu Asp Lys Lys Leu Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
    450                 455                 460                 


Val Glu Glu Asn Pro Gly Pro Ala Ser Met Ser Leu Pro Phe Leu Thr 
465                 470                 475                 480 


Ser Ala Pro Gly Lys Val Ile Ile Phe Gly Glu His Ser Ala Val Tyr 
                485                 490                 495     


Asn Lys Pro Ala Val Ala Ala Ser Val Ser Ala Leu Arg Thr Tyr Leu 
            500                 505                 510         


Leu Ile Ser Glu Ser Ser Ala Pro Asp Thr Ile Glu Leu Asp Phe Pro 
        515                 520                 525             


Asp Ile Ser Phe Asn His Lys Trp Ser Ile Asn Asp Phe Asn Ala Ile 
    530                 535                 540                 


Thr Glu Asp Gln Val Asn Ser Gln Lys Leu Ala Lys Ala Gln Gln Ala 
545                 550                 555                 560 


Thr Asp Gly Leu Ser Gln Glu Leu Val Ser Leu Leu Asp Pro Leu Leu 
                565                 570                 575     


Ala Gln Leu Ser Glu Ser Phe His Tyr His Ala Ala Phe Cys Phe Leu 
            580                 585                 590         


Tyr Met Phe Val Cys Leu Cys Pro His Ala Lys Asn Ile Lys Phe Ser 
        595                 600                 605             


Leu Lys Ser Thr Leu Pro Ile Gly Ala Gly Leu Gly Ser Ser Ala Ser 
    610                 615                 620                 


Ile Ser Val Ser Leu Ala Leu Ala Met Ala Tyr Leu Gly Gly Leu Ile 
625                 630                 635                 640 


Gly Ser Asn Asp Leu Glu Lys Leu Ser Glu Asn Asp Lys His Ile Val 
                645                 650                 655     


Asn Gln Trp Ala Phe Ile Gly Glu Lys Cys Ile His Gly Thr Pro Ser 
            660                 665                 670         


Gly Ile Asp Asn Ala Val Ala Thr Tyr Gly Asn Ala Leu Leu Phe Glu 
        675                 680                 685             


Lys Asp Ser His Asn Gly Thr Ile Asn Thr Asn Asn Phe Lys Phe Leu 
    690                 695                 700                 


Asp Asp Phe Pro Ala Ile Pro Met Ile Leu Thr Tyr Thr Arg Ile Pro 
705                 710                 715                 720 


Arg Ser Thr Lys Asp Leu Val Ala Arg Val Arg Val Leu Val Thr Glu 
                725                 730                 735     


Lys Phe Pro Glu Val Met Lys Pro Ile Leu Asp Ala Met Gly Glu Cys 
            740                 745                 750         


Ala Leu Gln Gly Leu Glu Ile Met Thr Lys Leu Ser Lys Cys Lys Gly 
        755                 760                 765             


Thr Asp Asp Glu Ala Val Glu Thr Asn Asn Glu Leu Tyr Glu Gln Leu 
    770                 775                 780                 


Leu Glu Leu Ile Arg Ile Asn His Gly Leu Leu Val Ser Ile Gly Val 
785                 790                 795                 800 


Ser His Pro Gly Leu Glu Leu Ile Lys Asn Leu Ser Asp Asp Leu Arg 
                805                 810                 815     


Ile Gly Ser Thr Lys Leu Thr Gly Ala Gly Gly Gly Gly Cys Ser Leu 
            820                 825                 830         


Thr Leu Leu Arg Arg Asp Ile Thr Gln Glu Gln Ile Asp Ser Phe Lys 
        835                 840                 845             


Lys Lys Leu Gln Asp Asp Phe Ser Tyr Glu Thr Phe Glu Thr Asp Leu 
    850                 855                 860                 


Gly Gly Thr Gly Cys Cys Leu Leu Ser Ala Lys Asn Leu Asn Lys Asp 
865                 870                 875                 880 


Leu Lys Ile Lys Ser Leu Val Phe Gln Leu Phe Glu Asn Lys Thr Thr 
                885                 890                 895     


Thr Lys Gln Gln Ile Asp Asp Leu Leu Leu Pro Gly Asn Thr Asn Leu 
            900                 905                 910         


Pro Trp Thr Ser 
        915     


<210>  69
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial neryl pyrophosphate (NPP) synthase (NPPS) nucleotide 
       sequence

<400>  69
atgtgctcac ttaatttgca aacggaaaag ctatgctatg aagacaatga caatgacttg       60

gacgaggaac tgatgccgaa gcacatagcg ctaatcatgg atggtaatag acgttgggca      120

aaagacaagg gcttagaagt gtacgaaggg cacaaacata taatcccgaa actaaaagaa      180

atatgtgaca tatcctccaa gttggggatt cagatcatca cagcgttcgc gttctccaca      240

gagaactgga agagatccaa ggaggaagtc gatttcctat tgcagatgtt tgaagaaatc      300

tatgacgaat ttagccgttc tggggtgaga gtgagtatca tcggatgcaa aagcgatttg      360

ccgatgaccc ttcaaaaatg tatcgcattg acagaggaaa cgacgaaagg caataaggga      420

ttacacctgg tcatagcact taactacggt gggtattacg atatcctaca agcaacgaag      480

tccattgtaa acaaggctat gaatggttta ttggacgttg aagacatcaa taaaaatctg      540

ttcgaccaag aattagaaag caaatgccct aaccctgact tgctgatcag aactggggga      600

gaacagaggg tctctaattt tcttctatgg caattggctt atactgagtt ctattttacc      660

aatactttat tccctgactt tggtgaagag gacctgaaag aagccatcat gaattttcaa      720

cagagacacc gtagattcgg aggacatact tattga                                756


<210>  70
<211>  251
<212>  PRT
<213>  Solanum sp.

<400>  70

Met Cys Ser Leu Asn Leu Gln Thr Glu Lys Leu Cys Tyr Glu Asp Asn 
1               5                   10                  15      


Asp Asn Asp Leu Asp Glu Glu Leu Met Pro Lys His Ile Ala Leu Ile 
            20                  25                  30          


Met Asp Gly Asn Arg Arg Trp Ala Lys Asp Lys Gly Leu Glu Val Tyr 
        35                  40                  45              


Glu Gly His Lys His Ile Ile Pro Lys Leu Lys Glu Ile Cys Asp Ile 
    50                  55                  60                  


Ser Ser Lys Leu Gly Ile Gln Ile Ile Thr Ala Phe Ala Phe Ser Thr 
65                  70                  75                  80  


Glu Asn Trp Lys Arg Ser Lys Glu Glu Val Asp Phe Leu Leu Gln Met 
                85                  90                  95      


Phe Glu Glu Ile Tyr Asp Glu Phe Ser Arg Ser Gly Val Arg Val Ser 
            100                 105                 110         


Ile Ile Gly Cys Lys Ser Asp Leu Pro Met Thr Leu Gln Lys Cys Ile 
        115                 120                 125             


Ala Leu Thr Glu Glu Thr Thr Lys Gly Asn Lys Gly Leu His Leu Val 
    130                 135                 140                 


Ile Ala Leu Asn Tyr Gly Gly Tyr Tyr Asp Ile Leu Gln Ala Thr Lys 
145                 150                 155                 160 


Ser Ile Val Asn Lys Ala Met Asn Gly Leu Leu Asp Val Glu Asp Ile 
                165                 170                 175     


Asn Lys Asn Leu Phe Asp Gln Glu Leu Glu Ser Lys Cys Pro Asn Pro 
            180                 185                 190         


Asp Leu Leu Ile Arg Thr Gly Gly Glu Gln Arg Val Ser Asn Phe Leu 
        195                 200                 205             


Leu Trp Gln Leu Ala Tyr Thr Glu Phe Tyr Phe Thr Asn Thr Leu Phe 
    210                 215                 220                 


Pro Asp Phe Gly Glu Glu Asp Leu Lys Glu Ala Ile Met Asn Phe Gln 
225                 230                 235                 240 


Gln Arg His Arg Arg Phe Gly Gly His Thr Tyr 
                245                 250     


<210>  71
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial geranylgeranyl pyrophosphate synthase large subunit 
       (GPPSlsu) nucleotide sequence

<400>  71
atgagcaccg tgaatctgac ctgggtgcag acgtgctcta tgttcaacca gggcgggcgt       60

tcccgttcat tgtcaacctt caacttaaat ctgtaccatc cattgaagaa aacgcctttc      120

tctatccaga cacctaagca gaaaaggcca acttccccct tctcatctat cagtgccgta      180

ttaacggagc aggaagcagt aaaggagggt gacgaggaaa aaagcatatt taacttcaaa      240

tcttatatgg ttcagaaagc taatagcgtg aatcaggcac tagattctgc ggtgttattg      300

agagacccca ttatgataca tgaatctatg cgttactctt tgcttgcggg cggcaagcgt      360

gtcagaccga tgttatgctt aagtgcgtgc gagttagtag gaggtaaaga gtctgtagca      420

atgcccgcag catgtgctgt agaaatgata cacacaatgt cactgattca cgatgatctt      480

ccttgcatgg ataacgacga tcttcgtaga ggtaagccaa ccaaccacaa ggtattcggg      540

gaagacgtgg cagttttagc aggagacgcg ctactagcgt tcgcgtttga acacatggca      600

gttagcacag taggagttcc agcagcaaaa atagttaggg ctataggaga gttagcaaag      660

tccatcggta gcgagggcct tgttgccgga caggtagttg atatcgatag tgaagggttg      720

gctaacgtgg gactagaaca actggagttc atccacctac acaagacagg ggcactgctt      780

gaagcgagtg ttgtacttgg ggctattctg gggggaggaa cagatgagga ggtagaaaaa      840

ctacgtagtt ttgccaggtg tataggacta ctatttcaag ttgtagatga tatccttgac      900

gtcacgaaga gtagtcaaga gttaggaaaa acagcaggga aagatctagt tgccgataaa      960

gtaacctacc ccaggctaat gggtatcgat aaatctcgtg agttcgccga acaattaaat     1020

actgaggcta agcaacattt aagcgggttt gatcctatta aggctgcgcc gctgattgct     1080

ctagcaaact atattgcata tagacagaac tga                                  1113


<210>  72
<211>  370
<212>  PRT
<213>  Cannabis sativa

<400>  72

Met Ser Thr Val Asn Leu Thr Trp Val Gln Thr Cys Ser Met Phe Asn 
1               5                   10                  15      


Gln Gly Gly Arg Ser Arg Ser Leu Ser Thr Phe Asn Leu Asn Leu Tyr 
            20                  25                  30          


His Pro Leu Lys Lys Thr Pro Phe Ser Ile Gln Thr Pro Lys Gln Lys 
        35                  40                  45              


Arg Pro Thr Ser Pro Phe Ser Ser Ile Ser Ala Val Leu Thr Glu Gln 
    50                  55                  60                  


Glu Ala Val Lys Glu Gly Asp Glu Glu Lys Ser Ile Phe Asn Phe Lys 
65                  70                  75                  80  


Ser Tyr Met Val Gln Lys Ala Asn Ser Val Asn Gln Ala Leu Asp Ser 
                85                  90                  95      


Ala Val Leu Leu Arg Asp Pro Ile Met Ile His Glu Ser Met Arg Tyr 
            100                 105                 110         


Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro Met Leu Cys Leu Ser 
        115                 120                 125             


Ala Cys Glu Leu Val Gly Gly Lys Glu Ser Val Ala Met Pro Ala Ala 
    130                 135                 140                 


Cys Ala Val Glu Met Ile His Thr Met Ser Leu Ile His Asp Asp Leu 
145                 150                 155                 160 


Pro Cys Met Asp Asn Asp Asp Leu Arg Arg Gly Lys Pro Thr Asn His 
                165                 170                 175     


Lys Val Phe Gly Glu Asp Val Ala Val Leu Ala Gly Asp Ala Leu Leu 
            180                 185                 190         


Ala Phe Ala Phe Glu His Met Ala Val Ser Thr Val Gly Val Pro Ala 
        195                 200                 205             


Ala Lys Ile Val Arg Ala Ile Gly Glu Leu Ala Lys Ser Ile Gly Ser 
    210                 215                 220                 


Glu Gly Leu Val Ala Gly Gln Val Val Asp Ile Asp Ser Glu Gly Leu 
225                 230                 235                 240 


Ala Asn Val Gly Leu Glu Gln Leu Glu Phe Ile His Leu His Lys Thr 
                245                 250                 255     


Gly Ala Leu Leu Glu Ala Ser Val Val Leu Gly Ala Ile Leu Gly Gly 
            260                 265                 270         


Gly Thr Asp Glu Glu Val Glu Lys Leu Arg Ser Phe Ala Arg Cys Ile 
        275                 280                 285             


Gly Leu Leu Phe Gln Val Val Asp Asp Ile Leu Asp Val Thr Lys Ser 
    290                 295                 300                 


Ser Gln Glu Leu Gly Lys Thr Ala Gly Lys Asp Leu Val Ala Asp Lys 
305                 310                 315                 320 


Val Thr Tyr Pro Arg Leu Met Gly Ile Asp Lys Ser Arg Glu Phe Ala 
                325                 330                 335     


Glu Gln Leu Asn Thr Glu Ala Lys Gln His Leu Ser Gly Phe Asp Pro 
            340                 345                 350         


Ile Lys Ala Ala Pro Leu Ile Ala Leu Ala Asn Tyr Ile Ala Tyr Arg 
        355                 360                 365             


Gln Asn 
    370 


<210>  73
<211>  948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial geranylgeranyl pyrophosphate synthase small subunit 
       (GPPSssu) nucleotide sequence

<400>  73
atggctgttt acaacctttc aatcaactgt tctcccagat tcgtccatca tgtatacgtg       60

ccccatttta catgtaaatc aaataagagc ctgagccatg tccccatgag aatcacgatg      120

tcaaagcagc atcatcactc atactttgcc tctacaacgg cagatgtcga tgcccatcta      180

aaacaatcaa tcacaattaa acccccgttg tctgtccacg aagccatgta taactttatc      240

ttcagtacgc caccgaattt ggcgccatca ttatgtgtcg cagcatgtga attggttggg      300

ggtcaccagg gacaggcgat ggcagcggcc agcgcattaa gggtaataca tgctagcatc      360

gttacccacg atcaccttcc gttaacggga aggccaaacc ccacctcacc ggaggccgct      420

acgcacaatt cctataatcc aaacatacag ttgttattac ctgacgccat tacacccttc      480

gggtttgagc tattagcgtc cagtgatgat cttacacaca acaagagtga gagagttctt      540

agggtgatcg ttgaatttac gaggactttc ggttccagag gcactataga cgcccaatac      600

cacgaaaagt tggctagtag gtttgatgtg gatagccatg aggcaaagac cgtaggatgg      660

gggcattacc catcattgaa aaaggaggga gccatgcacg catgtgctgc tgcctgcgga      720

gcaatattgg gtgaggctca tgaagaagaa gtggaaaaat tgcgtacatt cgggctgtat      780

gtcggcatga tccaaggtta tgcgaacaga ttcatcatga gcagtacaga ggagaaaaaa      840

gaggctgaca ggataattga ggagcttacc aatttagcgc gtcaggagct gaaatacttc      900

gatggaagga acctagaacc gttttcaaca ttcttgttcc gtttgtag                   948


<210>  74
<211>  315
<212>  PRT
<213>  Cannabis sativa

<400>  74

Met Ala Val Tyr Asn Leu Ser Ile Asn Cys Ser Pro Arg Phe Val His 
1               5                   10                  15      


His Val Tyr Val Pro His Phe Thr Cys Lys Ser Asn Lys Ser Leu Ser 
            20                  25                  30          


His Val Pro Met Arg Ile Thr Met Ser Lys Gln His His His Ser Tyr 
        35                  40                  45              


Phe Ala Ser Thr Thr Ala Asp Val Asp Ala His Leu Lys Gln Ser Ile 
    50                  55                  60                  


Thr Ile Lys Pro Pro Leu Ser Val His Glu Ala Met Tyr Asn Phe Ile 
65                  70                  75                  80  


Phe Ser Thr Pro Pro Asn Leu Ala Pro Ser Leu Cys Val Ala Ala Cys 
                85                  90                  95      


Glu Leu Val Gly Gly His Gln Gly Gln Ala Met Ala Ala Ala Ser Ala 
            100                 105                 110         


Leu Arg Val Ile His Ala Ser Ile Val Thr His Asp His Leu Pro Leu 
        115                 120                 125             


Thr Gly Arg Pro Asn Pro Thr Ser Pro Glu Ala Ala Thr His Asn Ser 
    130                 135                 140                 


Tyr Asn Pro Asn Ile Gln Leu Leu Leu Pro Asp Ala Ile Thr Pro Phe 
145                 150                 155                 160 


Gly Phe Glu Leu Leu Ala Ser Ser Asp Asp Leu Thr His Asn Lys Ser 
                165                 170                 175     


Glu Arg Val Leu Arg Val Ile Val Glu Phe Thr Arg Thr Phe Gly Ser 
            180                 185                 190         


Arg Gly Thr Ile Asp Ala Gln Tyr His Glu Lys Leu Ala Ser Arg Phe 
        195                 200                 205             


Asp Val Asp Ser His Glu Ala Lys Thr Val Gly Trp Gly His Tyr Pro 
    210                 215                 220                 


Ser Leu Lys Lys Glu Gly Ala Met His Ala Cys Ala Ala Ala Cys Gly 
225                 230                 235                 240 


Ala Ile Leu Gly Glu Ala His Glu Glu Glu Val Glu Lys Leu Arg Thr 
                245                 250                 255     


Phe Gly Leu Tyr Val Gly Met Ile Gln Gly Tyr Ala Asn Arg Phe Ile 
            260                 265                 270         


Met Ser Ser Thr Glu Glu Lys Lys Glu Ala Asp Arg Ile Ile Glu Glu 
        275                 280                 285             


Leu Thr Asn Leu Ala Arg Gln Glu Leu Lys Tyr Phe Asp Gly Arg Asn 
    290                 295                 300                 


Leu Glu Pro Phe Ser Thr Phe Leu Phe Arg Leu 
305                 310                 315 


<210>  75
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial tetraketide synthase (TKS) nucleotide sequence

<400>  75
atgaatcatt taagagctga aggtccagcc tccgttttgg ccatcggtac cgctaaccct       60

gaaaacattt tgttgcaaga cgaattccca gactactact tcagagtcac taagtccgaa      120

cacatgaccc aattgaagga gaagttcaga aagatttgtg acaagtccat gattagaaag      180

agaaactgtt tcttgaacga agaacacttg aagcaaaacc caagattggt tgaacatgaa      240

atgcaaactt tggacgctag acaagacatg ttggttgttg aagtccctaa gttgggtaag      300

gatgcctgtg ctaaggccat taaagaatgg ggtcaaccta agtccaagat tacccacttg      360

attttcacct ctgcctccac cactgacatg cctggtgctg attaccactg cgctaagtta      420

ttgggtttgt ctccatccgt taagagagtt atgatgtacc aattgggttg ctacggtggt      480

ggtactgttt taagaattgc taaggatatt gctgaaaaca acaagggtgc cagagtctta      540

gctgtctgct gtgacattat ggcttgttta ttcagaggtc catctgaatc cgacttggaa      600

ttgttggttg gtcaagctat cttcggtgac ggtgctgctg ccgttattgt tggtgctgaa      660

ccagacgaat ccgttggtga aagaccaatt tttgaattgg tttccaccgg tcaaactatt      720

ttgccaaatt ccgaaggtac catcggtggt catatcagag aagccggttt gatcttcgac      780

ttacataagg atgtcccaat gttgatctct aacaacattg aaaagtgttt gatcgaagct      840

tttaccccaa ttggtatttc tgactggaac tctatcttct ggattaccca tcctggtggt      900

aaggctattt tggataaggt cgaggaaaaa ttgcacttga agtctgacaa gttcgttgac      960

tctagacacg tcttgtccga acatggtaat atgtcctctt ccaccgtttt attcgttatg     1020

gatgagttga gaaagagatc cttagaagaa ggtaagtcca ccaccggtga tggttttgag     1080

tggggtgttt tgttcggttt cggtccaggt ttgaccgtcg aaagagttgt tgttagatct     1140

gtcccaatta agtacggatc c                                               1161


<210>  76
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial tetraketide synthase (TKS)

<400>  76

Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr Gly Ser 
385         


<210>  77
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial olivetolic acid cyclase (OAC) nucleotide sequence

<400>  77
atggccgtca agcacttgat cgttttgaag ttcaaggatg aaatcactga agctcaaaag       60

gaagaattct tcaaaaccta cgtcaactta gtcaatatta ttccagccat gaaggacgtc      120

tattggggta aggacgttac tcaaaagaat aaggaggaag gttatactca tatcgttgag      180

gtcactttcg aatctgttga gactattcaa gactacatca tccacccagc ccacgttggt      240

ttcggtgatg tttatcgttc cttctgggaa aaattgttga tcttcgacta cacccctaga      300

aagggatcc                                                              309


<210>  78
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial olivetolic acid cyclase (OAC)

<400>  78

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys Gly Ser 
            100             


<210>  79
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion tetraketide synthase-olivetolic acid cyclase (TKS-OAC)

<400>  79
atgaatcatt taagagctga aggtccagcc tccgttttgg ccatcggtac cgctaaccct       60

gaaaacattt tgttgcaaga cgaattccca gactactact tcagagtcac taagtccgaa      120

cacatgaccc aattgaagga gaagttcaga aagatttgtg acaagtccat gattagaaag      180

agaaactgtt tcttgaacga agaacacttg aagcaaaacc caagattggt tgaacatgaa      240

atgcaaactt tggacgctag acaagacatg ttggttgttg aagtccctaa gttgggtaag      300

gatgcctgtg ctaaggccat taaagaatgg ggtcaaccta agtccaagat tacccacttg      360

attttcacct ctgcctccac cactgacatg cctggtgctg attaccactg cgctaagtta      420

ttgggtttgt ctccatccgt taagagagtt atgatgtacc aattgggttg ctacggtggt      480

ggtactgttt taagaattgc taaggatatt gctgaaaaca acaagggtgc cagagtctta      540

gctgtctgct gtgacattat ggcttgttta ttcagaggtc catctgaatc cgacttggaa      600

ttgttggttg gtcaagctat cttcggtgac ggtgctgctg ccgttattgt tggtgctgaa      660

ccagacgaat ccgttggtga aagaccaatt tttgaattgg tttccaccgg tcaaactatt      720

ttgccaaatt ccgaaggtac catcggtggt catatcagag aagccggttt gatcttcgac      780

ttacataagg atgtcccaat gttgatctct aacaacattg aaaagtgttt gatcgaagct      840

tttaccccaa ttggtatttc tgactggaac tctatcttct ggattaccca tcctggtggt      900

aaggctattt tggataaggt cgaggaaaaa ttgcacttga agtctgacaa gttcgttgac      960

tctagacacg tcttgtccga acatggtaat atgtcctctt ccaccgtttt attcgttatg     1020

gatgagttga gaaagagatc cttagaagaa ggtaagtcca ccaccggtga tggttttgag     1080

tggggtgttt tgttcggttt cggtccaggt ttgaccgtcg aaagagttgt tgttagatct     1140

gtcccaatta agtacgcagc cacaagcggt tctacgggct ccacgggctc taccggcagt     1200

gggaggagca ctgggtcaac gggatcaaca ggtagtggaa gatcacacat ggttgccgtc     1260

aagcacttga tcgttttgaa gttcaaggat gaaatcactg aagctcaaaa ggaagaattc     1320

ttcaaaacct acgtcaactt agtcaatatt attccagcca tgaaggacgt ctattggggt     1380

aaggacgtta ctcaaaagaa taaggaggaa ggttatactc atatcgttga ggtcactttc     1440

gaatctgttg agactattca agactacatc atccacccag cccacgttgg tttcggtgat     1500

gtttatcgtt ccttctggga aaaattgttg atcttcgact acacccctag aaagggtaac     1560

tcgagagctt ttgattaa                                                   1578


<210>  80
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion tetraketide synthase-olivetolic acid cyclase (TKS-OAC)

<400>  80

Met Asn His Leu Arg Ala Glu Gly Pro Ala Ser Val Leu Ala Ile Gly 
1               5                   10                  15      


Thr Ala Asn Pro Glu Asn Ile Leu Leu Gln Asp Glu Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Phe Arg Val Thr Lys Ser Glu His Met Thr Gln Leu Lys Glu Lys 
        35                  40                  45              


Phe Arg Lys Ile Cys Asp Lys Ser Met Ile Arg Lys Arg Asn Cys Phe 
    50                  55                  60                  


Leu Asn Glu Glu His Leu Lys Gln Asn Pro Arg Leu Val Glu His Glu 
65                  70                  75                  80  


Met Gln Thr Leu Asp Ala Arg Gln Asp Met Leu Val Val Glu Val Pro 
                85                  90                  95      


Lys Leu Gly Lys Asp Ala Cys Ala Lys Ala Ile Lys Glu Trp Gly Gln 
            100                 105                 110         


Pro Lys Ser Lys Ile Thr His Leu Ile Phe Thr Ser Ala Ser Thr Thr 
        115                 120                 125             


Asp Met Pro Gly Ala Asp Tyr His Cys Ala Lys Leu Leu Gly Leu Ser 
    130                 135                 140                 


Pro Ser Val Lys Arg Val Met Met Tyr Gln Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Gly Thr Val Leu Arg Ile Ala Lys Asp Ile Ala Glu Asn Asn Lys Gly 
                165                 170                 175     


Ala Arg Val Leu Ala Val Cys Cys Asp Ile Met Ala Cys Leu Phe Arg 
            180                 185                 190         


Gly Pro Ser Glu Ser Asp Leu Glu Leu Leu Val Gly Gln Ala Ile Phe 
        195                 200                 205             


Gly Asp Gly Ala Ala Ala Val Ile Val Gly Ala Glu Pro Asp Glu Ser 
    210                 215                 220                 


Val Gly Glu Arg Pro Ile Phe Glu Leu Val Ser Thr Gly Gln Thr Ile 
225                 230                 235                 240 


Leu Pro Asn Ser Glu Gly Thr Ile Gly Gly His Ile Arg Glu Ala Gly 
                245                 250                 255     


Leu Ile Phe Asp Leu His Lys Asp Val Pro Met Leu Ile Ser Asn Asn 
            260                 265                 270         


Ile Glu Lys Cys Leu Ile Glu Ala Phe Thr Pro Ile Gly Ile Ser Asp 
        275                 280                 285             


Trp Asn Ser Ile Phe Trp Ile Thr His Pro Gly Gly Lys Ala Ile Leu 
    290                 295                 300                 


Asp Lys Val Glu Glu Lys Leu His Leu Lys Ser Asp Lys Phe Val Asp 
305                 310                 315                 320 


Ser Arg His Val Leu Ser Glu His Gly Asn Met Ser Ser Ser Thr Val 
                325                 330                 335     


Leu Phe Val Met Asp Glu Leu Arg Lys Arg Ser Leu Glu Glu Gly Lys 
            340                 345                 350         


Ser Thr Thr Gly Asp Gly Phe Glu Trp Gly Val Leu Phe Gly Phe Gly 
        355                 360                 365             


Pro Gly Leu Thr Val Glu Arg Val Val Val Arg Ser Val Pro Ile Lys 
    370                 375                 380                 


Tyr Ala Ala Thr Ser Gly Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser 
385                 390                 395                 400 


Gly Arg Ser Thr Gly Ser Thr Gly Ser Thr Gly Ser Gly Arg Ser His 
                405                 410                 415     


Met Val Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile 
            420                 425                 430         


Thr Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val 
        435                 440                 445             


Asn Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr 
    450                 455                 460                 


Gln Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe 
465                 470                 475                 480 


Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val 
                485                 490                 495     


Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe 
            500                 505                 510         


Asp Tyr Thr Pro Arg Lys Gly Asn Ser Arg Ala Phe Asp 
        515                 520                 525 


<210>  81
<211>  1185
<212>  DNA
<213>  Cannabis sativa

<400>  81
atgggattgt ccagcgtgtg caccttctca ttccaaacca actaccatac acttctcaat       60

ccgcacaata ataacccgaa aaccagctta ttatgttata gacacccgaa gacgcctatt      120

aagtacagtt ataacaactt tcctagcaag cattgctcta ctaaaagttt tcatctgcaa      180

aacaagtgct ctgagtcctt gagtatagca aagaatagca ttagagctgc aacgacaaat      240

caaaccgagc cgccggagtc tgataaccat agtgtggcga ccaagatact aaattttggc      300

aaagcgtgtt ggaagctaca acgaccttat actattatcg cgtttacgag ttgtgcatgt      360

gggctgttcg ggaaagagct cttgcacaat acaaacttaa tcagttggag tttgatgttc      420

aaagcatttt tttttctcgt cgctatctta tgtatcgcgt catttaccac gaccataaat      480

caaatatacg atctgcatat cgatcgtatc aataagcccg acctcccact ggcctcaggt      540

gaaatttccg ttaacacggc gtggattatg agtataatcg tagcactatt tggacttatt      600

ataaccatca aaatgaaggg cggtcctcta tacatttttg gatattgttt tgggattttt      660

ggaggtatag tctattccgt ccccccattc agatggaaac aaaacccgtc caccgctttc      720

cttttaaatt tcttggcaca tatcatcaca aacttcacgt tttactatgc cagccgagcc      780

gcactgggac tcccgttcga gttgcgtccg tcattcacct tccttttagc ttttatgaaa      840

tctatgggaa gcgctttagc tttaattaag gacgcgagcg acgtggaagg ggacacgaaa      900

ttcggtataa gcacgctggc ttcaaaatat ggaagtcgta atctcactct attttgttct      960

gggattgtac tcctaagtta cgtagctgcg atactcgcag gcattatatg gccacaagct     1020

ttcaactcca acgtaatgtt gctatcacat gcaatcttgg ccttctggct catccttcaa     1080

actagagatt ttgcactaac gaactacgat ccagaagcgg gtcgtcgatt ttacgaattt     1140

atgtggaaac tgtactatgc tgagtacctc gtctatgtgt tcata                     1185


<210>  82
<211>  395
<212>  PRT
<213>  Cannabis sativa

<400>  82

Met Gly Leu Ser Ser Val Cys Thr Phe Ser Phe Gln Thr Asn Tyr His 
1               5                   10                  15      


Thr Leu Leu Asn Pro His Asn Asn Asn Pro Lys Thr Ser Leu Leu Cys 
            20                  25                  30          


Tyr Arg His Pro Lys Thr Pro Ile Lys Tyr Ser Tyr Asn Asn Phe Pro 
        35                  40                  45              


Ser Lys His Cys Ser Thr Lys Ser Phe His Leu Gln Asn Lys Cys Ser 
    50                  55                  60                  


Glu Ser Leu Ser Ile Ala Lys Asn Ser Ile Arg Ala Ala Thr Thr Asn 
65                  70                  75                  80  


Gln Thr Glu Pro Pro Glu Ser Asp Asn His Ser Val Ala Thr Lys Ile 
                85                  90                  95      


Leu Asn Phe Gly Lys Ala Cys Trp Lys Leu Gln Arg Pro Tyr Thr Ile 
            100                 105                 110         


Ile Ala Phe Thr Ser Cys Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu 
        115                 120                 125             


His Asn Thr Asn Leu Ile Ser Trp Ser Leu Met Phe Lys Ala Phe Phe 
    130                 135                 140                 


Phe Leu Val Ala Ile Leu Cys Ile Ala Ser Phe Thr Thr Thr Ile Asn 
145                 150                 155                 160 


Gln Ile Tyr Asp Leu His Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
                165                 170                 175     


Leu Ala Ser Gly Glu Ile Ser Val Asn Thr Ala Trp Ile Met Ser Ile 
            180                 185                 190         


Ile Val Ala Leu Phe Gly Leu Ile Ile Thr Ile Lys Met Lys Gly Gly 
        195                 200                 205             


Pro Leu Tyr Ile Phe Gly Tyr Cys Phe Gly Ile Phe Gly Gly Ile Val 
    210                 215                 220                 


Tyr Ser Val Pro Pro Phe Arg Trp Lys Gln Asn Pro Ser Thr Ala Phe 
225                 230                 235                 240 


Leu Leu Asn Phe Leu Ala His Ile Ile Thr Asn Phe Thr Phe Tyr Tyr 
                245                 250                 255     


Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe 
            260                 265                 270         


Thr Phe Leu Leu Ala Phe Met Lys Ser Met Gly Ser Ala Leu Ala Leu 
        275                 280                 285             


Ile Lys Asp Ala Ser Asp Val Glu Gly Asp Thr Lys Phe Gly Ile Ser 
    290                 295                 300                 


Thr Leu Ala Ser Lys Tyr Gly Ser Arg Asn Leu Thr Leu Phe Cys Ser 
305                 310                 315                 320 


Gly Ile Val Leu Leu Ser Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile 
                325                 330                 335     


Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser His Ala Ile 
            340                 345                 350         


Leu Ala Phe Trp Leu Ile Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn 
        355                 360                 365             


Tyr Asp Pro Glu Ala Gly Arg Arg Phe Tyr Glu Phe Met Trp Lys Leu 
    370                 375                 380                 


Tyr Tyr Ala Glu Tyr Leu Val Tyr Val Phe Ile 
385                 390                 395 


<210>  83
<211>  921
<212>  DNA
<213>  Streptomyces sp.

<400>  83
atgtctgagg cggcagacgt agagagagta tacgctgcta tggaggaagc ggctggatta       60

ttgggggtgg cttgtgccag agacaagata tatccgttac tgtctacttt ccaggacact      120

cttgtagaag gagggagtgt ggtggtgttt agtatggcat caggccgtca ttcaacagag      180

ctagatttca gtatatctgt gccaacaagt cacggtgatc catacgcaac cgtagtcgag      240

aagggtcttt tcccggcaac agggcatcct gtagatgatt tgcttgccga cacacagaag      300

cacctgcccg tctccatgtt cgcaatcgat ggtgaggtga ccggaggatt taaaaagact      360

tacgctttct tcccgactga caatatgcca ggagttgccg agttgagtgc aataccatcc      420

atgccgccag cagtcgcgga gaacgccgaa ttgttcgccc gttacggctt ggacaaagtc      480

caaatgacta gtatggacta taaaaagagg caggtgaatc tatatttcag cgaactttct      540

gcccaaacct tggaggcgga gagcgtttta gcccttgtta gggagttagg gctacacgtc      600

ccgaatgagt tgggtttgaa attttgtaag cgtagctttt cagtatatcc gacgctgaac      660

tgggaaactg gaaagattga caggctatgc tttgcagtga tttctaatga ccctacgctt      720

gtaccttcct cagacgaggg cgacatcgag aaattccaca actatgccac aaaagctccg      780

tatgcctacg tcggcgaaaa acgtactcta gtatacggtt tgactctgag tcccaaggaa      840

gagtattaca agctaggagc gtactatcat atcactgatg tgcaacgtgg cttgctgaaa      900

gccttcgact ccttagagga c                                                921


<210>  84
<211>  307
<212>  PRT
<213>  Streptomyces sp.

<400>  84

Met Ser Glu Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Gly Val Ala Cys Ala Arg Asp Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Ser Thr Phe Gln Asp Thr Leu Val Glu Gly Gly Ser Val Val 
        35                  40                  45              


Val Phe Ser Met Ala Ser Gly Arg His Ser Thr Glu Leu Asp Phe Ser 
    50                  55                  60                  


Ile Ser Val Pro Thr Ser His Gly Asp Pro Tyr Ala Thr Val Val Glu 
65                  70                  75                  80  


Lys Gly Leu Phe Pro Ala Thr Gly His Pro Val Asp Asp Leu Leu Ala 
                85                  90                  95      


Asp Thr Gln Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu 
            100                 105                 110         


Val Thr Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asn 
        115                 120                 125             


Met Pro Gly Val Ala Glu Leu Ser Ala Ile Pro Ser Met Pro Pro Ala 
    130                 135                 140                 


Val Ala Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val 
145                 150                 155                 160 


Gln Met Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe 
                165                 170                 175     


Ser Glu Leu Ser Ala Gln Thr Leu Glu Ala Glu Ser Val Leu Ala Leu 
            180                 185                 190         


Val Arg Glu Leu Gly Leu His Val Pro Asn Glu Leu Gly Leu Lys Phe 
        195                 200                 205             


Cys Lys Arg Ser Phe Ser Val Tyr Pro Thr Leu Asn Trp Glu Thr Gly 
    210                 215                 220                 


Lys Ile Asp Arg Leu Cys Phe Ala Val Ile Ser Asn Asp Pro Thr Leu 
225                 230                 235                 240 


Val Pro Ser Ser Asp Glu Gly Asp Ile Glu Lys Phe His Asn Tyr Ala 
                245                 250                 255     


Thr Lys Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr 
            260                 265                 270         


Gly Leu Thr Leu Ser Pro Lys Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr 
        275                 280                 285             


Tyr His Ile Thr Asp Val Gln Arg Gly Leu Leu Lys Ala Phe Asp Ser 
    290                 295                 300                 


Leu Glu Asp 
305         


<210>  85
<211>  1635
<212>  DNA
<213>  Cannabis sativa

<400>  85
atgaactgtt ccgcgtttag tttctggttc gtgtgcaaga tcatcttctt ttttctaagc       60

ttcaacattc aaatcagcat cgcgaatcct caggagaact tcctgaagtg tttctcagaa      120

tacataccaa ataatcccgc caatcctaaa tttatatata cccaacatga tcagctatac      180

atgagtgtat tgaactctac gattcagaat ctaagattca catctgatac aacgccgaaa      240

cctctagtaa tcgtgacacc gtctaatgtc tcccatattc aagcttctat cttgtgctca      300

aagaaagtcg gtcttcaaat aaggacacgt tctggcgggc atgacgccga gggcatgtca      360

tatatcagcc aagtaccatt tgtagtcgtg gatttaagaa acatgcattc tataaaaatc      420

gacgttcact cccaaacggc atgggtggaa gctggagcga cactggggga ggtgtactac      480

tggatcaatg aaaagaacga aaatttttcc ttccccggag gatattgtcc gacagttggg      540

gtggggggcc acttctctgg cggcgggtac ggcgctctga tgcgtaatta tggactggcc      600

gcagataaca taatcgacgc gcatttggtg aacgttgacg ggaaggtttt ggataggaag      660

tctatgggag aggacctatt ctgggcaatt agaggcggag gaggagagaa ttttggtatt      720

attgctgcat ggaagattaa attggttgcg gtgccgagta aaagtaccat cttttccgtc      780

aagaaaaaca tggagattca cggactagtt aagctgttta ataaatggca aaacatcgcc      840

tataagtacg acaaagattt ggttctgatg acgcatttca taactaagaa tataactgat      900

aatcacggca agaataagac cactgtgcac ggttatttta gttcaatatt ccatggcggc      960

gttgactccc ttgtcgattt gatgaataag agcttccctg aattgggtat caagaagaca     1020

gactgcaaag aattctcctg gattgatacg actatcttct attcaggggt cgtgaatttc     1080

aacactgcga atttcaaaaa ggagatattg ttagaccgtt ccgcgggaaa aaaaactgcg     1140

ttttctatta aactagatta tgtgaaaaaa ccgattcctg agacagccat ggttaagatt     1200

cttgaaaaat tgtatgaaga ggatgtcggg gtcggtatgt acgtccttta cccttacgga     1260

ggaatcatgg aagaaatatc cgaatctgca attcctttcc cgcatcgtgc cggtattatg     1320

tatgagctat ggtacaccgc tagctgggag aagcaggaag ataacgagaa gcatatcaat     1380

tgggtgaggt ctgtgtataa ttttacaaca ccatacgtca gtcaaaaccc tagattggcc     1440

tatcttaact atcgtgatct ggacttggga aaaacaaatc cagaatcccc aaataactac     1500

actcaagccc gtatatgggg cgagaagtac ttcggcaaaa atttcaatag actggtcaaa     1560

gttaagacga aagcagaccc taataatttc ttccgtaacg aacaatcaat tcccccgctt     1620

ccgccacacc atcac                                                      1635


<210>  86
<211>  545
<212>  PRT
<213>  Cannabis sativa

<400>  86

Met Asn Cys Ser Ala Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Leu Ser Phe Asn Ile Gln Ile Ser Ile Ala Asn Pro Gln Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Glu Tyr Ile Pro Asn Asn Pro Ala Asn 
        35                  40                  45              


Pro Lys Phe Ile Tyr Thr Gln His Asp Gln Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile Gln Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser Asn Val Ser His Ile Gln Ala Ser 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Val Val Asp Leu Arg Asn Met His Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Ile Asn Glu Lys Asn Glu Asn Phe Ser Phe Pro Gly Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Gly Val Gly Gly His Phe Ser Gly Gly Gly Tyr Gly Ala 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly Glu Asn Phe Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val Pro Ser Lys Ser Thr 
                245                 250                 255     


Ile Phe Ser Val Lys Lys Asn Met Glu Ile His Gly Leu Val Lys Leu 
            260                 265                 270         


Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Val 
        275                 280                 285             


Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr Asp Asn His Gly Lys 
    290                 295                 300                 


Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser Ile Phe His Gly Gly 
305                 310                 315                 320 


Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly 
                325                 330                 335     


Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp Ile Asp Thr Thr Ile 
            340                 345                 350         


Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala Asn Phe Lys Lys Glu 
        355                 360                 365             


Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr Ala Phe Ser Ile Lys 
    370                 375                 380                 


Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr Ala Met Val Lys Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Val Gly Met Tyr Val Leu 
                405                 410                 415     


Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser Glu Ser Ala Ile Pro 
            420                 425                 430         


Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Thr Ala Ser 
        435                 440                 445             


Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile Asn Trp Val Arg Ser 
    450                 455                 460                 


Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln Asn Pro Arg Leu Ala 
465                 470                 475                 480 


Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys Thr Asn Pro Glu Ser 
                485                 490                 495     


Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly 
            500                 505                 510         


Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr Lys Ala Asp Pro Asn 
        515                 520                 525             


Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Pro His His 
    530                 535                 540                 


His 
545 


<210>  87
<211>  1632
<212>  DNA
<213>  Cannabis sativa

<400>  87
atgaaatgtt ctactttcag tttttggttc gtgtgtaaga tcatcttttt ctttttcagc       60

ttcaatatac agacaagtat cgccaatcca agagaaaatt tcttaaaatg tttttcacag      120

tacatcccta ataacgccac taacctgaaa ttagtgtaca cccaaaataa tcctctttat      180

atgtctgttt taaactccac gatccataat ttaaggttta catcagatac gacaccaaag      240

cccttggtaa tcgtgactcc cagccacgtg agccacatac aggggaccat cctgtgctct      300

aagaaagtag gcttgcagat caggacaaga tccggtggac acgacagtga gggaatgtcc      360

tatatttcac aagtcccctt cgttatagta gatctgagga acatgaggtc cattaagatt      420

gatgtgcact cacaaacggc ttgggttgaa gctggagcca cattgggaga ggtttattac      480

tgggtgaatg agaagaacga gaacctttca ttagcagcgg gatattgtcc cacggtgtgc      540

gcaggtgggc atttcggggg aggagggtac ggccctttga tgagaaatta cgggctagcg      600

gcagacaaca tcatcgacgc ccatctggtg aacgtgcatg gaaaagtact ggacagaaag      660

tcaatgggcg aggacctgtt ttgggctttg agagggggcg gtgcagagtc atttggcatc      720

atagttgcat ggaaaatcag acttgttgcc gtcccaaagt ccacaatgtt ctctgttaag      780

aaaatcatgg agatacacga attggtgaaa ttagtgaata aatggcaaaa catagcgtac      840

aagtacgaca aagacttact gctgatgaca cactttatca cccgtaatat tacagataat      900

cagggtaaga acaaaaccgc gatccataca tatttttcat ccgtttttct aggcggtgtc      960

gattcattag tagatctgat gaacaaatct ttccccgaac ttggtatcaa aaagactgat     1020

tgcagacagt tatcatggat tgatacaata attttctatt ctggtgtcgt aaattacgat     1080

accgataatt ttaataagga aatactatta gatcgttccg ctgggcagaa tggtgcattc     1140

aagataaaac ttgattatgt caaaaagccc attccagaga gtgtctttgt gcagatcctt     1200

gagaagttgt atgaagaaga cattggtgca gggatgtacg cgctatatcc gtacgggggt     1260

attatggacg agatttctga gagcgccata ccattcccac acagagcagg aattttatac     1320

gagttatggt atatctgctc atgggaaaaa caggaagaca acgagaagca cttaaactgg     1380

atacgtaata tctataattt tatgacccca tacgtatcaa aaaatccgcg tcttgcgtac     1440

cttaactaca gggacctgga cataggtata aacgacccaa aaaatcccaa taattacacc     1500

caagctagaa tctgggggga gaagtatttc ggtaagaact ttgaccgttt ggtaaaagtc     1560

aaaactctgg tcgatccgaa caatttcttc cgtaacgagc aatccatacc tccgctaccg     1620

agacatagac at                                                         1632


<210>  88
<211>  544
<212>  PRT
<213>  Cannabis sativa

<400>  88

Met Lys Cys Ser Thr Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Phe Ser Phe Asn Ile Gln Thr Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn Asn Ala Thr Asn 
        35                  40                  45              


Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr Met Ser Val Leu 
    50                  55                  60                  


Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser His Val Ser His Ile Gln Gly Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala Ala Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly Gly Tyr Gly Pro 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu Ser Phe Gly Ile 
225                 230                 235                 240 


Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro Lys Ser Thr Met 
                245                 250                 255     


Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu Val Lys Leu Val 
            260                 265                 270         


Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Leu Leu 
        275                 280                 285             


Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn Gln Gly Lys Asn 
    290                 295                 300                 


Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe Leu Gly Gly Val 
305                 310                 315                 320 


Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly Ile 
                325                 330                 335     


Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp Thr Ile Ile Phe 
            340                 345                 350         


Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe Asn Lys Glu Ile 
        355                 360                 365             


Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe Lys Ile Lys Leu 
    370                 375                 380                 


Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe Val Gln Ile Leu 
385                 390                 395                 400 


Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met Tyr Ala Leu Tyr 
                405                 410                 415     


Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser Ala Ile Pro Phe 
            420                 425                 430         


Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr Ile Cys Ser Trp 
        435                 440                 445             


Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp Ile Arg Asn Ile 
    450                 455                 460                 


Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro Arg Leu Ala Tyr 
465                 470                 475                 480 


Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp Pro Lys Asn Pro 
                485                 490                 495     


Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly Lys 
            500                 505                 510         


Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val Asp Pro Asn Asn 
        515                 520                 525             


Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Arg His Arg His 
    530                 535                 540                 


<210>  89
<211>  2160
<212>  DNA
<213>  Cannabis sativa

<400>  89
atgggaaaaa actacaaaag tctggactcc gtcgtcgcgt cagacttcat tgccctaggc       60

ataacatcag aggtagcgga aaccttacac ggcagactag ccgagattgt ttgtaactac      120

ggggcggcta ctccccagac ttggatcaat atagccaatc acatattaag ccccgatttg      180

ccgttttccc ttcaccaaat gttgttctac ggctgctata aggactttgg accagcgccc      240

cccgcgtgga ttcctgatcc ggagaaagtt aaatccacga atcttggggc attactagaa      300

aaacgtggca aagaattcct aggagttaaa tataaggacc ccatatcttc cttttcacac      360

tttcaagaat tttcagttag aaacccagag gtttactgga ggacagtatt aatggatgag      420

atgaagataa gctttagtaa ggatccggag tgtattctgc gtagagatga cattaacaat      480

cctggcggaa gtgaatggct gcctggtggg tacctgaata gtgctaagaa ctgtttaaac      540

gtcaactcta ataaaaaatt gaatgataca atgattgtat ggagagacga agggaacgat      600

gacctaccat tgaacaagct gactctagat cagctacgta aacgtgtatg gttggtcggg      660

tacgcgctgg aggagatggg attagaaaaa ggatgcgcaa ttgctatcga catgcctatg      720

catgtggacg cggtagtcat ttacttggcc attgtcctag cgggttacgt cgtcgtttca      780

attgcagaca gcttttctgc acccgaaatc agtacccgtc tgcgtttgtc taaagctaag      840

gcaatattta cccaagacca tataattaga ggcaagaagc gtataccgtt gtacagtagg      900

gttgtagagg caaagtcacc catggctatt gtgataccat gctctggctc taatatagga      960

gcggagctta gagatggtga catctcctgg gattactttc ttgaacgtgc taaggagttt     1020

aaaaactgtg aatttactgc aagagagcag cccgtggatg catacacaaa catattgttc     1080

tccagcggta ctacgggaga acctaaagca ataccttgga cacaagctac accccttaaa     1140

gcggccgctg acggatggtc ccacctggat atcaggaagg gtgacgtcat agtttggccg     1200

actaacctgg gatggatgat gggcccttgg ctggtttacg ctagccttct gaatggggcc     1260

agcattgcat tgtacaatgg ctcaccgctt gtatcaggct tcgcgaagtt cgtacaggac     1320

gccaaggtaa caatgctagg cgtagttccg tccatagtta ggtcttggaa gagcacgaac     1380

tgcgttagtg gctacgattg gagcactatt cgttgtttca gctcttctgg cgaggccagc     1440

aacgttgatg aatatttgtg gttgatgggg agagcgaact acaaacctgt tattgagatg     1500

tgcggcggaa ctgagattgg gggagcattc tccgccggtt cttttctaca agcccaaagt     1560

ttatcctctt ttagcagcca gtgcatgggc tgtacactat acattctgga caaaaatggt     1620

tatccgatgc cgaaaaacaa gcccggcatc ggagaactgg ccctaggacc cgtgatgttc     1680

ggcgctagta agacgttgtt gaatgggaat caccacgacg tttattttaa gggaatgcca     1740

actttgaatg gcgaagtact tcgtagacac ggagacatct ttgagttgac ttcaaacggt     1800

tactaccacg ctcatggacg tgccgatgat acgatgaaca ttgggggaat taaaatttca     1860

tccatagaaa tagaacgtgt gtgtaacgaa gtcgatgatc gtgtattcga gactacagcg     1920

atcggtgtcc caccgttggg tgggggacca gaacaattgg taatcttttt tgttctgaaa     1980

gactccaacg atacgaccat cgacctaaat cagctgaggc tatcctttaa tctgggcttg     2040

cagaaaaagc taaatccttt attcaaagtc actagagttg ttcctttatc ttcattacca     2100

agaactgcaa caaataaaat aatgcgtaga gttctaaggc agcagtttag tcatttcgaa     2160


<210>  90
<211>  720
<212>  PRT
<213>  Cannabis sativa

<400>  90

Met Gly Lys Asn Tyr Lys Ser Leu Asp Ser Val Val Ala Ser Asp Phe 
1               5                   10                  15      


Ile Ala Leu Gly Ile Thr Ser Glu Val Ala Glu Thr Leu His Gly Arg 
            20                  25                  30          


Leu Ala Glu Ile Val Cys Asn Tyr Gly Ala Ala Thr Pro Gln Thr Trp 
        35                  40                  45              


Ile Asn Ile Ala Asn His Ile Leu Ser Pro Asp Leu Pro Phe Ser Leu 
    50                  55                  60                  


His Gln Met Leu Phe Tyr Gly Cys Tyr Lys Asp Phe Gly Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Trp Ile Pro Asp Pro Glu Lys Val Lys Ser Thr Asn Leu Gly 
                85                  90                  95      


Ala Leu Leu Glu Lys Arg Gly Lys Glu Phe Leu Gly Val Lys Tyr Lys 
            100                 105                 110         


Asp Pro Ile Ser Ser Phe Ser His Phe Gln Glu Phe Ser Val Arg Asn 
        115                 120                 125             


Pro Glu Val Tyr Trp Arg Thr Val Leu Met Asp Glu Met Lys Ile Ser 
    130                 135                 140                 


Phe Ser Lys Asp Pro Glu Cys Ile Leu Arg Arg Asp Asp Ile Asn Asn 
145                 150                 155                 160 


Pro Gly Gly Ser Glu Trp Leu Pro Gly Gly Tyr Leu Asn Ser Ala Lys 
                165                 170                 175     


Asn Cys Leu Asn Val Asn Ser Asn Lys Lys Leu Asn Asp Thr Met Ile 
            180                 185                 190         


Val Trp Arg Asp Glu Gly Asn Asp Asp Leu Pro Leu Asn Lys Leu Thr 
        195                 200                 205             


Leu Asp Gln Leu Arg Lys Arg Val Trp Leu Val Gly Tyr Ala Leu Glu 
    210                 215                 220                 


Glu Met Gly Leu Glu Lys Gly Cys Ala Ile Ala Ile Asp Met Pro Met 
225                 230                 235                 240 


His Val Asp Ala Val Val Ile Tyr Leu Ala Ile Val Leu Ala Gly Tyr 
                245                 250                 255     


Val Val Val Ser Ile Ala Asp Ser Phe Ser Ala Pro Glu Ile Ser Thr 
            260                 265                 270         


Arg Leu Arg Leu Ser Lys Ala Lys Ala Ile Phe Thr Gln Asp His Ile 
        275                 280                 285             


Ile Arg Gly Lys Lys Arg Ile Pro Leu Tyr Ser Arg Val Val Glu Ala 
    290                 295                 300                 


Lys Ser Pro Met Ala Ile Val Ile Pro Cys Ser Gly Ser Asn Ile Gly 
305                 310                 315                 320 


Ala Glu Leu Arg Asp Gly Asp Ile Ser Trp Asp Tyr Phe Leu Glu Arg 
                325                 330                 335     


Ala Lys Glu Phe Lys Asn Cys Glu Phe Thr Ala Arg Glu Gln Pro Val 
            340                 345                 350         


Asp Ala Tyr Thr Asn Ile Leu Phe Ser Ser Gly Thr Thr Gly Glu Pro 
        355                 360                 365             


Lys Ala Ile Pro Trp Thr Gln Ala Thr Pro Leu Lys Ala Ala Ala Asp 
    370                 375                 380                 


Gly Trp Ser His Leu Asp Ile Arg Lys Gly Asp Val Ile Val Trp Pro 
385                 390                 395                 400 


Thr Asn Leu Gly Trp Met Met Gly Pro Trp Leu Val Tyr Ala Ser Leu 
                405                 410                 415     


Leu Asn Gly Ala Ser Ile Ala Leu Tyr Asn Gly Ser Pro Leu Val Ser 
            420                 425                 430         


Gly Phe Ala Lys Phe Val Gln Asp Ala Lys Val Thr Met Leu Gly Val 
        435                 440                 445             


Val Pro Ser Ile Val Arg Ser Trp Lys Ser Thr Asn Cys Val Ser Gly 
    450                 455                 460                 


Tyr Asp Trp Ser Thr Ile Arg Cys Phe Ser Ser Ser Gly Glu Ala Ser 
465                 470                 475                 480 


Asn Val Asp Glu Tyr Leu Trp Leu Met Gly Arg Ala Asn Tyr Lys Pro 
                485                 490                 495     


Val Ile Glu Met Cys Gly Gly Thr Glu Ile Gly Gly Ala Phe Ser Ala 
            500                 505                 510         


Gly Ser Phe Leu Gln Ala Gln Ser Leu Ser Ser Phe Ser Ser Gln Cys 
        515                 520                 525             


Met Gly Cys Thr Leu Tyr Ile Leu Asp Lys Asn Gly Tyr Pro Met Pro 
    530                 535                 540                 


Lys Asn Lys Pro Gly Ile Gly Glu Leu Ala Leu Gly Pro Val Met Phe 
545                 550                 555                 560 


Gly Ala Ser Lys Thr Leu Leu Asn Gly Asn His His Asp Val Tyr Phe 
                565                 570                 575     


Lys Gly Met Pro Thr Leu Asn Gly Glu Val Leu Arg Arg His Gly Asp 
            580                 585                 590         


Ile Phe Glu Leu Thr Ser Asn Gly Tyr Tyr His Ala His Gly Arg Ala 
        595                 600                 605             


Asp Asp Thr Met Asn Ile Gly Gly Ile Lys Ile Ser Ser Ile Glu Ile 
    610                 615                 620                 


Glu Arg Val Cys Asn Glu Val Asp Asp Arg Val Phe Glu Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Val Pro Pro Leu Gly Gly Gly Pro Glu Gln Leu Val Ile Phe 
                645                 650                 655     


Phe Val Leu Lys Asp Ser Asn Asp Thr Thr Ile Asp Leu Asn Gln Leu 
            660                 665                 670         


Arg Leu Ser Phe Asn Leu Gly Leu Gln Lys Lys Leu Asn Pro Leu Phe 
        675                 680                 685             


Lys Val Thr Arg Val Val Pro Leu Ser Ser Leu Pro Arg Thr Ala Thr 
    690                 695                 700                 


Asn Lys Ile Met Arg Arg Val Leu Arg Gln Gln Phe Ser His Phe Glu 
705                 710                 715                 720 


