                         SEQUENCE LISTING

<110>  SEATTLE CHILDREN'S HOSPITAL (dba Seattle Children's Research Institute)
 
<120>  HOMOLOGY DIRECTED REPAIR COMPOSITIONS FOR THE TREATMENT OF 
       HEMOGLOBINOPATHIES

<130>  SCRI-001-WO1

<140>  PCT/US2018/029235
<141>  2018-04-24

<150>  US 62/488,927
<151>  2017-04-24

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
cttgaccaat agccttgaca a                                                 21


<210>  2
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  2
gaccaatagc cttgac                                                       16


<210>  3
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  3
caatagcctt gac                                                          13


<210>  4
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  4
gaccaatagc                                                              10


<210>  5
<211>  5
<212>  DNA
<213>  Homo sapiens

<400>  5
ccaat                                                                    5


<210>  6
<211>  4
<212>  DNA
<213>  Homo sapiens

<400>  6
caat                                                                     4


<210>  7
<211>  2835
<212>  DNA
<213>  Homo sapiens

<400>  7
ctcaggatcc acatgcagct tgtcacagtg cagttcactc agctgggcaa aggtgccctt       60

gagatcatcc aggtgctttg tggcatctcc caaggaagtc agcaccttct tgccatgtgc      120

cttgactttg gggttgccca tgatggcaga ggcagaggac aggttgccaa agctgtcaaa      180

gaacctctgg gtccatgggt agacaaccag gagcctgtga gattgacaag aacagtttga      240

cagtcagaag gtgccacaaa tcctgagaag cgacctggac ttttgccagg cacagggtcc      300

ttccttccct cccttgtcct ggtcaccaga gcctaccttc ccagggtttc tcctccagca      360

tcttccacat tcaccttgcc ccacaggctt gtgatagtag ccttgtcctc ctctgtgaaa      420

tgacccatgg cgtctggact aggagcttat tgataacctc agacgttcca gaagcgagtg      480

tgtggaactg ctgaagggtg cttcctttta ttcttcatcc ctagccagcc gccggcccct      540

ggcctcactg gatactctaa gactattggt caagtttgcc ttgtcaaggc tattggtcaa      600

ggcaaggctg gccaacccat gggtggagtt tagccaggga ccgtttcaga cagatatttg      660

cattgagata gtgtggggaa ggggccccca agaggatact gctaattttt tttatagcct      720

ttgccttgtt ccgattcagt cattccagtt tttctctaat ttattcttcc ctttagctag      780

tttccttctc ccatcataga ggataccagg acttcttttg tcagccgttt tttaccttct      840

tgtctctagc tccagtgagg cctgtagttt aaagctaaag catgtaccaa tttttgaaaa      900

gttcagggat tgtgaaatgt gttttaggca taggtccagg atttttgacg ggacaaatct      960

tagtctcttt cagttagcag tggtttctaa ggaaaaagtg ctatacttct ttttgaatat     1020

actctttgtg acttttgcca ttatctctta atttctcaat agtgcagtga aaacaatttc     1080

tataaagcca cagtttcagc gcagtaatag attagtgtta cataatataa gacctaatgc     1140

ttacctcaat atctacttat ccgtacctat ttgaaataaa tcatgactgt ttcatcttag     1200

aaaaatattt gattccatat tcaggtatgt atgtatacac cagatgatgt gtatttacca     1260

ctggataagt gtgtgtgctg gctgatgacc cagggttttg gcgtagctct tctatgctca     1320

gtaaagatga tggtagaatg ttctttggca ggtactgtgg attagaatta attatcttgt     1380

ataaatgcta ggttcacttc tcagggaatc ttactctaag acataagatg tgcgtgtaca     1440

tggaaaacaa ctctaaagag gcaagggttg tttttattga ctaatagtcc acacactatt     1500

ataactcgaa tattagtgta ctttagacag ctttatttct aacacagtgc tgtttctgac     1560

atattggacc attaacaggg taggaagtat ttatggtggt tttttggttc tgttttgctt     1620

ttggttagtt tgtttttgtt tttctctgaa agtgatccat gatctctaac cttgctagat     1680

tataatgcca gaagctctgg aattctggct tatcggaggc aagctgtatc ttcaaattag     1740

tttatcccct aagctatcag gttgattgaa attattataa tattggtgaa attctttcat     1800

ccttcatgat cctgtgtaaa gcttatatct gctcattgat acagatggct aaaaggccag     1860

aaagacacac atttacccat gtaacaagcc tgcacatcct gcacatgtac cttcgaaatt     1920

aaaatgaaat gaaataaaat taaaaggaaa aaaatgccat ggcaacatca ggaagttatc     1980

ttttatggtc taaaaatggg cagcataaat aatctacccc ttgtttagca tactattgaa     2040

aaataacaat aaaaatcggc aaccagtagc ccttgcgtct actctgccta tgaagtagcc     2100

attcatttat tccttcaatt ttttataaac ttgttttact aaaaaaaaaa aggacaaaga     2160

aagaaagtgc gaattgtgaa atggtagtga gtgatggcat ttgaagtggg tcctttatga     2220

tttgatggag ccaggcagaa gacgtttgga gaaagaagtt cctgaaagta ggaagggcat     2280

gtggaaaact ctgaggctga ggaaaaaaaa gaaagaaaga aatataaaga aagaacttga     2340

catttcactg tatataaaca cattacaagc ctaaagtacg ttgaagaaaa aatagaattc     2400

aaagttagac agaagggctc aggcttacta tttgcatctt acagatgaga gtagtagagt     2460

tggtatttta ttctgaaaca cagaggacaa gtggagattt gtaaacctga gataaacatg     2520

gtttctaatc cactgaacac cgaagcttat ttttttctct ttcttcatct gccttactta     2580

gtgcaaggtg ctataacaaa atagcataga ctgggtgact tcaacaacag gattttttct     2640

cacttttctg ctggttcctg gtcagggctc tcttcctggg ttgcaggtgg ctgacttccc     2700

actgtgtcct caccagaagg aagagaaatg gctaatctct ctgcttctga tgaggaaaat     2760

aattctatga tggggatctg ctctcatgag ctcctctaaa cctgattact tttccaaagc     2820

ctcccccaca aatgg                                                      2835


<210>  8
<211>  2835
<212>  DNA
<213>  Homo sapiens

<400>  8
ccatttgtgg gggaggcttt ggaaaagtaa tcaggtttag aggagctcat gagagcagat       60

ccccatcata gaattatttt cctcatcaga agcagagaga ttagccattt ctcttccttc      120

tggtgaggac acagtgggaa gtcagccacc tgcaacccag gaagagagcc ctgaccagga      180

accagcagaa aagtgagaaa aaatcctgtt gttgaagtca cccagtctat gctattttgt      240

tatagcacct tgcactaagt aaggcagatg aagaaagaga aaaaaataag cttcggtgtt      300

cagtggatta gaaaccatgt ttatctcagg tttacaaatc tccacttgtc ctctgtgttt      360

cagaataaaa taccaactct actactctca tctgtaagat gcaaatagta agcctgagcc      420

cttctgtcta actttgaatt ctattttttc ttcaacgtac tttaggcttg taatgtgttt      480

atatacagtg aaatgtcaag ttctttcttt atatttcttt ctttcttttt tttcctcagc      540

ctcagagttt tccacatgcc cttcctactt tcaggaactt ctttctccaa acgtcttctg      600

cctggctcca tcaaatcata aaggacccac ttcaaatgcc atcactcact accatttcac      660

aattcgcact ttctttcttt gtcctttttt tttttagtaa aacaagttta taaaaaattg      720

aaggaataaa tgaatggcta cttcataggc agagtagacg caagggctac tggttgccga      780

tttttattgt tatttttcaa tagtatgcta aacaaggggt agattattta tgctgcccat      840

ttttagacca taaaagataa cttcctgatg ttgccatggc atttttttcc ttttaatttt      900

atttcatttc attttaattt cgaaggtaca tgtgcaggat gtgcaggctt gttacatggg      960

taaatgtgtg tctttctggc cttttagcca tctgtatcaa tgagcagata taagctttac     1020

acaggatcat gaaggatgaa agaatttcac caatattata ataatttcaa tcaacctgat     1080

agcttagggg ataaactaat ttgaagatac agcttgcctc cgataagcca gaattccaga     1140

gcttctggca ttataatcta gcaaggttag agatcatgga tcactttcag agaaaaacaa     1200

aaacaaacta accaaaagca aaacagaacc aaaaaaccac cataaatact tcctaccctg     1260

ttaatggtcc aatatgtcag aaacagcact gtgttagaaa taaagctgtc taaagtacac     1320

taatattcga gttataatag tgtgtggact attagtcaat aaaaacaacc cttgcctctt     1380

tagagttgtt ttccatgtac acgcacatct tatgtcttag agtaagattc cctgagaagt     1440

gaacctagca tttatacaag ataattaatt ctaatccaca gtacctgcca aagaacattc     1500

taccatcatc tttactgagc atagaagagc tacgccaaaa ccctgggtca tcagccagca     1560

cacacactta tccagtggta aatacacatc atctggtgta tacatacata cctgaatatg     1620

gaatcaaata tttttctaag atgaaacagt catgatttat ttcaaatagg tacggataag     1680

tagatattga ggtaagcatt aggtcttata ttatgtaaca ctaatctatt actgcgctga     1740

aactgtggct ttatagaaat tgttttcact gcactattga gaaattaaga gataatggca     1800

aaagtcacaa agagtatatt caaaaagaag tatagcactt tttccttaga aaccactgct     1860

aactgaaaga gactaagatt tgtcccgtca aaaatcctgg acctatgcct aaaacacatt     1920

tcacaatccc tgaacttttc aaaaattggt acatgcttta gctttaaact acaggcctca     1980

ctggagctag agacaagaag gtaaaaaacg gctgacaaaa gaagtcctgg tatcctctat     2040

gatgggagaa ggaaactagc taaagggaag aataaattag agaaaaactg gaatgactga     2100

atcggaacaa ggcaaaggct ataaaaaaaa ttagcagtat cctcttgggg gccccttccc     2160

cacactatct caatgcaaat atctgtctga aacggtccct ggctaaactc cacccatggg     2220

ttggccagcc ttgccttgac caatagcctt gacaaggcaa acttgaccaa tagtcttaga     2280

gtatccagtg aggccagggg ccggcggctg gctagggatg aagaataaaa ggaagcaccc     2340

ttcagcagtt ccacacactc gcttctggaa cgtctgaggt tatcaataag ctcctagtcc     2400

agacgccatg ggtcatttca cagaggagga caaggctact atcacaagcc tgtggggcaa     2460

ggtgaatgtg gaagatgctg gaggagaaac cctgggaagg taggctctgg tgaccaggac     2520

aagggaggga aggaaggacc ctgtgcctgg caaaagtcca ggtcgcttct caggatttgt     2580

ggcaccttct gactgtcaaa ctgttcttgt caatctcaca ggctcctggt tgtctaccca     2640

tggacccaga ggttctttga cagctttggc aacctgtcct ctgcctctgc catcatgggc     2700

aaccccaaag tcaaggcaca tggcaagaag gtgctgactt ccttgggaga tgccacaaag     2760

cacctggatg atctcaaggg cacctttgcc cagctgagtg aactgcactg tgacaagctg     2820

catgtggatc ctgag                                                      2835


<210>  9
<211>  1000
<212>  DNA
<213>  Homo sapiens

<400>  9
gtcaataaaa acaacccttg cctctttaga gttgttttcc atgtacacgc acatcttatg       60

tcttagagta agattccctg agaagtgaac ctagcattta tacaagataa ttaattctaa      120

tccacagtac ctgccaaaga acattctacc atcatcttta ctgagcatag aagagctacg      180

ccaaaaccct gggtcatcag ccagcacaca cacttatcca gtggtaaata cacatcatct      240

ggtgtataca tacatacctg aatatggaat caaatatttt tctaagatga aacagtcatg      300

atttatttca aataggtacg gataagtaga tattgaggta agcattaggt cttatattat      360

gtaacactaa tctattactg cgctgaaact gtggctttat agaaattgtt ttcactgcac      420

tattgagaaa ttaagagata atggcaaaag tcacaaagag tatattcaaa aagaagtata      480

gcactttttc cttagaaacc actgctaact gaaagagact aagatttgtc ccgtcaaaaa      540

tcctggacct atgcctaaaa cacatttcac aatccctgaa cttttcaaaa attggtacat      600

gctttagctt taaactacag gcctcactgg agctagagac aagaaggtaa aaaacggctg      660

acaaaagaag tcctggtatc ctctatgatg ggagaaggaa actagctaaa gggaagaata      720

aattagagaa aaactggaat gactgaatcg gaacaaggca aaggctataa aaaaaattag      780

cagtatcctc ttgggggccc cttccccaca ctatctcaat gcaaatatct gtctgaaacg      840

gtccctggct aaactccacc catgggttgg ccagccttgc cttgaccaat agccttgaca      900

aggcaaactt gaccaatagt cttagagtat ccagtgaggc caggggccgg cggctggcta      960

gggatgaaga ataaaaggaa gcacccttca gcagttccac                           1000


<210>  10
<211>  7210
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  10
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtcata      180

aatacttcct accctgttaa tggtccaata tgtcagaaac agcactgtgt tagaaataaa      240

gctgtctaaa gtacactaat attcgagtta taatagtgtg tggactatta gtcaataaaa      300

acaacccttg cctctttaga gttgttttcc atgtacacgc acatcttatg tcttagagta      360

agattccctg agaagtgaac ctagcattta tacaagataa ttaattctaa tccacagtac      420

ctgccaaaga acattctacc atcatcttta ctgagcatag aagagctacg ccaaaaccct      480

gggtcatcag ccagcacaca cacttatcca gtggtaaata cacatcatct ggtgtataca      540

tacatacctg aatatggaat caaatatttt tctaagatga aacagtcatg atttatttca      600

aataggtacg gataagtaga tattgaggta agcattaggt cttatattat gtaacactaa      660

tctattactg cgctgaaact gtggctttat agaaattgtt ttcactgcac tattgagaaa      720

ttaagagata atggcaaaag tcacaaagag tatattcaaa aagaagtata gcactttttc      780

cttagaaacc actgctaact gaaagagact aagatttgtc ccgtcaaaaa tcctggacct      840

atgcctaaaa cacatttcac aatccctgaa cttttcaaaa attggtacat gctttagctt      900

taaactacag gcctcactgg agctagagac aagaaggtaa aaaacggctg acaaaagaag      960

tcctggtatc ctctatgatg ggagaaggaa actagctaaa gggaagaata aattagagaa     1020

aaactggaat gactgaatcg gaacaaggca aaggctataa aaaaaattaa gcagcagtat     1080

cctcttgggg gccccttccc cacactatct caatgcaaat atctgtctga aacggtccct     1140

ggctaaactc cacccatggg ttggccagcc ttgccttgac gaacagagaa acaggagaat     1200

atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag     1260

ttggaacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct     1320

cagggccaag aacagatggt ccccagatgc ggtcccgccc tcagcagttt ctagagaacc     1380

atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa     1440

ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct ctatataagc     1500

agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacttc     1560

catagaagga tctcgaggcc accatggtga gcaagggcga ggagctgttc accggggtgg     1620

tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg     1680

agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca     1740

agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca     1800

gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct     1860

acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg     1920

tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg     1980

aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata     2040

tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg     2100

aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc     2160

ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca     2220

acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg     2280

gcatggacga gctgtacaag taaactagtg tcgactgctt tatttgtgaa atttgtgatg     2340

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     2400

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaaca atagccttga     2460

caaggcaaac ttgaccaata gtcttagagt atccagtgag gccaggggcc ggcggctggc     2520

tagggatgaa gaataaaagg aagcaccctt cagcagttcc acacactcgc ttctggaacg     2580

tctgaggtta tcaataagct cctagtccag acgccatggg tcatttcaca gaggaggaca     2640

aggctactat cacaagcctg tggggcaagg tgaatgtgga agatgctgga ggagaaaccc     2700

tgggaaggta ggctctggtg accaggacaa gggagggaag gaaggaccct gtgcctggca     2760

aaagtccagg tcgcttctca ggatttgtgg caccttctga ctgtcaaact gttcttgtca     2820

atctcacagg ctcctggttg tctacccatg gacccagagg ttctttgaca gctttggcaa     2880

cctgtcctct gcctctgcca tcatgggcaa ccccaaagtc aaggcacatg gcaagaaggt     2940

gctgacttcc ttgggagatg ccacaaagca cctggatgat ctcaagggca cctttgccca     3000

gctgagtgaa ctgcactgtg acaagctgca tgtggatcct gagaacttca aggtgagtcc     3060

aggagatgtt tcagccctgt tgcctttagt ctcgaggcaa cttagacaac tgagtattga     3120

tctgagcaca gcagggtgtg agctgtttga agatactggg gttgggggtg aagaaactgc     3180

agaggactaa ctgggctgag acccagtggt aatgttttag ggcctaagga gcgcctctaa     3240

aaatctagat ggacaatttt gactttgaga aaagagaggt ggaaatgagg aaaatgactt     3300

ttctttatta gattccagta gaaagaactt tcatctttcc ctcatttttg ttgttttaaa     3360

acatctatct ggaggcagga caagtatggt cgttaaaaag atgcaggcag aaggcatata     3420

ttggctcagt caaagtgggg aactttgggc tagagtagat aagtagcatg gcgggttaat     3480

cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     3540

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     3600

agtgagcgag cgagcgcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt     3660

cccaacagtt gcgcagcctg aatggcgaat ggcgattccg ttgcaatggc tggcggtaat     3720

attgttctgg atattaccag caaggccgat agtttgagtt cttctactca ggcaagtgat     3780

gttattacta atcaaagaag tattgcgaca acggttaatt tgcgtgatgg acagactctt     3840

ttactcggtg gcctcactga ttataaaaac acttctcagg attctggcgt accgttcctg     3900

tctaaaatcc ctttaatcgg cctcctgttt agctcccgct ctgattctaa cgaggaaagc     3960

acgttatacg tgctcgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc     4020

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     4080

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     4140

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     4200

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     4260

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     4320

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg     4380

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt     4440

tacaatttaa atatttgctt atacaatctt cctgtttttg gggcttttct gattatcaac     4500

cggggtacat atgattgaca tgctagtttt acgattaccg ttcatcgatt ctcttgtttg     4560

ctccagactc tcaggcaatg acctgatagc ctttgtagag acctctcaaa aatagctacc     4620

ctctccggca tgaatttatc agctagaacg gttgaatatc atattgatgg tgatttgact     4680

gtctccggcc tttctcaccc gtttgaatct ttacctacac attactcagg cattgcattt     4740

aaaatatatg agggttctaa aaatttttat ccttgcgttg aaataaaggc ttctcccgca     4800

aaagtattac agggtcataa tgtttttggt acaaccgatt tagctttatg ctctgaggct     4860

ttattgctta attttgctaa ttctttgcct tgcctgtatg atttattgga tgttggaatc     4920

gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca     4980

ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac     5040

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     5100

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     5160

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     5220

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     5280

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     5340

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     5400

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     5460

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     5520

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     5580

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     5640

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     5700

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     5760

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     5820

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     5880

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     5940

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     6000

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     6060

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     6120

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     6180

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     6240

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     6300

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     6360

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     6420

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     6480

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc     6540

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     6600

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     6660

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     6720

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     6780

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     6840

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     6900

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     6960

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     7020

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     7080

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     7140

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga     7200

ttcattaatg                                                            7210


<210>  11
<211>  7204
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  11
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgcataa      180

atacttccta ccctgttaat ggtccaatat gtcagaaaca gcactgtgtt agaaataaag      240

ctgtctaaag tacactaata ttcgagttat aatagtgtgt ggactattag tcaataaaaa      300

caacccttgc ctctttagag ttgttttcca tgtacacgca catcttatgt cttagagtaa      360

gattccctga gaagtgaacc tagcatttat acaagataat taattctaat ccacagtacc      420

tgccaaagaa cattctacca tcatctttac tgagcataga agagctacgc caaaaccctg      480

ggtcatcagc cagcacacac acttatccag tggtaaatac acatcatctg gtgtatacat      540

acatacctga atatggaatc aaatattttt ctaagatgaa acagtcatga tttatttcaa      600

ataggtacgg ataagtagat attgaggtaa gcattaggtc ttatattatg taacactaat      660

ctattactgc gctgaaactg tggctttata gaaattgttt tcactgcact attgagaaat      720

taagagataa tggcaaaagt cacaaagagt atattcaaaa agaagtatag cactttttcc      780

ttagaaacca ctgctaactg aaagagacta agatttgtcc cgtcaaaaat cctggaccta      840

tgcctaaaac acatttcaca atccctgaac ttttcaaaaa ttggtacatg ctttagcttt      900

aaactacagg cctcactgga gctagagaca agaaggtaaa aaacggctga caaaagaagt      960

cctggtatcc tctatgatgg gagaaggaaa ctagctaaag ggaagaataa attagagaaa     1020

aactggaatg actgaatcgg aacaaggcaa aggctataaa aaaaattaag cagcagtatc     1080

ctcttggggg ccccttcccc acactatctc aatgcaaata tctgtctgaa acggtccctg     1140

gctaaactcc acccatgggt tggccagcct tgccttgacg aacagagaaa caggagaata     1200

tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacagt     1260

tggaacagca gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc     1320

agggccaaga acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca     1380

tcagatgttt ccagggtgcc ccaaggacct gaaatgaccc tgtgccttat ttgaactaac     1440

caatcagttc gcttctcgct tctgttcgcg cgcttctgct ccccgagctc tatataagca     1500

gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacttcc     1560

atagaaggat ctcgaggcca ccatggtgag caagggcgag gagctgttca ccggggtggt     1620

gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga     1680

gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa     1740

gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag     1800

ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta     1860

cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt     1920

gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga     1980

ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat     2040

catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga     2100

ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc     2160

cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa     2220

cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg     2280

catggacgag ctgtacaagt aaactagtgt cgactgcttt atttgtgaaa tttgtgatgc     2340

tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat     2400

tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaaaac ttcaaggtga     2460

gtccaggaga tgtttcagcc ctgttgcctt tagtctcgag gcaacttaga caactgagta     2520

ttgatctgag cacagcaggg tgtgagctgt ttgaagatac tggggttggg ggtgaagaaa     2580

ctgcagagga ctaactgggc tgagacccag tggtaatgtt ttagggccta aggagcgcct     2640

ctaaaaatct agatggacaa ttttgacttt gagaaaagag aggtggaaat gaggaaaatg     2700

acttttatta gattccagta gaaagaactt tcatctttcc ctcatttttg ttgttttaaa     2760

acatctatct ggaggcagga caagtatggt cgttaaaaag atgcaggcag aaggcatata     2820

ttggctcagt caaagtgggg aactttggtg gccaaacata cattgctaag gctattccta     2880

tatcagctgg acacatataa aatgctgcta atgcttcatt acaaacttat atcctttaat     2940

tccagatggg ggcaaagtat gtccaggggt gaggaacaat tgaaacattt gggctggagt     3000

agattttgaa agtcagctct gtgtgtgtgt gtgtgtgcgc gcgcgcgtgt gtgtgtgtgt     3060

gtgtcagcgt gtgtttcttt taacgtcttc agcctacaac atacagggtt catggtggca     3120

agaagatagc aagatttaaa ttatggccag tgactagtgc ttgaagggga acaactacct     3180

gcatttaatg ggaaggcaaa atctcaggct ttgagggaag ttaacatagg cttgattctg     3240

ggtagaagct gggtgtgtag ttatctggag gccaggctgg agctctcagc tcactatggg     3300

ttcatcttta ttgtctcctt tcatctcaac agctcctggg aaatgtgctg gtgaccgttt     3360

tggcaatcca tttcggcaaa gaattcaccc ctgaggtgca ggcttcctgg cagaagatgg     3420

tgactgcagt ggccagtgcc ctgctagagt agataagtag catggcgggt taatcattaa     3480

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     3540

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     3600

cgagcgagcg cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac     3660

agttgcgcag cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt     3720

ctggatatta ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt     3780

actaatcaaa gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc     3840

ggtggcctca ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa     3900

atccctttaa tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta     3960

tacgtgctcg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg     4020

tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt     4080

cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg     4140

ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga     4200

ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac     4260

gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc     4320

tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa     4380

aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat     4440

ttaaatattt gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt     4500

acatatgatt gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag     4560

actctcaggc aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc     4620

ggcatgaatt tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc     4680

ggcctttctc acccgtttga atctttacct acacattact caggcattgc atttaaaata     4740

tatgagggtt ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta     4800

ttacagggtc ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg     4860

cttaattttg ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga     4920

tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca     4980

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg     5040

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     5100

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     5160

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt     5220

caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     5280

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     5340

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     5400

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     5460

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     5520

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     5580

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     5640

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     5700

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     5760

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     5820

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     5880

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     5940

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     6000

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     6060

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     6120

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     6180

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     6240

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     6300

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     6360

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     6420

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     6480

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     6540

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     6600

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     6660

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     6720

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     6780

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     6840

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     6900

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     6960

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     7020

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     7080

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     7140

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     7200

aatg                                                                  7204


<210>  12
<211>  8236
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  12
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatcttaccc tgttaatggt ccaatatgtc agaaacagca      180

ctgtgttaga aataaagctg tctaaagtac actaatattc gagttataat agtgtgtgga      240

ctattagtca ataaaaacaa cccttgcctc tttagagttg ttttccatgt acacgcacat      300

cttatgtctt agagtaagat tccctgagaa gtgaacctag catttataca agataattaa      360

ttctaatcca cagtacctgc caaagaacat tctaccatca tctttactga gcatagaaga      420

gctacgccaa aaccctgggt catcagccag cacacacact tatccagtgg taaatacaca      480

tcatctggtg tatacataca tacctgaata tggaatcaaa tatttttcta agatgaaaca      540

gtcatgattt atttcaaata ggtacggata agtagatatt gaggtaagca ttaggtctta      600

tattatgtaa cactaatcta ttactgcgct gaaactgtgg ctttatagaa attgttttca      660

ctgcactatt gagaaattaa gagataatgg caaaagtcac aaagagtata ttcaaaaaga      720

agtatagcac tttttcctta gaaaccactg ctaactgaaa gagactaaga tttgtcccgt      780

caaaaatcct ggacctatgc ctaaaacaca tttcacaatc cctgaacttt tcaaaaattg      840

gtacatgctt tagctttaaa ctacaggcct cactggagct agagacaaga aggtaaaaaa      900

cggctgacaa aagaagtcct ggtatcctct atgatgggag aaggaaacta gctaaaggga      960

agaataaatt agagaaaaac tggaatgact gaatcggaac aaggcaaagg ctataaaaaa     1020

aattagcagt atcctcttgg gggccccttc cccacactat ctcaatgcaa atatctgtct     1080

gaaacggtcc ctggctaaac tccacccatg ggttggccag ccttgccttg accaatagcc     1140

ttgacgaatt cgctttaaaa aacctcccac atctccccct gaacctgaaa cataaaatga     1200

atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata     1260

gcatcacaaa tttcacaaat aaagcttact tgtacagctc gtccatgccg agagtgatcc     1320

cggcggcggt cacgaactcc agcaggacca tgtgatcgcg cttctcgttg gggtctttgc     1380

tcagggcgga ctgggtgctc aggtagtggt tgtcgggcag cagcacgggg ccgtcgccga     1440

tgggggtgtt ctgctggtag tggtcggcga gctgcacgct gccgtcctcg atgttgtggc     1500

ggatcttgaa gttcaccttg atgccgttct tctgcttgtc ggccatgata tagacgttgt     1560

ggctgttgta gttgtactcc agcttgtgcc ccaggatgtt gccgtcctcc ttgaagtcga     1620

tgcccttcag ctcgatgcgg ttcaccaggg tgtcgccctc gaacttcacc tcggcgcggg     1680

tcttgtagtt gccgtcgtcc ttgaagaaga tggtgcgctc ctggacgtag ccttcgggca     1740

tggcggactt gaagaagtcg tgctgcttca tgtggtcggg gtagcggctg aagcactgca     1800

cgccgtaggt cagggtggtc acgagggtgg gccagggcac gggcagcttg ccggtggtgc     1860

agatgaactt cagggtcagc ttgccgtagg tggcatcgcc ctcgccctcg ccggacacgc     1920

tgaacttgtg gccgtttacg tcgccgtcca gctcgaccag gatgggcacc accccggtga     1980

acagctcctc gcccttgctc accatggtgg cggcgcggcc gcgatctgac ggttcactaa     2040

acgagctctg cttatataga gctcggggag cagaagcgcg cgaacagaag cgagaagcga     2100

actgattggt tagttcaaat aaggcacagg gtcatttcag gtccttgggg caccctggaa     2160

acatctgatg gttctctaga aactgctgag ggcgggaccg catctgggga ccatctgttc     2220

ttggccctga gccggggcag gaactgctta ccacagatat cctgtttggc ccatattctg     2280

ctgttccaac tgttcttggc cctgagccgg ggcaggaact gcttaccaca gatatcctgt     2340

ttggcccata ttctcctgtt tctctgttcc cgcggcgaga tcgagaccat cctggctaac     2400

acagtgaaac cccgtctcta ctaaaaaaat acaaaaaatt agccgggctt ggtggcgggt     2460

gcctgtagtc ccagctacta tggaggctga ggcgggagaa tggcgtgaac gcggggggcg     2520

gagcttgcag tgagcagaga tcaggggcca ctgcactcca gcctgggcga cagagagaga     2580

ctctgtctca aaaaaaagaa aaaaaaaatt tagtagacta gctaaaaaaa tccagagata     2640

gttattgatg catatgtaaa agtcttccaa tatttacaag tacaatgaaa aaaaaataac     2700

cttgaattaa gtgtagaact cattgacaat gtttcaaagg atgtgaggga taaactaaaa     2760

tttgggcagt acatgctgtt cctgtgtact tggaacagag ggagaaaatc tgggctggaa     2820

atattgttat aggagttagc acatgaaggt gacaactaaa ttatttggag tagatggagt     2880

caccagcaca tgtgaatagt tttagaatga aatgacccaa gatagaactt tggagagccc     2940

ccaaatttaa ataaaatcag tataagagaa gaggaagaaa ccaaatggta tactagtcta     3000

aattgtttct tagtgacaaa agaataacct gaatattaga ttagctgcct atatgctctc     3060

tgaatcaatt tcattcaaca tgcaacagtt ctggaaccta tcagggacca cagtcagcca     3120

ggcaagcaca tctgcccaag ccaagggtgg aggcatgcag ctgtgggggt ctgtgaaaac     3180

acttgaggga gcagataact gggccaacca tgactcagtg cttctggagg ccaacaggac     3240

tgctgagtca tcctgtgggg gtggaggtgg gacaagggaa aggggtgaat ggtactgctg     3300

attacaacct ctggtgctgc ctccccctcc tgtttatctg agagaggcct cactggagct     3360

agagacaaga aggtaaaaaa cggctgacaa aagaagtcct ggtatcctct atgatgggag     3420

aaggaaacta gctaaaggga agaataaatt agagaaaaac tggaatgact gaatcggaac     3480

aaggcaaagg ctataaaaaa aattagcagt atcctcttgg gggccccttc cccacactat     3540

ctcaatgcaa atatctgtct gaaacggtcc ctggctaaac tccacccatg ggttggccag     3600

ccttgccttg acaaggcaaa cttgaccaat agtcttagag tatccagtga ggccaggggc     3660

cggcggctgg ctagggatga agaataaaag gaagcaccct tcagcagttc cacacactcg     3720

cttctggaac gtctgaggtt atcaataagc tcctagtcca gacgccatgg gtcatttcac     3780

agaggaggac aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg     3840

aggagaaacc ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc     3900

tgtgcctggc aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac     3960

tgttcttgtc aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac     4020

agctttggca acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat     4080

ggcaagaagg tgctgacttc cttgggagat gccacaaagc acctggatga tctcaagggc     4140

acctttgccc agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc     4200

aaggtgagtc caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa     4260

cggagtattg atctgagcac agcagggtgt gagctgtttg aagatactgg ggttgggggt     4320

gaagaaactg cagaggacta actgggctga gacccagtgg taatgtttta gggcctaagg     4380

agtgcctcta aaaatctaga tggacaattt tgactttgag aaaagagagg tggaaatgag     4440

gaaaatgact tttctttatt agattccagt agaaagaact ttcatctttc cctcattttt     4500

gttgttttaa aagtcgacag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4560

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4620

cggcctcagt gagcgagcga gcgcgcagct ggcgtaatag cgaagaggcc cgcaccgatc     4680

gcccttccca acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc     4740

ggtaatattg ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca     4800

agtgatgtta ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag     4860

actcttttac tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg     4920

ttcctgtcta aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag     4980

gaaagcacgt tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt     5040

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     5100

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     5160

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     5220

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     5280

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     5340

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     5400

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     5460

aacgtttaca atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt     5520

atcaaccggg gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct     5580

tgtttgctcc agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata     5640

gctaccctct ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat     5700

ttgactgtct ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt     5760

gcatttaaaa tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct     5820

cccgcaaaag tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct     5880

gaggctttat tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt     5940

ggaatcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat     6000

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc     6060

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     6120

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     6180

cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg     6240

tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     6300

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     6360

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     6420

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     6480

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     6540

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     6600

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     6660

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     6720

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     6780

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     6840

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     6900

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     6960

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     7020

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     7080

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     7140

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     7200

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     7260

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     7320

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     7380

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     7440

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     7500

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     7560

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     7620

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     7680

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     7740

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     7800

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     7860

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     7920

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     7980

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     8040

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     8100

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     8160

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt     8220

ggccgattca ttaatg                                                     8236


<210>  13
<211>  7955
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  13
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatcttaccc tgttaatggt ccaatatgtc agaaacagca      180

ctgtgttaga aataaagctg tctaaagtac actaatattc gagttataat agtgtgtgga      240

ctattagtca ataaaaacaa cccttgcctc tttagagttg ttttccatgt acacgcacat      300

cttatgtctt agagtaagat tccctgagaa gtgaacctag catttataca agataattaa      360

ttctaatcca cagtacctgc caaagaacat tctaccatca tctttactga gcatagaaga      420

gctacgccaa aaccctgggt catcagccag cacacacact tatccagtgg taaatacaca      480

tcatctggtg tatacataca tacctgaata tggaatcaaa tatttttcta agatgaaaca      540

gtcatgattt atttcaaata ggtacggata agtagatatt gaggtaagca ttaggtctta      600

tattatgtaa cactaatcta ttactgcgct gaaactgtgg ctttatagaa attgttttca      660

ctgcactatt gagaaattaa gagataatgg caaaagtcac aaagagtata ttcaaaaaga      720

agtatagcac tttttcctta gaaaccactg ctaactgaaa gagactaaga tttgtcccgt      780

caaaaatcct ggacctatgc ctaaaacaca tttcacaatc cctgaacttt tcaaaaattg      840

gtacatgctt tagctttaaa ctacgaattc gctttaaaaa acctcccaca tctccccctg      900

aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat      960

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcttactt gtacagctcg     1020

tccatgccga gagtgatccc ggcggcggtc acgaactcca gcaggaccat gtgatcgcgc     1080

ttctcgttgg ggtctttgct cagggcggac tgggtgctca ggtagtggtt gtcgggcagc     1140

agcacggggc cgtcgccgat gggggtgttc tgctggtagt ggtcggcgag ctgcacgctg     1200

ccgtcctcga tgttgtggcg gatcttgaag ttcaccttga tgccgttctt ctgcttgtcg     1260

gccatgatat agacgttgtg gctgttgtag ttgtactcca gcttgtgccc caggatgttg     1320

ccgtcctcct tgaagtcgat gcccttcagc tcgatgcggt tcaccagggt gtcgccctcg     1380

aacttcacct cggcgcgggt cttgtagttg ccgtcgtcct tgaagaagat ggtgcgctcc     1440

tggacgtagc cttcgggcat ggcggacttg aagaagtcgt gctgcttcat gtggtcgggg     1500

tagcggctga agcactgcac gccgtaggtc agggtggtca cgagggtggg ccagggcacg     1560

ggcagcttgc cggtggtgca gatgaacttc agggtcagct tgccgtaggt ggcatcgccc     1620

tcgccctcgc cggacacgct gaacttgtgg ccgtttacgt cgccgtccag ctcgaccagg     1680

atgggcacca ccccggtgaa cagctcctcg cccttgctca ccatggtggc ggcgcggccg     1740

cgatctgacg gttcactaaa cgagctctgc ttatatagag ctcggggagc agaagcgcgc     1800

gaacagaagc gagaagcgaa ctgattggtt agttcaaata aggcacaggg tcatttcagg     1860

tccttggggc accctggaaa catctgatgg ttctctagaa actgctgagg gcgggaccgc     1920

atctggggac catctgttct tggccctgag ccggggcagg aactgcttac cacagatatc     1980

ctgtttggcc catattctgc tgttccaact gttcttggcc ctgagccggg gcaggaactg     2040

cttaccacag atatcctgtt tggcccatat tctcctgttt ctctgttccc gcggcgagat     2100

cgagaccatc ctggctaaca cagtgaaacc ccgtctctac taaaaaaata caaaaaatta     2160

gccgggcttg gtggcgggtg cctgtagtcc cagctactat ggaggctgag gcgggagaat     2220

ggcgtgaacg cggggggcgg agcttgcagt gagcagagat caggggccac tgcactccag     2280

cctgggcgac agagagagac tctgtctcaa aaaaaagaaa aaaaaaattt agtagactag     2340

ctaaaaaaat ccagagatag ttattgatgc atatgtaaaa gtcttccaat atttacaagt     2400

acaatgaaaa aaaaataacc ttgaattaag tgtagaactc attgacaatg tttcaaagga     2460

tgtgagggat aaactaaaat ttgggcagta catgctgttc ctgtgtactt ggaacagagg     2520

gagaaaatct gggctggaaa tattgttata ggagttagca catgaaggtg acaactaaat     2580

tatttggagt agatggagtc accagcacat gtgaatagtt ttagaatgaa atgacccaag     2640

atagaacttt ggagagcccc caaatttaaa taaaatcagt ataagagaag aggaagaaac     2700

caaatggtat actagtctaa attgtttctt agtgacaaaa gaataacctg aatattagat     2760

tagctgccta tatgctctct gaatcaattt cattcaacat gcaacagttc tggaacctat     2820

cagggaccac agtcagccag gcaagcacat ctgcccaagc caagggtgga ggcatgcagc     2880

tgtgggggtc tgtgaaaaca cttgagggag cagataactg ggccaaccat gactcagtgc     2940

ttctggaggc caacaggact gctgagtcat cctgtggggg tggaggtggg acaagggaaa     3000

ggggtgaatg gtactgctga ttacaacctc tggtgctgcc tccccctcct gtttatctga     3060

gagaggcctc actggagcta gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg     3120

