                               SEQUENCE LISTING

<110> 10X GENOMICS, INC.
 
<120> MMLV REVERSE TRANSCRIPTASE VARIANTS

<130> 43487-763.601

<140> PCT/US2018/029641
<141> 2018-04-26

<150> 62/490,492
<151> 2017-04-26

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 2043
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atgggtagct cacatcacca tcatcatcat tcttctggtc tggtcccacg cggcagcact       60

tggctgtctg atttccctca ggcgtgggcc gaaacgggtg gcatgggtct ggcagtgcgt      120

caggcaccgc tgattattcc gctgaaagcg acgtcgaccc cggtgagcat caagcaatat      180

ccgatgtccc aagaggcgcg cttaggtatt aagccgcaca ttcagcgtct gctggatcaa      240

ggtattctgg ttccgtgtca gagcccgtgg aataccccgc ttctcccggt gaagaaaccg      300

ggcacgaacg attaccgtcc agtccaagac ttgcgcgaag ttaacaagcg cgttgaagat      360

attcacccga ccgtcccgaa cccgtacaat ctgctgagcg gtctgccgcc aagccaccaa      420

tggtacaccg tgctggatct gaaagatgct ttcttctgtc tgcgtctgca cccaaccagc      480

cagcctctgt ttgcatttga gtggcgtgac cctgagatgg gtattagcgg ccagctgacg      540

tggacccgcc tgccgcaagg ttttaagaat tcccctacgc tgtttgacga agcgctgcac      600

cgtgacctgg cggatttccg tatccagcac ccggacctga tcttgctgca gtacgttgat      660

gacctgttgc tggcggcgac gagcgagctg gattgccaac agggcacccg tgcgctgttg      720

cagaccttgg gtaacctggg ttatcgcgct agcgcgaaga aagcgcagat ttgccaaaaa      780

caagttaagt atctgggcta cctgttaaag gaaggccaac gttggctgac cgaagcccgc      840

aaagaaactg tcatgggtca gccgaccccg aaaacgccac gccaactgcg tgagttcttg      900

ggcaccgcgg gtttctgccg cctgtggatc ccgggctttg ccgaaatggc agccccgctg      960

tatccgttga ccaagaccgg caccctgttc aactggggtc cggaccagca gaaagcgtac     1020

caagaaatta aacaagcact gctgacggca ccggcgctgg gtctgccgga cctgaccaag     1080

ccgtttgagc tgttcgtgga tgagaagcaa ggttacgcga agggcgtgtt gacccagaaa     1140

ttgggtccgt ggcgtcgtcc ggttgcatac ctgtccaaga aactggaccc ggttgctgct     1200

ggttggccgc cttgcctgcg catggttgcc gctatcgcgg tgctgactaa agacgcgggt     1260

aagctgacga tgggtcaacc gctggtgatc aaggcaccgc atgcagtcga ggcccttgtt     1320

aagcaaccgc cagatagatg gctgagcaac gcgcgtatga cgcattacca ggcactgctg     1380

ttggacaccg atcgtgtgca gtttggcccg gtcgttgcgc tcaacccggc gaccctgctg     1440

ccgctcccgg aagaaggctt gcagcacaac tgtttggaca tcctggcaga ggcgcacggc     1500

actcgcccgg atctgacgga ccagccgctg ccggacgccg atcatacctg gtatacgaat     1560

ggtagcagcc tgttgcaaga gggtcagcgt aaggccggtg ccgcggtcac caccgagact     1620

gaagtgattt gggctaaagc attgcctgcg ggtaccagcg cgcagcgtgc cgagctgatc     1680

gcactgaccc aagcgctgaa aatggctgag ggtaagaaac tgaatgtgta cacggatagc     1740

cgttatgcct ttgcgaccgc ccacattcac ggcgagatct atcgccgtcg cggcctgctg     1800

acgtccgaag gcaaagagat caagaataaa gacgaaattc tggcgctgct gaaagcgctg     1860

ttcctgccga aacgtctgtc gatcatccat tgcccgggtc accagaaagg ccacagcgca     1920

gaggcgcgtg gtaatcgcat ggctgaccag gctgcgcgta aagccgcaat taccgaaacc     1980

ccggacacca gcacgctgct gatcgagaat agcagcccga acagccgtct gatcaattga     2040

taa                                                                   2043


<210> 2
<211> 679
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr 
            20                  25                  30          


Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu 
        35                  40                  45              


Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln 
    50                  55                  60                  


Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln 
65                  70                  75                  80  


Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro 
                85                  90                  95      


Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg 
            100                 105                 110         


Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro 
        115                 120                 125             


Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val 
    130                 135                 140                 


Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser 
145                 150                 155                 160 


Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser 
                165                 170                 175     


Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro 
            180                 185                 190         


Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile 
        195                 200                 205             


Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu 
    210                 215                 220                 


Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu 
225                 230                 235                 240 


Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln 
                245                 250                 255     


Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly 
            260                 265                 270         


Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro 
        275                 280                 285             


Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly 
    290                 295                 300                 


Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu 
305                 310                 315                 320 


Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln 
                325                 330                 335     


Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala 
            340                 345                 350         


Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu 
        355                 360                 365             


Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp 
    370                 375                 380                 


Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala 
385                 390                 395                 400 


Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr 
                405                 410                 415     


Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Lys Ala 
            420                 425                 430         


Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu 
        435                 440                 445             


Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp 
    450                 455                 460                 


Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu 
465                 470                 475                 480 


Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala 
                485                 490                 495     


Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp 
            500                 505                 510         


Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly 
        515                 520                 525             


Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp 
    530                 535                 540                 


Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile 
545                 550                 555                 560 


Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val 
                565                 570                 575     


Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu 
            580                 585                 590         


Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys Glu Ile Lys 
        595                 600                 605             


Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys 
    610                 615                 620                 


Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala 
625                 630                 635                 640 


Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala 
                645                 650                 655     


Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile Glu Asn Ser Ser 
            660                 665                 670         


Pro Asn Ser Arg Leu Ile Asn 
        675                 


<210> 3
<211> 671
<212> PRT
<213> Moloney murine leukemia virus

<400> 3
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 4
<211> 2043
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgggtagct cacatcacca tcatcatcat tcttctggtc tggtcccacg cggcagcact       60

tggctgtctg atttccctca ggcgtgggcc gaaacgggtg gcatgggtct ggcagtgcgt      120

caggcaccgc tgattattcc gctgaaagcg acgtcgaccc cggtgagcat caagcaatat      180

ccgatgtccc aaaaggcgcg cttaggtatt aagccgcaca ttcagcgtct gctggatcaa      240

ggtattctgg ttccgtgtca gagcccgtgg aataccccgc ttctcccggt gaagaaaccg      300

ggcacgaacg attaccgtcc agtccaagac ttgcgcgaag ttaacaagcg cgttgaagat      360

attcacccga ccgtcccgaa cccgtacaat ctgctgagcg gtccgccgcc aagccaccaa      420

tggtacaccg tgctggatct gaaagatgct ttcttctgtc tgcgtctgca cccaaccagc      480

cagcctctgt ttgcatttga gtggcgtgac cctgagatgg gtattagcgg ccagctgacg      540

tggacccgcc tgccgcaagg ttttaagaat tcccctacgc tgtttaacga agcgctgcac      600

cgtgacctgg cggatttccg tatccagcac ccggacctga tcttgctgca gtacgttgat      660

gacctgttgc tggcggcgac gagcgagctg gattgccaac agggcacccg tgcgctgttg      720

cagaccttgg gtaacctggg ttatcgcgct agcgcgaaga aagcgcagat ttgccaaaaa      780

caagttaagt atctgggcta cctgttaaag gaaggccaac gttggctgac cgaagcccgc      840

aaagaaactg tcatgggtca gccgaccccg aaaacgccac gccaactgcg taggttcttg      900

ggcaaagcgg gtttctgccg cctgttcatc ccgggctttg ccgaaatggc agccccgctg      960

tatccgttga ccaagccggg caccctgttc aactggggtc cggaccagca gaaagcgtac     1020

caagaaatta aacaagcact gctgacggca ccggcgctgg gtctgccgga cctgaccaag     1080

ccgtttgagc tgttcgtgga tgagaagcaa ggttacgcga agggcgtgtt gacccagaaa     1140

ttgggtccgt ggcgtcgtcc ggttgcatac ctgtccaaga aactggaccc ggttgctgct     1200

ggttggccgc cttgcctgcg catggttgcc gctatcgcgg tgctgactaa agacgcgggt     1260

aagctgacga tgggtcaacc gctggtgatc aaggcaccgc atgcagtcga ggcccttgtt     1320

aagcaaccgg caggcagatg gctgagcaag gcgcgtatga cgcattacca ggcactgctg     1380

ttggacaccg atcgtgtgca gtttggcccg gtcgttgcgc tcaacccggc gaccctgctg     1440

ccgctcccgg aagaaggctt gcagcacaac tgtttggaca tcctggcaga ggcgcacggc     1500

actcgcccgg atctgacgga ccagccgctg ccggacgccg atcatacctg gtatacgaat     1560

ggtagcagcc tgttgcaaga gggtcagcgt aaggccggtg ccgcggtcac caccgagact     1620

gaagtgattt gggctaaagc attgcctgcg ggtaccagcg cgcagcgtgc cgagctgatc     1680

gcactgaccc aagcgctgaa aatggctgag ggtaagaaac tgaatgtgta cacggatagc     1740

cgttatgcct ttgcgaccgc ccacattcac ggcgagatct atcgccgtcg cggctggctg     1800

acgtccaaag gcaaagagat caagaataaa gacgaaattc tggcgctgct gaaagcgctg     1860

ttcctgccga aacgtctgtc gatcatccat tgcccgggtc accagaaagg ccacagcgca     1920

gaggcgcgtg gtaatcgcat ggctgaccag gctgcgcgta aagccgcaat taccgaaacc     1980

ccggacacca gcacgctgct gatcgagaat agcagcccga acagccgtct gatcaattga     2040

taa                                                                   2043


<210> 5
<211> 679
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr 
            20                  25                  30          


Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu 
        35                  40                  45              


Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln 
    50                  55                  60                  


Lys Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln 
65                  70                  75                  80  


Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro 
                85                  90                  95      


Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg 
            100                 105                 110         


Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro 
        115                 120                 125             


Tyr Asn Leu Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val 
    130                 135                 140                 


Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser 
145                 150                 155                 160 


Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser 
                165                 170                 175     


Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro 
            180                 185                 190         


Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile 
        195                 200                 205             


Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu 
    210                 215                 220                 


Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu 
225                 230                 235                 240 


Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln 
                245                 250                 255     


Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly 
            260                 265                 270         


Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro 
        275                 280                 285             


Thr Pro Lys Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly 
    290                 295                 300                 


Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu 
305                 310                 315                 320 


Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln 
                325                 330                 335     


Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala 
            340                 345                 350         


Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu 
        355                 360                 365             


Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp 
    370                 375                 380                 


Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala 
385                 390                 395                 400 


Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr 
                405                 410                 415     


Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Lys Ala 
            420                 425                 430         


Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu 
        435                 440                 445             


Ser Lys Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp 
    450                 455                 460                 


Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu 
465                 470                 475                 480 


Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala 
                485                 490                 495     


Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp 
            500                 505                 510         


Ala Asp His Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly 
        515                 520                 525             


Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp 
    530                 535                 540                 


Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile 
545                 550                 555                 560 


Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val 
                565                 570                 575     


Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu 
            580                 585                 590         


Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys 
        595                 600                 605             


Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys 
    610                 615                 620                 


Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala 
625                 630                 635                 640 


Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala 
                645                 650                 655     


Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile Glu Asn Ser Ser 
            660                 665                 670         


Pro Asn Ser Arg Leu Ile Asn 
        675                 


<210> 6
<211> 648
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met 
1               5                   10                  15      


Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr 
            20                  25                  30          


Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Lys Ala Arg 
        35                  40                  45              


Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu 
    50                  55                  60                  


Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys 
65                  70                  75                  80  


Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn 
                85                  90                  95      


Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu 
            100                 105                 110         


Leu Ser Gly Pro Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu 
        115                 120                 125             


Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu 
    130                 135                 140                 


Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu 
145                 150                 155                 160 


Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe 
                165                 170                 175     


Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro 
            180                 185                 190         


Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr 
        195                 200                 205             


Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu 
    210                 215                 220                 


Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln 
225                 230                 235                 240 


Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp 
                245                 250                 255     


Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys 
            260                 265                 270         


Thr Pro Arg Gln Leu Arg Arg Phe Leu Gly Lys Ala Gly Phe Cys Arg 
        275                 280                 285             


Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu 
    290                 295                 300                 


Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala 
305                 310                 315                 320 


Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu 
                325                 330                 335     


Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln Gly 
            340                 345                 350         


Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro 
        355                 360                 365             


Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp Pro 
    370                 375                 380                 


Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp Ala 
385                 390                 395                 400 


Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Lys Ala Pro His Ala 
                405                 410                 415     


Val Glu Ala Leu Val Lys Gln Pro Ala Gly Arg Trp Leu Ser Lys Ala 
            420                 425                 430         


Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val Gln 
        435                 440                 445             


Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro 
    450                 455                 460                 


Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala His 
465                 470                 475                 480 


Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp His 
                485                 490                 495     


Thr Trp Tyr Thr Asn Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys 
            500                 505                 510         


Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys Ala 
        515                 520                 525             


Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr 
    530                 535                 540                 


Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp 
545                 550                 555                 560 


Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr Arg 
                565                 570                 575     


Arg Arg Gly Trp Leu Thr Ser Lys Gly Lys Glu Ile Lys Asn Lys Asp 
            580                 585                 590         


Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser 
        595                 600                 605             


Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser Ala Glu Ala Arg 
    610                 615                 620                 


Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu 
625                 630                 635                 640 


Thr Pro Asp Thr Ser Thr Leu Leu 
                645             


<210> 7
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Met Arg Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser 
            


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Met Arg Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg 
    


<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 9
His His His His His His 
1               5       


<210> 10
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
aaaaaaaaaa aaaaaa                                                       16


<210> 11
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
aaaaaaaaaa a                                                            11