<210>  91
<211>  1599
<212>  DNA
<213>  Cannabis sativa

<400>  91
atggaaaagt ctggttatgg tagagatggt atctacaggt ctttaagacc accattgcat       60

ttgccaaaca acaacaactt gtccatggtc agtttcttgt tcagaaactc ttcttcctac      120

ccacaaaaac cagccttgat tgactctgaa actaatcaaa tcttgtcctt ctcccacttc      180

aaatccaccg ttattaaggt ttctcacggt ttcttgaact tgggtatcaa gaagaatgac      240

tggttgatct acgctccaaa ctctattcat ttcccagttt gctttttggg tattattgct      300

tctggtgcta ttgctactac ttccaaccca ttatacaccg tcagtgaatt gtctaagcaa      360

gtcaaggatt ctaacccaaa gttgattatc accgttccac aattattgga aaaggtcaag      420

ggtttcaact tgccaaccat tttgattggt ccagactcag aacaagaatc ctcttcagat      480

aaggttatga ccttcaacga tttggttaac ttgggtggtt cttctggttc tgaatttcca      540

atcgttgatg acttcaagca atctgatact gctgctttgt tgtactcttc tggtactact      600

ggtatgtcta aaggttggtt gactcacaag aactttatcg cctcttcttt gatggttacc      660

atggaacaag acttggttgg tgaaatggat aacgttttct tgtgcttctt gccaatgttc      720

catgttttcg gtttggccat tattacctac gctcaattgc aaagaggtaa cactgttatt      780

tccgccagat tcgatttgga aaagatgttg aaggacgtcg aaaagtatgt tactcatttg      840

tggtggcctc cagttatttt ggctttgtct aaaaactcca tggttaagtt caacttgtca      900

tccatcaagt acattggttc aggtgctgct ccattgggta aggatttgat ggaagaatgt      960

tctaaatggc catacggtat agttgctcaa ggttacggta tgactgaaac ttgtggtatc     1020

gtttctatgg aagatatcag aggtggtaag agaaattctg gttcagctgg tatgttggct     1080

tcaggtgttg aagctcaaat agtttctgtt gataccttga aaccattgcc accaaatcaa     1140

ttgggtgaaa tttgggttaa gggtccaaat atgatgcaag gttacttcaa caatccacaa     1200

gctaccaagt tgaccattga taagaaaggt tgggttcata ctggtgactt gggttacttt     1260

gatgaagatg gtcacttgta ctgggacaga atcaaagaat tgattaagta caagggtttt     1320

caagtcgctc cagctgaatt ggaaggtttg ttggtttctc atccagaaat attggatgcc     1380

tggattccat ttccagatgc tgaagctggt gaagttccag ttgcttattg gagatcacca     1440

aactcttcat tgactgaaaa cgacgtcaag aagttcattg ctggtcaagt tgcttctttc     1500

aagagattga gaaaggtcac cttcatcaac tctgttccaa aatctgcttc cggtaagatc     1560

ttgagaagag aattgatcca aaaggtcaga tccaatatg                            1599


<210>  92
<211>  533
<212>  PRT
<213>  Cannabis sativa

<400>  92

Met Glu Lys Ser Gly Tyr Gly Arg Asp Gly Ile Tyr Arg Ser Leu Arg 
1               5                   10                  15      


Pro Pro Leu His Leu Pro Asn Asn Asn Asn Leu Ser Met Val Ser Phe 
            20                  25                  30          


Leu Phe Arg Asn Ser Ser Ser Tyr Pro Gln Lys Pro Ala Leu Ile Asp 
        35                  40                  45              


Ser Glu Thr Asn Gln Ile Leu Ser Phe Ser His Phe Lys Ser Thr Val 
    50                  55                  60                  


Ile Lys Val Ser His Gly Phe Leu Asn Leu Gly Ile Lys Lys Asn Asp 
65                  70                  75                  80  


Trp Leu Ile Tyr Ala Pro Asn Ser Ile His Phe Pro Val Cys Phe Leu 
                85                  90                  95      


Gly Ile Ile Ala Ser Gly Ala Ile Ala Thr Thr Ser Asn Pro Leu Tyr 
            100                 105                 110         


Thr Val Ser Glu Leu Ser Lys Gln Val Lys Asp Ser Asn Pro Lys Leu 
        115                 120                 125             


Ile Ile Thr Val Pro Gln Leu Leu Glu Lys Val Lys Gly Phe Asn Leu 
    130                 135                 140                 


Pro Thr Ile Leu Ile Gly Pro Asp Ser Glu Gln Glu Ser Ser Ser Asp 
145                 150                 155                 160 


Lys Val Met Thr Phe Asn Asp Leu Val Asn Leu Gly Gly Ser Ser Gly 
                165                 170                 175     


Ser Glu Phe Pro Ile Val Asp Asp Phe Lys Gln Ser Asp Thr Ala Ala 
            180                 185                 190         


Leu Leu Tyr Ser Ser Gly Thr Thr Gly Met Ser Lys Gly Trp Leu Thr 
        195                 200                 205             


His Lys Asn Phe Ile Ala Ser Ser Leu Met Val Thr Met Glu Gln Asp 
    210                 215                 220                 


Leu Val Gly Glu Met Asp Asn Val Phe Leu Cys Phe Leu Pro Met Phe 
225                 230                 235                 240 


His Val Phe Gly Leu Ala Ile Ile Thr Tyr Ala Gln Leu Gln Arg Gly 
                245                 250                 255     


Asn Thr Val Ile Ser Ala Arg Phe Asp Leu Glu Lys Met Leu Lys Asp 
            260                 265                 270         


Val Glu Lys Tyr Val Thr His Leu Trp Trp Pro Pro Val Ile Leu Ala 
        275                 280                 285             


Leu Ser Lys Asn Ser Met Val Lys Phe Asn Leu Ser Ser Ile Lys Tyr 
    290                 295                 300                 


Ile Gly Ser Gly Ala Ala Pro Leu Gly Lys Asp Leu Met Glu Glu Cys 
305                 310                 315                 320 


Ser Lys Trp Pro Tyr Gly Ile Val Ala Gln Gly Tyr Gly Met Thr Glu 
                325                 330                 335     


Thr Cys Gly Ile Val Ser Met Glu Asp Ile Arg Gly Gly Lys Arg Asn 
            340                 345                 350         


Ser Gly Ser Ala Gly Met Leu Ala Ser Gly Val Glu Ala Gln Ile Val 
        355                 360                 365             


Ser Val Asp Thr Leu Lys Pro Leu Pro Pro Asn Gln Leu Gly Glu Ile 
    370                 375                 380                 


Trp Val Lys Gly Pro Asn Met Met Gln Gly Tyr Phe Asn Asn Pro Gln 
385                 390                 395                 400 


Ala Thr Lys Leu Thr Ile Asp Lys Lys Gly Trp Val His Thr Gly Asp 
                405                 410                 415     


Leu Gly Tyr Phe Asp Glu Asp Gly His Leu Tyr Trp Asp Arg Ile Lys 
            420                 425                 430         


Glu Leu Ile Lys Tyr Lys Gly Phe Gln Val Ala Pro Ala Glu Leu Glu 
        435                 440                 445             


Gly Leu Leu Val Ser His Pro Glu Ile Leu Asp Ala Trp Ile Pro Phe 
    450                 455                 460                 


Pro Asp Ala Glu Ala Gly Glu Val Pro Val Ala Tyr Trp Arg Ser Pro 
465                 470                 475                 480 


Asn Ser Ser Leu Thr Glu Asn Asp Val Lys Lys Phe Ile Ala Gly Gln 
                485                 490                 495     


Val Ala Ser Phe Lys Arg Leu Arg Lys Val Thr Phe Ile Asn Ser Val 
            500                 505                 510         


Pro Lys Ser Ala Ser Gly Lys Ile Leu Arg Arg Glu Leu Ile Gln Lys 
        515                 520                 525             


Val Arg Ser Asn Met 
    530             


<210>  93
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial acetoacetyl-CoA reductase (PhaB) nucleotide sequence

<400>  93
atgacgcaga gaatcgccta tgtaacgggt gggatgggtg ggataggaac cgccatatgt       60

cagagactag caaaggacgg attcagggtt gtagccggtt gcggtcctaa tagtccaaga      120

agagagaaat ggttggaaca gcaaaaagct ctaggatttg attttatagc atcagaaggg      180

aatgttgctg actgggattc tacaaagacg gcatttgaca aagtgaaatc tgaagtcggc      240

gaggtcgatg tcctaattaa caacgccggc atcaccagag atgtggtttt caggaagatg      300

actagggctg actgggacgc cgtgatagac acaaatttga cgagcttgtt caacgtcaca      360

aagcaagtaa ttgacggcat ggcagatcgt gggtggggaa ggatagtcaa tatctccagc      420

gtcaacggtc agaaaggcca gttcggacag actaactact ccacagcgaa ggctggctta      480

cacggattca cgatggcctt ggcccaagag gtggctacta aaggggtgac tgtgaacaca      540

gtgtcaccag gatacatcgc gacggatatg gtcaaagcta ttagacaaga tgtcctggac      600

aagattgttg ccactattcc cgtaaagagg cttgggttac cagaagagat agcttcaatt      660

tgcgcttggc tatctagtga ggaatcaggg ttcagcactg gggcggactt ttcattaaac      720

ggtggattac acatgggagg atcc                                             744


<210>  94
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant acetoacetyl-CoA reductase (PhaB)

<400>  94

Met Thr Gln Arg Ile Ala Tyr Val Thr Gly Gly Met Gly Gly Ile Gly 
1               5                   10                  15      


Thr Ala Ile Cys Gln Arg Leu Ala Lys Asp Gly Phe Arg Val Val Ala 
            20                  25                  30          


Gly Cys Gly Pro Asn Ser Pro Arg Arg Glu Lys Trp Leu Glu Gln Gln 
        35                  40                  45              


Lys Ala Leu Gly Phe Asp Phe Ile Ala Ser Glu Gly Asn Val Ala Asp 
    50                  55                  60                  


Trp Asp Ser Thr Lys Thr Ala Phe Asp Lys Val Lys Ser Glu Val Gly 
65                  70                  75                  80  


Glu Val Asp Val Leu Ile Asn Asn Ala Gly Ile Thr Arg Asp Val Val 
                85                  90                  95      


Phe Arg Lys Met Thr Arg Ala Asp Trp Asp Ala Val Ile Asp Thr Asn 
            100                 105                 110         


Leu Thr Ser Leu Phe Asn Val Thr Lys Gln Val Ile Asp Gly Met Ala 
        115                 120                 125             


Asp Arg Gly Trp Gly Arg Ile Val Asn Ile Ser Ser Val Asn Gly Gln 
    130                 135                 140                 


Lys Gly Gln Phe Gly Gln Thr Asn Tyr Ser Thr Ala Lys Ala Gly Leu 
145                 150                 155                 160 


His Gly Phe Thr Met Ala Leu Ala Gln Glu Val Ala Thr Lys Gly Val 
                165                 170                 175     


Thr Val Asn Thr Val Ser Pro Gly Tyr Ile Ala Thr Asp Met Val Lys 
            180                 185                 190         


Ala Ile Arg Gln Asp Val Leu Asp Lys Ile Val Ala Thr Ile Pro Val 
        195                 200                 205             


Lys Arg Leu Gly Leu Pro Glu Glu Ile Ala Ser Ile Cys Ala Trp Leu 
    210                 215                 220                 


Ser Ser Glu Glu Ser Gly Phe Ser Thr Gly Ala Asp Phe Ser Leu Asn 
225                 230                 235                 240 


Gly Gly Leu His Met Gly Gly Ser 
                245             


<210>  95
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial (R)-specific enoyl-CoA hydratase (PhaJ)

<400>  95
atgtctgccc agagtctgga agtcggtcaa aaagcaagac tgtcaaaaag atttggggcg       60

gcagaggtag cggcgttcgc ggcgctgtct gaggatttta atccactgca cttagatcct      120

gcgttcgccg cgacaacagc attcgagagg cccatcgtgc acggcatgct acttgcctct      180

ttgttctcag gtctactggg tcaacagtta cctgggaaag gaagcatcta tctgggacag      240

tcattgtctt ttaagctgcc cgtcttcgtc ggcgatgagg tgacagcaga agtagaagtc      300

acagcattga gggaagacaa gcctattgcg acccttacta ctcgtatttt tactcagggc      360

ggagccttag cagtgacagg agaagctgta gtaaaactac caggatcc                   408


<210>  96
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant (R)-specific enoyl-CoA hydratase (PhaJ)

<400>  96

Met Ser Ala Gln Ser Leu Glu Val Gly Gln Lys Ala Arg Leu Ser Lys 
1               5                   10                  15      


Arg Phe Gly Ala Ala Glu Val Ala Ala Phe Ala Ala Leu Ser Glu Asp 
            20                  25                  30          


Phe Asn Pro Leu His Leu Asp Pro Ala Phe Ala Ala Thr Thr Ala Phe 
        35                  40                  45              


Glu Arg Pro Ile Val His Gly Met Leu Leu Ala Ser Leu Phe Ser Gly 
    50                  55                  60                  


Leu Leu Gly Gln Gln Leu Pro Gly Lys Gly Ser Ile Tyr Leu Gly Gln 
65                  70                  75                  80  


Ser Leu Ser Phe Lys Leu Pro Val Phe Val Gly Asp Glu Val Thr Ala 
                85                  90                  95      


Glu Val Glu Val Thr Ala Leu Arg Glu Asp Lys Pro Ile Ala Thr Leu 
            100                 105                 110         


Thr Thr Arg Ile Phe Thr Gln Gly Gly Ala Leu Ala Val Thr Gly Glu 
        115                 120                 125             


Ala Val Val Lys Leu Pro Gly Ser 
    130                 135     


<210>  97
<211>  2233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated acetyl-CoA carboxylase (ACC1) (S659A, S1157A)

<400>  97

Met Ser Glu Glu Ser Leu Phe Glu Ser Ser Pro Gln Lys Met Glu Tyr 
1               5                   10                  15      


Glu Ile Thr Asn Tyr Ser Glu Arg His Thr Glu Leu Pro Gly His Phe 
            20                  25                  30          


Ile Gly Leu Asn Thr Val Asp Lys Leu Glu Glu Ser Pro Leu Arg Asp 
        35                  40                  45              


Phe Val Lys Ser His Gly Gly His Thr Val Ile Ser Lys Ile Leu Ile 
    50                  55                  60                  


Ala Asn Asn Gly Ile Ala Ala Val Lys Glu Ile Arg Ser Val Arg Lys 
65                  70                  75                  80  


Trp Ala Tyr Glu Thr Phe Gly Asp Asp Arg Thr Val Gln Phe Val Ala 
                85                  90                  95      


Met Ala Thr Pro Glu Asp Leu Glu Ala Asn Ala Glu Tyr Ile Arg Met 
            100                 105                 110         


Ala Asp Gln Tyr Ile Glu Val Pro Gly Gly Thr Asn Asn Asn Asn Tyr 
        115                 120                 125             


Ala Asn Val Asp Leu Ile Val Asp Ile Ala Glu Arg Ala Asp Val Asp 
    130                 135                 140                 


Ala Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Lys Leu Ser Gln Ser Lys Arg Lys Val Ile Phe Ile Gly Pro Pro 
                165                 170                 175     


Gly Asn Ala Met Arg Ser Leu Gly Asp Lys Ile Ser Ser Thr Ile Val 
            180                 185                 190         


Ala Gln Ser Ala Lys Val Pro Cys Ile Pro Trp Ser Gly Thr Gly Val 
        195                 200                 205             


Asp Thr Val His Val Asp Glu Lys Thr Gly Leu Val Ser Val Asp Asp 
    210                 215                 220                 


Asp Ile Tyr Gln Lys Gly Cys Cys Thr Ser Pro Glu Asp Gly Leu Gln 
225                 230                 235                 240 


Lys Ala Lys Arg Ile Gly Phe Pro Val Met Ile Lys Ala Ser Glu Gly 
                245                 250                 255     


Gly Gly Gly Lys Gly Ile Arg Gln Val Glu Arg Glu Glu Asp Phe Ile 
            260                 265                 270         


Ala Leu Tyr His Gln Ala Ala Asn Glu Ile Pro Gly Ser Pro Ile Phe 
        275                 280                 285             


Ile Met Lys Leu Ala Gly Arg Ala Arg His Leu Glu Val Gln Leu Leu 
    290                 295                 300                 


Ala Asp Gln Tyr Gly Thr Asn Ile Ser Leu Phe Gly Arg Asp Cys Ser 
305                 310                 315                 320 


Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Val Thr Ile 
                325                 330                 335     


Ala Lys Ala Glu Thr Phe His Glu Met Glu Lys Ala Ala Val Arg Leu 
            340                 345                 350         


Gly Lys Leu Val Gly Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr 
        355                 360                 365             


Ser His Asp Asp Gly Lys Phe Tyr Phe Leu Glu Leu Asn Pro Arg Leu 
    370                 375                 380                 


Gln Val Glu His Pro Thr Thr Glu Met Val Ser Gly Val Asn Leu Pro 
385                 390                 395                 400 


Ala Ala Gln Leu Gln Ile Ala Met Gly Ile Pro Met His Arg Ile Ser 
                405                 410                 415     


Asp Ile Arg Thr Leu Tyr Gly Met Asn Pro His Ser Ala Ser Glu Ile 
            420                 425                 430         


Asp Phe Glu Phe Lys Thr Gln Asp Ala Thr Lys Lys Gln Arg Arg Pro 
        435                 440                 445             


Ile Pro Lys Gly His Cys Thr Ala Cys Arg Ile Thr Ser Glu Asp Pro 
    450                 455                 460                 


Asn Asp Gly Phe Lys Pro Ser Gly Gly Thr Leu His Glu Leu Asn Phe 
465                 470                 475                 480 


Arg Ser Ser Ser Asn Val Trp Gly Tyr Phe Ser Val Gly Asn Asn Gly 
                485                 490                 495     


Asn Ile His Ser Phe Ser Asp Ser Gln Phe Gly His Ile Phe Ala Phe 
            500                 505                 510         


Gly Glu Asn Arg Gln Ala Ser Arg Lys His Met Val Val Ala Leu Lys 
        515                 520                 525             


Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr Leu Ile 
    530                 535                 540                 


Lys Leu Leu Glu Thr Glu Asp Phe Glu Asp Asn Thr Ile Thr Thr Gly 
545                 550                 555                 560 


Trp Leu Asp Asp Leu Ile Thr His Lys Met Thr Ala Glu Lys Pro Asp 
                565                 570                 575     


Pro Thr Leu Ala Val Ile Cys Gly Ala Ala Thr Lys Ala Phe Leu Ala 
            580                 585                 590         


Ser Glu Glu Ala Arg His Lys Tyr Ile Glu Ser Leu Gln Lys Gly Gln 
        595                 600                 605             


Val Leu Ser Lys Asp Leu Leu Gln Thr Met Phe Pro Val Asp Phe Ile 
    610                 615                 620                 


His Glu Gly Lys Arg Tyr Lys Phe Thr Val Ala Lys Ser Gly Asn Asp 
625                 630                 635                 640 


Arg Tyr Thr Leu Phe Ile Asn Gly Ser Lys Cys Asp Ile Ile Leu Arg 
                645                 650                 655     


Gln Leu Ala Asp Gly Gly Leu Leu Ile Ala Ile Gly Gly Lys Ser His 
            660                 665                 670         


Thr Ile Tyr Trp Lys Glu Glu Val Ala Ala Thr Arg Leu Ser Val Asp 
        675                 680                 685             


Ser Met Thr Thr Leu Leu Glu Val Glu Asn Asp Pro Thr Gln Leu Arg 
    690                 695                 700                 


Thr Pro Ser Pro Gly Lys Leu Val Lys Phe Leu Val Glu Asn Gly Glu 
705                 710                 715                 720 


His Ile Ile Lys Gly Gln Pro Tyr Ala Glu Ile Glu Val Met Lys Met 
                725                 730                 735     


Gln Met Pro Leu Val Ser Gln Glu Asn Gly Ile Val Gln Leu Leu Lys 
            740                 745                 750         


Gln Pro Gly Ser Thr Ile Val Ala Gly Asp Ile Met Ala Ile Met Thr 
        755                 760                 765             


Leu Asp Asp Pro Ser Lys Val Lys His Ala Leu Pro Phe Glu Gly Met 
    770                 775                 780                 


Leu Pro Asp Phe Gly Ser Pro Val Ile Glu Gly Thr Lys Pro Ala Tyr 
785                 790                 795                 800 


Lys Phe Lys Ser Leu Val Ser Thr Leu Glu Asn Ile Leu Lys Gly Tyr 
                805                 810                 815     


Asp Asn Gln Val Ile Met Asn Ala Ser Leu Gln Gln Leu Ile Glu Val 
            820                 825                 830         


Leu Arg Asn Pro Lys Leu Pro Tyr Ser Glu Trp Lys Leu His Ile Ser 
        835                 840                 845             


Ala Leu His Ser Arg Leu Pro Ala Lys Leu Asp Glu Gln Met Glu Glu 
    850                 855                 860                 


Leu Val Ala Arg Ser Leu Arg Arg Gly Ala Val Phe Pro Ala Arg Gln 
865                 870                 875                 880 


Leu Ser Lys Leu Ile Asp Met Ala Val Lys Asn Pro Glu Tyr Asn Pro 
                885                 890                 895     


Asp Lys Leu Leu Gly Ala Val Val Glu Pro Leu Ala Asp Ile Ala His 
            900                 905                 910         


Lys Tyr Ser Asn Gly Leu Glu Ala His Glu His Ser Ile Phe Val His 
        915                 920                 925             


Phe Leu Glu Glu Tyr Tyr Glu Val Glu Lys Leu Phe Asn Gly Pro Asn 
    930                 935                 940                 


Val Arg Glu Glu Asn Ile Ile Leu Lys Leu Arg Asp Glu Asn Pro Lys 
945                 950                 955                 960 


Asp Leu Asp Lys Val Ala Leu Thr Val Leu Ser His Ser Lys Val Ser 
                965                 970                 975     


Ala Lys Asn Asn Leu Ile Leu Ala Ile Leu Lys His Tyr Gln Pro Leu 
            980                 985                 990         


Cys Lys Leu Ser Ser Lys Val Ser  Ala Ile Phe Ser Thr  Pro Leu Gln 
        995                 1000                 1005             


His Ile  Val Glu Leu Glu Ser  Lys Ala Thr Ala Lys  Val Ala Leu 
    1010                 1015                 1020             


Gln Ala  Arg Glu Ile Leu Ile  Gln Gly Ala Leu Pro  Ser Val Lys 
    1025                 1030                 1035             


Glu Arg  Thr Glu Gln Ile Glu  His Ile Leu Lys Ser  Ser Val Val 
    1040                 1045                 1050             


Lys Val  Ala Tyr Gly Ser Ser  Asn Pro Lys Arg Ser  Glu Pro Asp 
    1055                 1060                 1065             


Leu Asn  Ile Leu Lys Asp Leu  Ile Asp Ser Asn Tyr  Val Val Phe 
    1070                 1075                 1080             


Asp Val  Leu Leu Gln Phe Leu  Thr His Gln Asp Pro  Val Val Thr 
    1085                 1090                 1095             


Ala Ala  Ala Ala Gln Val Tyr  Ile Arg Arg Ala Tyr  Arg Ala Tyr 
    1100                 1105                 1110             


Thr Ile  Gly Asp Ile Arg Val  His Glu Gly Val Thr  Val Pro Ile 
    1115                 1120                 1125             


Val Glu  Trp Lys Phe Gln Leu  Pro Ser Ala Ala Phe  Ser Thr Phe 
    1130                 1135                 1140             


Pro Thr  Val Lys Ser Lys Met  Gly Met Asn Arg Ala  Val Ser Val 
    1145                 1150                 1155             


Ala Asp  Leu Ser Tyr Val Ala  Asn Ser Gln Ser Ser  Pro Leu Arg 
    1160                 1165                 1170             


Glu Gly  Ile Leu Met Ala Val  Asp His Leu Asp Asp  Val Asp Glu 
    1175                 1180                 1185             


Ile Leu  Ser Gln Ser Leu Glu  Val Ile Pro Arg His  Gln Ser Ser 
    1190                 1195                 1200             


Ser Asn  Gly Pro Ala Pro Asp  Arg Ser Gly Ser Ser  Ala Ser Leu 
    1205                 1210                 1215             


Ser Asn  Val Ala Asn Val Cys  Val Ala Ser Thr Glu  Gly Phe Glu 
    1220                 1225                 1230             


Ser Glu  Glu Glu Ile Leu Val  Arg Leu Arg Glu Ile  Leu Asp Leu 
    1235                 1240                 1245             


Asn Lys  Gln Glu Leu Ile Asn  Ala Ser Ile Arg Arg  Ile Thr Phe 
    1250                 1255                 1260             


Met Phe  Gly Phe Lys Asp Gly  Ser Tyr Pro Lys Tyr  Tyr Thr Phe 
    1265                 1270                 1275             


Asn Gly  Pro Asn Tyr Asn Glu  Asn Glu Thr Ile Arg  His Ile Glu 
    1280                 1285                 1290             


Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Gly Arg Leu  Ser Asn Phe 
    1295                 1300                 1305             


Asn Ile  Lys Pro Ile Phe Thr  Asp Asn Arg Asn Ile  His Val Tyr 
    1310                 1315                 1320             


Glu Ala  Val Ser Lys Thr Ser  Pro Leu Asp Lys Arg  Phe Phe Thr 
    1325                 1330                 1335             


Arg Gly  Ile Ile Arg Thr Gly  His Ile Arg Asp Asp  Ile Ser Ile 
    1340                 1345                 1350             


Gln Glu  Tyr Leu Thr Ser Glu  Ala Asn Arg Leu Met  Ser Asp Ile 
    1355                 1360                 1365             


Leu Asp  Asn Leu Glu Val Thr  Asp Thr Ser Asn Ser  Asp Leu Asn 
    1370                 1375                 1380             


His Ile  Phe Ile Asn Phe Ile  Ala Val Phe Asp Ile  Ser Pro Glu 
    1385                 1390                 1395             


Asp Val  Glu Ala Ala Phe Gly  Gly Phe Leu Glu Arg  Phe Gly Lys 
    1400                 1405                 1410             


Arg Leu  Leu Arg Leu Arg Val  Ser Ser Ala Glu Ile  Arg Ile Ile 
    1415                 1420                 1425             


Ile Lys  Asp Pro Gln Thr Gly  Ala Pro Val Pro Leu  Arg Ala Leu 
    1430                 1435                 1440             


Ile Asn  Asn Val Ser Gly Tyr  Val Ile Lys Thr Glu  Met Tyr Thr 
    1445                 1450                 1455             


Glu Val  Lys Asn Ala Lys Gly  Glu Trp Val Phe Lys  Ser Leu Gly 
    1460                 1465                 1470             


Lys Pro  Gly Ser Met His Leu  Arg Pro Ile Ala Thr  Pro Tyr Pro 
    1475                 1480                 1485             


Val Lys  Glu Trp Leu Gln Pro  Lys Arg Tyr Lys Ala  His Leu Met 
    1490                 1495                 1500             


Gly Thr  Thr Tyr Val Tyr Asp  Phe Pro Glu Leu Phe  Arg Gln Ala 
    1505                 1510                 1515             


Ser Ser  Ser Gln Trp Lys Asn  Phe Ser Ala Asp Val  Lys Leu Thr 
    1520                 1525                 1530             


Asp Asp  Phe Phe Ile Ser Asn  Glu Leu Ile Glu Asp  Glu Asn Gly 
    1535                 1540                 1545             


Glu Leu  Thr Glu Val Glu Arg  Glu Pro Gly Ala Asn  Ala Ile Gly 
    1550                 1555                 1560             


Met Val  Ala Phe Lys Ile Thr  Val Lys Thr Pro Glu  Tyr Pro Arg 
    1565                 1570                 1575             


Gly Arg  Gln Phe Val Val Val  Ala Asn Asp Ile Thr  Phe Lys Ile 
    1580                 1585                 1590             


Gly Ser  Phe Gly Pro Gln Glu  Asp Glu Phe Phe Asn  Lys Val Thr 
    1595                 1600                 1605             


Glu Tyr  Ala Arg Lys Arg Gly  Ile Pro Arg Ile Tyr  Leu Ala Ala 
    1610                 1615                 1620             


Asn Ser  Gly Ala Arg Ile Gly  Met Ala Glu Glu Ile  Val Pro Leu 
    1625                 1630                 1635             


Phe Gln  Val Ala Trp Asn Asp  Ala Ala Asn Pro Asp  Lys Gly Phe 
    1640                 1645                 1650             


Gln Tyr  Leu Tyr Leu Thr Ser  Glu Gly Met Glu Thr  Leu Lys Lys 
    1655                 1660                 1665             


Phe Asp  Lys Glu Asn Ser Val  Leu Thr Glu Arg Thr  Val Ile Asn 
    1670                 1675                 1680             


Gly Glu  Glu Arg Phe Val Ile  Lys Thr Ile Ile Gly  Ser Glu Asp 
    1685                 1690                 1695             


Gly Leu  Gly Val Glu Cys Leu  Arg Gly Ser Gly Leu  Ile Ala Gly 
    1700                 1705                 1710             


Ala Thr  Ser Arg Ala Tyr His  Asp Ile Phe Thr Ile  Thr Leu Val 
    1715                 1720                 1725             


Thr Cys  Arg Ser Val Gly Ile  Gly Ala Tyr Leu Val  Arg Leu Gly 
    1730                 1735                 1740             


Gln Arg  Ala Ile Gln Val Glu  Gly Gln Pro Ile Ile  Leu Thr Gly 
    1745                 1750                 1755             


Ala Pro  Ala Ile Asn Lys Met  Leu Gly Arg Glu Val  Tyr Thr Ser 
    1760                 1765                 1770             


Asn Leu  Gln Leu Gly Gly Thr  Gln Ile Met Tyr Asn  Asn Gly Val 
    1775                 1780                 1785             


Ser His  Leu Thr Ala Val Asp  Asp Leu Ala Gly Val  Glu Lys Ile 
    1790                 1795                 1800             


Val Glu  Trp Met Ser Tyr Val  Pro Ala Lys Arg Asn  Met Pro Val 
    1805                 1810                 1815             


Pro Ile  Leu Glu Thr Lys Asp  Thr Trp Asp Arg Pro  Val Asp Phe 
    1820                 1825                 1830             


Thr Pro  Thr Asn Asp Glu Thr  Tyr Asp Val Arg Trp  Met Ile Glu 
    1835                 1840                 1845             


Gly Arg  Glu Thr Glu Ser Gly  Phe Glu Tyr Gly Leu  Phe Asp Lys 
    1850                 1855                 1860             


Gly Ser  Phe Phe Glu Thr Leu  Ser Gly Trp Ala Lys  Gly Val Val 
    1865                 1870                 1875             


Val Gly  Arg Ala Arg Leu Gly  Gly Ile Pro Leu Gly  Val Ile Gly 
    1880                 1885                 1890             


Val Glu  Thr Arg Thr Val Glu  Asn Leu Ile Pro Ala  Asp Pro Ala 
    1895                 1900                 1905             


Asn Pro  Asn Ser Ala Glu Thr  Leu Ile Gln Glu Pro  Gly Gln Val 
    1910                 1915                 1920             


Trp His  Pro Asn Ser Ala Phe  Lys Thr Ala Gln Ala  Ile Asn Asp 
    1925                 1930                 1935             


Phe Asn  Asn Gly Glu Gln Leu  Pro Met Met Ile Leu  Ala Asn Trp 
    1940                 1945                 1950             


Arg Gly  Phe Ser Gly Gly Gln  Arg Asp Met Phe Asn  Glu Val Leu 
    1955                 1960                 1965             


Lys Tyr  Gly Ser Phe Ile Val  Asp Ala Leu Val Asp  Tyr Lys Gln 
    1970                 1975                 1980             


Pro Ile  Ile Ile Tyr Ile Pro  Pro Thr Gly Glu Leu  Arg Gly Gly 
    1985                 1990                 1995             


Ser Trp  Val Val Val Asp Pro  Thr Ile Asn Ala Asp  Gln Met Glu 
    2000                 2005                 2010             


Met Tyr  Ala Asp Val Asn Ala  Arg Ala Gly Val Leu  Glu Pro Gln 
    2015                 2020                 2025             


Gly Met  Val Gly Ile Lys Phe  Arg Arg Glu Lys Leu  Leu Asp Thr 
    2030                 2035                 2040             


Met Asn  Arg Leu Asp Asp Lys  Tyr Arg Glu Leu Arg  Ser Gln Leu 
    2045                 2050                 2055             


Ser Asn  Lys Ser Leu Ala Pro  Glu Val His Gln Gln  Ile Ser Lys 
    2060                 2065                 2070             


Gln Leu  Ala Asp Arg Glu Arg  Glu Leu Leu Pro Ile  Tyr Gly Gln 
    2075                 2080                 2085             


Ile Ser  Leu Gln Phe Ala Asp  Leu His Asp Arg Ser  Ser Arg Met 
    2090                 2095                 2100             


Val Ala  Lys Gly Val Ile Ser  Lys Glu Leu Glu Trp  Thr Glu Ala 
    2105                 2110                 2115             


Arg Arg  Phe Phe Phe Trp Arg  Leu Arg Arg Arg Leu  Asn Glu Glu 
    2120                 2125                 2130             


Tyr Leu  Ile Lys Arg Leu Ser  His Gln Val Gly Glu  Ala Ser Arg 
    2135                 2140                 2145             


Leu Glu  Lys Ile Ala Arg Ile  Arg Ser Trp Tyr Pro  Ala Ser Val 
    2150                 2155                 2160             


Asp His  Glu Asp Asp Arg Gln  Val Ala Thr Trp Ile  Glu Glu Asn 
    2165                 2170                 2175             


Tyr Lys  Thr Leu Asp Asp Lys  Leu Lys Gly Leu Lys  Leu Glu Ser 
    2180                 2185                 2190             


Phe Ala  Gln Asp Leu Ala Lys  Lys Ile Arg Ser Asp  His Asp Asn 
    2195                 2200                 2205             


Ala Ile  Asp Gly Leu Ser Glu  Val Ile Lys Met Leu  Ser Thr Asp 
    2210                 2215                 2220             


Asp Lys  Glu Lys Leu Leu Lys  Thr Leu Lys 
    2225                 2230             


<210>  98
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsGOTt75

<400>  98

Met Ala Ala Thr Thr Asn Gln Thr Glu Pro Pro Glu Ser Asp Asn His 
1               5                   10                  15      


Ser Val Ala Thr Lys Ile Leu Asn Phe Gly Lys Ala Cys Trp Lys Leu 
            20                  25                  30          


Gln Arg Pro Tyr Thr Ile Ile Ala Phe Thr Ser Cys Ala Cys Gly Leu 
        35                  40                  45              


Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Ser Leu 
    50                  55                  60                  


Met Phe Lys Ala Phe Phe Phe Leu Val Ala Ile Leu Cys Ile Ala Ser 
65                  70                  75                  80  


Phe Thr Thr Thr Ile Asn Gln Ile Tyr Asp Leu His Ile Asp Arg Ile 
                85                  90                  95      


Asn Lys Pro Asp Leu Pro Leu Ala Ser Gly Glu Ile Ser Val Asn Thr 
            100                 105                 110         


Ala Trp Ile Met Ser Ile Ile Val Ala Leu Phe Gly Leu Ile Ile Thr 
        115                 120                 125             


Ile Lys Met Lys Gly Gly Pro Leu Tyr Ile Phe Gly Tyr Cys Phe Gly 
    130                 135                 140                 


Ile Phe Gly Gly Ile Val Tyr Ser Val Pro Pro Phe Arg Trp Lys Gln 
145                 150                 155                 160 


Asn Pro Ser Thr Ala Phe Leu Leu Asn Phe Leu Ala His Ile Ile Thr 
                165                 170                 175     


Asn Phe Thr Phe Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe 
            180                 185                 190         


Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Lys Ser Met 
        195                 200                 205             


Gly Ser Ala Leu Ala Leu Ile Lys Asp Ala Ser Asp Val Glu Gly Asp 
    210                 215                 220                 


Thr Lys Phe Gly Ile Ser Thr Leu Ala Ser Lys Tyr Gly Ser Arg Asn 
225                 230                 235                 240 


Leu Thr Leu Phe Cys Ser Gly Ile Val Leu Leu Ser Tyr Val Ala Ala 
                245                 250                 255     


Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val Met 
            260                 265                 270         


Leu Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile Leu Gln Thr Arg 
        275                 280                 285             


Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly Arg Arg Phe Tyr 
    290                 295                 300                 


Glu Phe Met Trp Lys Leu Tyr Tyr Ala Glu Tyr Leu Val Tyr Val Phe 
305                 310                 315                 320 


Ile 
    


<210>  99
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsGOTt33

<400>  99

Met Ser His Pro Lys Thr Pro Ile Lys Tyr Ser Tyr Asn Asn Phe Pro 
1               5                   10                  15      


Ser Lys His Cys Ser Thr Lys Ser Phe His Leu Gln Asn Lys Cys Ser 
            20                  25                  30          


Glu Ser Leu Ser Ile Ala Lys Asn Ser Ile Arg Ala Ala Thr Thr Asn 
        35                  40                  45              


Gln Thr Glu Pro Pro Glu Ser Asp Asn His Ser Val Ala Thr Lys Ile 
    50                  55                  60                  


Leu Asn Phe Gly Lys Ala Cys Trp Lys Leu Gln Arg Pro Tyr Thr Ile 
65                  70                  75                  80  


Ile Ala Phe Thr Ser Cys Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu 
                85                  90                  95      


His Asn Thr Asn Leu Ile Ser Trp Ser Leu Met Phe Lys Ala Phe Phe 
            100                 105                 110         


Phe Leu Val Ala Ile Leu Cys Ile Ala Ser Phe Thr Thr Thr Ile Asn 
        115                 120                 125             


Gln Ile Tyr Asp Leu His Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
    130                 135                 140                 


Leu Ala Ser Gly Glu Ile Ser Val Asn Thr Ala Trp Ile Met Ser Ile 
145                 150                 155                 160 


Ile Val Ala Leu Phe Gly Leu Ile Ile Thr Ile Lys Met Lys Gly Gly 
                165                 170                 175     


Pro Leu Tyr Ile Phe Gly Tyr Cys Phe Gly Ile Phe Gly Gly Ile Val 
            180                 185                 190         


Tyr Ser Val Pro Pro Phe Arg Trp Lys Gln Asn Pro Ser Thr Ala Phe 
        195                 200                 205             


Leu Leu Asn Phe Leu Ala His Ile Ile Thr Asn Phe Thr Phe Tyr Tyr 
    210                 215                 220                 


Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe 
225                 230                 235                 240 


Thr Phe Leu Leu Ala Phe Met Lys Ser Met Gly Ser Ala Leu Ala Leu 
                245                 250                 255     


Ile Lys Asp Ala Ser Asp Val Glu Gly Asp Thr Lys Phe Gly Ile Ser 
            260                 265                 270         


Thr Leu Ala Ser Lys Tyr Gly Ser Arg Asn Leu Thr Leu Phe Cys Ser 
        275                 280                 285             


Gly Ile Val Leu Leu Ser Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile 
    290                 295                 300                 


Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser His Ala Ile 
305                 310                 315                 320 


Leu Ala Phe Trp Leu Ile Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn 
                325                 330                 335     


Tyr Asp Pro Glu Ala Gly Arg Arg Phe Tyr Glu Phe Met Trp Lys Leu 
            340                 345                 350         


Tyr Tyr Ala Glu Tyr Leu Val Tyr Val Phe Ile 
        355                 360             


<210>  100
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4t

<400>  100

Met Ser Ala Gly Ser Asp Gln Ile Glu Gly Ser Pro His His Glu Ser 
1               5                   10                  15      


Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp 
            20                  25                  30          


Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys 
        35                  40                  45              


Gly Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp 
    50                  55                  60                  


Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe 
65                  70                  75                  80  


Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp 
                85                  90                  95      


Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile 
            100                 105                 110         


Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile 
        115                 120                 125             


Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile 
    130                 135                 140                 


Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp 
145                 150                 155                 160 


Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val 
                165                 170                 175     


Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu 
            180                 185                 190         


Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr 
        195                 200                 205             


Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu 
    210                 215                 220                 


Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala 
225                 230                 235                 240 


Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu 
                245                 250                 255     


Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn 
            260                 265                 270         


Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln 
        275                 280                 285             


Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln 
    290                 295                 300                 


Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr 
305                 310                 315                 320 


Val Phe Ile 
            


<210>  101
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT7t

<400>  101

Met Ser Thr Asp Thr Ala Asn Gln Thr Glu Pro Pro Glu Ser Asn Thr 
1               5                   10                  15      


Lys Tyr Ser Val Val Thr Lys Ile Leu Ser Phe Gly His Thr Cys Trp 
            20                  25                  30          


Lys Leu Gln Arg Pro Tyr Thr Phe Ile Gly Val Ile Ser Cys Ala Cys 
        35                  40                  45              


Gly Leu Phe Gly Arg Glu Leu Phe His Asn Thr Asn Leu Leu Ser Trp 
    50                  55                  60                  


Ser Leu Met Leu Lys Ala Phe Ser Ser Leu Met Val Ile Leu Ser Val 
65                  70                  75                  80  


Asn Leu Cys Thr Asn Ile Ile Asn Gln Ile Thr Asp Leu Asp Ile Asp 
                85                  90                  95      


Arg Ile Asn Lys Pro Asp Leu Pro Leu Ala Ser Gly Glu Met Ser Ile 
            100                 105                 110         


Glu Thr Ala Trp Ile Met Ser Ile Ile Val Ala Leu Thr Gly Leu Ile 
        115                 120                 125             


Leu Thr Ile Lys Leu Asn Cys Gly Pro Leu Phe Ile Ser Leu Tyr Cys 
    130                 135                 140                 


Val Ser Ile Leu Val Gly Ala Leu Tyr Ser Val Pro Pro Phe Arg Trp 
145                 150                 155                 160 


Lys Gln Asn Pro Asn Thr Ala Phe Ser Ser Tyr Phe Met Gly Leu Val 
                165                 170                 175     


Ile Val Asn Phe Thr Cys Tyr Tyr Ala Ser Arg Ala Ala Phe Gly Leu 
            180                 185                 190         


Pro Phe Glu Met Ser Pro Pro Phe Thr Phe Ile Leu Ala Phe Val Lys 
        195                 200                 205             


Ser Met Gly Ser Ala Leu Phe Leu Cys Lys Asp Val Ser Asp Ile Glu 
    210                 215                 220                 


Gly Asp Ser Lys His Gly Ile Ser Thr Leu Ala Thr Arg Tyr Gly Ala 
225                 230                 235                 240 


Lys Asn Ile Thr Phe Leu Cys Ser Gly Ile Val Leu Leu Thr Tyr Val 
                245                 250                 255     


Ser Ala Ile Leu Ala Ala Ile Ile Trp Pro Gln Ala Phe Lys Ser Asn 
            260                 265                 270         


Val Met Leu Leu Ser His Ala Thr Leu Ala Phe Trp Leu Ile Phe Gln 
        275                 280                 285             


Thr Arg Glu Phe Ala Leu Thr Asn Tyr Asn Pro Glu Ala Gly Arg Lys 
    290                 295                 300                 


Phe Tyr Glu Phe Met Trp Lys Leu His Tyr Ala Glu Tyr Leu Val Tyr 
305                 310                 315                 320 


Val Phe Ile 
            


<210>  102
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase HlPT1Lt

<400>  102

Met Asp Arg Pro Pro Glu Ser Gly Asn Leu Ser Ala Leu Thr Asn Val 
1               5                   10                  15      


Lys Asp Phe Val Ser Val Cys Trp Glu Tyr Val Arg Pro Tyr Thr Ala 
            20                  25                  30          


Lys Gly Val Ile Ile Cys Ser Ser Cys Leu Phe Gly Arg Glu Leu Leu 
        35                  40                  45              


Glu Asn Pro Asn Leu Phe Ser Trp Pro Leu Ile Phe Arg Ala Leu Leu 
    50                  55                  60                  


Gly Met Leu Ala Ile Leu Gly Ser Cys Phe Tyr Thr Ala Gly Ile Asn 
65                  70                  75                  80  


Gln Ile Phe Asp Met Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
                85                  90                  95      


Leu Val Ser Gly Arg Ile Ser Val Glu Ser Ala Trp Leu Leu Thr Leu 
            100                 105                 110         


Ser Pro Ala Ile Ile Gly Phe Ile Leu Ile Leu Lys Leu Asn Ser Gly 
        115                 120                 125             


Pro Leu Leu Thr Ser Leu Tyr Cys Leu Ala Ile Leu Ser Gly Thr Ile 
    130                 135                 140                 


Tyr Ser Val Pro Pro Phe Arg Trp Lys Lys Asn Pro Ile Thr Ala Phe 
145                 150                 155                 160 


Leu Cys Ile Leu Met Ile His Ala Gly Leu Asn Phe Ser Val Tyr Tyr 
                165                 170                 175     


Ala Ser Arg Ala Ala Leu Gly Leu Ala Phe Val Trp Ser Pro Ser Phe 
            180                 185                 190         


Ser Phe Ile Thr Ala Phe Ile Thr Phe Met Thr Leu Thr Leu Ala Ser 
        195                 200                 205             


Ser Lys Asp Leu Ser Asp Ile Asn Gly Asp Arg Lys Phe Gly Val Glu 
    210                 215                 220                 


Thr Phe Ala Thr Lys Leu Gly Ala Lys Asn Ile Thr Leu Leu Gly Thr 
225                 230                 235                 240 


Gly Leu Leu Leu Leu Asn Tyr Val Ala Ala Ile Ser Thr Ala Ile Ile 
                245                 250                 255     


Trp Pro Lys Ala Phe Lys Ser Asn Ile Met Leu Leu Ser His Ala Ile 
            260                 265                 270         


Leu Ala Phe Ser Leu Phe Phe Gln Ala Arg Glu Leu Asp Arg Thr Asn 
        275                 280                 285             


Tyr Thr Pro Glu Ala Cys Lys Ser Phe Tyr Glu Phe Ile Trp Ile Leu 
    290                 295                 300                 


Phe Ser Ala Glu Tyr Val Val Tyr Leu Phe Ile 
305                 310                 315 


<210>  103
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase HlPT2t

<400>  103

Met Gly His Leu Pro Arg Pro Asn Ser Leu Thr Ala Trp Ser His Gln 
1               5                   10                  15      


Ser Glu Phe Pro Ser Thr Ile Val Thr Lys Gly Ser Asn Phe Gly His 
            20                  25                  30          


Ala Ser Trp Lys Phe Val Arg Pro Ile Pro Phe Val Ala Val Ser Ile 
        35                  40                  45              


Ile Cys Thr Ser Leu Phe Gly Ala Glu Leu Leu Lys Asn Pro Asn Leu 
    50                  55                  60                  


Phe Ser Trp Gln Leu Met Phe Asp Ala Phe Gln Gly Leu Val Val Ile 
65                  70                  75                  80  


Leu Leu Tyr His Ile Tyr Ile Asn Gly Leu Asn Gln Ile Tyr Asp Leu 
                85                  90                  95      


Glu Ser Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Ala Ala Glu Glu 
            100                 105                 110         


Met Ser Val Lys Ser Ala Trp Phe Leu Thr Ile Phe Ser Ala Val Ala 
        115                 120                 125             


Ser Leu Leu Leu Met Ile Lys Leu Lys Cys Gly Leu Phe Leu Thr Cys 
    130                 135                 140                 


Met Tyr Cys Cys Tyr Leu Val Ile Gly Ala Met Tyr Ser Val Pro Pro 
145                 150                 155                 160 


Phe Arg Trp Lys Met Asn Thr Phe Thr Ser Thr Leu Trp Asn Phe Ser 
                165                 170                 175     


Glu Ile Gly Ile Gly Ile Asn Phe Leu Ile Asn Tyr Ala Ser Arg Ala 
            180                 185                 190         


Thr Leu Gly Leu Pro Phe Gln Trp Arg Pro Pro Phe Thr Phe Ile Ile 
        195                 200                 205             


Gly Phe Val Ser Thr Leu Ser Ile Ile Leu Ser Ile Leu Lys Asp Val 
    210                 215                 220                 


Pro Asp Val Glu Gly Asp Lys Lys Val Gly Met Ser Thr Leu Pro Val 
225                 230                 235                 240 


Ile Phe Gly Ala Arg Thr Ile Val Leu Val Gly Ser Gly Phe Phe Leu 
                245                 250                 255     


Leu Asn Tyr Val Ala Ala Ile Gly Val Ala Ile Met Trp Pro Gln Ala 
            260                 265                 270         


Phe Lys Gly Tyr Ile Met Ile Pro Ala His Ala Ile Phe Ala Ser Ala 
        275                 280                 285             


Leu Ile Phe Lys Thr Trp Leu Leu Asp Lys Ala Asn Tyr Ala Lys Glu 
    290                 295                 300                 


Ala Ser Asp Ser Tyr Tyr His Phe Leu Trp Phe Leu Met Ile Ala Glu 
305                 310                 315                 320 


Tyr Ile Leu Tyr Pro Phe Ile Ser Thr 
                325                 


<210>  104
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated tetrahydrocannabinolic acid synthase THCASt28

<400>  104

Met Asn Phe Leu Lys Cys Phe Ser Glu Tyr Ile Pro Asn Asn Pro Ala 
1               5                   10                  15      


Asn Pro Lys Phe Ile Tyr Thr Gln His Asp Gln Leu Tyr Met Ser Val 
            20                  25                  30          


Leu Asn Ser Thr Ile Gln Asn Leu Arg Phe Thr Ser Asp Thr Thr Pro 
        35                  40                  45              


Lys Pro Leu Val Ile Val Thr Pro Ser Asn Val Ser His Ile Gln Ala 
    50                  55                  60                  


Ser Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser 
65                  70                  75                  80  


Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe 
                85                  90                  95      


Val Val Val Asp Leu Arg Asn Met His Ser Ile Lys Ile Asp Val His 
            100                 105                 110         


Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr 
        115                 120                 125             


Tyr Trp Ile Asn Glu Lys Asn Glu Asn Phe Ser Phe Pro Gly Gly Tyr 
    130                 135                 140                 


Cys Pro Thr Val Gly Val Gly Gly His Phe Ser Gly Gly Gly Tyr Gly 
145                 150                 155                 160 


Ala Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala 
                165                 170                 175     


His Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg Lys Ser Met Gly 
            180                 185                 190         


Glu Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly Glu Asn Phe Gly 
        195                 200                 205             


Ile Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val Pro Ser Lys Ser 
    210                 215                 220                 


Thr Ile Phe Ser Val Lys Lys Asn Met Glu Ile His Gly Leu Val Lys 
225                 230                 235                 240 


Leu Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu 
                245                 250                 255     


Val Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr Asp Asn His Gly 
            260                 265                 270         


Lys Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser Ile Phe His Gly 
        275                 280                 285             


Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu 
    290                 295                 300                 


Gly Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp Ile Asp Thr Thr 
305                 310                 315                 320 


Ile Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala Asn Phe Lys Lys 
                325                 330                 335     


Glu Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr Ala Phe Ser Ile 
            340                 345                 350         


Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr Ala Met Val Lys 
        355                 360                 365             


Ile Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Val Gly Met Tyr Val 
    370                 375                 380                 


Leu Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser Glu Ser Ala Ile 
385                 390                 395                 400 


Pro Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Thr Ala 
                405                 410                 415     


Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile Asn Trp Val Arg 
            420                 425                 430         


Ser Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln Asn Pro Arg Leu 
        435                 440                 445             


Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys Thr Asn Pro Glu 
    450                 455                 460                 


Ser Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe 
465                 470                 475                 480 


Gly Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr Lys Ala Asp Pro 
                485                 490                 495     


Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Pro His 
            500                 505                 510         


His His 
        


<210>  105
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated cannabidiolic acid synthase CBDASt28*

<400>  105

Met Asn Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro 
1               5                   10                  15      


Asn Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu 
            20                  25                  30          


Tyr Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser 
        35                  40                  45              


Asp Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser 
    50                  55                  60                  


His Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile 
65                  70                  75                  80  


Arg Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser 
                85                  90                  95      


Gln Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys 
            100                 105                 110         


Ile Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu 
        115                 120                 125             


Gly Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu 
    130                 135                 140                 


Ala Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly 
145                 150                 155                 160 


Gly Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn 
                165                 170                 175     


Ile Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg 
            180                 185                 190         


Lys Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala 
        195                 200                 205             


Glu Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val 
    210                 215                 220                 


Pro Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His 
        515         


<210>  106
<211>  2051
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated fatty acid synthase (FAS1, I306A, R1834K)

<400>  106

Met Asp Ala Tyr Ser Thr Arg Pro Leu Thr Leu Ser His Gly Ser Leu 
1               5                   10                  15      


Glu His Val Leu Leu Val Pro Thr Ala Ser Phe Phe Ile Ala Ser Gln 
            20                  25                  30          


Leu Gln Glu Gln Phe Asn Lys Ile Leu Pro Glu Pro Thr Glu Gly Phe 
        35                  40                  45              


Ala Ala Asp Asp Glu Pro Thr Thr Pro Ala Glu Leu Val Gly Lys Phe 
    50                  55                  60                  


Leu Gly Tyr Val Ser Ser Leu Val Glu Pro Ser Lys Val Gly Gln Phe 
65                  70                  75                  80  


Asp Gln Val Leu Asn Leu Cys Leu Thr Glu Phe Glu Asn Cys Tyr Leu 
                85                  90                  95      


Glu Gly Asn Asp Ile His Ala Leu Ala Ala Lys Leu Leu Gln Glu Asn 
            100                 105                 110         


Asp Thr Thr Leu Val Lys Thr Lys Glu Leu Ile Lys Asn Tyr Ile Thr 
        115                 120                 125             


Ala Arg Ile Met Ala Lys Arg Pro Phe Asp Lys Lys Ser Asn Ser Ala 
    130                 135                 140                 


Leu Phe Arg Ala Val Gly Glu Gly Asn Ala Gln Leu Val Ala Ile Phe 
145                 150                 155                 160 


Gly Gly Gln Gly Asn Thr Asp Asp Tyr Phe Glu Glu Leu Arg Asp Leu 
                165                 170                 175     


Tyr Gln Thr Tyr His Val Leu Val Gly Asp Leu Ile Lys Phe Ser Ala 
            180                 185                 190         


Glu Thr Leu Ser Glu Leu Ile Arg Thr Thr Leu Asp Ala Glu Lys Val 
        195                 200                 205             


Phe Thr Gln Gly Leu Asn Ile Leu Glu Trp Leu Glu Asn Pro Ser Asn 
    210                 215                 220                 


Thr Pro Asp Lys Asp Tyr Leu Leu Ser Ile Pro Ile Ser Cys Pro Leu 
225                 230                 235                 240 


Ile Gly Val Ile Gln Leu Ala His Tyr Val Val Thr Ala Lys Leu Leu 
                245                 250                 255     


Gly Phe Thr Pro Gly Glu Leu Arg Ser Tyr Leu Lys Gly Ala Thr Gly 
            260                 265                 270         


His Ser Gln Gly Leu Val Thr Ala Val Ala Ile Ala Glu Thr Asp Ser 
        275                 280                 285             


Trp Glu Ser Phe Phe Val Ser Val Arg Lys Ala Ile Thr Val Leu Phe 
    290                 295                 300                 


Phe Gly Gly Val Arg Cys Tyr Glu Ala Tyr Pro Asn Thr Ser Leu Pro 
305                 310                 315                 320 


Pro Ser Ile Leu Glu Asp Ser Leu Glu Asn Asn Glu Gly Val Pro Ser 
                325                 330                 335     


Pro Met Leu Ser Ile Ser Asn Leu Thr Gln Glu Gln Val Gln Asp Tyr 
            340                 345                 350         


Val Asn Lys Thr Asn Ser His Leu Pro Ala Gly Lys Gln Val Glu Ile 
        355                 360                 365             


Ser Leu Val Asn Gly Ala Lys Asn Leu Val Val Ser Gly Pro Pro Gln 
    370                 375                 380                 


Ser Leu Tyr Gly Leu Asn Leu Thr Leu Arg Lys Ala Lys Ala Pro Ser 
385                 390                 395                 400 


Gly Leu Asp Gln Ser Arg Ile Pro Phe Ser Glu Arg Lys Leu Lys Phe 
                405                 410                 415     


Ser Asn Arg Phe Leu Pro Val Ala Ser Pro Phe His Ser His Leu Leu 
            420                 425                 430         


Val Pro Ala Ser Asp Leu Ile Asn Lys Asp Leu Val Lys Asn Asn Val 
        435                 440                 445             


Ser Phe Asn Ala Lys Asp Ile Gln Ile Pro Val Tyr Asp Thr Phe Asp 
    450                 455                 460                 


Gly Ser Asp Leu Arg Val Leu Ser Gly Ser Ile Ser Glu Arg Ile Val 
465                 470                 475                 480 


Asp Cys Ile Ile Arg Leu Pro Val Lys Trp Glu Thr Thr Thr Gln Phe 
                485                 490                 495     


Lys Ala Thr His Ile Leu Asp Phe Gly Pro Gly Gly Ala Ser Gly Leu 
            500                 505                 510         


Gly Val Leu Thr His Arg Asn Lys Asp Gly Thr Gly Val Arg Val Ile 
        515                 520                 525             


Val Ala Gly Thr Leu Asp Ile Asn Pro Asp Asp Asp Tyr Gly Phe Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Val Thr Ser Asn Gly Leu Lys Lys Asn Pro Asn 
545                 550                 555                 560 