gtatcctcta tgatgggaga aggaaactag ctaaagggaa gaataaatta gagaaaaact     3180

ggaatgactg aatcggaaca aggcaaaggc tataaaaaaa attagcagta tcctcttggg     3240

ggccccttcc ccacactatc tcaatgcaaa tatctgtctg aaacggtccc tggctaaact     3300

ccacccatgg gttggccagc cttgccttga caaggcaaac ttgaccaata gtcttagagt     3360

atccagtgag gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctt     3420

cagcagttcc acacactcgc ttctggaacg tctgaggtta tcaataagct cctagtccag     3480

acgccatggg tcatttcaca gaggaggaca aggctactat cacaagcctg tggggcaagg     3540

tgaatgtgga agatgctgga ggagaaaccc tgggaaggta ggctctggtg accaggacaa     3600

gggagggaag gaaggaccct gtgcctggca aaagtccagg tcgcttctca ggatttgtgg     3660

caccttctga ctgtcaaact gttcttgtca atctcacagg ctcctggttg tctacccatg     3720

gacccagagg ttctttgaca gctttggcaa cctgtcctct gcctctgcca tcatgggcaa     3780

ccccaaagtc aaggcacatg gcaagaaggt gctgacttcc ttgggagatg ccacaaagca     3840

cctggatgat ctcaagggca cctttgccca gctgagtgaa ctgcactgtg acaagctgca     3900

tgtggatcct gagaacttca aggtgagtcc aggagatgtt tcagccctgt tgcctttagt     3960

ctcgaggcaa cttagacaac ggagtattga tctgagcaca gcagggtgtg agctgtttga     4020

agatactggg gttgggggtg aagaaactgc agaggactaa ctgggctgag acccagtggt     4080

aatgttttag ggcctaagga gtgcctctaa aaatctagat ggacaatttt gactttgaga     4140

aaagagaggt ggaaatgagg aaaatgactt ttctttatta gattccagta gaaagaactt     4200

tcatctttcc ctcatttttg ttgttttaaa agtcgacagg aacccctagt gatggagttg     4260

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     4320

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg gcgtaatagc     4380

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcga     4440

ttccgttgca atggctggcg gtaatattgt tctggatatt accagcaagg ccgatagttt     4500

gagttcttct actcaggcaa gtgatgttat tactaatcaa agaagtattg cgacaacggt     4560

taatttgcgt gatggacaga ctcttttact cggtggcctc actgattata aaaacacttc     4620

tcaggattct ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc tgtttagctc     4680

ccgctctgat tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg     4740

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     4800

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     4860

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     4920

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     4980

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     5040

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     5100

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     5160

cgaattttaa caaaatatta acgtttacaa tttaaatatt tgcttataca atcttcctgt     5220

ttttggggct tttctgatta tcaaccgggg tacatatgat tgacatgcta gttttacgat     5280

taccgttcat cgattctctt gtttgctcca gactctcagg caatgacctg atagcctttg     5340

tagagacctc tcaaaaatag ctaccctctc cggcatgaat ttatcagcta gaacggttga     5400

atatcatatt gatggtgatt tgactgtctc cggcctttct cacccgtttg aatctttacc     5460

tacacattac tcaggcattg catttaaaat atatgagggt tctaaaaatt tttatccttg     5520

cgttgaaata aaggcttctc ccgcaaaagt attacagggt cataatgttt ttggtacaac     5580

cgatttagct ttatgctctg aggctttatt gcttaatttt gctaattctt tgccttgcct     5640

gtatgattta ttggatgttg gaatcgcctg atgcggtatt ttctccttac gcatctgtgc     5700

ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta     5760

agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg     5820

gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca     5880

ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt     5940

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     6000

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     6060

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     6120

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     6180

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     6240

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6300

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa     6360

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6420

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6480

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6540

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6600

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca     6660

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6720

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6780

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6840

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6900

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6960

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     7020

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     7080

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     7140

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     7200

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     7260

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac     7320

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7380

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7440

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7500

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7560

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7620

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7680

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7740

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7800

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7860

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7920

ccgcctctcc ccgcgcgttg gccgattcat taatg                                7955


<210>  14
<211>  8222
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  14
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgt atacatacat acctgaatat ggaatcaaat      180

atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg      240

aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc      300

tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca      360

aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag      420

agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc      480

ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta      540

gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga      600

aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca      660

aggcaaaggc tataaaaaaa attaagcagc agtatcctct tgggggcccc ttccccacac      720

tatctcaatg caaatatctg tctgaaacgg tccctggcta aactccaccc atgggttggc      780

cagccttgcc ttgacgctag cgtaaataca cttgcaaagg aggatgtttt tagtagcaat      840

ttgtactgat ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt      900

ccaactccta agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc      960

tcaccctgtg gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag     1020

gagccagggc tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga     1080

cacaactgtg ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag     1140

aagtctgccg ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc     1200

ctgggcaggt tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca     1260

tgtggagaca gagaagactc ttgggtttct gataggcact gactctctct gcctattggt     1320

ctattttccc acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc     1380

ctttggggat ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg     1440

caagaaagtg ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac     1500

ctttgcccag ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag     1560

ggtgagtcta tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg     1620

tcataggaag gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat     1680

ttgtaatttt aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa     1740

tactttccct aatctctttc tttcagggca ataatgatac aatgtatcat gcctctttgc     1800

accattctaa agaataacag tgataatttc tgggttaagg caatagcaat atttctgcat     1860

ataaatattt ctgcatataa attgtaactg atgtaagagg tttcatattg ctaatagcag     1920

ctacaatcca gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg     1980

agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacagctc     2040

ctgggcaacg tgctggtctg tgtgctggcc catcactttg gcaaagaatt caccccacca     2100

gtgcaggctg cctatcagaa agtggtggct ggtgtggcta atgccctggc ccacaagtat     2160

cactaagctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc     2220

aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa     2280

aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt actaaaaagg     2340

gaatgtggga ggttgcagtg ctagtctccc ggaactatca ctctttcaca gtctgctttg     2400

gaaggactgg gcttagtatg aaaagttagg actgagaaga atttgaaagg gggctttttg     2460

tagcttgata ttcactactg tcttattacc ctatcatagg cccaccccaa atggaagtcc     2520

cattcttcct caggatgttt aagattagca ttcaggaaga gatcagaggt ctgctggctc     2580

ccttatcatg tcccttatgg tgcttctggc tctgcaccgc gggaacagag aaacaggaga     2640

atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac     2700

agttggaaca gcagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg     2760

ctcagggcca agaacagatg gtccccagat gcggtcccgc cctcagcagt ttctagagaa     2820

ccatcagatg tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact     2880

aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctctatataa     2940

gcagagctcg tttagtgaac cgtcagatcg cggccgcgcc gccaccatgg tgagcaaggg     3000

cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg     3060

ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct     3120

gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct     3180

gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt     3240

caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg     3300

caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga     3360

gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa     3420

ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa     3480

cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca     3540

gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca     3600

gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt     3660

gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaagctt tatttgtgaa     3720

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     3780

aacaattgca ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc     3840

cctgcaggca atagccttga caaggcaaac ttgaccaata gtcttagagt atccagtgag     3900

gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctt cagcagttcc     3960

acacactcgc ttctggaacg tctgaggtta tcaataagct cctagtccag acgccatggg     4020

tcatttcaca gaggaggaca aggctactat cacaagcctg tggggcaagg tgaatgtgga     4080

agatgctgga ggagaaaccc tgggaaggta ggctctggtg accaggacaa gggagggaag     4140

gaaggaccct gtgcctggca aaagtccagg tcgcttctca ggatttgtgg caccttctga     4200

ctgtcaaact gttcttgtca atctcacagg ctcctggttg tctacccatg gacccagagg     4260

ttctttgaca gctttggcaa cctgtcctct gcctctgcca tcatgggcaa ccccaaagtc     4320

aaggcacatg gcaagaaggt gctgacttcc ttgggagatg ccacaaagca cctggatgat     4380

ctcaagggca cctttgccca gctgagtgaa ctgcactgtg acaagctgca tgtggatcct     4440

gagaacttca aggtgagtcc aggagatgtt tcagccctgt tgcctttagt ctcgaggcgt     4500

cgacaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4560

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4620

gagcgagcgc gcagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     4680

ttgcgcagcc tgaatggcga atggcgattc cgttgcaatg gctggcggta atattgttct     4740

ggatattacc agcaaggccg atagtttgag ttcttctact caggcaagtg atgttattac     4800

taatcaaaga agtattgcga caacggttaa tttgcgtgat ggacagactc ttttactcgg     4860

tggcctcact gattataaaa acacttctca ggattctggc gtaccgttcc tgtctaaaat     4920

ccctttaatc ggcctcctgt ttagctcccg ctctgattct aacgaggaaa gcacgttata     4980

cgtgctcgtc aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg     5040

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg     5100

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg     5160

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt     5220

agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt     5280

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta     5340

tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa     5400

atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt     5460

aaatatttgc ttatacaatc ttcctgtttt tggggctttt ctgattatca accggggtac     5520

atatgattga catgctagtt ttacgattac cgttcatcga ttctcttgtt tgctccagac     5580

tctcaggcaa tgacctgata gcctttgtag agacctctca aaaatagcta ccctctccgg     5640

catgaattta tcagctagaa cggttgaata tcatattgat ggtgatttga ctgtctccgg     5700

cctttctcac ccgtttgaat ctttacctac acattactca ggcattgcat ttaaaatata     5760

tgagggttct aaaaattttt atccttgcgt tgaaataaag gcttctcccg caaaagtatt     5820

acagggtcat aatgtttttg gtacaaccga tttagcttta tgctctgagg ctttattgct     5880

taattttgct aattctttgc cttgcctgta tgatttattg gatgttggaa tcgcctgatg     5940

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt     6000

acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac     6060

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     6120

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc     6180

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     6240

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     6300

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     6360

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     6420

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     6480

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     6540

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     6600

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     6660

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     6720

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     6780

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     6840

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     6900

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     6960

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     7020

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     7080

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     7140

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     7200

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     7260

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     7320

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     7380

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     7440

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     7500

tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag     7560

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     7620

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     7680

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     7740

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     7800

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     7860

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     7920

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     7980

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     8040

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt     8100

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag     8160

gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa     8220

tg                                                                    8222


<210>  15
<211>  8214
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  15
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgc ctacatacat acctgaataa gaaaaaaaaa      180

tacctttgct gagatgaaac acacatgatt tatttcaaat aggtacagag aagtagatac      240

tgaagtaagg attaagtatt atattatatt acataacatt aatctattcc tgcactgaaa      300

ccgttgcttt atatgatttt ttttttcact acactaatga gaacttaaga gataatggcc      360

taaaaccaca gagagtattt tcaaagataa gtatagcaca atgcttacta aatgagacta      420

agacttgtcc catcgaaaat cctggaccta tgcctaaaac acgtgtcaca atccccgaac      480

ttttcaaaaa ttggtacatg ctttaacttt aatctccagg cctcactgga gctagagaca      540

agaaggtaaa aaaaggctga caaaagaagt cctggtatct tctatggtgg gagaaggaaa      600

ctagctaaag ggaagaataa attagagaaa aattggaatg attgaatcgg aacaaggcaa      660

aggctataaa aaaattaagc agcagtatcc tcttgggggc cccttcccca cactatctca      720

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagtctt      780

gccttgacgc tagcgtaaat acacttgcaa aggaggatgt ttttagtagc aatttgtact      840

gatggtatgg ggccaagaga tatatcttag agggagggct gagggtttga agtccaactc      900

ctaagccagt gccagaagag ccaaggacag gtacggctgt catcacttag acctcaccct      960

gtggagccac accctagggt tggccaatct actcccagga gcagggaggg caggagccag     1020

ggctgggcat aaaagtcagg gcagagccat ctattgctta catttgcttc tgacacaact     1080

gtgttcacta gcaacctcaa acagacacca tggtgcacct gactcctgag gagaagtctg     1140

ccgttactgc cctgtggggc aaggtgaacg tggatgaagt tggtggtgag gccctgggca     1200

ggttggtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcatgtggag     1260

acagagaaga ctcttgggtt tctgataggc actgactctc tctgcctatt ggtctatttt     1320

cccaccctta ggctgctggt ggtctaccct tggacccaga ggttctttga gtcctttggg     1380

gatctgtcca ctcctgatgc tgttatgggc aaccctaagg tgaaggctca tggcaagaaa     1440

gtgctcggtg cctttagtga tggcctggct cacctggaca acctcaaggg cacctttgcc     1500

cagctgagtg agctgcactg tgacaagctg cacgtggatc ctgagaactt cagggtgagt     1560

ctatgggacc cttgatgttt tctttcccct tcttttctat ggttaagttc atgtcatagg     1620

aaggggagaa gtaacagggt acacatattg accaaatcag ggtaattttg catttgtaat     1680

tttaaaaaat gctttcttct tttaatatac ttttttgttt atcttatttc taatactttc     1740

cctaatctct ttctttcagg gcaataatga tacaatgtat catgcctctt tgcaccattc     1800

taaagaataa cagtgataat ttctgggtta aggcaatagc aatatttctg catataaata     1860

tttctgcata taaattgtaa ctgatgtaag aggtttcata ttgctaatag cagctacaat     1920

ccagctacca ttctgctttt attttatggt tgggataagg ctggattatt ctgagtccaa     1980

gctaggccct tttgctaatc atgttcatac ctcttatctt cctcccacag ctcctgggca     2040

acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga attcacccca ccagtgcagg     2100

ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct ggcccacaag tatcactaag     2160

ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact     2220

aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt     2280

attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa agggaatgtg     2340

ggaggttgca gtgctagtct cccggaacta tcactctttc acagtctgct ttggaaggac     2400

tgggcttagt atgaaaagtt aggactgaga agaatttgaa agggggcttt ttgtagcttg     2460

atattcacta ctgtcttatt accctatcat aggcccaccc caaatggaag tcccattctt     2520

cctcaggatg tttaagatta gcattcagga agagatcaga ggtctgctgg ctcccttatc     2580

atgtccctta tggtgcttct ggctctgcac cgcgggaaca gagaaacagg agaatatggg     2640

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga     2700

acagcagaat atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg     2760

ccaagaacag atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag     2820

atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat     2880

cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc     2940

tcgtttagtg aaccgtcaga tcgcggccgc gccgccacca tggtgagcaa gggcgaggag     3000

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     3060

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     3120

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac     3180

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     3240

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     3300

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     3360

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     3420

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     3480

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     3540

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc     3600

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     3660

gccgggatca ctctcggcat ggacgagctg tacaagtaag ctttatttgt gaaatttgtg     3720

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     3780

gcattcattt tatgtttcag gttcaggggg agatgtggga ggttttttaa agccctgcag     3840

gcaatagcct tgacaaggca accttgacca atagtcttag agtatcaggt gaggccaggg     3900

gccggcggct ggctagggat gaagaataaa aggaagcacc ctccagcagt tccacacact     3960

cgcttctgga acggctgaga ttatcaataa gctcctagtc cagacgccat gggtcatttc     4020

acagaggagg acaaggctac tatcacaagc ctgtggggca aggtgaatgt ggaagatgct     4080

ggaggagaaa ccctgggaag gtaggctctg gtgaccagga caaggaaggg aaggaaggac     4140

cctgtgcctg gcaaaagtcc aggccacttc tcaggatttg tggcactttc tgactgtcaa     4200

actgctcttg ttcaatctca caggctcctg gttgtctacc catggaccca gaggttcttt     4260

gacagctttg gcaacctgtc ctctgcctct gccatcatgg gcaaccccaa ggtcaaggca     4320

cacggcaaga aggtgctgac ttccttggga gatgccataa agaacctgga tgatctcaag     4380

ggcacctttg cccagctgag tgagctgcac tgtgacaagc tgcatgtgga tcctgagaac     4440

ttcagggtga gtccaggagt ttcagcagtt tcagagttca gtctcaaggc gtcgacagga     4500

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     4560

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     4620

gcgcagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag     4680

cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta     4740

ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa     4800

gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca     4860

ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa     4920

tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg     4980

tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     5040

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     5100

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     5160

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     5220

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     5280

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     5340

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     5400

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt     5460

gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt     5520

gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc     5580

aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt     5640

tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc     5700

acccgtttga atctttacct acacattact caggcattgc atttaaaata tatgagggtt     5760

ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc     5820

ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg     5880

ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt     5940

tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg     6000

ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg     6060

acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg     6120

catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat     6180

acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac     6240

ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat     6300

gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag     6360

tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc     6420

tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc     6480

acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc     6540

cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc     6600

ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt     6660

ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt     6720

atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat     6780

cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct     6840

tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat     6900

gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc     6960

ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg     7020

ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc     7080

tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta     7140

cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc     7200

ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga     7260

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     7320

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     7380

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     7440

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     7500

ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt     7560

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     7620

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     7680

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     7740

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     7800

gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     7860

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     7920

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     7980

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat     8040

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc     8100

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga     8160

agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg           8214


<210>  16
<211>  7712
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  16
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagtgcatc aacttcttat ttgtgtaata agaaaattgg gaaaacgatc ttcaatatgc      240

ttaccaagct gtgattccaa atattacgta aatacacttg caaaggagga tgtttttagt      300

agcaatttgt actgatggta tggggccaag agatatatct tagagggagg gctgagggtt      360

tgaagtccaa ctcctaagcc agtgccagaa gagccaagga caggtacggc tgtcatcact      420

tagacctcac cctgtggagc cacaccctag ggttggccaa tctactccca ggagcaggga      480

gggcaggagc cagggctggg cataaaagtc agggcagagc catctattgc ttacatttgc      540

ttctgacaca actgtgttca ctagcaacct caaacagaca ccaggtgagt taaacccatg      600

agagagaata acagaactgc gagtgatggg ccagttaagc gtagatggct aattagttca      660

gacaaatgta aaatgccaac accgtctgta aagaaaccta actgatcctc ttcctttgtc      720

ctgtcttctt cacaggccgc caccatggtc catcttacac cggaggagaa gtccgctgta      780

acggcactgt gggggaaagt taatgtcgat gaagtcggcg gtgaagcact cggcaggttg      840

ctggtagtgt acccgtggac acaacgattc tttgaaagtt tcggggacct gtccacaccc      900

gatgctgtga tgggtaatcc aaaagtaaaa gcacacggca agaaagtcct cggcgcgttt      960

agtgatggtc tggcccattt ggataacttg aagggtacat tcgcgcagct ttccgaactc     1020

cactgtgaca agttgcacgt agatccagaa aacttccggc ttctgggcaa tgtgcttgta     1080

tgcgttctgg ctcaccattt tgggaaggag tttaccccac ccgtgcaagc ggcttaccaa     1140

aaagtggtcg caggagtggc taatgccctt gcacataaat atcactaagg taccgataat     1200

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     1260

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     1320

gctttcattt tctcctcctt gtataaatcc tggttagttc ttgccacggc ggaactcatc     1380

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     1440

gtgtttattt gtgaaatttg tgatgctatt gctttatttg taaccattct agctttattt     1500

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta     1560

acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggagatgtgg gaggtttttt     1620

aaagcttaat taacgagatc gagaccatcc tggctaacac agtgaaaccc cgtctctact     1680

aaaaaaatac aaaaaattag ccgggcttgg tggcgggtgc ctgtagtccc agctactatg     1740

gaggctgagg cgggagaatg gcgtgaacgc ggggggcgga gcttgcagtg agcagagatc     1800

aggggccact gcactccagc ctgggcgaca gagagagact ctgtctcaaa aaaaagaaaa     1860

aaaaaattta gtagactagc taaaaaaatc cagagatagt tattgatgca tatgtaaaag     1920

tcttccaata tttacaagta caatgaaaaa aaaataacct tgaattaagt gtagaactca     1980

ttgacaatgt ttcaaaggat gtgagggata aactaaaatt tgggcagtac atgctgttcc     2040

tgtgtacttg gaacagaggg agaaaatctg ggctggaaat attgttatag gagttagcac     2100

atgaaggtga caactaaatt atttggagta gatggagtca ccagcacatg tgaatagttt     2160

tagaatgaaa tgacccaaga tagaactttg gagagccccc aaatttaaat aaaatcagta     2220

taagagaaga ggaagaaacc aaatggtata ctagtctaaa ttgtttctta gtgacaaaag     2280

aataacctga atattagatt agctgcctat atgctctctg aatcaatttc attcaacatg     2340

caacagtccg cgggaacaga gaaacaggag aatatgggcc aaacaggata tctgtggtaa     2400

gcagttcctg ccccggctca gggccaagaa cagttggaac agcagaatat gggccaaaca     2460

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga     2520

tgcggtcccg ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg     2580

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt     2640

cgcgcgcttc tgctccccga gctctatata agcagagctc gtttagtgaa ccgtcagatc     2700

gcctggagac gccatccacg ctgttttgac ttccatagaa ggcggccgcg ccgccaccat     2760

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2820

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2880

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2940

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     3000

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     3060

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     3120

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     3180

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     3240

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     3300

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     3360

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     3420

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagggaag     3480

cggagctact aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc     3540

tacctgcagg cctgagaact tcagggtgag tctatgggac gcttgatgtt ttctttcccc     3600

ttcttttcta tggttaagtt catgtcatag gaaggggata agtaacaggg tacagtttag     3660

aatgggaaac agacgaatga ttgcatcagt gtggaagtct caggatcgtt ttagtttctt     3720

ttatttgctg ttcataacaa ttgttttctt ttgtttaatt cttgctttct ttttttttct     3780

tctccgcaat ttttactatt atacttaatg ccttaacatt gtgtataaca aaaggaaata     3840

tctctgagat acattaagta acttaaaaaa aaactttaca cagtctgcct agtacattac     3900

tatttggaat atatgtgtgc ttatttgcat attcataatc tccctacttt gtcgacgtag     3960

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca     4020

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4080

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg ccagctggcg taatagcgaa     4140

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgattc     4200

cgttgcaatg gctggcggta atattgttct ggatattacc agcaaggccg atagtttgag     4260

ttcttctact caggcaagtg atgttattac taatcaaaga agtattgcga caacggttaa     4320

tttgcgtgat ggacagactc ttttactcgg tggcctcact gattataaaa acacttctca     4380

ggattctggc gtaccgttcc tgtctaaaat ccctttaatc ggcctcctgt ttagctcccg     4440

ctctgattct aacgaggaaa gcacgttata cgtgctcgtc aaagcaacca tagtacgcgc     4500

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     4560

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     4620

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     4680

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     4740

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     4800

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     4860

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     4920

attttaacaa aatattaacg tttacaattt aaatatttgc ttatacaatc ttcctgtttt     4980

tggggctttt ctgattatca accggggtac atatgattga catgctagtt ttacgattac     5040

cgttcatcga ttctcttgtt tgctccagac tctcaggcaa tgacctgata gcctttgtag     5100

agacctctca aaaatagcta ccctctccgg catgaattta tcagctagaa cggttgaata     5160

tcatattgat ggtgatttga ctgtctccgg cctttctcac ccgtttgaat ctttacctac     5220

acattactca ggcattgcat ttaaaatata tgagggttct aaaaattttt atccttgcgt     5280

tgaaataaag gcttctcccg caaaagtatt acagggtcat aatgtttttg gtacaaccga     5340

tttagcttta tgctctgagg ctttattgct taattttgct aattctttgc cttgcctgta     5400

tgatttattg gatgttggaa tcgcctgatg cggtattttc tccttacgca tctgtgcggt     5460

atttcacacc gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     5520

cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca     5580

tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg     5640

tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat     5700

gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga     5760

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     5820

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt     5880

gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg     5940

ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg     6000

gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg     6060

agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag     6120

caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca     6180

gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg     6240

agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc     6300

gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg     6360

aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg     6420

ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac     6480

tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg     6540

tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg     6600

gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact     6660

atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa     6720

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     6780

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     6840

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     6900

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     6960

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     7020

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     7080

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     7140

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     7200

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     7260

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     7320

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     7380

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     7440

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     7500

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     7560

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     7620

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg     7680

cctctccccg cgcgttggcc gattcattaa tg                                   7712


<210>  17
<211>  8293
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  17
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgt atacatacat acctgaatat ggaatcaaat      180

atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg      240

aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc      300

tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca      360

aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag      420

agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc      480

ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta      540

gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga      600

aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca      660

aggcaaaggc tataaaaaaa attaagcagc agtatcctct tgggggcccc ttccccacac      720

tatctcaatg caaatatctg tctgaaacgg tccctggcta aactccaccc atgggttggc      780

cagccttgcc ttgacgctag cgtaaataca cttgcaaagg aggatgtttt tagtagcaat      840

ttgtactgat ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt      900

ccaactccta agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc      960

tcaccctgtg gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag     1020

gagccagggc tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga     1080

cacaactgtg ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag     1140

aagtctgccg ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc     1200

ctgggcaggt tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca     1260

tgtggagaca gagaagactc ttgggtttct gataggcact gactctctct gcctattggt     1320

ctattttccc acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc     1380

ctttggggat ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg     1440

caagaaagtg ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac     1500

ctttgcccag ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag     1560

ggtgagtcta tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg     1620

tcataggaag gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat     1680

ttgtaatttt aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa     1740

tactttccct aatctctttc tttcagggca ataatgatac aatgtatcat gcctctttgc     1800

accattctaa agaataacag tgataatttc tgggttaagg caatagcaat atttctgcat     1860

ataaatattt ctgcatataa attgtaactg atgtaagagg tttcatattg ctaatagcag     1920

ctacaatcca gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg     1980

agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacagctc     2040

ctgggcaacg tgctggtctg tgtgctggcc catcactttg gcaaagaatt caccccacca     2100

gtgcaggctg cctatcagaa agtggtggct ggtgtggcta atgccctggc ccacaagtat     2160

cactaagctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc     2220

aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa     2280

aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt actaaaaagg     2340

gaatgtggga ggttgcagtg ctagtctccc ggaactatca ctctttcaca gtctgctttg     2400

gaaggactgg gcttagtatg aaaagttagg actgagaaga atttgaaagg gggctttttg     2460

tagcttgata ttcactactg tcttattacc ctatcatagg cccaccccaa atggaagtcc     2520

cattcttcct caggatgttt aagattagca ttcaggaaga gatcagaggt ctgctggctc     2580

ccttatcatg tcccttatgg tgcttctggc tctgcaccgc ggccacgggg ttggggttgc     2640

gccttttcca aggcagccct gggtttgcgc agggacgcgg ctgctctggg cgtggttccg     2700

ggaaacgcag cggcgccgac cctgggtctc gcacattctt cacgtccgtt cgcagcgtca     2760

cccggatctt cgccgctacc cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa     2820

gtcgggaagg ttccttgcgg ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc     2880

tcactagtac cctcgcagac ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat     2940

gggctgtggc caatagcggc tgctcagcgg ggcgcgccga gagcagcggc cgggaagggg     3000

cggtgcggga ggcggggtgt ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt     3060

ccgcattctg caagcctccg gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca     3120

ccgacctctc tccccagcgg ccgcgccgcc accatggaca aggattgtga aatgaaacgc     3180

accacactgg acagcccttt ggggaagctg gagctgtctg gttgtgagca gggtctgcac     3240

gaaataaagc tcctgggcaa ggggacgtct gcagctgatg ccgtggaggt cccagccccc     3300

gctgcggttc tcggaggtcc ggagcccctg atgcagtgca cagcctggct gaatgcctat     3360

ttccaccagc ccgaggctat cgaagagttc cccgtgccgg ctcttcacca tcccgttttc     3420

cagcaagagt cgttcaccag acaggtgtta tggaagctgc tgaaggttgt gaaattcgga     3480

gaagtgattt cttaccagca attagcagcc ctggcaggca accccaaagc cgcgcgagca     3540

gtgggaggag caatgagagg caatcctgtc aaaatcctca tcccgtgcca cagagtggtc     3600

tgcagcagcg gagccgtggg caactactcc ggaggactgg ccgtgaagga atggcttctg     3660

gcccatgaag gccaccggtt ggggaagcca ggcttgggag ggagctcagg tctggcaggg     3720

gcctggctca agggagcggg agctacctcg ggctccccgc ctgctggccg aaactaagct     3780

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     3840

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg     3900

ttttttaaag ccctgcaggc aatagccttg acaaggcaaa cttgaccaat agtcttagag     3960

tatccagtga ggccaggggc cggcggctgg ctagggatga agaataaaag gaagcaccct     4020

tcagcagttc cacacactcg cttctggaac gtctgaggtt atcaataagc tcctagtcca     4080

gacgccatgg gtcatttcac agaggaggac aaggctacta tcacaagcct gtggggcaag     4140

gtgaatgtgg aagatgctgg aggagaaacc ctgggaaggt aggctctggt gaccaggaca     4200

agggagggaa ggaaggaccc tgtgcctggc aaaagtccag gtcgcttctc aggatttgtg     4260

gcaccttctg actgtcaaac tgttcttgtc aatctcacag gctcctggtt gtctacccat     4320

ggacccagag gttctttgac agctttggca acctgtcctc tgcctctgcc atcatgggca     4380

accccaaagt caaggcacat ggcaagaagg tgctgacttc cttgggagat gccacaaagc     4440

acctggatga tctcaagggc acctttgccc agctgagtga actgcactgt gacaagctgc     4500

atgtggatcc tgagaacttc aaggtgagtc caggagatgt ttcagccctg ttgcctttag     4560

tctcgaggcg tcgacaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     4620

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     4680

cctcagtgag cgagcgagcg cgcagctggc gtaatagcga agaggcccgc accgatcgcc     4740

cttcccaaca gttgcgcagc ctgaatggcg aatggcgatt ccgttgcaat ggctggcggt     4800

aatattgttc tggatattac cagcaaggcc gatagtttga gttcttctac tcaggcaagt     4860

gatgttatta ctaatcaaag aagtattgcg acaacggtta atttgcgtga tggacagact     4920

cttttactcg gtggcctcac tgattataaa aacacttctc aggattctgg cgtaccgttc     4980

ctgtctaaaa tccctttaat cggcctcctg tttagctccc gctctgattc taacgaggaa     5040

agcacgttat acgtgctcgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag     5100

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     5160

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     5220

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     5280

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     5340

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     5400

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     5460

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac     5520

gtttacaatt taaatatttg cttatacaat cttcctgttt ttggggcttt tctgattatc     5580

aaccggggta catatgattg acatgctagt tttacgatta ccgttcatcg attctcttgt     5640

ttgctccaga ctctcaggca atgacctgat agcctttgta gagacctctc aaaaatagct     5700

accctctccg gcatgaattt atcagctaga acggttgaat atcatattga tggtgatttg     5760

actgtctccg gcctttctca cccgtttgaa tctttaccta cacattactc aggcattgca     5820

tttaaaatat atgagggttc taaaaatttt tatccttgcg ttgaaataaa ggcttctccc     5880

gcaaaagtat tacagggtca taatgttttt ggtacaaccg atttagcttt atgctctgag     5940

gctttattgc ttaattttgc taattctttg ccttgcctgt atgatttatt ggatgttgga     6000

atcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt     6060

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     6120

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     6180

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     6240

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     6300

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     6360

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     6420

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     6480

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     6540

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     6600

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     6660

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     6720

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     6780

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     6840

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     6900

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     6960

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     7020

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     7080

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     7140

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     7200

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     7260

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     7320

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     7380

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     7440

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     7500

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     7560

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     7620

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     7680

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     7740

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     7800

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     7860

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     7920

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     7980

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     8040

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     8100

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     8160

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     8220

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     8280

cgattcatta atg                                                        8293


<210>  18
<211>  8126
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  18
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgt atacatacat acctgaatat ggaatcaaat      180

atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg      240

aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc      300

tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca      360

aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag      420

agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc      480

ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta      540

gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga      600

aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca      660

aggcaaaggc tataaaaaaa attaagcagc agtatcctct tgggggcccc ttccccacac      720

tatctcaatg caaatatctg tctgaaacgg tccctggcta aactccaccc atgggttggc      780

cagccttgcc ttgacaaggc aaacttgacc aatagtctta gagtatccag tgaggccagg      840

ggccggcggc tggctaggga tgaagaataa aaggaagcac ccttcagcag ttccacacac      900

tcgcttctgg aacgtctgag gttatcaata agctcctagt ccagacgcca tggtgcacct      960

gactcctgag gagaagtctg ccgttactgc cctgtggggc aaggtgaacg tggatgaagt     1020

tggtggtgag gccctgggca ggttggtatc aaggttacaa gacaggttta aggagaccaa     1080

tagaaactgg gcatgtggag acagagaaga ctcttgggtt tctgataggc actgactctc     1140

tctgcctatt ggtctatttt cccaccctta ggctgctggt ggtctaccct tggacccaga     1200

ggttctttga gtcctttggg gatctgtcca ctcctgatgc tgttatgggc aaccctaagg     1260

tgaaggctca tggcaagaaa gtgctcggtg cctttagtga tggcctggct cacctggaca     1320

acctcaaggg cacctttgcc cagctgagtg agctgcactg tgacaagctg cacgtggatc     1380

ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct tcttttctat     1440

ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg accaaatcag     1500

ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac ttttttgttt     1560

atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga tacaatgtat     1620

catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta aggcaatagc     1680

aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag aggtttcata     1740

ttgctaatag cagctacaat ccagctacca ttctgctttt attttatggt tgggataagg     1800

ctggattatt ctgagtccaa gctaggccct tttgctaatc atgttcatac ctcttatctt     1860

cctcccacag ctcctgggca acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga     1920

attcacccca ccagtgcagg ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct     1980

ggcccacaag tatcactaag ctcgctttct tgctgtccaa tttctattaa aggttccttt     2040

gttccctaag tccaactact aaactggggg atattatgaa gggccttgag catctggatt     2100

ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat     2160

tttactaaaa agggaatgtg ggaggttgca gtgctagtct cccggaacta tcactctttc     2220

acagtctgct ttggaaggac tgggcttagt atgaaaagtt aggactgaga agaatttgaa     2280

agggggcttt ttgtagcttg atattcacta ctgtcttatt accctatcat aggcccaccc     2340

caaatggaag tcccattctt cctcaggatg tttaagatta gcattcagga agagatcaga     2400

ggtctgctgg ctcccttatc atgtccctta tggtgcttct ggctctgcac cgcggccacg     2460

gggttggggt tgcgcctttt ccaaggcagc cctgggtttg cgcagggacg cggctgctct     2520

gggcgtggtt ccgggaaacg cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc     2580

gttcgcagcg tcacccggat cttcgccgct acccttgtgg gccccccggc gacgcttcct     2640

gctccgcccc taagtcggga aggttccttg cggttcgcgg cgtgccggac gtgacaaacg     2700

gaagccgcac gtctcactag taccctcgca gacggacagc gccagggagc aatggcagcg     2760

cgccgaccgc gatgggctgt ggccaatagc ggctgctcag cggggcgcgc cgagagcagc     2820

ggccgggaag gggcggtgcg ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg     2880

cccgcgcggt gttccgcatt ctgcaagcct ccggagcgca cgtcggcagt cggctccctc     2940

gttgaccgaa tcaccgacct ctctccccag cggccgcgcc gccaccatgg acaaggattg     3000

tgaaatgaaa cgcaccacac tggacagccc tttggggaag ctggagctgt ctggttgtga     3060

gcagggtctg cacgaaataa agctcctggg caaggggacg tctgcagctg atgccgtgga     3120

ggtcccagcc cccgctgcgg ttctcggagg tccggagccc ctgatgcagt gcacagcctg     3180

gctgaatgcc tatttccacc agcccgaggc tatcgaagag ttccccgtgc cggctcttca     3240

ccatcccgtt ttccagcaag agtcgttcac cagacaggtg ttatggaagc tgctgaaggt     3300

tgtgaaattc ggagaagtga tttcttacca gcaattagca gccctggcag gcaaccccaa     3360

agccgcgcga gcagtgggag gagcaatgag aggcaatcct gtcaaaatcc tcatcccgtg     3420

ccacagagtg gtctgcagca gcggagccgt gggcaactac tccggaggac tggccgtgaa     3480

ggaatggctt ctggcccatg aaggccaccg gttggggaag ccaggcttgg gagggagctc     3540

aggtctggca ggggcctggc tcaagggagc gggagctacc tcgggctccc cgcctgctgg     3600

ccgaaactaa gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     3660

agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg     3720

gagatgtggg aggtttttta aagccctgca ggcaatagcc ttgacaaggc aaacttgacc     3780

aatagtctta gagtatccag tgaggccagg ggccggcggc tggctaggga tgaagaataa     3840

aaggaagcac ccttcagcag ttccacacac tcgcttctgg aacgtctgag gttatcaata     3900

agctcctagt ccagacgcca tgggtcattt cacagaggag gacaaggcta ctatcacaag     3960

cctgtggggc aaggtgaatg tggaagatgc tggaggagaa accctgggaa ggtaggctct     4020

ggtgaccagg acaagggagg gaaggaagga ccctgtgcct ggcaaaagtc caggtcgctt     4080

ctcaggattt gtggcacctt ctgactgtca aactgttctt gtcaatctca caggctcctg     4140

gttgtctacc catggaccca gaggttcttt gacagctttg gcaacctgtc ctctgcctct     4200

gccatcatgg gcaaccccaa agtcaaggca catggcaaga aggtgctgac ttccttggga     4260

gatgccacaa agcacctgga tgatctcaag ggcacctttg cccagctgag tgaactgcac     4320

tgtgacaagc tgcatgtgga tcctgagaac ttcaaggtga gtccaggaga tgtttcagcc     4380

ctgttgcctt tagtctcgag gcgtcgacag gaacccctag tgatggagtt ggccactccc     4440

tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc     4500

tttgcccggg cggcctcagt gagcgagcga gcgcgcagct ggcgtaatag cgaagaggcc     4560

cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggcg attccgttgc     4620

aatggctggc ggtaatattg ttctggatat taccagcaag gccgatagtt tgagttcttc     4680

tactcaggca agtgatgtta ttactaatca aagaagtatt gcgacaacgg ttaatttgcg     4740

tgatggacag actcttttac tcggtggcct cactgattat aaaaacactt ctcaggattc     4800

tggcgtaccg ttcctgtcta aaatcccttt aatcggcctc ctgtttagct cccgctctga     4860

ttctaacgag gaaagcacgt tatacgtgct cgtcaaagca accatagtac gcgccctgta     4920

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     4980

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     5040

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     5100

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     5160

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     5220

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     5280

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     5340

acaaaatatt aacgtttaca atttaaatat ttgcttatac aatcttcctg tttttggggc     5400

ttttctgatt atcaaccggg gtacatatga ttgacatgct agttttacga ttaccgttca     5460

tcgattctct tgtttgctcc agactctcag gcaatgacct gatagccttt gtagagacct     5520

ctcaaaaata gctaccctct ccggcatgaa tttatcagct agaacggttg aatatcatat     5580

tgatggtgat ttgactgtct ccggcctttc tcacccgttt gaatctttac ctacacatta     5640

ctcaggcatt gcatttaaaa tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat     5700

aaaggcttct cccgcaaaag tattacaggg tcataatgtt tttggtacaa ccgatttagc     5760

tttatgctct gaggctttat tgcttaattt tgctaattct ttgccttgcc tgtatgattt     5820

attggatgtt ggaatcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca     5880

caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc     5940

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     6000

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     6060

ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     6120

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     6180

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     6240

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     6300

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     6360

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     6420

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     6480

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     6540

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     6600

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     6660

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     6720

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     6780

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc     6840

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     6900

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     6960

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     7020

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     7080

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     7140

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     7200

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     7260

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     7320

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     7380

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     7440

ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     7500

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     7560

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     7620

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     7680

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     7740

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     7800

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     7860

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     7920

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     7980

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     8040

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     8100

cccgcgcgtt ggccgattca ttaatg                                          8126


<210>  19
<211>  8024
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  19
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg aggtaagcat      240

taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc tttatagaaa      300

ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca aagagtatat      360

tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag agactaagat      420

ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc ctgaactttt      480

caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta gagacaagaa      540

ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga aggaaactag      600

ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca aggcaaaggc      660

tataaaaaaa attagcagta tcctcttggg ggccccttcc ccacactatc tcaatgcaaa      720

tatctgtctg aaacggtccc tggctaaact ccacccatgg gttggccagc cttgccttga      780

caaggcaaac ttgaccaata gtcttagagt atccagtgag gccaggggcc ggcggctggc      840

tagggatgaa gaataaaagg aagcaccctt cagcagttcc acacactcgc ttctggaacg      900

tctgaggtta tcaataagct cctagtccag acgccatggt gcacctgact cctgaggaga      960

agtctgccgt tactgccctg tggggcaagg tgaacgtgga tgaagttggt ggtgaggccc     1020

tgggcaggtt ggtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggcat     1080

