                         SEQUENCE LISTING

<110>  Children's Medical Center Corporation
 
<120>  INDUCED MICROGLIA FROM HEMATOPOIETIC AND PLURIPOTENT STEM CELLS

<130>  C1233.70121WO00

<140>  PCT/US2018/029354
<141>  2018-04-25

<150>  US 62/489,985
<151>  2017-04-25

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His 
1               5                   10                  15      


Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys 
            20                  25                  30          


Gln Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
        35                  40                  45              


Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
    50                  55                  60                  


Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
65                  70                  75                  80  


Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                  90                  95      


Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                 105                 110         


Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                 120                 125             


Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                 135                 140                 


Ala Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser 
145                 150                 155                 


<210>  2
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gly Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val 
1               5                   10                  15      


Thr Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys 
            20                  25                  30          


Tyr Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu 
        35                  40                  45              


Met Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe 
    50                  55                  60                  


Ser Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp Lys Leu 
65                  70                  75                  80  


Val Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser 
                85                  90                  95      


Lys Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr 
            100                 105                 110         


Pro Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys 
        115                 120                 125             


Asp Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr 
    130                 135                 140                 


Leu Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met 
145                 150                 155                 160 


Leu Pro Pro Val Ala 
                165 


<210>  3
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala 
145                 150                 155 


<210>  4
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe 
    130             


<210>  5
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
1               5                   10                  15      


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
            20                  25                  30          


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
        35                  40                  45              


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
    50                  55                  60                  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
65                  70                  75                  80  


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
                85                  90                  95      


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
            100                 105                 110         


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125             


<210>  6
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn Glu Glu Cys Thr 
1               5                   10                  15      


Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Ser Arg Leu Gln 
            20                  25                  30          


Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile Ser Val Pro Tyr 
        35                  40                  45              


Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu Gln Arg Ala Gln 
    50                  55                  60                  


Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser 
65                  70                  75                  80  


Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly His Pro Ser Trp 
                85                  90                  95      


Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn Val Gln Gln Gly 
            100                 105                 110         


Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser Val Leu Ser Leu 
        115                 120                 125             


Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg Pro Lys Ala Leu 
    130                 135                 140                 


Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys 
145                 150                 155                 160 


Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val Pro Ser Pro 
                165                 170                 175     


Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala Ala Thr Gln Leu 
            180                 185                 190         


Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro His Ser Thr Gly 
        195                 200                 205             


Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu Leu Pro His His 
    210                 215                 220                 


His His His His His His 
225                 230 


<210>  7
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 
1               5                   10                  15      


Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 
            20                  25                  30          


His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 
        35                  40                  45              


Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 
    50                  55                  60                  


Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 
65                  70                  75                  80  


Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 
                85                  90                  95      


Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 
            100                 105                 110         


Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 
        115                 120                 125             


Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 
    130                 135                 140                 


Val Gly Gly Ser Thr Leu Cys Val Arg Arg Ala Pro Pro Thr Thr Ala 
145                 150                 155                 160 


Val Pro Ser Arg Thr Ser Leu Val Leu Thr Leu Asn Glu Leu 
                165                 170                 


<210>  8
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala 
145                 150                 155 