Trp Leu Glu Glu Tyr His Pro Lys Leu Ile Lys Asn Lys Ser Gly Lys 
                565                 570                 575     


Ile Phe Val Glu Thr Lys Phe Ser Lys Leu Ile Gly Arg Pro Pro Leu 
            580                 585                 590         


Leu Val Pro Gly Met Thr Pro Cys Thr Val Ser Pro Asp Phe Val Ala 
        595                 600                 605             


Ala Thr Thr Asn Ala Gly Tyr Thr Ile Glu Leu Ala Gly Gly Gly Tyr 
    610                 615                 620                 


Phe Ser Ala Ala Gly Met Thr Ala Ala Ile Asp Ser Val Val Ser Gln 
625                 630                 635                 640 


Ile Glu Lys Gly Ser Thr Phe Gly Ile Asn Leu Ile Tyr Val Asn Pro 
                645                 650                 655     


Phe Met Leu Gln Trp Gly Ile Pro Leu Ile Lys Glu Leu Arg Ser Lys 
            660                 665                 670         


Gly Tyr Pro Ile Gln Phe Leu Thr Ile Gly Ala Gly Val Pro Ser Leu 
        675                 680                 685             


Glu Val Ala Ser Glu Tyr Ile Glu Thr Leu Gly Leu Lys Tyr Leu Gly 
    690                 695                 700                 


Leu Lys Pro Gly Ser Ile Asp Ala Ile Ser Gln Val Ile Asn Ile Ala 
705                 710                 715                 720 


Lys Ala His Pro Asn Phe Pro Ile Ala Leu Gln Trp Thr Gly Gly Arg 
                725                 730                 735     


Gly Gly Gly His His Ser Phe Glu Asp Ala His Thr Pro Met Leu Gln 
            740                 745                 750         


Met Tyr Ser Lys Ile Arg Arg His Pro Asn Ile Met Leu Ile Phe Gly 
        755                 760                 765             


Ser Gly Phe Gly Ser Ala Asp Asp Thr Tyr Pro Tyr Leu Thr Gly Glu 
    770                 775                 780                 


Trp Ser Thr Lys Phe Asp Tyr Pro Pro Met Pro Phe Asp Gly Phe Leu 
785                 790                 795                 800 


Phe Gly Ser Arg Val Met Ile Ala Lys Glu Val Lys Thr Ser Pro Asp 
                805                 810                 815     


Ala Lys Lys Cys Ile Ala Ala Cys Thr Gly Val Pro Asp Asp Lys Trp 
            820                 825                 830         


Glu Gln Thr Tyr Lys Lys Pro Thr Gly Gly Ile Val Thr Val Arg Ser 
        835                 840                 845             


Glu Met Gly Glu Pro Ile His Lys Ile Ala Thr Arg Gly Val Met Leu 
    850                 855                 860                 


Trp Lys Glu Phe Asp Glu Thr Ile Phe Asn Leu Pro Lys Asn Lys Leu 
865                 870                 875                 880 


Val Pro Thr Leu Glu Ala Lys Arg Asp Tyr Ile Ile Ser Arg Leu Asn 
                885                 890                 895     


Ala Asp Phe Gln Lys Pro Trp Phe Ala Thr Val Asn Gly Gln Ala Arg 
            900                 905                 910         


Asp Leu Ala Thr Met Thr Tyr Glu Glu Val Ala Lys Arg Leu Val Glu 
        915                 920                 925             


Leu Met Phe Ile Arg Ser Thr Asn Ser Trp Phe Asp Val Thr Trp Arg 
    930                 935                 940                 


Thr Phe Thr Gly Asp Phe Leu Arg Arg Val Glu Glu Arg Phe Thr Lys 
945                 950                 955                 960 


Ser Lys Thr Leu Ser Leu Ile Gln Ser Tyr Ser Leu Leu Asp Lys Pro 
                965                 970                 975     


Asp Glu Ala Ile Glu Lys Val Phe Asn Ala Tyr Pro Ala Ala Arg Glu 
            980                 985                 990         


Gln Phe Leu Asn Ala Gln Asp Ile  Asp His Phe Leu Ser  Met Cys Gln 
        995                 1000                 1005             


Asn Pro  Met Gln Lys Pro Val  Pro Phe Val Pro Val  Leu Asp Arg 
    1010                 1015                 1020             


Arg Phe  Glu Ile Phe Phe Lys  Lys Asp Ser Leu Trp  Gln Ser Glu 
    1025                 1030                 1035             


His Leu  Glu Ala Val Val Asp  Gln Asp Val Gln Arg  Thr Cys Ile 
    1040                 1045                 1050             


Leu His  Gly Pro Val Ala Ala  Gln Phe Thr Lys Val  Ile Asp Glu 
    1055                 1060                 1065             


Pro Ile  Lys Ser Ile Met Asp  Gly Ile His Asp Gly  His Ile Lys 
    1070                 1075                 1080             


Lys Leu  Leu His Gln Tyr Tyr  Gly Asp Asp Glu Ser  Lys Ile Pro 
    1085                 1090                 1095             


Ala Val  Glu Tyr Phe Gly Gly  Glu Ser Pro Val Asp  Val Gln Ser 
    1100                 1105                 1110             


Gln Val  Asp Ser Ser Ser Val  Ser Glu Asp Ser Ala  Val Phe Lys 
    1115                 1120                 1125             


Ala Thr  Ser Ser Thr Asp Glu  Glu Ser Trp Phe Lys  Ala Leu Ala 
    1130                 1135                 1140             


Gly Ser  Glu Ile Asn Trp Arg  His Ala Ser Phe Leu  Cys Ser Phe 
    1145                 1150                 1155             


Ile Thr  Gln Asp Lys Met Phe  Val Ser Asn Pro Ile  Arg Lys Val 
    1160                 1165                 1170             


Phe Lys  Pro Ser Gln Gly Met  Val Val Glu Ile Ser  Asn Gly Asn 
    1175                 1180                 1185             


Thr Ser  Ser Lys Thr Val Val  Thr Leu Ser Glu Pro  Val Gln Gly 
    1190                 1195                 1200             


Glu Leu  Lys Pro Thr Val Ile  Leu Lys Leu Leu Lys  Glu Asn Ile 
    1205                 1210                 1215             


Ile Gln  Met Glu Met Ile Glu  Asn Arg Thr Met Asp  Gly Lys Pro 
    1220                 1225                 1230             


Val Ser  Leu Pro Leu Leu Tyr  Asn Phe Asn Pro Asp  Asn Gly Phe 
    1235                 1240                 1245             


Ala Pro  Ile Ser Glu Val Met  Glu Asp Arg Asn Gln  Arg Ile Lys 
    1250                 1255                 1260             


Glu Met  Tyr Trp Lys Leu Trp  Ile Asp Glu Pro Phe  Asn Leu Asp 
    1265                 1270                 1275             


Phe Asp  Pro Arg Asp Val Ile  Lys Gly Lys Asp Phe  Glu Ile Thr 
    1280                 1285                 1290             


Ala Lys  Glu Val Tyr Asp Phe  Thr His Ala Val Gly  Asn Asn Cys 
    1295                 1300                 1305             


Glu Asp  Phe Val Ser Arg Pro  Asp Arg Thr Met Leu  Ala Pro Met 
    1310                 1315                 1320             


Asp Phe  Ala Ile Val Val Gly  Trp Arg Ala Ile Ile  Lys Ala Ile 
    1325                 1330                 1335             


Phe Pro  Asn Thr Val Asp Gly  Asp Leu Leu Lys Leu  Val His Leu 
    1340                 1345                 1350             


Ser Asn  Gly Tyr Lys Met Ile  Pro Gly Ala Lys Pro  Leu Gln Val 
    1355                 1360                 1365             


Gly Asp  Val Val Ser Thr Thr  Ala Val Ile Glu Ser  Val Val Asn 
    1370                 1375                 1380             


Gln Pro  Thr Gly Lys Ile Val  Asp Val Val Gly Thr  Leu Ser Arg 
    1385                 1390                 1395             


Asn Gly  Lys Pro Val Met Glu  Val Thr Ser Ser Phe  Phe Tyr Arg 
    1400                 1405                 1410             


Gly Asn  Tyr Thr Asp Phe Glu  Asn Thr Phe Gln Lys  Thr Val Glu 
    1415                 1420                 1425             


Pro Val  Tyr Gln Met His Ile  Lys Thr Ser Lys Asp  Ile Ala Val 
    1430                 1435                 1440             


Leu Arg  Ser Lys Glu Trp Phe  Gln Leu Asp Asp Glu  Asp Phe Asp 
    1445                 1450                 1455             


Leu Leu  Asn Lys Thr Leu Thr  Phe Glu Thr Glu Thr  Glu Val Thr 
    1460                 1465                 1470             


Phe Lys  Asn Ala Asn Ile Phe  Ser Ser Val Lys Cys  Phe Gly Pro 
    1475                 1480                 1485             


Ile Lys  Val Glu Leu Pro Thr  Lys Glu Thr Val Glu  Ile Gly Ile 
    1490                 1495                 1500             


Val Asp  Tyr Glu Ala Gly Ala  Ser His Gly Asn Pro  Val Val Asp 
    1505                 1510                 1515             


Phe Leu  Lys Arg Asn Gly Ser  Thr Leu Glu Gln Lys  Val Asn Leu 
    1520                 1525                 1530             


Glu Asn  Pro Ile Pro Ile Ala  Val Leu Asp Ser Tyr  Thr Pro Ser 
    1535                 1540                 1545             


Thr Asn  Glu Pro Tyr Ala Arg  Val Ser Gly Asp Leu  Asn Pro Ile 
    1550                 1555                 1560             


His Val  Ser Arg His Phe Ala  Ser Tyr Ala Asn Leu  Pro Gly Thr 
    1565                 1570                 1575             


Ile Thr  His Gly Met Phe Ser  Ser Ala Ser Val Arg  Ala Leu Ile 
    1580                 1585                 1590             


Glu Asn  Trp Ala Ala Asp Ser  Val Ser Ser Arg Val  Arg Gly Tyr 
    1595                 1600                 1605             


Thr Cys  Gln Phe Val Asp Met  Val Leu Pro Asn Thr  Ala Leu Lys 
    1610                 1615                 1620             


Thr Ser  Ile Gln His Val Gly  Met Ile Asn Gly Arg  Lys Leu Ile 
    1625                 1630                 1635             


Lys Phe  Glu Thr Arg Asn Glu  Asp Asp Val Val Val  Leu Thr Gly 
    1640                 1645                 1650             


Glu Ala  Glu Ile Glu Gln Pro  Val Thr Thr Phe Val  Phe Thr Gly 
    1655                 1660                 1665             


Gln Gly  Ser Gln Glu Gln Gly  Met Gly Met Asp Leu  Tyr Lys Thr 
    1670                 1675                 1680             


Ser Lys  Ala Ala Gln Asp Val  Trp Asn Arg Ala Asp  Asn His Phe 
    1685                 1690                 1695             


Lys Asp  Thr Tyr Gly Phe Ser  Ile Leu Asp Ile Val  Ile Asn Asn 
    1700                 1705                 1710             


Pro Val  Asn Leu Thr Ile His  Phe Gly Gly Glu Lys  Gly Lys Arg 
    1715                 1720                 1725             


Ile Arg  Glu Asn Tyr Ser Ala  Met Ile Phe Glu Thr  Ile Val Asp 
    1730                 1735                 1740             


Gly Lys  Leu Lys Thr Glu Lys  Ile Phe Lys Glu Ile  Asn Glu His 
    1745                 1750                 1755             


Ser Thr  Ser Tyr Thr Phe Arg  Ser Glu Lys Gly Leu  Leu Ser Ala 
    1760                 1765                 1770             


Thr Gln  Phe Thr Gln Pro Ala  Leu Thr Leu Met Glu  Lys Ala Ala 
    1775                 1780                 1785             


Phe Glu  Asp Leu Lys Ser Lys  Gly Leu Ile Pro Ala  Asp Ala Thr 
    1790                 1795                 1800             


Phe Ala  Gly His Ser Leu Gly  Glu Tyr Ala Ala Leu  Ala Ser Leu 
    1805                 1810                 1815             


Ala Asp  Val Met Ser Ile Glu  Ser Leu Val Glu Val  Val Phe Tyr 
    1820                 1825                 1830             


Phe Gly  Met Thr Met Gln Val  Ala Val Pro Arg Asp  Glu Leu Gly 
    1835                 1840                 1845             


Arg Ser  Asn Tyr Gly Met Ile  Ala Ile Asn Pro Gly  Arg Val Ala 
    1850                 1855                 1860             


Ala Ser  Phe Ser Gln Glu Ala  Leu Gln Tyr Val Val  Glu Arg Val 
    1865                 1870                 1875             


Gly Lys  Arg Thr Gly Trp Leu  Val Glu Ile Val Asn  Tyr Asn Val 
    1880                 1885                 1890             


Glu Asn  Gln Gln Tyr Val Ala  Ala Gly Asp Leu Arg  Ala Leu Asp 
    1895                 1900                 1905             


Thr Val  Thr Asn Val Leu Asn  Phe Ile Lys Leu Gln  Lys Ile Asp 
    1910                 1915                 1920             


Ile Ile  Glu Leu Gln Lys Ser  Leu Ser Leu Glu Glu  Val Glu Gly 
    1925                 1930                 1935             


His Leu  Phe Glu Ile Ile Asp  Glu Ala Ser Lys Lys  Ser Ala Val 
    1940                 1945                 1950             


Lys Pro  Arg Pro Leu Lys Leu  Glu Arg Gly Phe Ala  Cys Ile Pro 
    1955                 1960                 1965             


Leu Val  Gly Ile Ser Val Pro  Phe His Ser Thr Tyr  Leu Met Asn 
    1970                 1975                 1980             


Gly Val  Lys Pro Phe Lys Ser  Phe Leu Lys Lys Asn  Ile Ile Lys 
    1985                 1990                 1995             


Glu Asn  Val Lys Val Ala Arg  Leu Ala Gly Lys Tyr  Ile Pro Asn 
    2000                 2005                 2010             


Leu Thr  Ala Lys Pro Phe Gln  Val Thr Lys Glu Tyr  Phe Gln Asp 
    2015                 2020                 2025             


Val Tyr  Asp Leu Thr Gly Ser  Glu Pro Ile Lys Glu  Ile Ile Asp 
    2030                 2035                 2040             


Asn Trp  Glu Lys Tyr Glu Gln  Ser 
    2045                 2050     


<210>  107
<211>  1887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated fatty acid synthase (FAS2, G1250S)

<400>  107

Met Lys Pro Glu Val Glu Gln Glu Leu Ala His Ile Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Phe Leu Lys Asp Phe Asn Thr Glu Arg Val Val Glu Ile Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Gln Arg Thr Leu Lys Asn Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu His Arg Glu Ile Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Ala Lys Glu Ile Tyr Tyr Thr Pro Asp Pro Ser Glu 
                85                  90                  95      


Leu Ala Ala Lys Glu Glu Pro Ala Lys Glu Glu Ala Pro Ala Pro Thr 
            100                 105                 110         


Pro Ala Ala Ser Ala Pro Ala Pro Ala Ala Ala Ala Pro Ala Pro Val 
        115                 120                 125             


Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Glu Ile Ala Asp Glu Pro 
    130                 135                 140                 


Val Lys Ala Ser Leu Leu Leu His Val Leu Val Ala His Lys Leu Lys 
145                 150                 155                 160 


Lys Ser Leu Asp Ser Ile Pro Met Ser Lys Thr Ile Lys Asp Leu Val 
                165                 170                 175     


Gly Gly Lys Ser Thr Val Gln Asn Glu Ile Leu Gly Asp Leu Gly Lys 
            180                 185                 190         


Glu Phe Gly Thr Thr Pro Glu Lys Pro Glu Glu Thr Pro Leu Glu Glu 
        195                 200                 205             


Leu Ala Glu Thr Phe Gln Asp Thr Phe Ser Gly Ala Leu Gly Lys Gln 
    210                 215                 220                 


Ser Ser Ser Leu Leu Ser Arg Leu Ile Ser Ser Lys Met Pro Gly Gly 
225                 230                 235                 240 


Phe Thr Ile Thr Val Ala Arg Lys Tyr Leu Gln Thr Arg Trp Gly Leu 
                245                 250                 255     


Pro Ser Gly Arg Gln Asp Gly Val Leu Leu Val Ala Leu Ser Asn Glu 
            260                 265                 270         


Pro Ala Ala Arg Leu Gly Ser Glu Ala Asp Ala Lys Ala Phe Leu Asp 
        275                 280                 285             


Ser Met Ala Gln Lys Tyr Ala Ser Ile Val Gly Val Asp Leu Ser Ser 
    290                 295                 300                 


Ala Ala Ser Ala Ser Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly Ala 
305                 310                 315                 320 


Ala Met Ile Asp Ala Gly Ala Leu Glu Glu Ile Thr Lys Asp His Lys 
                325                 330                 335     


Val Leu Ala Arg Gln Gln Leu Gln Val Leu Ala Arg Tyr Leu Lys Met 
            340                 345                 350         


Asp Leu Asp Asn Gly Glu Arg Lys Phe Leu Lys Glu Lys Asp Thr Val 
        355                 360                 365             


Ala Glu Leu Gln Ala Gln Leu Asp Tyr Leu Asn Ala Glu Leu Gly Glu 
    370                 375                 380                 


Phe Phe Val Asn Gly Val Ala Thr Ser Phe Ser Arg Lys Lys Ala Arg 
385                 390                 395                 400 


Thr Phe Asp Ser Ser Trp Asn Trp Ala Lys Gln Ser Leu Leu Ser Leu 
                405                 410                 415     


Tyr Phe Glu Ile Ile His Gly Val Leu Lys Asn Val Asp Arg Glu Val 
            420                 425                 430         


Val Ser Glu Ala Ile Asn Ile Met Asn Arg Ser Asn Asp Ala Leu Ile 
        435                 440                 445             


Lys Phe Met Glu Tyr His Ile Ser Asn Thr Asp Glu Thr Lys Gly Glu 
    450                 455                 460                 


Asn Tyr Gln Leu Val Lys Thr Leu Gly Glu Gln Leu Ile Glu Asn Cys 
465                 470                 475                 480 


Lys Gln Val Leu Asp Val Asp Pro Val Tyr Lys Asp Val Ala Lys Pro 
                485                 490                 495     


Thr Gly Pro Lys Thr Ala Ile Asp Lys Asn Gly Asn Ile Thr Tyr Ser 
            500                 505                 510         


Glu Glu Pro Arg Glu Lys Val Arg Lys Leu Ser Gln Tyr Val Gln Glu 
        515                 520                 525             


Met Ala Leu Gly Gly Pro Ile Thr Lys Glu Ser Gln Pro Thr Ile Glu 
    530                 535                 540                 


Glu Asp Leu Thr Arg Val Tyr Lys Ala Ile Ser Ala Gln Ala Asp Lys 
545                 550                 555                 560 


Gln Asp Ile Ser Ser Ser Thr Arg Val Glu Phe Glu Lys Leu Tyr Ser 
                565                 570                 575     


Asp Leu Met Lys Phe Leu Glu Ser Ser Lys Glu Ile Asp Pro Ser Gln 
            580                 585                 590         


Thr Thr Gln Leu Ala Gly Met Asp Val Glu Asp Ala Leu Asp Lys Asp 
        595                 600                 605             


Ser Thr Lys Glu Val Ala Ser Leu Pro Asn Lys Ser Thr Ile Ser Lys 
    610                 615                 620                 


Thr Val Ser Ser Thr Ile Pro Arg Glu Thr Ile Pro Phe Leu His Leu 
625                 630                 635                 640 


Arg Lys Lys Thr Pro Ala Gly Asp Trp Lys Tyr Asp Arg Gln Leu Ser 
                645                 650                 655     


Ser Leu Phe Leu Asp Gly Leu Glu Lys Ala Ala Phe Asn Gly Val Thr 
            660                 665                 670         


Phe Lys Asp Lys Tyr Val Leu Ile Thr Gly Ala Gly Lys Gly Ser Ile 
        675                 680                 685             


Gly Ala Glu Val Leu Gln Gly Leu Leu Gln Gly Gly Ala Lys Val Val 
    690                 695                 700                 


Val Thr Thr Ser Arg Phe Ser Lys Gln Val Thr Asp Tyr Tyr Gln Ser 
705                 710                 715                 720 


Ile Tyr Ala Lys Tyr Gly Ala Lys Gly Ser Thr Leu Ile Val Val Pro 
                725                 730                 735     


Phe Asn Gln Gly Ser Lys Gln Asp Val Glu Ala Leu Ile Glu Phe Ile 
            740                 745                 750         


Tyr Asp Thr Glu Lys Asn Gly Gly Leu Gly Trp Asp Leu Asp Ala Ile 
        755                 760                 765             


Ile Pro Phe Ala Ala Ile Pro Glu Gln Gly Ile Glu Leu Glu His Ile 
    770                 775                 780                 


Asp Ser Lys Ser Glu Phe Ala His Arg Ile Met Leu Thr Asn Ile Leu 
785                 790                 795                 800 


Arg Met Met Gly Cys Val Lys Lys Gln Lys Ser Ala Arg Gly Ile Glu 
                805                 810                 815     


Thr Arg Pro Ala Gln Val Ile Leu Pro Met Ser Pro Asn His Gly Thr 
            820                 825                 830         


Phe Gly Gly Asp Gly Met Tyr Ser Glu Ser Lys Leu Ser Leu Glu Thr 
        835                 840                 845             


Leu Phe Asn Arg Trp His Ser Glu Ser Trp Ala Asn Gln Leu Thr Val 
    850                 855                 860                 


Cys Gly Ala Ile Ile Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala 
865                 870                 875                 880 


Asn Asn Ile Ile Ala Glu Gly Ile Glu Lys Met Gly Val Arg Thr Phe 
                885                 890                 895     


Ser Gln Lys Glu Met Ala Phe Asn Leu Leu Gly Leu Leu Thr Pro Glu 
            900                 905                 910         


Val Val Glu Leu Cys Gln Lys Ser Pro Val Met Ala Asp Leu Asn Gly 
        915                 920                 925             


Gly Leu Gln Phe Val Pro Glu Leu Lys Glu Phe Thr Ala Lys Leu Arg 
    930                 935                 940                 


Lys Glu Leu Val Glu Thr Ser Glu Val Arg Lys Ala Val Ser Ile Glu 
945                 950                 955                 960 


Thr Ala Leu Glu His Lys Val Val Asn Gly Asn Ser Ala Asp Ala Ala 
                965                 970                 975     


Tyr Ala Gln Val Glu Ile Gln Pro Arg Ala Asn Ile Gln Leu Asp Phe 
            980                 985                 990         


Pro Glu Leu Lys Pro Tyr Lys Gln  Val Lys Gln Ile Ala  Pro Ala Glu 
        995                 1000                 1005             


Leu Glu  Gly Leu Leu Asp Leu  Glu Arg Val Ile Val  Val Thr Gly 
    1010                 1015                 1020             


Phe Ala  Glu Val Gly Pro Trp  Gly Ser Ala Arg Thr  Arg Trp Glu 
    1025                 1030                 1035             


Met Glu  Ala Phe Gly Glu Phe  Ser Leu Glu Gly Cys  Val Glu Met 
    1040                 1045                 1050             


Ala Trp  Ile Met Gly Phe Ile  Ser Tyr His Asn Gly  Asn Leu Lys 
    1055                 1060                 1065             


Gly Arg  Pro Tyr Thr Gly Trp  Val Asp Ser Lys Thr  Lys Glu Pro 
    1070                 1075                 1080             


Val Asp  Asp Lys Asp Val Lys  Ala Lys Tyr Glu Thr  Ser Ile Leu 
    1085                 1090                 1095             


Glu His  Ser Gly Ile Arg Leu  Ile Glu Pro Glu Leu  Phe Asn Gly 
    1100                 1105                 1110             


Tyr Asn  Pro Glu Lys Lys Glu  Met Ile Gln Glu Val  Ile Val Glu 
    1115                 1120                 1125             


Glu Asp  Leu Glu Pro Phe Glu  Ala Ser Lys Glu Thr  Ala Glu Gln 
    1130                 1135                 1140             


Phe Lys  His Gln His Gly Asp  Lys Val Asp Ile Phe  Glu Ile Pro 
    1145                 1150                 1155             


Glu Thr  Gly Glu Tyr Ser Val  Lys Leu Leu Lys Gly  Ala Thr Leu 
    1160                 1165                 1170             


Tyr Ile  Pro Lys Ala Leu Arg  Phe Asp Arg Leu Val  Ala Gly Gln 
    1175                 1180                 1185             


Ile Pro  Thr Gly Trp Asn Ala  Lys Thr Tyr Gly Ile  Ser Asp Asp 
    1190                 1195                 1200             


Ile Ile  Ser Gln Val Asp Pro  Ile Thr Leu Phe Val  Leu Val Ser 
    1205                 1210                 1215             


Val Val  Glu Ala Phe Ile Ala  Ser Gly Ile Thr Asp  Pro Tyr Glu 
    1220                 1225                 1230             


Met Tyr  Lys Tyr Val His Val  Ser Glu Val Gly Asn  Cys Ser Gly 
    1235                 1240                 1245             


Ser Ser  Met Gly Gly Val Ser  Ala Leu Arg Gly Met  Phe Lys Asp 
    1250                 1255                 1260             


Arg Phe  Lys Asp Glu Pro Val  Gln Asn Asp Ile Leu  Gln Glu Ser 
    1265                 1270                 1275             


Phe Ile  Asn Thr Met Ser Ala  Trp Val Asn Met Leu  Leu Ile Ser 
    1280                 1285                 1290             


Ser Ser  Gly Pro Ile Lys Thr  Pro Val Gly Ala Cys  Ala Thr Ser 
    1295                 1300                 1305             


Val Glu  Ser Val Asp Ile Gly  Val Glu Thr Ile Leu  Ser Gly Lys 
    1310                 1315                 1320             


Ala Arg  Ile Cys Ile Val Gly  Gly Tyr Asp Asp Phe  Gln Glu Glu 
    1325                 1330                 1335             


Gly Ser  Phe Glu Phe Gly Asn  Met Lys Ala Thr Ser  Asn Thr Leu 
    1340                 1345                 1350             


Glu Glu  Phe Glu His Gly Arg  Thr Pro Ala Glu Met  Ser Arg Pro 
    1355                 1360                 1365             


Ala Thr  Thr Thr Arg Asn Gly  Phe Met Glu Ala Gln  Gly Ala Gly 
    1370                 1375                 1380             


Ile Gln  Ile Ile Met Gln Ala  Asp Leu Ala Leu Lys  Met Gly Val 
    1385                 1390                 1395             


Pro Ile  Tyr Gly Ile Val Ala  Met Ala Ala Thr Ala  Thr Asp Lys 
    1400                 1405                 1410             


Ile Gly  Arg Ser Val Pro Ala  Pro Gly Lys Gly Ile  Leu Thr Thr 
    1415                 1420                 1425             


Ala Arg  Glu His His Ser Ser  Val Lys Tyr Ala Ser  Pro Asn Leu 
    1430                 1435                 1440             


Asn Met  Lys Tyr Arg Lys Arg  Gln Leu Val Thr Arg  Glu Ala Gln 
    1445                 1450                 1455             


Ile Lys  Asp Trp Val Glu Asn  Glu Leu Glu Ala Leu  Lys Leu Glu 
    1460                 1465                 1470             


Ala Glu  Glu Ile Pro Ser Glu  Asp Gln Asn Glu Phe  Leu Leu Glu 
    1475                 1480                 1485             


Arg Thr  Arg Glu Ile His Asn  Glu Ala Glu Ser Gln  Leu Arg Ala 
    1490                 1495                 1500             


Ala Gln  Gln Gln Trp Gly Asn  Asp Phe Tyr Lys Arg  Asp Pro Arg 
    1505                 1510                 1515             


Ile Ala  Pro Leu Arg Gly Ala  Leu Ala Thr Tyr Gly  Leu Thr Ile 
    1520                 1525                 1530             


Asp Asp  Leu Gly Val Ala Ser  Phe His Gly Thr Ser  Thr Lys Ala 
    1535                 1540                 1545             


Asn Asp  Lys Asn Glu Ser Ala  Thr Ile Asn Glu Met  Met Lys His 
    1550                 1555                 1560             


Leu Gly  Arg Ser Glu Gly Asn  Pro Val Ile Gly Val  Phe Gln Lys 
    1565                 1570                 1575             


Phe Leu  Thr Gly His Pro Lys  Gly Ala Ala Gly Ala  Trp Met Met 
    1580                 1585                 1590             


Asn Gly  Ala Leu Gln Ile Leu  Asn Ser Gly Ile Ile  Pro Gly Asn 
    1595                 1600                 1605             


Arg Asn  Ala Asp Asn Val Asp  Lys Ile Leu Glu Gln  Phe Glu Tyr 
    1610                 1615                 1620             


Val Leu  Tyr Pro Ser Lys Thr  Leu Lys Thr Asp Gly  Val Arg Ala 
    1625                 1630                 1635             


Val Ser  Ile Thr Ser Phe Gly  Phe Gly Gln Lys Gly  Gly Gln Ala 
    1640                 1645                 1650             


Ile Val  Val His Pro Asp Tyr  Leu Tyr Gly Ala Ile  Thr Glu Asp 
    1655                 1660                 1665             


Arg Tyr  Asn Glu Tyr Val Ala  Lys Val Ser Ala Arg  Glu Lys Ser 
    1670                 1675                 1680             


Ala Tyr  Lys Phe Phe His Asn  Gly Met Ile Tyr Asn  Lys Leu Phe 
    1685                 1690                 1695             


Val Ser  Lys Glu His Ala Pro  Tyr Thr Asp Glu Leu  Glu Glu Asp 
    1700                 1705                 1710             


Val Tyr  Leu Asp Pro Leu Ala  Arg Val Ser Lys Asp  Lys Lys Ser 
    1715                 1720                 1725             


Gly Ser  Leu Thr Phe Asn Ser  Lys Asn Ile Gln Ser  Lys Asp Ser 
    1730                 1735                 1740             


Tyr Ile  Asn Ala Asn Thr Ile  Glu Thr Ala Lys Met  Ile Glu Asn 
    1745                 1750                 1755             


Met Thr  Lys Glu Lys Val Ser  Asn Gly Gly Val Gly  Val Asp Val 
    1760                 1765                 1770             


Glu Leu  Ile Thr Ser Ile Asn  Val Glu Asn Asp Thr  Phe Ile Glu 
    1775                 1780                 1785             


Arg Asn  Phe Thr Pro Gln Glu  Ile Glu Tyr Cys Ser  Ala Gln Pro 
    1790                 1795                 1800             


Ser Val  Gln Ser Ser Phe Ala  Gly Thr Trp Ser Ala  Lys Glu Ala 
    1805                 1810                 1815             


Val Phe  Lys Ser Leu Gly Val  Lys Ser Leu Gly Gly  Gly Ala Ala 
    1820                 1825                 1830             


Leu Lys  Asp Ile Glu Ile Val  Arg Val Asn Lys Asn  Ala Pro Ala 
    1835                 1840                 1845             


Val Glu  Leu His Gly Asn Ala  Lys Lys Ala Ala Glu  Glu Ala Gly 
    1850                 1855                 1860             


Val Thr  Asp Val Lys Val Ser  Ile Ser His Asp Asp  Leu Gln Ala 
    1865                 1870                 1875             


Val Ala  Val Ala Val Ser Thr  Lys Lys 
    1880                 1885         


<210>  108
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBPtag

<400>  108

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Arg 
        355                 360                 365             


Ile Thr Lys 
    370     


<210>  109
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProA tag

<400>  109

Met Ile Phe Asp Gly Thr Thr Met Ser Ile Ala Ile Gly Leu Leu Ser 
1               5                   10                  15      


Thr Leu Gly Ile Gly Ala Glu Ala 
            20                  


<210>  110
<211>  398
<212>  PRT
<213>  Cannibis sativa

<400>  110

Met Gly Leu Ser Leu Val Cys Thr Phe Ser Phe Gln Thr Asn Tyr His 
1               5                   10                  15      


Thr Leu Leu Asn Pro His Asn Lys Asn Pro Lys Asn Ser Leu Leu Ser 
            20                  25                  30          


Tyr Gln His Pro Lys Thr Pro Ile Ile Lys Ser Ser Tyr Asp Asn Phe 
        35                  40                  45              


Pro Ser Lys Tyr Cys Leu Thr Lys Asn Phe His Leu Leu Gly Leu Asn 
    50                  55                  60                  


Ser His Asn Arg Ile Ser Ser Gln Ser Arg Ser Ile Arg Ala Gly Ser 
65                  70                  75                  80  


Asp Gln Ile Glu Gly Ser Pro His His Glu Ser Asp Asn Ser Ile Ala 
                85                  90                  95      


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
            100                 105                 110         


Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg 
        115                 120                 125             


Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys 
    130                 135                 140                 


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
145                 150                 155                 160 


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
                165                 170                 175     


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
            180                 185                 190         


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
        195                 200                 205             


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
    210                 215                 220                 


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe 
225                 230                 235                 240 


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
                245                 250                 255     


Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg 
            260                 265                 270         


Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr 
        275                 280                 285             


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
    290                 295                 300                 


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
305                 310                 315                 320 


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile 
                325                 330                 335     


Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser 
            340                 345                 350         


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
        355                 360                 365             


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
    370                 375                 380                 


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
385                 390                 395             


<210>  111
<211>  1197
<212>  DNA
<213>  Cannibis sativa

<400>  111
atgggtttat ctttggtctg caccttctcc tttcaaacta actaccacac tttattgaat       60

ccacataata agaatcctaa gaactcttta ttgtcctacc aacacccaaa gactcctatt      120

atcaagtcct cttacgataa cttcccatct aagtactgtt tgactaagaa tttccatttg      180

ttgggtttga attctcacaa cagaatttcc tcccaatccc gttctattag agccggttct      240

gatcaaatcg aaggttcccc tcatcatgag tccgataact ccattgctac taaaatttta      300

aatttcggtc atacttgttg gaagttgcaa cgtccttacg ttgtcaaggg tatgatctct      360

attgcttgtg gtttgttcgg tagagaattg tttaacaaca gacacttgtt ctcttggggt      420

ttgatgtgga aagctttctt cgctttggtc ccaattttgt ctttcaattt cttcgccgcc      480

atcatgaacc aaatctacga tgttgatatc gaccgtatca acaagccaga cttaccttta      540

gtttccggtg aaatgtccat tgaaactgct tggatcttgt ctatcattgt tgccttgact      600

ggtttaattg ttactattaa gttgaagtcc gctccattgt ttgtcttcat ctacatcttc      660

ggtatcttcg ctggtttcgc ttactccgtc ccacctatta gatggaaaca atatcctttt      720

accaatttct tgatcactat ttcctctcat gttggtttgg ctttcacttc ttactctgcc      780

accacttctg ctttaggttt gcctttcgtt tggcgtcctg ccttctcttt cattattgct      840

ttcatgactg tcatgggtat gactattgcc tttgctaaag acatttctga tatcgaaggt      900

gatgctaagt acggtgtctc taccgttgct accaagttag gtgctagaaa tatgactttt      960

gttgtttctg gtgtcttatt gttgaactac ttggtttcta tctctattgg tatcatttgg     1020

ccacaagttt tcaagtctaa cattatgatc ttgtctcatg ctattttggc tttctgtttg     1080

atctttcaaa ctcgtgaatt agccttagcc aattatgcct ctgccccatc ccgtcaattt     1140

ttcgaattca tctggttgtt atactatgcc gaatacttcg tttacgtctt catttaa        1197


<210>  112
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated acyl activating enzyme AAE (CsAAE3 truncation)

<400>  112

Met Glu Lys Ser Gly Tyr Gly Arg Asp Gly Ile Tyr Arg Ser Leu Arg 
1               5                   10                  15      


Pro Pro Leu His Leu Pro Asn Asn Asn Asn Leu Ser Met Val Ser Phe 
            20                  25                  30          


Leu Phe Arg Asn Ser Ser Ser Tyr Pro Gln Lys Pro Ala Leu Ile Asp 
        35                  40                  45              


Ser Glu Thr Asn Gln Ile Leu Ser Phe Ser His Phe Lys Ser Thr Val 
    50                  55                  60                  


Ile Lys Val Ser His Gly Phe Leu Asn Leu Gly Ile Lys Lys Asn Asp 
65                  70                  75                  80  


Trp Leu Ile Tyr Ala Pro Asn Ser Ile His Phe Pro Val Cys Phe Leu 
                85                  90                  95      


Gly Ile Ile Ala Ser Gly Ala Ile Ala Thr Thr Ser Asn Pro Leu Tyr 
            100                 105                 110         


Thr Val Ser Glu Leu Ser Lys Gln Val Lys Asp Ser Asn Pro Lys Leu 
        115                 120                 125             


Ile Ile Thr Val Pro Gln Leu Leu Glu Lys Val Lys Gly Phe Asn Leu 
    130                 135                 140                 


Pro Thr Ile Leu Ile Gly Pro Asp Ser Glu Gln Glu Ser Ser Ser Asp 
145                 150                 155                 160 


Lys Val Met Thr Phe Asn Asp Leu Val Asn Leu Gly Gly Ser Ser Gly 
                165                 170                 175     


Ser Glu Phe Pro Ile Val Asp Asp Phe Lys Gln Ser Asp Thr Ala Ala 
            180                 185                 190         


Leu Leu Tyr Ser Ser Gly Thr Thr Gly Met Ser Lys Gly Trp Leu Thr 
        195                 200                 205             


His Lys Asn Phe Ile Ala Ser Ser Leu Met Val Thr Met Glu Gln Asp 
    210                 215                 220                 


Leu Val Gly Glu Met Asp Asn Val Phe Leu Cys Phe Leu Pro Met Phe 
225                 230                 235                 240 


His Val Phe Gly Leu Ala Ile Ile Thr Tyr Ala Gln Leu Gln Arg Gly 
                245                 250                 255     


Asn Thr Val Ile Ser Ala Arg Phe Asp Leu Glu Lys Met Leu Lys Asp 
            260                 265                 270         


Val Glu Lys Tyr Val Thr His Leu Trp Trp Pro Pro Val Ile Leu Ala 
        275                 280                 285             


Leu Ser Lys Asn Ser Met Val Lys Phe Asn Leu Ser Ser Ile Lys Tyr 
    290                 295                 300                 


Ile Gly Ser Gly Ala Ala Pro Leu Gly Lys Asp Leu Met Glu Glu Cys 
305                 310                 315                 320 


Ser Lys Trp Pro Tyr Gly Ile Val Ala Gln Gly Tyr Gly Met Thr Glu 
                325                 330                 335     


Thr Cys Gly Ile Val Ser Met Glu Asp Ile Arg Gly Gly Lys Arg Asn 
            340                 345                 350         


Ser Gly Ser Ala Gly Met Leu Ala Ser Gly Val Glu Ala Gln Ile Val 
        355                 360                 365             


Ser Val Asp Thr Leu Lys Pro Leu Pro Pro Asn Gln Leu Gly Glu Ile 
    370                 375                 380                 


Trp Val Lys Gly Pro Asn Met Met Gln Gly Tyr Phe Asn Asn Pro Gln 
385                 390                 395                 400 


Ala Thr Lys Leu Thr Ile Asp Lys Lys Gly Trp Val His Thr Gly Asp 
                405                 410                 415     


Leu Gly Tyr Phe Asp Glu Asp Gly His Leu Tyr Trp Asp Arg Ile Lys 
            420                 425                 430         


Glu Leu Ile Lys Tyr Lys Gly Phe Gln Val Ala Pro Ala Glu Leu Glu 
        435                 440                 445             


Gly Leu Leu Val Ser His Pro Glu Ile Leu Asp Ala Trp Ile Pro Phe 
    450                 455                 460                 


Pro Asp Ala Glu Ala Gly Glu Val Pro Val Ala Tyr Trp Arg Ser Pro 
465                 470                 475                 480 


Asn Ser Ser Leu Thr Glu Asn Asp Val Lys Lys Phe Ile Ala Gly Gln 
                485                 490                 495     


Val Ala Ser Phe Lys Arg Leu Arg Lys Val Thr Phe Ile Asn Ser Val 
            500                 505                 510         


Pro Lys Ser Ala Ser Gly Lys Ile Leu Arg 
        515                 520         


<210>  113
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (tHMG1)

<400>  113

Met Ser Asp Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe Thr 
1               5                   10                  15      


Ala Pro Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr Val 
            20                  25                  30          


Ile Ser Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser Ser 
        35                  40                  45              


Ser Gly Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile Glu 
    50                  55                  60                  


Ser Leu Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu Leu 
65                  70                  75                  80  


Ser Ser Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala Leu 
                85                  90                  95      


Val Ile His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu Gly 
            100                 105                 110         


Asp Thr Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile Leu 
        115                 120                 125             


Ala Glu Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn Tyr 
    130                 135                 140                 


Asp Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr 
145                 150                 155                 160 


Met Pro Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly Thr 
                165                 170                 175     


Ser Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser 
            180                 185                 190         


Ala Met Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr 
        195                 200                 205             


Val Leu Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro 
    210                 215                 220                 


Thr Leu Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu 
225                 230                 235                 240 


Gly Gln Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala 
                245                 250                 255     


Arg Leu Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met 
            260                 265                 270         


Arg Phe Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser 
        275                 280                 285             


Lys Gly Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp 
    290                 295                 300                 


Glu Asp Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys 
305                 310                 315                 320 


Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val 
                325                 330                 335     


Ala Glu Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys Ser 
            340                 345                 350         


Asp Val Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val Gly 
        355                 360                 365             


Ser Ala Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn 
    370                 375                 380                 


Leu Val Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn 
385                 390                 395                 400 


Val Glu Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp 
                405                 410                 415     


Leu Arg Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly 
            420                 425                 430         


Gly Gly Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly 
        435                 440                 445             


Val Arg Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln Leu 
    450                 455                 460                 


Ala Arg Ile Val Ala Cys Ala Val Leu Ala Gly Glu Leu Ser Leu Cys 
465                 470                 475                 480 


Ala Ala Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn 
                485                 490                 495     


Arg Lys Pro Ala Glu Pro Thr Lys Pro Asn Asn Leu Asp Ala Thr Asp 
            500                 505                 510         


Ile Asn Arg Leu Lys Asp Gly Ser Val Thr Cys Ile Lys Ser 
        515                 520                 525     


<210>  114
<211>  1581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (tHMG1)

<400>  114
atgtccgatc aattagtcaa gaccgaagtc accaagaagt ccttcaccgc cccagttcaa       60

aaagcctcca ctccagtctt aactaacaag accgttattt ctggttccaa ggttaagtct      120

ttatcctccg ctcaatcctc ctcttccggt ccatcttctt cttctgaaga agatgattcc      180

cgtgacattg agtccttgga taagaaaatc agacctttgg aagaattaga agctttgtta      240

tcctctggta atactaagca attgaaaaac aaggaagttg ctgctttggt tattcacggt      300

aaattacctt tgtacgcttt agagaagaag ttaggtgaca ctacccgtgc tgtcgccgtt      360

agaagaaaag ctttgtctat tttagctgag gcccctgttt tggcttctga cagattacca      420

tacaagaatt acgattacga tagagttttc ggtgcctgtt gtgagaacgt tatcggttat      480

atgccattac cagtcggtgt tatcggtcca ttggttattg acggtacctc ttaccacatc      540

ccaatggcta ctactgaagg ttgtttagtc gcctccgcca tgagaggttg taaggctatc      600

aatgctggtg gtggtgctac taccgtcttg actaaggatg gtatgactag aggtccagtt      660

gtccgttttc caactttgaa aagatctggt gcttgtaaga tttggttgga ttctgaagaa      720

ggtcaaaatg ccattaagaa ggctttcaat tccacctcta gatttgccag attacaacat      780

attcaaacct gtttagccgg tgatttgttg ttcatgagat tcagaactac tactggtgat      840

gctatgggta tgaacatgat ctctaagggt gtcgaatatt ctttaaaaca aatggttgaa      900

gagtatggtt gggaagacat ggaggtcgtc tctgtctctg gtaactactg tactgataag      960

aaaccagctg ctatcaactg gatcgaaggt cgtggtaagt ctgttgttgc cgaagctact     1020

attccaggtg atgttgttag aaaggtttta aaatccgatg tctctgcctt ggttgagttg     1080

aacattgcta aaaacttggt tggttctgct atggctggtt ctgtcggtgg ttttaatgcc     1140

catgccgcca acttagtcac cgccgttttc ttagctttgg gtcaagatcc agctcaaaat     1200

gtcgaatcct ccaactgtat cactttgatg aaagaggtcg acggtgactt gcgtatctct     1260

gtttccatgc catctatcga agttggtact atcggtggtg gtactgtttt ggagccacaa     1320

ggtgctatgt tggacttatt gggtgttaga ggtccacacg ccactgctcc tggtaccaac     1380

gccagacaat tagctagaat cgttgcctgt gccgtcttag ctggtgagtt gtctttatgt     1440

gctgccttag ctgctggtca cttggtccaa tcccacatga ctcataacag aaagccagct     1500

gaacctacca agcctaacaa cttggatgcc accgatatta atcgtttaaa agatggttct     1560

gtcacttgca ttaagtccta a                                               1581


<210>  115
<211>  461
<212>  PRT
<213>  Saccharomyces sp.

<400>  115

Met Thr Glu Leu Lys Lys Gln Lys Thr Ala Glu Gln Lys Thr Arg Pro 
1               5                   10                  15      


Gln Asn Val Gly Ile Lys Gly Ile Gln Ile Tyr Ile Pro Thr Gln Cys 
            20                  25                  30          


Val Asn Gln Ser Glu Leu Glu Lys Phe Asp Gly Val Ser Gln Gly Lys 
        35                  40                  45              


Tyr Thr Ile Gly Leu Gly Gln Thr Asn Met Ser Phe Val Asn Asp Arg 
    50                  55                  60                  


Glu Asp Ile Tyr Ser Met Ser Leu Thr Val Leu Ser Lys Leu Ile Lys 
65                  70                  75                  80  


Ser Tyr Asn Ile Asp Thr Asn Lys Ile Gly Arg Leu Glu Val Gly Thr 
                85                  90                  95      


Glu Thr Leu Ile Asp Lys Ser Lys Ser Val Lys Ser Val Leu Met Gln 
            100                 105                 110         


Leu Phe Gly Glu Asn Thr Asp Val Glu Gly Ile Asp Thr Leu Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Asn Ala Leu Phe Asn Ser Leu Asn Trp Ile Glu 
    130                 135                 140                 


Ser Asn Ala Trp Asp Gly Arg Asp Ala Ile Val Val Cys Gly Asp Ile 
145                 150                 155                 160 


Ala Ile Tyr Asp Lys Gly Ala Ala Arg Pro Thr Gly Gly Ala Gly Thr 
                165                 170                 175     


Val Ala Met Trp Ile Gly Pro Asp Ala Pro Ile Val Phe Asp Ser Val 
            180                 185                 190         


Arg Ala Ser Tyr Met Glu His Ala Tyr Asp Phe Tyr Lys Pro Asp Phe 
        195                 200                 205             


Thr Ser Glu Tyr Pro Tyr Val Asp Gly His Phe Ser Leu Thr Cys Tyr 
    210                 215                 220                 


Val Lys Ala Leu Asp Gln Val Tyr Lys Ser Tyr Ser Lys Lys Ala Ile 
225                 230                 235                 240 


Ser Lys Gly Leu Val Ser Asp Pro Ala Gly Ser Asp Ala Leu Asn Val 
                245                 250                 255     


Leu Lys Tyr Phe Asp Tyr Asn Val Phe His Val Pro Thr Cys Lys Leu 
            260                 265                 270         


Val Thr Lys Ser Tyr Gly Arg Leu Leu Tyr Asn Asp Phe Arg Ala Asn 
        275                 280                 285             


Pro Gln Leu Phe Pro Glu Val Asp Ala Glu Leu Ala Thr Arg Asp Tyr 
    290                 295                 300                 


Asp Glu Ser Leu Thr Asp Lys Asn Ile Glu Lys Thr Phe Val Asn Val 
305                 310                 315                 320 


Ala Lys Pro Phe His Lys Glu Arg Val Ala Gln Ser Leu Ile Val Pro 
                325                 330                 335     


Thr Asn Thr Gly Asn Met Tyr Thr Ala Ser Val Tyr Ala Ala Phe Ala 
            340                 345                 350         


Ser Leu Leu Asn Tyr Val Gly Ser Asp Asp Leu Gln Gly Lys Arg Val 
        355                 360                 365             


Gly Leu Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Leu Tyr Ser Cys 
    370                 375                 380                 


Lys Ile Val Gly Asp Val Gln His Ile Ile Lys Glu Leu Asp Ile Thr 
385                 390                 395                 400 


Asn Lys Leu Ala Lys Arg Ile Thr Glu Thr Pro Lys Asp Tyr Glu Ala 
                405                 410                 415     


Ala Ile Glu Leu Arg Glu Asn Ala His Leu Lys Lys Asn Phe Lys Pro 
            420                 425                 430         


Gln Gly Ser Ile Glu His Leu Gln Ser Gly Val Tyr Tyr Leu Thr Asn 
        435                 440                 445             


Ile Asp Asp Lys Phe Arg Arg Ser Tyr Asp Val Lys Lys 
    450                 455                 460     


<210>  116
<211>  1386
<212>  DNA
<213>  Saccharomyces sp.

<400>  116
atgaccgaat tgaagaagca aaagactgct gaacaaaaaa cccgtccaca aaatgttggt       60

atcaagggta ttcaaatcta cattccaact caatgcgtca accaatctga attggaaaaa      120

tttgatggtg tttctcaagg taaatacact attggtttgg gtcaaactaa tatgtccttc      180

gttaacgaca gagaagatat ttactccatg tccttgaccg tcttgtccaa attgattaag      240

tcttataata ttgacaccaa caagatcggt agattggaag ttggtactga aactttgatt      300

gataagtcta agtctgttaa gtctgtttta atgcaattgt tcggtgaaaa tactgacgtt      360

gaaggtattg acactttgaa cgcttgttac ggtggtacta atgctttatt taactctttg      420

aactggattg aatccaacgc ttgggacggt agagatgcca ttgtcgtttg tggtgacatt      480

gctatctatg acaagggtgc cgctcgtcca actggtggtg ctggtaccgt tgctatgtgg      540

atcggtcctg acgccccaat cgtttttgat tctgttcgtg cttcttacat ggagcatgct      600

tacgactttt ataagccaga ctttacctcc gaatatccat acgtcgatgg tcatttctct      660

ttgacctgct acgttaaagc cttagatcaa gtctacaagt cttactccaa gaaggccatt      720

tccaagggtt tagtctccga tccagctggt tccgatgctt taaacgtttt aaagtacttc      780

gattacaacg tttttcatgt ccctacttgt aaattggtta ccaaatctta cggtagatta      840

ttgtacaacg atttcagagc taatccacaa ttatttccag aagtcgatgc tgagttggct      900

actagagatt acgacgaatc cttgaccgac aaaaatattg aaaagacttt tgttaacgtt      960

gctaagccat ttcacaaaga gagagttgcc caatctttga ttgtcccaac taatactggt     1020

aatatgtata ctgcttctgt ttacgctgcc tttgcttctt tgttgaacta tgtcggttct     1080

gacgacttac aaggtaagcg tgtcggtttg ttctcctacg gttccggttt ggctgcctct     1140

ttgtattctt gtaagattgt cggtgatgtt caacacatca tcaaggaatt ggatatcacc     1200

aataaattgg ccaagagaat cactgaaact cctaaagact atgaagctgc tatcgaattg     1260

agagaaaatg ctcatttaaa gaaaaacttt aaaccacaag gttctattga acacttgcaa     1320

tccggtgttt actacttaac taacatcgat gacaagttcc gtagatccta cgacgtcaag     1380

aagtaa                                                                1386


<210>  117
<211>  568
<212>  PRT
<213>  Zymomonas mobilis

<400>  117

Met Ser Tyr Thr Val Gly Thr Tyr Leu Ala Glu Arg Leu Val Gln Ile 
1               5                   10                  15      


Gly Leu Lys His His Phe Ala Val Ala Gly Asp Tyr Asn Leu Val Leu 
            20                  25                  30          


Leu Asp Asn Leu Leu Leu Asn Lys Asn Met Glu Gln Val Tyr Cys Cys 
        35                  40                  45              


Asn Glu Leu Asn Cys Gly Phe Ser Ala Glu Gly Tyr Ala Arg Ala Lys 
    50                  55                  60                  


Gly Ala Ala Ala Ala Val Val Thr Tyr Ser Val Gly Ala Leu Ser Ala 
65                  70                  75                  80  


Phe Asp Ala Ile Gly Gly Ala Tyr Ala Glu Asn Leu Pro Val Ile Leu 
                85                  90                  95      


Ile Ser Gly Ala Pro Asn Asn Asn Asp His Ala Ala Gly His Val Leu 
            100                 105                 110         


His His Ala Leu Gly Lys Thr Asp Tyr His Tyr Gln Leu Glu Met Ala 
        115                 120                 125             


Lys Asn Ile Thr Ala Ala Ala Glu Ala Ile Tyr Thr Pro Glu Glu Ala 
    130                 135                 140                 


Pro Ala Lys Ile Asp His Val Ile Lys Thr Ala Leu Arg Glu Lys Lys 
145                 150                 155                 160 


Pro Val Tyr Leu Glu Ile Ala Cys Asn Ile Ala Ser Met Pro Cys Ala 
                165                 170                 175     


Ala Pro Gly Pro Ala Ser Ala Leu Phe Asn Asp Glu Ala Ser Asp Glu 
            180                 185                 190         


Ala Ser Leu Asn Ala Ala Val Glu Glu Thr Leu Lys Phe Ile Ala Asn 
        195                 200                 205             


Arg Asp Lys Val Ala Val Leu Val Gly Ser Lys Leu Arg Ala Ala Gly 
    210                 215                 220                 


Ala Glu Glu Ala Ala Val Lys Phe Ala Asp Ala Leu Gly Gly Ala Val 
225                 230                 235                 240 


Ala Thr Met Ala Ala Ala Lys Ser Phe Phe Pro Glu Glu Asn Pro His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Trp Gly Glu Val Ser Tyr Pro Gly Val Glu Lys 
            260                 265                 270         


Thr Met Lys Glu Ala Asp Ala Val Ile Ala Leu Ala Pro Val Phe Asn 
        275                 280                 285             


Asp Tyr Ser Thr Thr Gly Trp Thr Asp Ile Pro Asp Pro Lys Lys Leu 
    290                 295                 300                 


Val Leu Ala Glu Pro Arg Ser Val Val Val Asn Gly Ile Arg Phe Pro 
305                 310                 315                 320 


Ser Val His Leu Lys Asp Tyr Leu Thr Arg Leu Ala Gln Lys Val Ser 
                325                 330                 335     


Lys Lys Thr Gly Ala Leu Asp Phe Phe Lys Ser Leu Asn Ala Gly Glu 
            340                 345                 350         


Leu Lys Lys Ala Ala Pro Ala Asp Pro Ser Ala Pro Leu Val Asn Ala 
        355                 360                 365             


Glu Ile Ala Arg Gln Val Glu Ala Leu Leu Thr Pro Asn Thr Thr Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Asp Ser Trp Phe Asn Ala Gln Arg Met Lys Leu 
385                 390                 395                 400 


Pro Asn Gly Ala Arg Val Glu Tyr Glu Met Gln Trp Gly His Ile Gly 
                405                 410                 415     


Trp Ser Val Pro Ala Ala Phe Gly Tyr Ala Val Gly Ala Pro Glu Arg 
            420                 425                 430         


Arg Asn Ile Leu Met Val Gly Asp Gly Ser Phe Gln Leu Thr Ala Gln 
        435                 440                 445             


Glu Val Ala Gln Met Val Arg Leu Lys Leu Pro Val Ile Ile Phe Leu 
    450                 455                 460                 


Ile Asn Asn Tyr Gly Tyr Thr Ile Glu Val Met Ile His Asp Gly Pro 
465                 470                 475                 480 


Tyr Asn Asn Ile Lys Asn Trp Asp Tyr Ala Gly Leu Met Glu Val Phe 
                485                 490                 495     


Asn Gly Asn Gly Gly Tyr Asp Ser Gly Ala Gly Lys Gly Leu Lys Ala 
            500                 505                 510         


Lys Thr Gly Gly Glu Leu Ala Glu Ala Ile Lys Val Ala Leu Ala Asn 
        515                 520                 525             


Thr Asp Gly Pro Thr Leu Ile Glu Cys Phe Ile Gly Arg Glu Asp Cys 
    530                 535                 540                 


Thr Glu Glu Leu Val Lys Trp Gly Lys Arg Val Ala Ala Ala Asn Ser 
545                 550                 555                 560 


Arg Lys Pro Val Asn Lys Leu Leu 
                565             


<210>  118
<211>  1707
<212>  DNA
<213>  Zymomonas mobilis

<400>  118
atgtcctaca ccgttggtac ctacttagct gagcgtttgg tccaaatcgg tttgaagcac       60

catttcgccg ttgctggtga ttacaacttg gtcttgttag ataatttatt attgaacaag      120

aacatggaac aagtctactg ctgtaatgaa ttgaactgtg gtttctctgc tgaaggttat      180

gctagagcta aaggtgccgc tgccgctgtt gtcacttact ctgttggtgc tttgtctgcc      240

ttcgacgcta ttggtggtgc ttacgccgag aatttacctg ttattttaat ttctggtgcc      300

cctaacaata acgatcatgc tgctggtcat gttttacacc acgctttggg taaaactgac      360

taccattatc aattagagat ggccaaaaac atcaccgccg ctgccgaggc catttacact      420

ccagaagaag ccccagccaa aattgatcac gtcatcaaaa ccgccttgag agagaaaaaa      480

cctgtttact tggaaatcgc ctgtaatatc gcctctatgc cttgcgccgc tcctggtcct      540

gcttccgcct tattcaacga tgaggcttct gatgaagctt ccttaaacgc tgctgttgag      600

gagactttaa agttcatcgc taatagagat aaggtcgctg ttttagtcgg ttctaagttg      660

cgtgctgccg gtgccgagga agctgctgtt aaattcgccg atgctttagg tggtgctgtc      720

gccaccatgg ccgccgccaa atcctttttc cctgaagaaa acccacacta catcggtact      780

tcttggggtg aagtctctta cccaggtgtc gaaaagacta tgaaggaagc cgatgccgtc      840

atcgccttgg ccccagtttt taatgattat tccaccactg gttggactga tatcccagat      900

cctaaaaagt tagttttagc cgagcctaga tccgttgttg ttaacggtat tagattccct      960

tccgttcact tgaaggatta cttaactaga ttggctcaaa aggtttccaa gaagaccggt     1020

gctttggact ttttcaaatc tttgaacgcc ggtgagttaa agaaggccgc ccctgctgac     1080

ccatctgctc cattggttaa cgctgagatt gctagacaag tcgaagcttt attgacccca     1140

aacactaccg ttatcgccga aactggtgac tcttggttta atgctcaaag aatgaagtta     1200

ccaaatggtg ccagagttga gtacgaaatg caatggggtc atatcggttg gtctgtccca     1260

gctgcttttg gttatgctgt tggtgcccct gagagaagaa acatcttgat ggttggtgac     1320

ggttccttcc aattgactgc tcaagaagtc gctcaaatgg ttagattaaa attaccagtc     1380

atcatcttct tgatcaataa ctacggttac actatcgaag tcatgattca cgatggtcct     1440

tacaataata ttaagaactg ggactatgct ggtttgatgg aagtctttaa tggtaacggt     1500

ggttacgatt ccggtgctgg taagggttta aaggctaaga ctggtggtga attagctgaa     1560

gccattaagg ttgccttggc taacaccgac ggtcctactt taatcgaatg tttcattggt     1620

agagaggatt gtaccgaaga gttagttaag tggggtaaga gagttgccgc tgctaattcc     1680

cgtaagcctg tcaataaatt gttataa                                         1707


<210>  119
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (tHMG1)

<400>  119
atgcaattgg tgaagactga agtcaccaag aagtctttta ctgctcctgt acaaaaggct       60

tctacaccag ttttaaccaa taaaacagtc atttctggat cgaaagtcaa aagtttatca      120

tctgcgcaat cgagctcatc aggaccttca tcatctagtg aggaagatga ttcccgcgat      180

attgaaagct tggataagaa aatacgtcct ttagaagaat tagaagcatt attaagtagt      240

ggaaatacaa aacaattgaa gaacaaagag gtcgctgcct tggttattca cggtaagtta      300

cctttgtacg ctttggagaa aaaattaggt gatactacga gagcggttgc ggtacgtagg      360

aaggctcttt caattttggc agaagctcct gtattagcat ctgatcgttt accatataaa      420

aattatgact acgaccgcgt atttggcgct tgttgtgaaa atgttatagg ttacatgcct      480

ttgcccgttg gtgttatagg ccccttggtt atcgatggta catcttatca tataccaatg      540

gcaactacag agggttgttt ggtagcttct gccatgcgtg gctgtaaggc aatcaatgct      600

ggcggtggtg caacaactgt tttaactaag gatggtatga caagaggccc agtagtccgt      660

ttcccaactt tgaaaagatc tggtgcctgt aagatatggt tagactcaga agagggacaa      720

aacgcaatta aaaaagcttt taactctaca tcaagatttg cacgtctgca acatattcaa      780

acttgtctag caggagattt actcttcatg agatttagaa caactactgg tgacgcaatg      840

ggtatgaata tgatttctaa gggtgtcgaa tactcattaa agcaaatggt agaagagtat      900

ggctgggaag atatggaggt tgtctccgtt tctggtaact actgtaccga caaaaaacca      960

gctgccatca actggatcga aggtcgtggt aagagtgtcg tcgcagaagc tactattcct     1020

ggtgatgttg tcagaaaagt gttaaaaagt gatgtttccg cattggttga gttgaacatt     1080

gctaagaatt tggttggatc tgcaatggct gggtctgttg gtggatttaa cgcacatgca     1140

gctaatttag tgacagctgt tttcttggca ttaggacaag atcctgcaca aaatgtcgaa     1200

agttccaact gtataacatt gatgaaagaa gtggacggtg atttgagaat ttccgtatcc     1260

atgccatcca tcgaagtagg taccatcggt ggtggtactg ttctagaacc acaaggtgcc     1320

atgttggact tattaggtgt aagaggccca catgctaccg ctcctggtac caacgcacgt     1380

caattagcaa gaatagttgc ctgtgccgtc ttggcaggtg aattatcctt atgtgctgcc     1440

ctagcagccg gccatttggt tcaaagtcat atgacccaca acaggaaacc tgctgaacca     1500

acaaaaccta acaatttgga cgccactgat ataaatcgtt tgaaagatgg gtccgtcacc     1560

tgcattaaat cctaa                                                      1575


<210>  120
<211>  1387
<212>  DNA
<213>  Saccharomyces sp.