gtggagacag agaagactct tgggtttctg ataggcactg actctctctg cctattggtc     1140

tattttccca cccttaggct gctggtggtc tacccttgga cccagaggtt ctttgagtcc     1200

tttggggatc tgtccactcc tgatgctgtt atgggcaacc ctaaggtgaa ggctcatggc     1260

aagaaagtgc tcggtgcctt tagtgatggc ctggctcacc tggacaacct caagggcacc     1320

tttgcccagc tgagtgagct gcactgtgac aagctgcacg tggatcctga gaacttcagg     1380

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt     1440

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt     1500

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat     1560

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca     1620

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata     1680

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc     1740

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga     1800

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagctcc     1860

tgggcaacgt gctggtctgt gtgctggccc atcactttgg caaagaattc accccaccag     1920

tgcaggctgc ctatcagaaa gtggtggctg gtgtggctaa tgccctggcc cacaagtatc     1980

actaagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca     2040

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa     2100

acatttattt tcattgcaat gatgtattta aattatttct gaatatttta ctaaaaaggg     2160

aatgtgggag gttgcagtgc tagtctcccg gaactatcac tctttcacag tctgctttgg     2220

aaggactggg cttagtatga aaagttagga ctgagaagaa tttgaaaggg ggctttttgt     2280

agcttgatat tcactactgt cttattaccc tatcataggc ccaccccaaa tggaagtccc     2340

attcttcctc aggatgttta agattagcat tcaggaagag atcagaggtc tgctggctcc     2400

cttatcatgt cccttatggt gcttctggct ctgcaccgcg gccacggggt tggggttgcg     2460

ccttttccaa ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg     2520

gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac     2580

ccggatcttc gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag     2640

tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct     2700

cactagtacc ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg     2760

ggctgtggcc aatagcggct gctcagcggg gcgcgccgag agcagcggcc gggaaggggc     2820

ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc     2880

cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac     2940

cgacctctct ccccagcggc cgcgccgcca ccatggacaa ggattgtgaa atgaaacgca     3000

ccacactgga cagccctttg gggaagctgg agctgtctgg ttgtgagcag ggtctgcacg     3060

aaataaagct cctgggcaag gggacgtctg cagctgatgc cgtggaggtc ccagcccccg     3120

ctgcggttct cggaggtccg gagcccctga tgcagtgcac agcctggctg aatgcctatt     3180

tccaccagcc cgaggctatc gaagagttcc ccgtgccggc tcttcaccat cccgttttcc     3240

agcaagagtc gttcaccaga caggtgttat ggaagctgct gaaggttgtg aaattcggag     3300

aagtgatttc ttaccagcaa ttagcagccc tggcaggcaa ccccaaagcc gcgcgagcag     3360

tgggaggagc aatgagaggc aatcctgtca aaatcctcat cccgtgccac agagtggtct     3420

gcagcagcgg agccgtgggc aactactccg gaggactggc cgtgaaggaa tggcttctgg     3480

cccatgaagg ccaccggttg gggaagccag gcttgggagg gagctcaggt ctggcagggg     3540

cctggctcaa gggagcggga gctacctcgg gctccccgcc tgctggccga aacgagggca     3600

gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc gggcccccct gcaggaactt     3660

caaggtgagt ccaggagatg tttcagccct gttgccttta gtctcgaggc aacttagaca     3720

acggagtatt gatctgagca cagcagggtg tgagctgttt gaagatactg gggttggggg     3780

tgaagaaact gcagaggact aactgggctg agacccagtg gtaatgtttt agggcctaag     3840

gagtgcctct aaaaatctag atggacaatt ttgactttga gaaaagagag gtggaaatga     3900

ggaaaatgac ttttctttat tagattccag tagaaagaac tttcatcttt ccctcatttt     3960

tgttgtttta aaacatctat ctggaggcag gacaagtatg gtcgttaaaa agatgcaggc     4020

agaaggcata tattggctca gtcaaagtgg ggaactttgg tggccaaaca tacattgcta     4080

aggctattcc tatatcagct ggacacatat aaaatgctgc taatgcttca ttacaaactt     4140

atatccttta attccagatg ggggcaaagt atgtccaggg gtgaggaaca attgaaacat     4200

ttgggctgga gtagattttg aaagtcagct ctgtgtgtgt gtgtgtgtgt gcgcgcgcgc     4260

gtgtcgacgt agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga     4320

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     4380

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgccagctgg     4440

cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc     4500

gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta ccagcaaggc     4560

cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa gaagtattgc     4620

gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca ctgattataa     4680

aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa tcggcctcct     4740

gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg tcaaagcaac     4800

catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     4860

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     4920

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     4980

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     5040

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     5100

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     5160

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     5220

aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt gcttatacaa     5280

tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt gacatgctag     5340

ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc aatgacctga     5400

tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt tatcagctag     5460

aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc acccgtttga     5520

atctttacct acacattact caggcattgc atttaaaata tatgagggtt ctaaaaattt     5580

ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc ataatgtttt     5640

tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg ctaattcttt     5700

gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt tctccttacg     5760

catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg ctctgatgcc     5820

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     5880

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     5940

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     6000

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     6060

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     6120

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     6180

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     6240

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     6300

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     6360

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     6420

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     6480

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     6540

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     6600

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     6660

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     6720

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     6780

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     6840

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     6900

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     6960

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     7020

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     7080

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     7140

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     7200

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     7260

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     7320

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     7380

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     7440

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7500

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7560

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     7620

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     7680

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     7740

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     7800

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     7860

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     7920

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca     7980

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg                      8024


<210>  20
<211>  7729
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  20
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccgcgggaa cagagaaaca      660

ggagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca      720

agaacagttg gaacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc      780

cccggctcag ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta      840

gagaaccatc agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt      900

gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcta      960

tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt     1020

tgacttccat agaaggcggc cgcgccgcca ccatggacaa ggattgtgaa atgaaacgca     1080

ccacactgga cagccctttg gggaagctgg agctgtctgg ttgtgagcag ggtctgcacg     1140

aaataaagct cctgggcaag gggacgtctg cagctgatgc cgtggaggtc ccagcccccg     1200

ctgcggttct cggaggtccg gagcccctga tgcagtgcac agcctggctg aatgcctatt     1260

tccaccagcc cgaggctatc gaagagttcc ccgtgccggc tcttcaccat cccgttttcc     1320

agcaagagtc gttcaccaga caggtgttat ggaagctgct gaaggttgtg aaattcggag     1380

aagtgatttc ttaccagcaa ttagcagccc tggcaggcaa ccccaaagcc gcgcgagcag     1440

tgggaggagc aatgagaggc aatcctgtca aaatcctcat cccgtgccac agagtggtct     1500

gcagcagcgg agccgtgggc aactactccg gaggactggc cgtgaaggaa tggcttctgg     1560

cccatgaagg ccaccggttg gggaagccag gcttgggagg gagctcaggt ctggcagggg     1620

cctggctcaa gggagcggga gctacctcgg gctccccgcc tgctggccga aactaacctg     1680

cagggataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     1740

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     1800

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttagttc ttgccacggc     1860

ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga     1920

caattccgtg gtgtttattt gtgaaatttg tgatgctatt gctttatttg taaccattct     1980

agctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     2040

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggagatgtgg     2100

gaggtttttt aaagcgaatt ccgagatcga gaccatcctg gctaacacag tgaaaccccg     2160

tctctactaa aaaaatacaa aaaattagcc gggcttggtg gcgggtgcct gtagtcccag     2220

ctactatgga ggctgaggcg ggagaatggc gtgaacgcgg ggggcggagc ttgcagtgag     2280

cagagatcag gggccactgc actccagcct gggcgacaga gagagactct gtctcaaaaa     2340

aaagaaaaaa aaaatttagt agactagcta aaaaaatcca gagatagtta ttgatgcata     2400

tgtaaaagtc ttccaatatt tacaagtaca atgaaaaaaa aataaccttg aattaagtgt     2460

agaactcatt gacaatgttt caaaggatgt gagggataaa ctaaaatttg ggcagtacat     2520

gctgttcctg tgtacttgga acagagggag aaaatctggg ctggaaatat tgttatagga     2580

gttagcacat gaaggtgaca actaaattat ttggagtaga tggagtcacc agcacatgtg     2640

aatagtttta gaatgaaatg acccaagata gaactttgga gagcccccaa atttaaataa     2700

aatcagtata agagaagagg aagaaaccaa atggtatact agtctaaatt gtttcttagt     2760

gacaaaagaa taacctgaat attagattag ctgcctatat gctctctgaa tcaatttcat     2820

tcaacatgca acagttctgg aacctatcag ggaccacagt cagccaggca agcacatctg     2880

cccaagccaa gggtggaggc atgcagctgt gggggtctgt gaaaacactt gagggagcag     2940

ataactgggc caaccatgac tcagtgcttc tggaggccaa caggactgct gagtcatcct     3000

gtgggggtgg aggtgggaca agggaaaggg gtgaatggta ctgctgatta caacctctgg     3060

tgctgcctcc ccctcctgtt tatctgagag gctagcgtaa atacacttgc aaaggaggat     3120

gtttttagta gcaatttgta ctgatggtat ggggccaaga gatatatctt agagggaggg     3180

ctgagggttt gaagtccaac tcctaagcca gtgccagaag agccaaggac aggtacggct     3240

gtcatcactt agacctcacc ctgtggagcc acaccctagg gttggccaat ctactcccag     3300

gagcagggag ggcaggagcc agggctgggc ataaaagtca gggcagagcc atctattgct     3360

tacactcgct tctggaacgt ctgaggttat caataagctc ctagtccaga cgccatgggt     3420

catttcacag aggaggacaa ggctactatc acaagcctgt ggggcaaggt gaatgtggaa     3480

gatgctggag gagaaaccct gggaaggtag gctctggtga ccaggacaag ggagggaagg     3540

aaggaccctg tgcctggcaa aagtccaggt cgcttctcag gatttgtggc accttctgac     3600

tgtcaaactg ttcttgtcaa tctcacaggc tcctggttgt ctacccatgg acccagaggt     3660

tctttgacag ctttggcaac ctgtcctctg cctctgccat catgggcaac cccaaagtca     3720

aggcacatgg caagaaggtg ctgacttcct tgggagatgc cacaaagcac ctggatgatc     3780

tcaagggcac ctttgcccag ctgagtgaac tgcactgtga caagctgcat gtggatcctg     3840

agaacttcaa ggtgagtcca ggagatgttt cagccctgtt gcctttagtc tcgaggcaac     3900

ttagacaacg gagtattgat ctgagcacag cagggtgtga gctgtttgaa gatactgggg     3960

tctcgaggtc gacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct     4020

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4080

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca     4140

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     4200

atggcgaatg gcgattccgt tgcaatggct ggcggtaata ttgttctgga tattaccagc     4260

aaggccgata gtttgagttc ttctactcag gcaagtgatg ttattactaa tcaaagaagt     4320

attgcgacaa cggttaattt gcgtgatgga cagactcttt tactcggtgg cctcactgat     4380

tataaaaaca cttctcagga ttctggcgta ccgttcctgt ctaaaatccc tttaatcggc     4440

ctcctgttta gctcccgctc tgattctaac gaggaaagca cgttatacgt gctcgtcaaa     4500

gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4560

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4620

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4680

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     4740

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     4800

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     4860

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     4920

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttaaa tatttgctta     4980

tacaatcttc ctgtttttgg ggcttttctg attatcaacc ggggtacata tgattgacat     5040

gctagtttta cgattaccgt tcatcgattc tcttgtttgc tccagactct caggcaatga     5100

cctgatagcc tttgtagaga cctctcaaaa atagctaccc tctccggcat gaatttatca     5160

gctagaacgg ttgaatatca tattgatggt gatttgactg tctccggcct ttctcacccg     5220

tttgaatctt tacctacaca ttactcaggc attgcattta aaatatatga gggttctaaa     5280

aatttttatc cttgcgttga aataaaggct tctcccgcaa aagtattaca gggtcataat     5340

gtttttggta caaccgattt agctttatgc tctgaggctt tattgcttaa ttttgctaat     5400

tctttgcctt gcctgtatga tttattggat gttggaatcg cctgatgcgg tattttctcc     5460

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg     5520

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     5580

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     5640

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     5700

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     5760

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     5820

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     5880

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     5940

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6000

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6060

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6120

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6180

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     6240

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     6300

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6360

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6420

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6480

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6540

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6600

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6660

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     6720

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6780

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     6840

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     6900

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     6960

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7020

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7080

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7140

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7200

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7260

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7320

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7380

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7440

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7500

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7560

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7620

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     7680

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatg                 7729


<210>  21
<211>  8285
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  21
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgc ctacatacat acctgaataa gaaaaaaaaa      180

tacctttgct gagatgaaac acacatgatt tatttcaaat aggtacagag aagtagatac      240

tgaagtaagg attaagtatt atattatatt acataacatt aatctattcc tgcactgaaa      300

ccgttgcttt atatgatttt ttttttcact acactaatga gaacttaaga gataatggcc      360

taaaaccaca gagagtattt tcaaagataa gtatagcaca atgcttacta aatgagacta      420

agacttgtcc catcgaaaat cctggaccta tgcctaaaac acgtgtcaca atccccgaac      480

ttttcaaaaa ttggtacatg ctttaacttt aatctccagg cctcactgga gctagagaca      540

agaaggtaaa aaaaggctga caaaagaagt cctggtatct tctatggtgg gagaaggaaa      600

ctagctaaag ggaagaataa attagagaaa aattggaatg attgaatcgg aacaaggcaa      660

aggctataaa aaaattaagc agcagtatcc tcttgggggc cccttcccca cactatctca      720

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagtctt      780

gccttgacgc tagcgtaaat acacttgcaa aggaggatgt ttttagtagc aatttgtact      840

gatggtatgg ggccaagaga tatatcttag agggagggct gagggtttga agtccaactc      900

ctaagccagt gccagaagag ccaaggacag gtacggctgt catcacttag acctcaccct      960

gtggagccac accctagggt tggccaatct actcccagga gcagggaggg caggagccag     1020

ggctgggcat aaaagtcagg gcagagccat ctattgctta catttgcttc tgacacaact     1080

gtgttcacta gcaacctcaa acagacacca tggtgcacct gactcctgag gagaagtctg     1140

ccgttactgc cctgtggggc aaggtgaacg tggatgaagt tggtggtgag gccctgggca     1200

ggttggtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcatgtggag     1260

acagagaaga ctcttgggtt tctgataggc actgactctc tctgcctatt ggtctatttt     1320

cccaccctta ggctgctggt ggtctaccct tggacccaga ggttctttga gtcctttggg     1380

gatctgtcca ctcctgatgc tgttatgggc aaccctaagg tgaaggctca tggcaagaaa     1440

gtgctcggtg cctttagtga tggcctggct cacctggaca acctcaaggg cacctttgcc     1500

cagctgagtg agctgcactg tgacaagctg cacgtggatc ctgagaactt cagggtgagt     1560

ctatgggacc cttgatgttt tctttcccct tcttttctat ggttaagttc atgtcatagg     1620

aaggggagaa gtaacagggt acacatattg accaaatcag ggtaattttg catttgtaat     1680

tttaaaaaat gctttcttct tttaatatac ttttttgttt atcttatttc taatactttc     1740

cctaatctct ttctttcagg gcaataatga tacaatgtat catgcctctt tgcaccattc     1800

taaagaataa cagtgataat ttctgggtta aggcaatagc aatatttctg catataaata     1860

tttctgcata taaattgtaa ctgatgtaag aggtttcata ttgctaatag cagctacaat     1920

ccagctacca ttctgctttt attttatggt tgggataagg ctggattatt ctgagtccaa     1980

gctaggccct tttgctaatc atgttcatac ctcttatctt cctcccacag ctcctgggca     2040

acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga attcacccca ccagtgcagg     2100

ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct ggcccacaag tatcactaag     2160

ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact     2220

aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt     2280

attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa agggaatgtg     2340

ggaggttgca gtgctagtct cccggaacta tcactctttc acagtctgct ttggaaggac     2400

tgggcttagt atgaaaagtt aggactgaga agaatttgaa agggggcttt ttgtagcttg     2460

atattcacta ctgtcttatt accctatcat aggcccaccc caaatggaag tcccattctt     2520

cctcaggatg tttaagatta gcattcagga agagatcaga ggtctgctgg ctcccttatc     2580

atgtccctta tggtgcttct ggctctgcac cgcggccacg gggttggggt tgcgcctttt     2640

ccaaggcagc cctgggtttg cgcagggacg cggctgctct gggcgtggtt ccgggaaacg     2700

cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg tcacccggat     2760

cttcgccgct acccttgtgg gccccccggc gacgcttcct gctccgcccc taagtcggga     2820

aggttccttg cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac gtctcactag     2880

taccctcgca gacggacagc gccagggagc aatggcagcg cgccgaccgc gatgggctgt     2940

ggccaatagc ggctgctcag cggggcgcgc cgagagcagc ggccgggaag gggcggtgcg     3000

ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt gttccgcatt     3060

ctgcaagcct ccggagcgca cgtcggcagt cggctccctc gttgaccgaa tcaccgacct     3120

ctctccccag cggccgcgcc gccaccatgg acaaggattg tgaaatgaaa cgcaccacac     3180

tggacagccc tttggggaag ctggagctgt ctggttgtga gcagggtctg cacgaaataa     3240

agctcctggg caaggggacg tctgcagctg atgccgtgga ggtcccagcc cccgctgcgg     3300

ttctcggagg tccggagccc ctgatgcagt gcacagcctg gctgaatgcc tatttccacc     3360

agcccgaggc tatcgaagag ttccccgtgc cggctcttca ccatcccgtt ttccagcaag     3420

agtcgttcac cagacaggtg ttatggaagc tgctgaaggt tgtgaaattc ggagaagtga     3480

tttcttacca gcaattagca gccctggcag gcaaccccaa agccgcgcga gcagtgggag     3540

gagcaatgag aggcaatcct gtcaaaatcc tcatcccgtg ccacagagtg gtctgcagca     3600

gcggagccgt gggcaactac tccggaggac tggccgtgaa ggaatggctt ctggcccatg     3660

aaggccaccg gttggggaag ccaggcttgg gagggagctc aggtctggca ggggcctggc     3720

tcaagggagc gggagctacc tcgggctccc cgcctgctgg ccgaaactaa gctttatttg     3780

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     3840

caacaacaat tgcattcatt ttatgtttca ggttcagggg gagatgtggg aggtttttta     3900

aagccctgca ggcaatagcc ttgacaaggc aaccttgacc aatagtctta gagtatcagg     3960

tgaggccagg ggccggcggc tggctaggga tgaagaataa aaggaagcac cctccagcag     4020

ttccacacac tcgcttctgg aacggctgag attatcaata agctcctagt ccagacgcca     4080

tgggtcattt cacagaggag gacaaggcta ctatcacaag cctgtggggc aaggtgaatg     4140

tggaagatgc tggaggagaa accctgggaa ggtaggctct ggtgaccagg acaaggaagg     4200

gaaggaagga ccctgtgcct ggcaaaagtc caggccactt ctcaggattt gtggcacttt     4260

ctgactgtca aactgctctt gttcaatctc acaggctcct ggttgtctac ccatggaccc     4320

agaggttctt tgacagcttt ggcaacctgt cctctgcctc tgccatcatg ggcaacccca     4380

aggtcaaggc acacggcaag aaggtgctga cttccttggg agatgccata aagaacctgg     4440

atgatctcaa gggcaccttt gcccagctga gtgagctgca ctgtgacaag ctgcatgtgg     4500

atcctgagaa cttcagggtg agtccaggag tttcagcagt ttcagagttc agtctcaagg     4560

cgtcgacagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     4620

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     4680

agcgagcgag cgcgcagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa     4740

cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt     4800

tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat     4860

tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact     4920

cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa     4980

aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt     5040

atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg     5100

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     5160

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     5220

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     5280

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     5340

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     5400

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     5460

aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa     5520

tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg     5580

tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca     5640

gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc     5700

cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc     5760

cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat     5820

atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt     5880

attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt     5940

gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg     6000

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc     6060

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct     6120

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     6180

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag     6240

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg     6300

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     6360

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     6420

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     6480

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     6540

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     6600

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     6660

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     6720

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     6780

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     6840

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     6900

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     6960

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     7020

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     7080

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     7140

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     7200

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     7260

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     7320

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     7380

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     7440

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     7500

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     7560

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     7620

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     7680

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     7740

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     7800

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     7860

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     7920

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     7980

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     8040

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     8100

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     8160

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     8220

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat     8280

taatg                                                                 8285


<210>  22
<211>  7095
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  22
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagccagtg tttaccattg cagaatgtac atgcgactga aagggtgagg aaacctggga      240

aatgtcagtt cctcaaatac agagaacact gagggaagga tgagaaataa atgtgaaagc      300

agacatgaat ggtaattgac agaaggaaac taggatgtgt ccagtaaatg aataattaca      360

gtgtgcagtg attattgcaa tgattaatgt atgataagat aatatgaaaa cacagaattc      420

aaacagcagt gaactgagat tagaattgtg gagagcactg gcatttaaga atgtcacact      480

tagaatgtgt ctctaggcat tgttctgtgc atatatcatc tcaatattca ttatctgaaa      540

attatgaatt aggtacaaag ctcaaataat ttattttttc aggttagcaa gaactttttt      600

tttttttttc tgagatagag cattgctatg gttgcccagg ctggagtgca atggcatgat      660

ccaggctcac tgcaacatct gcctcccagg ttcaagcgat tctcctgcct cagcctccca      720

agtagctggc actacaggca tgtgccacca ccatgcctgg ctaattttct atttttagta      780

gaccgcggga acagagaaac aggagaatat gggccaaaca ggatatctgt ggtaagcagt      840

tcctgccccg gctcagggcc aagaacagtt ggaacagcag aatatgggcc aaacaggata      900

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg      960

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     1020

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     1080

gcttctgctc cccgagctct atataagcag agctcgttta gtgaaccgtc agatcgcctg     1140

gagacgccat ccacgctgtt ttgacttcca tagaaggcgg ccgcgccgcc accatggtga     1200

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     1260

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     1320

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     1380

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     1440

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     1500

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     1560

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     1620

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     1680

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     1740

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     1800

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     1860

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag taacctgcag     1920

ggagcatctt accgccattt attcccatat ttgttctgtt tttcttgatt tgggtataca     1980

tttaaatgtt aataaaacaa aatggtgggg caatcattta catttttagg gatatgtaat     2040

tactagttca ggtgtattgc cacaagacaa acatgttaag aaactttccc gttatttacg     2100

ctctgttcct gttaatcaac ctctggatta caaaatttgt gaaagattga ctgatattct     2160

taactatgtt gctcctttta cgctgtgtgg atatgctgct ttatagcctc tgtatctagc     2220

tattgcttcc cgtacggctt tcgttttctc ctccttgtat aaatcctggt tgctgtctct     2280

tttagaggag ttgtggcccg ttgtccgtca acgtggcgtg gtgtgctctg tgtttgctga     2340

cgcaaccccc actggctggg gcattgccac cacctgtcaa ctcctttctg ggactttcgc     2400

tttccccctc ccgatcgcca cggcagaact catcgccgcc tgccttgccc gctgctggac     2460

aggggctagg ttgctgggca ctgataattc cgtggtgttg tctgtgcctt ctagttgcca     2520

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     2580

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     2640

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     2700

tgctggggat gcggtgggct ctatggcagg gcaagttaag ggaatagtgg aatgaaggtt     2760

catttttcat tctcacaaac taatgaaacc ctgcttatct taaaccaacc tgctcactgg     2820

agcagggagg acaggaccag cataaaaggc agggcagagt cgactgttgc ttacactttc     2880

ttctgacata acagtgttca ctagcaacct caaacagaca ccatggtgca tctgactcct     2940

gaggagaaga ctgctgtcaa tgccctgtgg ggcaaagtga acgtggatgc agttggtggt     3000

gaggccctgg gcaggttggt atcaaggtta taagagaggc tcaaggaggc aaatggaaac     3060

tgggcatgtg tagacagaga agactcttgg gtttctgata ggcactgact ctctgtccct     3120

tgggctgttt tcctaccctc agattactgg tggtctaccc ttggacccag aggttctttg     3180

agtcctttgg ggatctgtcc tctcctgatg ctgttatggg caaccctaag gtgaaggctc     3240

atggcaagaa ggtgctaggt gcctttagtg atggcctggc tcacctggac aacctcaagg     3300

gcactttttc tcagctgagt gagctgcctc gaggtcgacg tagataagta gcatggcggg     3360

ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct     3420

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     3480

gcctcagtga gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg     3540

cccttcccaa cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg     3600

gtaatattgt tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa     3660

gtgatgttat tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga     3720

ctcttttact cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt     3780

tcctgtctaa aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg     3840

aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta     3900

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     3960

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     4020

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     4080

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     4140

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     4200

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     4260

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta     4320

acgtttacaa tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta     4380

tcaaccgggg tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt     4440

gtttgctcca gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag     4500

ctaccctctc cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt     4560

tgactgtctc cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg     4620

catttaaaat atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc     4680

ccgcaaaagt attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg     4740

aggctttatt gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg     4800

gaatcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg     4860

gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc     4920

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc     4980

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc     5040

gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt     5100

ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt     5160

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca     5220

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt     5280

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga     5340

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa     5400

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct     5460

gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat     5520

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga     5580

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc     5640

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat     5700

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa     5760

cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac     5820

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa     5880

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc     5940

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc     6000

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag     6060

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta     6120

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa     6180

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc     6240

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat     6300

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga     6360

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt     6420

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata     6480

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac     6540

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg     6600

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg     6660

tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag     6720

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct     6780

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc     6840

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt     6900

ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg     6960

tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga     7020

gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg     7080

gccgattcat taatg                                                      7095


<210>  23
<211>  7809
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  23
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagccagtg tttaccattg cagaatgtac atgcgactga aagggtgagg aaacctggga      240

aatgtcagtt cctcaaatac agagaacact gagggaagga tgagaaataa atgtgaaagc      300

agacatgaat ggtaattgac agaaggaaac taggatgtgt ccagtaaatg aataattaca      360

gtgtgcagtg attattgcaa tgattaatgt atgataagat aatatgaaaa cacagaattc      420

aaacagcagt gaactgagat tagaattgtg gagagcactg gcatttaaga atgtcacact      480

tagaatgtgt ctctaggcat tgttctgtgc atatatcatc tcaatattca ttatctgaaa      540

attatgaatt aggtacaaag ctcaaataat ttattttttc aggttagcaa gaactttttt      600

tttttttttc tgagatagag cattgctatg gttgcccagg ctggagtgca atggcatgat      660

ccaggctcac tgcaacatct gcctcccagg ttcaagcgat tctcctgcct cagcctccca      720

agtagctggc actacaggca tgtgccacca ccatgcctgg ctaattttct atttttagta      780

gacgagatcg agaccatcct ggctaacaca gtgaaacccc gtctctacta aaaaaataca      840

aaaaattagc cgggcttggt ggcgggtgcc tgtagtccca gctactatgg aggctgaggc      900

gggagaatgg cgtgaacgcg gggggcggag cttgcagtga gcagagatca ggggccactg      960

cactccagcc tgggcgacag agagagactc tgtctcaaaa aaaagaaaaa aaaaatttag     1020

tagactagct aaaaaaatcc agagatagtt attgatgcat atgtaaaagt cttccaatat     1080

ttacaagtac aatgaaaaaa aaataacctt gaattaagtg tagaactcat tgacaatgtt     1140

tcaaaggatg tgagggataa actaaaattt gggcagtaca tgctgttcct gtgtacttgg     1200

aacagaggga gaaaatctgg gctggaaata ttgttatagg agttagcaca tgaaggtgac     1260

aactaaatta tttggagtag atggagtcac cagcacatgt gaatagtttt agaatgaaat     1320

gacccaagat agaactttgg agagccccca aatttaaata aaatcagtat aagagaagag     1380

gaagaaacca aatggtatac tagtctaaat tgtttcttag tgacaaaaga ataacctgaa     1440

tattagatta gctgcctata tgctctctga atcaatttca ttcaacatgc aacagtccgc     1500

gggaacagag aaacaggaga atatgggcca aacaggatat ctgtggtaag cagttcctgc     1560

cccggctcag ggccaagaac agttggaaca gcagaatatg ggccaaacag gatatctgtg     1620

gtaagcagtt cctgccccgg ctcagggcca agaacagatg gtccccagat gcggtcccgc     1680

cctcagcagt ttctagagaa ccatcagatg tttccagggt gccccaagga cctgaaatga     1740

ccctgtgcct tatttgaact aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct     1800

gctccccgag ctctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg     1860

ccatccacgc tgttttgact tccatagaag gcggccgcgc cgccaccatg gtgagcaagg     1920

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg     1980

gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc     2040

tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc     2100

tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct     2160

tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg     2220

gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg     2280

agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca     2340

actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga     2400

acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc     2460

agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc     2520

agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg     2580

tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaacct gcagggagca     2640

tcttaccgcc atttattccc atatttgttc tgtttttctt gatttgggta tacatttaaa     2700

tgttaataaa acaaaatggt ggggcaatca tttacatttt tagggatatg taattactag     2760

ttcaggtgta ttgccacaag acaaacatgt taagaaactt tcccgttatt tacgctctgt     2820

tcctgttaat caacctctgg attacaaaat ttgtgaaaga ttgactgata ttcttaacta     2880

tgttgctcct tttacgctgt gtggatatgc tgctttatag cctctgtatc tagctattgc     2940

ttcccgtacg gctttcgttt tctcctcctt gtataaatcc tggttgctgt ctcttttaga     3000

ggagttgtgg cccgttgtcc gtcaacgtgg cgtggtgtgc tctgtgtttg ctgacgcaac     3060

ccccactggc tggggcattg ccaccacctg tcaactcctt tctgggactt tcgctttccc     3120

cctcccgatc gccacggcag aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     3180

taggttgctg ggcactgata attccgtggt gttgtctgtg ccttctagtt gccagccatc     3240

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     3300

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     3360

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     3420

ggatgcggtg ggctctatgg cagggcaagt taagggaata gtggaatgaa ggttcatttt     3480

tcattctcac aaactaatga aaccctgctt atcttaaacc aacctgctca ctggagcagg     3540

gaggacagga ccagcataaa aggcagggca gagtcgactg ttgcttacac tttcttctga     3600

cataacagtg ttcactagca acctcaaaca gacaccatgg tgcatctgac tcctgaggag     3660

aagactgctg tcaatgccct gtggggcaaa gtgaacgtgg atgcagttgg tggtgaggcc     3720

ctgggcaggt tggtatcaag gttataagag aggctcaagg aggcaaatgg aaactgggca     3780

tgtgtagaca gagaagactc ttgggtttct gataggcact gactctctgt cccttgggct     3840

gttttcctac cctcagatta ctggtggtct acccttggac ccagaggttc tttgagtcct     3900

ttggggatct gtcctctcct gatgctgtta tgggcaaccc taaggtgaag gctcatggca     3960

agaaggtgct aggtgccttt agtgatggcc tggctcacct ggacaacctc aagggcactt     4020

tttctcagct gagtgagctg cctcgaggtc gacgtagata agtagcatgg cgggttaatc     4080

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4140

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     4200

gtgagcgagc gagcgcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     4260

ccaacagttg cgcagcctga atggcgaatg gcgattccgt tgcaatggct ggcggtaata     4320

ttgttctgga tattaccagc aaggccgata gtttgagttc ttctactcag gcaagtgatg     4380

ttattactaa tcaaagaagt attgcgacaa cggttaattt gcgtgatgga cagactcttt     4440

tactcggtgg cctcactgat tataaaaaca cttctcagga ttctggcgta ccgttcctgt     4500

ctaaaatccc tttaatcggc ctcctgttta gctcccgctc tgattctaac gaggaaagca     4560

cgttatacgt gctcgtcaaa gcaaccatag tacgcgccct gtagcggcgc attaagcgcg     4620

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct     4680

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta     4740

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa     4800

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct     4860

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc     4920

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg     4980

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgttt     5040

acaatttaaa tatttgctta tacaatcttc ctgtttttgg ggcttttctg attatcaacc     5100

ggggtacata tgattgacat gctagtttta cgattaccgt tcatcgattc tcttgtttgc     5160

tccagactct caggcaatga cctgatagcc tttgtagaga cctctcaaaa atagctaccc     5220

tctccggcat gaatttatca gctagaacgg ttgaatatca tattgatggt gatttgactg     5280

tctccggcct ttctcacccg tttgaatctt tacctacaca ttactcaggc attgcattta     5340

aaatatatga gggttctaaa aatttttatc cttgcgttga aataaaggct tctcccgcaa     5400

aagtattaca gggtcataat gtttttggta caaccgattt agctttatgc tctgaggctt     5460

tattgcttaa ttttgctaat tctttgcctt gcctgtatga tttattggat gttggaatcg     5520

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatggtgcac     5580

tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc     5640

cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac     5700

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg     5760

aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta     5820

gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta     5880

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     5940

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc     6000

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga     6060

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct     6120

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg     6180

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta     6240

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat     6300

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt     6360

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga     6420

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga     6480

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga     6540

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc     6600

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc     6660

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg     6720

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat     6780

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata     6840

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     6900

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     6960

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     7020

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     7080

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct     7140

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc     7200

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt     7260

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg     7320

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct     7380

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag     7440

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag     7500

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg     7560

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg     7620

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac     7680

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt     7740

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     7800

tcattaatg                                                             7809


<210>  24
<211>  6726
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  24
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctacgtactt taggcttgta atgtgtttat atacagtgaa atgtcaagtt ctttctttat      240

atttctttct ttcttttttt tcctcagcct cagagttttc cacatgccct tcctactttc      300

aggaacttct ttctccaaac gtcttctgcc tggctccatc aaatcataaa ggacccactt      360

caaatgccat cactcactac catttcacaa ttcgcacttt ctttctttgt cctttttttt      420

tttagtaaaa caagtttata aaaaattgaa ggaataaatg aatggctact tcataggcag      480

agtagacgca agggctactg gttgccgatt tttattgtta tttttcaata gtatgctaaa      540

caaggggtag attatttatg ctgcccattt ttagaccata aaagataact tcctgatgtt      600

gccatggcat ttttttcctt ttaattttat ttcatttcat tttaatttcg aaggtacatg      660

tgcaggatgt gcaggcttgt tacatgggta aatgtgtgtc tttctggcct tttagccatc      720

tgtatcaatg agcagatata agctttacac aggatcatga aggatgaaag aatttcacca      780

atccgcggga acagagaaac aggagaatat gggccaaaca ggatatctgt ggtaagcagt      840

tcctgccccg gctcagggcc aagaacagtt ggaacagcag aatatgggcc aaacaggata      900

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg      960

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     1020

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     1080

gcttctgctc cccgagctct atataagcag agctcgttta gtgaaccgtc agatcgcctg     1140

gagacgccat ccacgctgtt ttgacttcca tagaaggcgg ccgcgccgcc accatggtga     1200

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     1260

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     1320

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     1380

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     1440

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     1500

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     1560

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     1620

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     1680

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     1740

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     1800

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     1860

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag taacctgcag     1920

ggataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     1980

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     2040

ccgtatggct ttcattttct cctccttgta taaatcctgg ttagttcttg ccacggcgga     2100

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     2160

ttccgtggtg tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattctagc     2220

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa     2280

caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga gatgtgggag     2340

gttttttaaa gcgaattcag gcctcactgg agctagagac aagaaggtaa aaaacggctg     2400

acaaaagaag tcctggtatc ctctatgatg ggagaaggaa actagctaaa gggaagaata     2460

aattagagaa aaactggaat gactgaatcg gaacaaggca aaggctataa aaaaaattag     2520

cagtatcctc ttgggggccc cttccccaca ctatctcaat gcaaatatct gtctgaaacg     2580

gtccctggct aaactccacc catgggttgg ccagccttgc cttgaccaat agccttgaca     2640

aggcaaactt gaccaatagt cttagagtat ccagtgaggc caggggccgg cggctggcta     2700

gggatgaaga ataaaaggaa gcacccttca gcagttccac acactcgctt ctggaacgtc     2760

tgaggttatc aataagctcc tagtccagac gccatgggtc atttcacaga ggaggacaag     2820

gctactatca caagcctgtg gggcaaggtg aatgtggaag atgctggagg agaaaccctg     2880

ggaaggtagg ctctggtgac caggacaagg gagggaagga aggaccctgt gcctggcaaa     2940

agtccaggtc gcttctcact cgaggtcgac gtagataagt agcatggcgg gttaatcatt     3000

aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     3060

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     3120

agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca     3180

acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg     3240

ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta     3300

ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac     3360

tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta     3420

aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt     3480

tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg     3540

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct     3600

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat     3660

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt     3720

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg     3780

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac     3840

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta     3900

aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca     3960

atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg     4020

gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc     4080

agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct     4140

ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct     4200

ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa     4260

tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag     4320

tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat     4380

tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct     4440

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     4500

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc     4560

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     4620

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa     4680

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac     4740

gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat     4800

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg     4860

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc     4920

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga     4980

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga     5040

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg     5100

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc     5160

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac     5220

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact     5280

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca     5340

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg     5400

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact     5460

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg     5520

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg     5580

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat     5640

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc     5700

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat     5760

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt     5820

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     5880

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     5940

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     6000

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt     6060

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     6120

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     6180

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     6240

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     6300

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     6360

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     6420

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     6480

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     6540

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     6600

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     6660

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     6720

ttaatg                                                                6726


<210>  25
<211>  6991
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  25
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctacgtactt taggcttgta atgtgtttat atacagtgaa atgtcaagtt ctttctttat      240

atttctttct ttcttttttt tcctcagcct cagagttttc cacatgccct tcctactttc      300

aggaacttct ttctccaaac gtcttctgcc tggctccatc aaatcataaa ggacccactt      360

caaatgccat cactcactac catttcacaa ttcgcacttt ctttctttgt cctttttttt      420

tttagtaaaa caagtttata aaaaattgaa ggaataaatg aatggctact tcataggcag      480

agtagacgca agggctactg gttgccgatt tttattgtta tttttcaata gtatgctaaa      540

caaggggtag attatttatg ctgcccattt ttagaccata aaagataact tcctgatgtt      600

gccatggcat ttttttcctt ttaattttat ttcatttcat tttaatttcg aaggtacatg      660

tgcaggatgt gcaggcttgt tacatgggta aatgtgtgtc tttctggcct tttagccatc      720

tgtatcaatg agcagatata agctttacac aggatcatga aggatgaaag aatttcacca      780

atccgcggga acagagaaac aggagaatat gggccaaaca ggatatctgt ggtaagcagt      840

tcctgccccg gctcagggcc aagaacagtt ggaacagcag aatatgggcc aaacaggata      900

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg      960

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     1020

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     1080

gcttctgctc cccgagctct atataagcag agctcgttta gtgaaccgtc agatcgcctg     1140

gagacgccat ccacgctgtt ttgacttcca tagaaggcgg ccgcgccgcc accatggtga     1200

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     1260

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     1320

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     1380

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     1440

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     1500

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     1560

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     1620

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     1680

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     1740

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     1800

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     1860

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag taacctgcag     1920

ggataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     1980

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     2040

ccgtatggct ttcattttct cctccttgta taaatcctgg ttagttcttg ccacggcgga     2100

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     2160

ttccgtggtg tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattctagc     2220