<400>  120
atgactgaac taaaaaaaca aaagaccgct gaacaaaaaa ccagacctca aaatgtcggt       60

attaaaggta tccaaattta catcccaact caatgtgtca accaatctga gctagagaaa      120

tttgatggcg tttctcaagg taaatacaca attggtctgg gccaaaccaa catgtctttt      180

gtcaatgaca gagaagatat ctactcgatg tccctaactg ttttgtctaa gttgatcaag      240

agttacaaca tcgacaccaa caaaattggt agattagaag tcggtactga aactctgatt      300

gacaagtcca agtctgtcaa gtctgtcttg atgcaattgt ttggtgaaaa cactgacgtc      360

gaaggtattg acacgcttaa tgcctgttac ggtggtacca acgcgttgtt caactctttg      420

aactggattg aatctaacgc atgggatggt agagacgcca ttgtagtttg cggtgatatt      480

gccatctacg ataagggtgc cgcaagacca accggtggtg ccggtactgt tgctatgtgg      540

atcggtcctg atgctccaat tgtatttgac tctgtaagag cttcttacat ggaacacgcc      600

tacgattttt acaagccaga tttcaccagc gaatatcctt acgtcgatgg tcatttttca      660

ttaacttgtt acgtcaaggc tcttgatcaa gtttacaaga gttattccaa gaaggctatt      720

tctaaagggt tggttagcga tcccgctggt tcggatgctt tgaacgtttt gaaatatttc      780

gactacaacg ttttccatgt tccaacctgt aaattggtca caaaatcata cggtagatta      840

ctatataacg atttcagagc caatcctcaa ttgttcccag aagttgacgc cgaattagct      900

actcgcgatt atgacgaatc tttaaccgat aagaacattg aaaaaacttt tgttaatgtt      960

gctaagccat tccacaaaga gagagttgcc caatctttga ttgttccaac aaacacaggt     1020

aacatgtaca ccgcatctgt ttatgccgcc tttgcatctc tattaaacta tgttggatct     1080

gacgacttac aaggcaagcg tgttggttta ttttcttacg gttccggttt agctgcatct     1140

ctatattctt gcaaaattgt tggtgacgtc caacatatta tcaaggaatt agatattact     1200

aacaaattag ccaagagaat caccgaaact ccaaaggatt acgaagctgc catcgaattg     1260

agagaaaatg cccatttgaa gaagaacttc aaacctcaag gttccattga gcatttgcaa     1320

agtggtgttt actacttgac caacatcgat gacaaattta gaagatctta cgatgttaaa     1380

aaataat                                                               1387


<210>  121
<211>  420
<212>  PRT
<213>  Catharanthus sp.

<400>  121

Met Leu Phe Ser Arg Gly Leu Tyr Arg Ile Ala Arg Thr Ser Leu Asn 
1               5                   10                  15      


Arg Ser Arg Leu Leu Tyr Pro Leu Gln Ser Gln Ser Pro Glu Leu Leu 
            20                  25                  30          


Gln Ser Phe Gln Phe Arg Ser Pro Ile Gly Ser Ser Gln Lys Val Ser 
        35                  40                  45              


Gly Phe Arg Val Ile Tyr Ser Cys Val Ser Ser Ala Leu Ala Asn Val 
    50                  55                  60                  


Gly Gln Gln Val Gln Arg Gln Ser Asn Ser Val Ala Glu Glu Pro Leu 
65                  70                  75                  80  


Asp Pro Phe Ser Leu Val Ala Asp Glu Leu Ser Ile Leu Ala Asn Arg 
                85                  90                  95      


Leu Arg Ser Met Val Val Ala Glu Val Pro Lys Leu Ala Ser Ala Ala 
            100                 105                 110         


Glu Tyr Phe Phe Lys Leu Gly Val Glu Gly Lys Arg Phe Arg Pro Thr 
        115                 120                 125             


Val Leu Leu Leu Met Ala Thr Ala Ile Asp Ala Pro Ile Ser Arg Thr 
    130                 135                 140                 


Pro Pro Asp Thr Ser Leu Asp Thr Leu Ser Thr Glu Leu Arg Leu Arg 
145                 150                 155                 160 


Gln Gln Ser Ile Ala Glu Ile Thr Glu Met Ile His Val Ala Ser Leu 
                165                 170                 175     


Leu His Asp Asp Val Leu Asp Asp Ala Glu Thr Arg Arg Gly Ile Gly 
            180                 185                 190         


Ser Leu Asn Phe Val Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp 
        195                 200                 205             


Phe Leu Leu Ser Arg Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr 
    210                 215                 220                 


Glu Val Val Ser Leu Leu Ala Thr Val Val Glu His Leu Val Thr Gly 
225                 230                 235                 240 


Glu Thr Met Gln Met Thr Thr Thr Ser Asp Gln Arg Cys Ser Met Glu 
                245                 250                 255     


Tyr Tyr Met Gln Lys Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asn 
            260                 265                 270         


Ser Cys Lys Ala Ile Ala Leu Leu Ala Gly Gln Thr Ser Glu Val Ala 
        275                 280                 285             


Met Leu Ala Tyr Glu Tyr Gly Lys Asn Leu Gly Leu Ala Phe Gln Leu 
    290                 295                 300                 


Ile Asp Asp Val Leu Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly Lys 
305                 310                 315                 320 


Gly Ser Leu Ser Asp Ile Arg His Gly Ile Val Thr Ala Pro Ile Leu 
                325                 330                 335     


Phe Ala Ile Glu Glu Phe Pro Glu Leu Arg Ala Val Val Asp Glu Gly 
            340                 345                 350         


Phe Glu Asn Pro Tyr Asn Val Asp Leu Ala Leu His Tyr Leu Gly Lys 
        355                 360                 365             


Ser Arg Gly Ile Gln Arg Thr Arg Glu Leu Ala Ile Lys His Ala Asn 
    370                 375                 380                 


Leu Ala Ser Asp Ala Ile Asp Ser Leu Pro Val Thr Asp Asp Glu His 
385                 390                 395                 400 


Val Leu Arg Ser Arg Arg Ala Leu Val Glu Leu Thr Gln Arg Val Ile 
                405                 410                 415     


Thr Arg Arg Lys 
            420 


<210>  122
<211>  1263
<212>  DNA
<213>  Catharanthus sp.

<400>  122
atgttattct ctcgtggttt atacagaatc gccagaactt ctttgaacag atcccgtttg       60

ttgtaccctt tacaatctca atctcctgaa ttgttacaat ccttccaatt cagatctcca      120

atcggttcct ctcaaaaggt ttccggtttc agagttatct actcctgcgt ttcctctgct      180

ttagctaacg ttggtcaaca agtccaaaga caatctaatt ccgttgctga agaacctttg      240

gacccattct ccttggttgc cgatgaatta tccattttag ctaacagatt gcgttctatg      300

gtcgtcgctg aagttccaaa gttagcctcc gccgccgaat atttcttcaa gttgggtgtc      360

gagggtaaaa gattcagacc aactgttttg ttgttaatgg ccaccgccat tgatgcccca      420

atctctagaa ccccacctga cacctcctta gatactttat ccaccgaatt gcgtttgaga      480

caacaatcta tcgccgaaat tactgaaatg attcatgtcg cttccttgtt gcacgatgat      540

gttttggatg atgctgaaac tagaagaggt attggttctt taaattttgt catgggtaac      600

aaattggctg ttttggccgg tgacttctta ttatctagag cttgtgttgc cttagcttct      660

ttgaaaaaca ctgaagtcgt ctccttgtta gccactgtcg ttgaacactt agttactggt      720

gagactatgc aaatgactac cacctccgat caaagatgtt ctatggaata ctacatgcaa      780

aagacctatt acaagactgc ctctttgatt tctaactcct gtaaagccat tgccttgtta      840

gctggtcaaa cttctgaagt tgccatgttg gcttacgaat acggtaaaaa cttgggtttg      900

gctttccaat tgattgatga tgttttggat ttcactggta cttctgcttc cttaggtaaa      960

ggttctttgt ctgatattcg tcacggtatc gttaccgccc caatcttgtt cgctattgaa     1020

gaattcccag agttaagagc tgttgttgac gaaggtttcg aaaaccctta caatgttgac     1080

ttagccttgc actacttggg taaatctaga ggtattcaac gtaccagaga attagccatt     1140

aaacatgcta acttagcctc tgacgccatt gactctttac cagtcactga tgatgagcac     1200

gtcttacgtt ccagacgtgc cttagttgaa ttgactcaaa gagttattac tagaagaaag     1260

taa                                                                   1263


<210>  123
<211>  421
<212>  PRT
<213>  Mangifera indica

<400>  123

Met Leu Phe Ser Tyr Gly Leu Ser Arg Ile Ser Ile Asn Pro Arg Ala 
1               5                   10                  15      


Ser Leu Leu Thr Cys Arg Trp Leu Leu Ser His Leu Thr Gly Ser Leu 
            20                  25                  30          


Ser Pro Ser Thr Ser Ser His Thr Ile Ser Asp Ser Val His Lys Val 
        35                  40                  45              


Trp Gly Cys Arg Glu Ala Tyr Thr Trp Ser Val Pro Ala Leu His Gly 
    50                  55                  60                  


Phe Arg His Gln Ile His His Gln Ser Ser Ser Leu Ile Glu Asp Gln 
65                  70                  75                  80  


Leu Asp Pro Phe Ser Leu Val Ala Asp Glu Leu Ser Leu Val Ala Asn 
                85                  90                  95      


Arg Leu Arg Ser Met Val Val Thr Glu Val Pro Lys Leu Ala Ser Ala 
            100                 105                 110         


Ala Glu Tyr Phe Phe Lys Met Gly Val Glu Gly Lys Arg Phe Arg Pro 
        115                 120                 125             


Ala Val Leu Leu Leu Met Ala Thr Ala Leu Asn Val His Val Leu Glu 
    130                 135                 140                 


Pro Leu Pro Glu Gly Ala Gly Asp Ala Leu Met Thr Glu Leu Arg Thr 
145                 150                 155                 160 


Arg Gln Gln Cys Ile Ala Glu Ile Thr Glu Met Ile His Val Ala Ser 
                165                 170                 175     


Leu Leu His Asp Asp Val Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile 
            180                 185                 190         


Gly Ser Leu Asn Leu Val Met Gly Asn Lys Leu Ala Val Leu Ala Gly 
        195                 200                 205             


Asp Phe Leu Leu Ser Arg Ala Cys Val Ala Leu Ala Ser Leu Lys Asn 
    210                 215                 220                 


Thr Glu Val Val Ser Leu Leu Ala Thr Val Val Glu His Leu Val Thr 
225                 230                 235                 240 


Gly Glu Thr Met Gln Met Thr Thr Ser Ser Asp Gln Arg Cys Ser Met 
                245                 250                 255     


Glu Tyr Tyr Met Gln Lys Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser 
            260                 265                 270         


Asn Ser Cys Lys Ala Ile Ala Leu Leu Ala Gly Gln Ser Ala Glu Val 
        275                 280                 285             


Ala Met Leu Ala Phe Glu Phe Gly Lys Asn Leu Gly Leu Ala Tyr Gln 
    290                 295                 300                 


Leu Ile Asp Asp Val Leu Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly 
305                 310                 315                 320 


Lys Gly Ser Leu Ser Asp Ile Arg His Gly Ile Val Thr Ala Pro Ile 
                325                 330                 335     


Leu Phe Ala Met Glu Glu Phe Pro Gln Leu Arg Ala Val Ile Asp Gln 
            340                 345                 350         


Gly Phe Glu Asn Pro Ser Asn Val Asp Val Ala Leu Glu Tyr Leu Gly 
        355                 360                 365             


Lys Ser Arg Gly Ile Gln Arg Thr Arg Glu Leu Ala Thr Asn His Ala 
    370                 375                 380                 


Asn Leu Ala Ala Ala Ala Ile Asp Ala Leu Pro Lys Thr Asp Asn Glu 
385                 390                 395                 400 


Glu Val Arg Lys Ser Arg Arg Ala Leu Leu Asp Leu Thr Gln Arg Val 
                405                 410                 415     


Ile Thr Arg Asn Lys 
            420     


<210>  124
<211>  1266
<212>  DNA
<213>  Mangifera indica

<400>  124
atgttattct cttatggttt atctcgtatt tctattaacc ctcgtgcctc tttattgact       60

tgtagatggt tattatccca tttgactggt tctttatctc cttccacttc ttcccatact      120

atttctgact ccgtccataa agtctggggt tgcagagaag cctatacttg gtctgtccca      180

gctttacatg gttttagaca tcaaatccac catcaatcct cttccttgat tgaagatcaa      240

ttagacccat tctccttggt cgccgatgag ttgtccttgg ttgctaaccg tttaagatct      300

atggttgtca ctgaagtccc taaattagcc tctgccgccg aatacttttt caagatgggt      360

gtcgaaggta agcgtttcag accagctgtc ttgttgttaa tggccactgc cttaaacgtt      420

catgttttgg aacctttgcc tgaaggtgct ggtgacgctt taatgaccga gttgagaacc      480

cgtcaacaat gcattgctga aatcactgag atgatccacg tcgcctcttt attgcatgac      540

gatgttttag acgacgctga tactagaaga ggtattggtt ctttgaactt ggttatgggt      600

aacaaattgg ccgttttggc cggtgatttc ttgttatccc gtgcttgcgt tgctttagct      660

tctttgaaga acactgaagt tgtttctttg ttggccaccg tcgttgaaca cttagttact      720

ggtgagacta tgcaaatgac cacctcttct gaccaaagat gttccatgga atattacatg      780

caaaaaactt attacaaaac cgcctccttg atttctaact cctgtaaagc catcgcctta      840

ttagctggtc aatctgctga agttgccatg ttagccttcg agtttggtaa gaacttgggt      900

ttagcttacc aattgatcga tgatgtcttg gattttaccg gtacctctgc ttctttgggt      960

aagggttcct tgtccgacat tagacacggt attgttaccg ccccaatctt attcgctatg     1020

gaagagtttc cacaattgag agctgttatc gaccaaggtt tcgagaaccc atctaacgtt     1080

gacgtcgcct tagagtattt aggtaaatct agaggtatcc aacgtacccg tgaattagct     1140

actaaccatg ctaacttagc cgccgccgcc atcgatgcct tgcctaaaac cgataatgaa     1200

gaagtccgta agtccagacg tgctttatta gatttgactc aaagagtcat caccagaaac     1260

aaatag                                                                1266


<210>  125
<211>  328
<212>  PRT
<213>  Mangifera indica

<400>  125

Met Pro Phe Val Val Pro Arg Arg Asn Arg Ser Leu Ser Val Ser Ala 
1               5                   10                  15      


Val Leu Thr Lys Glu Glu Thr Leu Arg Glu Glu Glu Glu Asp Pro Lys 
            20                  25                  30          


Pro Val Phe Asp Phe Lys Ser Tyr Met Leu Gln Lys Gly Asn Ser Val 
        35                  40                  45              


Asn Gln Ala Leu Asp Ala Val Val Ser Ile Arg Glu Pro Lys Lys Ile 
    50                  55                  60                  


His Glu Ala Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg 
65                  70                  75                  80  


Pro Val Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Asn Glu Ser 
                85                  90                  95      


Met Ala Met Pro Ala Ala Cys Ala Val Glu Met Ile His Thr Met Ser 
            100                 105                 110         


Leu Ile His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Leu Arg Arg 
        115                 120                 125             


Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Val Ala Val Leu 
    130                 135                 140                 


Ala Gly Asp Ala Leu Leu Ala Phe Ser Phe Glu Asn Met Ala Val Ser 
145                 150                 155                 160 


Thr Val Gly Val Leu Pro Ser Arg Val Val Lys Ala Val Gly Glu Leu 
                165                 170                 175     


Ala Lys Ser Ile Gly Ile Glu Gly Leu Val Ala Gly Gln Val Val Asp 
            180                 185                 190         


Ile Asn Ser Glu Gly Leu Lys Glu Val Gly Leu Asp His Leu Glu Phe 
        195                 200                 205             


Ile His Gln His Lys Thr Ala Ala Leu Leu Glu Gly Ser Val Val Leu 
    210                 215                 220                 


Gly Ala Ile Leu Gly Gly Gly Ser Asp Asp Glu Val Glu Lys Leu Arg 
225                 230                 235                 240 


Thr Phe Ala Arg Cys Ile Gly Leu Leu Phe Gln Val Val Asp Asp Ile 
                245                 250                 255     


Leu Asp Val Thr Lys Ser Ser Arg Glu Leu Gly Lys Thr Ala Gly Lys 
            260                 265                 270         


Asp Leu Val Ala Asp Lys Val Thr Tyr Pro Lys Leu Leu Gly Ile Glu 
        275                 280                 285             


Lys Ser Arg Glu Leu Ala Asp Lys Leu Asn Lys Asp Ala Gln Gln Gln 
    290                 295                 300                 


Leu Ser Gly Phe Asp Gln Glu Lys Ala Ala Pro Leu Ile Ala Leu Ser 
305                 310                 315                 320 


Asn Tyr Ile Ala Tyr Arg Gln Asn 
                325             


<210>  126
<211>  987
<212>  DNA
<213>  Mangifera indica

<400>  126
atgccattcg ttgttcctag aagaaaccgt tctttgtccg tttccgccgt tttgaccaag       60

gaagaaactt taagagagga agaagaagat ccaaagccag ttttcgactt caaatcttac      120

atgttacaaa agggtaattc tgttaatcaa gctttggatg ctgtcgtttc cattagagaa      180

cctaagaaaa tccatgaggc tatgcgttac tctttgttgg ctggtggtaa gagagttcgt      240

cctgttttgt gtattgccgc ctgtgaattg gtcggtggta acgaatctat ggctatgcca      300

gccgcctgtg ctgtcgaaat gatccacact atgtccttga ttcacgatga tttgccatgt      360

atggataatg acgatttgcg tcgtggtaaa cctaccaacc ataaagtttt cggtgaagac      420

gtcgccgttt tggctggtga cgctttatta gctttttcct tcgagaacat ggccgtttcc      480

actgttggtg tcttaccatc cagagttgtc aaggctgttg gtgaattggc caagtctatc      540

ggtattgaag gtttggttgc cggtcaagtc gtcgatatta attctgaggg tttaaaagag      600

gtcggtttag atcacttaga atttatccat caacacaaaa ccgctgcttt gttggagggt      660

tctgttgttt tgggtgctat tttaggtggt ggttctgatg atgaagtcga aaagttgcgt      720

acctttgcta gatgtatcgg tttgttgttt caagttgttg acgatatttt ggatgtcact      780

aagtcttcca gagaattggg taagactgcc ggtaaagatt tggttgctga taaagttact      840

tatccaaagt tgttaggtat tgaaaagtct cgtgaattgg ccgataagtt aaacaaggat      900

gctcaacaac aattatccgg ttttgatcaa gagaaggctg cccctttaat cgctttgtcc      960

aattacatcg cctacagaca aaactag                                          987


<210>  127
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Cs2_GPPS_NTrunc

<400>  127

Met Val Ile Ala Glu Val Pro Lys Leu Ala Ser Ala Ala Glu Tyr Phe 
1               5                   10                  15      


Phe Lys Met Gly Val Glu Gly Lys Arg Phe Arg Pro Thr Val Leu Leu 
            20                  25                  30          


Leu Met Ala Thr Ala Leu Asn Val Arg Val Pro Glu Pro Leu His Asp 
        35                  40                  45              


Gly Val Glu Asp Ala Ser Ala Thr Glu Leu Arg Thr Arg Gln Gln Cys 
    50                  55                  60                  


Ile Ala Glu Ile Thr Glu Met Ile His Val Ala Ser Leu Leu His Asp 
65                  70                  75                  80  


Asp Val Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile Gly Ser Leu Asn 
                85                  90                  95      


Phe Val Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp Phe Leu Leu 
            100                 105                 110         


Ser Arg Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr Glu Val Val 
        115                 120                 125             


Thr Leu Leu Ala Thr Val Val Glu His Leu Val Thr Gly Glu Thr Met 
    130                 135                 140                 


Gln Met Thr Thr Ser Ser Asp Gln Arg Cys Ser Met Asp Tyr Tyr Met 
145                 150                 155                 160 


Gln Lys Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asn Ser Cys Lys 
                165                 170                 175     


Ala Ile Ala Leu Leu Ala Gly Gln Thr Ala Glu Val Ala Ile Leu Ala 
            180                 185                 190         


Phe Asp Tyr Gly Lys Asn Leu Gly Leu Ala Tyr Gln Leu Ile Asp Asp 
        195                 200                 205             


Val Leu Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly Lys Gly Ser Leu 
    210                 215                 220                 


Ser Asp Ile Arg His Gly Ile Ile Thr Ala Pro Ile Leu Phe Ala Met 
225                 230                 235                 240 


Glu Glu Phe Pro Gln Leu Arg Thr Val Val Glu Gln Gly Phe Glu Asp 
                245                 250                 255     


Ser Ser Asn Val Asp Ile Ala Leu Glu Tyr Leu Gly Lys Ser Arg Gly 
            260                 265                 270         


Ile Gln Lys Thr Arg Glu Leu Ala Val Lys His Ala Asn Leu Ala Ala 
        275                 280                 285             


Ala Ala Ile Asp Ser Leu Pro Glu Asn Asn Asp Glu Asp Val Thr Lys 
    290                 295                 300                 


Ser Arg Arg Ala Leu Leu Asp Leu Thr His Arg Val Ile Thr Arg Asn 
305                 310                 315                 320 


Lys 
    


<210>  128
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Cs2_GPPS_NTrunc

<400>  128
atggtcattg ctgaagttcc taaattagcc tctgccgccg aatacttctt caagatgggt       60

gtcgagggta agagatttcg tcctaccgtt ttgttgttaa tggccaccgc cttaaacgtc      120

agagtccctg aaccattaca tgatggtgtt gaagatgcct ctgccaccga gttgagaact      180

agacaacaat gtattgctga aatcaccgag atgattcacg ttgcctcttt gttgcacgat      240

gatgttttgg atgatgctga tacccgtcgt ggtatcggtt ctttgaactt tgtcatgggt      300

aacaagttgg ctgtcttggc tggtgatttc ttattgtctc gtgcctgcgt tgccttagcc      360

tctttaaaaa ataccgaagt tgttacttta ttggccactg ttgttgagca cttggttact      420

ggtgaaacta tgcaaatgac cacctcttcc gaccaacgtt gttccatgga ctattacatg      480

caaaagacct actacaagac cgcttctttg atttccaatt cttgtaaagc cattgcctta      540

ttagctggtc aaactgctga agttgccatc ttggccttcg actacggtaa aaacttgggt      600

ttagcttacc aattgattga tgacgtttta gattttactg gtacttctgc ttctttgggt      660

aaaggttctt tatccgatat tcgtcatggt atcattaccg ctccaatctt attcgctatg      720

gaagaatttc ctcaattgcg tactgtcgtt gaacaaggtt tcgaagactc ctccaacgtt      780

gacattgcct tagaatactt gggtaagtct cgtggtattc aaaagacccg tgaattagcc      840

gttaaacatg ccaacttagc cgccgccgcc atcgattcct tgcctgaaaa caacgatgag      900

gatgtcacca agtcccgtcg tgctttgtta gatttaactc acagagttat tacccgtaac      960

aagtaa                                                                 966


<210>  129
<211>  416
<212>  PRT
<213>  Quercus sp.

<400>  129

Met Leu Phe Ser Arg Ile Ser Arg Ile Arg Arg Pro Gly Ser Asn Gly 
1               5                   10                  15      


Phe Arg Trp Phe Leu Ser His Lys Thr His Leu Gln Phe Leu Asn Pro 
            20                  25                  30          


Pro Ala Tyr Ser Tyr Ser Ser Thr His Lys Val Leu Gly Cys Arg Glu 
        35                  40                  45              


Ile Phe Ser Trp Gly Leu Pro Ala Leu His Gly Phe Arg His Asn Ile 
    50                  55                  60                  


His His Gln Ser Ser Ser Ile Val Glu Glu Gln Asn Asp Pro Phe Ser 
65                  70                  75                  80  


Leu Val Ala Asp Glu Leu Ser Met Val Ala Asn Arg Leu Arg Ser Met 
                85                  90                  95      


Val Val Thr Glu Val Pro Lys Leu Ala Ser Ala Ala Glu Tyr Phe Phe 
            100                 105                 110         


Lys Met Gly Val Glu Gly Lys Arg Phe Arg Pro Thr Val Leu Leu Leu 
        115                 120                 125             


Met Ala Thr Ala Met Asn Ile Ser Ile Leu Glu Pro Ser Leu Arg Gly 
    130                 135                 140                 


Pro Gly Asp Ala Leu Thr Thr Glu Leu Arg Ala Arg Gln Gln Arg Ile 
145                 150                 155                 160 


Ala Glu Ile Thr Glu Met Ile His Val Ala Ser Leu Leu His Asp Asp 
                165                 170                 175     


Val Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile Gly Ser Leu Asn Phe 
            180                 185                 190         


Val Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp Phe Leu Leu Ser 
        195                 200                 205             


Arg Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr Glu Val Val Ser 
    210                 215                 220                 


Leu Leu Ala Lys Val Val Glu His Leu Val Thr Gly Glu Thr Met Gln 
225                 230                 235                 240 


Met Thr Thr Thr Cys Glu Gln Arg Cys Ser Met Glu Tyr Tyr Met Gln 
                245                 250                 255     


Lys Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asn Ser Cys Lys Ala 
            260                 265                 270         


Ile Ala Leu Leu Gly Gly Gln Thr Ser Glu Val Ala Met Leu Ala Tyr 
        275                 280                 285             


Glu Tyr Gly Lys Asn Leu Gly Leu Ala Tyr Gln Leu Ile Asp Asp Val 
    290                 295                 300                 


Leu Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly Lys Gly Ser Leu Ser 
305                 310                 315                 320 


Asp Ile Arg His Gly Ile Ile Thr Ala Pro Ile Leu Phe Ala Met Glu 
                325                 330                 335     


Glu Phe Pro Gln Leu Arg Glu Val Val Asp Arg Gly Phe Asp Asp Pro 
            340                 345                 350         


Ala Asn Val Asp Val Ala Leu Asp Tyr Leu Gly Lys Ser Arg Gly Ile 
        355                 360                 365             


Gln Arg Ala Arg Glu Leu Ala Lys Lys His Ala Asn Ile Ala Ala Glu 
    370                 375                 380                 


Ala Ile Asp Ser Leu Pro Glu Ser Asn Asp Glu Asp Val Arg Lys Ser 
385                 390                 395                 400 


Arg Arg Ala Leu Leu Asp Leu Thr Glu Arg Val Ile Thr Arg Thr Lys 
                405                 410                 415     


<210>  130
<211>  1251
<212>  DNA
<213>  Quercus sp.

<400>  130
atgttgttct ctcgtatttc tcgtatccgt agaccaggtt ctaatggttt cagatggttc       60

ttgtcccata agactcattt acaattcttg aaccctccag cttattccta ctcttccact      120

cataaggtct tgggttgtag agaaattttt tcctggggtt tacctgcctt acatggtttc      180

agacacaaca ttcaccacca atcttcctct attgttgaag aacaaaatga ccctttctct      240

ttggtcgctg atgagttgtc catggttgct aacagattgc gttctatggt tgttactgaa      300

gttcctaaat tagcctccgc cgctgaatac ttttttaaaa tgggtgttga aggtaagaga      360

ttcagaccaa ctgttttatt gttgatggct accgccatga acatttccat cttagaacca      420

tctttgagag gtccaggtga cgctttgacc actgaattga gagccagaca acaaagaatt      480

gctgaaatta ccgagatgat ccacgttgct tccttgttgc acgatgacgt tttggatgac      540

gctgatacta gaagaggtat tggttcctta aactttgtca tgggtaataa attagctgtt      600

ttggctggtg attttttgtt atctcgtgcc tgtgttgctt tagcttcttt gaagaacacc      660

gaagttgtct ccttgttagc caaggtcgtc gaacacttgg ttactggtga aactatgcaa      720

atgaccacta cttgtgaaca aagatgttcc atggaatact acatgcaaaa gacttactat      780

aagaccgctt ctttaatttc caactcctgt aaagccattg ctttattagg tggtcaaact      840

tctgaggtcg ctatgttagc ctacgaatat ggtaaaaact tgggtttagc ttaccaattg      900

attgatgatg tcttggattt cactggtact tctgcttcct tgggtaaggg ttccttgtct      960

gatattagac atggtatcat tactgctcca attttgtttg ctatggaaga attcccacaa     1020

ttacgtgaag ttgtcgatag aggtttcgac gatcctgcca acgtcgatgt tgccttggac     1080

tacttgggta agtctagagg tatccaaaga gccagagagt tagctaaaaa acacgctaac     1140

attgctgccg aagccatcga ctctttgcca gaatccaacg acgaggacgt cagaaagtcc     1200

cgtcgtgctt tgttggactt gaccgaaaga gtcattactc gtactaagta a              1251


<210>  131
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Pa_GPPS_Ntrunc

<400>  131

Met Tyr Thr Arg Cys Ile Leu Arg Asp Lys Tyr Ser Arg Phe Asn Leu 
1               5                   10                  15      


Arg Arg Lys Phe Phe Thr Ser Ala Lys Ser Ile Asn Ala Leu Asn Gly 
            20                  25                  30          


Leu Pro Asp Ser Gly Asn Pro Arg Gly Glu Ser Asn Gly Ile Ser Gln 
        35                  40                  45              


Phe Glu Ile Gln Gln Val Phe Arg Cys Lys Glu Tyr Ile Trp Ile Asp 
    50                  55                  60                  


Arg His Lys Phe His Asp Val Gly Phe Gln Ala His His Lys Gly Ser 
65                  70                  75                  80  


Ile Thr Asp Glu Glu Gln Val Asp Pro Phe Ser Leu Val Ala Asp Glu 
                85                  90                  95      


Leu Ser Ile Leu Ala Asn Arg Leu Arg Ser Met Ile Leu Thr Glu Ile 
            100                 105                 110         


Pro Lys Leu Gly Thr Ala Ala Glu Tyr Phe Phe Lys Leu Gly Val Glu 
        115                 120                 125             


Gly Lys Arg Phe Arg Pro Met Val Leu Leu Leu Met Ala Ser Ser Leu 
    130                 135                 140                 


Thr Ile Gly Ile Pro Glu Val Ala Ala Asp Cys Leu Arg Lys Gly Leu 
145                 150                 155                 160 


Asp Glu Glu Gln Arg Leu Arg Gln Gln Arg Ile Ala Glu Ile Thr Glu 
                165                 170                 175     


Met Ile His Val Ala Ser Leu Leu His Asp Asp Val Leu Asp Asp Ala 
            180                 185                 190         


Asp Thr Arg Arg Gly Val Gly Ser Leu Asn Phe Val Met Gly Asn Lys 
        195                 200                 205             


Leu Ala Val Leu Ala Gly Asp Phe Leu Leu Ser Arg Ala Ser Val Ala 
    210                 215                 220                 


Leu Ala Ser Leu Lys Asn Thr Glu Val Val Glu Leu Leu Ser Lys Val 
225                 230                 235                 240 


Leu Glu His Leu Val Thr Gly Glu Ile Met Gln Met Thr Asn Thr Asn 
                245                 250                 255     


Glu Gln Arg Cys Ser Met Glu Tyr Tyr Met Gln Lys Thr Phe Tyr Lys 
            260                 265                 270         


Thr Ala Ser Leu Met Ala Asn Ser Cys Lys Ala Ile Ala Leu Ile Ala 
        275                 280                 285             


Gly Gln Pro Ala Glu Val Cys Met Leu Ala Tyr Asp Tyr Gly Arg Asn 
    290                 295                 300                 


Leu Gly Leu Ala Tyr Gln Leu Leu Asp Asp Val Leu Asp Phe Thr Gly 
305                 310                 315                 320 


Thr Thr Ala Ser Leu Gly Lys Gly Ser Leu Ser Asp Ile Arg Gln Gly 
                325                 330                 335     


Ile Val Thr Ala Pro Ile Leu Phe Ala Leu Glu Glu Phe Pro Gln Leu 
            340                 345                 350         


His Asp Val Ile Asn Arg Lys Phe Lys Lys Pro Gly Asp Ile Asp Leu 
        355                 360                 365             


Ala Leu Glu Phe Leu Gly Lys Ser Asp Gly Ile Arg Lys Ala Lys Gln 
    370                 375                 380                 


Leu Ala Ala Gln His Ala Gly Leu Ala Ala Phe Ser Val Glu Ser Phe 
385                 390                 395                 400 


Pro Pro Ser Glu Ser Glu Tyr Val Lys Leu Cys Arg Lys Ala Leu Ile 
                405                 410                 415     


Asp Leu Ser Glu Lys Val Ile Thr Arg Thr Arg 
            420                 425         


<210>  132
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Pa_GPPS_N_trunc

<400>  132
atgtataccc gttgcatttt aagagacaag tattctcgtt tcaacttgag acgtaaattc       60

ttcacttccg ctaaatccat caatgccttg aatggtttac ctgactctgg taaccctaga      120

ggtgaatcta acggtatctc ccaattcgaa attcaacaag ttttccgttg taaagaatac      180

atttggatcg atcgtcacaa gttccacgat gttggttttc aagctcatca caagggttcc      240

atcactgacg aggaacaagt tgaccctttt tctttagtcg ctgatgaatt gtccatctta      300

gctaatcgtt taagatccat gatcttaacc gagattccaa agttaggtac cgctgccgaa      360

tactttttca agttgggtgt cgaaggtaag agatttagac caatggtttt gttgttgatg      420

gcctcctctt taactattgg tatccctgaa gttgccgctg attgtttgcg taagggtttg      480

gacgaagaac aaagattacg tcaacaacgt atcgctgaaa ttactgaaat gattcatgtc      540

gcctctttgt tgcacgatga tgttttggat gacgccgata ctagacgtgg tgttggttcc      600

ttgaactttg ttatgggtaa caagttggct gttttagccg gtgatttctt gttatctaga      660

gcttctgttg ccttagcttc tttaaagaac actgaggttg ttgagttatt gtctaaggtt      720

ttggagcact tagtcactgg tgagatcatg caaatgacta acactaatga acaaagatgt      780

tctatggaat attacatgca aaagactttc tacaagaccg cctctttgat ggctaattct      840

tgtaaagcca ttgccttgat cgctggtcaa cctgccgaag tctgcatgtt ggcctacgac      900

tacggtagaa acttgggttt agcttatcaa ttattggatg acgttttgga tttcactggt      960

accactgctt ctttaggtaa gggttcctta tccgacatca gacaaggtat tgttactgcc     1020

cctattttat tcgctttgga agaattccct caattacacg acgtcatcaa ccgtaagttc     1080

aaaaaaccag gtgacatcga tttggccttg gaatttttgg gtaagtctga tggtatccgt     1140

aaagccaaac aattggctgc tcaacatgct ggtttagctg ccttttctgt cgaatccttt     1200

ccaccatctg aatccgaata cgttaagtta tgtagaaagg ccttgatcga tttgtctgaa     1260

aaggtcatta ctcgtaccag ataa                                            1284


<210>  133
<211>  381
<212>  PRT
<213>  Abies grandis

<400>  133

Met Ala Tyr Ser Ala Met Ala Thr Met Gly Tyr Asn Gly Met Ala Ala 
1               5                   10                  15      


Ser Cys His Thr Leu His Pro Thr Ser Pro Leu Lys Pro Phe His Gly 
            20                  25                  30          


Ala Ser Thr Ser Leu Glu Ala Phe Asn Gly Glu His Met Gly Leu Leu 
        35                  40                  45              


Arg Gly Tyr Ser Lys Arg Lys Leu Ser Ser Tyr Lys Asn Pro Ala Ser 
    50                  55                  60                  


Arg Ser Ser Asn Ala Thr Val Ala Gln Leu Leu Asn Pro Pro Gln Lys 
65                  70                  75                  80  


Gly Lys Lys Ala Val Glu Phe Asp Phe Asn Lys Tyr Met Asp Ser Lys 
                85                  90                  95      


Ala Met Thr Val Asn Glu Ala Leu Asn Lys Ala Ile Pro Leu Arg Tyr 
            100                 105                 110         


Pro Gln Lys Ile Tyr Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly 
        115                 120                 125             


Lys Arg Val Arg Pro Val Leu Cys Ile Ala Ala Cys Glu Leu Val Gly 
    130                 135                 140                 


Gly Thr Glu Glu Leu Ala Ile Pro Thr Ala Cys Ala Ile Glu Met Ile 
145                 150                 155                 160 


His Thr Met Ser Leu Met His Asp Asp Leu Pro Cys Ile Asp Asn Asp 
                165                 170                 175     


Asp Leu Arg Arg Gly Lys Pro Thr Asn His Lys Ile Phe Gly Glu Asp 
            180                 185                 190         


Thr Ala Val Thr Ala Gly Asn Ala Leu His Ser Tyr Ala Phe Glu His 
        195                 200                 205             


Ile Ala Val Ser Thr Ser Lys Thr Val Gly Ala Asp Arg Ile Leu Arg 
    210                 215                 220                 


Met Val Ser Glu Leu Gly Arg Ala Thr Gly Ser Glu Gly Val Met Gly 
225                 230                 235                 240 


Gly Gln Met Val Asp Ile Ala Ser Glu Gly Asp Pro Ser Ile Asp Leu 
                245                 250                 255     


Gln Thr Leu Glu Trp Ile His Ile His Lys Thr Ala Met Leu Leu Glu 
            260                 265                 270         


Cys Ser Val Val Cys Gly Ala Ile Ile Gly Gly Ala Ser Glu Ile Val 
        275                 280                 285             


Ile Glu Arg Ala Arg Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln 
    290                 295                 300                 


Val Val Asp Asp Ile Leu Asp Val Thr Lys Ser Ser Asp Glu Leu Gly 
305                 310                 315                 320 


Lys Thr Ala Gly Lys Asp Leu Ile Ser Asp Lys Ala Thr Tyr Pro Lys 
                325                 330                 335     


Leu Met Gly Leu Glu Lys Ala Lys Glu Phe Ser Asp Glu Leu Leu Asn 
            340                 345                 350         


Arg Ala Lys Gly Glu Leu Ser Cys Phe Asp Pro Val Lys Ala Ala Pro 
        355                 360                 365             


Leu Leu Gly Leu Ala Asp Tyr Val Ala Phe Arg Gln Asn 
    370                 375                 380     


<210>  134
<211>  1146
<212>  DNA
<213>  Abies grandis

<400>  134
atggcttatt ctgctatggc tactatgggt tacaacggta tggctgcttc ttgtcacact       60

ttacacccaa cttctccatt gaaacctttt cacggtgctt ctacttcctt ggaagccttc      120

aatggtgaac acatgggttt gttaagaggt tattctaagc gtaagttgtc ctcttacaaa      180

aatccagctt ctcgttcctc caatgctacc gtcgctcaat tattgaaccc accacaaaag      240

ggtaagaagg ctgttgaatt tgacttcaat aagtatatgg attctaaggc tatgaccgtc      300

aacgaggctt tgaataaagc catcccattg cgttacccac aaaagatcta cgaatctatg      360

agatattctt tgttagctgg tggtaagaga gtccgtccag ttttgtgtat cgccgcttgt      420

gaattagtcg gtggtactga ggagttagct attccaaccg cctgtgccat cgaaatgatc      480

cacaccatgt ctttgatgca cgatgatttg ccatgtatcg acaacgatga cttgagacgt      540

ggtaaaccta ccaatcataa gattttcggt gaagatactg ctgttactgc cggtaacgct      600

ttacactctt acgccttcga acatattgct gtttctactt ccaagactgt tggtgctgat      660

agaattttga gaatggtttc tgaattaggt cgtgctactg gttccgaagg tgttatgggt      720

ggtcaaatgg tcgatattgc ttctgaaggt gacccttcca ttgatttgca aactttagaa      780

tggatccaca tccacaagac tgctatgtta ttagaatgtt ctgttgtctg tggtgccatc      840

atcggtggtg cttctgaaat tgttattgag agagccagac gttatgctcg ttgtgtcggt      900

ttattgtttc aagttgttga cgacatttta gatgttacca aatcttctga cgaattgggt      960

aaaactgctg gtaaagattt aatctccgat aaagccacct accctaagtt gatgggtttg     1020

gagaaggcca aagagttttc cgatgaatta ttaaacagag ctaaaggtga attgtcttgc     1080

ttcgatccag ttaaggctgc cccattgtta ggtttggctg actacgttgc cttcagacaa     1140

aactaa                                                                1146


<210>  135
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Pb_GPPS_NTrunc

<400>  135

Met Ala Ala Ile Phe Pro Ser Ile Pro Ser Asn Phe Lys Pro Pro Gln 
1               5                   10                  15      


Ile Ser Gln Thr Leu Thr Arg Arg Arg Arg Pro Asn Arg Thr Leu Cys 
            20                  25                  30          


Thr Ala Thr Ser Asp Gln Ser Tyr Leu Ser Ala Ser Ser Ala Asp Ile 
        35                  40                  45              


Tyr Ser His Leu Leu Arg Ser Leu Pro Ala Thr Ile His Pro Ser Val 
    50                  55                  60                  


Lys Ala Pro Ile His Ser Leu Leu Ser Ser Pro Ile Pro Pro Thr Ile 
65                  70                  75                  80  


Ala Pro Pro Leu Cys Leu Ala Ala Thr Glu Leu Val Gly Gly Asn Pro 
                85                  90                  95      


Asn Ser Ala Ile Asn Ala Ala Cys Ala Ile His Leu Ile His Ala Val 
            100                 105                 110         


Thr His Thr Arg Thr Ala Pro Pro Leu Ala Glu Phe Ser Pro Gly Val 
        115                 120                 125             


Leu Leu Met Thr Gly Asp Gly Leu Leu Val Leu Ala Tyr Glu Met Leu 
    130                 135                 140                 


Ala Arg Ser Pro Ala Val Asp Ala Asp Thr Ser Val Arg Val Leu Lys 
145                 150                 155                 160 


Glu Val Ala Arg Thr Ala Ala Ala Val Ala Ala Ala Tyr Glu Gly Gly 
                165                 170                 175     


Arg Glu Gly Glu Leu Ala Ala Gly Ala Ala Ala Cys Gly Val Ile Leu 
            180                 185                 190         


Gly Gly Gly Asn Glu Glu Glu Val Glu Arg Gly Arg Arg Val Gly Met 
        195                 200                 205             


Phe Ala Gly Lys Met Glu Leu Val Glu Ala Glu Val Glu Leu Arg Leu 
    210                 215                 220                 


Gly Phe Glu Asp Ala Lys Ala Gly Ala Val Arg Arg Leu Leu Glu Glu 
225                 230                 235                 240 


Met Arg Phe Thr Gln Ser Phe Val Asn Val Arg Asn Pro Phe Tyr Gly 
                245                 250                 255     


Lys 
    


<210>  136
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Pb_GPPS_NTrunc

<400>  136
atggctgcta tctttccatc cattccatcc aacttcaaac cacctcaaat ctctcaaact       60

ttgaccagac gtagaagacc aaaccgtact ttatgtactg ccacctctga ccaatcttac      120

ttgtccgctt cttctgccga catttattct catttgttaa gatctttacc agctactatt      180

catccatctg ttaaagcccc aatccattct ttattgtcct ctccaattcc tccaaccatc      240

gctccacctt tgtgtttagc tgctaccgaa ttggttggtg gtaaccctaa ctctgccatt      300

aacgccgcct gtgccattca tttgattcat gctgttactc atactagaac cgctccacca      360

ttagctgaat tttctcctgg tgttttgttg atgactggtg atggtttatt agttttggct      420

tacgagatgt tggccagatc cccagctgtt gatgccgata cttctgtccg tgttttgaag      480

gaagtcgcta gaaccgccgc cgccgtcgcc gctgcttatg aaggtggtag agaaggtgaa      540

ttagctgccg gtgccgctgc ttgtggtgtc attttgggtg gtggtaacga agaagaggtc      600

gaaagaggtc gtagagtcgg tatgttcgct ggtaaaatgg aattagttga agctgaagtc      660

gaattgagat tgggtttcga agatgctaaa gccggtgccg ttagaagatt gttggaagaa      720

atgcgtttca cccaatcttt tgtcaacgtt agaaaccctt tttatggtaa gtaa            774


<210>  137
<211>  420
<212>  PRT
<213>  Azadirachta indica

<400>  137

Met Leu Phe Ser Arg Gly Leu Ser Arg Ile Ser Arg Ile Pro Arg Asn 
1               5                   10                  15      


Ser Leu Ile Gly Cys Arg Trp Leu Val Ser Tyr Arg Pro Asp Thr Ile 
            20                  25                  30          


Leu Ser Gly Ser Ser His Ser Val Gly Asp Ser Thr Gln Lys Val Leu 
        35                  40                  45              


Gly Cys Arg Glu Ala Tyr Leu Trp Ser Leu Pro Ala Leu His Gly Ile 
    50                  55                  60                  


Arg His Gln Ile His Gln Gln Ser Ser Ser Leu Ile Glu Glu Glu Leu 
65                  70                  75                  80  


Asp Pro Phe Ser Leu Val Ala Asp Glu Leu Ser Leu Val Ala Asn Arg 
                85                  90                  95      


Leu Arg Ser Met Val Val Ala Glu Val Pro Lys Leu Ala Ser Ala Ala 
            100                 105                 110         


Glu Tyr Phe Phe Lys Met Gly Val Glu Gly Lys Arg Phe Arg Pro Thr 
        115                 120                 125             


Val Leu Leu Leu Met Ala Ser Ala Leu Asn Val Gln Val Pro Gln Pro 
    130                 135                 140                 


Leu Ser Asp Gly Val Gly Asp Ala Leu Thr Thr Glu Leu Arg Thr Arg 
145                 150                 155                 160 


Gln Gln Cys Ile Ala Glu Ile Thr Glu Met Ile His Val Ala Ser Leu 
                165                 170                 175     


Leu His Asp Asp Val Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile Gly 
            180                 185                 190         


Ser Leu Asn Phe Val Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp 
        195                 200                 205             


Phe Leu Leu Ser Arg Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr 
    210                 215                 220                 


Glu Val Val Ser Leu Leu Ala Thr Val Val Glu His Leu Val Thr Gly 
225                 230                 235                 240 


Glu Thr Met Gln Met Thr Thr Thr Ala Glu Gln Arg Arg Ser Met Asp 
                245                 250                 255     


Tyr Tyr Met Gln Lys Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asn 
            260                 265                 270         


Ser Cys Lys Ala Ile Ala Leu Leu Ala Gly Gln Thr Thr Glu Val Ala 
        275                 280                 285             


Met Leu Ala Phe Asp Tyr Gly Lys Asn Leu Gly Leu Ala Phe Gln Leu 
    290                 295                 300                 


Ile Asp Asp Val Leu Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly Lys 
305                 310                 315                 320 


Gly Ser Leu Ser Asp Ile Arg His Gly Ile Val Thr Ala Pro Ile Leu 
                325                 330                 335     


Phe Ala Met Glu Glu Phe Pro Glu Leu Arg Lys Val Val Asp Lys Gly 
            340                 345                 350         


Phe Asp Asp Pro Ser Asn Val Asp Ile Ala Leu Glu Tyr Leu Gly Lys 
        355                 360                 365             


Ser Arg Gly Ile Gln Arg Thr Arg Glu Leu Ala Gln Lys His Ala Asn 
    370                 375                 380                 


Leu Ala Thr Val Ala Leu Asp Ser Leu Pro Glu Ser Asn Asp Asp Asp 
385                 390                 395                 400 


Val Lys Lys Ser Arg Arg Ala Leu Leu Asp Leu Ala Gln Arg Val Ile 
                405                 410                 415     


Thr Arg Asn Lys 
            420 


<210>  138
<211>  1263
<212>  DNA
<213>  Azadirachta indica

<400>  138
atgttgtttt ccagaggttt atctcgtatt tccagaatcc cacgtaactc tttgatcggt       60

tgtagatggt tagtttctta ccgtcctgat accattttat ctggttcctc tcactccgtt      120

ggtgactcta ctcaaaaggt tttaggttgt cgtgaagctt acttgtggtc tttaccagcc      180

ttgcacggta ttagacacca aattcatcaa caatcctctt ctttgattga agaagaattg      240

gatccattct ctttagttgc tgatgaattg tctttagtcg ctaaccgttt gagatccatg      300

gtcgtcgctg aagtcccaaa attagcctcc gccgccgagt acttcttcaa gatgggtgtt      360

gagggtaaga gattccgtcc aactgtctta ttgttgatgg cctccgcctt aaacgttcaa      420

gtcccacaac ctttgtctga cggtgttggt gatgctttga ctaccgagtt gagaactaga      480

caacaatgca ttgctgagat tactgaaatg atccatgttg cttctttgtt gcatgacgac      540

gttttggatg atgctgacac tagacgtggt atcggttctt tgaacttcgt tatgggtaac      600

aagttggctg tcttggctgg tgatttcttg ttgtccagag cctgtgttgc tttagcttcc      660

ttgaagaata ctgaggttgt ctctttgttg gccaccgttg ttgaacactt ggtcaccggt      720

gaaactatgc aaatgactac tactgctgaa caaagacgtt ccatggatta ttacatgcaa      780

aagacttact ataagaccgc ctctttgatt tccaactctt gtaaagccat tgccttgtta      840

gctggtcaaa ctaccgaagt tgctatgttg gctttcgatt acggtaagaa tttgggttta      900

gcttttcaat tgatcgatga cgtcttggat tttactggta cctctgcttc tttaggtaaa      960

ggttccttgt ctgatattag acacggtatc gttaccgctc caattttatt cgctatggaa     1020

gaattcccag aattaagaaa ggttgttgat aagggttttg acgacccttc caacgttgac     1080

attgctttgg agtatttggg taagtctaga ggtattcaaa gaaccagaga attggctcaa     1140

aaacatgcca atttggccac cgtcgccttg gattctttac cagaatccaa cgacgacgat     1200

gttaagaagt ctcgtagagc tttattggac ttggctcaaa gagttattac tagaaacaag     1260

taa                                                                   1263


<210>  139
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Es_GPPS_NTrunc

<400>  139

Met Arg Arg Ser Gly Ser Ala Thr Ala Ala Ala Ala Ala Thr Leu Ala 
1               5                   10                  15      


Arg His Ala Asn Ala Cys Cys Arg Ala Arg Ser Pro Ala Leu Gly Leu 
            20                  25                  30          


Leu Pro Gly Ala Ala Ala Ser Ser Ser Thr His Arg Ala Ala Leu Ser 
        35                  40                  45              


Ser Asn Ser Gly His Gly Gly Asp Gly Ser Gly His Tyr Asp Ala Ala 
    50                  55                  60                  


Met Arg Arg Arg Glu Ser Cys Ala Ser Arg Ser Arg His Arg Trp Ser 
65                  70                  75                  80  


Gly Gln Glu Ala Ala Ala Ala Ser Ala Thr Thr Thr Thr Ala Arg Arg 
                85                  90                  95      


Ala Pro Gly Gly Val Ala Gly Ala Ser Gly Gln Gly Ser Ala Ala Gly 
            100                 105                 110         


Ser Val Arg Ala Leu Ser Ser Ser Phe Leu Ala Asp Ala Val Arg Glu 
        115                 120                 125             


Thr Ala Thr Asn His Cys Ile Asp Arg Val Val Asn Gly Gly Leu Asp 
    130                 135                 140                 


Gly Ser Val Pro Val Asp Lys Asp Thr Pro Thr Val Glu Val Gln Asp 
145                 150                 155                 160 


Phe Val Tyr Asp Ile Asp Phe Ala Gln Arg Pro Ser Gly Ala Ser Gln 
                165                 170                 175     


Ser Leu Ala Asp Gly Pro Asp Pro Phe Glu Leu Val Ser Ala Glu Leu 
            180                 185                 190         


Ala Gly Leu Ser Asp Gly Ile Lys Ser Leu Ile Gly Thr Glu His Ala 
        195                 200                 205             


Val Leu Asn Ala Ala Ala Lys Tyr Phe Phe Glu Leu Asp Gly Gly Lys 
    210                 215                 220                 


Lys Ile Arg Pro Thr Met Val Ile Leu Met Ser Gln Ala Cys Asn Ser 
225                 230                 235                 240 


Asn Ser Gln Gln Val Arg Pro Asp Val Gln Pro Gly Thr Glu Leu Val 
                245                 250                 255     


Asn Pro Leu Gln Leu Arg Leu Ala Glu Ile Thr Glu Met Ile His Ala 
            260                 265                 270         


Ala Ser Leu Phe His Asp Asp Val Ile Asp Glu Ala Asp Thr Arg Arg 
        275                 280                 285             


Gly Val Pro Ser Val Asn Lys Val Phe Gly Asn Lys Leu Ala Ile Leu 
    290                 295                 300                 


Ala Gly Asp Phe Leu Leu Ala Arg Ser Ser Met Ser Leu Ala Arg Leu 
305                 310                 315                 320 


Arg Ser Leu Glu Ser Val Glu Leu Met Ser Ala Ala Ile Glu His Leu 
                325                 330                 335     


Val Lys Gly Glu Val Leu Gln Met Arg Pro Thr Glu Asp Gly Gly Gly 
            340                 345                 350         


Ala Phe Glu Tyr Tyr Val Arg Lys Asn Tyr Tyr Lys Thr Gly Ser Leu 
        355                 360                 365             


Met Ala Asn Ser Cys Lys Ala Ser Ala Val Leu Gly Gln His Asp Leu 
    370                 375                 380                 


Glu Val Gln Glu Val Ala Phe Glu Tyr Gly Lys Arg Val Gly Leu Ala 
385                 390                 395                 400 


Phe Gln Leu Val Asp Asp Ile Leu Asp Phe Glu Gly Asn Thr Phe Thr 
                405                 410                 415     


Leu Gly Lys Pro Ala Leu Asn Asp Leu Arg Gln Gly Leu Ala Thr Ala 
            420                 425                 430         


Pro Val Leu Leu Ala Ala Glu Gln Gln Pro Gly Leu Ala Lys Leu Ile 
        435                 440                 445             


Ser Arg Lys Phe Arg Gly Pro Gly Asp Val Asp Glu Ala Leu Glu Leu 
    450                 455                 460                 


Val His Arg Ser Asp Gly Ile Ala Arg Ala Lys Glu Val Ala Val Val 
465                 470                 475                 480 


Gln Ala Glu Lys Ala Met Ser Ala Ile Leu Thr Leu His Asp Ser Pro 
                485                 490                 495     


Ala Gln Asn Ala Leu Val Gln Leu Ala His Lys Ile Val Asn Arg Asn 
            500                 505                 510         


His 
    


<210>  140
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Es_GPPS_NTrunc

<400>  140
atgcgtagat ccggttccgc taccgccgct gccgctgcca ccttagccag acacgccaac       60

gcctgttgta gagcccgttc cccagcttta ggtttgttgc ctggtgccgc cgcttcttcc      120

tctactcaca gagccgcctt gtcttctaat tctggtcatg gtggtgatgg ttccggtcat      180

tacgacgctg ctatgagaag aagagaatct tgcgcttcca gatctcgtca cagatggtcc      240

ggtcaagaag ctgccgccgc ctccgccact accaccaccg ctcgtcgtgc tccaggtggt      300

gtcgccggtg cttctggtca aggttctgct gccggttctg ttagagcctt atcctcttct      360

tttttagccg atgccgttcg tgaaaccgct actaaccact gtatcgaccg tgttgtcaac      420

ggtggtttgg acggttctgt cccagtcgat aaagataccc caactgtcga agttcaagac      480

tttgtttatg atattgactt tgctcaacgt ccatccggtg cctctcaatc tttagctgac      540

ggtccagatc cattcgagtt agtttccgct gagttggccg gtttgtctga tggtattaag      600

tctttgattg gtaccgaaca tgctgtcttg aacgccgccg ccaaatattt cttcgaatta      660

gatggtggta aaaagatcag acctactatg gttatcttaa tgtcccaagc ttgtaactct      720

aattcccaac aagttcgtcc tgacgttcaa ccaggtactg aattagtcaa tcctttgcaa      780

ttaagattgg ctgaaatcac cgagatgatt catgctgctt ctttattcca cgacgatgtt      840

attgatgagg ctgatactag acgtggtgtc ccttctgtta ataaagtttt cggtaacaaa      900

ttagccatct tggccggtga cttcttattg gctagatcct ctatgtcctt ggcccgttta      960

agatccttgg agtccgtcga attgatgtcc gccgctatcg aacacttggt caaaggtgaa     1020

gttttacaaa tgcgtccaac tgaggacggt ggtggtgctt tcgagtacta cgtcagaaaa     1080

aattactaca agactggttc tttgatggct aactcctgta aggcctccgc cgttttaggt     1140

caacacgact tagaagtcca agaggtcgct tttgaatacg gtaagagagt cggtttggct     1200

ttccaattgg ttgacgatat tttagatttt gaaggtaata ctttcacttt gggtaagcca     1260

gctttaaacg acttgagaca aggtttagcc actgcccctg tcttgttagc tgctgaacaa     1320

caacctggtt tagctaaatt gatctccaga aagtttagag gtcctggtga tgtcgatgaa     1380

gctttggaat tggtccacag atccgacggt attgctagag ctaaggaggt tgctgttgtc     1440

caagccgaaa aagctatgtc tgccattttg accttgcatg actccccagc tcaaaatgct     1500

ttggttcaat tggctcacaa aatcgtcaat cgtaaccatt ag                        1542


<210>  141
<211>  415
<212>  PRT
<213>  Solanum sp.