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa     2280

caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga gatgtgggag     2340

gttttttaaa gcgaattcgt aaatacactt gcaaaggagg atgtttttag tagcaatttg     2400

tactgatggt atggggccaa gagatatatc ttagagggag ggctgagggt ttgaagtcca     2460

actcctaagc cagtgccaga agagccaagg acaggtacgg ctgtcatcac ttagacctca     2520

ccctgtggag ccacacccta gggttggcca atctactccc aggagcaggg agggcaggag     2580

ccagggctgg gcataaaagt cagggcagag ccatctattg cttacactcg cttctggaac     2640

gtctgaggtt atcaataagc tcctagtcca gacgccatgg gtcatttcac agaggaggac     2700

aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg aggagaaacc     2760

ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc tgtgcctggc     2820

aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac tgttcttgtc     2880

aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac agctttggca     2940

acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat ggcaagaagg     3000

tgctgacttc cttgggagat gccacaaagc acctggatga tctcaagggc acctttgccc     3060

agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc aaggtgagtc     3120

caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa cggagtattg     3180

atctgagcac agcagggtgt gagctgtttg aagatactgg ggtctcgagg tcgacgtaga     3240

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     3300

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     3360

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag     3420

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc     3480

gttgcaatgg ctggcggtaa tattgttctg gatattacca gcaaggccga tagtttgagt     3540

tcttctactc aggcaagtga tgttattact aatcaaagaa gtattgcgac aacggttaat     3600

ttgcgtgatg gacagactct tttactcggt ggcctcactg attataaaaa cacttctcag     3660

gattctggcg taccgttcct gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc     3720

tctgattcta acgaggaaag cacgttatac gtgctcgtca aagcaaccat agtacgcgcc     3780

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     3840

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     3900

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     3960

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     4020

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     4080

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     4140

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     4200

ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct tcctgttttt     4260

ggggcttttc tgattatcaa ccggggtaca tatgattgac atgctagttt tacgattacc     4320

gttcatcgat tctcttgttt gctccagact ctcaggcaat gacctgatag cctttgtaga     4380

gacctctcaa aaatagctac cctctccggc atgaatttat cagctagaac ggttgaatat     4440

catattgatg gtgatttgac tgtctccggc ctttctcacc cgtttgaatc tttacctaca     4500

cattactcag gcattgcatt taaaatatat gagggttcta aaaattttta tccttgcgtt     4560

gaaataaagg cttctcccgc aaaagtatta cagggtcata atgtttttgg tacaaccgat     4620

ttagctttat gctctgaggc tttattgctt aattttgcta attctttgcc ttgcctgtat     4680

gatttattgg atgttggaat cgcctgatgc ggtattttct ccttacgcat ctgtgcggta     4740

tttcacaccg catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc     4800

agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     4860

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     4920

catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     4980

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     5040

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     5100

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     5160

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     5220

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     5280

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     5340

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc     5400

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     5460

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5520

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     5580

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     5640

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt     5700

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     5760

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     5820

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     5880

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     5940

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     6000

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     6060

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     6120

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     6180

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     6240

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     6300

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     6360

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     6420

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     6480

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     6540

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     6600

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     6660

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     6720

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     6780

tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg     6840

attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa     6900

cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc     6960

ctctccccgc gcgttggccg attcattaat g                                    6991


<210>  26
<211>  7724
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  26
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg      240

tagatctcac tttcagagaa aaacaaaaac aaactaacca aaagcaaaac agaaccaaaa      300

aaccaccata aatacttcct accctgttaa tggtccaata tgtcagaaac agcactgtgt      360

tagaaataaa gctgtctaaa gtacactaat attcgagtta taatagtgtg tggactatta      420

gtcaataaaa acaacccttg cctctttaga gttgttttcc atgtacacgc acatcttatg      480

tcttagagta agattccctg agaagtgaac ctagcattta tacaagataa ttaattctaa      540

tccacagtac ctgccaaaga acattctacc atcatcttta ctgagcatag aagagctacg      600

ccaaaaccct gggtcatcag ccagcacaca cacttatcca gtggtaaata cacatcatct      660

ggtgtataca tacatacctg aatatggaat caaatatttt tctaagatga aacagtcatg      720

atttatttca aataggtacg gataagtaga tatgaacaga gaaacaggag aatatgggcc      780

aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagttggaac      840

agcagaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc      900

aagaacagat ggtccccaga tgcggtcccg ccctcagcag tttctagaga accatcagat      960

gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac taaccaatca     1020

gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga gctctatata agcagagctc     1080

gtttagtgaa ccgtcagatc gcggccgcgc cgccaccatg gtgagcaagg gcgaggagct     1140

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt     1200

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat     1260

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg     1320

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc     1380

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     1440

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     1500

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag     1560

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat     1620

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     1680

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     1740

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     1800

cgggatcact ctcggcatgg acgagctgta caagtaggag catcttaccg ccatttattc     1860

ccatatttgt tctgtttttc ttgatttggg tatacattta aatgttaata aaacaaaatg     1920

gtggggcaat catttacatt tttagggata tgtaattact agttcaggtg tattgccaca     1980

agacaaacat gttaagaaac tttcccgtta tttacgctct gttcctgtta atcaacctct     2040

ggattacaaa atttgtgaaa gattgactga tattcttaac tatgttgctc cttttacgct     2100

gtgtggatat gctgctttat agcctctgta tctagctatt gcttcccgta cggctttcgt     2160

tttctcctcc ttgtataaat cctggttgct gtctctttta gaggagttgt ggcccgttgt     2220

ccgtcaacgt ggcgtggtgt gctctgtgtt tgctgacgca acccccactg gctggggcat     2280

tgccaccacc tgtcaactcc tttctgggac tttcgctttc cccctcccga tcgccacggc     2340

agaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctaggttgc tgggcactga     2400

taattccgtg gtgttgtctg tgccttctag ttgccagcca tctgttgttt gcccctcccc     2460

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     2520

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     2580

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat     2640

ggctagatgt ccccagttaa cctcctattt gacaccactg attaccccat tgatagtcac     2700

actttgggtt gtaagtgact ttttatttat ttgtattttt gactgcatta agaggtctct     2760

agttttttat ctcttgtttc ccaaaaccta ataagtaact aatgcacaga gcacattgat     2820

ttgtatttat tctattttta gacataattt attagcatgc atgagcaaat taagaaaaac     2880

aacaacaaat gaatgcatat atatgtatat gtatgtgtgt atatatacac acatatatat     2940

atatattttt tcttttctta ccagaaggtt ttaatccaaa taaggagaag atatgcttag     3000

aaccgaggta gagttttcat ccattctgtc ctgtaagtat tttgcatatt ctggagacgc     3060

aggaagagat ccatctacat atcccaaagc tgaattatgg tagacaaaac tcttccactt     3120

ttagtgcatc aacttcttat ttgtgtaata agaaaattgg gaaaacgatc ttcaatatgc     3180

ttaccaagct gtgattccaa atattacgta aatacacttg caaaggagga tgtttttagt     3240

agcaatttgt actgatggta tggggccaag agatatatct tagagggagg gctgagggtt     3300

tgaagtccaa ctcctaagcc agtgccagaa gagccaagga caggtacggc tgtcatcact     3360

tagacctcac cctgtggagc cacaccctag ggttggccaa tctactccca ggagcaggga     3420

gggcaggagc cagggctggg cataaaagtc agggcagagc catctattgc ttacactcgc     3480

ttctggaacg tctgaggtta tcaataagct cctagtccag acgccatggg tcatttcaca     3540

gaggaggaca aggctactat cacaagcctg tggggcaagg tgaatgtgga agatgctgga     3600

ggagaaaccc tgggaaggta ggctctggtg accaggacaa gggagggaag gaaggaccct     3660

gtgcctggca aaagtccagg tcgcttctca ggatttgtgg caccttctga ctgtcaaact     3720

gttcttgtca atctcacagg ctcctggttg tctacccatg gacccagagg ttctttgaca     3780

gctttggcaa cctgtcctct gcctctgcca tcatgggcaa ccccaaagtc aaggcacatg     3840

gcaagaaggt gctgacttcc ttgggagatg ccacaaagca cctggatgat ctcaagggca     3900

cctttgccca gctgagtgaa ctgcactgtg acaagctgca tgtggatcct gagaacttca     3960

aggtcgacgt agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga     4020

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     4080

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgccagctgg     4140

cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc     4200

gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta ccagcaaggc     4260

cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa gaagtattgc     4320

gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca ctgattataa     4380

aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa tcggcctcct     4440

gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg tcaaagcaac     4500

catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     4560

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     4620

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     4680

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     4740

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     4800

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     4860

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     4920

aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt gcttatacaa     4980

tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt gacatgctag     5040

ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc aatgacctga     5100

tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt tatcagctag     5160

aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc acccgtttga     5220

atctttacct acacattact caggcattgc atttaaaata tatgagggtt ctaaaaattt     5280

ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc ataatgtttt     5340

tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg ctaattcttt     5400

gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt tctccttacg     5460

catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg ctctgatgcc     5520

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     5580

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     5640

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     5700

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     5760

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     5820

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     5880

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     5940

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     6000

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     6060

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     6120

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     6180

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     6240

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     6300

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     6360

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     6420

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     6480

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     6540

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     6600

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     6660

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     6720

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     6780

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     6840

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     6900

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     6960

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     7020

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     7080

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     7140

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7200

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7260

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     7320

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     7380

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     7440

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     7500

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     7560

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     7620

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca     7680

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg                      7724


<210>  27
<211>  8525
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  27
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg      240

tagatctaga tgaaacagtc atgatttatt tcaaataggt acggataagt agatattgag      300

gtaagcatta ggtcttatat tatgtaacac taatctatta ctgcgctgaa actgtggctt      360

tatagaaatt gttttcactg cactattgag aaattaagag ataatggcaa aagtcacaaa      420

gagtatattc aaaaagaagt atagcacttt ttccttagaa accactgcta actgaaagag      480

actaagattt gtcccgtcaa aaatcctgga cctatgccta aaacacattt cacaatccct      540

gaacttttca aaaattggta catgctttag ctttaaacta caggcctcac tggagctaga      600

gacaagaagg taaaaaacgg ctgacaaaag aagtcctggt atcctctatg atgggagaag      660

gaaactagct aaagggaaga ataaattaga gaaaaactgg aatgactgaa tcggaacaag      720

gcaaaggcta taaaaaaaat tagcagtatc ctcttggggg ccccttcccc acactatctc      780

aatgcaaata tctgtctgaa acggtccctg gctaaactcc acccatgggt tggccagcct      840

tgccttgaca aggcaaactt gaccaatagt cttagagtat ccagtgaggc caggggccgg      900

cggctggcta gggatgaaga ataaaaggaa gcacccttca gcagttccac acactcgctt      960

ctggaacgtc tgaggttatc aataagctcc tagtccagac gccatggtgc acctgactcc     1020

tgaggagaag tctgccgtta ctgccctgtg gggcaaggtg aacgtggatg aagttggtgg     1080

tgaggccctg ggcaggttgg tatcaaggtt acaagacagg tttaaggaga ccaatagaaa     1140

ctgggcatgt ggagacagag aagactcttg ggtttctgat aggcactgac tctctctgcc     1200

tattggtcta ttttcccacc cttaggctgc tggtggtcta cccttggacc cagaggttct     1260

ttgagtcctt tggggatctg tccactcctg atgctgttat gggcaaccct aaggtgaagg     1320

ctcatggcaa gaaagtgctc ggtgccttta gtgatggcct ggctcacctg gacaacctca     1380

agggcacctt tgcccagctg agtgagctgc actgtgacaa gctgcacgtg gatcctgaga     1440

acttcagggt gagtctatgg gacccttgat gttttctttc cccttctttt ctatggttaa     1500

gttcatgtca taggaagggg agaagtaaca gggtacacat attgaccaaa tcagggtaat     1560

tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt gtttatctta     1620

tttctaatac tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc     1680

tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt     1740

tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt catattgcta     1800

atagcagcta caatccagct accattctgc ttttatttta tggttgggat aaggctggat     1860

tattctgagt ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc     1920

acagctcctg ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattcac     1980

cccaccagtg caggctgcct atcagaaagt ggtggctggt gtggctaatg ccctggccca     2040

caagtatcac taagctcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc     2100

taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct     2160

aataaaaaac atttattttc attgcaatga tgtatttaaa ttatttctga atattttact     2220

aaaaagggaa tgtgggaggt cagtgcattt aaaacataaa gaaatgaaga gctagttcaa     2280

accttgggaa aatacactat atcttaaact ccatgaaaga aggtgaggct gcaaacagct     2340

aatgcacatt ggcaacagcc cctgatgcct atgccttatt catccctcag aaaaggattc     2400

aagtagaggc ttgatttgga ggttaaagtt ttgctatgct gtattttaca ttacttattg     2460

ttttagctgt cctcatgaat gtcttttcac tacccatttg cttatcctgc atctctcagc     2520

cttgactcca ctcagttctc ttgcttagag ataccacctt tcccctgaag tgttccttcc     2580

atgttttacg gcgagatggt ttctcctcgc ctggccactc agccttagtt gtctctgttg     2640

tcttatagag gtctacttga agaaggaaaa acagggggca tggtttgact gtcctgtgag     2700

cccttcttcc ctgcctcccc cactcacagt gacccggaat ctgcagtgct agtctcccgg     2760

aactatcact ctttcacagt ctgctttgga aggactgggc ttagtatgaa aagttaggac     2820

tgagaagaat ttgaaagggg gctttttgta gcttgatatt cactactgtc ttattaccct     2880

atcataggcc caccccaaat ggaagtccca ttcttcctca ggatgtttaa gattagcatt     2940

caggaagaga tcagaggtct gctggctccc ttatcatgtc ccttatggtg cttctggctc     3000

tgcagttatt agcatagtgt taccatcaac caccttaact tcatttttct tattcaatac     3060

ctagccgcgg gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca     3120

gttcctgccc cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga     3180

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc     3240

ggtcccgccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc     3300

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc     3360

gcgcttctgc tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatcgcg     3420

gccgcgccgc caccatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc     3480

tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg     3540

gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg     3600

tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc     3660

ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg     3720

agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg     3780

agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca     3840

acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg     3900

acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca     3960

gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc     4020

tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc     4080

gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg     4140

agctgtacaa gtaacctgca gggctcactg cccatgattc agagctttca aggataggct     4200

ttattctgca agcaatacaa ataataaatc tattctgctg agagatcaca catgattttc     4260

ttcagctctt ttttttacat ctttttaaat atatgagcca caaagggttt atattgaggg     4320

aagtgtgtat gtgtatttct gcatgcctgt ttgtgtttgt ggtgtgtgca tgctcctcat     4380

ttatttttat atgagatgtg cattttgatg agcaaataaa agcagtaaag acacttgtac     4440

acgggagttc tgcaagtggg agtaaatggt gtaggagaaa tccggtggga agaaagacct     4500

ctataggaca ggacttctca gaaacagatg ttttggaaga gatgggaaaa ggttcagtga     4560

agacctgggg gctggattga ttgcagctga gtagcaagga tggttcttaa ggaagggaaa     4620

gtgttccaag ctttaggaat tcaaggttta gtcaggtgta gcaattctat tttattagga     4680

ggaatactat ttctaatggc acttagcttt tcacagccct tgtggatgcc taagaaagtg     4740

aaattaatcc catgccctca agtgtcgacg tagataagta gcatggcggg ttaatcatta     4800

actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     4860

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     4920

gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa     4980

cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt     5040

tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat     5100

tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact     5160

cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa     5220

aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt     5280

atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg     5340

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     5400

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     5460

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     5520

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     5580

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     5640

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     5700

aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa     5760

tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg     5820

tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca     5880

gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc     5940

cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc     6000

cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat     6060

atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt     6120

attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt     6180

gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg     6240

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc     6300

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct     6360

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     6420

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag     6480

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg     6540

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     6600

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     6660

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     6720

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     6780

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     6840

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     6900

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     6960

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     7020

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     7080

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     7140

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     7200

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     7260

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     7320

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     7380

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     7440

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     7500

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     7560

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     7620

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     7680

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     7740

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     7800

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     7860

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     7920

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     7980

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     8040

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     8100

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     8160

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     8220

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     8280

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     8340

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     8400

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     8460

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat     8520

taatg                                                                 8525


<210>  28
<211>  8118
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  28
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctttttt ccttagaaac cactgctaac tgaaagagac      180

taagatttgt cccgtcaaaa atcctggacc tatgcctaaa acacatttca caatccctga      240

acttttcaaa aattggtaca tgctttagct ttaaactaca ggcctcactg gagctagaga      300

caagaaggta aaaaacggct gacaaaagaa gtcctggtat cctctatgat gggagaagga      360

aactagctaa agggaagaat aaattagaga aaaactggaa tgactgaatc ggaacaaggc      420

aaaggctata aaaaaaatta gcagtatcct cttgggggcc ccttccccac actatctcaa      480

tgcaaatatc tgtctgaaac ggtccctggc taaactccac ccatgggttg gccagccttg      540

ccttgacaag gcaaacttga ccaatagtct tagagtatcc agtgaggcca ggggccggcg      600

gctggctagg gatgaagaat aaaaggaagc acccttcagc agttccacac actcgcttct      660

ggaacgtctg aggttatcaa taagctccta gtccagacgc catggtgcac ctgactcctg      720

aggagaagtc tgccgttact gccctgtggg gcaaggtgaa cgtggatgaa gttggtggtg      780

aggccctggg caggttggta tcaaggttac aagacaggtt taaggagacc aatagaaact      840

gggcatgtgg agacagagaa gactcttggg tttctgatag gcactgactc tctctgccta      900

ttggtctatt ttcccaccct taggctgctg gtggtctacc cttggaccca gaggttcttt      960

gagtcctttg gggatctgtc cactcctgat gctgttatgg gcaaccctaa ggtgaaggct     1020

catggcaaga aagtgctcgg tgcctttagt gatggcctgg ctcacctgga caacctcaag     1080

ggcacctttg cccagctgag tgagctgcac tgtgacaagc tgcacgtgga tcctgagaac     1140

ttcagggtga gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt     1200

tcatgtcata ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt     1260

tgcatttgta attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt     1320

tctaatactt tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc     1380

tttgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc     1440

tgcatataaa tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat     1500

agcagctaca atccagctac cattctgctt ttattttatg gttgggataa ggctggatta     1560

ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac     1620

agctcctggg caacgtgctg gtctgtgtgc tggcccatca ctttggcaaa gaattcaccc     1680

caccagtgca ggctgcctat cagaaagtgg tggctggtgt ggctaatgcc ctggcccaca     1740

agtatcacta agctcgcttt cttgctgtcc aatttctatt aaaggttcct ttgttcccta     1800

agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga ttctgcctaa     1860

taaaaaacat ttattttcat tgcaatgatg tatttaaatt atttctgaat attttactaa     1920

aaagggaatg tgggaggtca gtgcatttaa aacataaaga aatgaagagc tagttcaaac     1980

cttgggaaaa tacactatat cttaaactcc atgaaagaag gtgaggctgc aaacagctaa     2040

tgcacattgg caacagcccc tgatgcctat gccttattca tccctcagaa aaggattcaa     2100

gtagaggctt gatttggagg ttaaagtttt gctatgctgt attttacatt acttattgtt     2160

ttagctgtcc tcatgaatgt cttttcacta cccatttgct tatcctgcat ctctcagcct     2220

tgactccact cagttctctt gcttagagat accacctttc ccctgaagtg ttccttccat     2280

gttttacggc gagatggttt ctcctcgcct ggccactcag ccttagttgt ctctgttgtc     2340

ttatagaggt ctacttgaag aaggaaaaac agggggcatg gtttgactgt cctgtgagcc     2400

cttcttccct gcctccccca ctcacagtga cccggaatct gcagtgctag tctcccggaa     2460

ctatcactct ttcacagtct gctttggaag gactgggctt agtatgaaaa gttaggactg     2520

agaagaattt gaaagggggc tttttgtagc ttgatattca ctactgtctt attaccctat     2580

cataggccca ccccaaatgg aagtcccatt cttcctcagg atgtttaaga ttagcattca     2640

ggaagagatc agaggtctgc tggctccctt atcatgtccc ttatggtgct tctggctctg     2700

cagttattag catagtgtta ccatcaacca ccttaacttc atttttctta ttcaatacct     2760

agccgcggga acagagaaac aggagaatat gggccaaaca ggatatctgt ggtaagcagt     2820

tcctgccccg gctcagggcc aagaacagtt ggaacagcag aatatgggcc aaacaggata     2880

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg     2940

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     3000

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     3060

gcttctgctc cccgagctct atataagcag agctcgttta gtgaaccgtc agatcgcggc     3120

cgcgccgcca ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg     3180

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc     3240

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg     3300

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc     3360

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag     3420

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     3480

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     3540

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac     3600

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc     3660

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     3720

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc     3780

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     3840

ctgtacaagt aagctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     3900

taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg     3960

gggagatgtg ggaggttttt taaagccctg caggatgggt catttcacag aggaggacaa     4020

ggctactatc acaagcctgt ggggcaaggt gaatgtggaa gatgctggag gagaaaccct     4080

gggaaggtag gctctggtga ccaggacaag ggagggaagg aaggaccctg tgcctggcaa     4140

aagtccaggt cgcttctcag gatttgtggc accttctgac tgtcaaactg ttcttgtcaa     4200

tctcacaggc tcctggttgt ctacccatgg acccagaggt tctttgacag ctttggcaac     4260

ctgtcctctg cctctgccat catgggcaac cccaaagtca aggcacatgg caagaaggtg     4320

ctgacttcct tgggagatgc cacaaagcac ctggatgatc tcaagggcac ctttgcccag     4380

ctgagtgaac tgcagtcgac aggaacccct agtgatggag ttggccactc cctctctgcg     4440

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4500

ggcggcctca gtgagcgagc gagcgcgcag ctggcgtaat agcgaagagg cccgcaccga     4560

tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgattccgtt gcaatggctg     4620

gcggtaatat tgttctggat attaccagca aggccgatag tttgagttct tctactcagg     4680

caagtgatgt tattactaat caaagaagta ttgcgacaac ggttaatttg cgtgatggac     4740

agactctttt actcggtggc ctcactgatt ataaaaacac ttctcaggat tctggcgtac     4800

cgttcctgtc taaaatccct ttaatcggcc tcctgtttag ctcccgctct gattctaacg     4860

aggaaagcac gttatacgtg ctcgtcaaag caaccatagt acgcgccctg tagcggcgca     4920

ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta     4980

gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt     5040

caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac     5100

cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt     5160

tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga     5220

acaacactca accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg     5280

gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata     5340

ttaacgttta caatttaaat atttgcttat acaatcttcc tgtttttggg gcttttctga     5400

ttatcaaccg gggtacatat gattgacatg ctagttttac gattaccgtt catcgattct     5460

cttgtttgct ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa     5520

tagctaccct ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg     5580

atttgactgt ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca     5640

ttgcatttaa aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt     5700

ctcccgcaaa agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct     5760

ctgaggcttt attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg     5820

ttggaatcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat     5880

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     5940

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     6000

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     6060

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat     6120

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt     6180

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct     6240

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc     6300

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     6360

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     6420

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     6480

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     6540

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     6600

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     6660

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     6720

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     6780

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     6840

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     6900

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     6960

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     7020

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     7080

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     7140

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     7200

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     7260

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     7320

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     7380

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     7440

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     7500

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     7560

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     7620

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     7680

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     7740

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     7800

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     7860

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     7920

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     7980

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     8040

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     8100

ttggccgatt cattaatg                                                   8118


<210>  29
<211>  7963
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  29
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg      240

tagatcttga aacagtcatg atttatttca aataggtacg gataagtaga tattgaggta      300

agcattaggt cttatattat gtaacactaa tctattactg cgctgaaact gtggctttat      360

agaaattgtt ttcactgcac tattgagaaa ttaagagata atggcaaaag tcacaaagag      420

tatattcaaa aagaagtata gcactttttc cttagaaacc actgctaact gaaagagact      480

aagatttgtc ccgtcaaaaa tcctggacct atgcctaaaa cacatttcac aatccctgaa      540

cttttcaaaa attggtacat gctttagctt taaactacag gcctcactgg agctagagac      600

aagaaggtaa aaaacggctg acaaaagaag tcctggtatc ctctatgatg ggagaaggaa      660

actagctaaa gggaagaata aattagagaa aaactggaat gactgaatcg gaacaaggca      720

aaggctataa aaaaaattag cagtatcctc ttgggggccc cttccccaca ctatctcaat      780

gcaaatatct gtctgaaacg gtccctggct aaactccacc catgggttgg ccagccttgc      840

cttgacaagg caaacttgac caatagtctt agagtatcca gtgaggccag gggccggcgg      900

ctggctaggg atgaagaata aaaggaagca cccttcagca gttccacaca ctcgcttctg      960

gaacgtctga ggttatcaat aagctcctag tccagacgcc atggtgcacc tgactcctga     1020

ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag ttggtggtga     1080

ggccctgggc aggttggtat caaggttaca agacaggttt aaggagacca atagaaactg     1140

ggcatgtgga gacagagaag actcttgggt ttctgatagg cactgactct ctctgcctat     1200

tggtctattt tcccaccctt aggctgctgg tggtctaccc ttggacccag aggttctttg     1260

agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc     1320

atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg     1380

gcacctttgc ccagctgagt gagctgcact gtgacaagct gcacgtggat cctgagaact     1440

tcagggtgag tctatgggac ccttgatgtt ttctttcccc ttcttttcta tggttaagtt     1500

catgtcatag gaaggggaga agtaacaggg tacacatatt gaccaaatca gggtaatttt     1560

gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt     1620

ctaatacttt ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct     1680

ttgcaccatt ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct     1740

gcatataaat atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata     1800

gcagctacaa tccagctacc attctgcttt tattttatgg ttgggataag gctggattat     1860

tctgagtcca agctaggccc ttttgctaat catgttcata cctcttatct tcctcccaca     1920

gctcctgggc aacgtgctgg tctgtgtgct ggcccatcac tttggcaaag aattcacccc     1980

accagtgcag gctgcctatc agaaagtggt ggctggtgtg gctaatgccc tggcccacaa     2040

gtatcactaa gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa     2100

gtccaactac taaactgggg gatattatga agggccttga gcatctggat tctgcctaat     2160

aaaaaacatt tattttcatt gctgcagtgc tagtctcccg gaactatcac tctttcacag     2220

tctgctttgg aaggactggg cttagtatga aaagttagga ctgagaagaa tttgaaaggg     2280

ggctttttgt agcttgatat tcactactgt cttattaccc tatcataggc ccaccccaaa     2340

tggaagtccc attcttcctc aggatgttta agattagcat tcaggaagag atcagaggtc     2400

tgctggctcc cttatcatgt cccttatggt gcttctggct ctgcaccgcg ggaacagaga     2460

aacaggagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg     2520

gccaagaaca gttggaacag cagaatatgg gccaaacagg atatctgtgg taagcagttc     2580

ctgccccggc tcagggccaa gaacagatgg tccccagatg cggtcccgcc ctcagcagtt     2640

tctagagaac catcagatgt ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt     2700

atttgaacta accaatcagt tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc     2760

tctatataag cagagctcgt ttagtgaacc gtcagatcgc ggccgcgccg ccaccatggt     2820

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga     2880

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa     2940

gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt     3000

gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca     3060

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa     3120

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa     3180

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct     3240

ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat     3300

caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca     3360

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct     3420

gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct     3480

ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca aggagggcag     3540

aggaagtctt ctaacatgcg gtgacgtgga ggagaatccg ggcccccctg caggaacttc     3600

aaggtgagtc caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa     3660

cggagtattg atctgagcac agcagggtgt gagctgtttg aagatactgg ggttgggggt     3720

gaagaaactg cagaggacta actgggctga gacccagtgg taatgtttta gggcctaagg     3780

agtgcctcta aaaatctaga tggacaattt tgactttgag aaaagagagg tggaaatgag     3840

gaaaatgact tttctttatt agattccagt agaaagaact ttcatctttc cctcattttt     3900

gttgttttaa aacatctatc tggaggcagg acaagtatgg tcgttaaaaa gatgcaggca     3960

gaaggcatat attggctcag tcaaagtggg gaactttggt ggccaaacat acattgctaa     4020

ggctattcct atatcagctg gacacatata aaatgctgct aatgcttcat tacaaactta     4080

tatcctttaa ttccagatgg gggcaaagta tgtccagggg tgaggaacaa ttgaaacatt     4140

tgggctggag tagattttga aagtcagctc tgtgtgtgtg tgtgtgtgtg cgcgcgcgcg     4200

tgtcgacgta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     4260

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     4320

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gccagctggc     4380

gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg     4440

aatggcgatt ccgttgcaat ggctggcggt aatattgttc tggatattac cagcaaggcc     4500

gatagtttga gttcttctac tcaggcaagt gatgttatta ctaatcaaag aagtattgcg     4560

acaacggtta atttgcgtga tggacagact cttttactcg gtggcctcac tgattataaa     4620

aacacttctc aggattctgg cgtaccgttc ctgtctaaaa tccctttaat cggcctcctg     4680

tttagctccc gctctgattc taacgaggaa agcacgttat acgtgctcgt caaagcaacc     4740

atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt     4800

gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct     4860

cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg     4920

atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag     4980

tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa     5040

tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga     5100

tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa     5160

atttaacgcg aattttaaca aaatattaac gtttacaatt taaatatttg cttatacaat     5220

cttcctgttt ttggggcttt tctgattatc aaccggggta catatgattg acatgctagt     5280

tttacgatta ccgttcatcg attctcttgt ttgctccaga ctctcaggca atgacctgat     5340

agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt atcagctaga     5400

acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca cccgtttgaa     5460

tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc taaaaatttt     5520

tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca taatgttttt     5580

ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc taattctttg     5640

ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt ctccttacgc     5700

atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg     5760

catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     5820

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     5880

ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt     5940

tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa     6000

atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca     6060

tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc     6120

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     6180

acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt     6240

acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt     6300

ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg     6360

ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact     6420

caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg     6480

ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga     6540

aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg     6600

aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa     6660

tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac     6720

aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc     6780

cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca     6840

ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga     6900

gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta     6960

agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     7020

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     7080

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     7140

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     7200

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     7260

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     7320

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     7380

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     7440

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     7500

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     7560

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     7620

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     7680

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     7740

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg     7800

cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc     7860

gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa     7920

tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atg                       7963


<210>  30
<211>  7553
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  30
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttccttaga aaccactgct aactgaaaga gactaagatt tgtcccgtca aaaatcctgg      240

acctatgcct aaaacacatt tcacaatccc tgaacttttc aaaaattggt acatgcttta      300

gctttaaact acaggcctca ctggagctag agacaagaag gtaaaaaacg gctgacaaaa      360

gaagtcctgg tatcctctat gatgggagaa ggaaactagc taaagggaag aataaattag      420

agaaaaactg gaatgactga atcggaacaa ggcaaaggct ataaaaaaaa ttagcagtat      480

cctcttgggg gccccttccc cacactatct caatgcaaat atctgtctga aacggtccct      540

ggctaaactc cacccatggg ttggccagcc ttgccttgac aaggcaaact tgaccaatag      600

tcttagagta tccagtgagg ccaggggccg gcggctggct agggatgaag aataaaagga      660

agcacccttc agcagttcca cacactcgct tctggaacgt ctgaggttat caataagctc      720

ctagtccaga cgccatggtg cacctgactc ctgaggagaa gtctgccgtt actgccctgt      780

ggggcaaggt gaacgtggat gaagttggtg gtgaggccct gggcaggttg gtatcaaggt      840

tacaagacag gtttaaggag accaatagaa actgggcatg tggagacaga gaagactctt      900

gggtttctga taggcactga ctctctctgc ctattggtct attttcccac ccttaggctg      960

ctggtggtct acccttggac ccagaggttc tttgagtcct ttggggatct gtccactcct     1020

gatgctgtta tgggcaaccc taaggtgaag gctcatggca agaaagtgct cggtgccttt     1080

agtgatggcc tggctcacct ggacaacctc aagggcacct ttgcccagct gagtgagctg     1140

cactgtgaca agctgcacgt ggatcctgag aacttcaggg tgagtctatg ggacccttga     1200

tgttttcttt ccccttcttt tctatggtta agttcatgtc ataggaaggg gagaagtaac     1260

agggtacaca tattgaccaa atcagggtaa ttttgcattt gtaattttaa aaaatgcttt     1320

cttcttttaa tatacttttt tgtttatctt atttctaata ctttccctaa tctctttctt     1380

tcagggcaat aatgatacaa tgtatcatgc ctctttgcac cattctaaag aataacagtg     1440

ataatttctg ggttaaggca atagcaatat ttctgcatat aaatatttct gcatataaat     1500

tgtaactgat gtaagaggtt tcatattgct aatagcagct acaatccagc taccattctg     1560

cttttatttt atggttggga taaggctgga ttattctgag tccaagctag gcccttttgc     1620

taatcatgtt catacctctt atcttcctcc cacagctcct gggcaacgtg ctggtctgtg     1680

tgctggccca tcactttggc aaagaattca ccccaccagt gcaggctgcc tatcagaaag     1740

tggtggctgg tgtggctaat gccctggccc acaagtatca ctaagctcgc tttcttgctg     1800

tccaatttct attaaaggtt cctttgttcc ctaagtccaa ctactaaact gggggatatt     1860

atgaagggcc ttgagcatct ggattctgcc taataaaaaa catttatttt cattgcaatg     1920

atgtatttaa attatttctg aatattttac taaaaaggga atgtgggagg ttgcagtgct     1980

agtctcccgg aactatcact ctttcacagt ctgctttgga aggactgggc ttagtatgaa     2040

aagttaggac tgagaagaat ttgaaagggg gctttttgta gcttgatatt cactactgtc     2100

ttattaccct atcataggcc caccccaaat ggaagtccca ttcttcctca ggatgtttaa     2160

gattagcatt caggaagaga tcagaggtct gctggctccc ttatcatgtc ccttatggtg     2220

cttctggctc tgcaccgcgg gaacagagaa acaggagaat atgggccaaa caggatatct     2280

gtggtaagca gttcctgccc cggctcaggg ccaagaacag ttggaacagc agaatatggg     2340

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt     2400

ccccagatgc ggtcccgccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc     2460

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc     2520

ttctgttcgc gcgcttctgc tccccgagct ctatataagc agagctcgtt tagtgaaccg     2580

tcagatcgcg gccgcgccgc caccatggtg agcaagggcg aggagctgtt caccggggtg     2640

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     2700

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     2760

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc     2820

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     2880

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     2940

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     3000

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     3060

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     3120

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     3180

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     3240

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     3300

ggcatggacg agctgtacaa ggagggcaga ggaagtcttc taacatgcgg tgacgtggag     3360

gagaatccgg gcccccctgc aggaacttca aggtgagtcc aggagatgtt tcagccctgt     3420

tgcctttagt ctcgaggcaa cttagacaac ggagtattga tctgagcaca gcagggtgtg     3480

agctgtttga agatactggg gttgggggtg aagaaactgc agaggactaa ctgggctgag     3540

acccagtggt aatgttttag ggcctaagga gtgcctctaa aaatctagat ggacaatttt     3600

gactttgaga aaagagaggt ggaaatgagg aaaatgactt ttctttatta gattccagta     3660

gaaagaactt tcatctttcc ctcatttttg ttgttttaaa acatctatct ggaggcagga     3720

caagtatggt cgttaaaaag atgcaggcag aaggcatata ttggctcagt caaagtgggg     3780

aactttggtg ggtcgacgta gataagtagc atggcgggtt aatcattaac tacaaggaac     3840

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3900

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3960

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     4020

ctgaatggcg aatggcgatt ccgttgcaat ggctggcggt aatattgttc tggatattac     4080

cagcaaggcc gatagtttga gttcttctac tcaggcaagt gatgttatta ctaatcaaag     4140

aagtattgcg acaacggtta atttgcgtga tggacagact cttttactcg gtggcctcac     4200

tgattataaa aacacttctc aggattctgg cgtaccgttc ctgtctaaaa tccctttaat     4260

cggcctcctg tttagctccc gctctgattc taacgaggaa agcacgttat acgtgctcgt     4320

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     4380

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     4440

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     4500

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     4560

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     4620

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     4680

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     4740

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt taaatatttg     4800

cttatacaat cttcctgttt ttggggcttt tctgattatc aaccggggta catatgattg     4860

acatgctagt tttacgatta ccgttcatcg attctcttgt ttgctccaga ctctcaggca     4920

atgacctgat agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt     4980

atcagctaga acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca     5040

cccgtttgaa tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc     5100

taaaaatttt tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca     5160

taatgttttt ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc     5220

taattctttg ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt     5280

ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc     5340

tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga     5400

cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc     5460

atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata     5520

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     5580

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     5640

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     5700

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     5760

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     5820

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     5880

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     5940

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     6000

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     6060

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     6120

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     6180

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     6240

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     6300

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     6360

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     6420

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     6480

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     6540

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     6600

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     6660

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     6720

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     6780

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     6840

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     6900

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     6960

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     7020

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     7080

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     7140

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     7200

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     7260

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     7320

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     7380

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     7440

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     7500

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atg            7553


<210>  31
<211>  8029
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  31
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg aggtaagcat      240

taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc tttatagaaa      300

ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca aagagtatat      360

tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag agactaagat      420

ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc ctgaactttt      480

caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta gagacaagaa      540

ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga aggaaactag      600

ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca aggcaaaggc      660

tataaaaaaa attagcagta tcctcttggg ggccccttcc ccacactatc tcaatgcaaa      720

tatctgtctg aaacggtccc tggctaaact ccacccatgg gttggccagc cttgccttga      780

caaggcaaac ttgaccaata gtcttagagt atccagtgag gccaggggcc ggcggctggc      840

tagggatgaa gaataaaagg aagcaccctt cagcagttcc acacactcgc ttctggaacg      900

tctgaggtta tcaataagct cctagtccag acgccatggt gcacctgact cctgaggaga      960

agtctgccgt tactgccctg tggggcaagg tgaacgtgga tgaagttggt ggtgaggccc     1020

tgggcaggtt ggtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggcat     1080

gtggagacag agaagactct tgggtttctg ataggcactg actctctctg cctattggtc     1140

tattttccca cccttaggct gctggtggtc tacccttgga cccagaggtt ctttgagtcc     1200

tttggggatc tgtccactcc tgatgctgtt atgggcaacc ctaaggtgaa ggctcatggc     1260

aagaaagtgc tcggtgcctt tagtgatggc ctggctcacc tggacaacct caagggcacc     1320

tttgcccagc tgagtgagct gcactgtgac aagctgcacg tggatcctga gaacttcagg     1380

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt     1440

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt     1500

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat     1560

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca     1620

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata     1680

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc     1740

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga     1800

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagctcc     1860

tgggcaacgt gctggtctgt gtgctggccc atcactttgg caaagaattc accccaccag     1920

tgcaggctgc ctatcagaaa gtggtggctg gtgtggctaa tgccctggcc cacaagtatc     1980

actaagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca     2040

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa     2100

acatttattt tcattgcaat gatgtattta aattatttct gaatatttta ctaaaaaggg     2160

aatgtgggag gttgcagtgc tagtctcccg gaactatcac tctttcacag tctgctttgg     2220

aaggactggg cttagtatga aaagttagga ctgagaagaa tttgaaaggg ggctttttgt     2280

agcttgatat tcactactgt cttattaccc tatcataggc ccaccccaaa tggaagtccc     2340

attcttcctc aggatgttta agattagcat tcaggaagag atcagaggtc tgctggctcc     2400

cttatcatgt cccttatggt gcttctggct ctgcaccgcg ggaacagaga aacaggagaa     2460

tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca     2520

gttggaacag cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc     2580

tcagggccaa gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac     2640

catcagatgt ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta     2700

accaatcagt tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tctatataag     2760

cagagctcgt ttagtgaacc gtcagatcgc ggccgcgccg ccaccatggt gagcaagggc     2820

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc     2880

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg     2940

aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg     3000

acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc     3060

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc     3120

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag     3180

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     3240

tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac     3300

ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag     3360

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag     3420

tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     3480

accgccgccg ggatcactct cggcatggac gagctgtaca agtaagcttt atttgtgaaa     3540

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca     3600

acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagcc     3660

ctgcaggatg ggtcatttca cagaggagga caaggctact atcacaagcc tgtggggcaa     3720

ggtgaatgtg gaagatgctg gaggagaaac cctgggaagg taggctctgg tgaccaggac     3780

aagggaggga aggaaggacc ctgtgcctgg caaaagtcca ggtcgcttct caggatttgt     3840

ggcaccttct gactgtcaaa ctgttcttgt caatctcaca ggctcctggt tgtctaccca     3900

tggacccaga ggttctttga cagctttggc aacctgtcct ctgcctctgc catcatgggc     3960

aaccccaaag tcaaggcaca tggcaagaag gtgctgactt ccttgggaga tgccacaaag     4020

cacctggatg atctcaaggg cacctttgcc cagctgagtg aactgcactg tgacaagctg     4080

catgtggatc ctgagaactt caaggtgagt ccaggagatg tttcagccct gttgccttta     4140

gtctcgaggc aacttagaca acggagtatt gatctgagca cagcagggtg tgagctgttt     4200

gaagatactg gggttggggg tgaagaaact gcagaggact aactgggctg agacccagtg     4260

gtaatgtgtc gacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct     4320

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4380

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca     4440

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     4500

atggcgaatg gcgattccgt tgcaatggct ggcggtaata ttgttctgga tattaccagc     4560

aaggccgata gtttgagttc ttctactcag gcaagtgatg ttattactaa tcaaagaagt     4620

attgcgacaa cggttaattt gcgtgatgga cagactcttt tactcggtgg cctcactgat     4680

tataaaaaca cttctcagga ttctggcgta ccgttcctgt ctaaaatccc tttaatcggc     4740

ctcctgttta gctcccgctc tgattctaac gaggaaagca cgttatacgt gctcgtcaaa     4800

gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4860

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4920

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4980

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     5040

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     5100

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     5160

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     5220

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttaaa tatttgctta     5280

tacaatcttc ctgtttttgg ggcttttctg attatcaacc ggggtacata tgattgacat     5340

gctagtttta cgattaccgt tcatcgattc tcttgtttgc tccagactct caggcaatga     5400

cctgatagcc tttgtagaga cctctcaaaa atagctaccc tctccggcat gaatttatca     5460

gctagaacgg ttgaatatca tattgatggt gatttgactg tctccggcct ttctcacccg     5520

tttgaatctt tacctacaca ttactcaggc attgcattta aaatatatga gggttctaaa     5580

aatttttatc cttgcgttga aataaaggct tctcccgcaa aagtattaca gggtcataat     5640

gtttttggta caaccgattt agctttatgc tctgaggctt tattgcttaa ttttgctaat     5700

tctttgcctt gcctgtatga tttattggat gttggaatcg cctgatgcgg tattttctcc     5760

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg     5820

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     5880

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     5940

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     6000

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     6060

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     6120

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     6180

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     6240

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6300

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6360

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6420

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6480

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     6540

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     6600

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6660

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6720

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6780

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6840

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6900

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6960

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     7020

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     7080

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     7140

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7200

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7260

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7320

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7380

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7440

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7500

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7560

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7620

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7680

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7740

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7800

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7860

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7920

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     7980

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatg                 8029


<210>  32
<211>  8466
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  32
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg      240

tagatctcat ctttactgag catagaagag ctacgccaaa accctgggtc atcagccagc      300

acacacactt atccagtggt aaatacacat catctggtgt atacatacat acctgaatat      360

ggaatcaaat atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa      420

gtagatattg aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg      480

aaactgtggc tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc      540

aaaagtcaca aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc      600

taactgaaag agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat      660

ttcacaatcc ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc      720

actggagcta gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta      780

tgatgggaga aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg      840

aatcggaagt aaatacactt gcaaaggagg atgtttttag tagcaatttg tactgatggt      900

atggggccaa gagatatatc ttagagggag ggctgagggt ttgaagtcca actcctaagc      960

cagtgccaga agagccaagg acaggtacgg ctgtcatcac ttagacctca ccctgtggag     1020

ccacacccta gggttggcca atctactccc aggagcaggg agggcaggag ccagggctgg     1080

gcataaaagt cagggcagag ccatctattg cttatggtgc acctgactcc tgaggagaag     1140

tctgccgtta ctgccctgtg gggcaaggtg aacgtggatg aagttggtgg tgaggccctg     1200

ggcaggctgc tggtggtcta cccttggacc cagaggttct ttgagtcctt tggggatctg     1260

tccactcctg atgctgttat gggcaaccct aaggtgaagg ctcatggcaa gaaagtgctc     1320

ggtgccttta gtgatggcct ggctcacctg gacaacctca agggcacctt tgcccagctg     1380

agtgagctgc actgtgacaa gctgcacgtg gatcctgaga acttcagggt gagtctatgg     1440

gacccttgat gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg     1500

agaagtaaca gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa     1560

aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat     1620

ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga     1680

ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg     1740

catataaatt gtaactgatg taagaggttt catattgcta atagcagcta caatccagct     1800

accattctgc ttttatttta tggttgggat aaggctggat tattctgagt ccaagctagg     1860

cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg ggcaacgtgc     1920

tggtctgtgt gctggcccat cactttggca aagaattcac cccaccagtg caggctgcct     1980

atcagaaagt ggtggctggt gtggctaatg ccctggccca caagtatcac taagctcgct     2040

ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc taagtccaac tactaaactg     2100

ggggatatta tgaagggcct tgagcatctg gattctgcct aataaaaaac atttattttc     2160

attgcaatga tgtatttaaa ttatttctga atattttact aaaaagggaa tgtgggaggt     2220

cagtgcattt aaaacataaa gaaatgaaga gctagttcaa accttgggaa aatacactat     2280

atcttaaact ccatgaaaga aggtgaggct gcaaacagct aatgcacatt ggcaacagcc     2340

cctgatgcct atgccttatt catccctcag aaaaggattc aagtagaggc ttgatttgga     2400

ggttaaagtt ttgctatgct gtattttaca ttacttattg ttttagctgt cctcatgaat     2460

gtcttttcac tacccatttg cttatcctgc atctctcagc cttgactcca ctcagttctc     2520

ttgcttagag ataccacctt tcccctgaag tgttccttcc atgttttacg gcgagatggt     2580

ttctcctcgc ctggccactc agccttagtt gtctctgttg tcttatagag gtctacttga     2640

agaaggaaaa acagggggca tggtttgact gtcctgtgag cccttcttcc ctgcctcccc     2700

cactcacagt gacccggaat ctgcagtgct agtctcccgg aactatcact ctttcacagt     2760

ctgctttgga aggactgggc ttagtatgaa aagttaggac tgagaagaat ttgaaagggg     2820

gctttttgta gcttgatatt cactactgtc ttattaccct atcataggcc caccccaaat     2880

ggaagtccca ttcttcctca ggatgtttaa gattagcatt caggaagaga tcagaggtct     2940

gctggctccc ttatcatgtc ccttatggtg cttctggctc tgcagttatt agcatagtgt     3000

taccatcaac caccttaact tcatttttct tattcaatac ctagccgcgg gaacagagaa     3060

acaggagaat atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg     3120

ccaagaacag ttggaacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc     3180

tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc tcagcagttt     3240

ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta     3300

tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct     3360

ctatataagc agagctcgtt tagtgaaccg tcagatcgcg gccgcgccgc caccatggac     3420

aaggattgtg aaatgaaacg caccacactg gacagccctt tggggaagct ggagctgtct     3480

ggttgtgagc agggtctgca cgaaataaag ctcctgggca aggggacgtc tgcagctgat     3540

gccgtggagg tcccagcccc cgctgcggtt ctcggaggtc cggagcccct gatgcagtgc     3600

acagcctggc tgaatgccta tttccaccag cccgaggcta tcgaagagtt ccccgtgccg     3660

gctcttcacc atcccgtttt ccagcaagag tcgttcacca gacaggtgtt atggaagctg     3720

ctgaaggttg tgaaattcgg agaagtgatt tcttaccagc aattagcagc cctggcaggc     3780

aaccccaaag ccgcgcgagc agtgggagga gcaatgagag gcaatcctgt caaaatcctc     3840

atcccgtgcc acagagtggt ctgcagcagc ggagccgtgg gcaactactc cggaggactg     3900

gccgtgaagg aatggcttct ggcccatgaa ggccaccggt tggggaagcc aggcttggga     3960

gggagctcag gtctggcagg ggcctggctc aagggagcgg gagctacctc gggctccccg     4020

cctgctggcc gaaacgaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat     4080

ccgggccccc ctgcaggaac ttcaaggtga gtccaggaga tgtttcagcc ctgttgcctt     4140

tagtctcgag gcaacttaga caacggagta ttgatctgag cacagcaggg tgtgagctgt     4200

ttgaagatac tggggttggg ggtgaagaaa ctgcagagga ctaactgggc tgagacccag     4260

tggtaatgtt ttagggccta aggagtgcct ctaaaaatct agatggacaa ttttgacttt     4320

gagaaaagag aggtggaaat gaggaaaatg acttttcttt attagattcc agtagaaaga     4380

actttcatct ttccctcatt tttgttgttt taaaacatct atctggaggc aggacaagta     4440

tggtcgttaa aaagatgcag gcagaaggca tatattggct cagtcaaagt ggggaacttt     4500

ggtggccaaa catacattgc taaggctatt cctatatcag ctggacacat ataaaatgct     4560

gctaatgctt cattacaaac ttatatcctt taattccaga tgggggcaaa gtatgtccag     4620

gggtgaggaa caattgaaac atttgggctg gagtagattt tgaaagtcag ctctgtgtgt     4680

gtgtgtgtgt gtgcgcgcgc gcgtgtcgac gtagataagt agcatggcgg gttaatcatt     4740

aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     4800

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     4860

agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca     4920

acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg     4980

ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta     5040

ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac     5100

tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta     5160

aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt     5220

tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg     5280

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct     5340

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat     5400

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt     5460

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg     5520

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac     5580

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta     5640

aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca     5700

atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg     5760

gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc     5820

agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct     5880

ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct     5940

ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa     6000

tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag     6060

tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat     6120

tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct     6180

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     6240

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc     6300

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     6360

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa     6420

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac     6480

gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat     6540

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg     6600

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc     6660

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga     6720

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga     6780

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg     6840

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc     6900

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac     6960

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact     7020

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca     7080

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg     7140

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact     7200

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg     7260

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg     7320

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat     7380

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc     7440

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat     7500

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt     7560

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     7620

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     7680

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     7740

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt     7800

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     7860

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     7920

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     7980

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     8040

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     8100

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     8160

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     8220

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     8280

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc     8340

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag     8400

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca     8460

ttaatg                                                                8466


<210>  33
<211>  8252
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  33
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctttttt ccttagaaac cactgctaac tgaaagagac      180

taagatttgt cccgtcaaaa atcctggacc tatgcctaaa acacatttca caatccctga      240

acttttcaaa aattggtaca tgctttagct ttaaactaca ggcctcactg gagctagaga      300

caagaaggta aaaaacggct gacaaaagaa gtcctggtat cctctatgat gggagaagga      360

aactagctaa agggaagaat aaattagaga aaaactggaa tgactgaatc ggaacaaggc      420

aaaggctata aaaaaaatta gcagtatcct cttgggggcc ccttccccac actatctcaa      480

tgcaaatatc tgtctgaaac ggtccctggc taaactccac gtaaatacac ttgcaaagga      540

ggatgttttt agtagcaatt tgtactgatg gtatggggcc aagagatata tcttagaggg      600

agggctgagg gtttgaagtc caactcctaa gccagtgcca gaagagccaa ggacaggtac      660

ggctgtcatc acttagacct caccctgtgg agccacaccc tagggttggc caatctactc      720

ccaggagcag ggagggcagg agccagggct gggcataaaa gtcagggcag agccatctat      780

tgcttacatt tgcttctgac acaactgtgt tcactagcaa cctcaaacag acaccatggt      840

gcacctgact cctgaggaga agtctgccgt tactgccctg tggggcaagg tgaacgtgga      900

tgaagttggt ggtgaggccc tgggcaggtt ggtatcaagg ttacaagaca ggtttaagga      960

gaccaataga aactgggcat gtggagacag agaagactct tgggtttctg ataggcactg     1020

actctctctg cctattggtc tattttccca cccttaggct gctggtggtc tacccttgga     1080

cccagaggtt ctttgagtcc tttggggatc tgtccactcc tgatgctgtt atgggcaacc     1140

ctaaggtgaa ggctcatggc aagaaagtgc tcggtgcctt tagtgatggc ctggctcacc     1200

tggacaacct caagggcacc tttgcccagc tgagtgagct gcactgtgac aagctgcacg     1260

tggatcctga gaacttcagg gtgagtctat gggacccttg atgttttctt tccccttctt     1320

ttctatggtt aagttcatgt cataggaagg ggagaagtaa cagggtacac atattgacca     1380

aatcagggta attttgcatt tgtaatttta aaaaatgctt tcttctttta atatactttt     1440

ttgtttatct tatttctaat actttcccta atctctttct ttcagggcaa taatgataca     1500

atgtatcatg cctctttgca ccattctaaa gaataacagt gataatttct gggttaaggc     1560

aatagcaata tttctgcata taaatatttc tgcatataaa ttgtaactga tgtaagaggt     1620

ttcatattgc taatagcagc tacaatccag ctaccattct gcttttattt tatggttggg     1680

ataaggctgg attattctga gtccaagcta ggcccttttg ctaatcatgt tcatacctct     1740

tatcttcctc ccacagctcc tgggcaacgt gctggtctgt gtgctggccc atcactttgg     1800

caaagaattc accccaccag tgcaggctgc ctatcagaaa gtggtggctg gtgtggctaa     1860

tgccctggcc cacaagtatc actaagctcg ctttcttgct gtccaatttc tattaaaggt     1920

tcctttgttc cctaagtcca actactaaac tgggggatat tatgaagggc cttgagcatc     1980

tggattctgc ctaataaaaa acatttattt tcattgcaat gatgtattta aattatttct     2040

gaatatttta ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata aagaaatgaa     2100

gagctagttc aaaccttggg aaaatacact atatcttaaa ctccatgaaa gaaggtgagg     2160

ctgcaaacag ctaatgcaca ttggcaacag cccctgatgc ctatgcctta ttcatccctc     2220

agaaaaggat tcaagtagag gcttgatttg gaggttaaag ttttgctatg ctgtatttta     2280

cattacttat tgttttagct gtcctcatga atgtcttttc actacccatt tgcttatcct     2340

gcatctctca gccttgactc cactcagttc tcttgcttag agataccacc tttcccctga     2400

agtgttcctt ccatgtttta cggcgagatg gtttctcctc gcctggccac tcagccttag     2460

ttgtctctgt tgtcttatag aggtctactt gaagaaggaa aaacaggggg catggtttga     2520

ctgtcctgtg agcccttctt ccctgcctcc cccactcaca gtgacccgga atctgcagtg     2580

ctagtctccc ggaactatca ctctttcaca gtctgctttg gaaggactgg gcttagtatg     2640

aaaagttagg actgagaaga atttgaaagg gggctttttg tagcttgata ttcactactg     2700

tcttattacc ctatcatagg cccaccccaa atggaagtcc cattcttcct caggatgttt     2760

aagattagca ttcaggaaga gatcagaggt ctgctggctc ccttatcatg tcccttatgg     2820

tgcttctggc tctgcagtta ttagcatagt gttaccatca accaccttaa cttcattttt     2880

cttattcaat acctagccgc gggaacagag aaacaggaga atatgggcca aacaggatat     2940

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agttggaaca gcagaatatg     3000

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg     3060

gtccccagat gcggtcccgc cctcagcagt ttctagagaa ccatcagatg tttccagggt     3120

gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag ttcgcttctc     3180

gcttctgttc gcgcgcttct gctccccgag ctctatataa gcagagctcg tttagtgaac     3240

cgtcagatcg cggccgcgcc gccaccatgg tgagcaaggg cgaggagctg ttcaccgggg     3300

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg     3360

gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg     3420

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct     3480

tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag     3540

gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg     3600

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca     3660

aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct     3720

atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca     3780

tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg     3840

gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc     3900

ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc     3960

tcggcatgga cgagctgtac aagtaagctt tatttgtgaa atttgtgatg ctattgcttt     4020

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     4080

gtttcaggtt cagggggaga tgtgggaggt tttttaaagc cctgcaggat gggtcatttc     4140

acagaggagg acaaggctac tatcacaagc ctgtggggca aggtgaatgt ggaagatgct     4200

ggaggagaaa ccctgggaag gtaggctctg gtgaccagga caagggaggg aaggaaggac     4260

cctgtgcctg gcaaaagtcc aggtcgcttc tcaggatttg tggcaccttc tgactgtcaa     4320

actgttcttg tcaatctcac aggctcctgg ttgtctaccc atggacccag aggttctttg     4380

acagctttgg caacctgtcc tctgcctctg ccatcatggg caaccccaaa gtcaaggcac     4440

atggcaagaa ggtgctgact tccttgggag atgccacaaa gcacctggat gatctcaagg     4500

gcacctttgc ccagctgagt gaactgcagt cgacaggaac ccctagtgat ggagttggcc     4560

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4620

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctggcg taatagcgaa     4680

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgattc     4740

cgttgcaatg gctggcggta atattgttct ggatattacc agcaaggccg atagtttgag     4800

ttcttctact caggcaagtg atgttattac taatcaaaga agtattgcga caacggttaa     4860

tttgcgtgat ggacagactc ttttactcgg tggcctcact gattataaaa acacttctca     4920

ggattctggc gtaccgttcc tgtctaaaat ccctttaatc ggcctcctgt ttagctcccg     4980

ctctgattct aacgaggaaa gcacgttata cgtgctcgtc aaagcaacca tagtacgcgc     5040

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     5100

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     5160

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     5220

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     5280

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     5340

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     5400

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     5460

attttaacaa aatattaacg tttacaattt aaatatttgc ttatacaatc ttcctgtttt     5520

tggggctttt ctgattatca accggggtac atatgattga catgctagtt ttacgattac     5580

cgttcatcga ttctcttgtt tgctccagac tctcaggcaa tgacctgata gcctttgtag     5640

agacctctca aaaatagcta ccctctccgg catgaattta tcagctagaa cggttgaata     5700

tcatattgat ggtgatttga ctgtctccgg cctttctcac ccgtttgaat ctttacctac     5760

acattactca ggcattgcat ttaaaatata tgagggttct aaaaattttt atccttgcgt     5820

tgaaataaag gcttctcccg caaaagtatt acagggtcat aatgtttttg gtacaaccga     5880

tttagcttta tgctctgagg ctttattgct taattttgct aattctttgc cttgcctgta     5940

tgatttattg gatgttggaa tcgcctgatg cggtattttc tccttacgca tctgtgcggt     6000

atttcacacc gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     6060

cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca     6120

tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg     6180

tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat     6240

gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga     6300

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     6360

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt     6420

gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg     6480

ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg     6540

gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg     6600

agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag     6660

caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca     6720

gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg     6780

agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc     6840

gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg     6900

aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg     6960

ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac     7020

tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg     7080

tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg     7140

gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact     7200

atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa     7260

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     7320

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     7380

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     7440

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     7500

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     7560

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     7620

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     7680

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     7740

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     7800

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     7860

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     7920

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     7980

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     8040

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     8100

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     8160

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg     8220

cctctccccg cgcgttggcc gattcattaa tg                                   8252


<210>  34
<211>  7375
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  34
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttttttcct tagaaaccac tgctaactga aagagactaa gatttgtccc gtcaaaaatc      240

ctggacctat gcctaaaaca catttcacaa tccctgaact tttcaaaaat tggtacatgc      300

tttagcttta aactacaggc ctcactggag ctagagacaa gaaggtaaaa aacggctgac      360

aaaagaagtc ctggtatcct ctatgatggg agaaggaaac tagctaaagg gaagaataaa      420

ttagagaaaa actggaatga ctgaatcgga acaaggcaaa ggctataaaa aaaattagca      480

gtatcctctt gggggcccct tccccacact atctcaatgc aaatatctgt ctgaaacggt      540

ccctggctaa actccaccca tgggttggcc agccttgcct tgacaaggca aacttgacca      600

atagtcttag agtatccagt gaggccaggg gccggcggct ggctagggat gaagaataaa      660

aggaagcacc cttcagcagt tccacacact cgcttctgga acgtctgagg ttatcaataa      720

gctcctagtc cagacgccgc cgccaccatg gtccatctta caccggagga gaagtccgct      780

gtaacggcac tgtgggggaa agttaatgtc gatgaagtcg gcggtgaagc actcggcagg      840

ttgctggtag tgtacccgtg gacacaacga ttctttgaaa gtttcgggga cctgtccaca      900

cccgatgctg tgatgggtaa tccaaaagta aaagcacacg gcaagaaagt cctcggcgcg      960

tttagtgatg gtctggccca tttggataac ttgaagggta cattcgcgca gctttccgaa     1020

ctccactgtg acaagttgca cgtagatcca gaaaacttcc ggcttctggg caatgtgctt     1080

gtatgcgttc tggctcacca ttttgggaag gagtttaccc cacccgtgca agcggcttac     1140

caaaaagtgg tcgcaggagt ggctaatgcc cttgcacata aatatcacta aggtaccgag     1200

catcttaccg ccatttattc ccatatttgt tctgtttttc ttgatttggg tatacattta     1260

aatgttaata aaacaaaatg gtggggcaat catttacatt tttagggata tgtaattact     1320

agttcaggtg tattgccaca agacaaacat gttaagaaac tttcccgtta tttacgctct     1380

gttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactga tattcttaac     1440

tatgttgctc cttttacgct gtgtggatat gctgctttat agcctctgta tctagctatt     1500

gcttcccgta cggctttcgt tttctcctcc ttgtataaat cctggttgct gtctctttta     1560

gaggagttgt ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt tgctgacgca     1620

acccccactg gctggggcat tgccaccacc tgtcaactcc tttctgggac tttcgctttc     1680

cccctcccga tcgccacggc agaactcatc gccgcctgcc ttgcccgctg ctggacaggg     1740

gctaggttgc tgggcactga taattccgtg gtgttgtctg tgccttctag ttgccagcca     1800

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     1860

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     1920

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     1980

ggggatgcgg tgggctctat ggcccgcggg aacagagaaa caggagaata tgggccaaac     2040

aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacagt tggaacagca     2100

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga     2160

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt     2220

ccagggtgcc ccaaggacct gaaatgaccc tgtgccttat ttgaactaac caatcagttc     2280

gcttctcgct tctgttcgcg cgcttctgct ccccgagctc tatataagca gagctcgttt     2340

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacttcc atagaaggcg     2400

gccgcgccgc caccatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc     2460

tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg     2520

gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg     2580

tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc     2640

ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg     2700

agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg     2760

agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca     2820

acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg     2880

acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca     2940

gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc     3000

tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc     3060

gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg     3120

agctgtacaa gggaagcgga gctactaact tcagcctgct gaagcaggct ggagacgtgg     3180

aggagaaccc tggacctcct gcaggaactt caaggtgagt ccaggagatg tttcagccct     3240

gttgccttta gtctcgaggc aacttagaca acggagtatt gatctgagca cagcagggtg     3300

tgagctgttt gaagatactg gggttggggg tgaagaaact gcagaggact aactgggctg     3360

agacccagtg gtaatgtttt agggcctaag gagtgcctct aaaaatctag atggacaatt     3420

ttgactttga gaaaagagag gtggaaatga ggaaaatgac ttttctttat tagattccag     3480

tagaaagaac tttcatcttt ccctcatttt tgttgtttta aaacatctat ctggaggcag     3540

gacaagtatg gtcgttaaaa agatgcaggc agaaggcata tattggctca gtcaaagtgg     3600

ggaactttgg tgggtcgacg tagataagta gcatggcggg ttaatcatta actacaagga     3660

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     3720

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     3780

gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca     3840

gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt tctggatatt     3900

accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat tactaatcaa     3960

agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact cggtggcctc     4020

actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa aatcccttta     4080

atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt atacgtgctc     4140

gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     4200

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     4260

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     4320

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     4380

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     4440

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     4500

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     4560

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa tttaaatatt     4620

tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg tacatatgat     4680

tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca gactctcagg     4740

caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc cggcatgaat     4800

ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc cggcctttct     4860

cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat atatgagggt     4920

tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt attacagggt     4980

cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt gcttaatttt     5040

gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg atgcggtatt     5100

ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct     5160

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     5220

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     5280

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     5340

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     5400

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     5460

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     5520

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     5580

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     5640

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     5700

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     5760

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     5820

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     5880

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     5940

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     6000

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     6060

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     6120

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     6180

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     6240

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     6300

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     6360

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     6420

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     6480

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     6540

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     6600

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     6660

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     6720

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     6780

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     6840

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     6900

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     6960

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     7020

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     7080

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     7140

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     7200

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     7260

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     7320

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatg          7375


<210>  35
<211>  8089
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  35
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttttttcct tagaaaccac tgctaactga aagagactaa gatttgtccc gtcaaaaatc      240

ctggacctat gcctaaaaca catttcacaa tccctgaact tttcaaaaat tggtacatgc      300

tttagcttta aactacaggc ctcactggag ctagagacaa gaaggtaaaa aacggctgac      360

aaaagaagtc ctggtatcct ctatgatggg agaaggaaac tagctaaagg gaagaataaa      420

ttagagaaaa actggaatga ctgaatcgga acaaggcaaa ggctataaaa aaaattagca      480

gtatcctctt gggggcccct tccccacact atctcaatgc aaatatctgt ctgaaacggt      540

ccctggctaa actccaccca tgggttggcc agccttgcct tgacaaggca aacttgacca      600

atagtcttag agtatccagt gaggccaggg gccggcggct ggctagggat gaagaataaa      660

aggaagcacc cttcagcagt tccacacact cgcttctgga acgtctgagg ttatcaataa      720

gctcctagtc cagacgccgc cgccaccatg gtccatctta caccggagga gaagtccgct      780

gtaacggcac tgtgggggaa agttaatgtc gatgaagtcg gcggtgaagc actcggcagg      840

ttgctggtag tgtacccgtg gacacaacga ttctttgaaa gtttcgggga cctgtccaca      900

cccgatgctg tgatgggtaa tccaaaagta aaagcacacg gcaagaaagt cctcggcgcg      960

tttagtgatg gtctggccca tttggataac ttgaagggta cattcgcgca gctttccgaa     1020

ctccactgtg acaagttgca cgtagatcca gaaaacttcc ggcttctggg caatgtgctt     1080

gtatgcgttc tggctcacca ttttgggaag gagtttaccc cacccgtgca agcggcttac     1140

caaaaagtgg tcgcaggagt ggctaatgcc cttgcacata aatatcacta aggtaccgag     1200

catcttaccg ccatttattc ccatatttgt tctgtttttc ttgatttggg tatacattta     1260

aatgttaata aaacaaaatg gtggggcaat catttacatt tttagggata tgtaattact     1320

agttcaggtg tattgccaca agacaaacat gttaagaaac tttcccgtta tttacgctct     1380

gttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactga tattcttaac     1440

tatgttgctc cttttacgct gtgtggatat gctgctttat agcctctgta tctagctatt     1500

gcttcccgta cggctttcgt tttctcctcc ttgtataaat cctggttgct gtctctttta     1560

gaggagttgt ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt tgctgacgca     1620

acccccactg gctggggcat tgccaccacc tgtcaactcc tttctgggac tttcgctttc     1680

cccctcccga tcgccacggc agaactcatc gccgcctgcc ttgcccgctg ctggacaggg     1740

gctaggttgc tgggcactga taattccgtg gtgttgtctg tgccttctag ttgccagcca     1800

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     1860

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     1920

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     1980

ggggatgcgg tgggctctat ggccgagatc gagaccatcc tggctaacac agtgaaaccc     2040

cgtctctact aaaaaaatac aaaaaattag ccgggcttgg tggcgggtgc ctgtagtccc     2100

agctactatg gaggctgagg cgggagaatg gcgtgaacgc ggggggcgga gcttgcagtg     2160

agcagagatc aggggccact gcactccagc ctgggcgaca gagagagact ctgtctcaaa     2220

aaaaagaaaa aaaaaattta gtagactagc taaaaaaatc cagagatagt tattgatgca     2280

tatgtaaaag tcttccaata tttacaagta caatgaaaaa aaaataacct tgaattaagt     2340

gtagaactca ttgacaatgt ttcaaaggat gtgagggata aactaaaatt tgggcagtac     2400

atgctgttcc tgtgtacttg gaacagaggg agaaaatctg ggctggaaat attgttatag     2460

gagttagcac atgaaggtga caactaaatt atttggagta gatggagtca ccagcacatg     2520

tgaatagttt tagaatgaaa tgacccaaga tagaactttg gagagccccc aaatttaaat     2580

aaaatcagta taagagaaga ggaagaaacc aaatggtata ctagtctaaa ttgtttctta     2640

gtgacaaaag aataacctga atattagatt agctgcctat atgctctctg aatcaatttc     2700

attcaacatg caacagtccg cgggaacaga gaaacaggag aatatgggcc aaacaggata     2760

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagttggaac agcagaatat     2820

gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat     2880

ggtccccaga tgcggtcccg ccctcagcag tttctagaga accatcagat gtttccaggg     2940

tgccccaagg acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct     3000

cgcttctgtt cgcgcgcttc tgctccccga gctctatata agcagagctc gtttagtgaa     3060

ccgtcagatc gcctggagac gccatccacg ctgttttgac ttccatagaa ggcggccgcg     3120

ccgccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg     3180

agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg     3240

ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct     3300

ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc     3360

acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca     3420

ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg     3480

acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc     3540

tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc     3600

agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc     3660

agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg     3720

acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc     3780

acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt     3840

acaagggaag cggagctact aacttcagcc tgctgaagca ggctggagac gtggaggaga     3900

accctggacc tcctgcagga acttcaaggt gagtccagga gatgtttcag ccctgttgcc     3960

tttagtctcg aggcaactta gacaacggag tattgatctg agcacagcag ggtgtgagct     4020

gtttgaagat actggggttg ggggtgaaga aactgcagag gactaactgg gctgagaccc     4080

agtggtaatg ttttagggcc taaggagtgc ctctaaaaat ctagatggac aattttgact     4140

ttgagaaaag agaggtggaa atgaggaaaa tgacttttct ttattagatt ccagtagaaa     4200

gaactttcat ctttccctca tttttgttgt tttaaaacat ctatctggag gcaggacaag     4260

tatggtcgtt aaaaagatgc aggcagaagg catatattgg ctcagtcaaa gtggggaact     4320

ttggtgggtc gacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct     4380

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4440

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca     4500

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     4560

atggcgaatg gcgattccgt tgcaatggct ggcggtaata ttgttctgga tattaccagc     4620

aaggccgata gtttgagttc ttctactcag gcaagtgatg ttattactaa tcaaagaagt     4680

attgcgacaa cggttaattt gcgtgatgga cagactcttt tactcggtgg cctcactgat     4740

tataaaaaca cttctcagga ttctggcgta ccgttcctgt ctaaaatccc tttaatcggc     4800

ctcctgttta gctcccgctc tgattctaac gaggaaagca cgttatacgt gctcgtcaaa     4860

gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4920

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4980

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     5040

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     5100

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     5160

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     5220

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     5280

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttaaa tatttgctta     5340

tacaatcttc ctgtttttgg ggcttttctg attatcaacc ggggtacata tgattgacat     5400

gctagtttta cgattaccgt tcatcgattc tcttgtttgc tccagactct caggcaatga     5460

cctgatagcc tttgtagaga cctctcaaaa atagctaccc tctccggcat gaatttatca     5520

gctagaacgg ttgaatatca tattgatggt gatttgactg tctccggcct ttctcacccg     5580

tttgaatctt tacctacaca ttactcaggc attgcattta aaatatatga gggttctaaa     5640

aatttttatc cttgcgttga aataaaggct tctcccgcaa aagtattaca gggtcataat     5700

gtttttggta caaccgattt agctttatgc tctgaggctt tattgcttaa ttttgctaat     5760

tctttgcctt gcctgtatga tttattggat gttggaatcg cctgatgcgg tattttctcc     5820

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg     5880

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     5940

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     6000

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     6060

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     6120

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     6180

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     6240

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     6300

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6360

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6420

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6480

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6540

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     6600

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     6660

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6720

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6780

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6840

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6900

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6960

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     7020

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     7080

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     7140

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     7200

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7260

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7320

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7380

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7440

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7500

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7560

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7620

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7680

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7740

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7800

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7860

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7920

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7980

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     8040

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatg                 8089


<210>  36
<211>  8152
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  36
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttttttcct tagaaaccac tgctaactga aagagactaa gatttgtccc gtcaaaaatc      240

ctggacctat gcctaaaaca catttcacaa tccctgaact tttcaaaaat tggtacatgc      300

tttagcttta aactacaggc ctcactggag ctagagacaa gaaggtaaaa aacggctgac      360

aaaagaagtc ctggtatcct ctatgatggg agaaggaaac tagctaaagg gaagaataaa      420

ttagagaaaa actggaatga ctgaatcgga acaaggcaaa ggctataaaa aaaattagca      480

gtatcctctt gggggcccct tccccacact atctcaatgc aaatatctgt ctgaaacggt      540

ccctggctaa actccaccca tgggttggcc agccttgcct tgacaaggca aacttgacca      600

atagtcttag agtatccagt gaggccaggg gccggcggct ggctagggat gaagaataaa      660

aggaagcacc cttcagcagt tccacacact cgcttctgga acgtctgagg ttatcaataa      720

gctcctagtc cagacgccgc cgccaccatg gtccatctta caccggagga gaagtccgct      780

gtaacggcac tgtgggggaa agttaatgtc gatgaagtcg gcggtgaagc actcggcagg      840

ttgctggtag tgtacccgtg gacacaacga ttctttgaaa gtttcgggga cctgtccaca      900

cccgatgctg tgatgggtaa tccaaaagta aaagcacacg gcaagaaagt cctcggcgcg      960

tttagtgatg gtctggccca tttggataac ttgaagggta cattcgcgca gctttccgaa     1020

ctccactgtg acaagttgca cgtagatcca gaaaacttcc ggcttctggg caatgtgctt     1080

gtatgcgttc tggctcacca ttttgggaag gagtttaccc cacccgtgca agcggcttac     1140

caaaaagtgg tcgcaggagt ggctaatgcc cttgcacata aatatcacta aggtaccgag     1200

catcttaccg ccatttattc ccatatttgt tctgtttttc ttgatttggg tatacattta     1260

aatgttaata aaacaaaatg gtggggcaat catttacatt tttagggata tgtaattact     1320

agttcaggtg tattgccaca agacaaacat gttaagaaac tttcccgtta tttacgctct     1380

gttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactga tattcttaac     1440

tatgttgctc cttttacgct gtgtggatat gctgctttat agcctctgta tctagctatt     1500

gcttcccgta cggctttcgt tttctcctcc ttgtataaat cctggttgct gtctctttta     1560

gaggagttgt ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt tgctgacgca     1620

acccccactg gctggggcat tgccaccacc tgtcaactcc tttctgggac tttcgctttc     1680

cccctcccga tcgccacggc agaactcatc gccgcctgcc ttgcccgctg ctggacaggg     1740

gctaggttgc tgggcactga taattccgtg gtgttgtctg tgccttctag ttgccagcca     1800

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     1860

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     1920

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct     1980

ggggatgcgg tgggctctat ggccgagatc gagaccatcc tggctaacac agtgaaaccc     2040

cgtctctact aaaaaaatac aaaaaattag ccgggcttgg tggcgggtgc ctgtagtccc     2100

agctactatg gaggctgagg cgggagaatg gcgtgaacgc ggggggcgga gcttgcagtg     2160

agcagagatc aggggccact gcactccagc ctgggcgaca gagagagact ctgtctcaaa     2220

aaaaagaaaa aaaaaattta gtagactagc taaaaaaatc cagagatagt tattgatgca     2280

tatgtaaaag tcttccaata tttacaagta caatgaaaaa aaaataacct tgaattaagt     2340

gtagaactca ttgacaatgt ttcaaaggat gtgagggata aactaaaatt tgggcagtac     2400

atgctgttcc tgtgtacttg gaacagaggg agaaaatctg ggctggaaat attgttatag     2460

gagttagcac atgaaggtga caactaaatt atttggagta gatggagtca ccagcacatg     2520

tgaatagttt tagaatgaaa tgacccaaga tagaactttg gagagccccc aaatttaaat     2580

aaaatcagta taagagaaga ggaagaaacc aaatggtata ctagtctaaa ttgtttctta     2640

gtgacaaaag aataacctga atattagatt agctgcctat atgctctctg aatcaatttc     2700

attcaacatg caacagtccg cgggaacaga gaaacaggag aatatgggcc aaacaggata     2760

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagttggaac agcagaatat     2820

gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat     2880

ggtccccaga tgcggtcccg ccctcagcag tttctagaga accatcagat gtttccaggg     2940

tgccccaagg acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct     3000

cgcttctgtt cgcgcgcttc tgctccccga gctctatata agcagagctc gtttagtgaa     3060

ccgtcagatc gcctggagac gccatccacg ctgttttgac ttccatagaa ggcggccgcg     3120

ccgccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg     3180

agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg     3240

ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct     3300

ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc     3360

acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca     3420

ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg     3480

acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc     3540

tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc     3600

agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc     3660

agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg     3720

acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc     3780

acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt     3840

acaagtaagc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag     3900

ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga     3960

gatgtgggag gttttttaaa gccctgcagg atgggtcatt tcacagagga ggacaaggct     4020

actatcacaa gcctgtgggg caaggtgaat gtggaagatg ctggaggaga aaccctggga     4080

aggtaggctc tggtgaccag gacaagggag ggaaggaagg accctgtgcc tggcaaaagt     4140

ccaggtcgct tctcaggatt tgtggcacct tctgactgtc aaactgttct tgtcaatctc     4200

acaggctcct ggttgtctac ccatggaccc agaggttctt tgacagcttt ggcaacctgt     4260

cctctgcctc tgccatcatg ggcaacccca aagtcaaggc acatggcaag aaggtgctga     4320

cttccttggg agatgccaca aagcacctgg atgatctcaa gggcaccttt gcccagctga     4380

gtgaactgca gtcgacgtag ataagtagca tggcgggtta atcattaact acaaggaacc     4440

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     4500

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     4560

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     4620

tgaatggcga atggcgattc cgttgcaatg gctggcggta atattgttct ggatattacc     4680

agcaaggccg atagtttgag ttcttctact caggcaagtg atgttattac taatcaaaga     4740

agtattgcga caacggttaa tttgcgtgat ggacagactc ttttactcgg tggcctcact     4800

gattataaaa acacttctca ggattctggc gtaccgttcc tgtctaaaat ccctttaatc     4860

ggcctcctgt ttagctcccg ctctgattct aacgaggaaa gcacgttata cgtgctcgtc     4920

aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     4980

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     5040

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     5100

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     5160

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     5220

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     5280

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     5340

ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt aaatatttgc     5400

ttatacaatc ttcctgtttt tggggctttt ctgattatca accggggtac atatgattga     5460

catgctagtt ttacgattac cgttcatcga ttctcttgtt tgctccagac tctcaggcaa     5520

tgacctgata gcctttgtag agacctctca aaaatagcta ccctctccgg catgaattta     5580

tcagctagaa cggttgaata tcatattgat ggtgatttga ctgtctccgg cctttctcac     5640

ccgtttgaat ctttacctac acattactca ggcattgcat ttaaaatata tgagggttct     5700

aaaaattttt atccttgcgt tgaaataaag gcttctcccg caaaagtatt acagggtcat     5760

aatgtttttg gtacaaccga tttagcttta tgctctgagg ctttattgct taattttgct     5820

aattctttgc cttgcctgta tgatttattg gatgttggaa tcgcctgatg cggtattttc     5880

tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct     5940

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     6000

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     6060

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     6120

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     6180

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     6240

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     6300

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     6360

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac     6420

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg     6480

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc     6540

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg     6600

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat     6660

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg     6720

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg     6780

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc     6840

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt     6900

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct     6960

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc     7020

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca     7080

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct     7140

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     7200

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     7260

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     7320

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     7380

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     7440

taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag     7500

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     7560

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     7620

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     7680

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     7740

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     7800

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     7860

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     7920

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     7980

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     8040

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     8100

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tg             8152


<210>  37
<211>  8236
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  37
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatcttaccc tgttaatggt ccaatatgtc agaaacagca      180