<400>  141

Met Ile Phe Ser Lys Gly Leu Ala Gln Ile Ser Arg Asn Arg Phe Ser 
1               5                   10                  15      


Arg Cys Arg Trp Leu Phe Ser Leu Arg Pro Ile Pro Gln Leu His Gln 
            20                  25                  30          


Ser Asn His Ile His Asp Pro Pro Lys Val Leu Gly Cys Arg Val Ile 
        35                  40                  45              


His Ser Trp Val Ser Asn Ala Leu Ser Gly Ile Gly Gln Gln Ile His 
    50                  55                  60                  


Gln Gln Ser Thr Ala Val Ala Glu Glu Gln Val Asp Pro Phe Ser Leu 
65                  70                  75                  80  


Val Ala Asp Glu Leu Ser Leu Leu Thr Asn Arg Leu Arg Ser Met Val 
                85                  90                  95      


Val Ala Glu Val Pro Lys Leu Ala Ser Ala Ala Glu Tyr Phe Phe Lys 
            100                 105                 110         


Leu Gly Val Glu Gly Lys Arg Phe Arg Pro Thr Val Leu Leu Leu Met 
        115                 120                 125             


Ala Thr Ala Leu Asn Val Gln Ile Pro Arg Ser Ala Pro Gln Val Asp 
    130                 135                 140                 


Val Asp Ser Phe Ser Gly Asp Leu Arg Thr Arg Gln Gln Cys Ile Ala 
145                 150                 155                 160 


Glu Ile Thr Glu Met Ile His Val Ala Ser Leu Leu His Asp Asp Val 
                165                 170                 175     


Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile Gly Ser Leu Asn Phe Val 
            180                 185                 190         


Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp Phe Leu Leu Ser Arg 
        195                 200                 205             


Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr Glu Val Val Cys Leu 
    210                 215                 220                 


Leu Ala Thr Val Val Glu His Leu Val Thr Gly Glu Thr Met Gln Met 
225                 230                 235                 240 


Thr Thr Ser Ser Asp Glu Arg Cys Ser Met Glu Tyr Tyr Met Gln Lys 
                245                 250                 255     


Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asn Ser Cys Lys Ala Ile 
            260                 265                 270         


Ala Leu Leu Ala Gly His Ser Ala Glu Val Ser Val Leu Ala Phe Asp 
        275                 280                 285             


Tyr Gly Lys Asn Leu Gly Leu Ala Phe Gln Leu Ile Asp Asp Val Leu 
    290                 295                 300                 


Asp Phe Thr Gly Thr Ser Ala Thr Leu Gly Lys Gly Ser Leu Ser Asp 
305                 310                 315                 320 


Ile Arg His Gly Ile Val Thr Ala Pro Ile Leu Tyr Ala Met Glu Glu 
                325                 330                 335     


Phe Pro Gln Leu Arg Thr Leu Val Asp Arg Gly Phe Asp Asp Pro Val 
            340                 345                 350         


Asn Val Glu Ile Ala Leu Asp Tyr Leu Gly Lys Ser Arg Gly Ile Gln 
        355                 360                 365             


Arg Thr Arg Glu Leu Ala Arg Lys His Ala Ser Leu Ala Ser Ala Ala 
    370                 375                 380                 


Ile Asp Ser Leu Pro Glu Ser Asp Asp Glu Glu Val Gln Arg Ser Arg 
385                 390                 395                 400 


Arg Ala Leu Val Glu Leu Thr His Arg Val Ile Thr Arg Thr Lys 
                405                 410                 415 


<210>  142
<211>  1248
<212>  DNA
<213>  Solanum sp.

<400>  142
atgatctttt ccaagggttt agctcaaatc tctcgtaata gattctctcg ttgcagatgg       60

ttattctctt tgcgtccaat tcctcaatta caccaatcca atcacatcca cgacccacca      120

aaagttttgg gttgtcgtgt cattcactct tgggtttcta atgccttgtc tggtatcggt      180

caacaaatcc atcaacaatc tactgccgtt gccgaggaac aagtcgaccc tttttctttg      240

gttgctgatg agttatcctt gttaaccaac agattgagat ccatggttgt cgctgaagtc      300

cctaagttag cctccgccgc tgagtatttc tttaagttag gtgtcgaagg taaacgtttc      360

cgtccaactg tcttgttgtt gatggccact gccttaaacg tccaaattcc tcgttctgct      420

ccacaagttg acgttgactc tttttctggt gacttgagaa ctagacaaca atgtatcgct      480

gaaattactg aaatgattca cgtcgcctct ttgttgcatg atgacgtctt agatgatgct      540

gatactagaa gaggtattgg ttccttaaat tttgttatgg gtaataagtt ggctgttttg      600

gctggtgatt tcttgttatc cagagcctgc gtcgccttag cctccttgaa gaacaccgaa      660

gttgtctgtt tattggccac cgttgtcgaa catttggtta ccggtgaaac tatgcaaatg      720

actacctcct ccgatgaaag atgttccatg gaatactaca tgcaaaagac ctactataag      780

actgcctctt tgatttctaa ctcttgtaaa gccattgcct tgttagccgg tcactctgct      840

gaagtttctg tcttggcctt cgattacggt aagaacttag gtttggcttt tcaattgatc      900

gacgatgttt tggacttcac cggtacctct gctactttgg gtaaaggttc cttgtccgat      960

atcagacatg gtatcgttac tgctcctatt ttgtatgcta tggaagaatt ccctcaatta     1020

cgtactttgg ttgacagagg tttcgatgat ccagttaatg ttgagatcgc tttggattac     1080

ttgggtaaat cccgtggtat tcaaagaact agagaattag ccagaaagca tgcctcttta     1140

gcctctgccg ccatcgattc cttgcctgaa tccgacgatg aggaagttca aagatctcgt     1200

agagctttgg tcgaattgac ccatagagtc attactcgta ctaagtaa                  1248


<210>  143
<211>  330
<212>  PRT
<213>  Hevea brasiliensis

<400>  143

Met Gln Phe Leu Arg Gly Leu Ser Pro Ile Ser Arg Ser Gly Leu Arg 
1               5                   10                  15      


Leu Phe Leu Ser Arg Gln Leu Tyr Pro Phe Pro Val Ala Asn Ser Ser 
            20                  25                  30          


Gln Leu Leu Gly Asp Ser Thr Gln Lys Val Phe Asn Arg Arg Glu Thr 
        35                  40                  45              


Tyr Ser Trp Ser Leu Val Asp Ser His Gly Phe Lys Gln Gln Ile His 
    50                  55                  60                  


His Gln Ser Ser Phe Leu Ser Glu Glu Pro Leu Asp Pro Phe Ser Leu 
65                  70                  75                  80  


Val Ala Asp Glu Leu Ser Leu Val Ala Asn Arg Leu Arg Ala Met Leu 
                85                  90                  95      


Val Ser Glu Val Pro Lys Leu Ala Ser Ala Ala Glu Tyr Phe Phe Lys 
            100                 105                 110         


Met Gly Val Glu Gly Lys Arg Leu Arg Pro Thr Val Leu Leu Leu Met 
        115                 120                 125             


Ala Thr Ala Leu Asn Val His Ile His Glu Pro Met Pro Asn Gly Val 
    130                 135                 140                 


Gly Asp Thr Leu Gly Ala Glu Leu Arg Thr Arg Gln Gln Cys Ile Ala 
145                 150                 155                 160 


Glu Ile Thr Glu Met Ile His Val Ala Ser Leu Leu His Asp Asp Val 
                165                 170                 175     


Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile Gly Ser Leu Asn Phe Val 
            180                 185                 190         


Met Gly Asn Lys Val Ala Val Leu Ala Gly Asp Phe Leu Leu Ser Arg 
        195                 200                 205             


Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr Glu Val Val Ser Leu 
    210                 215                 220                 


Leu Ala Thr Val Val Glu His Leu Val Thr Gly Glu Thr Met Gln Met 
225                 230                 235                 240 


Thr Ser Thr Ser Glu Gln Arg Cys Ser Met Asp His Tyr Met Gln Lys 
                245                 250                 255     


Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asp Ser Cys Lys Ala Ile 
            260                 265                 270         


Ala Leu Leu Ala Gly Gln Thr Thr Glu Val Ala Met Leu Ala Phe Glu 
        275                 280                 285             


Tyr Gly Lys Ser Leu Gly Leu Ala Phe Gln Leu Ile Asp Asp Val Leu 
    290                 295                 300                 


Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly Lys Gly Ser Leu Ser Asp 
305                 310                 315                 320 


Ile Arg His Val Ile Arg Leu Ser Leu Ile 
                325                 330 


<210>  144
<211>  993
<212>  DNA
<213>  Hevea brasiliensis

<400>  144
atgcaatttt tgagaggttt gtcccctatt tccagatccg gtttgcgttt attcttatct       60

cgtcaattat atccattccc agtcgccaac tcctcccaat tattaggtga ctctactcaa      120

aaggttttta acagacgtga gacttactct tggtctttgg tcgactctca cggttttaag      180

caacaaattc atcaccaatc ctcttttttg tctgaagaac cattggatcc attctctttg      240

gttgctgatg aattatcctt ggtcgctaac agattgcgtg ctatgttggt ttctgaagtc      300

ccaaaattag cctccgccgc tgaatatttt ttcaagatgg gtgttgaagg taagagattg      360

cgtccaaccg tcttgttatt aatggccact gctttaaacg ttcatatcca tgaacctatg      420

cctaacggtg ttggtgacac tttgggtgcc gaattgagaa ctagacaaca atgcatcgct      480

gaaatcaccg aaatgatcca tgttgcttct ttattacatg acgacgtttt agacgatgcc      540

gataccagaa gaggtattgg ttctttgaac ttcgttatgg gtaacaaggt tgctgttttg      600

gccggtgact ttttgttgtc cagagcttgt gttgccttag cttctttgaa gaataccgaa      660

gtcgtttctt tattggccac cgtcgtcgaa cacttggtta ctggtgagac tatgcaaatg      720

acctccactt ctgagcaacg ttgttccatg gatcattata tgcaaaagac ttactataag      780

accgcttcct taatctctga ttcctgtaaa gccatcgcct tgttagctgg tcaaactacc      840

gaggtcgcca tgttggcctt cgaatatggt aagtctttgg gtttagcttt tcaattaatc      900

gacgatgttt tagacttcac cggtacttct gcttccttgg gtaagggttc tttgtccgac      960

attagacacg ttattagatt atccttaatt taa                                   993


<210>  145
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant medium-chain fatty acid CoA ligase Ec_FADK_v1

<400>  145

Met His Pro Thr Gly Pro His Leu Gly Pro Asp Val Leu Phe Arg Glu 
1               5                   10                  15      


Ser Asn Met Lys Val Thr Leu Thr Phe Asn Glu Gln Arg Arg Ala Ala 
            20                  25                  30          


Tyr Arg Gln Gln Gly Leu Trp Gly Asp Ala Ser Leu Ala Asp Tyr Trp 
        35                  40                  45              


Gln Gln Thr Ala Arg Ala Met Pro Asp Lys Ile Ala Val Val Asp Asn 
    50                  55                  60                  


His Gly Ala Ser Tyr Thr Tyr Ser Ala Leu Asp His Ala Ala Ser Cys 
65                  70                  75                  80  


Leu Ala Asn Trp Met Leu Ala Lys Gly Ile Glu Ser Gly Asp Arg Ile 
                85                  90                  95      


Ala Phe Gln Leu Pro Gly Trp Cys Glu Phe Thr Val Ile Tyr Leu Ala 
            100                 105                 110         


Cys Leu Lys Ile Gly Ala Val Ser Val Pro Leu Leu Pro Ser Trp Arg 
        115                 120                 125             


Glu Ala Glu Leu Val Trp Val Leu Asn Lys Cys Gln Ala Lys Met Phe 
    130                 135                 140                 


Phe Ala Pro Thr Leu Phe Lys Gln Thr Arg Pro Val Asp Leu Ile Leu 
145                 150                 155                 160 


Pro Leu Gln Asn Gln Leu Pro Gln Leu Gln Gln Ile Val Gly Val Asp 
                165                 170                 175     


Lys Leu Ala Pro Ala Thr Ser Ser Leu Ser Leu Ser Gln Ile Ile Ala 
            180                 185                 190         


Asp Asn Thr Ser Leu Thr Thr Ala Ile Thr Thr His Gly Asp Glu Leu 
        195                 200                 205             


Ala Ala Val Leu Phe Thr Ser Gly Thr Glu Gly Leu Pro Lys Gly Val 
    210                 215                 220                 


Met Leu Thr His Asn Asn Ile Leu Ala Ser Glu Arg Ala Tyr Cys Ala 
225                 230                 235                 240 


Arg Leu Asn Leu Thr Trp Gln Asp Val Phe Met Met Pro Ala Pro Leu 
                245                 250                 255     


Gly His Ala Thr Gly Phe Leu His Gly Val Thr Ala Pro Phe Leu Ile 
            260                 265                 270         


Gly Ala Arg Ser Val Leu Leu Asp Ile Phe Thr Pro Asp Ala Cys Leu 
        275                 280                 285             


Ala Leu Leu Glu Gln Gln Arg Cys Thr Cys Met Leu Gly Ala Thr Pro 
    290                 295                 300                 


Phe Val Tyr Asp Leu Leu Asn Val Leu Glu Lys Gln Pro Ala Asp Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Phe Phe Leu Cys Gly Gly Thr Thr Ile Pro Lys Lys 
                325                 330                 335     


Val Ala Arg Glu Cys Gln Gln Arg Gly Ile Lys Leu Leu Ser Val Tyr 
            340                 345                 350         


Gly Ser Thr Glu Ser Ser Pro His Ala Val Val Asn Leu Asp Asp Pro 
        355                 360                 365             


Leu Ser Arg Phe Met His Thr Asp Gly Tyr Ala Ala Ala Gly Val Glu 
    370                 375                 380                 


Ile Lys Val Val Asp Asp Ala Arg Lys Thr Leu Pro Pro Gly Cys Glu 
385                 390                 395                 400 


Gly Glu Glu Ala Ser Arg Gly Pro Asn Val Phe Met Gly Tyr Phe Asp 
                405                 410                 415     


Glu Pro Glu Leu Thr Ala Arg Ala Leu Asp Glu Glu Gly Trp Tyr Tyr 
            420                 425                 430         


Ser Gly Asp Leu Cys Arg Met Asp Glu Ala Gly Tyr Ile Lys Ile Thr 
        435                 440                 445             


Gly Arg Lys Lys Asp Ile Ile Val Arg Gly Gly Glu Asn Ile Ser Ser 
    450                 455                 460                 


Arg Glu Val Glu Asp Ile Leu Leu Gln His Pro Lys Ile His Asp Ala 
465                 470                 475                 480 


Cys Val Val Ala Met Ser Asp Glu Arg Leu Gly Glu Arg Ser Cys Ala 
                485                 490                 495     


Tyr Val Val Leu Lys Ala Pro His His Ser Leu Ser Leu Glu Glu Val 
            500                 505                 510         


Val Ala Phe Phe Ser Arg Lys Arg Val Ala Lys Tyr Lys Tyr Pro Glu 
        515                 520                 525             


His Ile Val Val Ile Glu Lys Leu Pro Arg Thr Thr Ser Gly Lys Ile 
    530                 535                 540                 


Gln Lys Phe Leu Leu Arg Lys Asp Ile Met Arg Arg Leu Thr Gln Asp 
545                 550                 555                 560 


Val Cys Glu Glu Ile Glu 
                565     


<210>  146
<211>  1701
<212>  DNA
<213>  Escherichia coli

<400>  146
atgcatccaa ctggtccaca cttaggtcct gatgtcttat ttagagaatc taatatgaaa       60

gtcactttga cctttaatga acaaagacgt gccgcttaca gacaacaagg tttgtggggt      120

gacgcttctt tggctgacta ctggcaacaa actgctagag ctatgccaga caagatcgcc      180

gttgtcgata accacggtgc ttcttatacc tactctgctt tggatcatgc cgcttcttgt      240

ttggctaatt ggatgttggc taagggtatc gaatctggtg atcgtattgc ttttcaattg      300

ccaggttggt gtgaatttac cgttatctac ttggcttgtt tgaagattgg tgctgtttct      360

gtcccattgt tgccatcttg gagagaagcc gaattggttt gggttttgaa caaatgccaa      420

gctaagatgt tctttgctcc aaccttgttc aagcaaacta gaccagttga cttgatttta      480

cctttacaaa atcaattacc acaattgcaa caaatcgttg gtgttgacaa gttagctcca      540

gccacctcct ctttgtcctt gtcccaaatt atcgctgata atacttcttt aaccaccgct      600

atcactactc acggtgatga gttggctgct gttttgttca cttccggtac tgagggtttg      660

ccaaagggtg ttatgttgac ccacaataac attttggctt ccgaaagagc ttattgtgct      720

cgtttgaact tgacctggca agatgttttc atgatgccag ctccattggg tcatgctact      780

ggtttcttgc acggtgttac tgccccattc ttgattggtg ctagatctgt cttgttggat      840

atctttaccc cagacgcttg cttagcttta ttggaacaac aaagatgtac ctgtatgtta      900

ggtgctactc catttgttta cgatttattg aacgttttgg aaaaacaacc agctgatttg      960

tctgccttga gattcttttt gtgtggtggt actactattc caaagaaagt tgctagagaa     1020

tgccaacaaa gaggtatcaa gttgttgtcc gtctatggtt ccactgaatc ttctcctcat     1080

gctgttgtca atttagatga cccattgtct agattcatgc acaccgatgg ttacgccgct     1140

gctggtgttg agattaaggt tgtcgacgat gctagaaaga ccttacctcc aggttgtgaa     1200

ggtgaagaag cctctagagg tccaaatgtc tttatgggtt acttcgacga gccagaattg     1260

actgctagag ctttagatga ggaaggttgg tattactctg gtgatttgtg tagaatggat     1320

gaagctggtt acattaaaat cactggtaga aagaaggaca ttattgttag aggtggtgaa     1380

aatatctcct ccagagaagt tgaagatatt ttattgcaac acccaaagat tcatgatgct     1440

tgtgttgttg ctatgtccga tgagagatta ggtgaaagat cttgtgctta cgttgttttg     1500

aaggctccac atcactcttt gtctttagaa gaagtcgttg ctttcttctc tagaaagaga     1560

gtcgccaagt acaagtaccc agaacacatt gttgttatcg aaaaattgcc tagaactact     1620

tctggtaaaa ttcaaaaatt cttgttgaga aaggatatca tgagacgttt gacccaagat     1680

gtctgtgaag aaattgaata a                                               1701


<210>  147
<211>  566
<212>  PRT
<213>  Escherichia coli

<400>  147

Met His Pro Thr Gly Pro His Leu Gly Pro Asp Val Leu Phe Arg Glu 
1               5                   10                  15      


Ser Asn Met Lys Val Thr Leu Thr Phe Asn Glu Gln Arg Arg Ala Ala 
            20                  25                  30          


Tyr Arg Gln Gln Gly Leu Trp Gly Asp Ala Ser Leu Ala Asp Tyr Trp 
        35                  40                  45              


Gln Gln Thr Ala Arg Ala Met Pro Asp Lys Ile Ala Val Val Asp Asn 
    50                  55                  60                  


His Gly Ala Ser Tyr Thr Tyr Ser Ala Leu Asp His Ala Ala Ser Cys 
65                  70                  75                  80  


Leu Ala Asn Trp Met Leu Ala Lys Gly Ile Glu Ser Gly Asp Arg Ile 
                85                  90                  95      


Ala Phe Gln Leu Pro Gly Trp Cys Glu Phe Thr Val Ile Tyr Leu Ala 
            100                 105                 110         


Cys Leu Lys Ile Gly Ala Val Ser Val Pro Leu Leu Pro Ser Trp Arg 
        115                 120                 125             


Glu Ala Glu Leu Val Trp Val Leu Asn Lys Cys Gln Ala Lys Met Phe 
    130                 135                 140                 


Phe Ala Pro Thr Leu Phe Lys Gln Thr Arg Pro Val Asp Leu Ile Leu 
145                 150                 155                 160 


Pro Leu Gln Asn Gln Leu Pro Gln Leu Gln Gln Ile Val Gly Val Asp 
                165                 170                 175     


Lys Leu Ala Pro Ala Thr Ser Ser Leu Ser Leu Ser Gln Ile Ile Ala 
            180                 185                 190         


Asp Asn Thr Ser Leu Thr Thr Ala Ile Thr Thr His Gly Asp Glu Leu 
        195                 200                 205             


Ala Ala Val Leu Phe Thr Ser Gly Thr Glu Gly Leu Pro Lys Gly Val 
    210                 215                 220                 


Met Leu Thr His Asn Asn Ile Leu Ala Ser Glu Arg Ala Tyr Cys Ala 
225                 230                 235                 240 


Arg Leu Asn Leu Thr Trp Gln Asp Val Phe Met Met Pro Ala Pro Leu 
                245                 250                 255     


Gly His Ala Thr Gly Phe Leu His Gly Val Thr Ala Pro Phe Leu Ile 
            260                 265                 270         


Gly Ala Arg Ser Val Leu Leu Asp Ile Phe Thr Pro Asp Ala Cys Leu 
        275                 280                 285             


Ala Leu Leu Glu Gln Gln Arg Cys Thr Cys Met Leu Gly Ala Thr Pro 
    290                 295                 300                 


Phe Val Tyr Asp Leu Leu Asn Val Leu Glu Lys Gln Pro Ala Asp Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Phe Phe Leu Cys Gly Gly Thr Thr Ile Pro Lys Lys 
                325                 330                 335     


Val Ala Arg Glu Cys Gln Gln Arg Gly Ile Lys Leu Leu Ser Val Tyr 
            340                 345                 350         


Gly Ser Thr Glu Ser Ser Pro His Ala Val Val Asn Leu Asp Asp Pro 
        355                 360                 365             


Leu Ser Arg Phe Met His Thr Asp Gly Tyr Ala Ala Ala Gly Val Glu 
    370                 375                 380                 


Ile Lys Val Val Asp Asp Ala Arg Lys Thr Leu Pro Pro Gly Cys Glu 
385                 390                 395                 400 


Gly Glu Glu Ala Ser Arg Gly Pro Asn Val Phe Met Gly Tyr Phe Asp 
                405                 410                 415     


Glu Pro Glu Leu Thr Ala Arg Ala Leu Asp Glu Glu Gly Trp Tyr Tyr 
            420                 425                 430         


Ser Gly Asp Leu Cys Arg Met Asp Glu Ala Gly Tyr Ile Lys Ile Thr 
        435                 440                 445             


Gly Arg Lys Lys Asp Ile Ile Val Arg Gly Gly Glu Asn Ile Ser Ser 
    450                 455                 460                 


Arg Glu Val Glu Asp Ile Leu Leu Gln His Pro Lys Ile His Asp Ala 
465                 470                 475                 480 


Cys Val Val Ala Met Ser Asp Glu Arg Leu Gly Glu Arg Ser Cys Ala 
                485                 490                 495     


Tyr Val Val Leu Lys Ala Pro His His Ser Leu Ser Leu Glu Glu Val 
            500                 505                 510         


Val Ala Phe Phe Ser Arg Lys Arg Val Ala Lys Tyr Lys Tyr Pro Glu 
        515                 520                 525             


His Ile Val Val Ile Glu Lys Leu Pro Arg Thr Thr Ser Gly Lys Ile 
    530                 535                 540                 


Gln Lys Phe Leu Leu Arg Lys Asp Ile Met Arg Arg Leu Thr Gln Asp 
545                 550                 555                 560 


Val Cys Glu Glu Ile Glu 
                565     


<210>  148
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial medium-chain fatty acid CoA ligase Ec_FADK_v2 
       nucleotide sequence

<400>  148
atgcatccaa ctggtcctca cttaggtcca gatgtcttat tcagagaatc taacatgaaa       60

gtcactttaa cttttaacga acaacgtaga gctgcttata gacaacaagg tttgtggggt      120

gatgcttcct tggctgacta ctggcaacaa actgctagag ccatgccaga taaaattgcc      180

gttgttgaca atcacggtgc ttcttacact tattctgcct tagatcacgc tgcttcctgt      240

ttagctaact ggatgttagc taagggtatt gaatccggtg atagaattgc tttccaattg      300

ccaggttggt gcgaatttac tgtcatttat ttagcttgtt taaagattgg tgccgtctcc      360

gtccctttgt tgccatcctg gagagaggcc gagttggttt gggttttaaa caagtgtcaa      420

gctaaaatgt tctttgctcc taccttgttc aagcaaacca gaccagttga cttaattttg      480

ccattacaaa accaattacc acaattgcaa caaatcgtcg gtgttgataa attagctcca      540

gccacttctt ctttgtcctt atcccaaatt attgctgata acacttcttt aactactgct      600

attactactc acggtgatga attggccgct gttttgttca cttccggtac tgaaggtttg      660

cctaaaggtg tcatgttgac tcacaacaac attttggcct ctgaaagagc ttactgtgcc      720

cgtttaaatt tgacctggca agatgtcttc atgatgcctg ctccattggg tcacgctacc      780

ggtttcttac acggtgtcac tgccccattc ttgatcggtg ctcgttctgt tttattggat      840

atctttactc cagatgcttg cttggcttta ttggaacaac aaagatgtac ctgcatgtta      900

ggtgctactc ctttcgtcta tgatttattg aacgtcttag aaaaacaacc agctgattta      960

tccgctttaa gattcttttt gtgtggtggt actactatcc caaaaaaggt cgccagagaa     1020

tgtcaacaaa gaggtattaa attattgtcc gtttatggtt ccactgaatc ttcccctcat     1080

gctgttgtca atttagacga ccctttgtcc agattcatgc acactgatgg ttacgccgct     1140

gctggtgtcg aaatcaaggt tgttgatgac gctagaaaaa ctttaccacc tggttgcgaa     1200

ggtgaagagg cttccagagg tccaaacgtc tttatgggtt actttgatga accagaattg     1260

actgccagag ctttggatga ggaaggttgg tattattctg gtgatttgtg tagaatggat     1320

gaagccggtt acatcaagat caccggtaga aagaaagaca tcatcgttag aggtggtgaa     1380

aacatttctt ctagagaagt tgaagacatt ttgttgcaac acccaaagat ccacgacgct     1440

tgtgtcgtcg ccatgtctga cgaaagattg ggtgaacgtt cttgtgctta cgtcgtcttg     1500

aaagccccac accactcttt gtctttggaa gaagtcgttg cttttttctc tcgtaagcgt     1560

gttgccaagt acaagtaccc agagcacatc gttgttattg aaaaattgcc tcgtactact     1620

tccggtaaga ttcaaaagtt cttattacgt aaggacatca tgagaagatt gactcaagac     1680

gtctgcgaag aaattgaata a                                               1701


<210>  149
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated acyl activating enzyme (Cs_AAE3_Ctrunc)

<400>  149

Met Glu Lys Ser Gly Tyr Gly Arg Asp Gly Ile Tyr Arg Ser Leu Arg 
1               5                   10                  15      


Pro Pro Leu His Leu Pro Asn Asn Asn Asn Leu Ser Met Val Ser Phe 
            20                  25                  30          


Leu Phe Arg Asn Ser Ser Ser Tyr Pro Gln Lys Pro Ala Leu Ile Asp 
        35                  40                  45              


Ser Glu Thr Asn Gln Ile Leu Ser Phe Ser His Phe Lys Ser Thr Val 
    50                  55                  60                  


Ile Lys Val Ser His Gly Phe Leu Asn Leu Gly Ile Lys Lys Asn Asp 
65                  70                  75                  80  


Trp Leu Ile Tyr Ala Pro Asn Ser Ile His Phe Pro Val Cys Phe Leu 
                85                  90                  95      


Gly Ile Ile Ala Ser Gly Ala Ile Ala Thr Thr Ser Asn Pro Leu Tyr 
            100                 105                 110         


Thr Val Ser Glu Leu Ser Lys Gln Val Lys Asp Ser Asn Pro Lys Leu 
        115                 120                 125             


Ile Ile Thr Val Pro Gln Leu Leu Glu Lys Val Lys Gly Phe Asn Leu 
    130                 135                 140                 


Pro Thr Ile Leu Ile Gly Pro Asp Ser Glu Gln Glu Ser Ser Ser Asp 
145                 150                 155                 160 


Lys Val Met Thr Phe Asn Asp Leu Val Asn Leu Gly Gly Ser Ser Gly 
                165                 170                 175     


Ser Glu Phe Pro Ile Val Asp Asp Phe Lys Gln Ser Asp Thr Ala Ala 
            180                 185                 190         


Leu Leu Tyr Ser Ser Gly Thr Thr Gly Met Ser Lys Gly Trp Leu Thr 
        195                 200                 205             


His Lys Asn Phe Ile Ala Ser Ser Leu Met Val Thr Met Glu Gln Asp 
    210                 215                 220                 


Leu Val Gly Glu Met Asp Asn Val Phe Leu Cys Phe Leu Pro Met Phe 
225                 230                 235                 240 


His Val Phe Gly Leu Ala Ile Ile Thr Tyr Ala Gln Leu Gln Arg Gly 
                245                 250                 255     


Asn Thr Val Ile Ser Ala Arg Phe Asp Leu Glu Lys Met Leu Lys Asp 
            260                 265                 270         


Val Glu Lys Tyr Val Thr His Leu Trp Trp Pro Pro Val Ile Leu Ala 
        275                 280                 285             


Leu Ser Lys Asn Ser Met Val Lys Phe Asn Leu Ser Ser Ile Lys Tyr 
    290                 295                 300                 


Ile Gly Ser Gly Ala Ala Pro Leu Gly Lys Asp Leu Met Glu Glu Cys 
305                 310                 315                 320 


Ser Lys Trp Pro Tyr Gly Ile Val Ala Gln Gly Tyr Gly Met Thr Glu 
                325                 330                 335     


Thr Cys Gly Ile Val Ser Met Glu Asp Ile Arg Gly Gly Lys Arg Asn 
            340                 345                 350         


Ser Gly Ser Ala Gly Met Leu Ala Ser Gly Val Glu Ala Gln Ile Val 
        355                 360                 365             


Ser Val Asp Thr Leu Lys Pro Leu Pro Pro Asn Gln Leu Gly Glu Ile 
    370                 375                 380                 


Trp Val Lys Gly Pro Asn Met Met Gln Gly Tyr Phe Asn Asn Pro Gln 
385                 390                 395                 400 


Ala Thr Lys Leu Thr Ile Asp Lys Lys Gly Trp Val His Thr Gly Asp 
                405                 410                 415     


Leu Gly Tyr Phe Asp Glu Asp Gly His Leu Tyr Trp Asp Arg Ile Lys 
            420                 425                 430         


Glu Leu Ile Lys Tyr Lys Gly Phe Gln Val Ala Pro Ala Glu Leu Glu 
        435                 440                 445             


Gly Leu Leu Val Ser His Pro Glu Ile Leu Asp Ala Trp Ile Pro Phe 
    450                 455                 460                 


Pro Asp Ala Glu Ala Gly Glu Val Pro Val Ala Tyr Trp Arg Ser Pro 
465                 470                 475                 480 


Asn Ser Ser Leu Thr Glu Asn Asp Val Lys Lys Phe Ile Ala Gly Gln 
                485                 490                 495     


Val Ala Ser Phe Lys Arg Leu Arg Lys Val Thr Phe Ile Asn Ser Val 
            500                 505                 510         


Pro Lys Ser Ala Ser Gly Lys Ile Leu 
        515                 520     


<210>  150
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated acyl activating enzyme (Cs_AAE3_Ctrunc)

<400>  150
atggaaaaat ctggttatgg tagagacggt atctacagat ccttgcgtcc tccattacac       60

ttgccaaaca ataataactt atctatggtt tcctttttgt tccgtaactc ttcctcttac      120

ccacaaaaac ctgctttgat tgactccgaa accaatcaaa tcttgtcctt ttcccacttc      180

aaatctactg tcattaaagt ctctcacggt ttcttgaact taggtattaa gaagaacgac      240

tggttgatct acgctcctaa ttccatccac tttccagttt gtttcttggg tatcattgct      300

tctggtgcca ttgctaccac ttctaaccct ttatacactg tttctgagtt atctaagcaa      360

gttaaagatt ctaacccaaa attgattatc actgtcccac aattattaga aaaggtcaag      420

ggtttcaatt taccaaccat tttaatcggt ccagactccg aacaagagtc ttcttccgat      480

aaagttatga cttttaacga cttagttaac ttgggtggtt cttctggttc tgagttccca      540

atcgtcgatg atttcaagca atctgacacc gccgctttat tgtattcctc tggtactact      600

ggtatgtcta agggttggtt gactcacaaa aactttatcg cttcctcttt gatggttacc      660

atggaacaag acttggttgg tgaaatggat aacgtcttct tgtgtttttt accaatgttc      720

catgttttcg gtttagctat cattacttac gctcaattac aaagaggtaa cactgtcatc      780

tctgctcgtt ttgacttaga aaagatgttg aaagacgttg aaaagtacgt tactcacttg      840

tggtggcctc ctgttatttt agctttgtct aagaattcta tggttaaatt caacttgtcc      900

tctatcaagt acattggttc tggtgccgct ccattaggta aggacttgat ggaagaatgt      960

tctaaatggc cttacggtat cgtcgctcaa ggttacggta tgactgaaac ttgtggtatc     1020

gtttctatgg aagacatcag aggtggtaag cgtaactccg gttctgctgg tatgttggct     1080

tccggtgttg aagcccaaat tgtttctgtc gatactttga aacctttgcc acctaaccaa     1140

ttaggtgaaa tttgggttaa aggtcctaac atgatgcaag gttacttcaa taaccctcaa     1200

gctactaagt taactattga taagaagggt tgggttcata ctggtgattt gggttacttc     1260

gatgaagatg gtcatttgta ctgggataga atcaaagaat taattaagta taaaggtttc     1320

caagttgccc cagctgaatt ggaaggtttg ttggtttctc atcctgaaat tttagatgct     1380

tggattcctt tcccagacgc tgaagccggt gaagttccag ttgcttactg gagatcccct     1440

aactcttcct tgactgaaaa cgacgtcaag aagttcatcg ctggtcaagt tgcttccttt     1500

aagagattaa gaaaagtcac cttcatcaac tccgttccaa agtctgcttc cggtaagatt     1560

ttg                                                                   1563


<210>  151
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated cannabidiolic acid synthase Cs_CBDASt28

<400>  151

Met Ser Asn Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile 
1               5                   10                  15      


Pro Asn Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro 
            20                  25                  30          


Leu Tyr Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr 
        35                  40                  45              


Ser Asp Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val 
    50                  55                  60                  


Ser His Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln 
65                  70                  75                  80  


Ile Arg Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile 
                85                  90                  95      


Ser Gln Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile 
            100                 105                 110         


Lys Ile Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr 
        115                 120                 125             


Leu Gly Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser 
    130                 135                 140                 


Leu Ala Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly 
145                 150                 155                 160 


Gly Gly Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp 
                165                 170                 175     


Asn Ile Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp 
            180                 185                 190         


Arg Lys Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly 
        195                 200                 205             


Ala Glu Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala 
    210                 215                 220                 


Val Pro Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His 
225                 230                 235                 240 


Glu Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr 
                245                 250                 255     


Asp Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr 
            260                 265                 270         


Asp Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser 
        275                 280                 285             


Val Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser 
    290                 295                 300                 


Phe Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp 
305                 310                 315                 320 


Ile Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp 
                325                 330                 335     


Asn Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly 
            340                 345                 350         


Ala Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser 
        355                 360                 365             


Val Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala 
    370                 375                 380                 


Gly Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser 
385                 390                 395                 400 


Glu Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu 
                405                 410                 415     


Trp Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu 
            420                 425                 430         


Asn Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys 
        435                 440                 445             


Asn Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile 
    450                 455                 460                 


Asn Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly 
465                 470                 475                 480 


Glu Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr 
                485                 490                 495     


Leu Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro 
            500                 505                 510         


Leu Pro Arg His Arg His 
        515             


<210>  152
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated cannabidiolic acid synthase Cs_CBDASt28

<400>  152
atgtctaatc caagagagaa tttcttaaag tgtttttctc aatacatccc aaacaatgct       60

actaacttaa agttggttta cactcaaaat aacccattgt acatgtctgt cttgaactct      120

accattcaca atttgcgttt tacttctgac accaccccta agccattagt tattgttacc      180

ccatcccacg tctctcacat ccaaggtact attttgtgtt ctaaaaaggt tggtttgcaa      240

attagaacta gatctggtgg tcacgactcc gagggtatgt cttacatctc tcaagttcca      300

ttcgttattg tcgacttgcg taacatgcgt tccatcaaaa tcgatgttca ctcccaaact      360

gcttgggtcg aagccggtgc cactttaggt gaggtttatt actgggtcaa tgagaagaat      420

gagaatttgt ccttggctgc tggttattgt ccaaccgtct gtgctggtgg tcattttggt      480

ggtggtggtt acggtccatt aatgagaaac tatggtttgg ctgccgataa cattatcgac      540

gctcacttgg ttaatgtcca cggtaaggtc ttagatagaa aatccatggg tgaggacttg      600

ttctgggctt tgagaggtgg tggtgctgag tcctttggta tcatcgttgc ttggaaaatt      660

cgtttagttg ctgtcccaaa atctactatg ttttctgtta agaagatcat ggaaattcac      720

gagttggtta agttggttaa taagtggcaa aatattgcct acaagtatga caaagacttg      780

ttattgatga ctcacttcat cactagaaac atcaccgata accaaggtaa aaataaaact      840

gctatccata cctacttctc ctccgttttc ttgggtggtg tcgactcctt agttgatttg      900

atgaacaaat cttttcctga attaggtatc aagaagactg attgtcgtca attgtcctgg      960

attgatacca ttatctttta ctctggtgtc gtcaattacg acaccgataa tttcaataag     1020

gaaattttat tggacagatc tgccggtcaa aacggtgctt tcaagatcaa gttggactac     1080

gttaaaaaac caatcccaga atccgtcttt gtccaaattt tggagaagtt atacgaggaa     1140

gacatcggtg ctggtatgta tgccttatat ccatacggtg gtattatgga tgaaatttcc     1200

gaatctgcta tcccatttcc acatcgtgct ggtattttgt atgaattatg gtacatttgt     1260

tcctgggaaa agcaagaaga taacgagaag cacttgaatt ggatcagaaa tatctacaat     1320

ttcatgactc cttacgtttc taagaatcct cgtttggctt acttgaacta cagagatttg     1380

gacatcggta ttaatgaccc aaagaaccca aataactata ctcaagctag aatttggggt     1440

gaaaagtact tcggtaaaaa ctttgacaga ttggttaagg ttaagacttt agttgatcca     1500

aataacttct tcagaaatga acaatccatc ccaccattgc ctagacacag acactaa        1557


<210>  153
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated tetrahydrocannabinolic acid synthase Cs_THCASt28

<400>  153

Met Ser Asn Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Lys His Ile 
1               5                   10                  15      


Pro Asn Asn Val Ala Asn Pro Lys Leu Val Tyr Thr Gln His Asp Gln 
            20                  25                  30          


Leu Tyr Met Ser Ile Leu Asn Ser Thr Ile Gln Asn Leu Arg Phe Ile 
        35                  40                  45              


Ser Asp Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser Asn Asn 
    50                  55                  60                  


Ser His Ile Gln Ala Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln 
65                  70                  75                  80  


Ile Arg Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile 
                85                  90                  95      


Ser Gln Val Pro Phe Val Val Val Asp Leu Arg Asn Met His Ser Ile 
            100                 105                 110         


Lys Ile Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr 
        115                 120                 125             


Leu Gly Glu Val Tyr Tyr Trp Ile Asn Glu Lys Asn Glu Asn Leu Ser 
    130                 135                 140                 


Phe Pro Gly Gly Tyr Cys Pro Thr Val Gly Val Gly Gly His Phe Ser 
145                 150                 155                 160 


Gly Gly Gly Tyr Gly Ala Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp 
                165                 170                 175     


Asn Ile Ile Asp Ala His Leu Val Asn Val Asp Gly Lys Val Leu Asp 
            180                 185                 190         


Arg Lys Ser Met Gly Glu Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly 
        195                 200                 205             


Gly Glu Asn Phe Gly Ile Ile Ala Ala Trp Lys Ile Lys Leu Val Ala 
    210                 215                 220                 


Val Pro Ser Lys Ser Thr Ile Phe Ser Val Lys Lys Asn Met Glu Ile 
225                 230                 235                 240 


His Gly Leu Val Lys Leu Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys 
                245                 250                 255     


Tyr Asp Lys Asp Leu Val Leu Met Thr His Phe Ile Thr Lys Asn Ile 
            260                 265                 270         


Thr Asp Asn His Gly Lys Asn Lys Thr Thr Val His Gly Tyr Phe Ser 
        275                 280                 285             


Ser Ile Phe His Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys 
    290                 295                 300                 


Ser Phe Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser 
305                 310                 315                 320 


Trp Ile Asp Thr Thr Ile Phe Tyr Ser Gly Val Val Asn Phe Asn Thr 
                325                 330                 335     


Ala Asn Phe Lys Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys 
            340                 345                 350         


Thr Ala Phe Ser Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu 
        355                 360                 365             


Thr Ala Met Val Lys Ile Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly 
    370                 375                 380                 


Ala Gly Met Tyr Val Leu Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile 
385                 390                 395                 400 


Ser Glu Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Met Tyr Glu 
                405                 410                 415     


Leu Trp Tyr Thr Ala Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His 
            420                 425                 430         


Ile Asn Trp Val Arg Ser Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser 
        435                 440                 445             


Gln Asn Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly 
    450                 455                 460                 


Lys Thr Asn His Ala Ser Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp 
465                 470                 475                 480 


Gly Glu Lys Tyr Phe Gly Lys Asn Phe Asn Arg Leu Val Lys Val Lys 
                485                 490                 495     


Thr Lys Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro 
            500                 505                 510         


Pro Leu Pro Pro His His His 
        515                 


<210>  154
<211>  1560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated tetrahydrocannabinolic acid synthase Cs_THCASt28

<400>  154
atgtctaacc ctcgtgagaa cttcttgaaa tgtttctcca aacatatccc aaacaatgtc       60

gctaacccta agttagttta cactcaacat gatcaattat atatgtctat cttgaactct      120

accatccaaa acttgagatt catctccgat accaccccaa aaccattggt tattgttacc      180

ccatccaaca attctcatat tcaagctacc attttgtgct ccaaaaaggt cggtttgcaa      240

atccgtacta gatctggtgg tcacgatgct gaaggtatgt cttacatttc ccaagtccca      300

ttcgttgttg tcgatttaag aaatatgcac tctatcaaaa tcgacgttca ctctcaaact      360

gcttgggttg aagccggtgc cactttaggt gaggtttact actggattaa cgaaaagaat      420

gaaaacttat cctttccagg tggttactgt ccaactgttg gtgttggtgg tcacttctct      480

ggtggtggtt atggtgcctt gatgagaaac tacggtttag ctgctgataa tattatcgac      540

gctcacttgg ttaatgtcga cggtaaggtt ttggacagaa aatccatggg tgaagattta      600

ttctgggcca ttagaggtgg tggtggtgaa aacttcggta tcattgctgc ttggaaaatt      660

aaattggtcg ctgtcccatc caagtctact attttctccg tcaagaaaaa catggaaatt      720

catggtttgg ttaaattatt caacaagtgg caaaacattg cttacaaata cgacaaagac      780

ttagttttga tgacccactt cattactaaa aacattaccg acaaccatgg taaaaataaa      840

actactgttc acggttactt ctcttccatt tttcatggtg gtgtcgactc cttggtcgat      900

ttaatgaaca aatctttccc tgagttgggt atcaagaaga ccgactgtaa agaattctct      960

tggatcgaca ctactatttt ctactctggt gtcgttaact tcaacaccgc taatttcaag     1020

aaggaaattt tattagatag atccgctggt aaaaagaccg ctttctctat caaattagac     1080

tacgttaaaa aaccaatccc agaaaccgct atggtcaaaa tcttggaaaa attatatgaa     1140

gaagacgttg gtgccggtat gtacgtctta tatccatatg gtggtattat ggaagagatc     1200

tctgaatccg ctatcccttt tccacacaga gccggtatta tgtacgaatt atggtacact     1260

gcttcctggg agaaacaaga agataatgaa aagcacatta actgggttag atctgtttac     1320

aacttcacta ctccatacgt ctctcaaaac ccaagattag cctacttaaa ctaccgtgat     1380

ttggatttag gtaaaactaa tcacgcttcc ccaaacaact acacccaagc tagaatttgg     1440

ggtgagaagt actttggtaa gaacttcaac cgtttagtca aggtcaagac taaagttgat     1500

ccaaacaatt ttttcagaaa cgaacaatct atcccacctt taccaccaca ccaccattag     1560


<210>  155
<211>  545
<212>  PRT
<213>  Cannabis sativa

<400>  155

Met Asn Cys Ser Ala Phe Ser Phe Trp Phe Val Cys Lys Ile Ile Phe 
1               5                   10                  15      


Phe Phe Leu Ser Phe His Ile Gln Ile Ser Ile Ala Asn Pro Arg Glu 
            20                  25                  30          


Asn Phe Leu Lys Cys Phe Ser Lys His Ile Pro Asn Asn Val Ala Asn 
        35                  40                  45              


Pro Lys Leu Val Tyr Thr Gln His Asp Gln Leu Tyr Met Ser Ile Leu 
    50                  55                  60                  


Asn Ser Thr Ile Gln Asn Leu Arg Phe Ile Ser Asp Thr Thr Pro Lys 
65                  70                  75                  80  


Pro Leu Val Ile Val Thr Pro Ser Asn Asn Ser His Ile Gln Ala Thr 
                85                  90                  95      


Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg Thr Arg Ser Gly 
            100                 105                 110         


Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln Val Pro Phe Val 
        115                 120                 125             


Val Val Asp Leu Arg Asn Met His Ser Ile Lys Ile Asp Val His Ser 
    130                 135                 140                 


Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly Glu Val Tyr Tyr 
145                 150                 155                 160 


Trp Ile Asn Glu Lys Asn Glu Asn Leu Ser Phe Pro Gly Gly Tyr Cys 
                165                 170                 175     


Pro Thr Val Gly Val Gly Gly His Phe Ser Gly Gly Gly Tyr Gly Ala 
            180                 185                 190         


Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile Ile Asp Ala His 
        195                 200                 205             


Leu Val Asn Val Asp Gly Lys Val Leu Asp Arg Lys Ser Met Gly Glu 
    210                 215                 220                 


Asp Leu Phe Trp Ala Ile Arg Gly Gly Gly Gly Glu Asn Phe Gly Ile 
225                 230                 235                 240 


Ile Ala Ala Trp Lys Ile Lys Leu Val Ala Val Pro Ser Lys Ser Thr 
                245                 250                 255     


Ile Phe Ser Val Lys Lys Asn Met Glu Ile His Gly Leu Val Lys Leu 
            260                 265                 270         


Phe Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys Asp Leu Val 
        275                 280                 285             


Leu Met Thr His Phe Ile Thr Lys Asn Ile Thr Asp Asn His Gly Lys 
    290                 295                 300                 


Asn Lys Thr Thr Val His Gly Tyr Phe Ser Ser Ile Phe His Gly Gly 
305                 310                 315                 320 


Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro Glu Leu Gly 
                325                 330                 335     


Ile Lys Lys Thr Asp Cys Lys Glu Phe Ser Trp Ile Asp Thr Thr Ile 
            340                 345                 350         


Phe Tyr Ser Gly Val Val Asn Phe Asn Thr Ala Asn Phe Lys Lys Glu 
        355                 360                 365             


Ile Leu Leu Asp Arg Ser Ala Gly Lys Lys Thr Ala Phe Ser Ile Lys 
    370                 375                 380                 


Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Thr Ala Met Val Lys Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Tyr Glu Glu Asp Val Gly Ala Gly Met Tyr Val Leu 
                405                 410                 415     


Tyr Pro Tyr Gly Gly Ile Met Glu Glu Ile Ser Glu Ser Ala Ile Pro 
            420                 425                 430         


Phe Pro His Arg Ala Gly Ile Met Tyr Glu Leu Trp Tyr Thr Ala Ser 
        435                 440                 445             


Trp Glu Lys Gln Glu Asp Asn Glu Lys His Ile Asn Trp Val Arg Ser 
    450                 455                 460                 


Val Tyr Asn Phe Thr Thr Pro Tyr Val Ser Gln Asn Pro Arg Leu Ala 
465                 470                 475                 480 


Tyr Leu Asn Tyr Arg Asp Leu Asp Leu Gly Lys Thr Asn His Ala Ser 
                485                 490                 495     


Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys Tyr Phe Gly 
            500                 505                 510         


Lys Asn Phe Asn Arg Leu Val Lys Val Lys Thr Lys Val Asp Pro Asn 
        515                 520                 525             


Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro Pro His His 
    530                 535                 540                 


His 
545 


<210>  156
<211>  1638
<212>  DNA
<213>  Cannabis sativa

<400>  156
atgaattgtt ctgctttctc tttctggttc gtttgtaaga tcatcttttt cttcttatct       60

ttccatattc aaatctctat cgctaaccct cgtgagaact tcttgaaatg tttctccaaa      120

catatcccaa acaatgtcgc taaccctaag ttagtttaca ctcaacatga tcaattatat      180

atgtctatct tgaactctac catccaaaac ttgagattca tctccgatac caccccaaaa      240

ccattggtta ttgttacccc atccaacaat tctcatattc aagctaccat tttgtgctcc      300

aaaaaggtcg gtttgcaaat ccgtactaga tctggtggtc acgatgctga aggtatgtct      360

tacatttccc aagtcccatt cgttgttgtc gatttaagaa atatgcactc tatcaaaatc      420

gacgttcact ctcaaactgc ttgggttgaa gccggtgcca ctttaggtga ggtttactac      480

tggattaacg aaaagaatga aaacttatcc tttccaggtg gttactgtcc aactgttggt      540

gttggtggtc acttctctgg tggtggttat ggtgccttga tgagaaacta cggtttagct      600

gctgataata ttatcgacgc tcacttggtt aatgtcgacg gtaaggtttt ggacagaaaa      660

tccatgggtg aagatttatt ctgggccatt agaggtggtg gtggtgaaaa cttcggtatc      720

attgctgctt ggaaaattaa attggtcgct gtcccatcca agtctactat tttctccgtc      780

aagaaaaaca tggaaattca tggtttggtt aaattattca acaagtggca aaacattgct      840

tacaaatacg acaaagactt agttttgatg acccacttca ttactaaaaa cattaccgac      900

aaccatggta aaaataaaac tactgttcac ggttacttct cttccatttt tcatggtggt      960

gtcgactcct tggtcgattt aatgaacaaa tctttccctg agttgggtat caagaagacc     1020

gactgtaaag aattctcttg gatcgacact actattttct actctggtgt cgttaacttc     1080

aacaccgcta atttcaagaa ggaaatttta ttagatagat ccgctggtaa aaagaccgct     1140

ttctctatca aattagacta cgttaaaaaa ccaatcccag aaaccgctat ggtcaaaatc     1200

ttggaaaaat tatatgaaga agacgttggt gccggtatgt acgtcttata tccatatggt     1260

ggtattatgg aagagatctc tgaatccgct atcccttttc cacacagagc cggtattatg     1320

tacgaattat ggtacactgc ttcctgggag aaacaagaag ataatgaaaa gcacattaac     1380

tgggttagat ctgtttacaa cttcactact ccatacgtct ctcaaaaccc aagattagcc     1440

tacttaaact accgtgattt ggatttaggt aaaactaatc acgcttcccc aaacaactac     1500

acccaagcta gaatttgggg tgagaagtac tttggtaaga acttcaaccg tttagtcaag     1560

gtcaagacta aagttgatcc aaacaatttt ttcagaaacg aacaatctat cccaccttta     1620

ccaccacacc accattag                                                   1638


<210>  157
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Erg10p: acetoacetyl CoA thiolase nucleotide sequence