ctgtgttaga aataaagctg tctaaagtac actaatattc gagttataat agtgtgtgga      240

ctattagtca ataaaaacaa cccttgcctc tttagagttg ttttccatgt acacgcacat      300

cttatgtctt agagtaagat tccctgagaa gtgaacctag catttataca agataattaa      360

ttctaatcca cagtacctgc caaagaacat tctaccatca tctttactga gcatagaaga      420

gctacgccaa aaccctgggt catcagccag cacacacact tatccagtgg taaatacaca      480

tcatctggtg tatacataca tacctgaata tggaatcaaa tatttttcta agatgaaaca      540

gtcatgattt atttcaaata ggtacggata agtagatatt gaggtaagca ttaggtctta      600

tattatgtaa cactaatcta ttactgcgct gaaactgtgg ctttatagaa attgttttca      660

ctgcactatt gagaaattaa gagataatgg caaaagtcac aaagagtata ttcaaaaaga      720

agtatagcac tttttcctta gaaaccactg ctaactgaaa gagactaaga tttgtcccgt      780

caaaaatcct ggacctatgc ctaaaacaca tttcacaatc cctgaacttt tcaaaaattg      840

gtacatgctt tagctttaaa ctacaggcct cactggagct agagacaaga aggtaaaaaa      900

cggctgacaa aagaagtcct ggtatcctct atgatgggag aaggaaacta gctaaaggga      960

agaataaatt agagaaaaac tggaatgact gaatcggaac aaggcaaagg ctataaaaaa     1020

aattagcagt atcctcttgg gggccccttc cccacactat ctcaatgcaa atatctgtct     1080

gaaacggtcc ctggctaaac tccacccatg ggttggccag ccttgccttg accaatagcc     1140

ttgacgaatt cgctttaaaa aacctcccac atctccccct gaacctgaaa cataaaatga     1200

atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata     1260

gcatcacaaa tttcacaaat aaagcttact tgtacagctc gtccatgccg agagtgatcc     1320

cggcggcggt cacgaactcc agcaggacca tgtgatcgcg cttctcgttg gggtctttgc     1380

tcagggcgga ctgggtgctc aggtagtggt tgtcgggcag cagcacgggg ccgtcgccga     1440

tgggggtgtt ctgctggtag tggtcggcga gctgcacgct gccgtcctcg atgttgtggc     1500

ggatcttgaa gttcaccttg atgccgttct tctgcttgtc ggccatgata tagacgttgt     1560

ggctgttgta gttgtactcc agcttgtgcc ccaggatgtt gccgtcctcc ttgaagtcga     1620

tgcccttcag ctcgatgcgg ttcaccaggg tgtcgccctc gaacttcacc tcggcgcggg     1680

tcttgtagtt gccgtcgtcc ttgaagaaga tggtgcgctc ctggacgtag ccttcgggca     1740

tggcggactt gaagaagtcg tgctgcttca tgtggtcggg gtagcggctg aagcactgca     1800

cgccgtaggt cagggtggtc acgagggtgg gccagggcac gggcagcttg ccggtggtgc     1860

agatgaactt cagggtcagc ttgccgtagg tggcatcgcc ctcgccctcg ccggacacgc     1920

tgaacttgtg gccgtttacg tcgccgtcca gctcgaccag gatgggcacc accccggtga     1980

acagctcctc gcccttgctc accatggtgg cggcgcggcc gcgatctgac ggttcactaa     2040

acgagctctg cttatataga gctcggggag cagaagcgcg cgaacagaag cgagaagcga     2100

actgattggt tagttcaaat aaggcacagg gtcatttcag gtccttgggg caccctggaa     2160

acatctgatg gttctctaga aactgctgag ggcgggaccg catctgggga ccatctgttc     2220

ttggccctga gccggggcag gaactgctta ccacagatat cctgtttggc ccatattctg     2280

ctgttccaac tgttcttggc cctgagccgg ggcaggaact gcttaccaca gatatcctgt     2340

ttggcccata ttctcctgtt tctctgttcc cgcggcgaga tcgagaccat cctggctaac     2400

acagtgaaac cccgtctcta ctaaaaaaat acaaaaaatt agccgggctt ggtggcgggt     2460

gcctgtagtc ccagctacta tggaggctga ggcgggagaa tggcgtgaac gcggggggcg     2520

gagcttgcag tgagcagaga tcaggggcca ctgcactcca gcctgggcga cagagagaga     2580

ctctgtctca aaaaaaagaa aaaaaaaatt tagtagacta gctaaaaaaa tccagagata     2640

gttattgatg catatgtaaa agtcttccaa tatttacaag tacaatgaaa aaaaaataac     2700

cttgaattaa gtgtagaact cattgacaat gtttcaaagg atgtgaggga taaactaaaa     2760

tttgggcagt acatgctgtt cctgtgtact tggaacagag ggagaaaatc tgggctggaa     2820

atattgttat aggagttagc acatgaaggt gacaactaaa ttatttggag tagatggagt     2880

caccagcaca tgtgaatagt tttagaatga aatgacccaa gatagaactt tggagagccc     2940

ccaaatttaa ataaaatcag tataagagaa gaggaagaaa ccaaatggta tactagtcta     3000

aattgtttct tagtgacaaa agaataacct gaatattaga ttagctgcct atatgctctc     3060

tgaatcaatt tcattcaaca tgcaacagtt ctggaaccta tcagggacca cagtcagcca     3120

ggcaagcaca tctgcccaag ccaagggtgg aggcatgcag ctgtgggggt ctgtgaaaac     3180

acttgaggga gcagataact gggccaacca tgactcagtg cttctggagg ccaacaggac     3240

tgctgagtca tcctgtgggg gtggaggtgg gacaagggaa aggggtgaat ggtactgctg     3300

attacaacct ctggtgctgc ctccccctcc tgtttatctg agagaggcct cactggagct     3360

agagacaaga aggtaaaaaa cggctgacaa aagaagtcct ggtatcctct atgatgggag     3420

aaggaaacta gctaaaggga agaataaatt agagaaaaac tggaatgact gaatcggaac     3480

aaggcaaagg ctataaaaaa aattagcagt atcctcttgg gggccccttc cccacactat     3540

ctcaatgcaa atatctgtct gaaacggtcc ctggctaaac tccacccatg ggttggccag     3600

ccttgccttg acaaggcaaa cttgaccaat agtcttagag tatccagtga ggccaggggc     3660

cggcggctgg ctagggatga agaataaaag gaagcaccct tcagcagttc cacacactcg     3720

cttctggaac gtctgaggtt atcaataagc tcctagtcca gacgccatgg gtcatttcac     3780

agaggaggac aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg     3840

aggagaaacc ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc     3900

tgtgcctggc aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac     3960

tgttcttgtc aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac     4020

agctttggca acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat     4080

ggcaagaagg tgctgacttc cttgggagat gccacaaagc acctggatga tctcaagggc     4140

acctttgccc agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc     4200

aaggtgagtc caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa     4260

cggagtattg atctgagcac agcagggtgt gagctgtttg aagatactgg ggttgggggt     4320

gaagaaactg cagaggacta actgggctga gacccagtgg taatgtttta gggcctaagg     4380

agtgcctcta aaaatctaga tggacaattt tgactttgag aaaagagagg tggaaatgag     4440

gaaaatgact tttctttatt agattccagt agaaagaact ttcatctttc cctcattttt     4500

gttgttttaa aagtcgacag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4560

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4620

cggcctcagt gagcgagcga gcgcgcagct ggcgtaatag cgaagaggcc cgcaccgatc     4680

gcccttccca acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc     4740

ggtaatattg ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca     4800

agtgatgtta ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag     4860

actcttttac tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg     4920

ttcctgtcta aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag     4980

gaaagcacgt tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt     5040

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     5100

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     5160

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     5220

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     5280

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     5340

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     5400

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     5460

aacgtttaca atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt     5520

atcaaccggg gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct     5580

tgtttgctcc agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata     5640

gctaccctct ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat     5700

ttgactgtct ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt     5760

gcatttaaaa tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct     5820

cccgcaaaag tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct     5880

gaggctttat tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt     5940

ggaatcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat     6000

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc     6060

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     6120

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     6180

cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg     6240

tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     6300

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     6360

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     6420

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     6480

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     6540

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     6600

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     6660

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     6720

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     6780

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     6840

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     6900

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     6960

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     7020

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     7080

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     7140

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     7200

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     7260

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     7320

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     7380

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     7440

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     7500

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     7560

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     7620

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     7680

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     7740

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     7800

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     7860

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     7920

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     7980

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     8040

tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc     8100

gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg     8160

agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt     8220

ggccgattca ttaatg                                                     8236


<210>  38
<211>  7955
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  38
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatcttaccc tgttaatggt ccaatatgtc agaaacagca      180

ctgtgttaga aataaagctg tctaaagtac actaatattc gagttataat agtgtgtgga      240

ctattagtca ataaaaacaa cccttgcctc tttagagttg ttttccatgt acacgcacat      300

cttatgtctt agagtaagat tccctgagaa gtgaacctag catttataca agataattaa      360

ttctaatcca cagtacctgc caaagaacat tctaccatca tctttactga gcatagaaga      420

gctacgccaa aaccctgggt catcagccag cacacacact tatccagtgg taaatacaca      480

tcatctggtg tatacataca tacctgaata tggaatcaaa tatttttcta agatgaaaca      540

gtcatgattt atttcaaata ggtacggata agtagatatt gaggtaagca ttaggtctta      600

tattatgtaa cactaatcta ttactgcgct gaaactgtgg ctttatagaa attgttttca      660

ctgcactatt gagaaattaa gagataatgg caaaagtcac aaagagtata ttcaaaaaga      720

agtatagcac tttttcctta gaaaccactg ctaactgaaa gagactaaga tttgtcccgt      780

caaaaatcct ggacctatgc ctaaaacaca tttcacaatc cctgaacttt tcaaaaattg      840

gtacatgctt tagctttaaa ctacgaattc gctttaaaaa acctcccaca tctccccctg      900

aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat      960

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcttactt gtacagctcg     1020

tccatgccga gagtgatccc ggcggcggtc acgaactcca gcaggaccat gtgatcgcgc     1080

ttctcgttgg ggtctttgct cagggcggac tgggtgctca ggtagtggtt gtcgggcagc     1140

agcacggggc cgtcgccgat gggggtgttc tgctggtagt ggtcggcgag ctgcacgctg     1200

ccgtcctcga tgttgtggcg gatcttgaag ttcaccttga tgccgttctt ctgcttgtcg     1260

gccatgatat agacgttgtg gctgttgtag ttgtactcca gcttgtgccc caggatgttg     1320

ccgtcctcct tgaagtcgat gcccttcagc tcgatgcggt tcaccagggt gtcgccctcg     1380

aacttcacct cggcgcgggt cttgtagttg ccgtcgtcct tgaagaagat ggtgcgctcc     1440

tggacgtagc cttcgggcat ggcggacttg aagaagtcgt gctgcttcat gtggtcgggg     1500

tagcggctga agcactgcac gccgtaggtc agggtggtca cgagggtggg ccagggcacg     1560

ggcagcttgc cggtggtgca gatgaacttc agggtcagct tgccgtaggt ggcatcgccc     1620

tcgccctcgc cggacacgct gaacttgtgg ccgtttacgt cgccgtccag ctcgaccagg     1680

atgggcacca ccccggtgaa cagctcctcg cccttgctca ccatggtggc ggcgcggccg     1740

cgatctgacg gttcactaaa cgagctctgc ttatatagag ctcggggagc agaagcgcgc     1800

gaacagaagc gagaagcgaa ctgattggtt agttcaaata aggcacaggg tcatttcagg     1860

tccttggggc accctggaaa catctgatgg ttctctagaa actgctgagg gcgggaccgc     1920

atctggggac catctgttct tggccctgag ccggggcagg aactgcttac cacagatatc     1980

ctgtttggcc catattctgc tgttccaact gttcttggcc ctgagccggg gcaggaactg     2040

cttaccacag atatcctgtt tggcccatat tctcctgttt ctctgttccc gcggcgagat     2100

cgagaccatc ctggctaaca cagtgaaacc ccgtctctac taaaaaaata caaaaaatta     2160

gccgggcttg gtggcgggtg cctgtagtcc cagctactat ggaggctgag gcgggagaat     2220

ggcgtgaacg cggggggcgg agcttgcagt gagcagagat caggggccac tgcactccag     2280

cctgggcgac agagagagac tctgtctcaa aaaaaagaaa aaaaaaattt agtagactag     2340

ctaaaaaaat ccagagatag ttattgatgc atatgtaaaa gtcttccaat atttacaagt     2400

acaatgaaaa aaaaataacc ttgaattaag tgtagaactc attgacaatg tttcaaagga     2460

tgtgagggat aaactaaaat ttgggcagta catgctgttc ctgtgtactt ggaacagagg     2520

gagaaaatct gggctggaaa tattgttata ggagttagca catgaaggtg acaactaaat     2580

tatttggagt agatggagtc accagcacat gtgaatagtt ttagaatgaa atgacccaag     2640

atagaacttt ggagagcccc caaatttaaa taaaatcagt ataagagaag aggaagaaac     2700

caaatggtat actagtctaa attgtttctt agtgacaaaa gaataacctg aatattagat     2760

tagctgccta tatgctctct gaatcaattt cattcaacat gcaacagttc tggaacctat     2820

cagggaccac agtcagccag gcaagcacat ctgcccaagc caagggtgga ggcatgcagc     2880

tgtgggggtc tgtgaaaaca cttgagggag cagataactg ggccaaccat gactcagtgc     2940

ttctggaggc caacaggact gctgagtcat cctgtggggg tggaggtggg acaagggaaa     3000

ggggtgaatg gtactgctga ttacaacctc tggtgctgcc tccccctcct gtttatctga     3060

gagaggcctc actggagcta gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg     3120

gtatcctcta tgatgggaga aggaaactag ctaaagggaa gaataaatta gagaaaaact     3180

ggaatgactg aatcggaaca aggcaaaggc tataaaaaaa attagcagta tcctcttggg     3240

ggccccttcc ccacactatc tcaatgcaaa tatctgtctg aaacggtccc tggctaaact     3300

ccacccatgg gttggccagc cttgccttga caaggcaaac ttgaccaata gtcttagagt     3360

atccagtgag gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctt     3420

cagcagttcc acacactcgc ttctggaacg tctgaggtta tcaataagct cctagtccag     3480

acgccatggg tcatttcaca gaggaggaca aggctactat cacaagcctg tggggcaagg     3540

tgaatgtgga agatgctgga ggagaaaccc tgggaaggta ggctctggtg accaggacaa     3600

gggagggaag gaaggaccct gtgcctggca aaagtccagg tcgcttctca ggatttgtgg     3660

caccttctga ctgtcaaact gttcttgtca atctcacagg ctcctggttg tctacccatg     3720

gacccagagg ttctttgaca gctttggcaa cctgtcctct gcctctgcca tcatgggcaa     3780

ccccaaagtc aaggcacatg gcaagaaggt gctgacttcc ttgggagatg ccacaaagca     3840

cctggatgat ctcaagggca cctttgccca gctgagtgaa ctgcactgtg acaagctgca     3900

tgtggatcct gagaacttca aggtgagtcc aggagatgtt tcagccctgt tgcctttagt     3960

ctcgaggcaa cttagacaac ggagtattga tctgagcaca gcagggtgtg agctgtttga     4020

agatactggg gttgggggtg aagaaactgc agaggactaa ctgggctgag acccagtggt     4080

aatgttttag ggcctaagga gtgcctctaa aaatctagat ggacaatttt gactttgaga     4140

aaagagaggt ggaaatgagg aaaatgactt ttctttatta gattccagta gaaagaactt     4200

tcatctttcc ctcatttttg ttgttttaaa agtcgacagg aacccctagt gatggagttg     4260

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     4320

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg gcgtaatagc     4380

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcga     4440

ttccgttgca atggctggcg gtaatattgt tctggatatt accagcaagg ccgatagttt     4500

gagttcttct actcaggcaa gtgatgttat tactaatcaa agaagtattg cgacaacggt     4560

taatttgcgt gatggacaga ctcttttact cggtggcctc actgattata aaaacacttc     4620

tcaggattct ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc tgtttagctc     4680

ccgctctgat tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg     4740

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     4800

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     4860

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     4920

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     4980

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     5040

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     5100

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     5160

cgaattttaa caaaatatta acgtttacaa tttaaatatt tgcttataca atcttcctgt     5220

ttttggggct tttctgatta tcaaccgggg tacatatgat tgacatgcta gttttacgat     5280

taccgttcat cgattctctt gtttgctcca gactctcagg caatgacctg atagcctttg     5340

tagagacctc tcaaaaatag ctaccctctc cggcatgaat ttatcagcta gaacggttga     5400

atatcatatt gatggtgatt tgactgtctc cggcctttct cacccgtttg aatctttacc     5460

tacacattac tcaggcattg catttaaaat atatgagggt tctaaaaatt tttatccttg     5520

cgttgaaata aaggcttctc ccgcaaaagt attacagggt cataatgttt ttggtacaac     5580

cgatttagct ttatgctctg aggctttatt gcttaatttt gctaattctt tgccttgcct     5640

gtatgattta ttggatgttg gaatcgcctg atgcggtatt ttctccttac gcatctgtgc     5700

ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta     5760

agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg     5820

gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca     5880

ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt     5940

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     6000

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     6060

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     6120

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     6180

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     6240

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6300

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa     6360

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6420

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6480

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6540

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6600

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca     6660

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6720

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6780

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6840

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6900

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6960

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     7020

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     7080

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     7140

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     7200

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     7260

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac     7320

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7380

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7440

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7500

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7560

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7620

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7680

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7740

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7800

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7860

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7920

ccgcctctcc ccgcgcgttg gccgattcat taatg                                7955


<210>  39
<211>  7825
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  39
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccgcgggct ttaaaaaacc      660

tcccacatct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt      720

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag      780

ctagaatggt tacaaataaa gcaatagcat cacaaatttc acaaataaac accacggaat      840

tgtcagtgcc caacagccga gcccctgtcc agcagcgggc aaggcaggcg gcgatgagtt      900

ccgccgtggc aagaactaac caggatttat acaaggagga gaaaatgaaa gccatacggg      960

aagcaatagc atgatacaaa ggcattaaag cagcgtatcc acatagcgta aaaggagcaa     1020

catagttaag aataccagtc aatctttcac aaattttgta atccagaggt tgattatccc     1080

tgcaggttac ttgtacagct cgtccatgcc gagagtgatc ccggcggcgg tcacgaactc     1140

cagcaggacc atgtgatcgc gcttctcgtt ggggtctttg ctcagggcgg actgggtgct     1200

caggtagtgg ttgtcgggca gcagcacggg gccgtcgccg atgggggtgt tctgctggta     1260

gtggtcggcg agctgcacgc tgccgtcctc gatgttgtgg cggatcttga agttcacctt     1320

gatgccgttc ttctgcttgt cggccatgat atagacgttg tggctgttgt agttgtactc     1380

cagcttgtgc cccaggatgt tgccgtcctc cttgaagtcg atgcccttca gctcgatgcg     1440

gttcaccagg gtgtcgccct cgaacttcac ctcggcgcgg gtcttgtagt tgccgtcgtc     1500

cttgaagaag atggtgcgct cctggacgta gccttcgggc atggcggact tgaagaagtc     1560

gtgctgcttc atgtggtcgg ggtagcggct gaagcactgc acgccgtagg tcagggtggt     1620

cacgagggtg ggccagggca cgggcagctt gccggtggtg cagatgaact tcagggtcag     1680

cttgccgtag gtggcatcgc cctcgccctc gccggacacg ctgaacttgt ggccgtttac     1740

gtcgccgtcc agctcgacca ggatgggcac caccccggtg aacagctcct cgcccttgct     1800

caccatggtg gcggcgcggc cgccttctat ggaagtcaaa acagcgtgga tggcgtctcc     1860

aggcgatctg acggttcact aaacgagctc tgcttatata gagctcgggg agcagaagcg     1920

cgcgaacaga agcgagaagc gaactgattg gttagttcaa ataaggcaca gggtcatttc     1980

aggtccttgg ggcaccctgg aaacatctga tggttctcta gaaactgctg agggcgggac     2040

cgcatctggg gaccatctgt tcttggccct gagccggggc aggaactgct taccacagat     2100

atcctgtttg gcccatattc tgctgttcca actgttcttg gccctgagcc ggggcaggaa     2160

ctgcttacca cagatatcct gtttggccca tattctcctg tttctctgtt cgaattccga     2220

gatcgagacc atcctggcta acacagtgaa accccgtctc tactaaaaaa atacaaaaaa     2280

ttagccgggc ttggtggcgg gtgcctgtag tcccagctac tatggaggct gaggcgggag     2340

aatggcgtga acgcgggggg cggagcttgc agtgagcaga gatcaggggc cactgcactc     2400

cagcctgggc gacagagaga gactctgtct caaaaaaaag aaaaaaaaaa tttagtagac     2460

tagctaaaaa aatccagaga tagttattga tgcatatgta aaagtcttcc aatatttaca     2520

agtacaatga aaaaaaaata accttgaatt aagtgtagaa ctcattgaca atgtttcaaa     2580

ggatgtgagg gataaactaa aatttgggca gtacatgctg ttcctgtgta cttggaacag     2640

agggagaaaa tctgggctgg aaatattgtt ataggagtta gcacatgaag gtgacaacta     2700

aattatttgg agtagatgga gtcaccagca catgtgaata gttttagaat gaaatgaccc     2760

aagatagaac tttggagagc ccccaaattt aaataaaatc agtataagag aagaggaaga     2820

aaccaaatgg tatactagtc taaattgttt cttagtgaca aaagaataac ctgaatatta     2880

gattagctgc ctatatgctc tctgaatcaa tttcattcaa catgcaacag ttctggaacc     2940

tatcagggac cacagtcagc caggcaagca catctgccca agccaagggt ggaggcatgc     3000

agctgtgggg gtctgtgaaa acacttgagg gagcagataa ctgggccaac catgactcag     3060

tgcttctgga ggccaacagg actgctgagt catcctgtgg gggtggaggt gggacaaggg     3120

aaaggggtga atggtactgc tgattacaac ctctggtgct gcctccccct cctgtttatc     3180

tgagaggcta gcgtaaatac acttgcaaag gaggatgttt ttagtagcaa tttgtactga     3240

tggtatgggg ccaagagata tatcttagag ggagggctga gggtttgaag tccaactcct     3300

aagccagtgc cagaagagcc aaggacaggt acggctgtca tcacttagac ctcaccctgt     3360

ggagccacac cctagggttg gccaatctac tcccaggagc agggagggca ggagccaggg     3420

ctgggcataa aagtcagggc agagccatct attgcttaca ctcgcttctg gaacgtctga     3480

ggttatcaat aagctcctag tccagacgcc atgggtcatt tcacagagga ggacaaggct     3540

actatcacaa gcctgtgggg caaggtgaat gtggaagatg ctggaggaga aaccctggga     3600

aggtaggctc tggtgaccag gacaagggag ggaaggaagg accctgtgcc tggcaaaagt     3660

ccaggtcgct tctcaggatt tgtggcacct tctgactgtc aaactgttct tgtcaatctc     3720

acaggctcct ggttgtctac ccatggaccc agaggttctt tgacagcttt ggcaacctgt     3780

cctctgcctc tgccatcatg ggcaacccca aagtcaaggc acatggcaag aaggtgctga     3840

cttccttggg agatgccaca aagcacctgg atgatctcaa gggcaccttt gcccagctga     3900

gtgaactgca ctgtgacaag ctgcatgtgg atcctgagaa cttcaaggtg agtccaggag     3960

atgtttcagc cctgttgcct ttagtctcga ggcaacttag acaacggagt attgatctga     4020

gcacagcagg gtgtgagctg tttgaagata ctggggtctc gaggtcgacg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4200

tgcccgggcg gcctcagtga gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc     4260

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcga ttccgttgca     4320

atggctggcg gtaatattgt tctggatatt accagcaagg ccgatagttt gagttcttct     4380

actcaggcaa gtgatgttat tactaatcaa agaagtattg cgacaacggt taatttgcgt     4440

gatggacaga ctcttttact cggtggcctc actgattata aaaacacttc tcaggattct     4500

ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc tgtttagctc ccgctctgat     4560

tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag     4620

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     4680

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     4740

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     4800

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     4860

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     4920

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     4980

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     5040

caaaatatta acgtttacaa tttaaatatt tgcttataca atcttcctgt ttttggggct     5100

tttctgatta tcaaccgggg tacatatgat tgacatgcta gttttacgat taccgttcat     5160

cgattctctt gtttgctcca gactctcagg caatgacctg atagcctttg tagagacctc     5220

tcaaaaatag ctaccctctc cggcatgaat ttatcagcta gaacggttga atatcatatt     5280

gatggtgatt tgactgtctc cggcctttct cacccgtttg aatctttacc tacacattac     5340

tcaggcattg catttaaaat atatgagggt tctaaaaatt tttatccttg cgttgaaata     5400

aaggcttctc ccgcaaaagt attacagggt cataatgttt ttggtacaac cgatttagct     5460

ttatgctctg aggctttatt gcttaatttt gctaattctt tgccttgcct gtatgattta     5520

ttggatgttg gaatcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     5580

accgcatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc     5640

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     5700

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     5760

cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga     5820

taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta     5880

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat     5940

aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc     6000

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga     6060

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca     6120

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt     6180

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     6240

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     6300

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     6360

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     6420

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     6480

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     6540

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     6600

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     6660

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     6720

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     6780

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     6840

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     6900

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     6960

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     7020

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     7080

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     7140

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     7200

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     7260

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     7320

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     7380

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     7440

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     7500

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     7560

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     7620

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     7680

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     7740

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     7800

ccgcgcgttg gccgattcat taatg                                           7825


<210>  40
<211>  7729
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  40
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccgcgggaa cagagaaaca      660

ggagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca      720

agaacagttg gaacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc      780

cccggctcag ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta      840

gagaaccatc agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt      900

gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcta      960

tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt     1020

tgacttccat agaaggcggc cgcgccgcca ccatggacaa ggattgtgaa atgaaacgca     1080

ccacactgga cagccctttg gggaagctgg agctgtctgg ttgtgagcag ggtctgcacg     1140

aaataaagct cctgggcaag gggacgtctg cagctgatgc cgtggaggtc ccagcccccg     1200

ctgcggttct cggaggtccg gagcccctga tgcagtgcac agcctggctg aatgcctatt     1260

tccaccagcc cgaggctatc gaagagttcc ccgtgccggc tcttcaccat cccgttttcc     1320

agcaagagtc gttcaccaga caggtgttat ggaagctgct gaaggttgtg aaattcggag     1380

aagtgatttc ttaccagcaa ttagcagccc tggcaggcaa ccccaaagcc gcgcgagcag     1440

tgggaggagc aatgagaggc aatcctgtca aaatcctcat cccgtgccac agagtggtct     1500

gcagcagcgg agccgtgggc aactactccg gaggactggc cgtgaaggaa tggcttctgg     1560

cccatgaagg ccaccggttg gggaagccag gcttgggagg gagctcaggt ctggcagggg     1620

cctggctcaa gggagcggga gctacctcgg gctccccgcc tgctggccga aactaacctg     1680

cagggataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     1740

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     1800

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttagttc ttgccacggc     1860

ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga     1920

caattccgtg gtgtttattt gtgaaatttg tgatgctatt gctttatttg taaccattct     1980

agctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     2040

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggagatgtgg     2100

gaggtttttt aaagcgaatt ccgagatcga gaccatcctg gctaacacag tgaaaccccg     2160

tctctactaa aaaaatacaa aaaattagcc gggcttggtg gcgggtgcct gtagtcccag     2220

ctactatgga ggctgaggcg ggagaatggc gtgaacgcgg ggggcggagc ttgcagtgag     2280

cagagatcag gggccactgc actccagcct gggcgacaga gagagactct gtctcaaaaa     2340

aaagaaaaaa aaaatttagt agactagcta aaaaaatcca gagatagtta ttgatgcata     2400

tgtaaaagtc ttccaatatt tacaagtaca atgaaaaaaa aataaccttg aattaagtgt     2460

agaactcatt gacaatgttt caaaggatgt gagggataaa ctaaaatttg ggcagtacat     2520

gctgttcctg tgtacttgga acagagggag aaaatctggg ctggaaatat tgttatagga     2580

gttagcacat gaaggtgaca actaaattat ttggagtaga tggagtcacc agcacatgtg     2640

aatagtttta gaatgaaatg acccaagata gaactttgga gagcccccaa atttaaataa     2700

aatcagtata agagaagagg aagaaaccaa atggtatact agtctaaatt gtttcttagt     2760

gacaaaagaa taacctgaat attagattag ctgcctatat gctctctgaa tcaatttcat     2820

tcaacatgca acagttctgg aacctatcag ggaccacagt cagccaggca agcacatctg     2880

cccaagccaa gggtggaggc atgcagctgt gggggtctgt gaaaacactt gagggagcag     2940

ataactgggc caaccatgac tcagtgcttc tggaggccaa caggactgct gagtcatcct     3000

gtgggggtgg aggtgggaca agggaaaggg gtgaatggta ctgctgatta caacctctgg     3060

tgctgcctcc ccctcctgtt tatctgagag gctagcgtaa atacacttgc aaaggaggat     3120

gtttttagta gcaatttgta ctgatggtat ggggccaaga gatatatctt agagggaggg     3180

ctgagggttt gaagtccaac tcctaagcca gtgccagaag agccaaggac aggtacggct     3240

gtcatcactt agacctcacc ctgtggagcc acaccctagg gttggccaat ctactcccag     3300

gagcagggag ggcaggagcc agggctgggc ataaaagtca gggcagagcc atctattgct     3360

tacactcgct tctggaacgt ctgaggttat caataagctc ctagtccaga cgccatgggt     3420

catttcacag aggaggacaa ggctactatc acaagcctgt ggggcaaggt gaatgtggaa     3480

gatgctggag gagaaaccct gggaaggtag gctctggtga ccaggacaag ggagggaagg     3540

aaggaccctg tgcctggcaa aagtccaggt cgcttctcag gatttgtggc accttctgac     3600

tgtcaaactg ttcttgtcaa tctcacaggc tcctggttgt ctacccatgg acccagaggt     3660

tctttgacag ctttggcaac ctgtcctctg cctctgccat catgggcaac cccaaagtca     3720

aggcacatgg caagaaggtg ctgacttcct tgggagatgc cacaaagcac ctggatgatc     3780

tcaagggcac ctttgcccag ctgagtgaac tgcactgtga caagctgcat gtggatcctg     3840

agaacttcaa ggtgagtcca ggagatgttt cagccctgtt gcctttagtc tcgaggcaac     3900

ttagacaacg gagtattgat ctgagcacag cagggtgtga gctgtttgaa gatactgggg     3960

tctcgaggtc gacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct     4020

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4080

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca     4140

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     4200

atggcgaatg gcgattccgt tgcaatggct ggcggtaata ttgttctgga tattaccagc     4260

aaggccgata gtttgagttc ttctactcag gcaagtgatg ttattactaa tcaaagaagt     4320

attgcgacaa cggttaattt gcgtgatgga cagactcttt tactcggtgg cctcactgat     4380

tataaaaaca cttctcagga ttctggcgta ccgttcctgt ctaaaatccc tttaatcggc     4440

ctcctgttta gctcccgctc tgattctaac gaggaaagca cgttatacgt gctcgtcaaa     4500

gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4560

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4620

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4680

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     4740

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     4800

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     4860

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     4920

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttaaa tatttgctta     4980

tacaatcttc ctgtttttgg ggcttttctg attatcaacc ggggtacata tgattgacat     5040

gctagtttta cgattaccgt tcatcgattc tcttgtttgc tccagactct caggcaatga     5100

cctgatagcc tttgtagaga cctctcaaaa atagctaccc tctccggcat gaatttatca     5160

gctagaacgg ttgaatatca tattgatggt gatttgactg tctccggcct ttctcacccg     5220

tttgaatctt tacctacaca ttactcaggc attgcattta aaatatatga gggttctaaa     5280

aatttttatc cttgcgttga aataaaggct tctcccgcaa aagtattaca gggtcataat     5340

gtttttggta caaccgattt agctttatgc tctgaggctt tattgcttaa ttttgctaat     5400

tctttgcctt gcctgtatga tttattggat gttggaatcg cctgatgcgg tattttctcc     5460

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg     5520

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     5580

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     5640

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     5700

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     5760

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     5820

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     5880

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     5940

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6000

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6060

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6120

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6180

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     6240

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     6300

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6360

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6420

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6480

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6540

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6600

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6660

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     6720

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6780

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     6840

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     6900

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     6960

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7020

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7080

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7140

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7200

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7260

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7320

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7380

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7440

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7500

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7560

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7620

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     7680

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatg                 7729


<210>  41
<211>  7855
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  41
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccgcggcca cggggttggg      660

gttgcgcctt ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg      720

ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag      780

cgtcacccgg atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc      840

cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc      900

acgtctcact agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc      960

gcgatgggct gtggccaata gcggctgctc agcggggcgc gccgagagca gcggccggga     1020

aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg     1080

gtgttccgca ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg     1140

aatcaccgac ctctctcccc agcggccgcg ccgccaccat ggacaaggat tgtgaaatga     1200

aacgcaccac actggacagc cctttgggga agctggagct gtctggttgt gagcagggtc     1260

tgcacgaaat aaagctcctg ggcaagggga cgtctgcagc tgatgccgtg gaggtcccag     1320

cccccgctgc ggttctcgga ggtccggagc ccctgatgca gtgcacagcc tggctgaatg     1380

cctatttcca ccagcccgag gctatcgaag agttccccgt gccggctctt caccatcccg     1440

ttttccagca agagtcgttc accagacagg tgttatggaa gctgctgaag gttgtgaaat     1500

tcggagaagt gatttcttac cagcaattag cagccctggc aggcaacccc aaagccgcgc     1560

gagcagtggg aggagcaatg agaggcaatc ctgtcaaaat cctcatcccg tgccacagag     1620

tggtctgcag cagcggagcc gtgggcaact actccggagg actggccgtg aaggaatggc     1680

ttctggccca tgaaggccac cggttgggga agccaggctt gggagggagc tcaggtctgg     1740

caggggcctg gctcaaggga gcgggagcta cctcgggctc cccgcctgct ggccgaaact     1800

aacctgcagg gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct     1860

taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc     1920

tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt tagttcttgc     1980

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     2040

cactgacaat tccgtggtgt ttatttgtga aatttgtgat gctattgctt tatttgtaac     2100

cattctagct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     2160

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     2220

atgtgggagg ttttttaaag cgaattccga gatcgagacc atcctggcta acacagtgaa     2280

accccgtctc tactaaaaaa atacaaaaaa ttagccgggc ttggtggcgg gtgcctgtag     2340

tcccagctac tatggaggct gaggcgggag aatggcgtga acgcgggggg cggagcttgc     2400

agtgagcaga gatcaggggc cactgcactc cagcctgggc gacagagaga gactctgtct     2460

caaaaaaaag aaaaaaaaaa tttagtagac tagctaaaaa aatccagaga tagttattga     2520

tgcatatgta aaagtcttcc aatatttaca agtacaatga aaaaaaaata accttgaatt     2580

aagtgtagaa ctcattgaca atgtttcaaa ggatgtgagg gataaactaa aatttgggca     2640

gtacatgctg ttcctgtgta cttggaacag agggagaaaa tctgggctgg aaatattgtt     2700

ataggagtta gcacatgaag gtgacaacta aattatttgg agtagatgga gtcaccagca     2760

catgtgaata gttttagaat gaaatgaccc aagatagaac tttggagagc ccccaaattt     2820

aaataaaatc agtataagag aagaggaaga aaccaaatgg tatactagtc taaattgttt     2880

cttagtgaca aaagaataac ctgaatatta gattagctgc ctatatgctc tctgaatcaa     2940

tttcattcaa catgcaacag ttctggaacc tatcagggac cacagtcagc caggcaagca     3000

catctgccca agccaagggt ggaggcatgc agctgtgggg gtctgtgaaa acacttgagg     3060

gagcagataa ctgggccaac catgactcag tgcttctgga ggccaacagg actgctgagt     3120

catcctgtgg gggtggaggt gggacaaggg aaaggggtga atggtactgc tgattacaac     3180

ctctggtgct gcctccccct cctgtttatc tgagaggcta gcgtaaatac acttgcaaag     3240

gaggatgttt ttagtagcaa tttgtactga tggtatgggg ccaagagata tatcttagag     3300

ggagggctga gggtttgaag tccaactcct aagccagtgc cagaagagcc aaggacaggt     3360

acggctgtca tcacttagac ctcaccctgt ggagccacac cctagggttg gccaatctac     3420

tcccaggagc agggagggca ggagccaggg ctgggcataa aagtcagggc agagccatct     3480

attgcttaca ctcgcttctg gaacgtctga ggttatcaat aagctcctag tccagacgcc     3540

atgggtcatt tcacagagga ggacaaggct actatcacaa gcctgtgggg caaggtgaat     3600

gtggaagatg ctggaggaga aaccctggga aggtaggctc tggtgaccag gacaagggag     3660

ggaaggaagg accctgtgcc tggcaaaagt ccaggtcgct tctcaggatt tgtggcacct     3720

tctgactgtc aaactgttct tgtcaatctc acaggctcct ggttgtctac ccatggaccc     3780

agaggttctt tgacagcttt ggcaacctgt cctctgcctc tgccatcatg ggcaacccca     3840

aagtcaaggc acatggcaag aaggtgctga cttccttggg agatgccaca aagcacctgg     3900

atgatctcaa gggcaccttt gcccagctga gtgaactgca ctgtgacaag ctgcatgtgg     3960

atcctgagaa cttcaaggtg agtccaggag atgtttcagc cctgttgcct ttagtctcga     4020

ggcaacttag acaacggagt attgatctga gcacagcagg gtgtgagctg tttgaagata     4080

ctggggtctc gaggtcgacg tagataagta gcatggcggg ttaatcatta actacaagga     4140

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     4200

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     4260

gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca     4320

gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt tctggatatt     4380

accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat tactaatcaa     4440

agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact cggtggcctc     4500

actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa aatcccttta     4560

atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt atacgtgctc     4620

gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     4680

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     4740

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     4800

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     4860

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     4920

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     4980

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     5040

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa tttaaatatt     5100

tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg tacatatgat     5160

tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca gactctcagg     5220

caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc cggcatgaat     5280

ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc cggcctttct     5340

cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat atatgagggt     5400

tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt attacagggt     5460

cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt gcttaatttt     5520

gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg atgcggtatt     5580

ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct     5640

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     5700

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     5760

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     5820

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     5880

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     5940

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     6000

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     6060

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     6120

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     6180

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     6240

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     6300

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     6360

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     6420

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     6480

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     6540

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     6600

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     6660

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     6720

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     6780

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     6840

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     6900

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     6960

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     7020

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     7080

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     7140

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     7200

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     7260

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     7320

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     7380

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     7440

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     7500

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     7560

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     7620

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     7680

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     7740

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     7800

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatg          7855


<210>  42
<211>  8024
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  42
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg aggtaagcat      240

taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc tttatagaaa      300

ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca aagagtatat      360

tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag agactaagat      420

ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc ctgaactttt      480

caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta gagacaagaa      540

ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga aggaaactag      600

ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca aggcaaaggc      660

tataaaaaaa attagcagta tcctcttggg ggccccttcc ccacactatc tcaatgcaaa      720

tatctgtctg aaacggtccc tggctaaact ccacccatgg gttggccagc cttgccttga      780

caaggcaaac ttgaccaata gtcttagagt atccagtgag gccaggggcc ggcggctggc      840

tagggatgaa gaataaaagg aagcaccctt cagcagttcc acacactcgc ttctggaacg      900

tctgaggtta tcaataagct cctagtccag acgccatggt gcacctgact cctgaggaga      960

agtctgccgt tactgccctg tggggcaagg tgaacgtgga tgaagttggt ggtgaggccc     1020

tgggcaggtt ggtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggcat     1080

gtggagacag agaagactct tgggtttctg ataggcactg actctctctg cctattggtc     1140

tattttccca cccttaggct gctggtggtc tacccttgga cccagaggtt ctttgagtcc     1200

tttggggatc tgtccactcc tgatgctgtt atgggcaacc ctaaggtgaa ggctcatggc     1260

aagaaagtgc tcggtgcctt tagtgatggc ctggctcacc tggacaacct caagggcacc     1320

tttgcccagc tgagtgagct gcactgtgac aagctgcacg tggatcctga gaacttcagg     1380

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt     1440

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt     1500

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat     1560

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca     1620

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata     1680

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc     1740

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga     1800

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagctcc     1860

tgggcaacgt gctggtctgt gtgctggccc atcactttgg caaagaattc accccaccag     1920

tgcaggctgc ctatcagaaa gtggtggctg gtgtggctaa tgccctggcc cacaagtatc     1980

actaagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca     2040

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa     2100

acatttattt tcattgcaat gatgtattta aattatttct gaatatttta ctaaaaaggg     2160

aatgtgggag gttgcagtgc tagtctcccg gaactatcac tctttcacag tctgctttgg     2220

aaggactggg cttagtatga aaagttagga ctgagaagaa tttgaaaggg ggctttttgt     2280

agcttgatat tcactactgt cttattaccc tatcataggc ccaccccaaa tggaagtccc     2340

attcttcctc aggatgttta agattagcat tcaggaagag atcagaggtc tgctggctcc     2400

cttatcatgt cccttatggt gcttctggct ctgcaccgcg gccacggggt tggggttgcg     2460

ccttttccaa ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg     2520

gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac     2580

ccggatcttc gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag     2640

tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct     2700

cactagtacc ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg     2760

ggctgtggcc aatagcggct gctcagcggg gcgcgccgag agcagcggcc gggaaggggc     2820

ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc     2880

cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac     2940

cgacctctct ccccagcggc cgcgccgcca ccatggacaa ggattgtgaa atgaaacgca     3000

ccacactgga cagccctttg gggaagctgg agctgtctgg ttgtgagcag ggtctgcacg     3060

aaataaagct cctgggcaag gggacgtctg cagctgatgc cgtggaggtc ccagcccccg     3120

ctgcggttct cggaggtccg gagcccctga tgcagtgcac agcctggctg aatgcctatt     3180

tccaccagcc cgaggctatc gaagagttcc ccgtgccggc tcttcaccat cccgttttcc     3240

agcaagagtc gttcaccaga caggtgttat ggaagctgct gaaggttgtg aaattcggag     3300

aagtgatttc ttaccagcaa ttagcagccc tggcaggcaa ccccaaagcc gcgcgagcag     3360

tgggaggagc aatgagaggc aatcctgtca aaatcctcat cccgtgccac agagtggtct     3420

gcagcagcgg agccgtgggc aactactccg gaggactggc cgtgaaggaa tggcttctgg     3480

cccatgaagg ccaccggttg gggaagccag gcttgggagg gagctcaggt ctggcagggg     3540

cctggctcaa gggagcggga gctacctcgg gctccccgcc tgctggccga aacgagggca     3600

gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc gggcccccct gcaggaactt     3660

caaggtgagt ccaggagatg tttcagccct gttgccttta gtctcgaggc aacttagaca     3720

acggagtatt gatctgagca cagcagggtg tgagctgttt gaagatactg gggttggggg     3780

tgaagaaact gcagaggact aactgggctg agacccagtg gtaatgtttt agggcctaag     3840

gagtgcctct aaaaatctag atggacaatt ttgactttga gaaaagagag gtggaaatga     3900

ggaaaatgac ttttctttat tagattccag tagaaagaac tttcatcttt ccctcatttt     3960

tgttgtttta aaacatctat ctggaggcag gacaagtatg gtcgttaaaa agatgcaggc     4020

agaaggcata tattggctca gtcaaagtgg ggaactttgg tggccaaaca tacattgcta     4080

aggctattcc tatatcagct ggacacatat aaaatgctgc taatgcttca ttacaaactt     4140

atatccttta attccagatg ggggcaaagt atgtccaggg gtgaggaaca attgaaacat     4200

ttgggctgga gtagattttg aaagtcagct ctgtgtgtgt gtgtgtgtgt gcgcgcgcgc     4260

gtgtcgacgt agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga     4320

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     4380

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgccagctgg     4440

cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc     4500

gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta ccagcaaggc     4560

cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa gaagtattgc     4620

gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca ctgattataa     4680

aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa tcggcctcct     4740

gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg tcaaagcaac     4800

catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     4860

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     4920

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     4980

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     5040

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     5100

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     5160

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     5220

aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt gcttatacaa     5280

tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt gacatgctag     5340

ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc aatgacctga     5400

tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt tatcagctag     5460

aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc acccgtttga     5520

atctttacct acacattact caggcattgc atttaaaata tatgagggtt ctaaaaattt     5580

ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc ataatgtttt     5640

tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg ctaattcttt     5700

gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt tctccttacg     5760

catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg ctctgatgcc     5820

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     5880

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     5940

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     6000

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     6060

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     6120

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     6180

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     6240

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     6300

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     6360

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     6420

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     6480

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     6540

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     6600

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     6660

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     6720

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     6780

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     6840

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     6900

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     6960

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     7020

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     7080

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     7140

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     7200

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     7260

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     7320

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     7380

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     7440

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7500

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7560

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     7620

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     7680

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     7740

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     7800

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     7860

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     7920

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca     7980

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg                      8024


<210>  43
<211>  7953
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  43
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg aggtaagcat      240

taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc tttatagaaa      300

ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca aagagtatat      360

tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag agactaagat      420

ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc ctgaactttt      480

caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta gagacaagaa      540

ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga aggaaactag      600

ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca aggcaaaggc      660

tataaaaaaa attagcagta tcctcttggg ggccccttcc ccacactatc tcaatgcaaa      720

tatctgtctg aaacggtccc tggctaaact ccacccatgg gttggccagc cttgccttga      780

caaggcaaac ttgaccaata gtcttagagt atccagtgag gccaggggcc ggcggctggc      840

tagggatgaa gaataaaagg aagcaccctt cagcagttcc acacactcgc ttctggaacg      900

tctgaggtta tcaataagct cctagtccag acgccatggt gcacctgact cctgaggaga      960

agtctgccgt tactgccctg tggggcaagg tgaacgtgga tgaagttggt ggtgaggccc     1020

tgggcaggtt ggtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggcat     1080

gtggagacag agaagactct tgggtttctg ataggcactg actctctctg cctattggtc     1140

tattttccca cccttaggct gctggtggtc tacccttgga cccagaggtt ctttgagtcc     1200

tttggggatc tgtccactcc tgatgctgtt atgggcaacc ctaaggtgaa ggctcatggc     1260

aagaaagtgc tcggtgcctt tagtgatggc ctggctcacc tggacaacct caagggcacc     1320

tttgcccagc tgagtgagct gcactgtgac aagctgcacg tggatcctga gaacttcagg     1380

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt     1440

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt     1500

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat     1560

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca     1620

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata     1680

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc     1740

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga     1800

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagctcc     1860

tgggcaacgt gctggtctgt gtgctggccc atcactttgg caaagaattc accccaccag     1920

tgcaggctgc ctatcagaaa gtggtggctg gtgtggctaa tgccctggcc cacaagtatc     1980

actaagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca     2040

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa     2100

acatttattt tcattgcaat gatgtattta aattatttct gaatatttta ctaaaaaggg     2160

aatgtgggag gttgcagtgc tagtctcccg gaactatcac tctttcacag tctgctttgg     2220

aaggactggg cttagtatga aaagttagga ctgagaagaa tttgaaaggg ggctttttgt     2280

agcttgatat tcactactgt cttattaccc tatcataggc ccaccccaaa tggaagtccc     2340

attcttcctc aggatgttta agattagcat tcaggaagag atcagaggtc tgctggctcc     2400

cttatcatgt cccttatggt gcttctggct ctgcaccgcg ggaacagaga aacaggagaa     2460

tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca     2520

gttggaacag cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc     2580

tcagggccaa gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac     2640

catcagatgt ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta     2700

accaatcagt tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tctatataag     2760

cagagctcgt ttagtgaacc gtcagatcgc ggccgcgccg ccaccatggt gagcaagggc     2820

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc     2880

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg     2940

aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg     3000

acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc     3060

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc     3120

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag     3180

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     3240

tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac     3300

ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag     3360

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag     3420

tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     3480

accgccgccg ggatcactct cggcatggac gagctgtaca aggagggcag aggaagtctt     3540

ctaacatgcg gtgacgtgga ggagaatccg ggcccccctg caggaacttc aaggtgagtc     3600

caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa cggagtattg     3660

atctgagcac agcagggtgt gagctgtttg aagatactgg ggttgggggt gaagaaactg     3720

cagaggacta actgggctga gacccagtgg taatgtttta gggcctaagg agtgcctcta     3780

aaaatctaga tggacaattt tgactttgag aaaagagagg tggaaatgag gaaaatgact     3840

tttctttatt agattccagt agaaagaact ttcatctttc cctcattttt gttgttttaa     3900

aacatctatc tggaggcagg acaagtatgg tcgttaaaaa gatgcaggca gaaggcatat     3960

attggctcag tcaaagtggg gaactttggt ggccaaacat acattgctaa ggctattcct     4020

atatcagctg gacacatata aaatgctgct aatgcttcat tacaaactta tatcctttaa     4080

ttccagatgg gggcaaagta tgtccagggg tgaggaacaa ttgaaacatt tgggctggag     4140

tagattttga aagtcagctc tgtgtgtgtg tgtgtgtgtg cgcgcgcgcg tgtcgacgta     4200

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4260

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4320

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gccagctggc gtaatagcga     4380

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgatt     4440

ccgttgcaat ggctggcggt aatattgttc tggatattac cagcaaggcc gatagtttga     4500

gttcttctac tcaggcaagt gatgttatta ctaatcaaag aagtattgcg acaacggtta     4560

atttgcgtga tggacagact cttttactcg gtggcctcac tgattataaa aacacttctc     4620

aggattctgg cgtaccgttc ctgtctaaaa tccctttaat cggcctcctg tttagctccc     4680

gctctgattc taacgaggaa agcacgttat acgtgctcgt caaagcaacc atagtacgcg     4740

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     4800

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     4860

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     4920

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     4980

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     5040

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     5100

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     5160

aattttaaca aaatattaac gtttacaatt taaatatttg cttatacaat cttcctgttt     5220

ttggggcttt tctgattatc aaccggggta catatgattg acatgctagt tttacgatta     5280

ccgttcatcg attctcttgt ttgctccaga ctctcaggca atgacctgat agcctttgta     5340

gagacctctc aaaaatagct accctctccg gcatgaattt atcagctaga acggttgaat     5400

atcatattga tggtgatttg actgtctccg gcctttctca cccgtttgaa tctttaccta     5460

cacattactc aggcattgca tttaaaatat atgagggttc taaaaatttt tatccttgcg     5520

ttgaaataaa ggcttctccc gcaaaagtat tacagggtca taatgttttt ggtacaaccg     5580

atttagcttt atgctctgag gctttattgc ttaattttgc taattctttg ccttgcctgt     5640

atgatttatt ggatgttgga atcgcctgat gcggtatttt ctccttacgc atctgtgcgg     5700

tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag     5760

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     5820

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     5880

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     5940

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     6000

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     6060

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     6120

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     6180

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     6240

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     6300

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     6360

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     6420

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     6480

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     6540

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     6600

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     6660

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     6720

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     6780

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     6840

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     6900

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     6960

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     7020

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     7080

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     7140

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     7200

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     7260

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     7320

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     7380

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     7440

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     7500

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc     7560

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     7620

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     7680

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     7740

tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc     7800

tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg     7860

aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc     7920

gcctctcccc gcgcgttggc cgattcatta atg                                  7953


<210>  44
<211>  7553
<212>  DNA
<213>  Artificial

<220>
<223>  45

<400>  44
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttccttaga aaccactgct aactgaaaga gactaagatt tgtcccgtca aaaatcctgg      240

acctatgcct aaaacacatt tcacaatccc tgaacttttc aaaaattggt acatgcttta      300

gctttaaact acaggcctca ctggagctag agacaagaag gtaaaaaacg gctgacaaaa      360

gaagtcctgg tatcctctat gatgggagaa ggaaactagc taaagggaag aataaattag      420

agaaaaactg gaatgactga atcggaacaa ggcaaaggct ataaaaaaaa ttagcagtat      480

cctcttgggg gccccttccc cacactatct caatgcaaat atctgtctga aacggtccct      540

ggctaaactc cacccatggg ttggccagcc ttgccttgac aaggcaaact tgaccaatag      600

tcttagagta tccagtgagg ccaggggccg gcggctggct agggatgaag aataaaagga      660

agcacccttc agcagttcca cacactcgct tctggaacgt ctgaggttat caataagctc      720

ctagtccaga cgccatggtg cacctgactc ctgaggagaa gtctgccgtt actgccctgt      780

ggggcaaggt gaacgtggat gaagttggtg gtgaggccct gggcaggttg gtatcaaggt      840

tacaagacag gtttaaggag accaatagaa actgggcatg tggagacaga gaagactctt      900

gggtttctga taggcactga ctctctctgc ctattggtct attttcccac ccttaggctg      960

ctggtggtct acccttggac ccagaggttc tttgagtcct ttggggatct gtccactcct     1020

gatgctgtta tgggcaaccc taaggtgaag gctcatggca agaaagtgct cggtgccttt     1080

agtgatggcc tggctcacct ggacaacctc aagggcacct ttgcccagct gagtgagctg     1140

cactgtgaca agctgcacgt ggatcctgag aacttcaggg tgagtctatg ggacccttga     1200

tgttttcttt ccccttcttt tctatggtta agttcatgtc ataggaaggg gagaagtaac     1260

agggtacaca tattgaccaa atcagggtaa ttttgcattt gtaattttaa aaaatgcttt     1320

cttcttttaa tatacttttt tgtttatctt atttctaata ctttccctaa tctctttctt     1380

tcagggcaat aatgatacaa tgtatcatgc ctctttgcac cattctaaag aataacagtg     1440

ataatttctg ggttaaggca atagcaatat ttctgcatat aaatatttct gcatataaat     1500

tgtaactgat gtaagaggtt tcatattgct aatagcagct acaatccagc taccattctg     1560

cttttatttt atggttggga taaggctgga ttattctgag tccaagctag gcccttttgc     1620

taatcatgtt catacctctt atcttcctcc cacagctcct gggcaacgtg ctggtctgtg     1680

tgctggccca tcactttggc aaagaattca ccccaccagt gcaggctgcc tatcagaaag     1740

tggtggctgg tgtggctaat gccctggccc acaagtatca ctaagctcgc tttcttgctg     1800

tccaatttct attaaaggtt cctttgttcc ctaagtccaa ctactaaact gggggatatt     1860

atgaagggcc ttgagcatct ggattctgcc taataaaaaa catttatttt cattgcaatg     1920

atgtatttaa attatttctg aatattttac taaaaaggga atgtgggagg ttgcagtgct     1980

agtctcccgg aactatcact ctttcacagt ctgctttgga aggactgggc ttagtatgaa     2040

aagttaggac tgagaagaat ttgaaagggg gctttttgta gcttgatatt cactactgtc     2100

ttattaccct atcataggcc caccccaaat ggaagtccca ttcttcctca ggatgtttaa     2160

gattagcatt caggaagaga tcagaggtct gctggctccc ttatcatgtc ccttatggtg     2220

cttctggctc tgcaccgcgg gaacagagaa acaggagaat atgggccaaa caggatatct     2280

gtggtaagca gttcctgccc cggctcaggg ccaagaacag ttggaacagc agaatatggg     2340

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt     2400

ccccagatgc ggtcccgccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc     2460

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc     2520

ttctgttcgc gcgcttctgc tccccgagct ctatataagc agagctcgtt tagtgaaccg     2580

tcagatcgcg gccgcgccgc caccatggtg agcaagggcg aggagctgtt caccggggtg     2640

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     2700

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     2760

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc     2820

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     2880

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     2940

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     3000

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     3060

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     3120

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     3180

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     3240

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     3300

ggcatggacg agctgtacaa ggagggcaga ggaagtcttc taacatgcgg tgacgtggag     3360

gagaatccgg gcccccctgc aggaacttca aggtgagtcc aggagatgtt tcagccctgt     3420

tgcctttagt ctcgaggcaa cttagacaac ggagtattga tctgagcaca gcagggtgtg     3480

agctgtttga agatactggg gttgggggtg aagaaactgc agaggactaa ctgggctgag     3540

acccagtggt aatgttttag ggcctaagga gtgcctctaa aaatctagat ggacaatttt     3600

gactttgaga aaagagaggt ggaaatgagg aaaatgactt ttctttatta gattccagta     3660

gaaagaactt tcatctttcc ctcatttttg ttgttttaaa acatctatct ggaggcagga     3720

caagtatggt cgttaaaaag atgcaggcag aaggcatata ttggctcagt caaagtgggg     3780

aactttggtg ggtcgacgta gataagtagc atggcgggtt aatcattaac tacaaggaac     3840

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3900

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3960

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     4020

ctgaatggcg aatggcgatt ccgttgcaat ggctggcggt aatattgttc tggatattac     4080

cagcaaggcc gatagtttga gttcttctac tcaggcaagt gatgttatta ctaatcaaag     4140

aagtattgcg acaacggtta atttgcgtga tggacagact cttttactcg gtggcctcac     4200

tgattataaa aacacttctc aggattctgg cgtaccgttc ctgtctaaaa tccctttaat     4260

cggcctcctg tttagctccc gctctgattc taacgaggaa agcacgttat acgtgctcgt     4320

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     4380

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     4440

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     4500

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     4560

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     4620

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     4680

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     4740

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt taaatatttg     4800

cttatacaat cttcctgttt ttggggcttt tctgattatc aaccggggta catatgattg     4860

acatgctagt tttacgatta ccgttcatcg attctcttgt ttgctccaga ctctcaggca     4920

atgacctgat agcctttgta gagacctctc aaaaatagct accctctccg gcatgaattt     4980

atcagctaga acggttgaat atcatattga tggtgatttg actgtctccg gcctttctca     5040

cccgtttgaa tctttaccta cacattactc aggcattgca tttaaaatat atgagggttc     5100

taaaaatttt tatccttgcg ttgaaataaa ggcttctccc gcaaaagtat tacagggtca     5160

taatgttttt ggtacaaccg atttagcttt atgctctgag gctttattgc ttaattttgc     5220

taattctttg ccttgcctgt atgatttatt ggatgttgga atcgcctgat gcggtatttt     5280

ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag tacaatctgc     5340

tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga     5400

cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc     5460

atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata     5520

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     5580

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     5640

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     5700

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     5760

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     5820

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     5880

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     5940

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     6000

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     6060

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     6120

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     6180

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     6240

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     6300

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     6360

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     6420

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     6480

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     6540

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     6600

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     6660

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     6720

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     6780

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     6840

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     6900

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     6960

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     7020

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     7080

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     7140

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     7200

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     7260

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     7320

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     7380

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     7440

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     7500

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atg            7553


<210>  45
<211>  7252
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  45
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagcctt      660

gccttgacca atagccttga caaggcaaac ttgaccaata gtcttagagt atccagtgag      720

gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctt cagcagttcc      780

acccgcggga acagagaaac aggagaatat gggccaaaca ggatatctgt ggtaagcagt      840

tcctgccccg gctcagggcc aagaacagtt ggaacagcag aatatgggcc aaacaggata      900

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg      960

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     1020

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     1080

gcttctgctc cccgagctct atataagcag agctcgttta gtgaaccgtc agatcgcctg     1140

gagacgccat ccacgctgtt ttgacttcca tagaaggcgg ccgcgccgcc accatggtga     1200

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     1260

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     1320

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     1380

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     1440

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     1500

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     1560

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     1620

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     1680

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     1740

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     1800

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     1860

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag taacctgcag     1920

ggataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     1980

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     2040

ccgtatggct ttcattttct cctccttgta taaatcctgg ttagttcttg ccacggcgga     2100

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     2160

ttccgtggtg tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattctagc     2220

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa     2280

caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga gatgtgggag     2340

gttttttaaa gcgaattctc tggaacctat cagggaccac agtcagccag gcaagcacat     2400

ctgcccaagc caagggtgga ggcatgcagc tgtgggggtc tgtgaaaaca cttgagggag     2460

cagataactg ggccaaccat gactcagtgc ttctggaggc caacaggact gctgagtcat     2520

cctgtggggg tggaggtggg acaagggaaa ggggtgaatg gtactgctga ttacaacctc     2580

tggtgctgcc tccccctcct gtttatctga gaggctagcg taaatacact tgcaaaggag     2640

gatgttttta gtagcaattt gtactgatgg tatggggcca agagatatat cttagaggga     2700

gggctgaggg tttgaagtcc aactcctaag ccagtgccag aagagccaag gacaggtacg     2760

gctgtcatca cttagacctc accctgtgga gccacaccct agggttggcc aatctactcc     2820

caggagcagg gagggcagga gccagggctg ggcataaaag tcagggcaga gccatctatt     2880

gcttacactc gcttctggaa cgtctgaggt tatcaataag ctcctagtcc agacgccatg     2940

ggtcatttca cagaggagga caaggctact atcacaagcc tgtggggcaa ggtgaatgtg     3000

gaagatgctg gaggagaaac cctgggaagg taggctctgg tgaccaggac aagggaggga     3060

aggaaggacc ctgtgcctgg caaaagtcca ggtcgcttct caggatttgt ggcaccttct     3120

gactgtcaaa ctgttcttgt caatctcaca ggctcctggt tgtctaccca tggacccaga     3180

ggttctttga cagctttggc aacctgtcct ctgcctctgc catcatgggc aaccccaaag     3240

tcaaggcaca tggcaagaag gtgctgactt ccttgggaga tgccacaaag cacctggatg     3300

atctcaaggg cacctttgcc cagctgagtg aactgcactg tgacaagctg catgtggatc     3360

ctgagaactt caaggtgagt ccaggagatg tttcagccct gttgccttta gtctcgaggc     3420

aacttagaca acggagtatt gatctgagca cagcagggtg tgagctgttt gaagatactg     3480

gggtctcgag gtcgacgtag ataagtagca tggcgggtta atcattaact acaaggaacc     3540

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     3600

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     3660

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     3720

tgaatggcga atggcgattc cgttgcaatg gctggcggta atattgttct ggatattacc     3780

agcaaggccg atagtttgag ttcttctact caggcaagtg atgttattac taatcaaaga     3840

agtattgcga caacggttaa tttgcgtgat ggacagactc ttttactcgg tggcctcact     3900

gattataaaa acacttctca ggattctggc gtaccgttcc tgtctaaaat ccctttaatc     3960

ggcctcctgt ttagctcccg ctctgattct aacgaggaaa gcacgttata cgtgctcgtc     4020

aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     4080

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     4140

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     4200

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     4260

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     4320

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     4380

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     4440

ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt aaatatttgc     4500

ttatacaatc ttcctgtttt tggggctttt ctgattatca accggggtac atatgattga     4560

catgctagtt ttacgattac cgttcatcga ttctcttgtt tgctccagac tctcaggcaa     4620

tgacctgata gcctttgtag agacctctca aaaatagcta ccctctccgg catgaattta     4680

tcagctagaa cggttgaata tcatattgat ggtgatttga ctgtctccgg cctttctcac     4740

ccgtttgaat ctttacctac acattactca ggcattgcat ttaaaatata tgagggttct     4800

aaaaattttt atccttgcgt tgaaataaag gcttctcccg caaaagtatt acagggtcat     4860

aatgtttttg gtacaaccga tttagcttta tgctctgagg ctttattgct taattttgct     4920

aattctttgc cttgcctgta tgatttattg gatgttggaa tcgcctgatg cggtattttc     4980

tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct     5040

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     5100

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     5160

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     5220

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt     5280

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     5340

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta     5400

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg     5460

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac     5520

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg     5580

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc     5640

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg     5700

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat     5760

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg     5820

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg     5880

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc     5940

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt     6000

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct     6060

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc     6120

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca     6180

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct     6240

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     6300

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     6360

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     6420

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     6480

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     6540

taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag     6600

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     6660

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     6720

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     6780

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     6840

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     6900

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     6960

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     7020

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     7080

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     7140

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     7200

agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tg             7252


<210>  46
<211>  6991
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  46
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagcctt      660

gccttgacca atagccttga caaggcaaac ttgaccaata gtcttagagt atccagtgag      720

gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctt cagcagttcc      780

acccgcggga acagagaaac aggagaatat gggccaaaca ggatatctgt ggtaagcagt      840

tcctgccccg gctcagggcc aagaacagtt ggaacagcag aatatgggcc aaacaggata      900

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg      960

tcccgccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     1020

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     1080

gcttctgctc cccgagctct atataagcag agctcgttta gtgaaccgtc agatcgcctg     1140

gagacgccat ccacgctgtt ttgacttcca tagaaggcgg ccgcgccgcc accatggtga     1200

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     1260

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     1320

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     1380

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     1440

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     1500

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     1560

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     1620

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     1680

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     1740

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     1800

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     1860

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag taacctgcag     1920

ggataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     1980

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     2040

ccgtatggct ttcattttct cctccttgta taaatcctgg ttagttcttg ccacggcgga     2100

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     2160

ttccgtggtg tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattctagc     2220

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa     2280

caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga gatgtgggag     2340

gttttttaaa gcgaattcgt aaatacactt gcaaaggagg atgtttttag tagcaatttg     2400

tactgatggt atggggccaa gagatatatc ttagagggag ggctgagggt ttgaagtcca     2460

actcctaagc cagtgccaga agagccaagg acaggtacgg ctgtcatcac ttagacctca     2520

ccctgtggag ccacacccta gggttggcca atctactccc aggagcaggg agggcaggag     2580

ccagggctgg gcataaaagt cagggcagag ccatctattg cttacactcg cttctggaac     2640

gtctgaggtt atcaataagc tcctagtcca gacgccatgg gtcatttcac agaggaggac     2700

aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg aggagaaacc     2760

ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc tgtgcctggc     2820

aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac tgttcttgtc     2880

aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac agctttggca     2940

acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat ggcaagaagg     3000

tgctgacttc cttgggagat gccacaaagc acctggatga tctcaagggc acctttgccc     3060

agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc aaggtgagtc     3120

caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa cggagtattg     3180

atctgagcac agcagggtgt gagctgtttg aagatactgg ggtctcgagg tcgacgtaga     3240

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     3300

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     3360

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag     3420

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc     3480

gttgcaatgg ctggcggtaa tattgttctg gatattacca gcaaggccga tagtttgagt     3540

tcttctactc aggcaagtga tgttattact aatcaaagaa gtattgcgac aacggttaat     3600

ttgcgtgatg gacagactct tttactcggt ggcctcactg attataaaaa cacttctcag     3660

gattctggcg taccgttcct gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc     3720

tctgattcta acgaggaaag cacgttatac gtgctcgtca aagcaaccat agtacgcgcc     3780

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     3840

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     3900

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     3960

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     4020

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     4080

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     4140

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     4200

ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct tcctgttttt     4260

ggggcttttc tgattatcaa ccggggtaca tatgattgac atgctagttt tacgattacc     4320

gttcatcgat tctcttgttt gctccagact ctcaggcaat gacctgatag cctttgtaga     4380

gacctctcaa aaatagctac cctctccggc atgaatttat cagctagaac ggttgaatat     4440

catattgatg gtgatttgac tgtctccggc ctttctcacc cgtttgaatc tttacctaca     4500

cattactcag gcattgcatt taaaatatat gagggttcta aaaattttta tccttgcgtt     4560

gaaataaagg cttctcccgc aaaagtatta cagggtcata atgtttttgg tacaaccgat     4620

ttagctttat gctctgaggc tttattgctt aattttgcta attctttgcc ttgcctgtat     4680

gatttattgg atgttggaat cgcctgatgc ggtattttct ccttacgcat ctgtgcggta     4740

tttcacaccg catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc     4800

agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     4860

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     4920

catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     4980

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     5040

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     5100

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     5160

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     5220

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     5280

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     5340

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc     5400

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     5460

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5520

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     5580

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     5640

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt     5700

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     5760

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     5820

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     5880

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     5940

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     6000

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     6060

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     6120

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     6180

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     6240

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     6300

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     6360

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     6420

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     6480

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     6540

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     6600

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     6660

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     6720

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     6780

tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg     6840

attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa     6900

cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc     6960

ctctccccgc gcgttggccg attcattaat g                                    6991


<210>  47
<211>  7825
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  47
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccgcgggaa cagagaaaca      660

ggagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca      720

agaacagttg gaacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc      780

cccggctcag ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta      840

gagaaccatc agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt      900

gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcta      960

tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt     1020

tgacttccat agaaggcggc cgcgccgcca ccatggtgag caagggcgag gagctgttca     1080

ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg     1140

tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca     1200

ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc     1260

agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc     1320

ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc     1380

gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg     1440

acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca     1500

acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc     1560

acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg     1620

gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca     1680

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga     1740

tcactctcgg catggacgag ctgtacaagt aacctgcagg gataatcaac ctctggatta     1800

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     1860

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     1920

ctccttgtat aaatcctggt tagttcttgc cacggcggaa ctcatcgccg cctgccttgc     1980

ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt ttatttgtga     2040

aatttgtgat gctattgctt tatttgtaac cattctagct ttatttgtga aatttgtgat     2100

gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc     2160

attcatttta tgtttcaggt tcagggggag atgtgggagg ttttttaaag cgaattccga     2220

gatcgagacc atcctggcta acacagtgaa accccgtctc tactaaaaaa atacaaaaaa     2280

ttagccgggc ttggtggcgg gtgcctgtag tcccagctac tatggaggct gaggcgggag     2340

aatggcgtga acgcgggggg cggagcttgc agtgagcaga gatcaggggc cactgcactc     2400

cagcctgggc gacagagaga gactctgtct caaaaaaaag aaaaaaaaaa tttagtagac     2460

tagctaaaaa aatccagaga tagttattga tgcatatgta aaagtcttcc aatatttaca     2520

agtacaatga aaaaaaaata accttgaatt aagtgtagaa ctcattgaca atgtttcaaa     2580

ggatgtgagg gataaactaa aatttgggca gtacatgctg ttcctgtgta cttggaacag     2640

agggagaaaa tctgggctgg aaatattgtt ataggagtta gcacatgaag gtgacaacta     2700

aattatttgg agtagatgga gtcaccagca catgtgaata gttttagaat gaaatgaccc     2760

aagatagaac tttggagagc ccccaaattt aaataaaatc agtataagag aagaggaaga     2820

aaccaaatgg tatactagtc taaattgttt cttagtgaca aaagaataac ctgaatatta     2880

gattagctgc ctatatgctc tctgaatcaa tttcattcaa catgcaacag ttctggaacc     2940

tatcagggac cacagtcagc caggcaagca catctgccca agccaagggt ggaggcatgc     3000

agctgtgggg gtctgtgaaa acacttgagg gagcagataa ctgggccaac catgactcag     3060

tgcttctgga ggccaacagg actgctgagt catcctgtgg gggtggaggt gggacaaggg     3120

aaaggggtga atggtactgc tgattacaac ctctggtgct gcctccccct cctgtttatc     3180

tgagaggcta gcgtaaatac acttgcaaag gaggatgttt ttagtagcaa tttgtactga     3240

tggtatgggg ccaagagata tatcttagag ggagggctga gggtttgaag tccaactcct     3300

aagccagtgc cagaagagcc aaggacaggt acggctgtca tcacttagac ctcaccctgt     3360

ggagccacac cctagggttg gccaatctac tcccaggagc agggagggca ggagccaggg     3420

ctgggcataa aagtcagggc agagccatct attgcttaca ctcgcttctg gaacgtctga     3480

ggttatcaat aagctcctag tccagacgcc atgggtcatt tcacagagga ggacaaggct     3540

actatcacaa gcctgtgggg caaggtgaat gtggaagatg ctggaggaga aaccctggga     3600

aggtaggctc tggtgaccag gacaagggag ggaaggaagg accctgtgcc tggcaaaagt     3660

ccaggtcgct tctcaggatt tgtggcacct tctgactgtc aaactgttct tgtcaatctc     3720

acaggctcct ggttgtctac ccatggaccc agaggttctt tgacagcttt ggcaacctgt     3780

cctctgcctc tgccatcatg ggcaacccca aagtcaaggc acatggcaag aaggtgctga     3840

cttccttggg agatgccaca aagcacctgg atgatctcaa gggcaccttt gcccagctga     3900

gtgaactgca ctgtgacaag ctgcatgtgg atcctgagaa cttcaaggtg agtccaggag     3960

atgtttcagc cctgttgcct ttagtctcga ggcaacttag acaacggagt attgatctga     4020

gcacagcagg gtgtgagctg tttgaagata ctggggtctc gaggtcgacg tagataagta     4080

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4140

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4200

tgcccgggcg gcctcagtga gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc     4260

gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcga ttccgttgca     4320

atggctggcg gtaatattgt tctggatatt accagcaagg ccgatagttt gagttcttct     4380

actcaggcaa gtgatgttat tactaatcaa agaagtattg cgacaacggt taatttgcgt     4440

gatggacaga ctcttttact cggtggcctc actgattata aaaacacttc tcaggattct     4500

ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc tgtttagctc ccgctctgat     4560

tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag     4620

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     4680

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     4740

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     4800

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     4860

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     4920

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     4980

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     5040

caaaatatta acgtttacaa tttaaatatt tgcttataca atcttcctgt ttttggggct     5100

tttctgatta tcaaccgggg tacatatgat tgacatgcta gttttacgat taccgttcat     5160

cgattctctt gtttgctcca gactctcagg caatgacctg atagcctttg tagagacctc     5220

tcaaaaatag ctaccctctc cggcatgaat ttatcagcta gaacggttga atatcatatt     5280

gatggtgatt tgactgtctc cggcctttct cacccgtttg aatctttacc tacacattac     5340

tcaggcattg catttaaaat atatgagggt tctaaaaatt tttatccttg cgttgaaata     5400

aaggcttctc ccgcaaaagt attacagggt cataatgttt ttggtacaac cgatttagct     5460

ttatgctctg aggctttatt gcttaatttt gctaattctt tgccttgcct gtatgattta     5520

ttggatgttg gaatcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     5580

accgcatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc     5640

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     5700

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     5760

cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga     5820

taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta     5880

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat     5940

aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc     6000

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga     6060

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca     6120

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt     6180

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     6240

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     6300

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     6360

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     6420

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     6480

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     6540

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     6600

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     6660

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     6720

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     6780

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     6840

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     6900

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     6960

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     7020

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     7080

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     7140

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     7200

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     7260

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     7320

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     7380

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     7440

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     7500

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     7560

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     7620

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     7680

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     7740

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     7800

ccgcgcgttg gccgattcat taatg                                           7825


<210>  48
<211>  7111
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  48
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

ctagaaattg ttttcactgc actattgaga aattaagaga taatggcaaa agtcacaaag      240

agtatattca aaaagaagta tagcactttt tccttagaaa ccactgctaa ctgaaagaga      300

ctaagatttg tcccgtcaaa aatcctggac ctatgcctaa aacacatttc acaatccctg      360

aacttttcaa aaattggtac atgctttagc tttaaactac aggcctcact ggagctagag      420

acaagaaggt aaaaaacggc tgacaaaaga agtcctggta tcctctatga tgggagaagg      480

aaactagcta aagggaagaa taaattagag aaaaactgga atgactgaat cggaacaagg      540

caaaggctat aaaaaaaatt agcagtatcc tcttgggggc cccttcccca cactatctca      600

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccgcgggaa cagagaaaca      660

ggagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca      720

agaacagttg gaacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc      780

cccggctcag ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta      840

gagaaccatc agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt      900

gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcta      960

tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt     1020

tgacttccat agaaggcggc cgcgccgcca ccatggtgag caagggcgag gagctgttca     1080

ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg     1140

tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca     1200

ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc     1260

agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc     1320

ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc     1380

gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg     1440

acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca     1500

acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc     1560

acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg     1620

gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca     1680

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga     1740

tcactctcgg catggacgag ctgtacaagt aacctgcagg gataatcaac ctctggatta     1800

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     1860

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     1920

ctccttgtat aaatcctggt tagttcttgc cacggcggaa ctcatcgccg cctgccttgc     1980

ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt ttatttgtga     2040

aatttgtgat gctattgctt tatttgtaac cattctagct ttatttgtga aatttgtgat     2100

gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc     2160

attcatttta tgtttcaggt tcagggggag atgtgggagg ttttttaaag cgaattctct     2220

ggaacctatc agggaccaca gtcagccagg caagcacatc tgcccaagcc aagggtggag     2280

gcatgcagct gtgggggtct gtgaaaacac ttgagggagc agataactgg gccaaccatg     2340

actcagtgct tctggaggcc aacaggactg ctgagtcatc ctgtgggggt ggaggtggga     2400

caagggaaag gggtgaatgg tactgctgat tacaacctct ggtgctgcct ccccctcctg     2460

tttatctgag aggctagcgt aaatacactt gcaaaggagg atgtttttag tagcaatttg     2520

tactgatggt atggggccaa gagatatatc ttagagggag ggctgagggt ttgaagtcca     2580

actcctaagc cagtgccaga agagccaagg acaggtacgg ctgtcatcac ttagacctca     2640

ccctgtggag ccacacccta gggttggcca atctactccc aggagcaggg agggcaggag     2700

ccagggctgg gcataaaagt cagggcagag ccatctattg cttacactcg cttctggaac     2760

gtctgaggtt atcaataagc tcctagtcca gacgccatgg gtcatttcac agaggaggac     2820

aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg aggagaaacc     2880

ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc tgtgcctggc     2940

aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac tgttcttgtc     3000

aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac agctttggca     3060

acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat ggcaagaagg     3120

tgctgacttc cttgggagat gccacaaagc acctggatga tctcaagggc acctttgccc     3180

agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc aaggtgagtc     3240

caggagatgt ttcagccctg ttgcctttag tctcgaggca acttagacaa cggagtattg     3300

atctgagcac agcagggtgt gagctgtttg aagatactgg ggtctcgagg tcgacgtaga     3360

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     3420

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     3480

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag     3540

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc     3600

gttgcaatgg ctggcggtaa tattgttctg gatattacca gcaaggccga tagtttgagt     3660

tcttctactc aggcaagtga tgttattact aatcaaagaa gtattgcgac aacggttaat     3720

ttgcgtgatg gacagactct tttactcggt ggcctcactg attataaaaa cacttctcag     3780

gattctggcg taccgttcct gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc     3840