<400>  157
atgtcccaaa atgtttacat tgtttctact gctagaactc ctatcggttc cttccaaggt       60

tccttatctt ccaaaactgc cgtcgaattg ggtgccgttg ccttgaaagg tgctttagct      120

aaagttccag agttagacgc ttccaaagat ttcgatgaaa ttatcttcgg taacgtttta      180

tccgctaact tgggtcaagc tccagccaga caagttgcct tggctgccgg tttgtctaat      240

cacatcgttg cttctactgt caacaaagtt tgtgcctctg ctatgaaagc tatcatttta      300

ggtgcccaat ctattaaatg tggtaatgct gacgttgttg tcgctggtgg ttgtgagtcc      360

atgaccaacg ccccttacta catgccagcc gccagagccg gtgccaaatt cggtcaaact      420

gttttggttg acggtgttga aagagatggt ttgaacgatg cctatgacgg tttggctatg      480

ggtgttcacg ctgaaaagtg tgctagagac tgggacatta ccagagaaca acaagataat      540

ttcgctattg aatcttacca aaagtcccaa aaatctcaaa aggaaggtaa gtttgacaat      600

gaaatcgttc cagttactat caagggtttt cgtggtaagc ctgatactca agtcaccaag      660

gatgaagaac cagcccgttt acacgtcgaa aagttgagat ctgccagaac cgttttccaa      720

aaagaaaacg gtaccgttac tgctgccaat gcttctccaa tcaacgatgg tgccgctgct      780

gttattttag tctctgagaa ggttttgaag gagaaaaatt tgaagccttt agccatcatt      840

aagggttggg gtgaagctgc tcaccaacca gctgatttca cttgggcccc ttctttagct      900

gtcccaaagg ctttaaaaca cgctggtatt gaagatatca actctgttga ctacttcgaa      960

ttcaatgaag ctttctctgt cgtcggtttg gtcaatacca aaatcttgaa gttggatcct     1020

tctaaggtta acgtttacgg tggtgctgtc gccttaggtc accctttagg ttgttctggt     1080

gctagagttg ttgtcacctt gttgtccatt ttacaacaag aaggtggtaa gatcggtgtt     1140

gctgctatct gtaacggtgg tggtggtgct tcttccattg tcatcgaaaa gatctag        1197


<210>  158
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial mevalonate pyrophosphate decarboxylase (Sc_ERG19) 
       nucleotide sequence

<400>  158
atgactgtct acactgcctc cgttactgcc cctgtcaaca ttgccacctt gaagtattgg       60

ggtaaaagag atactaaatt gaacttacca actaactcct ccatttctgt cactttgtct      120

caagatgatt tgagaacctt gacttccgct gccaccgccc ctgaatttga gagagatact      180

ttgtggttaa atggtgaacc tcattctatt gacaacgaaa gaacccaaaa ctgtttacgt      240

gacttgagac aattgcgtaa ggaaatggaa tctaaagacg cttctttacc taccttgtct      300

caatggaaat tgcatatcgt ttctgaaaat aacttcccta ctgctgccgg tttggcttcc      360

tccgctgctg gttttgctgc tttagtttct gccatcgcca aattatatca attgccacaa      420

tccacttccg aaatctctag aatcgctaga aaaggttccg gttctgcttg tagatccttg      480

ttcggtggtt acgttgcttg ggaaatgggt aaagctgaag acggtcatga ttctatggcc      540

gttcaaattg ccgactcctc cgattggcct caaatgaaag cttgtgtctt ggttgtctcc      600

gatatcaaaa aggatgtctc ttctactcaa ggtatgcaat taactgttgc cacttccgaa      660

ttgttcaaag agcgtatcga acacgttgtt ccaaagagat ttgaagttat gagaaaagct      720

atcgtcgaaa aggacttcgc tacctttgcc aaggagacta tgatggattc taactccttc      780

cacgctactt gtttggattc ctttccacct attttctaca tgaatgacac ctccaaacgt      840

attatctctt ggtgtcacac cattaaccaa ttttatggtg aaactatcgt cgcttacact      900

ttcgatgccg gtccaaacgc tgtcttgtac tatttggctg aaaacgaatc caagttattt      960

gcttttatct ataagttgtt cggttccgtc cctggttggg acaagaaatt caccactgaa     1020

caattggaag ctttcaacca ccaattcgaa tcttccaatt tcactgctag agaattagat     1080

ttggaattac aaaaggatgt cgctagagtc atcttaactc aagttggttc cggtccacaa     1140

gaaactaacg aatctttgat tgatgctaaa actggtttgc ctaaagaata a              1191


<210>  159
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial isopentenyl pyrophosphate isomerase Sc_IDI1 nucleotide
       sequence

<400>  159
atgaccgctg acaacaactc catgccacat ggtgctgtct cctcctacgc taaattagtc       60

caaaaccaaa cccctgaaga cattttagaa gagttccctg aaatcattcc attgcaacaa      120

agaccaaaca ctagatcctc cgagacttct aacgatgaat ctggtgaaac ttgtttttct      180

ggtcatgatg aagaacaaat caagttgatg aacgagaatt gtattgtttt ggactgggat      240

gacaacgcta tcggtgctgg taccaaaaag gtctgtcact tgatggaaaa catcgaaaag      300

ggtttgttgc atagagcctt ttccgtcttc atcttcaacg aacaaggtga gttattattg      360

caacaaagag ccactgaaaa aatcaccttt ccagatttat ggaccaacac ctgttgctcc      420

catccattgt gtattgatga tgaattgggt ttgaaaggta agttggacga caagattaaa      480

ggtgccatca ccgccgctgt tcgtaagtta gaccatgaat tgggtatccc tgaagacgaa      540

actaagacta gaggtaaatt ccatttcttg aatcgtattc actacatggc tccttccaat      600

gaaccatggg gtgaacacga aatcgactac attttgtttt acaaaattaa tgctaaagaa      660

aatttaaccg ttaacccaaa cgtcaacgag gttagagatt tcaagtgggt ctctccaaac      720

gatttgaaga ctatgttcgc tgacccatcc tacaagttca ctccatggtt taagatcatc      780

tgtgaaaact atttgtttaa ctggtgggag caattggacg acttatctga agttgaaaat      840

gatcgtcaaa ttcaccgtat gttgtaa                                          867


<210>  160
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial phosphomevalonate kinase Sc_ERG8 nucleotide sequence

<400>  160
atgtccgagt taagagcctt ctccgctcct ggtaaagcct tattagctgg tggttactta       60

gtcttggata ctaaatatga agccttcgtc gtcggtttat ctgccagaat gcatgccgtc      120

gcccatccat acggttcctt gcaaggttct gacaagtttg aggtccgtgt caagtctaaa      180

caattcaaag atggtgaatg gttgtatcat atttctccaa aatccggttt cattccagtt      240

tctatcggtg gttctaagaa cccattcatc gaaaaagtca tcgctaacgt tttctcttac      300

ttcaagccta atatggatga ttattgcaat agaaatttat tcgttattga tatcttctcc      360

gatgacgcct atcattccca agaagactct gttaccgagc atagaggtaa cagaagatta      420

tctttccact ctcacagaat tgaagaagtt ccaaaaactg gtttaggttc ttctgctggt      480

ttagtcaccg ttttaaccac tgccttggct tctttctttg tttccgactt agaaaataac      540

gtcgacaagt atcgtgaagt catccacaac ttggcccaag ttgctcattg tcaagctcaa      600

ggtaagattg gttccggttt cgatgttgct gccgccgcct acggttccat cagatataga      660

agattccctc cagctttgat ttctaactta ccagatattg gttctgctac ttatggttcc      720

aagttggctc acttggttga cgaagaagat tggaacatta ccatcaagtc caatcacttg      780

ccatctggtt taactttgtg gatgggtgat atcaagaacg gttctgaaac tgtcaaattg      840

gtccaaaagg tcaaaaattg gtacgattcc catatgccag agtctttgaa gatctatact      900

gaattggacc acgctaactc tcgtttcatg gatggtttgt ctaagttgga cagattgcat      960

gaaactcacg acgactactc tgaccaaatt ttcgagtcct tggaaagaaa cgactgcact     1020

tgtcaaaagt atccagaaat caccgaggtt agagatgccg ttgctactat tagaagatcc     1080

ttcagaaaga ttaccaagga atctggtgct gatattgagc ctccagttca aacttctttg     1140

ttggatgatt gccaaacttt aaaaggtgtt ttaacttgtt taattcctgg tgctggtggt     1200

tacgacgcca tcgccgttat caccaaacaa gacgtcgact taagagccca aactgccaac     1260

gacaaaagat tctccaaggt tcaatggttg gacgtcactc aagctgattg gggtgttaga     1320

aaagaaaagg acccagagac ttacttggat aaatag                               1356


<210>  161
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutant farnesyl pyrophosphate synthase (Erg20mut, F96W, N127W)

<400>  161
atggcttctg agaaggagat tcgtcgtgag agattcttga atgtttttcc taaattagtc       60

gaggaattga acgcttcttt gttggcttat ggtatgccta aggaagcttg tgattggtat      120

gctcactcct tgaattataa tactccaggt ggtaaattga accgtggttt gtctgttgtt      180

gacacttacg ctattttatc taacaagacc gtcgagcaat tgggtcaaga agagtatgaa      240

aaggtcgcta ttttaggttg gtgtattgaa ttgttgcaag cttactggtt ggttgccgat      300

gacatgatgg acaagtctat tactcgtcgt ggtcaacctt gctggtataa ggtcccagag      360

gttggtgaaa ttgctatctg ggacgctttc atgttggaag ctgctatcta taaattgttg      420

aaatcccact tcagaaacga gaaatactac attgacatca ccgagttgtt ccacgaagtc      480

actttccaaa ctgagttagg tcaattaatg gacttgatca ccgctccaga agacaaagtt      540

gacttgtcca agttttcctt gaaaaagcac tctttcatcg ttactttcaa gactgcttat      600

tactctttct acttaccagt tgccttggct atgtacgtcg ccggtatcac tgacgaaaag      660

gacttgaagc aagctcgtga cgttttgatt ccattaggtg aatatttcca aatccaagat      720

gactacttag actgttttgg tacccctgaa caaatcggta agatcggtac tgatattcaa      780

gataacaagt gctcttgggt tatcaacaag gctttagagt tagcctccgc cgaacaacgt      840

aaaactttag atgaaaacta cggtaaaaaa gactctgttg ctgaggccaa gtgtaagaag      900

atttttaacg atttaaaaat cgaacaattg tatcacgaat atgaagagtc cattgctaag      960

gatttgaagg ctaaaatttc tcaagttgac gaatcccgtg gtttcaaagc tgacgttttg     1020

actgcttttt taaacaaggt ttacaagcgt tccaaataa                            1059


<210>  162
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial tetraketide synthase (TKS) nucleotide sequence

<400>  162
atgaaccatt taagagctga gggtccagct tccgtcttgg ctatcggtac tgctaatcca       60

gagaacattt tattacaaga tgagtttcca gattactatt tccgtgttac taagtccgag      120

catatgaccc aattgaaaga aaagttccgt aaaatctgtg ataaatctat gattagaaaa      180

agaaactgct ttttaaacga agaacacttg aagcaaaacc caagattagt tgaacacgag      240

atgcaaacct tggacgctag acaagatatg ttggttgtcg aggttcctaa attgggtaaa      300

gacgcctgtg ctaaagctat caaagagtgg ggtcaaccta agtccaagat cactcactta      360

atcttcactt ccgcttccac cactgacatg cctggtgctg attaccactg tgccaagttg      420

ttgggtttgt ctccttctgt caagagagtt atgatgtacc aattaggttg ttacggtggt      480

ggtactgtct taagaattgc taaggacatc gctgaaaaca acaaaggtgc tagagtttta      540

gccgtttgtt gtgacatcat ggcttgttta tttcgtggtc catctgaatc tgacttggag      600

ttgttggttg gtcaagctat ttttggtgat ggtgccgctg ccgtcatcgt tggtgctgag      660

ccagatgaat ccgttggtga aagaccaatt ttcgaattag tctctactgg tcaaactatt      720

ttgccaaact ccgagggtac tatcggtggt catattcgtg aagccggttt aatctttgat      780

ttgcacaaag acgttccaat gttgatctct aacaacatcg aaaagtgttt aattgaggct      840

tttactccaa ttggtatctc tgactggaac tctatcttct ggatcactca tccaggtggt      900

aaggctatct tggacaaggt tgaagaaaaa ttacatttaa agtccgataa attcgtcgat      960

tctcgtcatg ttttgtctga acacggtaac atgtcttcct ccactgtctt gtttgttatg     1020

gatgaattac gtaagagatc tttggaggag ggtaagtcta ctactggtga tggtttcgaa     1080

tggggtgttt tgttcggttt cggtcctggt ttgactgttg aacgtgttgt tgttagatct     1140

gttccaatta agtactag                                                   1158


<210>  163
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial olivetolic acid cyclase (OAC) nucleotide sequence

<400>  163
atggccgtca aacacttgat cgtcttaaaa ttcaaggatg aaattactga agctcaaaaa       60

gaagagttct tcaaaaccta tgtcaattta gtcaacatta ttcctgctat gaaggacgtt      120

tactggggta aggatgtcac ccaaaagaac aaggaagaag gttacactca cattgttgaa      180

gtcactttcg aatctgttga aactatccaa gattatatta tccacccagc tcatgtcggt      240

tttggtgatg tttacagatc tttttgggaa aaattgttga tctttgacta tactccaaga      300

aaataa                                                                 306


<210>  164
<211>  2163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial acyl-activating enzyme Cs_AAE1_v1 nucleotide sequence

<400>  164
atgggtaaga attacaagtc cttagactct gttgttgctt ctgactttat tgctttaggt       60

attacttccg aagttgctga aaccttacac ggtagattgg ctgaaattgt ttgcaactac      120

ggtgctgcta cccctcaaac ttggattaac attgctaatc atattttgtc tccagatttg      180

ccattttctt tacaccaaat gttgttctac ggttgttaca aggatttcgg tcctgctcct      240

ccagcttgga ttcctgatcc agaaaaagtc aaatctacta acttgggtgc tttgttggaa      300

aagagaggta aggagttttt gggtgttaag tacaaggacc caatttcttc tttctctcac      360

ttccaagaat tctctgttag aaaccctgaa gtttactgga gaactgtttt gatggatgag      420

atgaagattt ctttttctaa ggacccagag tgtatcttaa gaagagacga cattaacaat      480

ccaggtggtt ctgagtggtt accaggtggt tacttgaact ctgccaaaaa ttgcttgaac      540

gttaactcta acaagaaatt gaatgacact atgattgtct ggagagatga gggtaacgat      600

gatttgcctt tgaataaatt gactttggat caattgagaa aaagagtctg gttggttggt      660

tacgctttgg aagaaatggg tttagaaaaa ggttgtgcta tcgccatcga tatgcctatg      720

cacgttgatg ctgttgttat ttatttggct attgttttag ctggttatgt tgttgtttcc      780

atcgccgact ccttctctgc tccagaaatc tccaccagat tgagattgtc taaagccaaa      840

gccattttca cccaagacca catcattaga ggtaagaagc gtattccatt gtattctcgt      900

gttgttgaag ctaaatctcc tatggctatc gtcatcccat gctctggttc taacatcggt      960

gctgaattaa gagacggtga tatttcttgg gactactttt tagaaagagc taaagaattc     1020

aaaaactgcg agtttactgc tagagaacaa cctgtcgacg cttatactaa tattttattc     1080

tcttctggta ctactggtga acctaaggct attccatgga cccaagctac tcctttgaaa     1140

gccgctgctg atggttggtc ccatttagac atcagaaaag gtgatgtcat cgtctggcca     1200

actaacttag gttggatgat gggtccatgg ttagtctacg cttctttgtt gaatggtgcc     1260

tctatcgcct tatataatgg ttccccttta gtctctggtt ttgctaaatt cgttcaagat     1320

gctaaggtta ccatgttagg tgttgtccct tctatcgtta gatcttggaa atctactaac     1380

tgtgtttctg gttacgactg gtccactatt cgttgtttct cttcttctgg tgaagcttcc     1440

aatgtcgatg agtacttatg gttaatgggt cgtgctaact acaagccagt catcgaaatg     1500

tgcggtggta ctgaaattgg tggtgctttt tccgctggtt cttttttaca agcccaatcc     1560

ttgtcttcct tctcctctca atgtatgggt tgtactttat atatcttaga taagaatggt     1620

taccctatgc ctaaaaacaa gccaggtatt ggtgaattag ctttgggtcc tgttatgttt     1680

ggtgcttcta aaaccttgtt aaatggtaat catcacgacg tttacttcaa aggtatgcct     1740

actttgaacg gtgaggtttt gagacgtcat ggtgatattt tcgaattaac ttccaacggt     1800

tattatcacg ctcacggtag agctgatgat actatgaaca ttggtggtat taagatctct     1860

tccatcgaaa ttgagagagt ttgtaacgag gttgacgatc gtgttttcga aactactgct     1920

attggtgtcc ctcctttagg tggtggtcca gaacaattgg ttatcttttt cgtcttgaag     1980

gactccaacg acaccactat cgacttaaac caattaagat tgtctttcaa cttgggtttg     2040

caaaagaagt tgaatccatt atttaaggtt actcgtgtcg ttccattgtc ctccttgcca     2100

agaactgcta ccaacaagat tatgcgtaga gtcttgagac aacaattctc tcactttgag     2160

taa                                                                   2163


<210>  165
<211>  2163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial acyl-activating enzyme Cs_AAE1_v2 nucleotide sequence

<400>  165
atgggtaaga actacaaatc cttagattcc gtcgtcgctt ctgatttcat cgctttgggt       60

attacttctg aagttgctga aaccttgcat ggtagattgg ctgaaattgt ctgtaactac      120

ggtgctgcta ccccacaaac ttggatcaac attgctaacc acatcttatc ccctgacttg      180

ccattctcct tacaccaaat gttgttctac ggttgttata aagatttcgg tccagctcct      240

cctgcttgga ttcctgaccc agagaaggtt aagtctacta atttaggtgc tttgttagag      300

aagagaggta aggaattttt aggtgttaag tataaagatc caatttcttc cttctctcac      360

ttccaagaat tttctgttag aaacccagaa gtttactgga gaactgtttt gatggatgaa      420

atgaagatct ctttttccaa ggacccagag tgtattttga gacgtgatga catcaacaat      480

ccaggtggtt ctgagtggtt accaggtggt tacttgaact ctgccaagaa ttgtttgaac      540

gttaactcta acaaaaagtt gaacgatacc atgattgttt ggagagacga aggtaacgat      600

gatttgccat tgaataagtt aaccttggat caattgagaa aaagagtctg gttagtcggt      660

tacgctttgg aagagatggg tttggaaaag ggttgtgcta tcgccatcga tatgccaatg      720

catgttgatg ctgttgttat ctatttggcc attgttttgg ctggttacgt tgttgtttcc      780

atcgctgact ccttctctgc tccagaaatt tctactagat taagattgtc taaagccaaa      840

gccattttca ctcaagacca tattattaga ggtaagaaaa gaattccatt gtattccaga      900

gttgttgaag ctaaatcccc aatggccatc gtcatcccat gctctggttc taatattggt      960

gccgaattga gagacggtga tatctcttgg gactactttt tggagcgtgc taaagaattt     1020

aaaaactgcg aattcaccgc cagagaacaa ccagttgacg cctacactaa cattttgttt     1080

tcttctggta ctactggtga acctaaggct attccatgga ctcaagctac tccattgaaa     1140

gccgccgccg atggttggtc ccacttagat attagaaagg gtgatgtcat cgtctggcct     1200

actaacttgg gttggatgat gggtccttgg ttggtttacg cttccttatt gaacggtgcc     1260

tctatcgctt tatataatgg ttccccttta gtttctggtt ttgctaaatt cgttcaagat     1320

gctaaggtta ctatgttggg tgtcgtccca tccattgtcc gttcctggaa gtctaccaat     1380

tgtgtttctg gttatgattg gtctactatt cgttgttttt cttcctctgg tgaagcttct     1440

aatgtcgatg aatatttgtg gttaatgggt agagctaact acaagccagt tattgaaatg     1500

tgtggtggta ctgaaattgg tggtgctttc tctgctggtt cctttttgca agctcaatcc     1560

ttgtcttctt tctcctccca atgtatgggt tgcactttat acatcttgga caagaatggt     1620

taccctatgc caaagaataa accaggtatt ggtgaattgg ctttgggtcc agtcatgttc     1680

ggtgcttcta agactttgtt gaacggtaac catcatgacg tctacttcaa gggtatgcct     1740

accttgaacg gtgaagtttt aagacgtcac ggtgacattt tcgaattgac ttccaacggt     1800

tattatcatg ctcacggtag agctgacgac actatgaaca tcggtggtat taagatctct     1860

tctatcgaaa ttgaaagagt ttgcaacgag gttgatgatc gtgtcttcga aaccactgct     1920

attggtgtcc ctcctttagg tggtggtcct gagcaattgg ttattttctt tgtcttaaag     1980

gattctaacg acaccactat tgacttaaat caattgagat tgtccttcaa tttgggtttg     2040

caaaagaagt tgaacccatt attcaaggtt actcgtgtcg ttcctttgtc ctctttgcca     2100

agaaccgcta ccaataaaat tatgagacgt gttttgcgtc aacaattctc tcactttgaa     2160

taa                                                                   2163


<210>  166
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial acyl-activating enzyme Cs_AAE3 nucleotide sequence

<400>  166
atggaaaaat ctggttatgg tagagacggt atctacagat ccttgcgtcc tccattacac       60

ttgccaaaca ataataactt atctatggtt tcctttttgt tccgtaactc ttcctcttac      120

ccacaaaaac ctgctttgat tgactccgaa accaatcaaa tcttgtcctt ttcccacttc      180

aaatctactg tcattaaagt ctctcacggt ttcttgaact taggtattaa gaagaacgac      240

tggttgatct acgctcctaa ttccatccac tttccagttt gtttcttggg tatcattgct      300

tctggtgcca ttgctaccac ttctaaccct ttatacactg tttctgagtt atctaagcaa      360

gttaaagatt ctaacccaaa attgattatc actgtcccac aattattaga aaaggtcaag      420

ggtttcaatt taccaaccat tttaatcggt ccagactccg aacaagagtc ttcttccgat      480

aaagttatga cttttaacga cttagttaac ttgggtggtt cttctggttc tgagttccca      540

atcgtcgatg atttcaagca atctgacacc gccgctttat tgtattcctc tggtactact      600

ggtatgtcta agggttggtt gactcacaaa aactttatcg cttcctcttt gatggttacc      660

atggaacaag acttggttgg tgaaatggat aacgtcttct tgtgtttttt accaatgttc      720

catgttttcg gtttagctat cattacttac gctcaattac aaagaggtaa cactgtcatc      780

tctgctcgtt ttgacttaga aaagatgttg aaagacgttg aaaagtacgt tactcacttg      840

tggtggcctc ctgttatttt agctttgtct aagaattcta tggttaaatt caacttgtcc      900

tctatcaagt acattggttc tggtgccgct ccattaggta aggacttgat ggaagaatgt      960

tctaaatggc cttacggtat cgtcgctcaa ggttacggta tgactgaaac ttgtggtatc     1020

gtttctatgg aagacatcag aggtggtaag cgtaactccg gttctgctgg tatgttggct     1080

tccggtgttg aagcccaaat tgtttctgtc gatactttga aacctttgcc acctaaccaa     1140

ttaggtgaaa tttgggttaa aggtcctaac atgatgcaag gttacttcaa taaccctcaa     1200

gctactaagt taactattga taagaagggt tgggttcata ctggtgattt gggttacttc     1260

gatgaagatg gtcatttgta ctgggataga atcaaagaat taattaagta taaaggtttc     1320

caagttgccc cagctgaatt ggaaggtttg ttggtttctc atcctgaaat tttagatgct     1380

tggattcctt tcccagacgc tgaagccggt gaagttccag ttgcttactg gagatcccct     1440

aactcttcct tgactgaaaa cgacgtcaag aagttcatcg ctggtcaagt tgcttccttt     1500

aagagattaa gaaaagtcac cttcatcaac tccgttccaa agtctgcttc cggtaagatt     1560

ttgagaagag aattaatcca aaaggttcgt tccaacatgt ag                        1602


<210>  167
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial cannabidiolic acid synthase (CBDAS) nucleotide 
       sequence

<400>  167
atgaaatgtt ccaccttttc tttctggttt gtttgtaaga tcatcttctt cttcttctcc       60

ttcaacatcc aaacttccat cgctaatcca agagagaatt tcttaaagtg tttttctcaa      120

tacatcccaa acaatgctac taacttaaag ttggtttaca ctcaaaataa cccattgtac      180

atgtctgtct tgaactctac cattcacaat ttgcgtttta cttctgacac cacccctaag      240

ccattagtta ttgttacccc atcccacgtc tctcacatcc aaggtactat tttgtgttct      300

aaaaaggttg gtttgcaaat tagaactaga tctggtggtc acgactccga gggtatgtct      360

tacatctctc aagttccatt cgttattgtc gacttgcgta acatgcgttc catcaaaatc      420

gatgttcact cccaaactgc ttgggtcgaa gccggtgcca ctttaggtga ggtttattac      480

tgggtcaatg agaagaatga gaatttgtcc ttggctgctg gttattgtcc aaccgtctgt      540

gctggtggtc attttggtgg tggtggttac ggtccattaa tgagaaacta tggtttggct      600

gccgataaca ttatcgacgc tcacttggtt aatgtccacg gtaaggtctt agatagaaaa      660

tccatgggtg aggacttgtt ctgggctttg agaggtggtg gtgctgagtc ctttggtatc      720

atcgttgctt ggaaaattcg tttagttgct gtcccaaaat ctactatgtt ttctgttaag      780

aagatcatgg aaattcacga gttggttaag ttggttaata agtggcaaaa tattgcctac      840

aagtatgaca aagacttgtt attgatgact cacttcatca ctagaaacat caccgataac      900

caaggtaaaa ataaaactgc tatccatacc tacttctcct ccgttttctt gggtggtgtc      960

gactccttag ttgatttgat gaacaaatct tttcctgaat taggtatcaa gaagactgat     1020

tgtcgtcaat tgtcctggat tgataccatt atcttttact ctggtgtcgt caattacgac     1080

accgataatt tcaataagga aattttattg gacagatctg ccggtcaaaa cggtgctttc     1140

aagatcaagt tggactacgt taaaaaacca atcccagaat ccgtctttgt ccaaattttg     1200

gagaagttat acgaggaaga catcggtgct ggtatgtatg ccttatatcc atacggtggt     1260

attatggatg aaatttccga atctgctatc ccatttccac atcgtgctgg tattttgtat     1320

gaattatggt acatttgttc ctgggaaaag caagaagata acgagaagca cttgaattgg     1380

atcagaaata tctacaattt catgactcct tacgtttcta agaatcctcg tttggcttac     1440

ttgaactaca gagatttgga catcggtatt aatgacccaa agaacccaaa taactatact     1500

caagctagaa tttggggtga aaagtacttc ggtaaaaact ttgacagatt ggttaaggtt     1560

aagactttag ttgatccaaa taacttcttc agaaatgaac aatccatccc accattgcct     1620

agacacagac actaa                                                      1635


<210>  168
<211>  2235
<212>  DNA
<213>  Saccharomyces sp.

<400>  168
atggccgctc cagattatgc acttaccgat ttaattgaat cggatcctcg tttcgaaagt       60

ttgaagacaa gattagccgg ttacaccaaa ggctctgatg aatatattga agagctatac      120

tctcaattac cactgaccag ctaccccagg tacaaaacat ttttaaagaa acaggcggtt      180

gccatttcga atccggataa tgaagctggt tttagctcga tttataggag ttctctttct      240

tctgaaaatc tagtgagctg tgtggataaa aacttaagaa ctgcatacga tcacttcatg      300

ttttctgcaa ggagatggcc tcaacgtgac tgtttaggtt caaggccaat tgataaagcc      360

acaggcacct gggaggaaac attccgtttc gagtcgtact ccacggtatc taaaagatgt      420

cataatatcg gaagtggtat attgtctttg gtaaacacga aaaggaaacg tcctttggaa      480

gccaatgatt ttgttgttgc tatcttatca cacaacaacc ctgaatggat cctaacagat      540

ttggcctgtc aggcctattc tctaactaac acggctttgt acgaaacatt aggtccaaac      600

acctccgagt acatattgaa tttaaccgag gcccccattc tgatttttgc aaaatcaaat      660

atgtatcatg tattgaagat ggtgcctgat atgaaatttg ttaatacttt ggtttgtatg      720

gatgaattaa ctcatgacga gctccgtatg ctaaatgaat cgttgctacc cgttaagtgc      780

aactctctca atgaaaaaat cacatttttt tcattggagc aggtagaaca agttggttgc      840

tttaacaaaa ttcctgcaat tccacctacc ccagattcct tgtatactat ttcgtttact      900

tctggtacta caggtttacc taaaggtgtg gaaatgtctc acagaaacat tgcgtctggg      960

atagcatttg ctttttctac cttcagaata ccgccagata aaagaaacca acagttatat     1020

gatatgtgtt ttttgccatt ggctcatatt tttgaaagaa tggttattgc gtatgatcta     1080

gccatcgggt ttggaatagg cttcttacat aaaccagacc caactgtatt ggtagaggat     1140

ttgaagattt tgaaacctta cgcggttgcc ctggttccta gaatattaac acggtttgaa     1200

gccggtataa aaaatgcttt ggataaatcg actgtccaga ggaacgtagc aaatactata     1260

ttggattcta aatcggccag atttaccgca agaggtggtc cagataaatc gattatgaat     1320

tttctagttt atcatcgcgt attgattgat aaaatcagag actctttagg tttgtccaat     1380

aactcgttta taattaccgg atcagctccc atatctaaag ataccttact atttttaaga     1440

agcgccttgg atattggtat aagacagggc tacggcttaa ctgaaacttt tgctggtgtc     1500

tgtttaagcg aaccgtttga aaaagatgtc ggatcttgtg gtgccatagg tatttctgca     1560

gaatgtagat tgaagtctgt tccagaaatg ggttaccatg ccgacaagga tttaaaaggt     1620

gaactgcaaa ttcgtggccc acaggttttt gaaagatatt ttaaaaatcc gaatgaaact     1680

tcaaaagccg ttgaccaaga tggttggttt tccacgggag atgttgcatt tatcgatgca     1740

aaaggtcgca tcagcgtcat tgatcgagtc aagaactttt tcaagctagc acatggtgaa     1800

tatattgctc cagagaaaat cgaaaatatt tatttatcat catgccccta tatcacgcaa     1860

atatttgtct ttggagatcc tttgaagaca tttttagttg gcatcgttgg tgttgatgtt     1920

gatgcagcgc aaccgatttt agctgcaaag cacccagagg tgaaaacgtg gactaaggaa     1980

gtgctagtag aaaacttaaa tcgtaataaa aagctaagga aggaattttt aaacaaaatt     2040

aataaatgca tcgatgggct acaaggattt gaaaaattgc acaacatcaa agtcggactt     2100

gagcctttga ctctcgagga tgatgttgtg acgccaactt ttaaaataaa gcgtgccaaa     2160

gcatcaaaat tcttcaaaga tacattagac caactatacg ccgaaggttc actagtcaag     2220

acagaaaagc tttag                                                      2235


<210>  169
<211>  744
<212>  PRT
<213>  Saccharomyces sp.

<400>  169

Met Ala Ala Pro Asp Tyr Ala Leu Thr Asp Leu Ile Glu Ser Asp Pro 
1               5                   10                  15      


Arg Phe Glu Ser Leu Lys Thr Arg Leu Ala Gly Tyr Thr Lys Gly Ser 
            20                  25                  30          


Asp Glu Tyr Ile Glu Glu Leu Tyr Ser Gln Leu Pro Leu Thr Ser Tyr 
        35                  40                  45              


Pro Arg Tyr Lys Thr Phe Leu Lys Lys Gln Ala Val Ala Ile Ser Asn 
    50                  55                  60                  


Pro Asp Asn Glu Ala Gly Phe Ser Ser Ile Tyr Arg Ser Ser Leu Ser 
65                  70                  75                  80  


Ser Glu Asn Leu Val Ser Cys Val Asp Lys Asn Leu Arg Thr Ala Tyr 
                85                  90                  95      


Asp His Phe Met Phe Ser Ala Arg Arg Trp Pro Gln Arg Asp Cys Leu 
            100                 105                 110         


Gly Ser Arg Pro Ile Asp Lys Ala Thr Gly Thr Trp Glu Glu Thr Phe 
        115                 120                 125             


Arg Phe Glu Ser Tyr Ser Thr Val Ser Lys Arg Cys His Asn Ile Gly 
    130                 135                 140                 


Ser Gly Ile Leu Ser Leu Val Asn Thr Lys Arg Lys Arg Pro Leu Glu 
145                 150                 155                 160 


Ala Asn Asp Phe Val Val Ala Ile Leu Ser His Asn Asn Pro Glu Trp 
                165                 170                 175     


Ile Leu Thr Asp Leu Ala Cys Gln Ala Tyr Ser Leu Thr Asn Thr Ala 
            180                 185                 190         


Leu Tyr Glu Thr Leu Gly Pro Asn Thr Ser Glu Tyr Ile Leu Asn Leu 
        195                 200                 205             


Thr Glu Ala Pro Ile Leu Ile Phe Ala Lys Ser Asn Met Tyr His Val 
    210                 215                 220                 


Leu Lys Met Val Pro Asp Met Lys Phe Val Asn Thr Leu Val Cys Met 
225                 230                 235                 240 


Asp Glu Leu Thr His Asp Glu Leu Arg Met Leu Asn Glu Ser Leu Leu 
                245                 250                 255     


Pro Val Lys Cys Asn Ser Leu Asn Glu Lys Ile Thr Phe Phe Ser Leu 
            260                 265                 270         


Glu Gln Val Glu Gln Val Gly Cys Phe Asn Lys Ile Pro Ala Ile Pro 
        275                 280                 285             


Pro Thr Pro Asp Ser Leu Tyr Thr Ile Ser Phe Thr Ser Gly Thr Thr 
    290                 295                 300                 


Gly Leu Pro Lys Gly Val Glu Met Ser His Arg Asn Ile Ala Ser Gly 
305                 310                 315                 320 


Ile Ala Phe Ala Phe Ser Thr Phe Arg Ile Pro Pro Asp Lys Arg Asn 
                325                 330                 335     


Gln Gln Leu Tyr Asp Met Cys Phe Leu Pro Leu Ala His Ile Phe Glu 
            340                 345                 350         


Arg Met Val Ile Ala Tyr Asp Leu Ala Ile Gly Phe Gly Ile Gly Phe 
        355                 360                 365             


Leu His Lys Pro Asp Pro Thr Val Leu Val Glu Asp Leu Lys Ile Leu 
    370                 375                 380                 


Lys Pro Tyr Ala Val Ala Leu Val Pro Arg Ile Leu Thr Arg Phe Glu 
385                 390                 395                 400 


Ala Gly Ile Lys Asn Ala Leu Asp Lys Ser Thr Val Gln Arg Asn Val 
                405                 410                 415     


Ala Asn Thr Ile Leu Asp Ser Lys Ser Ala Arg Phe Thr Ala Arg Gly 
            420                 425                 430         


Gly Pro Asp Lys Ser Ile Met Asn Phe Leu Val Tyr His Arg Val Leu 
        435                 440                 445             


Ile Asp Lys Ile Arg Asp Ser Leu Gly Leu Ser Asn Asn Ser Phe Ile 
    450                 455                 460                 


Ile Thr Gly Ser Ala Pro Ile Ser Lys Asp Thr Leu Leu Phe Leu Arg 
465                 470                 475                 480 


Ser Ala Leu Asp Ile Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr 
                485                 490                 495     


Phe Ala Gly Val Cys Leu Ser Glu Pro Phe Glu Lys Asp Val Gly Ser 
            500                 505                 510         


Cys Gly Ala Ile Gly Ile Ser Ala Glu Cys Arg Leu Lys Ser Val Pro 
        515                 520                 525             


Glu Met Gly Tyr His Ala Asp Lys Asp Leu Lys Gly Glu Leu Gln Ile 
    530                 535                 540                 


Arg Gly Pro Gln Val Phe Glu Arg Tyr Phe Lys Asn Pro Asn Glu Thr 
545                 550                 555                 560 


Ser Lys Ala Val Asp Gln Asp Gly Trp Phe Ser Thr Gly Asp Val Ala 
                565                 570                 575     


Phe Ile Asp Ala Lys Gly Arg Ile Ser Val Ile Asp Arg Val Lys Asn 
            580                 585                 590         


Phe Phe Lys Leu Ala His Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu 
        595                 600                 605             


Asn Ile Tyr Leu Ser Ser Cys Pro Tyr Ile Thr Gln Ile Phe Val Phe 
    610                 615                 620                 


Gly Asp Pro Leu Lys Thr Phe Leu Val Gly Ile Val Gly Val Asp Val 
625                 630                 635                 640 


Asp Ala Ala Gln Pro Ile Leu Ala Ala Lys His Pro Glu Val Lys Thr 
                645                 650                 655     


Trp Thr Lys Glu Val Leu Val Glu Asn Leu Asn Arg Asn Lys Lys Leu 
            660                 665                 670         


Arg Lys Glu Phe Leu Asn Lys Ile Asn Lys Cys Ile Asp Gly Leu Gln 
        675                 680                 685             


Gly Phe Glu Lys Leu His Asn Ile Lys Val Gly Leu Glu Pro Leu Thr 
    690                 695                 700                 


Leu Glu Asp Asp Val Val Thr Pro Thr Phe Lys Ile Lys Arg Ala Lys 
705                 710                 715                 720 


Ala Ser Lys Phe Phe Lys Asp Thr Leu Asp Gln Leu Tyr Ala Glu Gly 
                725                 730                 735     


Ser Leu Val Lys Thr Glu Lys Leu 
            740                 


<210>  170
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBPtag

<400>  170
atgaaaatcg aagagggtaa attggtcatc tggatcaatg gtgacaaagg ttacaacggt       60

ttggctgaag tcggtaaaaa attcgagaaa gacactggta ttaaggttac cgtcgaacac      120

ccagataagt tggaagaaaa atttccacaa gttgccgcta ctggtgatgg tccagacatc      180

attttctggg cccacgacag atttggtggt tatgctcaat ctggtttgtt agccgagatc      240

accccagaca aagcctttca agataaatta tacccattta cctgggatgc tgtccgttac      300

aacggtaagt tgatcgctta cccaatcgcc gttgaagctt tgtctttaat ctacaataaa      360

gacttattgc caaaccctcc aaagacctgg gaagaaattc ctgccttgga taaggaatta      420

aaggctaaag gtaaatctgc cttaatgttc aacttacaag agccttactt tacttggcca      480

ttgattgctg ctgatggtgg ttatgctttt aagtacgaaa atggtaaata cgacattaaa      540

gatgttggtg ttgacaatgc cggtgctaaa gccggtttaa ctttcttagt cgacttgatc      600

aagaacaagc acatgaatgc tgacactgat tattctatcg ctgaagccgc cttcaacaag      660

ggtgaaactg ctatgactat caatggtcct tgggcctggt ctaatattga cacctccaaa      720

gtcaactacg gtgttactgt cttaccaact ttcaaaggtc aaccttccaa gccatttgtc      780

ggtgttttgt ctgctggtat taacgctgcc tctccaaaca aagaattggc caaggaattt      840

ttggaaaact acttgttgac tgacgaaggt ttagaggctg ttaacaaaga caaaccattg      900

ggtgctgtcg ccttgaaatc ctacgaagaa gaattagcca aggatccaag aatcgccgct      960

accatggaaa atgctcaaaa aggtgaaatt atgccaaaca ttccacaaat gtccgctttt     1020

tggtacgctg ttagaactgc tgttattaat gctgcttctg gtagacaaac tgtcgatgaa     1080

gctttgaagg acgctcaaac cagaatcact aag                                  1113


<210>  171
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS12 Linker

<400>  171
ggaggtggag gaggtggttc cggaggaggt ggttct                                 36


<210>  172
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS12 Linker

<400>  172

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  173
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GB1 tag

<400>  173
atgtctgaca cttacaagtt gatcttgaac ggtaagactt tgaaaggtga aactactacc       60

gaagctgttg atgctgccac tgctgaaaag gtttttaagc aatacgccaa tgataacggt      120

gtcgacggtg aatggactta cgatgatgcc actaagactt ttaccgttac tgaa            174


<210>  174
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GB1 tag

<400>  174

Met Ser Asp Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly 
1               5                   10                  15      


Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe 
            20                  25                  30          


Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp 
        35                  40                  45              


Asp Ala Thr Lys Thr Phe Thr Val Thr Glu 
    50                  55              


<210>  175
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MFalpha1_1-19

<400>  175
atgagatttc cttcaatttt tactgcagtt ttattcgcag catcctccgc attagct          57


<210>  176
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MFalpha1_1-19

<400>  176

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  177
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MFalpha1_1-89

<400>  177
atgagatttc cttcaatttt tactgcagtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tacttagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctttggata aaagagaggc tgaagct                                          267


<210>  178
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MFalpha1_1-89

<400>  178

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Asp Lys Arg Glu Ala Glu Ala 
                85                  


<210>  179
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DasherGFP

<400>  179
atgaccgcac taacagaagg agctaaacta ttcgaaaagg agattcctta cattacagaa       60

ttagagggtg atgtcgaagg aatgaaattc attatcaagg gcgagggtac tggtgacgct      120

actaccggta cgattaaagc aaagtacatc tgtacaacag gtgaccttcc tgttccgtgg      180

gctactctgg tgagcacttt gtcttatgga gttcaatgtt ttgctaaata cccttcgcac      240

attaaagact ttttcaaaag tgcaatgcct gagggctata ctcaggagag aacaatatct      300

ttcgaaggag atggtgtgta taagactagg gctatggtca cgtatgaaag aggatccatc      360

tacaatagag taactttaac tggtgaaaac ttcaaaaagg acggtcacat ccttagaaag      420

aatgttgcct ttcaatgccc accatccatc ttgtacattt tgccagacac agttaacaat      480

ggtatcagag ttgagtttaa ccaagcttat gacatagagg gtgtcaccga aaagttggtt      540

acaaaatgtt cacagatgaa tcgtcccctg gcaggatcag ctgccgtcca tatcccacgt      600

taccatcata tcacttatca taccaagctg tccaaagatc gtgatgagag aagggatcac      660

atgtgtttgg ttgaagtggt aaaggccgtg gatttggata cttaccaagg ttga            714


<210>  180
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DasherGFP

<400>  180

Met Thr Ala Leu Thr Glu Gly Ala Lys Leu Phe Glu Lys Glu Ile Pro 
1               5                   10                  15      


Tyr Ile Thr Glu Leu Glu Gly Asp Val Glu Gly Met Lys Phe Ile Ile 
            20                  25                  30          


Lys Gly Glu Gly Thr Gly Asp Ala Thr Thr Gly Thr Ile Lys Ala Lys 
        35                  40                  45              


Tyr Ile Cys Thr Thr Gly Asp Leu Pro Val Pro Trp Ala Thr Leu Val 
    50                  55                  60                  


Ser Thr Leu Ser Tyr Gly Val Gln Cys Phe Ala Lys Tyr Pro Ser His 
65                  70                  75                  80  


Ile Lys Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Thr Gln Glu 
                85                  90                  95      


Arg Thr Ile Ser Phe Glu Gly Asp Gly Val Tyr Lys Thr Arg Ala Met 
            100                 105                 110         


Val Thr Tyr Glu Arg Gly Ser Ile Tyr Asn Arg Val Thr Leu Thr Gly 
        115                 120                 125             


Glu Asn Phe Lys Lys Asp Gly His Ile Leu Arg Lys Asn Val Ala Phe 
    130                 135                 140                 


Gln Cys Pro Pro Ser Ile Leu Tyr Ile Leu Pro Asp Thr Val Asn Asn 
145                 150                 155                 160 


Gly Ile Arg Val Glu Phe Asn Gln Ala Tyr Asp Ile Glu Gly Val Thr 
                165                 170                 175     


Glu Lys Leu Val Thr Lys Cys Ser Gln Met Asn Arg Pro Leu Ala Gly 
            180                 185                 190         


Ser Ala Ala Val His Ile Pro Arg Tyr His His Ile Thr Tyr His Thr 
        195                 200                 205             


Lys Leu Ser Lys Asp Arg Asp Glu Arg Arg Asp His Met Cys Leu Val 
    210                 215                 220                 


Glu Val Val Lys Ala Val Asp Leu Asp Thr Tyr Gln Gly 
225                 230                 235         


<210>  181
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER1 tag

<400>  181
atattagagc aacctctgaa atttgtgctt actgcggccg tcgtgctctt gacgacgtcg       60

gttctttgtt gtgtagtatt tacataa                                           87


<210>  182
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER1 tag

<400>  182

Ile Leu Glu Gln Pro Leu Lys Phe Val Leu Thr Ala Ala Val Val Leu 
1               5                   10                  15      


Leu Thr Thr Ser Val Leu Cys Cys Val Val Phe Thr 
            20                  25              


<210>  183
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER2 tag

<400>  183
tctacctctg aaaaccaaag taaaggtagt ggtacattgg ttgtcatatt ggccatttta       60

atgctaggtg ttgcttatta tttgttgaac gaataa                                 96


<210>  184
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER2 tag

<400>  184

Ser Thr Ser Glu Asn Gln Ser Lys Gly Ser Gly Thr Leu Val Val Ile 
1               5                   10                  15      


Leu Ala Ile Leu Met Leu Gly Val Ala Tyr Tyr Leu Leu Asn Glu 
            20                  25                  30      


<210>  185
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PM1 tag

<400>  185
tggtacaagg atctaaaaat gaagatgtgt ctggctttag taatcatcat attgcttgtt       60

gtaatcatcg tccccattgc tgttcacttt agtcgataa                              99


<210>  186
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PM1 tag

<400>  186

Trp Tyr Lys Asp Leu Lys Met Lys Met Cys Leu Ala Leu Val Ile Ile 
1               5                   10                  15      


Ile Leu Leu Val Val Ile Ile Val Pro Ile Ala Val His Phe Ser Arg 
            20                  25                  30          


<210>  187
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VC1 tag

<400>  187
aatataaaag aaataatgtg gtggcagaag gtcaaaaata ttacgttatt aactttcact       60

attatactat ttgtaagtgc tgctttcatg tttttctatc tgtggtaa                   108


<210>  188
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VC1 tag

<400>  188

Asn Ile Lys Glu Ile Met Trp Trp Gln Lys Val Lys Asn Ile Thr Leu 
1               5                   10                  15      


Leu Thr Phe Thr Ile Ile Leu Phe Val Ser Ala Ala Phe Met Phe Phe 
            20                  25                  30          


Tyr Leu Trp 
        35  


<210>  189
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PEX8 tag

<400>  189
tctaaattat aa                                                           12


<210>  190
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEX8 tag

<400>  190

Ser Lys Leu 
1           


<210>  191
<211>  2103
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  191
atggttgctc aatataccgt tccagttggg aaagccgcca atgagcatga aactgctcca       60

agaagaaatt atcaatgccg cgagaagccg ctcgtcagac cgcctaacac aaagtgttcc      120

actgtttatg agtttgttct agagtgcttt cagaagaaca aaaattcaaa tgctatgggt      180

tggagggatg ttaaggaaat tcatgaagaa tccaaatcgg ttatgaaaaa agttgatggc      240

aaggagactt cagtggaaaa gaaatggatg tattatgaac tatcgcatta tcattataat      300

tcatttgacc aattgaccga tatcatgcat gaaattggtc gtgggttggt gaaaatagga      360

ttaaagccta atgatgatga caaattacat ctttacgcag ccacttctca caagtggatg      420

aagatgttct taggagcgca gtctcaaggt attcctgtcg tcactgccta cgatactttg      480

ggagagaaag ggctaattca ttctttggtg caaacggggt ctaaggccat ttttaccgat      540

aactctttat taccatcctt gatcaaacca gtgcaagccg ctcaagacgt aaaatacata      600

attcatttcg attccatcag ttctgaggac aggaggcaaa gtggtaagat ctatcaatct      660

gctcatgatg ccatcaacag aattaaagaa gttagacctg atatcaagac ctttagcttt      720

gacgacatct tgaagctagg taaagaatcc tgtaacgaaa tcgatgttca tccacctggc      780

aaggatgatc tttgttgcat catgtatacg tctggttcta caggtgagcc aaagggtgtt      840

gtcttgaaac attcaaatgt tgtcgcaggt gttggtggtg caagtttgaa tgttttgaag      900

tttgtgggca ataccgaccg tgttatctgt tttttgccac tagctcatat ttttgaattg      960

gttttcgaac tattgtcctt ttattggggg gcctgcattg gttatgccac cgtaaaaact     1020

ttaactagca gctctgtgag aaattgtcaa ggtgatttgc aagaattcaa gcccacaatc     1080

atggttggtg tcgccgctgt ttgggaaaca gtgagaaaag ggatcttaaa ccaaattgat     1140

aatttgccct tcctcaccaa gaaaatcttc tggaccgcgt ataataccaa gttgaacatg     1200

caacgtctcc acatccctgg tggcggcgcc ttaggaaact tggttttcaa aaaaatcaga     1260

actgccacag gtggccaatt aagatatttg ttaaacggtg gttctccaat cagtcgggat     1320

gctcaggaat tcatcacaaa tttaatctgc cctatgctta ttggttacgg tttaaccgag     1380

acatgcgcta gtaccaccat cttggatcct gctaattttg aactcggcgt cgctggtgac     1440

ctaacaggtt gtgttaccgt caaactagtt gatgttgaag aattaggtta ttttgctaaa     1500

aacaaccaag gtgaagtttg gatcacaggt gccaatgtca cgcctgaata ttataagaat     1560

gaggaagaaa cttctcaagc tttaacaagc gatggttggt tcaagaccgg tgacatcggt     1620

gaatgggaag caaatggcca tttgaaaata attgacagga agaaaaactt ggtcaaaaca     1680

atgaacggtg aatatatcgc actcgagaaa ttagagtccg tttacagatc taacgaatat     1740

gttgctaaca tttgtgttta tgccgaccaa tctaagacta agccagttgg tattattgta     1800

ccaaatcatg ctccattaac gaagcttgct aaaaagttgg gaattatgga acaaaaagac     1860

agttcaatta atatcgaaaa ttatttggag gatgcaaaat tgattaaagc tgtttattct     1920

gatcttttga agacaggtaa agaccaaggt ttggttggca ttgaattact agcaggcata     1980

gtgttctttg acggcgaatg gactccacaa aacggttttg ttacgtccgc tcagaaattg     2040

aaaagaaaag acattttgaa tgctgtcaaa gataaagttg acgccgttta tagttcgtct     2100

taa                                                                   2103


<210>  192
<211>  700
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  192

Met Val Ala Gln Tyr Thr Val Pro Val Gly Lys Ala Ala Asn Glu His 
1               5                   10                  15      


Glu Thr Ala Pro Arg Arg Asn Tyr Gln Cys Arg Glu Lys Pro Leu Val 
            20                  25                  30          


Arg Pro Pro Asn Thr Lys Cys Ser Thr Val Tyr Glu Phe Val Leu Glu 
        35                  40                  45              


Cys Phe Gln Lys Asn Lys Asn Ser Asn Ala Met Gly Trp Arg Asp Val 
    50                  55                  60                  


Lys Glu Ile His Glu Glu Ser Lys Ser Val Met Lys Lys Val Asp Gly 
65                  70                  75                  80  


Lys Glu Thr Ser Val Glu Lys Lys Trp Met Tyr Tyr Glu Leu Ser His 
                85                  90                  95      


Tyr His Tyr Asn Ser Phe Asp Gln Leu Thr Asp Ile Met His Glu Ile 
            100                 105                 110         


Gly Arg Gly Leu Val Lys Ile Gly Leu Lys Pro Asn Asp Asp Asp Lys 
        115                 120                 125             


Leu His Leu Tyr Ala Ala Thr Ser His Lys Trp Met Lys Met Phe Leu 
    130                 135                 140                 


Gly Ala Gln Ser Gln Gly Ile Pro Val Val Thr Ala Tyr Asp Thr Leu 
145                 150                 155                 160 


Gly Glu Lys Gly Leu Ile His Ser Leu Val Gln Thr Gly Ser Lys Ala 
                165                 170                 175     


Ile Phe Thr Asp Asn Ser Leu Leu Pro Ser Leu Ile Lys Pro Val Gln 
            180                 185                 190         


Ala Ala Gln Asp Val Lys Tyr Ile Ile His Phe Asp Ser Ile Ser Ser 
        195                 200                 205             


Glu Asp Arg Arg Gln Ser Gly Lys Ile Tyr Gln Ser Ala His Asp Ala 
    210                 215                 220                 


Ile Asn Arg Ile Lys Glu Val Arg Pro Asp Ile Lys Thr Phe Ser Phe 
225                 230                 235                 240 


Asp Asp Ile Leu Lys Leu Gly Lys Glu Ser Cys Asn Glu Ile Asp Val 
                245                 250                 255     


His Pro Pro Gly Lys Asp Asp Leu Cys Cys Ile Met Tyr Thr Ser Gly 
            260                 265                 270         


Ser Thr Gly Glu Pro Lys Gly Val Val Leu Lys His Ser Asn Val Val 
        275                 280                 285             


Ala Gly Val Gly Gly Ala Ser Leu Asn Val Leu Lys Phe Val Gly Asn 
    290                 295                 300                 


Thr Asp Arg Val Ile Cys Phe Leu Pro Leu Ala His Ile Phe Glu Leu 
305                 310                 315                 320 


Val Phe Glu Leu Leu Ser Phe Tyr Trp Gly Ala Cys Ile Gly Tyr Ala 
                325                 330                 335     


Thr Val Lys Thr Leu Thr Ser Ser Ser Val Arg Asn Cys Gln Gly Asp 
            340                 345                 350         


Leu Gln Glu Phe Lys Pro Thr Ile Met Val Gly Val Ala Ala Val Trp 
        355                 360                 365             


Glu Thr Val Arg Lys Gly Ile Leu Asn Gln Ile Asp Asn Leu Pro Phe 
    370                 375                 380                 


Leu Thr Lys Lys Ile Phe Trp Thr Ala Tyr Asn Thr Lys Leu Asn Met 
385                 390                 395                 400 


Gln Arg Leu His Ile Pro Gly Gly Gly Ala Leu Gly Asn Leu Val Phe 
                405                 410                 415     


Lys Lys Ile Arg Thr Ala Thr Gly Gly Gln Leu Arg Tyr Leu Leu Asn 
            420                 425                 430         


Gly Gly Ser Pro Ile Ser Arg Asp Ala Gln Glu Phe Ile Thr Asn Leu 
        435                 440                 445             


Ile Cys Pro Met Leu Ile Gly Tyr Gly Leu Thr Glu Thr Cys Ala Ser 
    450                 455                 460                 


Thr Thr Ile Leu Asp Pro Ala Asn Phe Glu Leu Gly Val Ala Gly Asp 
465                 470                 475                 480 


Leu Thr Gly Cys Val Thr Val Lys Leu Val Asp Val Glu Glu Leu Gly 
                485                 490                 495     


Tyr Phe Ala Lys Asn Asn Gln Gly Glu Val Trp Ile Thr Gly Ala Asn 
            500                 505                 510         


Val Thr Pro Glu Tyr Tyr Lys Asn Glu Glu Glu Thr Ser Gln Ala Leu 
        515                 520                 525             


Thr Ser Asp Gly Trp Phe Lys Thr Gly Asp Ile Gly Glu Trp Glu Ala 
    530                 535                 540                 


Asn Gly His Leu Lys Ile Ile Asp Arg Lys Lys Asn Leu Val Lys Thr 
545                 550                 555                 560 


Met Asn Gly Glu Tyr Ile Ala Leu Glu Lys Leu Glu Ser Val Tyr Arg 
                565                 570                 575     


Ser Asn Glu Tyr Val Ala Asn Ile Cys Val Tyr Ala Asp Gln Ser Lys 
            580                 585                 590         


Thr Lys Pro Val Gly Ile Ile Val Pro Asn His Ala Pro Leu Thr Lys 
        595                 600                 605             


Leu Ala Lys Lys Leu Gly Ile Met Glu Gln Lys Asp Ser Ser Ile Asn 
    610                 615                 620                 


Ile Glu Asn Tyr Leu Glu Asp Ala Lys Leu Ile Lys Ala Val Tyr Ser 
625                 630                 635                 640 


Asp Leu Leu Lys Thr Gly Lys Asp Gln Gly Leu Val Gly Ile Glu Leu 
                645                 650                 655     


Leu Ala Gly Ile Val Phe Phe Asp Gly Glu Trp Thr Pro Gln Asn Gly 
            660                 665                 670         


Phe Val Thr Ser Ala Gln Lys Leu Lys Arg Lys Asp Ile Leu Asn Ala 
        675                 680                 685             


Val Lys Asp Lys Val Asp Ala Val Tyr Ser Ser Ser 
    690                 695                 700 


<210>  193
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated medium chain fatty acyl-CoA synthetase Sc_FAA2_Ctrunc

<400>  193
atggccgctc cagattatgc acttaccgat ttaattgaat cggatcctcg tttcgaaagt       60

ttgaagacaa gattagccgg ttacaccaaa ggctctgatg aatatattga agagctatac      120

tctcaattac cactgaccag ctaccccagg tacaaaacat ttttaaagaa acaggcggtt      180

gccatttcga atccggataa tgaagctggt tttagctcga tttataggag ttctctttct      240

tctgaaaatc tagtgagctg tgtggataaa aacttaagaa ctgcatacga tcacttcatg      300

ttttctgcaa ggagatggcc tcaacgtgac tgtttaggtt caaggccaat tgataaagcc      360

acaggcacct gggaggaaac attccgtttc gagtcgtact ccacggtatc taaaagatgt      420

cataatatcg gaagtggtat attgtctttg gtaaacacga aaaggaaacg tcctttggaa      480

gccaatgatt ttgttgttgc tatcttatca cacaacaacc ctgaatggat cctaacagat      540

ttggcctgtc aggcctattc tctaactaac acggctttgt acgaaacatt aggtccaaac      600

acctccgagt acatattgaa tttaaccgag gcccccattc tgatttttgc aaaatcaaat      660

atgtatcatg tattgaagat ggtgcctgat atgaaatttg ttaatacttt ggtttgtatg      720

gatgaattaa ctcatgacga gctccgtatg ctaaatgaat cgttgctacc cgttaagtgc      780

aactctctca atgaaaaaat cacatttttt tcattggagc aggtagaaca agttggttgc      840

tttaacaaaa ttcctgcaat tccacctacc ccagattcct tgtatactat ttcgtttact      900

tctggtacta caggtttacc taaaggtgtg gaaatgtctc acagaaacat tgcgtctggg      960

atagcatttg ctttttctac cttcagaata ccgccagata aaagaaacca acagttatat     1020

gatatgtgtt ttttgccatt ggctcatatt tttgaaagaa tggttattgc gtatgatcta     1080

gccatcgggt ttggaatagg cttcttacat aaaccagacc caactgtatt ggtagaggat     1140

ttgaagattt tgaaacctta cgcggttgcc ctggttccta gaatattaac acggtttgaa     1200

gccggtataa aaaatgcttt ggataaatcg actgtccaga ggaacgtagc aaatactata     1260

ttggattcta aatcggccag atttaccgca agaggtggtc cagataaatc gattatgaat     1320

tttctagttt atcatcgcgt attgattgat aaaatcagag actctttagg tttgtccaat     1380

aactcgttta taattaccgg atcagctccc atatctaaag ataccttact atttttaaga     1440

agcgccttgg atattggtat aagacagggc tacggcttaa ctgaaacttt tgctggtgtc     1500

tgtttaagcg aaccgtttga aaaagatgtc ggatcttgtg gtgccatagg tatttctgca     1560

gaatgtagat tgaagtctgt tccagaaatg ggttaccatg ccgacaagga tttaaaaggt     1620

gaactgcaaa ttcgtggccc acaggttttt gaaagatatt ttaaaaatcc gaatgaaact     1680

tcaaaagccg ttgaccaaga tggttggttt tccacgggag atgttgcatt tatcgatgca     1740

aaaggtcgca tcagcgtcat tgatcgagtc aagaactttt tcaagctagc acatggtgaa     1800

tatattgctc cagagaaaat cgaaaatatt tatttatcat catgccccta tatcacgcaa     1860

atatttgtct ttggagatcc tttgaagaca tttttagttg gcatcgttgg tgttgatgtt     1920

gatgcagcgc aaccgatttt agctgcaaag cacccagagg tgaaaacgtg gactaaggaa     1980

gtgctagtag aaaacttaaa tcgtaataaa aagctaagga aggaattttt aaacaaaatt     2040

aataaatgca tcgatgggct acaaggattt gaaaaattgc acaacatcaa agtcggactt     2100

gagcctttga ctctcgagga tgatgttgtg acgccaactt ttaaaataaa gcgtgccaaa     2160

gcatcaaaat tcttcaaaga tacattagac caactatacg ccgaaggttc actagtcaag     2220

acatag                                                                2226


<210>  194
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated medium chain fatty acyl-CoA synthetase Sc_FAA2_Ctrunc

<400>  194

Met Ala Ala Pro Asp Tyr Ala Leu Thr Asp Leu Ile Glu Ser Asp Pro 
1               5                   10                  15      


Arg Phe Glu Ser Leu Lys Thr Arg Leu Ala Gly Tyr Thr Lys Gly Ser 
            20                  25                  30          


Asp Glu Tyr Ile Glu Glu Leu Tyr Ser Gln Leu Pro Leu Thr Ser Tyr 
        35                  40                  45              


Pro Arg Tyr Lys Thr Phe Leu Lys Lys Gln Ala Val Ala Ile Ser Asn 
    50                  55                  60                  


Pro Asp Asn Glu Ala Gly Phe Ser Ser Ile Tyr Arg Ser Ser Leu Ser 
65                  70                  75                  80  


Ser Glu Asn Leu Val Ser Cys Val Asp Lys Asn Leu Arg Thr Ala Tyr 
                85                  90                  95      


Asp His Phe Met Phe Ser Ala Arg Arg Trp Pro Gln Arg Asp Cys Leu 
            100                 105                 110         


Gly Ser Arg Pro Ile Asp Lys Ala Thr Gly Thr Trp Glu Glu Thr Phe 
        115                 120                 125             


Arg Phe Glu Ser Tyr Ser Thr Val Ser Lys Arg Cys His Asn Ile Gly 
    130                 135                 140                 


Ser Gly Ile Leu Ser Leu Val Asn Thr Lys Arg Lys Arg Pro Leu Glu 
145                 150                 155                 160 


Ala Asn Asp Phe Val Val Ala Ile Leu Ser His Asn Asn Pro Glu Trp 
                165                 170                 175     


Ile Leu Thr Asp Leu Ala Cys Gln Ala Tyr Ser Leu Thr Asn Thr Ala 
            180                 185                 190         


Leu Tyr Glu Thr Leu Gly Pro Asn Thr Ser Glu Tyr Ile Leu Asn Leu 
        195                 200                 205             


Thr Glu Ala Pro Ile Leu Ile Phe Ala Lys Ser Asn Met Tyr His Val 
    210                 215                 220                 


Leu Lys Met Val Pro Asp Met Lys Phe Val Asn Thr Leu Val Cys Met 
225                 230                 235                 240 


Asp Glu Leu Thr His Asp Glu Leu Arg Met Leu Asn Glu Ser Leu Leu 
                245                 250                 255     


Pro Val Lys Cys Asn Ser Leu Asn Glu Lys Ile Thr Phe Phe Ser Leu 
            260                 265                 270         


Glu Gln Val Glu Gln Val Gly Cys Phe Asn Lys Ile Pro Ala Ile Pro 
        275                 280                 285             


Pro Thr Pro Asp Ser Leu Tyr Thr Ile Ser Phe Thr Ser Gly Thr Thr 
    290                 295                 300                 


Gly Leu Pro Lys Gly Val Glu Met Ser His Arg Asn Ile Ala Ser Gly 
305                 310                 315                 320 


Ile Ala Phe Ala Phe Ser Thr Phe Arg Ile Pro Pro Asp Lys Arg Asn 
                325                 330                 335     


Gln Gln Leu Tyr Asp Met Cys Phe Leu Pro Leu Ala His Ile Phe Glu 
            340                 345                 350         


Arg Met Val Ile Ala Tyr Asp Leu Ala Ile Gly Phe Gly Ile Gly Phe 
        355                 360                 365             


Leu His Lys Pro Asp Pro Thr Val Leu Val Glu Asp Leu Lys Ile Leu 
    370                 375                 380                 


Lys Pro Tyr Ala Val Ala Leu Val Pro Arg Ile Leu Thr Arg Phe Glu 
385                 390                 395                 400 


Ala Gly Ile Lys Asn Ala Leu Asp Lys Ser Thr Val Gln Arg Asn Val 
                405                 410                 415     


Ala Asn Thr Ile Leu Asp Ser Lys Ser Ala Arg Phe Thr Ala Arg Gly 
            420                 425                 430         


Gly Pro Asp Lys Ser Ile Met Asn Phe Leu Val Tyr His Arg Val Leu 
        435                 440                 445             


Ile Asp Lys Ile Arg Asp Ser Leu Gly Leu Ser Asn Asn Ser Phe Ile 
    450                 455                 460                 


Ile Thr Gly Ser Ala Pro Ile Ser Lys Asp Thr Leu Leu Phe Leu Arg 
465                 470                 475                 480 


Ser Ala Leu Asp Ile Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr 
                485                 490                 495     


Phe Ala Gly Val Cys Leu Ser Glu Pro Phe Glu Lys Asp Val Gly Ser 
            500                 505                 510         


Cys Gly Ala Ile Gly Ile Ser Ala Glu Cys Arg Leu Lys Ser Val Pro 
        515                 520                 525             


Glu Met Gly Tyr His Ala Asp Lys Asp Leu Lys Gly Glu Leu Gln Ile 
    530                 535                 540                 


Arg Gly Pro Gln Val Phe Glu Arg Tyr Phe Lys Asn Pro Asn Glu Thr 
545                 550                 555                 560 


Ser Lys Ala Val Asp Gln Asp Gly Trp Phe Ser Thr Gly Asp Val Ala 
                565                 570                 575     


Phe Ile Asp Ala Lys Gly Arg Ile Ser Val Ile Asp Arg Val Lys Asn 
            580                 585                 590         


Phe Phe Lys Leu Ala His Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu 
        595                 600                 605             


Asn Ile Tyr Leu Ser Ser Cys Pro Tyr Ile Thr Gln Ile Phe Val Phe 
    610                 615                 620                 


Gly Asp Pro Leu Lys Thr Phe Leu Val Gly Ile Val Gly Val Asp Val 
625                 630                 635                 640 


Asp Ala Ala Gln Pro Ile Leu Ala Ala Lys His Pro Glu Val Lys Thr 
                645                 650                 655     


Trp Thr Lys Glu Val Leu Val Glu Asn Leu Asn Arg Asn Lys Lys Leu 
            660                 665                 670         


Arg Lys Glu Phe Leu Asn Lys Ile Asn Lys Cys Ile Asp Gly Leu Gln 
        675                 680                 685             


Gly Phe Glu Lys Leu His Asn Ile Lys Val Gly Leu Glu Pro Leu Thr 
    690                 695                 700                 


Leu Glu Asp Asp Val Val Thr Pro Thr Phe Lys Ile Lys Arg Ala Lys 
705                 710                 715                 720 


Ala Ser Lys Phe Phe Lys Asp Thr Leu Asp Gln Leu Tyr Ala Glu Gly 
                725                 730                 735     


Ser Leu Val Lys Thr 
            740     


<210>  195
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated medium chain fatty acyl-CoA synthetase Sc_FAA2_Cmut

<400>  195
atggccgctc cagattatgc acttaccgat ttaattgaat cggatcctcg tttcgaaagt       60

ttgaagacaa gattagccgg ttacaccaaa ggctctgatg aatatattga agagctatac      120

tctcaattac cactgaccag ctaccccagg tacaaaacat ttttaaagaa acaggcggtt      180

gccatttcga atccggataa tgaagctggt tttagctcga tttataggag ttctctttct      240

tctgaaaatc tagtgagctg tgtggataaa aacttaagaa ctgcatacga tcacttcatg      300

ttttctgcaa ggagatggcc tcaacgtgac tgtttaggtt caaggccaat tgataaagcc      360

acaggcacct gggaggaaac attccgtttc gagtcgtact ccacggtatc taaaagatgt      420

cataatatcg gaagtggtat attgtctttg gtaaacacga aaaggaaacg tcctttggaa      480

gccaatgatt ttgttgttgc tatcttatca cacaacaacc ctgaatggat cctaacagat      540

ttggcctgtc aggcctattc tctaactaac acggctttgt acgaaacatt aggtccaaac      600

acctccgagt acatattgaa tttaaccgag gcccccattc tgatttttgc aaaatcaaat      660

atgtatcatg tattgaagat ggtgcctgat atgaaatttg ttaatacttt ggtttgtatg      720

gatgaattaa ctcatgacga gctccgtatg ctaaatgaat cgttgctacc cgttaagtgc      780

aactctctca atgaaaaaat cacatttttt tcattggagc aggtagaaca agttggttgc      840

tttaacaaaa ttcctgcaat tccacctacc ccagattcct tgtatactat ttcgtttact      900

tctggtacta caggtttacc taaaggtgtg gaaatgtctc acagaaacat tgcgtctggg      960

atagcatttg ctttttctac cttcagaata ccgccagata aaagaaacca acagttatat     1020

gatatgtgtt ttttgccatt ggctcatatt tttgaaagaa tggttattgc gtatgatcta     1080

gccatcgggt ttggaatagg cttcttacat aaaccagacc caactgtatt ggtagaggat     1140

ttgaagattt tgaaacctta cgcggttgcc ctggttccta gaatattaac acggtttgaa     1200

gccggtataa aaaatgcttt ggataaatcg actgtccaga ggaacgtagc aaatactata     1260

ttggattcta aatcggccag atttaccgca agaggtggtc cagataaatc gattatgaat     1320

tttctagttt atcatcgcgt attgattgat aaaatcagag actctttagg tttgtccaat     1380

aactcgttta taattaccgg atcagctccc atatctaaag ataccttact atttttaaga     1440

agcgccttgg atattggtat aagacagggc tacggcttaa ctgaaacttt tgctggtgtc     1500

tgtttaagcg aaccgtttga aaaagatgtc ggatcttgtg gtgccatagg tatttctgca     1560

gaatgtagat tgaagtctgt tccagaaatg ggttaccatg ccgacaagga tttaaaaggt     1620

gaactgcaaa ttcgtggccc acaggttttt gaaagatatt ttaaaaatcc gaatgaaact     1680

tcaaaagccg ttgaccaaga tggttggttt tccacgggag atgttgcatt tatcgatgca     1740

aaaggtcgca tcagcgtcat tgatcgagtc aagaactttt tcaagctagc acatggtgaa     1800

tatattgctc cagagaaaat cgaaaatatt tatttatcat catgccccta tatcacgcaa     1860

atatttgtct ttggagatcc tttgaagaca tttttagttg gcatcgttgg tgttgatgtt     1920

gatgcagcgc aaccgatttt agctgcaaag cacccagagg tgaaaacgtg gactaaggaa     1980

gtgctagtag aaaacttaaa tcgtaataaa aagctaagga aggaattttt aaacaaaatt     2040

aataaatgca tcgatgggct acaaggattt gaaaaattgc acaacatcaa agtcggactt     2100

gagcctttga ctctcgagga tgatgttgtg acgccaactt ttaaaataaa gcgtgccaaa     2160

gcatcaaaat tcttcaaaga tacattagac caactatacg ccgaaggttc actagtcaag     2220

acagaaaagc ttaaatag                                                   2238


<210>  196
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated medium chain fatty acyl-CoA synthetase Sc_FAA2_Cmut

<400>  196

Met Ala Ala Pro Asp Tyr Ala Leu Thr Asp Leu Ile Glu Ser Asp Pro 
1               5                   10                  15      


Arg Phe Glu Ser Leu Lys Thr Arg Leu Ala Gly Tyr Thr Lys Gly Ser 
            20                  25                  30          


Asp Glu Tyr Ile Glu Glu Leu Tyr Ser Gln Leu Pro Leu Thr Ser Tyr 
        35                  40                  45              


Pro Arg Tyr Lys Thr Phe Leu Lys Lys Gln Ala Val Ala Ile Ser Asn 
    50                  55                  60                  


Pro Asp Asn Glu Ala Gly Phe Ser Ser Ile Tyr Arg Ser Ser Leu Ser 
65                  70                  75                  80  


Ser Glu Asn Leu Val Ser Cys Val Asp Lys Asn Leu Arg Thr Ala Tyr 
                85                  90                  95      


Asp His Phe Met Phe Ser Ala Arg Arg Trp Pro Gln Arg Asp Cys Leu 
            100                 105                 110         


Gly Ser Arg Pro Ile Asp Lys Ala Thr Gly Thr Trp Glu Glu Thr Phe 
        115                 120                 125             


Arg Phe Glu Ser Tyr Ser Thr Val Ser Lys Arg Cys His Asn Ile Gly 
    130                 135                 140                 


Ser Gly Ile Leu Ser Leu Val Asn Thr Lys Arg Lys Arg Pro Leu Glu 
145                 150                 155                 160 


Ala Asn Asp Phe Val Val Ala Ile Leu Ser His Asn Asn Pro Glu Trp 
                165                 170                 175     


Ile Leu Thr Asp Leu Ala Cys Gln Ala Tyr Ser Leu Thr Asn Thr Ala 
            180                 185                 190         


Leu Tyr Glu Thr Leu Gly Pro Asn Thr Ser Glu Tyr Ile Leu Asn Leu 
        195                 200                 205             


Thr Glu Ala Pro Ile Leu Ile Phe Ala Lys Ser Asn Met Tyr His Val 
    210                 215                 220                 


Leu Lys Met Val Pro Asp Met Lys Phe Val Asn Thr Leu Val Cys Met 
225                 230                 235                 240 


Asp Glu Leu Thr His Asp Glu Leu Arg Met Leu Asn Glu Ser Leu Leu 
                245                 250                 255     


Pro Val Lys Cys Asn Ser Leu Asn Glu Lys Ile Thr Phe Phe Ser Leu 
            260                 265                 270         


Glu Gln Val Glu Gln Val Gly Cys Phe Asn Lys Ile Pro Ala Ile Pro 
        275                 280                 285             


Pro Thr Pro Asp Ser Leu Tyr Thr Ile Ser Phe Thr Ser Gly Thr Thr 
    290                 295                 300                 


Gly Leu Pro Lys Gly Val Glu Met Ser His Arg Asn Ile Ala Ser Gly 
305                 310                 315                 320 


Ile Ala Phe Ala Phe Ser Thr Phe Arg Ile Pro Pro Asp Lys Arg Asn 
                325                 330                 335     


Gln Gln Leu Tyr Asp Met Cys Phe Leu Pro Leu Ala His Ile Phe Glu 
            340                 345                 350         


Arg Met Val Ile Ala Tyr Asp Leu Ala Ile Gly Phe Gly Ile Gly Phe 
        355                 360                 365             


Leu His Lys Pro Asp Pro Thr Val Leu Val Glu Asp Leu Lys Ile Leu 
    370                 375                 380                 


Lys Pro Tyr Ala Val Ala Leu Val Pro Arg Ile Leu Thr Arg Phe Glu 
385                 390                 395                 400 


Ala Gly Ile Lys Asn Ala Leu Asp Lys Ser Thr Val Gln Arg Asn Val 
                405                 410                 415     


Ala Asn Thr Ile Leu Asp Ser Lys Ser Ala Arg Phe Thr Ala Arg Gly 
            420                 425                 430         


Gly Pro Asp Lys Ser Ile Met Asn Phe Leu Val Tyr His Arg Val Leu 
        435                 440                 445             


Ile Asp Lys Ile Arg Asp Ser Leu Gly Leu Ser Asn Asn Ser Phe Ile 
    450                 455                 460                 


Ile Thr Gly Ser Ala Pro Ile Ser Lys Asp Thr Leu Leu Phe Leu Arg 
465                 470                 475                 480 


Ser Ala Leu Asp Ile Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr 
                485                 490                 495     


Phe Ala Gly Val Cys Leu Ser Glu Pro Phe Glu Lys Asp Val Gly Ser 
            500                 505                 510         


Cys Gly Ala Ile Gly Ile Ser Ala Glu Cys Arg Leu Lys Ser Val Pro 
        515                 520                 525             


Glu Met Gly Tyr His Ala Asp Lys Asp Leu Lys Gly Glu Leu Gln Ile 
    530                 535                 540                 


Arg Gly Pro Gln Val Phe Glu Arg Tyr Phe Lys Asn Pro Asn Glu Thr 
545                 550                 555                 560 


Ser Lys Ala Val Asp Gln Asp Gly Trp Phe Ser Thr Gly Asp Val Ala 
                565                 570                 575     


Phe Ile Asp Ala Lys Gly Arg Ile Ser Val Ile Asp Arg Val Lys Asn 
            580                 585                 590         


Phe Phe Lys Leu Ala His Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu 
        595                 600                 605             


Asn Ile Tyr Leu Ser Ser Cys Pro Tyr Ile Thr Gln Ile Phe Val Phe 
    610                 615                 620                 


Gly Asp Pro Leu Lys Thr Phe Leu Val Gly Ile Val Gly Val Asp Val 
625                 630                 635                 640 


Asp Ala Ala Gln Pro Ile Leu Ala Ala Lys His Pro Glu Val Lys Thr 
                645                 650                 655     


Trp Thr Lys Glu Val Leu Val Glu Asn Leu Asn Arg Asn Lys Lys Leu 
            660                 665                 670         


Arg Lys Glu Phe Leu Asn Lys Ile Asn Lys Cys Ile Asp Gly Leu Gln 
        675                 680                 685             


Gly Phe Glu Lys Leu His Asn Ile Lys Val Gly Leu Glu Pro Leu Thr 
    690                 695                 700                 


Leu Glu Asp Asp Val Val Thr Pro Thr Phe Lys Ile Lys Arg Ala Lys 
705                 710                 715                 720 


Ala Ser Lys Phe Phe Lys Asp Thr Leu Asp Gln Leu Tyr Ala Glu Gly 
                725                 730                 735     


Ser Leu Val Lys Thr Glu Lys Leu Lys 
            740                 745 


<210>  197
<211>  2085
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  197
atgtccgaac aacactctgt cgcagtcggt aaagctgcta atgagcacga gactgcccct       60

aggagaaatg ttagagtcaa gaagcggccc ttaattagac cattgaactc gtcagcatct      120

acgctgtatg aatttgccct agagtgtttc aacaagggtg gaaaacgaga tggtatggct      180

tggagagatg tcatcgagat tcatgagaca aagaaaacca ttgtgagaaa ggtagacggc      240

aaggataaat ctatagaaaa gacatggctg tattatgaaa tgtcaccata taaaatgatg      300

acctaccagg aactgatctg ggtgatgcac gatatgggcc gtgggctggc aaaaataggc      360

atcaagccca atggagaaca caaattccac atcttcgcat ctacttccca taaatggatg      420

aagattttcc ttggttgcat atcccagggt atccccgtag taaccgcgta tgatactttg      480

ggtgagagcg gtttgattca ctccatggtt gaaaccgagt ctgctgctat tttcactgat      540

aatcaattat tggctaaaat gatagtgcct ttgcaatctg ctaaagatat caaatttctt      600

atccataacg aacctatcga ccccaatgac agaagacaaa acggcaaact ttacaaggct      660

gctaaggatg ccattaataa gatcagagaa gttaggccag acataaaaat ttatagtttt      720

gaagaagttg tcaagatagg taaaaaaagt aaagatgagg tcaaacttca tccacctgag      780

ccaaaagatt tggcttgtat catgtacacc tcgggctcga tcagtgcacc aaaaggtgta      840

gtattgactc attataatat tgtttcgggt atcgctggtg taggtcacaa cgtctttgga      900

tggatcggct ctacagaccg tgttttgtcg ttcttgccat tggctcatat ttttgaactg      960

gtctttgaat tcgaagcctt ttactggaac ggtattcttg ggtacggtag tgttaagact     1020

ttgactaata cttcgactcg taattgtaag ggtgacctgg ttgagtttaa gcctactatt     1080

atgatcggtg tggctgccgt ttgggaaact gtgagaaaag ctattttgga aaagatcagc     1140

gatttaactc ccgtactcca aaagattttt tggtctgcct atagtatgaa agaaaagagt     1200

gtaccatgca ccgggttttt aagtcgtatg gtcttcaaga aagtcagaca agccaccggt     1260

ggtcatctta agtatattat gaacggtggg tctgcgatca gtattgatgc tcagaaattc     1320

ttttctatcg tcctgtgtcc tatgattatc ggttacggcc ttactgaaac agttgcgaat     1380

gcttgtgttt tggagcctga tcatttcgaa tatggtatag ttggtgatct tgttggatcg     1440

gtcactgcca aattggtgga tgttaaggac ctaggttatt atgcaaaaaa caatcaaggt     1500

gaattgcttc taaagggtgc gccggtctgt tctgaatatt ataagaatcc aatagaaacg     1560

gcggtctctt tcacttacga tggatggttt cgtactggtg atattgttga atggactccc     1620

aagggacaac ttaaaattat tgatagaaga aagaatttgg ttaaaaccct aaatggtgaa     1680

tatattgcat tagaaaagtt agaatctgtt tacaggtcaa actcctatgt gaaaaatatc     1740

tgtgtttatg ccgatgaaag tagggttaaa ccggtgggta ttgtggtacc caacccagga     1800

cccctatcta aatttgctgt caaattgcgt attatgaaaa agggtgaaga catcgaaaac     1860

tatatccatg acaaagcatt acgaaatgct gttttcaaag agatgatcgc aacagccaaa     1920

tctcaaggtt tggttggtat tgaactatta tgtggtattg ttttctttga tgaagaatgg     1980

acacctgaaa atggctttgt cacatctgct caaaaattaa agagaagaga aatcttagcc     2040

gctgttaaat cagaagtcga aagggtttac aaagaaaatt cttag                     2085


<210>  198
<211>  694
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  198

Met Ser Glu Gln His Ser Val Ala Val Gly Lys Ala Ala Asn Glu His 
1               5                   10                  15      


Glu Thr Ala Pro Arg Arg Asn Val Arg Val Lys Lys Arg Pro Leu Ile 
            20                  25                  30          


Arg Pro Leu Asn Ser Ser Ala Ser Thr Leu Tyr Glu Phe Ala Leu Glu 
        35                  40                  45              


Cys Phe Asn Lys Gly Gly Lys Arg Asp Gly Met Ala Trp Arg Asp Val 
    50                  55                  60                  


Ile Glu Ile His Glu Thr Lys Lys Thr Ile Val Arg Lys Val Asp Gly 
65                  70                  75                  80  


Lys Asp Lys Ser Ile Glu Lys Thr Trp Leu Tyr Tyr Glu Met Ser Pro 
                85                  90                  95      


Tyr Lys Met Met Thr Tyr Gln Glu Leu Ile Trp Val Met His Asp Met 
            100                 105                 110         


Gly Arg Gly Leu Ala Lys Ile Gly Ile Lys Pro Asn Gly Glu His Lys 
        115                 120                 125             


Phe His Ile Phe Ala Ser Thr Ser His Lys Trp Met Lys Ile Phe Leu 
    130                 135                 140                 


Gly Cys Ile Ser Gln Gly Ile Pro Val Val Thr Ala Tyr Asp Thr Leu 
145                 150                 155                 160 


Gly Glu Ser Gly Leu Ile His Ser Met Val Glu Thr Glu Ser Ala Ala 
                165                 170                 175     


Ile Phe Thr Asp Asn Gln Leu Leu Ala Lys Met Ile Val Pro Leu Gln 
            180                 185                 190         


Ser Ala Lys Asp Ile Lys Phe Leu Ile His Asn Glu Pro Ile Asp Pro 
        195                 200                 205             


Asn Asp Arg Arg Gln Asn Gly Lys Leu Tyr Lys Ala Ala Lys Asp Ala 
    210                 215                 220                 


Ile Asn Lys Ile Arg Glu Val Arg Pro Asp Ile Lys Ile Tyr Ser Phe 
225                 230                 235                 240 


Glu Glu Val Val Lys Ile Gly Lys Lys Ser Lys Asp Glu Val Lys Leu 
                245                 250                 255     


His Pro Pro Glu Pro Lys Asp Leu Ala Cys Ile Met Tyr Thr Ser Gly 
            260                 265                 270         


Ser Ile Ser Ala Pro Lys Gly Val Val Leu Thr His Tyr Asn Ile Val 
        275                 280                 285             


Ser Gly Ile Ala Gly Val Gly His Asn Val Phe Gly Trp Ile Gly Ser 
    290                 295                 300                 


Thr Asp Arg Val Leu Ser Phe Leu Pro Leu Ala His Ile Phe Glu Leu 
305                 310                 315                 320 


Val Phe Glu Phe Glu Ala Phe Tyr Trp Asn Gly Ile Leu Gly Tyr Gly 
                325                 330                 335     


Ser Val Lys Thr Leu Thr Asn Thr Ser Thr Arg Asn Cys Lys Gly Asp 
            340                 345                 350         


Leu Val Glu Phe Lys Pro Thr Ile Met Ile Gly Val Ala Ala Val Trp 
        355                 360                 365             


Glu Thr Val Arg Lys Ala Ile Leu Glu Lys Ile Ser Asp Leu Thr Pro 
    370                 375                 380                 


Val Leu Gln Lys Ile Phe Trp Ser Ala Tyr Ser Met Lys Glu Lys Ser 
385                 390                 395                 400 


Val Pro Cys Thr Gly Phe Leu Ser Arg Met Val Phe Lys Lys Val Arg 
                405                 410                 415     


Gln Ala Thr Gly Gly His Leu Lys Tyr Ile Met Asn Gly Gly Ser Ala 
            420                 425                 430         


Ile Ser Ile Asp Ala Gln Lys Phe Phe Ser Ile Val Leu Cys Pro Met 
        435                 440                 445             


Ile Ile Gly Tyr Gly Leu Thr Glu Thr Val Ala Asn Ala Cys Val Leu 
    450                 455                 460                 


Glu Pro Asp His Phe Glu Tyr Gly Ile Val Gly Asp Leu Val Gly Ser 
465                 470                 475                 480 


Val Thr Ala Lys Leu Val Asp Val Lys Asp Leu Gly Tyr Tyr Ala Lys 
                485                 490                 495     


Asn Asn Gln Gly Glu Leu Leu Leu Lys Gly Ala Pro Val Cys Ser Glu 
            500                 505                 510         


Tyr Tyr Lys Asn Pro Ile Glu Thr Ala Val Ser Phe Thr Tyr Asp Gly 
        515                 520                 525             


Trp Phe Arg Thr Gly Asp Ile Val Glu Trp Thr Pro Lys Gly Gln Leu 
    530                 535                 540                 


Lys Ile Ile Asp Arg Arg Lys Asn Leu Val Lys Thr Leu Asn Gly Glu 
545                 550                 555                 560 


Tyr Ile Ala Leu Glu Lys Leu Glu Ser Val Tyr Arg Ser Asn Ser Tyr 
                565                 570                 575     


Val Lys Asn Ile Cys Val Tyr Ala Asp Glu Ser Arg Val Lys Pro Val 
            580                 585                 590         


Gly Ile Val Val Pro Asn Pro Gly Pro Leu Ser Lys Phe Ala Val Lys 
        595                 600                 605             


Leu Arg Ile Met Lys Lys Gly Glu Asp Ile Glu Asn Tyr Ile His Asp 
    610                 615                 620                 


Lys Ala Leu Arg Asn Ala Val Phe Lys Glu Met Ile Ala Thr Ala Lys 
625                 630                 635                 640 


Ser Gln Gly Leu Val Gly Ile Glu Leu Leu Cys Gly Ile Val Phe Phe 
                645                 650                 655     


Asp Glu Glu Trp Thr Pro Glu Asn Gly Phe Val Thr Ser Ala Gln Lys 
            660                 665                 670         


Leu Lys Arg Arg Glu Ile Leu Ala Ala Val Lys Ser Glu Val Glu Arg 
        675                 680                 685             


Val Tyr Lys Glu Asn Ser 
    690                 


<210>  199
<211>  2085
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  199
atgaccgaac aatattccgt tgcagttggc gaagccgaca atgagcatga aaccgctcca       60

agaagaaata tcagggttaa agacaagcct ttgattagac ccataaactc ctcagcatct      120

acactgtacg aattcgccct ggaatgtttt accaaaggtg gtaagagaga cggtatggca      180

tggagagata ttatagatat acatgagacg aaaaaaacca tagtcaagag ggtggatggt      240

aaggataagc ccatcgaaaa aacatggttg tactacgaac tgactcccta cataaccatg      300

acatacgagg agatgatctg cgtaatgcac gacattggac gtgggctgat aaagattggt      360

gttaaaccta acggtgagaa caagttccac atctttgcct ctacatctca caagtggatg      420

aaaacttttc ttggttgcat gtcacaaggt attcctgtgg tcaccgcgta cgacactttg      480

ggtgagagcg gtttgattca ctccatggtg gaaacggatt ccgtcgccat tttcacggac      540

aaccagctgt tgtccaaatt agcagttcct ttgaaaaccg ccaagaacgt aaaattcgtc      600

attcacaacg aacccatcga tccaagtgac aaaagacaaa atggtaagct ttacaaggct      660

gccaaggatg ctgttgacaa aatcaaggaa gttagaccgg acataaaaat ctacagtttc      720

gatgaaatta ttgagatagg taaaaaggcc aaggacgagg ttgaattgca tttccccaag      780

cctgaagatc cagcttgtat catgtacact tctggttcca ctggtacacc aaagggtgtg      840

gtattgacac attacaacat tgtagctggt attggtggtg tgggccataa cgttatcgga      900

tggattggcc caacagaccg tattatcgca ttcttgccat tggctcatat ttttgaatta      960

atctttgaat tcgaagcgtt ctactggaat ggtatcctag ggtacgccac tgtcaagact     1020

ttaaccccaa cttctacacg taattgccaa ggtgacctga tggagtttaa acctaccgta     1080

atggtaggtg ttgccgcagt ttgggaaaca gtgagaaaag gtatcctggc caagatcaac     1140

gaattgcccg gttggtctca aacgcttttc tggactgtct atgctttgaa agagagaaat     1200

ataccatgca gcggcttgct gagtgggttg atcttcaaga gaatcagaga agcaaccggt     1260

ggaaacttaa ggtttattct gaacggtggg tctgcaatca gcatagacgc ccaaaaattc     1320

ctctccaacc ttctatgtcc tatgctcatt ggatatgggc taactgaggg tgtggctaat     1380

gcctgtgtcc tggagcctga acattttgat tacggtattg ctggtgacct tgtcggaact     1440

attacagcta aattggtgga tgtcgaagat ttgggctatt ttgccaagaa taaccaaggt     1500

gaattgctgt taaagggtgc acccatctgt tctgaatact ataagaatcc tgaagaaact     1560

gctgcggcct ttaccgatga tggctggttc cgtaccggtg atatcgctga atggaccccc     1620

aagggacaaa ttaagatcat tgatagaaag aaaaatttgg tcaagacctt aaacggtgag     1680

tacattgcat tggaaaaatt agaatccatt tacagatcaa atccttacgt ccaaaacatc     1740

tgtgtctacg ctgatgaaaa caaagttaag cctgtcggta ttgtggtccc taacttagga     1800

cacttgtcta agctggctat cgaattaggt ataatggtac caggtgaaga tgtcgaaagc     1860

tatatccatg aaaagaagct acaggatgcc gtttgcaaag atatgctgtc aactgccaaa     1920

tctcaaggct tgaatggtat tgaattatta tgtggcattg ttttctttga agaagaatgg     1980

actccagaaa acggtcttgt tacatccgcc caaaaattaa agagaagaga tattctagcg     2040

gctgtcaagc cagatgtgga aagagtttat aaagaaaaca cttaa                     2085


<210>  200
<211>  694
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  200

Met Thr Glu Gln Tyr Ser Val Ala Val Gly Glu Ala Asp Asn Glu His 
1               5                   10                  15      


Glu Thr Ala Pro Arg Arg Asn Ile Arg Val Lys Asp Lys Pro Leu Ile 
            20                  25                  30          


Arg Pro Ile Asn Ser Ser Ala Ser Thr Leu Tyr Glu Phe Ala Leu Glu 
        35                  40                  45              


Cys Phe Thr Lys Gly Gly Lys Arg Asp Gly Met Ala Trp Arg Asp Ile 
    50                  55                  60                  


Ile Asp Ile His Glu Thr Lys Lys Thr Ile Val Lys Arg Val Asp Gly 
65                  70                  75                  80  


Lys Asp Lys Pro Ile Glu Lys Thr Trp Leu Tyr Tyr Glu Leu Thr Pro 
                85                  90                  95      


Tyr Ile Thr Met Thr Tyr Glu Glu Met Ile Cys Val Met His Asp Ile 
            100                 105                 110         


Gly Arg Gly Leu Ile Lys Ile Gly Val Lys Pro Asn Gly Glu Asn Lys 
        115                 120                 125             


Phe His Ile Phe Ala Ser Thr Ser His Lys Trp Met Lys Thr Phe Leu 
    130                 135                 140                 


Gly Cys Met Ser Gln Gly Ile Pro Val Val Thr Ala Tyr Asp Thr Leu 
145                 150                 155                 160 


Gly Glu Ser Gly Leu Ile His Ser Met Val Glu Thr Asp Ser Val Ala 
                165                 170                 175     


Ile Phe Thr Asp Asn Gln Leu Leu Ser Lys Leu Ala Val Pro Leu Lys 
            180                 185                 190         


Thr Ala Lys Asn Val Lys Phe Val Ile His Asn Glu Pro Ile Asp Pro 
        195                 200                 205             


Ser Asp Lys Arg Gln Asn Gly Lys Leu Tyr Lys Ala Ala Lys Asp Ala 
    210                 215                 220                 


Val Asp Lys Ile Lys Glu Val Arg Pro Asp Ile Lys Ile Tyr Ser Phe 
225                 230                 235                 240 


Asp Glu Ile Ile Glu Ile Gly Lys Lys Ala Lys Asp Glu Val Glu Leu 
                245                 250                 255     


His Phe Pro Lys Pro Glu Asp Pro Ala Cys Ile Met Tyr Thr Ser Gly 
            260                 265                 270         


Ser Thr Gly Thr Pro Lys Gly Val Val Leu Thr His Tyr Asn Ile Val 
        275                 280                 285             


Ala Gly Ile Gly Gly Val Gly His Asn Val Ile Gly Trp Ile Gly Pro 
    290                 295                 300                 


Thr Asp Arg Ile Ile Ala Phe Leu Pro Leu Ala His Ile Phe Glu Leu 
305                 310                 315                 320 


Ile Phe Glu Phe Glu Ala Phe Tyr Trp Asn Gly Ile Leu Gly Tyr Ala 
                325                 330                 335     


Thr Val Lys Thr Leu Thr Pro Thr Ser Thr Arg Asn Cys Gln Gly Asp 
            340                 345                 350         


Leu Met Glu Phe Lys Pro Thr Val Met Val Gly Val Ala Ala Val Trp 
        355                 360                 365             


Glu Thr Val Arg Lys Gly Ile Leu Ala Lys Ile Asn Glu Leu Pro Gly 
    370                 375                 380                 


Trp Ser Gln Thr Leu Phe Trp Thr Val Tyr Ala Leu Lys Glu Arg Asn 
385                 390                 395                 400 


Ile Pro Cys Ser Gly Leu Leu Ser Gly Leu Ile Phe Lys Arg Ile Arg 
                405                 410                 415     


Glu Ala Thr Gly Gly Asn Leu Arg Phe Ile Leu Asn Gly Gly Ser Ala 
            420                 425                 430         


Ile Ser Ile Asp Ala Gln Lys Phe Leu Ser Asn Leu Leu Cys Pro Met 
        435                 440                 445             


Leu Ile Gly Tyr Gly Leu Thr Glu Gly Val Ala Asn Ala Cys Val Leu 
    450                 455                 460                 


Glu Pro Glu His Phe Asp Tyr Gly Ile Ala Gly Asp Leu Val Gly Thr 
465                 470                 475                 480 


Ile Thr Ala Lys Leu Val Asp Val Glu Asp Leu Gly Tyr Phe Ala Lys 
                485                 490                 495     


Asn Asn Gln Gly Glu Leu Leu Leu Lys Gly Ala Pro Ile Cys Ser Glu 
            500                 505                 510         


Tyr Tyr Lys Asn Pro Glu Glu Thr Ala Ala Ala Phe Thr Asp Asp Gly 
        515                 520                 525             


Trp Phe Arg Thr Gly Asp Ile Ala Glu Trp Thr Pro Lys Gly Gln Ile 
    530                 535                 540                 


Lys Ile Ile Asp Arg Lys Lys Asn Leu Val Lys Thr Leu Asn Gly Glu 
545                 550                 555                 560 


Tyr Ile Ala Leu Glu Lys Leu Glu Ser Ile Tyr Arg Ser Asn Pro Tyr 
                565                 570                 575     


Val Gln Asn Ile Cys Val Tyr Ala Asp Glu Asn Lys Val Lys Pro Val 
            580                 585                 590         


Gly Ile Val Val Pro Asn Leu Gly His Leu Ser Lys Leu Ala Ile Glu 
        595                 600                 605             


Leu Gly Ile Met Val Pro Gly Glu Asp Val Glu Ser Tyr Ile His Glu 
    610                 615                 620                 


Lys Lys Leu Gln Asp Ala Val Cys Lys Asp Met Leu Ser Thr Ala Lys 
625                 630                 635                 640 


Ser Gln Gly Leu Asn Gly Ile Glu Leu Leu Cys Gly Ile Val Phe Phe 
                645                 650                 655     


Glu Glu Glu Trp Thr Pro Glu Asn Gly Leu Val Thr Ser Ala Gln Lys 
            660                 665                 670         


Leu Lys Arg Arg Asp Ile Leu Ala Ala Val Lys Pro Asp Val Glu Arg 
        675                 680                 685             


Val Tyr Lys Glu Asn Thr 
    690                 


<210>  201
<211>  6702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated acetyl-CoA carboxylase (ACC1) (S659A, S1157A)

<400>  201
atgagcgaag aaagcttatt cgagtcttct ccacagaaga tggagtacga aattacaaac       60

tactcagaaa gacatacaga acttccaggt catttcattg gcctcaatac agtagataaa      120

ctagaggagt ccccgttaag ggactttgtt aagagtcacg gtggtcacac ggtcatatcc      180

aagatcctga tagcaaataa tggtattgcc gccgtgaaag aaattagatc cgtcagaaaa      240

tgggcatacg agacgttcgg cgatgacaga accgtccaat tcgtcgccat ggccacccca      300

gaagatctgg aggccaacgc agaatatatc cgtatggccg atcaatacat tgaagtgcca      360

ggtggtacta ataataacaa ctacgctaac gtagacttga tcgtagacat cgccgaaaga      420

gcagacgtag acgccgtatg ggctggctgg ggtcacgcct ccgagaatcc actattgcct      480

gaaaaattgt cccagtctaa gaggaaagtc atctttattg ggcctccagg taacgccatg      540

aggtctttag gtgataaaat ctcctctacc attgtcgctc aaagtgctaa agtcccatgt      600

attccatggt ctggtaccgg tgttgacacc gttcacgtgg acgagaaaac cggtctggtc      660

tctgtcgacg atgacatcta tcaaaagggt tgttgtacct ctcctgaaga tggtttacaa      720

aaggccaagc gtattggttt tcctgtcatg attaaggcat ccgaaggtgg tggtggtaaa      780

ggtatcagac aagttgaacg tgaagaagat ttcatcgctt tataccacca ggcagccaac      840

gaaattccag gctcccccat tttcatcatg aagttggccg gtagagcgcg tcacttggaa      900

gttcaactgc tagcagatca gtacggtaca aatatttcct tgttcggtag agactgttcc      960

gttcagagac gtcatcaaaa aattatcgaa gaagcaccag ttacaattgc caaggctgaa     1020

acatttcacg agatggaaaa ggctgccgtc agactgggga aactagtcgg ttatgtctct     1080

gccggtaccg tggagtatct atattctcat gatgatggaa aattctactt tttagaattg     1140

aacccaagat tacaagtcga gcatccaaca acggaaatgg tctccggtgt taacttacct     1200

gcagctcaat tacaaatcgc tatgggtatc cctatgcata gaataagtga cattagaact     1260

ttatatggta tgaatcctca ttctgcctca gaaatcgatt tcgaattcaa aactcaagat     1320

gccaccaaga aacaaagaag acctattcca aagggtcatt gtaccgcttg tcgtatcaca     1380

tcagaagatc caaacgatgg attcaagcca tcgggtggta ctttgcatga actaaacttc     1440

cgttcttcct ctaatgtttg gggttacttc tccgtgggta acaatggtaa tattcactcc     1500

ttttcggact ctcagttcgg ccatattttt gcttttggtg aaaatagaca agcttccagg     1560

aaacacatgg ttgttgccct gaaggaattg tccattaggg gtgatttcag aactactgtg     1620

gaatacttga tcaaactttt ggaaactgaa gatttcgagg ataacactat taccaccggt     1680

tggttggacg atttgattac tcataaaatg accgctgaaa agcctgatcc aactcttgcc     1740

gtcatttgcg gtgccgctac aaaggctttc ttagcatctg aagaagcccg ccacaagtat     1800

atcgaatcct tacaaaaggg acaagttcta tctaaagacc tactgcaaac tatgttccct     1860

gtagatttta tccatgaggg taaaagatac aagttcaccg tagctaaatc cggtaatgac     1920

cgttacacat tatttatcaa tggttctaaa tgtgatatca tactgcgtca actatctgat     1980

ggtggtcttt tgattgccat aggcggtaaa tcgcatacca tctattggaa agaagaagtt     2040

gctgctacaa gattatccgt tgactctatg actactttgt tggaagttga aaacgatcca     2100

acccagttgc gtactccatc ccctggtaaa ttggttaaat tcttggtgga aaatggtgaa     2160

cacattatca agggccaacc atatgcagaa attgaagtta tgaaaatgca aatgcctttg     2220

gtttctcaag aaaatggtat cgtccagtta ttaaagcaac ctggttctac cattgttgca     2280

ggtgatatca tggctattat gactcttgac gatccatcca aggtcaagca cgctctacca     2340

tttgaaggta tgctgccaga ttttggttct ccagttatcg aaggaaccaa acctgcctat     2400

aaattcaagt cattagtgtc tactttggaa aacattttga agggttatga caaccaagtt     2460

attatgaacg cttccttgca acaattgata gaggttttga gaaatccaaa actgccttac     2520

tcagaatgga aactacacat ctctgcttta cattcaagat tgcctgctaa gctagatgaa     2580

caaatggaag agttagttgc acgttctttg agacgtggtg ctgttttccc agctagacaa     2640

ttaagtaaat tgattgatat ggccgtgaag aatcctgaat acaaccccga caaattgctg     2700

ggcgccgtcg tggaaccatt ggcggatatt gctcataagt actctaacgg gttagaagcc     2760

catgaacatt ctatatttgt ccatttcttg gaagaatatt acgaagttga aaagttattc     2820

aatggtccaa atgttcgtga ggaaaatatc attctgaaat tgcgtgatga aaaccctaaa     2880

gatctagata aagttgcgct aactgttttg tctcattcga aagtttcagc gaagaataac     2940

ctgatcctag ctatcttgaa acattatcaa ccattgtgca agttatcttc taaagtttct     3000

gccattttct ctactcctct acaacatatt gttgaactag aatctaaggc taccgctaag     3060

gtcgctctac aagcaagaga aattttgatt caaggcgctt taccttcggt caaggaaaga     3120

actgaacaaa ttgaacatat cttaaaatcc tctgttgtga aggttgccta tggctcatcc     3180

aatccaaagc gctctgaacc agatttgaat atcttgaagg acttgatcga ttctaattac     3240

gttgtgttcg atgttttact tcaattccta acccatcaag acccagttgt gactgctgca     3300

gctgctcaag tctatattcg tcgtgcttat cgtgcttaca ccataggaga tattagagtt     3360

cacgaaggtg tcacagttcc aattgttgaa tggaaattcc aactaccttc agctgcgttc     3420

tccacctttc caactgttaa atctaaaatg ggtatgaaca gggctgtttc tgtttcagat     3480

ttgtcatatg ttgcaaacag tcagtcatct ccgttaagag aaggtatttt gatggctgtg     3540

gatcatttag atgatgttga tgaaattttg tcacaaagtt tggaagttat tcctcgtcac     3600

caatcttctt ctaacggacc tgctcctgat cgttctggta gctccgcatc gttgagtaat     3660

gttgctaatg tttgtgttgc ttctacagaa ggtttcgaat ctgaagagga aattttggta     3720

aggttgagag aaattttgga tttgaataag caggaattaa tcaatgcttc tatccgtcgt     3780

atcacattta tgttcggttt taaagatggg tcttatccaa agtattatac ttttaacggt     3840

ccaaattata acgaaaatga aacaattcgt cacattgagc cggctttggc cttccaactg     3900

gaattaggaa gattgtccaa cttcaacatt aaaccaattt tcactgataa tagaaacatc     3960

catgtctacg aagctgttag taagacttct ccattggata agagattctt tacaagaggt     4020

attattagaa cgggtcatat ccgtgatgac atttctattc aagaatatct gacttctgaa     4080

gctaacagat tgatgagtga tatattggat aatttagaag tcaccgacac ttcaaattct     4140

gatttgaatc atatcttcat caacttcatt gcggtgtttg atatctctcc agaagatgtc     4200

gaagccgcct tcggtggttt cttagaaaga tttggtaaga gattgttgag attgcgtgtt     4260

tcttctgccg aaattagaat catcatcaaa gatcctcaaa caggtgcccc agtaccattg     4320

cgtgccttga tcaataacgt ttctggttat gttatcaaaa cagaaatgta caccgaagtc     4380

aagaacgcaa aaggtgaatg ggtatttaag tctttgggta aacctggatc catgcattta     4440

agacctattg ctactcctta ccctgttaag gaatggttgc aaccaaaacg ttataaggca     4500

cacttgatgg gtaccacata tgtctatgac ttcccagaat tattccgcca agcatcgtca     4560

tcccaatgga aaaatttctc tgcagatgtt aagttaacag atgatttctt tatttccaac     4620

gagttgattg aagatgaaaa cggcgaatta actgaggtgg aaagagaacc tggtgccaac     4680

gctattggta tggttgcctt taagattact gtaaagactc ctgaatatcc aagaggccgt     4740

caatttgttg ttgttgctaa cgatatcaca ttcaagatcg gttcctttgg tccacaagaa     4800

gacgaattct tcaataaggt tactgaatat gctagaaagc gtggtatccc aagaatttac     4860

ttggctgcaa actcaggtgc cagaattggt atggctgaag agattgttcc actatttcaa     4920

gttgcatgga atgatgctgc caatccggac aagggcttcc aatacttata cttaacaagt     4980

gaaggtatgg aaactttaaa gaaatttgac aaagaaaatt ctgttctcac tgaacgtact     5040

gttataaacg gtgaagaaag atttgtcatc aagacaatta ttggttctga agatgggtta     5100

ggtgtcgaat gtctacgtgg atctggttta attgctggtg caacgtcaag ggcttaccac     5160

gatatcttca ctatcacctt agtcacttgt agatccgtcg gtatcggtgc ttatttggtt     5220

cgtttgggtc aaagagctat tcaggtcgaa ggccagccaa ttattttaac tggtgctcct     5280

gcaatcaaca aaatgctggg tagagaagtt tatacttcta acttacaatt gggtggtact     5340

caaatcatgt ataacaacgg tgtttcacat ttgactgctg ttgacgattt agctggtgta     5400

gagaagattg ttgaatggat gtcttatgtt ccagccaagc gtaatatgcc agttcctatc     5460

ttggaaacta aagacacatg ggatagacca gttgatttca ctccaactaa tgatgaaact     5520

tacgatgtaa gatggatgat tgaaggtcgt gagactgaaa gtggatttga atatggtttg     5580

tttgataaag ggtctttctt tgaaactttg tcaggatggg ccaaaggtgt tgtcgttggt     5640

agagcccgtc ttggtggtat tccactgggt gttattggtg ttgaaacaag aactgtcgag     5700

aacttgattc ctgctgatcc agctaatcca aatagtgctg aaacattaat tcaagaacct     5760

ggtcaagttt ggcatccaaa ctccgccttc aagactgctc aagctatcaa tgactttaac     5820

aacggtgaac aattgccaat gatgattttg gccaactgga gaggtttctc tggtggtcaa     5880

cgtgatatgt tcaacgaagt cttgaagtat ggttcgttta ttgttgacgc attggtggat     5940

tacaaacaac caattattat ctatatccca cctaccggtg aactaagagg tggttcatgg     6000

gttgttgtcg atccaactat caacgctgac caaatggaaa tgtatgccga cgtcaacgct     6060

agagctggtg ttttggaacc acaaggtatg gttggtatca agttccgtag agaaaaattg     6120

ctggacacca tgaacagatt ggatgacaag tacagagaat tgagatctca attatccaac     6180

aagagtttgg ctccagaagt acatcagcaa atatccaagc aattagctga tcgtgagaga     6240

gaactattgc caatttacgg acaaatcagt cttcaatttg ctgatttgca cgataggtct     6300

tcacgtatgg tggccaaggg tgttatttct aaggaactgg aatggaccga ggcacgtcgt     6360

ttcttcttct ggagattgag aagaagattg aacgaagaat atttgattaa aaggttgagc     6420

catcaggtag gcgaagcatc aagattagaa aagatcgcaa gaattagatc gtggtaccct     6480

gcttcagtgg accatgaaga tgataggcaa gtcgcaacat ggattgaaga aaactacaaa     6540

actttggacg ataaactaaa gggtttgaaa ttagagtcat tcgctcaaga cttagctaaa     6600

aagatcagaa gcgaccatga caatgctatt gatggattat ctgaagttat caagatgtta     6660

tctaccgatg ataaagaaaa attgttgaag actttgaaat aa                        6702


<210>  202
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Ag_GPPS_Ntrunc

<400>  202
atgtcttttg acttcaataa gtatatggat tctaaggcta tgaccgtcaa cgaggctttg       60

aataaagcca tcccattgcg ttacccacaa aagatctacg aatctatgag atattctttg      120

ttagctggtg gtaagagagt ccgtccagtt ttgtgtatcg ccgcttgtga attagtcggt      180

ggtactgagg agttagctat tccaaccgcc tgtgccatcg aaatgatcca caccatgtct      240

ttgatgcacg atgatttgcc atgtatcgac aacgatgact tgagacgtgg taaacctacc      300

aatcataaga ttttcggtga agatactgct gttactgccg gtaacgcttt acactcttac      360

gccttcgaac atattgctgt ttctacttcc aagactgttg gtgctgatag aattttgaga      420

atggtttctg aattaggtcg tgctactggt tccgaaggtg ttatgggtgg tcaaatggtc      480

gatattgctt ctgaaggtga cccttccatt gatttgcaaa ctttagaatg gatccacatc      540

cacaagactg ctatgttatt agaatgttct gttgtctgtg gtgccatcat cggtggtgct      600

tctgaaattg ttattgagag agccagacgt tatgctcgtt gtgtcggttt attgtttcaa      660

gttgttgacg acattttaga tgttaccaaa tcttctgacg aattgggtaa aactgctggt      720

aaagatttaa tctccgataa agccacctac cctaagttga tgggtttgga gaaggccaaa      780

gagttttccg atgaattatt aaacagagct aaaggtgaat tgtcttgctt cgatccagtt      840

aaggctgccc cattgttagg tttggctgac tacgttgcct tcagacaaaa ctaa            894


<210>  203
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranylgeranyl pyrophosphate synthase Ag_GPPS_Ntrunc

<400>  203

Met Ser Phe Asp Phe Asn Lys Tyr Met Asp Ser Lys Ala Met Thr Val 
1               5                   10                  15      


Asn Glu Ala Leu Asn Lys Ala Ile Pro Leu Arg Tyr Pro Gln Lys Ile 
            20                  25                  30          


Tyr Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg 
        35                  40                  45              


Pro Val Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Thr Glu Glu 
    50                  55                  60                  


Leu Ala Ile Pro Thr Ala Cys Ala Ile Glu Met Ile His Thr Met Ser 
65                  70                  75                  80  


Leu Met His Asp Asp Leu Pro Cys Ile Asp Asn Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Lys Pro Thr Asn His Lys Ile Phe Gly Glu Asp Thr Ala Val Thr 
            100                 105                 110         


Ala Gly Asn Ala Leu His Ser Tyr Ala Phe Glu His Ile Ala Val Ser 
        115                 120                 125             


Thr Ser Lys Thr Val Gly Ala Asp Arg Ile Leu Arg Met Val Ser Glu 
    130                 135                 140                 


Leu Gly Arg Ala Thr Gly Ser Glu Gly Val Met Gly Gly Gln Met Val 
145                 150                 155                 160 


Asp Ile Ala Ser Glu Gly Asp Pro Ser Ile Asp Leu Gln Thr Leu Glu 
                165                 170                 175     


Trp Ile His Ile His Lys Thr Ala Met Leu Leu Glu Cys Ser Val Val 
            180                 185                 190         


Cys Gly Ala Ile Ile Gly Gly Ala Ser Glu Ile Val Ile Glu Arg Ala 
        195                 200                 205             


Arg Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Thr Lys Ser Ser Asp Glu Leu Gly Lys Thr Ala Gly 
225                 230                 235                 240 


Lys Asp Leu Ile Ser Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu 
                245                 250                 255     


Glu Lys Ala Lys Glu Phe Ser Asp Glu Leu Leu Asn Arg Ala Lys Gly 
            260                 265                 270         


Glu Leu Ser Cys Phe Asp Pro Val Lys Ala Ala Pro Leu Leu Gly Leu 
        275                 280                 285             


Ala Asp Tyr Val Ala Phe Arg Gln Asn 
    290                 295         


<210>  204
<211>  1356
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  204
ttatttatca agataagttt ccggatcttt ttctttccta acaccccagt cagcctgagt       60

tacatccagc cattgaacct tagaaaatct tttgtcatca gcggtttgag ccctaagatc      120

aacatcttgc ttagcaatca ctgcaatggc gtcataacca ccagcaccag gtattaagca      180

agtaagaact ccttttaagg tctggcaatc atccaataag ctagtttgta cgggaggttc      240

gatatcggca ccagattctt tagttatttt tctaaaggaa cgtctaattg tggcaactgc      300

atctctaact tctgtgatct caggatactt ttgacaggta cagtcattcc tctcaagaga      360

ctcaaatatc tgatcgctgt aatcgtcatg agtctcgtgt aagcgatcta gtttagatag      420

tccatccata aatctagaat ttgcatgatc gagttctgta tatattttca agctttccgg      480

catatgcgaa tcataccaat tttttacctt ctggaccagt tttactgttt ctgaaccatt      540

cttaatatcg cccatccata aagttaatcc cgaaggtaaa tggttacttt taatcgttat      600

attccagtct tcttcattaa ccaaatgcgc cagtttactg ccgtaagtag cacttccaat      660

atctggcaaa ttagagatta atgcgggtgg gaatcttcta tatctgatag atccatatgc      720

tgccgccgct acatcaaacc cgcttccaat tttaccctga gcttgacaat gagcaacttg      780

tgataaatta tgaataactt ctctatattt gtctacatta ttttccaggt ccgatacaaa      840

aaaggaggcc aaagctgtag ttaaaactgt gactaaacct gccgaggagc ccagccctgt      900

tttgggaact tcttcaattc tgtgcgaatg aaaactcaat cttctgttgc cacgatgttc      960

ggtaacgctg tcctcctgag aatggtaggc atcatcagag aaaatatcaa taacgaacaa     1020

gtttctattg cagtagtcgt ccatgttagg cttaaagtag ctaaatacgt tagcgataac     1080

tttttcaatg aaagggttct tagatccgcc tatcgaaaca ggaatgaagc cagttttagg     1140

acttatatgg tacagccact ccccatcttt aaattgttta cttttcacac gcacttcaaa     1200

cttatcagac tcttgcaatg aaccgtaagg atgggctaca gcatgcattc ttgccgataa     1260

tccgactaca aatgcttcat atttcggatc taaaactaaa tatccaccag ctagtaacgc     1320

tttccctggg gcactgaagg ctctcaactc tgacat                               1356


<210>  205
<211>  451
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  205

Met Ser Glu Leu Arg Ala Phe Ser Ala Pro Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


Gly Gly Tyr Leu Val Leu Asp Pro Lys Tyr Glu Ala Phe Val Val Gly 
            20                  25                  30          


Leu Ser Ala Arg Met His Ala Val Ala His Pro Tyr Gly Ser Leu Gln 
        35                  40                  45              


Glu Ser Asp Lys Phe Glu Val Arg Val Lys Ser Lys Gln Phe Lys Asp 
    50                  55                  60                  


Gly Glu Trp Leu Tyr His Ile Ser Pro Lys Thr Gly Phe Ile Pro Val 
65                  70                  75                  80  


Ser Ile Gly Gly Ser Lys Asn Pro Phe Ile Glu Lys Val Ile Ala Asn 
                85                  90                  95      


Val Phe Ser Tyr Phe Lys Pro Asn Met Asp Asp Tyr Cys Asn Arg Asn 
            100                 105                 110         


Leu Phe Val Ile Asp Ile Phe Ser Asp Asp Ala Tyr His Ser Gln Glu 
        115                 120                 125             


Asp Ser Val Thr Glu His Arg Gly Asn Arg Arg Leu Ser Phe His Ser 
    130                 135                 140                 


His Arg Ile Glu Glu Val Pro Lys Thr Gly Leu Gly Ser Ser Ala Gly 
145                 150                 155                 160 


Leu Val Thr Val Leu Thr Thr Ala Leu Ala Ser Phe Phe Val Ser Asp 
                165                 170                 175     


Leu Glu Asn Asn Val Asp Lys Tyr Arg Glu Val Ile His Asn Leu Ser 
            180                 185                 190         


Gln Val Ala His Cys Gln Ala Gln Gly Lys Ile Gly Ser Gly Phe Asp 
        195                 200                 205             


Val Ala Ala Ala Ala Tyr Gly Ser Ile Arg Tyr Arg Arg Phe Pro Pro 
    210                 215                 220                 


Ala Leu Ile Ser Asn Leu Pro Asp Ile Gly Ser Ala Thr Tyr Gly Ser 
225                 230                 235                 240 


Lys Leu Ala His Leu Val Asn Glu Glu Asp Trp Asn Ile Thr Ile Lys 
                245                 250                 255     


Ser Asn His Leu Pro Ser Gly Leu Thr Leu Trp Met Gly Asp Ile Lys 
            260                 265                 270         


Asn Gly Ser Glu Thr Val Lys Leu Val Gln Lys Val Lys Asn Trp Tyr 
        275                 280                 285             


Asp Ser His Met Pro Glu Ser Leu Lys Ile Tyr Thr Glu Leu Asp His 
    290                 295                 300                 


Ala Asn Ser Arg Phe Met Asp Gly Leu Ser Lys Leu Asp Arg Leu His 
305                 310                 315                 320 


Glu Thr His Asp Asp Tyr Ser Asp Gln Ile Phe Glu Ser Leu Glu Arg 
                325                 330                 335     


Asn Asp Cys Thr Cys Gln Lys Tyr Pro Glu Ile Thr Glu Val Arg Asp 
            340                 345                 350         


Ala Val Ala Thr Ile Arg Arg Ser Phe Arg Lys Ile Thr Lys Glu Ser 
        355                 360                 365             


Gly Ala Asp Ile Glu Pro Pro Val Gln Thr Ser Leu Leu Asp Asp Cys 
    370                 375                 380                 


Gln Thr Leu Lys Gly Val Leu Thr Cys Leu Ile Pro Gly Ala Gly Gly 
385                 390                 395                 400 


Tyr Asp Ala Ile Ala Val Ile Ala Lys Gln Asp Val Asp Leu Arg Ala 
                405                 410                 415     


Gln Thr Ala Asp Asp Lys Arg Phe Ser Lys Val Gln Trp Leu Asp Val 
            420                 425                 430         


Thr Gln Ala Asp Trp Gly Val Arg Lys Glu Lys Asp Pro Glu Thr Tyr 
        435                 440                 445             


Leu Asp Lys 
    450     


<210>  206
<211>  1332
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  206
atgtcattac cgttcttaac ttctgcaccg ggaaaggtta ttatttttgg tgaacactct       60

gctgtgtaca acaagcctgc cgtcgctgct agtgtgtctg cgttgagaac ctacctgcta      120

ataagcgagt catctgcacc agatactatt gaattggact tcccggacat tagctttaat      180

cataagtggt ccatcaatga tttcaatgcc atcaccgagg atcaagtaaa ctcccaaaaa      240

ttggccaagg ctcaacaagc caccgatggc ttgtctcagg aactcgttag tcttttggat      300

ccgttgttag ctcaactatc cgaatccttc cactaccatg cagcgttttg tttcctgtat      360

atgtttgttt gcctatgccc ccatgccaag aatattaagt tttctttaaa gtctacttta      420

cccatcggtg ctgggttggg ctcaagcgcc tctatttctg tatcactggc cttagctatg      480

gcctacttgg gggggttaat aggatctaat gacttggaaa agctgtcaga aaacgataag      540

catatagtga atcaatgggc cttcataggt gaaaagtgta ttcacggtac cccttcagga      600

atagataacg ctgtggccac ttatggtaat gccctgctat ttgaaaaaga ctcacataat      660

ggaacaataa acacaaacaa ttttaagttc ttagatgatt tcccagccat tccaatgatc      720

ctaacctata ctagaattcc aaggtctaca aaagatcttg ttgctcgcgt tcgtgtgttg      780

gtcaccgaga aatttcctga agttatgaag ccaattctag atgccatggg tgaatgtgcc      840

ctacaaggct tagagatcat gactaagtta agtaaatgta aaggcaccga tgacgaggct      900

gtagaaacta ataatgaact gtatgaacaa ctattggaat tgataagaat aaatcatgga      960

ctgcttgtct caatcggtgt ttctcatcct ggattagaac ttattaaaaa tctgagcgat     1020

gatttgagaa ttggctccac aaaacttacc ggtgctggtg gcggcggttg ctctttgact     1080

ttgttacgaa gagacattac tcaagagcaa attgacagtt tcaaaaagaa attgcaagat     1140

gattttagtt acgagacatt tgaaacagac ttgggtggga ctggctgctg tttgttaagc     1200

gcaaaaaatt tgaataaaga tcttaaaatc aaatccctag tattccaatt atttgaaaat     1260

aaaactacca caaagcaaca aattgacgat ctattattgc caggaaacac gaatttacca     1320

tggacttcat aa                                                         1332


<210>  207
<211>  2233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated acetyl-CoA carboxylase (ACC1) (S659A, S1157A)

<400>  207

Met Ser Glu Glu Ser Leu Phe Glu Ser Ser Pro Gln Lys Met Glu Tyr 
1               5                   10                  15      


Glu Ile Thr Asn Tyr Ser Glu Arg His Thr Glu Leu Pro Gly His Phe 
            20                  25                  30          


Ile Gly Leu Asn Thr Val Asp Lys Leu Glu Glu Ser Pro Leu Arg Asp 
        35                  40                  45              


Phe Val Lys Ser His Gly Gly His Thr Val Ile Ser Lys Ile Leu Ile 
    50                  55                  60                  


Ala Asn Asn Gly Ile Ala Ala Val Lys Glu Ile Arg Ser Val Arg Lys 
65                  70                  75                  80  


Trp Ala Tyr Glu Thr Phe Gly Asp Asp Arg Thr Val Gln Phe Val Ala 
                85                  90                  95      


Met Ala Thr Pro Glu Asp Leu Glu Ala Asn Ala Glu Tyr Ile Arg Met 
            100                 105                 110         


Ala Asp Gln Tyr Ile Glu Val Pro Gly Gly Thr Asn Asn Asn Asn Tyr 
        115                 120                 125             


Ala Asn Val Asp Leu Ile Val Asp Ile Ala Glu Arg Ala Asp Val Asp 
    130                 135                 140                 


Ala Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Lys Leu Ser Gln Ser Lys Arg Lys Val Ile Phe Ile Gly Pro Pro 
                165                 170                 175     


Gly Asn Ala Met Arg Ser Leu Gly Asp Lys Ile Ser Ser Thr Ile Val 
            180                 185                 190         


Ala Gln Ser Ala Lys Val Pro Cys Ile Pro Trp Ser Gly Thr Gly Val 
        195                 200                 205             


Asp Thr Val His Val Asp Glu Lys Thr Gly Leu Val Ser Val Asp Asp 
    210                 215                 220                 


Asp Ile Tyr Gln Lys Gly Cys Cys Thr Ser Pro Glu Asp Gly Leu Gln 
225                 230                 235                 240 


Lys Ala Lys Arg Ile Gly Phe Pro Val Met Ile Lys Ala Ser Glu Gly 
                245                 250                 255     


Gly Gly Gly Lys Gly Ile Arg Gln Val Glu Arg Glu Glu Asp Phe Ile 
            260                 265                 270         


Ala Leu Tyr His Gln Ala Ala Asn Glu Ile Pro Gly Ser Pro Ile Phe 
        275                 280                 285             


Ile Met Lys Leu Ala Gly Arg Ala Arg His Leu Glu Val Gln Leu Leu 
    290                 295                 300                 


Ala Asp Gln Tyr Gly Thr Asn Ile Ser Leu Phe Gly Arg Asp Cys Ser 
305                 310                 315                 320 


Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Val Thr Ile 
                325                 330                 335     


Ala Lys Ala Glu Thr Phe His Glu Met Glu Lys Ala Ala Val Arg Leu 
            340                 345                 350         


Gly Lys Leu Val Gly Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr 
        355                 360                 365             


Ser His Asp Asp Gly Lys Phe Tyr Phe Leu Glu Leu Asn Pro Arg Leu 
    370                 375                 380                 


Gln Val Glu His Pro Thr Thr Glu Met Val Ser Gly Val Asn Leu Pro 
385                 390                 395                 400 


Ala Ala Gln Leu Gln Ile Ala Met Gly Ile Pro Met His Arg Ile Ser 
                405                 410                 415     


Asp Ile Arg Thr Leu Tyr Gly Met Asn Pro His Ser Ala Ser Glu Ile 
            420                 425                 430         


Asp Phe Glu Phe Lys Thr Gln Asp Ala Thr Lys Lys Gln Arg Arg Pro 
        435                 440                 445             


Ile Pro Lys Gly His Cys Thr Ala Cys Arg Ile Thr Ser Glu Asp Pro 
    450                 455                 460                 


Asn Asp Gly Phe Lys Pro Ser Gly Gly Thr Leu His Glu Leu Asn Phe 
465                 470                 475                 480 


Arg Ser Ser Ser Asn Val Trp Gly Tyr Phe Ser Val Gly Asn Asn Gly 
                485                 490                 495     


Asn Ile His Ser Phe Ser Asp Ser Gln Phe Gly His Ile Phe Ala Phe 
            500                 505                 510         


Gly Glu Asn Arg Gln Ala Ser Arg Lys His Met Val Val Ala Leu Lys 
        515                 520                 525             


Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr Leu Ile 
    530                 535                 540                 


Lys Leu Leu Glu Thr Glu Asp Phe Glu Asp Asn Thr Ile Thr Thr Gly 
545                 550                 555                 560 


Trp Leu Asp Asp Leu Ile Thr His Lys Met Thr Ala Glu Lys Pro Asp 
                565                 570                 575     


Pro Thr Leu Ala Val Ile Cys Gly Ala Ala Thr Lys Ala Phe Leu Ala 
            580                 585                 590         


Ser Glu Glu Ala Arg His Lys Tyr Ile Glu Ser Leu Gln Lys Gly Gln 
        595                 600                 605             


Val Leu Ser Lys Asp Leu Leu Gln Thr Met Phe Pro Val Asp Phe Ile 
    610                 615                 620                 


His Glu Gly Lys Arg Tyr Lys Phe Thr Val Ala Lys Ser Gly Asn Asp 
625                 630                 635                 640 


Arg Tyr Thr Leu Phe Ile Asn Gly Ser Lys Cys Asp Ile Ile Leu Arg 
                645                 650                 655     


Gln Leu Ser Asp Gly Gly Leu Leu Ile Ala Ile Gly Gly Lys Ser His 
            660                 665                 670         


Thr Ile Tyr Trp Lys Glu Glu Val Ala Ala Thr Arg Leu Ser Val Asp 
        675                 680                 685             


Ser Met Thr Thr Leu Leu Glu Val Glu Asn Asp Pro Thr Gln Leu Arg 
    690                 695                 700                 


Thr Pro Ser Pro Gly Lys Leu Val Lys Phe Leu Val Glu Asn Gly Glu 
705                 710                 715                 720 


His Ile Ile Lys Gly Gln Pro Tyr Ala Glu Ile Glu Val Met Lys Met 
                725                 730                 735     


Gln Met Pro Leu Val Ser Gln Glu Asn Gly Ile Val Gln Leu Leu Lys 
            740                 745                 750         


Gln Pro Gly Ser Thr Ile Val Ala Gly Asp Ile Met Ala Ile Met Thr 
        755                 760                 765             


Leu Asp Asp Pro Ser Lys Val Lys His Ala Leu Pro Phe Glu Gly Met 
    770                 775                 780                 


Leu Pro Asp Phe Gly Ser Pro Val Ile Glu Gly Thr Lys Pro Ala Tyr 
785                 790                 795                 800 


Lys Phe Lys Ser Leu Val Ser Thr Leu Glu Asn Ile Leu Lys Gly Tyr 
                805                 810                 815     


Asp Asn Gln Val Ile Met Asn Ala Ser Leu Gln Gln Leu Ile Glu Val 
            820                 825                 830         


Leu Arg Asn Pro Lys Leu Pro Tyr Ser Glu Trp Lys Leu His Ile Ser 
        835                 840                 845             


Ala Leu His Ser Arg Leu Pro Ala Lys Leu Asp Glu Gln Met Glu Glu 
    850                 855                 860                 


Leu Val Ala Arg Ser Leu Arg Arg Gly Ala Val Phe Pro Ala Arg Gln 
865                 870                 875                 880 


Leu Ser Lys Leu Ile Asp Met Ala Val Lys Asn Pro Glu Tyr Asn Pro 
                885                 890                 895     


Asp Lys Leu Leu Gly Ala Val Val Glu Pro Leu Ala Asp Ile Ala His 
            900                 905                 910         


Lys Tyr Ser Asn Gly Leu Glu Ala His Glu His Ser Ile Phe Val His 
        915                 920                 925             


Phe Leu Glu Glu Tyr Tyr Glu Val Glu Lys Leu Phe Asn Gly Pro Asn 
    930                 935                 940                 


Val Arg Glu Glu Asn Ile Ile Leu Lys Leu Arg Asp Glu Asn Pro Lys 
945                 950                 955                 960 


Asp Leu Asp Lys Val Ala Leu Thr Val Leu Ser His Ser Lys Val Ser 
                965                 970                 975     


Ala Lys Asn Asn Leu Ile Leu Ala Ile Leu Lys His Tyr Gln Pro Leu 
            980                 985                 990         


Cys Lys Leu Ser Ser Lys Val Ser  Ala Ile Phe Ser Thr  Pro Leu Gln 
        995                 1000                 1005             


His Ile  Val Glu Leu Glu Ser  Lys Ala Thr Ala Lys  Val Ala Leu 
    1010                 1015                 1020             


Gln Ala  Arg Glu Ile Leu Ile  Gln Gly Ala Leu Pro  Ser Val Lys 
    1025                 1030                 1035             


Glu Arg  Thr Glu Gln Ile Glu  His Ile Leu Lys Ser  Ser Val Val 
    1040                 1045                 1050             


Lys Val  Ala Tyr Gly Ser Ser  Asn Pro Lys Arg Ser  Glu Pro Asp 
    1055                 1060                 1065             


Leu Asn  Ile Leu Lys Asp Leu  Ile Asp Ser Asn Tyr  Val Val Phe 
    1070                 1075                 1080             


Asp Val  Leu Leu Gln Phe Leu  Thr His Gln Asp Pro  Val Val Thr 
    1085                 1090                 1095             


Ala Ala  Ala Ala Gln Val Tyr  Ile Arg Arg Ala Tyr  Arg Ala Tyr 
    1100                 1105                 1110             


Thr Ile  Gly Asp Ile Arg Val  His Glu Gly Val Thr  Val Pro Ile 
    1115                 1120                 1125             


Val Glu  Trp Lys Phe Gln Leu  Pro Ser Ala Ala Phe  Ser Thr Phe 
    1130                 1135                 1140             


Pro Thr  Val Lys Ser Lys Met  Gly Met Asn Arg Ala  Val Ser Val 
    1145                 1150                 1155             


Ser Asp  Leu Ser Tyr Val Ala  Asn Ser Gln Ser Ser  Pro Leu Arg 
    1160                 1165                 1170             


Glu Gly  Ile Leu Met Ala Val  Asp His Leu Asp Asp  Val Asp Glu 
    1175                 1180                 1185             


Ile Leu  Ser Gln Ser Leu Glu  Val Ile Pro Arg His  Gln Ser Ser 
    1190                 1195                 1200             


Ser Asn  Gly Pro Ala Pro Asp  Arg Ser Gly Ser Ser  Ala Ser Leu 
    1205                 1210                 1215             


Ser Asn  Val Ala Asn Val Cys  Val Ala Ser Thr Glu  Gly Phe Glu 
    1220                 1225                 1230             


Ser Glu  Glu Glu Ile Leu Val  Arg Leu Arg Glu Ile  Leu Asp Leu 
    1235                 1240                 1245             


Asn Lys  Gln Glu Leu Ile Asn  Ala Ser Ile Arg Arg  Ile Thr Phe 
    1250                 1255                 1260             


Met Phe  Gly Phe Lys Asp Gly  Ser Tyr Pro Lys Tyr  Tyr Thr Phe 
    1265                 1270                 1275             


Asn Gly  Pro Asn Tyr Asn Glu  Asn Glu Thr Ile Arg  His Ile Glu 
    1280                 1285                 1290             


Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Gly Arg Leu  Ser Asn Phe 
    1295                 1300                 1305             


Asn Ile  Lys Pro Ile Phe Thr  Asp Asn Arg Asn Ile  His Val Tyr 
    1310                 1315                 1320             


Glu Ala  Val Ser Lys Thr Ser  Pro Leu Asp Lys Arg  Phe Phe Thr 
    1325                 1330                 1335             


Arg Gly  Ile Ile Arg Thr Gly  His Ile Arg Asp Asp  Ile Ser Ile 
    1340                 1345                 1350             


Gln Glu  Tyr Leu Thr Ser Glu  Ala Asn Arg Leu Met  Ser Asp Ile 
    1355                 1360                 1365             


Leu Asp  Asn Leu Glu Val Thr  Asp Thr Ser Asn Ser  Asp Leu Asn 
    1370                 1375                 1380             


His Ile  Phe Ile Asn Phe Ile  Ala Val Phe Asp Ile  Ser Pro Glu 
    1385                 1390                 1395             


Asp Val  Glu Ala Ala Phe Gly  Gly Phe Leu Glu Arg  Phe Gly Lys 
    1400                 1405                 1410             


Arg Leu  Leu Arg Leu Arg Val  Ser Ser Ala Glu Ile  Arg Ile Ile 
    1415                 1420                 1425             


Ile Lys  Asp Pro Gln Thr Gly  Ala Pro Val Pro Leu  Arg Ala Leu 
    1430                 1435                 1440             


Ile Asn  Asn Val Ser Gly Tyr  Val Ile Lys Thr Glu  Met Tyr Thr 
    1445                 1450                 1455             


Glu Val  Lys Asn Ala Lys Gly  Glu Trp Val Phe Lys  Ser Leu Gly 
    1460                 1465                 1470             


Lys Pro  Gly Ser Met His Leu  Arg Pro Ile Ala Thr  Pro Tyr Pro 
    1475                 1480                 1485             


Val Lys  Glu Trp Leu Gln Pro  Lys Arg Tyr Lys Ala  His Leu Met 
    1490                 1495                 1500             


Gly Thr  Thr Tyr Val Tyr Asp  Phe Pro Glu Leu Phe  Arg Gln Ala 
    1505                 1510                 1515             


Ser Ser  Ser Gln Trp Lys Asn  Phe Ser Ala Asp Val  Lys Leu Thr 
    1520                 1525                 1530             


Asp Asp  Phe Phe Ile Ser Asn  Glu Leu Ile Glu Asp  Glu Asn Gly 
    1535                 1540                 1545             


Glu Leu  Thr Glu Val Glu Arg  Glu Pro Gly Ala Asn  Ala Ile Gly 
    1550                 1555                 1560             


Met Val  Ala Phe Lys Ile Thr  Val Lys Thr Pro Glu  Tyr Pro Arg 
    1565                 1570                 1575             


Gly Arg  Gln Phe Val Val Val  Ala Asn Asp Ile Thr  Phe Lys Ile 
    1580                 1585                 1590             


Gly Ser  Phe Gly Pro Gln Glu  Asp Glu Phe Phe Asn  Lys Val Thr 
    1595                 1600                 1605             


Glu Tyr  Ala Arg Lys Arg Gly  Ile Pro Arg Ile Tyr  Leu Ala Ala 
    1610                 1615                 1620             


Asn Ser  Gly Ala Arg Ile Gly  Met Ala Glu Glu Ile  Val Pro Leu 
    1625                 1630                 1635             


Phe Gln  Val Ala Trp Asn Asp  Ala Ala Asn Pro Asp  Lys Gly Phe 
    1640                 1645                 1650             


Gln Tyr  Leu Tyr Leu Thr Ser  Glu Gly Met Glu Thr  Leu Lys Lys 
    1655                 1660                 1665             


Phe Asp  Lys Glu Asn Ser Val  Leu Thr Glu Arg Thr  Val Ile Asn 
    1670                 1675                 1680             


Gly Glu  Glu Arg Phe Val Ile  Lys Thr Ile Ile Gly  Ser Glu Asp 
    1685                 1690                 1695             


Gly Leu  Gly Val Glu Cys Leu  Arg Gly Ser Gly Leu  Ile Ala Gly 
    1700                 1705                 1710             


Ala Thr  Ser Arg Ala Tyr His  Asp Ile Phe Thr Ile  Thr Leu Val 
    1715                 1720                 1725             


Thr Cys  Arg Ser Val Gly Ile  Gly Ala Tyr Leu Val  Arg Leu Gly 
    1730                 1735                 1740             


Gln Arg  Ala Ile Gln Val Glu  Gly Gln Pro Ile Ile  Leu Thr Gly 
    1745                 1750                 1755             


Ala Pro  Ala Ile Asn Lys Met  Leu Gly Arg Glu Val  Tyr Thr Ser 
    1760                 1765                 1770             


Asn Leu  Gln Leu Gly Gly Thr  Gln Ile Met Tyr Asn  Asn Gly Val 
    1775                 1780                 1785             


Ser His  Leu Thr Ala Val Asp  Asp Leu Ala Gly Val  Glu Lys Ile 
    1790                 1795                 1800             


Val Glu  Trp Met Ser Tyr Val  Pro Ala Lys Arg Asn  Met Pro Val 
    1805                 1810                 1815             


Pro Ile  Leu Glu Thr Lys Asp  Thr Trp Asp Arg Pro  Val Asp Phe 
    1820                 1825                 1830             


Thr Pro  Thr Asn Asp Glu Thr  Tyr Asp Val Arg Trp  Met Ile Glu 
    1835                 1840                 1845             


Gly Arg  Glu Thr Glu Ser Gly  Phe Glu Tyr Gly Leu  Phe Asp Lys 
    1850                 1855                 1860             


Gly Ser  Phe Phe Glu Thr Leu  Ser Gly Trp Ala Lys  Gly Val Val 
    1865                 1870                 1875             


Val Gly  Arg Ala Arg Leu Gly  Gly Ile Pro Leu Gly  Val Ile Gly 
    1880                 1885                 1890             


Val Glu  Thr Arg Thr Val Glu  Asn Leu Ile Pro Ala  Asp Pro Ala 
    1895                 1900                 1905             


Asn Pro  Asn Ser Ala Glu Thr  Leu Ile Gln Glu Pro  Gly Gln Val 
    1910                 1915                 1920             


Trp His  Pro Asn Ser Ala Phe  Lys Thr Ala Gln Ala  Ile Asn Asp 
    1925                 1930                 1935             


Phe Asn  Asn Gly Glu Gln Leu  Pro Met Met Ile Leu  Ala Asn Trp 
    1940                 1945                 1950             


Arg Gly  Phe Ser Gly Gly Gln  Arg Asp Met Phe Asn  Glu Val Leu 
    1955                 1960                 1965             


Lys Tyr  Gly Ser Phe Ile Val  Asp Ala Leu Val Asp  Tyr Lys Gln 
    1970                 1975                 1980             


Pro Ile  Ile Ile Tyr Ile Pro  Pro Thr Gly Glu Leu  Arg Gly Gly 
    1985                 1990                 1995             


Ser Trp  Val Val Val Asp Pro  Thr Ile Asn Ala Asp  Gln Met Glu 
    2000                 2005                 2010             


Met Tyr  Ala Asp Val Asn Ala  Arg Ala Gly Val Leu  Glu Pro Gln 
    2015                 2020                 2025             


Gly Met  Val Gly Ile Lys Phe  Arg Arg Glu Lys Leu  Leu Asp Thr 
    2030                 2035                 2040             


Met Asn  Arg Leu Asp Asp Lys  Tyr Arg Glu Leu Arg  Ser Gln Leu 
    2045                 2050                 2055             


Ser Asn  Lys Ser Leu Ala Pro  Glu Val His Gln Gln  Ile Ser Lys 
    2060                 2065                 2070             


Gln Leu  Ala Asp Arg Glu Arg  Glu Leu Leu Pro Ile  Tyr Gly Gln 
    2075                 2080                 2085             


Ile Ser  Leu Gln Phe Ala Asp  Leu His Asp Arg Ser  Ser Arg Met 
    2090                 2095                 2100             


Val Ala  Lys Gly Val Ile Ser  Lys Glu Leu Glu Trp  Thr Glu Ala 
    2105                 2110                 2115             


Arg Arg  Phe Phe Phe Trp Arg  Leu Arg Arg Arg Leu  Asn Glu Glu 
    2120                 2125                 2130             


Tyr Leu  Ile Lys Arg Leu Ser  His Gln Val Gly Glu  Ala Ser Arg 
    2135                 2140                 2145             


Leu Glu  Lys Ile Ala Arg Ile  Arg Ser Trp Tyr Pro  Ala Ser Val 
    2150                 2155                 2160             


Asp His  Glu Asp Asp Arg Gln  Val Ala Thr Trp Ile  Glu Glu Asn 
    2165                 2170                 2175             


Tyr Lys  Thr Leu Asp Asp Lys  Leu Lys Gly Leu Lys  Leu Glu Ser 
    2180                 2185                 2190             


Phe Ala  Gln Asp Leu Ala Lys  Lys Ile Arg Ser Asp  His Asp Asn 
    2195                 2200                 2205             


Ala Ile  Asp Gly Leu Ser Glu  Val Ile Lys Met Leu  Ser Thr Asp 
    2210                 2215                 2220             


Asp Lys  Glu Lys Leu Leu Lys  Thr Leu Lys 
    2225                 2230             


<210>  208
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 3-hydroxy-3-methyl-glutaryl-CoA reductase (Sc_tHMG1)

<400>  208

Met Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe Thr Ala Pro 
1               5                   10                  15      


Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr Val Ile Ser 
            20                  25                  30          


Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser Ser Ser Gly 
        35                  40                  45              


Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile Glu Ser Leu 
    50                  55                  60                  


Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala Leu Val Ile 
                85                  90                  95      


His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu Gly Asp Thr 
            100                 105                 110         


Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile Leu Ala Glu 
        115                 120                 125             


Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn Tyr Asp Tyr 
    130                 135                 140                 


Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr Met Pro 
145                 150                 155                 160 


Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly Thr Ser Tyr 
                165                 170                 175     


His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Ala Met 
            180                 185                 190         


Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr Val Leu 
        195                 200                 205             


Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro Thr Leu 
    210                 215                 220                 


Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu Gly Gln 
225                 230                 235                 240 


Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu 
                245                 250                 255     


Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met Arg Phe 
            260                 265                 270         


Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys Gly 
        275                 280                 285             


Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp Glu Asp 
    290                 295                 300                 


Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro 
305                 310                 315                 320 


Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala Glu 
                325                 330                 335     


Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys Ser Asp Val 
            340                 345                 350         


Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val Gly Ser Ala 
        355                 360                 365             


Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn Leu Val 
    370                 375                 380                 


Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn Val Glu 
385                 390                 395                 400 


Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp Leu Arg 
                405                 410                 415     


Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly Gly 
            420                 425                 430         


Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly Val Arg 
        435                 440                 445             


Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln Leu Ala Arg 
    450                 455                 460                 


Ile Val Ala Cys Ala Val Leu Ala Gly Glu Leu Ser Leu Cys Ala Ala 
465                 470                 475                 480 


Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn Arg Lys 
                485                 490                 495     


Pro Ala Glu Pro Thr Lys Pro Asn Asn Leu Asp Ala Thr Asp Ile Asn 
            500                 505                 510         


Arg Leu Lys Asp Gly Ser Val Thr Cys Ile Lys Ser 
        515                 520                 


<210>  209
<211>  1197
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  209
atgtctcaga acgtttacat tgtatcgact gccagaaccc caattggttc attccagggt       60

tctctatcct ccaagacagc agtggaattg ggtgctgttg ctttaaaagg cgccttggct      120

aaggttccag aattggatgc atccaaggat tttgacgaaa ttatttttgg taacgttctt      180

tctgccaatt tgggccaagc tccggccaga caagttgctt tggctgccgg tttgagtaat      240

catatcgttg caagcacagt taacaaggtc tgtgcatccg ctatgaaggc aatcattttg      300

ggtgctcaat ccatcaaatg tggtaatgct gatgttgtcg tagctggtgg ttgtgaatct      360

atgactaacg caccatacta catgccagca gcccgtgcgg gtgccaaatt tggccaaact      420

gttcttgttg atggtgtcga aagagatggg ttgaacgatg cgtacgatgg tctagccatg      480

ggtgtacacg cagaaaagtg tgcccgtgat tgggatatta ctagagaaca acaagacaat      540

tttgccatcg aatcctacca aaaatctcaa aaatctcaaa aggaaggtaa attcgacaat      600

gaaattgtac ctgttaccat taagggattt agaggtaagc ctgatactca agtcacgaag      660

gacgaggaac ctgctagatt acacgttgaa aaattgagat ctgcaaggac tgttttccaa      720

aaagaaaacg gtactgttac tgccgctaac gcttctccaa tcaacgatgg tgctgcagcc      780

gtcatcttgg tttccgaaaa agttttgaag gaaaagaatt tgaagccttt ggctattatc      840

aaaggttggg gtgaggccgc tcatcaacca gctgatttta catgggctcc atctcttgca      900

gttccaaagg ctttgaaaca tgctggcatc gaagacatca attctgttga ttactttgaa      960

ttcaatgaag ccttttcggt tgtcggtttg gtgaacacta agattttgaa gctagaccca     1020

tctaaggtta atgtatatgg tggtgctgtt gctctaggtc acccattggg ttgttctggt     1080

gctagagtgg ttgttacact gctatccatc ttacagcaag aaggaggtaa gatcggtgtt     1140

gccgccattt gtaatggtgg tggtggtgct tcctctattg tcattgaaaa gatatga        1197


<210>  210
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t112

<400>  210
atgtcttacg ttgtcaaggg tatgatctct attgcttgtg gtttgttcgg tagagaattg       60

tttaacaaca gacacttgtt ctcttggggt ttgatgtgga aagctttctt cgctttggtc      120

ccaattttgt ctttcaattt cttcgccgcc atcatgaacc aaatctacga tgttgatatc      180

gaccgtatca acaagccaga cttaccttta gtttccggtg aaatgtccat tgaaactgct      240

tggatcttgt ctatcattgt tgccttgact ggtttaattg ttactattaa gttgaagtcc      300

gctccattgt ttgtcttcat ctacatcttc ggtatcttcg ctggtttcgc ttactccgtc      360

ccacctatta gatggaaaca atatcctttt accaatttct tgatcactat ttcctctcat      420

gttggtttgg ctttcacttc ttactctgcc accacttctg ctttaggttt gcctttcgtt      480

tggcgtcctg ccttctcttt cattattgct ttcatgactg tcatgggtat gactattgcc      540

tttgctaaag acatttctga tatcgaaggt gatgctaagt acggtgtctc taccgttgct      600

accaagttag gtgctagaaa tatgactttt gttgtttctg gtgtcttatt gttgaactac      660

ttggtttcta tctctattgg tatcatttgg ccacaagttt tcaagtctaa cattatgatc      720

ttgtctcatg ctattttggc tttctgtttg atctttcaaa ctcgtgaatt agccttagcc      780

aattatgcct ctgccccatc ccgtcaattt ttcgaattca tctggttgtt atactatgcc      840

gaatacttcg tttacgtctt catttaa                                          867


<210>  211
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t112

<400>  211

Met Ser Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
1               5                   10                  15      


Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met 
            20                  25                  30          


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
        35                  40                  45              


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
    50                  55                  60                  


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
65                  70                  75                  80  


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
                85                  90                  95      


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
            100                 105                 110         


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr 
        115                 120                 125             


Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
    130                 135                 140                 


Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val 
145                 150                 155                 160 


Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly 
                165                 170                 175     


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
            180                 185                 190         


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
        195                 200                 205             


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile 
    210                 215                 220                 


Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile 
225                 230                 235                 240 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
                245                 250                 255     


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
            260                 265                 270         


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        275                 280                 285             


<210>  212
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t131 nucleotide sequence

<400>  212
atgtctaaca acagacactt gttctcttgg ggtttgatgt ggaaagcttt cttcgctttg       60

gtcccaattt tgtctttcaa tttcttcgcc gccatcatga accaaatcta cgatgttgat      120

atcgaccgta tcaacaagcc agacttacct ttagtttccg gtgaaatgtc cattgaaact      180

gcttggatct tgtctatcat tgttgccttg actggtttaa ttgttactat taagttgaag      240

tccgctccat tgtttgtctt catctacatc ttcggtatct tcgctggttt cgcttactcc      300

gtcccaccta ttagatggaa acaatatcct tttaccaatt tcttgatcac tatttcctct      360

catgttggtt tggctttcac ttcttactct gccaccactt ctgctttagg tttgcctttc      420

gtttggcgtc ctgccttctc tttcattatt gctttcatga ctgtcatggg tatgactatt      480

gcctttgcta aagacatttc tgatatcgaa ggtgatgcta agtacggtgt ctctaccgtt      540

gctaccaagt taggtgctag aaatatgact tttgttgttt ctggtgtctt attgttgaac      600

tacttggttt ctatctctat tggtatcatt tggccacaag ttttcaagtc taacattatg      660

atcttgtctc atgctatttt ggctttctgt ttgatctttc aaactcgtga attagcctta      720

gccaattatg cctctgcccc atcccgtcaa tttttcgaat tcatctggtt gttatactat      780

gccgaatact tcgtttacgt cttcatttaa                                       810


<210>  213
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t131

<400>  213

Met Ser Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys Ala 
1               5                   10                  15      


Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile 
            20                  25                  30          


Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro Asp 
        35                  40                  45              


Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile Leu 
    50                  55                  60                  


Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu Lys 
65                  70                  75                  80  


Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly 
                85                  90                  95      


Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr 
            100                 105                 110         


Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr Ser 
        115                 120                 125             


Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg Pro 
    130                 135                 140                 


Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr Ile 
145                 150                 155                 160 


Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly 
                165                 170                 175     


Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe Val 
            180                 185                 190         


Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly 
        195                 200                 205             


Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser His 
    210                 215                 220                 


Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu 
225                 230                 235                 240 


Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp 
                245                 250                 255     


Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            260                 265                 


<210>  214
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t142 nucleotide sequence

<400>  214
atgtcttgga aagctttctt cgctttggtc ccaattttgt ctttcaattt cttcgccgcc       60

atcatgaacc aaatctacga tgttgatatc gaccgtatca acaagccaga cttaccttta      120

gtttccggtg aaatgtccat tgaaactgct tggatcttgt ctatcattgt tgccttgact      180

ggtttaattg ttactattaa gttgaagtcc gctccattgt ttgtcttcat ctacatcttc      240

ggtatcttcg ctggtttcgc ttactccgtc ccacctatta gatggaaaca atatcctttt      300

accaatttct tgatcactat ttcctctcat gttggtttgg ctttcacttc ttactctgcc      360

accacttctg ctttaggttt gcctttcgtt tggcgtcctg ccttctcttt cattattgct      420

ttcatgactg tcatgggtat gactattgcc tttgctaaag acatttctga tatcgaaggt      480

gatgctaagt acggtgtctc taccgttgct accaagttag gtgctagaaa tatgactttt      540

gttgtttctg gtgtcttatt gttgaactac ttggtttcta tctctattgg tatcatttgg      600

ccacaagttt tcaagtctaa cattatgatc ttgtctcatg ctattttggc tttctgtttg      660

atctttcaaa ctcgtgaatt agccttagcc aattatgcct ctgccccatc ccgtcaattt      720

ttcgaattca tctggttgtt atactatgcc gaatacttcg tttacgtctt catttaa         777


<210>  215
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t142

<400>  215

Met Ser Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn 
1               5                   10                  15      


Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg 
            20                  25                  30          


Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu 
        35                  40                  45              


Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val 
    50                  55                  60                  


Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe 
65                  70                  75                  80  


Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys 
                85                  90                  95      


Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly 
            100                 105                 110         


Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro 
        115                 120                 125             


Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val 
    130                 135                 140                 


Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly 
145                 150                 155                 160 


Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg 
                165                 170                 175     


Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val 
            180                 185                 190         


Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile 
        195                 200                 205             


Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr 
    210                 215                 220                 


Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe 
225                 230                 235                 240 


Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val 
                245                 250                 255     


Phe Ile 
        


<210>  216
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t166 nucleotide sequence

<400>  216
atgtctgatg ttgatatcga ccgtatcaac aagccagact tacctttagt ttccggtgaa       60

atgtccattg aaactgcttg gatcttgtct atcattgttg ccttgactgg tttaattgtt      120

actattaagt tgaagtccgc tccattgttt gtcttcatct acatcttcgg tatcttcgct      180

ggtttcgctt actccgtccc acctattaga tggaaacaat atccttttac caatttcttg      240

atcactattt cctctcatgt tggtttggct ttcacttctt actctgccac cacttctgct      300

ttaggtttgc ctttcgtttg gcgtcctgcc ttctctttca ttattgcttt catgactgtc      360

atgggtatga ctattgcctt tgctaaagac atttctgata tcgaaggtga tgctaagtac      420

ggtgtctcta ccgttgctac caagttaggt gctagaaata tgacttttgt tgtttctggt      480

gtcttattgt tgaactactt ggtttctatc tctattggta tcatttggcc acaagttttc      540

aagtctaaca ttatgatctt gtctcatgct attttggctt tctgtttgat ctttcaaact      600

cgtgaattag ccttagccaa ttatgcctct gccccatccc gtcaattttt cgaattcatc      660

tggttgttat actatgccga atacttcgtt tacgtcttca tttaa                      705


<210>  217
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t166

<400>  217

Met Ser Asp Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu 
1               5                   10                  15      


Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile 
            20                  25                  30          


Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro 
        35                  40                  45              


Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr 
    50                  55                  60                  


Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu 
65                  70                  75                  80  


Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala 
                85                  90                  95      


Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg Pro Ala Phe Ser 
            100                 105                 110         


Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr Ile Ala Phe Ala 
        115                 120                 125             


Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr 
    130                 135                 140                 


Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly 
145                 150                 155                 160 


Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile Trp 
                165                 170                 175     


Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser His Ala Ile Leu 
            180                 185                 190         


Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr 
        195                 200                 205             


Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr 
    210                 215                 220                 


Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
225                 230                 


<210>  218
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t186 nucleotide sequence

<400>  218
atgtctattg aaactgcttg gatcttgtct atcattgttg ccttgactgg tttaattgtt       60

actattaagt tgaagtccgc tccattgttt gtcttcatct acatcttcgg tatcttcgct      120

ggtttcgctt actccgtccc acctattaga tggaaacaat atccttttac caatttcttg      180

atcactattt cctctcatgt tggtttggct ttcacttctt actctgccac cacttctgct      240

ttaggtttgc ctttcgtttg gcgtcctgcc ttctctttca ttattgcttt catgactgtc      300

atgggtatga ctattgcctt tgctaaagac atttctgata tcgaaggtga tgctaagtac      360

ggtgtctcta ccgttgctac caagttaggt gctagaaata tgacttttgt tgtttctggt      420

gtcttattgt tgaactactt ggtttctatc tctattggta tcatttggcc acaagttttc      480

aagtctaaca ttatgatctt gtctcatgct attttggctt tctgtttgat ctttcaaact      540

cgtgaattag ccttagccaa ttatgcctct gccccatccc gtcaattttt cgaattcatc      600

tggttgttat actatgccga atacttcgtt tacgtcttca tttaa                      645


<210>  219
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t186

<400>  219

Met Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr 
1               5                   10                  15      


Gly Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe 
            20                  25                  30          


Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro 
        35                  40                  45              


Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser 
    50                  55                  60                  


Ser His Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala 
65                  70                  75                  80  


Leu Gly Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala 
                85                  90                  95      


Phe Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser 
            100                 105                 110         


Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys 
        115                 120                 125             


Leu Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu 
    130                 135                 140                 


Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe 
145                 150                 155                 160 


Lys Ser Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu 
                165                 170                 175     


Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro 
            180                 185                 190         


Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr 
        195                 200                 205             


Phe Val Tyr Val Phe Ile 
    210                 


<210>  220
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsGOT (CsPT1) nucleotide sequence

<400>  220
atgggtttat cttccgtttg tactttttct ttccaaacta actaccacac tttgttaaat       60

ccacacaaca acaaccctaa aacctccttg ttatgttaca gacacccaaa gacccctatt      120

aaatactcct acaacaactt cccatccaaa cactgctcca ctaagtcctt tcacttgcaa      180

aacaagtgtt ctgaatcctt gtccattgcc aagaactcta ttcgtgccgc tactactaac      240

caaactgagc cacctgaatc cgataaccac tccgtcgcca ccaagatctt gaattttggt      300

aaagcttgct ggaaattgca aagaccatac actattattg ctttcacttc ctgtgcttgt      360

ggtttattcg gtaaggaatt attgcataac accaacttga tttcttggtc cttaatgttc      420

aaagccttct tctttttagt tgccatttta tgtattgctt ctttcactac tactattaat      480

caaatttacg atttgcacat tgacagaatc aataagcctg acttgccatt agcttccggt      540

gaaatttctg ttaacactgc ttggatcatg tccatcattg tcgctttgtt cggtttaatt      600

atcaccatca aaatgaaggg tggtcctttg tacatcttcg gttattgctt cggtattttc      660

ggtggtattg tctactctgt cccaccattc agatggaagc aaaacccatc cactgccttt      720

ttgttgaatt tcttggctca catcattacc aattttactt tctactatgc ctcccgtgct      780

gctttaggtt tgccttttga gttacgtcca tccttcactt ttttattggc ttttatgaag      840

tccatgggtt ctgctttagc cttaattaag gacgcctctg acgttgaagg tgatactaag      900

ttcggtatct ctactttagc ctctaagtac ggttctcgta acttgacctt gttctgttct      960

ggtattgtct tgttgtctta cgtcgccgct attttggccg gtatcatctg gccacaagct     1020

ttcaactcta acgttatgtt gttgtctcat gctatcttag ctttctggtt gatcttacaa     1080

accagagact tcgctttgac taactacgac ccagaagccg gtcgtagatt ctacgaattc     1140

atgtggaaat tgtactacgc cgagtacttg gtctacgttt tcatttag                  1188


<210>  221
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4t nucleotide sequence

<400>  221
atgtctgctg gctctgacca aattgaaggt tccccgcatc acgaatcaga taatagtatt       60

gccacaaaga tcttaaactt tgggcataca tgttggaaat tacaaaggcc ctacgtcgtc      120

aaaggaatga taagcatcgc ttgcggtctg ttcggaaggg aattatttaa caataggcat      180

ctattcagct gggggttaat gtggaaagct ttcttcgcgt tagtgccaat cctaagcttt      240

aactttttcg ccgccatcat gaaccagatt tatgatgttg atatcgacag gataaataag      300

ccagatcttc cattggtatc cggtgaaatg tcaatagaaa ctgcatggat attatctatt      360

atcgttgcgc tgaccggact gatagtaaca atcaaattga aatctgcacc cctgtttgtt      420

tttatatata tatttggtat tttcgctgga ttcgcttact cagtgccacc tatcaggtgg      480

aagcagtacc cattcacgaa ttttctgatc acgatctcta gccacgtcgg gttagcgttc      540

acatcttact ctgcaaccac gagtgccttg gggcttcctt tcgtctggcg tccagctttt      600

agttttatca ttgcctttat gaccgtaatg ggaatgacga tcgcattcgc aaaggacatt      660

tctgacatag agggggatgc aaaatacggt gtctccactg tggcgacaaa attaggagct      720

aggaatatga ctttcgtggt gtccggtgta ttattactaa attatctggt atctataagt      780

atcggcatca tatggccgca agtgtttaaa tccaacatta tgatactgag tcatgctatt      840

ttggcttttt gtctgatttt tcagacgcgt gagttggcgc ttgcaaacta tgcctctgcg      900

cccagcaggc agttttttga attcatatgg ttattgtact atgccgagta tttcgtctac      960

gtatttattt aa                                                          972


<210>  222
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsGOT_t75 (CsPT1_t75) nucleotide sequence

<400>  222
atgtctgccg ctactactaa ccaaactgag ccacctgaat ccgataacca ctccgtcgcc       60

accaagatct tgaattttgg taaagcttgc tggaaattgc aaagaccata cactattatt      120

gctttcactt cctgtgcttg tggtttattc ggtaaggaat tattgcataa caccaacttg      180

atttcttggt ccttaatgtt caaagccttc ttctttttag ttgccatttt atgtattgct      240

tctttcacta ctactattaa tcaaatttac gatttgcaca ttgacagaat caataagcct      300

gacttgccat tagcttccgg tgaaatttct gttaacactg cttggatcat gtccatcatt      360

gtcgctttgt tcggtttaat tatcaccatc aaaatgaagg gtggtccttt gtacatcttc      420

ggttattgct tcggtatttt cggtggtatt gtctactctg tcccaccatt cagatggaag      480

caaaacccat ccactgcctt tttgttgaat ttcttggctc acatcattac caattttact      540

ttctactatg cctcccgtgc tgctttaggt ttgccttttg agttacgtcc atccttcact      600

tttttattgg cttttatgaa gtccatgggt tctgctttag ccttaattaa ggacgcctct      660

gacgttgaag gtgatactaa gttcggtatc tctactttag cctctaagta cggttctcgt      720

aacttgacct tgttctgttc tggtattgtc ttgttgtctt acgtcgccgc tattttggcc      780

ggtatcatct ggccacaagc tttcaactct aacgttatgt tgttgtctca tgctatctta      840

gctttctggt tgatcttaca aaccagagac ttcgctttga ctaactacga cccagaagcc      900

ggtcgtagat tctacgaatt catgtggaaa ttgtactacg ccgagtactt ggtctacgtt      960

ttcatttag                                                              969


<210>  223
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsGOT_t75 (CsPT1_t75)

<400>  223

Met Ser Ala Ala Thr Thr Asn Gln Thr Glu Pro Pro Glu Ser Asp Asn 
1               5                   10                  15      


His Ser Val Ala Thr Lys Ile Leu Asn Phe Gly Lys Ala Cys Trp Lys 
            20                  25                  30          


Leu Gln Arg Pro Tyr Thr Ile Ile Ala Phe Thr Ser Cys Ala Cys Gly 
        35                  40                  45              


Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Ser 
    50                  55                  60                  


Leu Met Phe Lys Ala Phe Phe Phe Leu Val Ala Ile Leu Cys Ile Ala 
65                  70                  75                  80  


Ser Phe Thr Thr Thr Ile Asn Gln Ile Tyr Asp Leu His Ile Asp Arg 
                85                  90                  95      


Ile Asn Lys Pro Asp Leu Pro Leu Ala Ser Gly Glu Ile Ser Val Asn 
            100                 105                 110         


Thr Ala Trp Ile Met Ser Ile Ile Val Ala Leu Phe Gly Leu Ile Ile 
        115                 120                 125             


Thr Ile Lys Met Lys Gly Gly Pro Leu Tyr Ile Phe Gly Tyr Cys Phe 
    130                 135                 140                 


Gly Ile Phe Gly Gly Ile Val Tyr Ser Val Pro Pro Phe Arg Trp Lys 
145                 150                 155                 160 


Gln Asn Pro Ser Thr Ala Phe Leu Leu Asn Phe Leu Ala His Ile Ile 
                165                 170                 175     


Thr Asn Phe Thr Phe Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro 
            180                 185                 190         


Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Lys Ser 
        195                 200                 205             


Met Gly Ser Ala Leu Ala Leu Ile Lys Asp Ala Ser Asp Val Glu Gly 
    210                 215                 220                 


Asp Thr Lys Phe Gly Ile Ser Thr Leu Ala Ser Lys Tyr Gly Ser Arg 
225                 230                 235                 240 


Asn Leu Thr Leu Phe Cys Ser Gly Ile Val Leu Leu Ser Tyr Val Ala 
                245                 250                 255     


Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val 
            260                 265                 270         


Met Leu Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile Leu Gln Thr 
        275                 280                 285             


Arg Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly Arg Arg Phe 
    290                 295                 300                 


Tyr Glu Phe Met Trp Lys Leu Tyr Tyr Ala Glu Tyr Leu Val Tyr Val 
305                 310                 315                 320 


Phe Ile 
        


<210>  224
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial truncated geranyl pyrophosphate olivetolic acid 
       geranyltransferase CsPT4_t76 (CsPT4t) nucleotide sequence

<400>  224
atgtccgccg gttctgatca aatcgaaggt tcccctcatc atgagtccga taactccatt       60

gctactaaaa ttttaaattt cggtcatact tgttggaagt tgcaacgtcc ttacgttgtc      120

aagggtatga tctctattgc ttgtggtttg ttcggtagag aattgtttaa caacagacac      180

ttgttctctt ggggtttgat gtggaaagct ttcttcgctt tggtcccaat tttgtctttc      240

aatttcttcg ccgccatcat gaaccaaatc tacgatgttg atatcgaccg tatcaacaag      300

ccagacttac ctttagtttc cggtgaaatg tccattgaaa ctgcttggat cttgtctatc      360

attgttgcct tgactggttt aattgttact attaagttga agtccgctcc attgtttgtc      420

ttcatctaca tcttcggtat cttcgctggt ttcgcttact ccgtcccacc tattagatgg      480

aaacaatatc cttttaccaa tttcttgatc actatttcct ctcatgttgg tttggctttc      540

acttcttact ctgccaccac ttctgcttta ggtttgcctt tcgtttggcg tcctgccttc      600

tctttcatta ttgctttcat gactgtcatg ggtatgacta ttgcctttgc taaagacatt      660

tctgatatcg aaggtgatgc taagtacggt gtctctaccg ttgctaccaa gttaggtgct      720

agaaatatga cttttgttgt ttctggtgtc ttattgttga actacttggt ttctatctct      780

attggtatca tttggccaca agttttcaag tctaacatta tgatcttgtc tcatgctatt      840

ttggctttct gtttgatctt tcaaactcgt gaattagcct tagccaatta tgcctctgcc      900

ccatcccgtc aatttttcga attcatctgg ttgttatact atgccgaata cttcgtttac      960

gtcttcattt aa                                                          972


<210>  225
<211>  1197
<212>  DNA
<213>  Cannabis sativa

<400>  225
atgggactct cattagtttg taccttttca tttcaaacta attatcatac tttattaaac       60

cctcataata agaatcccaa aaactcatta ttatcttatc aacaccccaa aacaccaata      120

attaaatcct cttatgataa ttttccctct aaatattgct taaccaagaa ctttcattta      180

cttggactca attcacacaa cagaataagc tcacaatcaa ggtccattag ggcaggtagc      240

gatcaaattg aaggttctcc tcatcatgaa tctgataatt caatagcaac taaaatttta      300

aattttggac atacttgttg gaaacttcaa agaccatatg tagtaaaagg gatgatttca      360

atcgcttgtg gtttgtttgg gagagagttg ttcaataaca gacatttatt cagttggggt      420

ttgatgtgga aggcattctt tgctttggtg cctatattgt ccttcaattt ctttgcagca      480

atcatgaatc aaatttacga tgtggacatc gacaggataa acaagcctga tctaccacta      540

gtttcagggg aaatgtcaat tgaaacagct tggattttga gcataattgt ggcactaact      600

gggttgatag taactataaa attgaaatct gcaccacttt ttgttttcat ttacattttt      660

ggtatatttg ctgggtttgc ctattctgtt ccaccaatta gatggaagca atatcctttt      720

accaattttc taattaccat atcgagtcat gtgggcttag ctttcacatc atattctgca      780

accacatcag ctcttggttt accatttgtg tggaggcctg cttttagttt catcatagca      840

ttcatgacag ttatgggtat gactattgct tttgccaaag atatttcaga tattgaaggc      900

gacgccaaat atggggtatc aactgttgca accaaattag gtgctaggaa catgacattt      960

gttgtttctg gagttcttct tctaaactac ttggtttcta tatctattgg gataatttgg     1020

cctcaggttt tcaagagtaa cataatgata ctttctcatg caatcttagc attttgctta     1080

atcttccaga ctcgtgagct tgctctagca aattacgcct cggcgccaag cagacaattc     1140

ttcgagttta tctggttgct atattatgct gaatactttg tatatgtatt tatataa        1197