tctgattcta acgaggaaag cacgttatac gtgctcgtca aagcaaccat agtacgcgcc     3900

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     3960

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     4020

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     4080

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     4140

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     4200

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     4260

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     4320

ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct tcctgttttt     4380

ggggcttttc tgattatcaa ccggggtaca tatgattgac atgctagttt tacgattacc     4440

gttcatcgat tctcttgttt gctccagact ctcaggcaat gacctgatag cctttgtaga     4500

gacctctcaa aaatagctac cctctccggc atgaatttat cagctagaac ggttgaatat     4560

catattgatg gtgatttgac tgtctccggc ctttctcacc cgtttgaatc tttacctaca     4620

cattactcag gcattgcatt taaaatatat gagggttcta aaaattttta tccttgcgtt     4680

gaaataaagg cttctcccgc aaaagtatta cagggtcata atgtttttgg tacaaccgat     4740

ttagctttat gctctgaggc tttattgctt aattttgcta attctttgcc ttgcctgtat     4800

gatttattgg atgttggaat cgcctgatgc ggtattttct ccttacgcat ctgtgcggta     4860

tttcacaccg catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc     4920

agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     4980

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     5040

catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     5100

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     5160

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     5220

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     5280

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     5340

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     5400

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     5460

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc     5520

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     5580

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5640

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     5700

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     5760

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt     5820

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     5880

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     5940

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     6000

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     6060

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     6120

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     6180

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     6240

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     6300

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     6360

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     6420

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     6480

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     6540

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     6600

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     6660

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     6720

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     6780

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     6840

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     6900

tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg     6960

attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa     7020

cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc     7080

ctctccccgc gcgttggccg attcattaat g                                    7111


<210>  49
<211>  8293
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  49
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgt atacatacat acctgaatat ggaatcaaat      180

atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg      240

aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc      300

tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca      360

aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag      420

agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc      480

ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta      540

gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga      600

aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca      660

aggcaaaggc tataaaaaaa attaagcagc agtatcctct tgggggcccc ttccccacac      720

tatctcaatg caaatatctg tctgaaacgg tccctggcta aactccaccc atgggttggc      780

cagccttgcc ttgacgctag cgtaaataca cttgcaaagg aggatgtttt tagtagcaat      840

ttgtactgat ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt      900

ccaactccta agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc      960

tcaccctgtg gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag     1020

gagccagggc tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga     1080

cacaactgtg ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag     1140

aagtctgccg ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc     1200

ctgggcaggt tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca     1260

tgtggagaca gagaagactc ttgggtttct gataggcact gactctctct gcctattggt     1320

ctattttccc acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc     1380

ctttggggat ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg     1440

caagaaagtg ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac     1500

ctttgcccag ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag     1560

ggtgagtcta tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg     1620

tcataggaag gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat     1680

ttgtaatttt aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa     1740

tactttccct aatctctttc tttcagggca ataatgatac aatgtatcat gcctctttgc     1800

accattctaa agaataacag tgataatttc tgggttaagg caatagcaat atttctgcat     1860

ataaatattt ctgcatataa attgtaactg atgtaagagg tttcatattg ctaatagcag     1920

ctacaatcca gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg     1980

agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacagctc     2040

ctgggcaacg tgctggtctg tgtgctggcc catcactttg gcaaagaatt caccccacca     2100

gtgcaggctg cctatcagaa agtggtggct ggtgtggcta atgccctggc ccacaagtat     2160

cactaagctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc     2220

aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa     2280

aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt actaaaaagg     2340

gaatgtggga ggttgcagtg ctagtctccc ggaactatca ctctttcaca gtctgctttg     2400

gaaggactgg gcttagtatg aaaagttagg actgagaaga atttgaaagg gggctttttg     2460

tagcttgata ttcactactg tcttattacc ctatcatagg cccaccccaa atggaagtcc     2520

cattcttcct caggatgttt aagattagca ttcaggaaga gatcagaggt ctgctggctc     2580

ccttatcatg tcccttatgg tgcttctggc tctgcaccgc ggccacgggg ttggggttgc     2640

gccttttcca aggcagccct gggtttgcgc agggacgcgg ctgctctggg cgtggttccg     2700

ggaaacgcag cggcgccgac cctgggtctc gcacattctt cacgtccgtt cgcagcgtca     2760

cccggatctt cgccgctacc cttgtgggcc ccccggcgac gcttcctgct ccgcccctaa     2820

gtcgggaagg ttccttgcgg ttcgcggcgt gccggacgtg acaaacggaa gccgcacgtc     2880

tcactagtac cctcgcagac ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat     2940

gggctgtggc caatagcggc tgctcagcgg ggcgcgccga gagcagcggc cgggaagggg     3000

cggtgcggga ggcggggtgt ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt     3060

ccgcattctg caagcctccg gagcgcacgt cggcagtcgg ctccctcgtt gaccgaatca     3120

ccgacctctc tccccagcgg ccgcgccgcc accatggaca aggattgtga aatgaaacgc     3180

accacactgg acagcccttt ggggaagctg gagctgtctg gttgtgagca gggtctgcac     3240

gaaataaagc tcctgggcaa ggggacgtct gcagctgatg ccgtggaggt cccagccccc     3300

gctgcggttc tcggaggtcc ggagcccctg atgcagtgca cagcctggct gaatgcctat     3360

ttccaccagc ccgaggctat cgaagagttc cccgtgccgg ctcttcacca tcccgttttc     3420

cagcaagagt cgttcaccag acaggtgtta tggaagctgc tgaaggttgt gaaattcgga     3480

gaagtgattt cttaccagca attagcagcc ctggcaggca accccaaagc cgcgcgagca     3540

gtgggaggag caatgagagg caatcctgtc aaaatcctca tcccgtgcca cagagtggtc     3600

tgcagcagcg gagccgtggg caactactcc ggaggactgg ccgtgaagga atggcttctg     3660

gcccatgaag gccaccggtt ggggaagcca ggcttgggag ggagctcagg tctggcaggg     3720

gcctggctca agggagcggg agctacctcg ggctccccgc ctgctggccg aaactaagct     3780

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     3840

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg     3900

ttttttaaag ccctgcaggc aatagccttg acaaggcaaa cttgaccaat agtcttagag     3960

tatccagtga ggccaggggc cggcggctgg ctagggatga agaataaaag gaagcaccct     4020

tcagcagttc cacacactcg cttctggaac gtctgaggtt atcaataagc tcctagtcca     4080

gacgccatgg gtcatttcac agaggaggac aaggctacta tcacaagcct gtggggcaag     4140

gtgaatgtgg aagatgctgg aggagaaacc ctgggaaggt aggctctggt gaccaggaca     4200

agggagggaa ggaaggaccc tgtgcctggc aaaagtccag gtcgcttctc aggatttgtg     4260

gcaccttctg actgtcaaac tgttcttgtc aatctcacag gctcctggtt gtctacccat     4320

ggacccagag gttctttgac agctttggca acctgtcctc tgcctctgcc atcatgggca     4380

accccaaagt caaggcacat ggcaagaagg tgctgacttc cttgggagat gccacaaagc     4440

acctggatga tctcaagggc acctttgccc agctgagtga actgcactgt gacaagctgc     4500

atgtggatcc tgagaacttc aaggtgagtc caggagatgt ttcagccctg ttgcctttag     4560

tctcgaggcg tcgacaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     4620

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     4680

cctcagtgag cgagcgagcg cgcagctggc gtaatagcga agaggcccgc accgatcgcc     4740

cttcccaaca gttgcgcagc ctgaatggcg aatggcgatt ccgttgcaat ggctggcggt     4800

aatattgttc tggatattac cagcaaggcc gatagtttga gttcttctac tcaggcaagt     4860

gatgttatta ctaatcaaag aagtattgcg acaacggtta atttgcgtga tggacagact     4920

cttttactcg gtggcctcac tgattataaa aacacttctc aggattctgg cgtaccgttc     4980

ctgtctaaaa tccctttaat cggcctcctg tttagctccc gctctgattc taacgaggaa     5040

agcacgttat acgtgctcgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag     5100

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     5160

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     5220

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     5280

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     5340

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     5400

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     5460

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac     5520

gtttacaatt taaatatttg cttatacaat cttcctgttt ttggggcttt tctgattatc     5580

aaccggggta catatgattg acatgctagt tttacgatta ccgttcatcg attctcttgt     5640

ttgctccaga ctctcaggca atgacctgat agcctttgta gagacctctc aaaaatagct     5700

accctctccg gcatgaattt atcagctaga acggttgaat atcatattga tggtgatttg     5760

actgtctccg gcctttctca cccgtttgaa tctttaccta cacattactc aggcattgca     5820

tttaaaatat atgagggttc taaaaatttt tatccttgcg ttgaaataaa ggcttctccc     5880

gcaaaagtat tacagggtca taatgttttt ggtacaaccg atttagcttt atgctctgag     5940

gctttattgc ttaattttgc taattctttg ccttgcctgt atgatttatt ggatgttgga     6000

atcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt     6060

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     6120

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     6180

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     6240

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     6300

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     6360

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     6420

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     6480

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     6540

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     6600

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     6660

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     6720

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     6780

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     6840

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     6900

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     6960

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     7020

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     7080

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     7140

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     7200

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     7260

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     7320

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     7380

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     7440

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     7500

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     7560

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     7620

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     7680

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     7740

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     7800

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     7860

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     7920

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     7980

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     8040

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     8100

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     8160

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     8220

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     8280

cgattcatta atg                                                        8293


<210>  50
<211>  8290
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  50
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctgtggc tttatagaaa ttgttttcac tgcactattg      180

agaaattaag agataatggc aaaagtcaca aagagtatat tcaaaaagaa gtatagcact      240

ttttccttag aaaccactgc taactgaaag agactaagat ttgtcccgtc aaaaatcctg      300

gacctatgcc taaaacacat ttcacaatcc ctgaactttt caaaaattgg tacatgcttt      360

agctttaaac tacaggcctc actggagcta gagacaagaa ggtaaaaaac ggctgacaaa      420

agaagtcctg gtatcctcta tgatgggaga aggaaactag ctaaagggaa gaataaatta      480

gagaaaaact ggaatgactg aatcggaaca aggcaaaggc tataaaaaaa attaagcagc      540

agtatcctct tgggggcccc ttccccacac tatctcaatg caaatatctg tctgaaacgg      600

tccctggcta aactccaccc atgggttggc cagccttgcc ttgacgctag cgtaaataca      660

cttgcaaagg aggatgtttt tagtagcaat ttgtactgat ggtatggggc caagagatat      720

atcttagagg gagggctgag ggtttgaagt ccaactccta agccagtgcc agaagagcca      780

aggacaggta cggctgtcat cacttagacc tcaccctgtg gagccacacc ctagggttgg      840

ccaatctact cccaggagca gggagggcag gagccagggc tgggcataaa agtcagggca      900

gagccatcta ttgcttacat ttgcttctga cacaactgtg ttcactagca acctcaaaca      960

gacaccatgg tgcacctgac tcctgaggag aagtctgccg ttactgccct gtggggcaag     1020

gtgaacgtgg atgaagttgg tggtgaggcc ctgggcaggt tggtatcaag gttacaagac     1080

aggtttaagg agaccaatag aaactgggca tgtggagaca gagaagactc ttgggtttct     1140

gataggcact gactctctct gcctattggt ctattttccc acccttaggc tgctggtggt     1200

ctacccttgg acccagaggt tctttgagtc ctttggggat ctgtccactc ctgatgctgt     1260

tatgggcaac cctaaggtga aggctcatgg caagaaagtg ctcggtgcct ttagtgatgg     1320

cctggctcac ctggacaacc tcaagggcac ctttgcccag ctgagtgagc tgcactgtga     1380

caagctgcac gtggatcctg agaacttcag ggtgagtcta tgggaccctt gatgttttct     1440

ttccccttct tttctatggt taagttcatg tcataggaag gggagaagta acagggtaca     1500

catattgacc aaatcagggt aattttgcat ttgtaatttt aaaaaatgct ttcttctttt     1560

aatatacttt tttgtttatc ttatttctaa tactttccct aatctctttc tttcagggca     1620

ataatgatac aatgtatcat gcctctttgc accattctaa agaataacag tgataatttc     1680

tgggttaagg caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg     1740

atgtaagagg tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt     1800

ttatggttgg gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg     1860

ttcatacctc ttatcttcct cccacagctc ctgggcaacg tgctggtctg tgtgctggcc     1920

catcactttg gcaaagaatt caccccacca gtgcaggctg cctatcagaa agtggtggct     1980

ggtgtggcta atgccctggc ccacaagtat cactaagctc gctttcttgc tgtccaattt     2040

ctattaaagg ttcctttgtt ccctaagtcc aactactaaa ctgggggata ttatgaaggg     2100

ccttgagcat ctggattctg cctaataaaa aacatttatt ttcattgcaa tgatgtattt     2160

aaattatttc tgaatatttt actaaaaagg gaatgtggga ggttgcagtg ctagtctccc     2220

ggaactatca ctctttcaca gtctgctttg gaaggactgg gcttagtatg aaaagttagg     2280

actgagaaga atttgaaagg gggctttttg tagcttgata ttcactactg tcttattacc     2340

ctatcatagg cccaccccaa atggaagtcc cattcttcct caggatgttt aagattagca     2400

ttcaggaaga gatcagaggt ctgctggctc ccttatcatg tcccttatgg tgcttctggc     2460

tctgcaccgc ggccacgggg ttggggttgc gccttttcca aggcagccct gggtttgcgc     2520

agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac cctgggtctc     2580

gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc cttgtgggcc     2640

ccccggcgac gcttcctgct ccgcccctaa gtcgggaagg ttccttgcgg ttcgcggcgt     2700

gccggacgtg acaaacggaa gccgcacgtc tcactagtac cctcgcagac ggacagcgcc     2760

agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc tgctcagcgg     2820

ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt ggggcggtag     2880

tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg gagcgcacgt     2940

cggcagtcgg ctccctcgtt gaccgaatca ccgacctctc tccccagcgg ccgcgccgcc     3000

accatggaca aggattgtga aatgaaacgc accacactgg acagcccttt ggggaagctg     3060

gagctgtctg gttgtgagca gggtctgcac gaaataaagc tcctgggcaa ggggacgtct     3120

gcagctgatg ccgtggaggt cccagccccc gctgcggttc tcggaggtcc ggagcccctg     3180

atgcagtgca cagcctggct gaatgcctat ttccaccagc ccgaggctat cgaagagttc     3240

cccgtgccgg ctcttcacca tcccgttttc cagcaagagt cgttcaccag acaggtgtta     3300

tggaagctgc tgaaggttgt gaaattcgga gaagtgattt cttaccagca attagcagcc     3360

ctggcaggca accccaaagc cgcgcgagca gtgggaggag caatgagagg caatcctgtc     3420

aaaatcctca tcccgtgcca cagagtggtc tgcagcagcg gagccgtggg caactactcc     3480

ggaggactgg ccgtgaagga atggcttctg gcccatgaag gccaccggtt ggggaagcca     3540

ggcttgggag ggagctcagg tctggcaggg gcctggctca agggagcggg agctacctcg     3600

ggctccccgc ctgctggccg aaactaagat aatcaacctc tggattacaa aatttgtgaa     3660

agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta     3720

atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa     3780

tcctggttag ttcttgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca     3840

ggggctcggc tgttgggcac tgacaattcc gtggtgttta tttgtgaaat ttgtgatgct     3900

attgctttat ttgtaaccat tctagcttta tttgtgaaat ttgtgatgct attgctttat     3960

ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt     4020

ttcaggttca gggggagatg tgggaggttt tttaaagccc tgcaggcaat agccttgaca     4080

aggcaaactt gaccaatagt cttagagtat ccagtgaggc caggggccgg cggctggcta     4140

gggatgaaga ataaaaggaa gcacccttca gcagttccac acactcgctt ctggaacgtc     4200

tgaggttatc aataagctcc tagtccagac gccatgggtc atttcacaga ggaggacaag     4260

gctactatca caagcctgtg gggcaaggtg aatgtggaag atgctggagg agaaaccctg     4320

ggaaggtagg ctctggtgac caggacaagg gagggaagga aggaccctgt gcctggcaaa     4380

agtccaggtc gcttctcagg atttgtggca ccttctgact gtcaaactgt tcttgtcaat     4440

ctcacaggct cctggttgtc tacccatgga cccagaggtt ctttgacagc tttggcaacc     4500

tgtcctctgc ctctgccatc atgggcaacc ccaaagtcaa ggcacatggc aagaaggtgc     4560

tgacttgtcg acaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4620

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4680

cagtgagcga gcgagcgcgc agctggcgta atagcgaaga ggcccgcacc gatcgccctt     4740

cccaacagtt gcgcagcctg aatggcgaat ggcgattccg ttgcaatggc tggcggtaat     4800

attgttctgg atattaccag caaggccgat agtttgagtt cttctactca ggcaagtgat     4860

gttattacta atcaaagaag tattgcgaca acggttaatt tgcgtgatgg acagactctt     4920

ttactcggtg gcctcactga ttataaaaac acttctcagg attctggcgt accgttcctg     4980

tctaaaatcc ctttaatcgg cctcctgttt agctcccgct ctgattctaa cgaggaaagc     5040

acgttatacg tgctcgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc     5100

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     5160

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     5220

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     5280

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     5340

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     5400

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg     5460

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt     5520

tacaatttaa atatttgctt atacaatctt cctgtttttg gggcttttct gattatcaac     5580

cggggtacat atgattgaca tgctagtttt acgattaccg ttcatcgatt ctcttgtttg     5640

ctccagactc tcaggcaatg acctgatagc ctttgtagag acctctcaaa aatagctacc     5700

ctctccggca tgaatttatc agctagaacg gttgaatatc atattgatgg tgatttgact     5760

gtctccggcc tttctcaccc gtttgaatct ttacctacac attactcagg cattgcattt     5820

aaaatatatg agggttctaa aaatttttat ccttgcgttg aaataaaggc ttctcccgca     5880

aaagtattac agggtcataa tgtttttggt acaaccgatt tagctttatg ctctgaggct     5940

ttattgctta attttgctaa ttctttgcct tgcctgtatg atttattgga tgttggaatc     6000

gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca     6060

ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac     6120

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     6180

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     6240

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     6300

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     6360

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     6420

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     6480

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     6540

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     6600

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     6660

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     6720

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     6780

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     6840

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     6900

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     6960

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     7020

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg     7080

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     7140

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     7200

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     7260

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat     7320

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc     7380

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     7440

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     7500

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     7560

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc     7620

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     7680

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     7740

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     7800

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     7860

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     7920

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata     7980

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     8040

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     8100

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta     8160

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag     8220

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga     8280

ttcattaatg                                                            8290


<210>  51
<211>  8222
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  51
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgt atacatacat acctgaatat ggaatcaaat      180

atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg      240

aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc      300

tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca      360

aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag      420

agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc      480

ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta      540

gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga      600

aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca      660

aggcaaaggc tataaaaaaa attaagcagc agtatcctct tgggggcccc ttccccacac      720

tatctcaatg caaatatctg tctgaaacgg tccctggcta aactccaccc atgggttggc      780

cagccttgcc ttgacgctag cgtaaataca cttgcaaagg aggatgtttt tagtagcaat      840

ttgtactgat ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt      900

ccaactccta agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc      960

tcaccctgtg gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag     1020

gagccagggc tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga     1080

cacaactgtg ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag     1140

aagtctgccg ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc     1200

ctgggcaggt tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca     1260

tgtggagaca gagaagactc ttgggtttct gataggcact gactctctct gcctattggt     1320

ctattttccc acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc     1380

ctttggggat ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg     1440

caagaaagtg ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac     1500

ctttgcccag ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag     1560

ggtgagtcta tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg     1620

tcataggaag gggagaagta acagggtaca catattgacc aaatcagggt aattttgcat     1680

ttgtaatttt aaaaaatgct ttcttctttt aatatacttt tttgtttatc ttatttctaa     1740

tactttccct aatctctttc tttcagggca ataatgatac aatgtatcat gcctctttgc     1800

accattctaa agaataacag tgataatttc tgggttaagg caatagcaat atttctgcat     1860

ataaatattt ctgcatataa attgtaactg atgtaagagg tttcatattg ctaatagcag     1920

ctacaatcca gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg     1980

agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacagctc     2040

ctgggcaacg tgctggtctg tgtgctggcc catcactttg gcaaagaatt caccccacca     2100

gtgcaggctg cctatcagaa agtggtggct ggtgtggcta atgccctggc ccacaagtat     2160

cactaagctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc     2220

aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa     2280

aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt actaaaaagg     2340

gaatgtggga ggttgcagtg ctagtctccc ggaactatca ctctttcaca gtctgctttg     2400

gaaggactgg gcttagtatg aaaagttagg actgagaaga atttgaaagg gggctttttg     2460

tagcttgata ttcactactg tcttattacc ctatcatagg cccaccccaa atggaagtcc     2520

cattcttcct caggatgttt aagattagca ttcaggaaga gatcagaggt ctgctggctc     2580

ccttatcatg tcccttatgg tgcttctggc tctgcaccgc gggaacagag aaacaggaga     2640

atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac     2700

agttggaaca gcagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg     2760

ctcagggcca agaacagatg gtccccagat gcggtcccgc cctcagcagt ttctagagaa     2820

ccatcagatg tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact     2880

aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctctatataa     2940

gcagagctcg tttagtgaac cgtcagatcg cggccgcgcc gccaccatgg tgagcaaggg     3000

cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg     3060

ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct     3120

gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct     3180

gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt     3240

caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg     3300

caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga     3360

gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa     3420

ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa     3480

cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca     3540

gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca     3600

gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt     3660

gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaagctt tatttgtgaa     3720

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     3780

aacaattgca ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc     3840

cctgcaggca atagccttga caaggcaaac ttgaccaata gtcttagagt atccagtgag     3900

gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctt cagcagttcc     3960

acacactcgc ttctggaacg tctgaggtta tcaataagct cctagtccag acgccatggg     4020

tcatttcaca gaggaggaca aggctactat cacaagcctg tggggcaagg tgaatgtgga     4080

agatgctgga ggagaaaccc tgggaaggta ggctctggtg accaggacaa gggagggaag     4140

gaaggaccct gtgcctggca aaagtccagg tcgcttctca ggatttgtgg caccttctga     4200

ctgtcaaact gttcttgtca atctcacagg ctcctggttg tctacccatg gacccagagg     4260

ttctttgaca gctttggcaa cctgtcctct gcctctgcca tcatgggcaa ccccaaagtc     4320

aaggcacatg gcaagaaggt gctgacttcc ttgggagatg ccacaaagca cctggatgat     4380

ctcaagggca cctttgccca gctgagtgaa ctgcactgtg acaagctgca tgtggatcct     4440

gagaacttca aggtgagtcc aggagatgtt tcagccctgt tgcctttagt ctcgaggcgt     4500

cgacaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4560

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4620

gagcgagcgc gcagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     4680

ttgcgcagcc tgaatggcga atggcgattc cgttgcaatg gctggcggta atattgttct     4740

ggatattacc agcaaggccg atagtttgag ttcttctact caggcaagtg atgttattac     4800

taatcaaaga agtattgcga caacggttaa tttgcgtgat ggacagactc ttttactcgg     4860

tggcctcact gattataaaa acacttctca ggattctggc gtaccgttcc tgtctaaaat     4920

ccctttaatc ggcctcctgt ttagctcccg ctctgattct aacgaggaaa gcacgttata     4980

cgtgctcgtc aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg     5040

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg     5100

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg     5160

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt     5220

agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt     5280

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta     5340

tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa     5400

atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt     5460

aaatatttgc ttatacaatc ttcctgtttt tggggctttt ctgattatca accggggtac     5520

atatgattga catgctagtt ttacgattac cgttcatcga ttctcttgtt tgctccagac     5580

tctcaggcaa tgacctgata gcctttgtag agacctctca aaaatagcta ccctctccgg     5640

catgaattta tcagctagaa cggttgaata tcatattgat ggtgatttga ctgtctccgg     5700

cctttctcac ccgtttgaat ctttacctac acattactca ggcattgcat ttaaaatata     5760

tgagggttct aaaaattttt atccttgcgt tgaaataaag gcttctcccg caaaagtatt     5820

acagggtcat aatgtttttg gtacaaccga tttagcttta tgctctgagg ctttattgct     5880

taattttgct aattctttgc cttgcctgta tgatttattg gatgttggaa tcgcctgatg     5940

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt     6000

acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac     6060

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     6120

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc     6180

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     6240

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     6300

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     6360

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     6420

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     6480

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     6540

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     6600

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     6660

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     6720

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     6780

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     6840

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     6900

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     6960

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     7020

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     7080

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     7140

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     7200

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     7260

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     7320

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     7380

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     7440

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     7500

tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag     7560

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     7620

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     7680

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     7740

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     7800

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     7860

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     7920

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     7980

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     8040

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt     8100

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag     8160

gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa     8220

tg                                                                    8222


<210>  52
<211>  8126
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  52
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgt atacatacat acctgaatat ggaatcaaat      180

atttttctaa gatgaaacag tcatgattta tttcaaatag gtacggataa gtagatattg      240

aggtaagcat taggtcttat attatgtaac actaatctat tactgcgctg aaactgtggc      300

tttatagaaa ttgttttcac tgcactattg agaaattaag agataatggc aaaagtcaca      360

aagagtatat tcaaaaagaa gtatagcact ttttccttag aaaccactgc taactgaaag      420

agactaagat ttgtcccgtc aaaaatcctg gacctatgcc taaaacacat ttcacaatcc      480

ctgaactttt caaaaattgg tacatgcttt agctttaaac tacaggcctc actggagcta      540

gagacaagaa ggtaaaaaac ggctgacaaa agaagtcctg gtatcctcta tgatgggaga      600

aggaaactag ctaaagggaa gaataaatta gagaaaaact ggaatgactg aatcggaaca      660

aggcaaaggc tataaaaaaa attaagcagc agtatcctct tgggggcccc ttccccacac      720

tatctcaatg caaatatctg tctgaaacgg tccctggcta aactccaccc atgggttggc      780

cagccttgcc ttgacaaggc aaacttgacc aatagtctta gagtatccag tgaggccagg      840

ggccggcggc tggctaggga tgaagaataa aaggaagcac ccttcagcag ttccacacac      900

tcgcttctgg aacgtctgag gttatcaata agctcctagt ccagacgcca tggtgcacct      960

gactcctgag gagaagtctg ccgttactgc cctgtggggc aaggtgaacg tggatgaagt     1020

tggtggtgag gccctgggca ggttggtatc aaggttacaa gacaggttta aggagaccaa     1080

tagaaactgg gcatgtggag acagagaaga ctcttgggtt tctgataggc actgactctc     1140

tctgcctatt ggtctatttt cccaccctta ggctgctggt ggtctaccct tggacccaga     1200

ggttctttga gtcctttggg gatctgtcca ctcctgatgc tgttatgggc aaccctaagg     1260

tgaaggctca tggcaagaaa gtgctcggtg cctttagtga tggcctggct cacctggaca     1320

acctcaaggg cacctttgcc cagctgagtg agctgcactg tgacaagctg cacgtggatc     1380

ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct tcttttctat     1440

ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg accaaatcag     1500

ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac ttttttgttt     1560

atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga tacaatgtat     1620

catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta aggcaatagc     1680

aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag aggtttcata     1740

ttgctaatag cagctacaat ccagctacca ttctgctttt attttatggt tgggataagg     1800

ctggattatt ctgagtccaa gctaggccct tttgctaatc atgttcatac ctcttatctt     1860

cctcccacag ctcctgggca acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga     1920

attcacccca ccagtgcagg ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct     1980

ggcccacaag tatcactaag ctcgctttct tgctgtccaa tttctattaa aggttccttt     2040

gttccctaag tccaactact aaactggggg atattatgaa gggccttgag catctggatt     2100

ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat     2160

tttactaaaa agggaatgtg ggaggttgca gtgctagtct cccggaacta tcactctttc     2220

acagtctgct ttggaaggac tgggcttagt atgaaaagtt aggactgaga agaatttgaa     2280

agggggcttt ttgtagcttg atattcacta ctgtcttatt accctatcat aggcccaccc     2340

caaatggaag tcccattctt cctcaggatg tttaagatta gcattcagga agagatcaga     2400

ggtctgctgg ctcccttatc atgtccctta tggtgcttct ggctctgcac cgcggccacg     2460

gggttggggt tgcgcctttt ccaaggcagc cctgggtttg cgcagggacg cggctgctct     2520

gggcgtggtt ccgggaaacg cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc     2580

gttcgcagcg tcacccggat cttcgccgct acccttgtgg gccccccggc gacgcttcct     2640

gctccgcccc taagtcggga aggttccttg cggttcgcgg cgtgccggac gtgacaaacg     2700

gaagccgcac gtctcactag taccctcgca gacggacagc gccagggagc aatggcagcg     2760

cgccgaccgc gatgggctgt ggccaatagc ggctgctcag cggggcgcgc cgagagcagc     2820

ggccgggaag gggcggtgcg ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg     2880

cccgcgcggt gttccgcatt ctgcaagcct ccggagcgca cgtcggcagt cggctccctc     2940

gttgaccgaa tcaccgacct ctctccccag cggccgcgcc gccaccatgg acaaggattg     3000

tgaaatgaaa cgcaccacac tggacagccc tttggggaag ctggagctgt ctggttgtga     3060

gcagggtctg cacgaaataa agctcctggg caaggggacg tctgcagctg atgccgtgga     3120

ggtcccagcc cccgctgcgg ttctcggagg tccggagccc ctgatgcagt gcacagcctg     3180

gctgaatgcc tatttccacc agcccgaggc tatcgaagag ttccccgtgc cggctcttca     3240

ccatcccgtt ttccagcaag agtcgttcac cagacaggtg ttatggaagc tgctgaaggt     3300

tgtgaaattc ggagaagtga tttcttacca gcaattagca gccctggcag gcaaccccaa     3360

agccgcgcga gcagtgggag gagcaatgag aggcaatcct gtcaaaatcc tcatcccgtg     3420

ccacagagtg gtctgcagca gcggagccgt gggcaactac tccggaggac tggccgtgaa     3480

ggaatggctt ctggcccatg aaggccaccg gttggggaag ccaggcttgg gagggagctc     3540

aggtctggca ggggcctggc tcaagggagc gggagctacc tcgggctccc cgcctgctgg     3600

ccgaaactaa gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     3660

agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg     3720

gagatgtggg aggtttttta aagccctgca ggcaatagcc ttgacaaggc aaacttgacc     3780

aatagtctta gagtatccag tgaggccagg ggccggcggc tggctaggga tgaagaataa     3840

aaggaagcac ccttcagcag ttccacacac tcgcttctgg aacgtctgag gttatcaata     3900

agctcctagt ccagacgcca tgggtcattt cacagaggag gacaaggcta ctatcacaag     3960

cctgtggggc aaggtgaatg tggaagatgc tggaggagaa accctgggaa ggtaggctct     4020

ggtgaccagg acaagggagg gaaggaagga ccctgtgcct ggcaaaagtc caggtcgctt     4080

ctcaggattt gtggcacctt ctgactgtca aactgttctt gtcaatctca caggctcctg     4140

gttgtctacc catggaccca gaggttcttt gacagctttg gcaacctgtc ctctgcctct     4200

gccatcatgg gcaaccccaa agtcaaggca catggcaaga aggtgctgac ttccttggga     4260

gatgccacaa agcacctgga tgatctcaag ggcacctttg cccagctgag tgaactgcac     4320

tgtgacaagc tgcatgtgga tcctgagaac ttcaaggtga gtccaggaga tgtttcagcc     4380

ctgttgcctt tagtctcgag gcgtcgacag gaacccctag tgatggagtt ggccactccc     4440

tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc     4500

tttgcccggg cggcctcagt gagcgagcga gcgcgcagct ggcgtaatag cgaagaggcc     4560

cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggcg attccgttgc     4620

aatggctggc ggtaatattg ttctggatat taccagcaag gccgatagtt tgagttcttc     4680

tactcaggca agtgatgtta ttactaatca aagaagtatt gcgacaacgg ttaatttgcg     4740

tgatggacag actcttttac tcggtggcct cactgattat aaaaacactt ctcaggattc     4800

tggcgtaccg ttcctgtcta aaatcccttt aatcggcctc ctgtttagct cccgctctga     4860

ttctaacgag gaaagcacgt tatacgtgct cgtcaaagca accatagtac gcgccctgta     4920

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     4980

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     5040

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     5100

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     5160

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     5220

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     5280

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     5340

acaaaatatt aacgtttaca atttaaatat ttgcttatac aatcttcctg tttttggggc     5400

ttttctgatt atcaaccggg gtacatatga ttgacatgct agttttacga ttaccgttca     5460

tcgattctct tgtttgctcc agactctcag gcaatgacct gatagccttt gtagagacct     5520

ctcaaaaata gctaccctct ccggcatgaa tttatcagct agaacggttg aatatcatat     5580

tgatggtgat ttgactgtct ccggcctttc tcacccgttt gaatctttac ctacacatta     5640

ctcaggcatt gcatttaaaa tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat     5700

aaaggcttct cccgcaaaag tattacaggg tcataatgtt tttggtacaa ccgatttagc     5760

tttatgctct gaggctttat tgcttaattt tgctaattct ttgccttgcc tgtatgattt     5820

attggatgtt ggaatcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca     5880

caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc     5940

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     6000

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     6060

ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     6120

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     6180

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     6240

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     6300

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     6360

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     6420

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     6480

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     6540

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     6600

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     6660

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     6720

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     6780

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc     6840

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     6900

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     6960

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     7020

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     7080

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     7140

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     7200

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     7260

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     7320

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     7380

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     7440

ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     7500

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     7560

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     7620

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     7680

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     7740

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     7800

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     7860

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     7920

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     7980

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     8040

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     8100

cccgcgcgtt ggccgattca ttaatg                                          8126


<210>  53
<211>  8168
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  53
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctgcggccg cgatgtgagg acacagtggg aagtcagcca cctgcaaccc      180

aggaagagag ccctgaccag gaaccagcag aaaagtgaga aaaaatcctg ttgttgaagt      240

cacccagtct atgctatttt gttatagcac cttgcactaa gtaaggcaga tgaagaaaga      300

gaaaaaaata agcttcggtg ttcagtggat tagaaaccat gtttatctca ggtttacaaa      360

tctccacttg tcctctgtgt ttcagaataa aataccaact ctactactct catctgtaag      420

atgcaaatag taagcctgag cccttctgtc taactttgaa ttctattttt tcttcaacgt      480

actttaggct tgtaatgtgt ttatatacag tgaaatgtca agttctttct ttatatttct      540

ttctttcttt tttttcctca gcctcagagt tttccacatg cccttcctac tttcaggaac      600

ttctttctcc aaacgtcttc tgcctggctc catcaaatca taaaggaccc acttcaaatg      660

ccatcactca ctaccatttc acaattcgca ctttctttct ttgtcctttt tttttttagt      720

aaaacaagtt tataaaaaat tgaaggaata aatgaatggc tacttcatag gcagagtaga      780

cgcaagggct actggttgcc gatttttatt gttatttttc aatagtatgc taaacaaggg      840

gtagattatt tatgctgccc atttttagac cataaaagat aacttcctga tgttgccatg      900

gcattttttt ccttttaatt ttatttcatt tcattttaat ttcgaaggta catgtgcagg      960

atgtgcaggc ttgttacatg ggtaaatgtg tgtctttctg gccttttagc catctgtatc     1020

aatgagcaga tataagcttt acacaggatc atgaaggatg aaagaatttc accaatatta     1080

taataatttc aatcaacctg atagcttagg ggataaacta atttgaagat acagcttgcc     1140

tccgataagc cagaattcca gagcttctgg cattataatc tagcaaggtt agagatcatg     1200

gatcactttc agagaaaaac aaaaacaaac taaccaaaag caaaacagaa ccaaaaaacc     1260

accataaata cttcctaccc tgttaatggt ccaatatgtc agaaacagca ctgtgttaga     1320

aataaagctg tctaaagtac actaatattc gagttataat agtgtgtgga ctattagtca     1380

ataaaaacaa cccttgcctc tttagagttg ttttccatgt acacgcacat cttatgtctt     1440

agagtaagat tccctgagaa gtgaacctag catttataca agataattaa ttctaatcca     1500

cagtacctgc caaagaacat tctaccatca tctttactga gcatagaaga gctacgccaa     1560

aaccctgggt catcagccag cacacacact tatccagtgg taaatacaca tcatctggtg     1620

tatacataca tacctgaata tggaatcaaa tatttttcta agatgaaaca gtcatgattt     1680

atttcaaata ggtacggata agtagatatt gaggtaagca ttaggtctta tattatgtaa     1740

cactaatcta ttactgcgct gaaactgtgg ctttatagaa attgttttca ctgcactatt     1800

gagaaattaa gagataatgg caaaagtcac aaagagtata ttcaaaaaga agtatagcac     1860

tttttcctta gaaaccactg ctaactgaaa gagactaaga tttgtcccgt caaaaatcct     1920

ggacctatgc ctaaaacaca tttcacaatc cctgaacttt tcaaaaattg gtacatgctt     1980

tagctttaaa ctacaggcct cactggagct agagacaaga aggtaaaaaa cggctgacaa     2040

aagaagtcct ggtatcctct atgatgggag aaggaaacta gctaaaggga agaataaatt     2100

agagaaaaac tggaatgact gaatcggaac aaggcaaagg ctataaaaaa aattagcagt     2160

atcctcttgg gggccccttc cccacactat ctcaatgcaa atatctgtct gaaacggtcc     2220

ctggctaaac tccacccatg ggttggccag ccttgccttg acaaggcaaa cttgaccaat     2280

agtcttagag tatccagtga ggccaggggc cggcggctgg ctagggatga agaataaaag     2340

gaagcaccct tcagcagttc cacacactcg cttctggaac gtctgaggtt atcaataagc     2400

tcctagtcca gacgccatgg gtcatttcac agaggaggac aaggctacta tcacaagcct     2460

gtggggcaag gtgaatgtgg aagatgctgg aggagaaacc ctgggaaggt aggctctggt     2520

gaccaggaca agggagggaa ggaaggaccc tgtgcctggc aaaagtccag gtcgcttctc     2580

aggatttgtg gcaccttctg actgtcaaac tgttcttgtc aatctcacag gctcctggtt     2640

gtctacccat ggacccagag gttctttgac agctttggca acctgtcctc tgcctctgcc     2700

atcatgggca accccaaagt caaggcacat ggcaagaagg tgctgacttc cttgggagat     2760

gccacaaagc acctggatga tctcaagggc acctttgccc agctgagtga actgcactgt     2820

gacaagctgc atgtggatcc tgagaacttc aaggtgagtc caggagatgt ttcagccctg     2880

ttgcctttag tctcgaggca acttagacaa cggagtattg atctgagcac agcagggtgt     2940

gagctgtttg aagatactgg ggttgggggt gaagaaactg cagaggacta actgggctga     3000

gacccagtgg taatgtttta gggcctaagg agtgcctcta aaaatctaga tggacaattt     3060

tgactttgag aaaagagagg tggaaatgag gaaaatgact tttctttatt agattccagt     3120

agaaagaact ttcatctttc cctcattttt gttgttttaa aacatctatc tggaggcagg     3180

acaagtatgg tcgttaaaaa gatgcaggca gaaggcatat attggctcag tcaaagtggg     3240

gaactttggt ggccaaacat acattgctaa ggctattcct atatcagctg gacacatata     3300

aaatgctgct aatgcttcat tacaaactta tatcctttaa ttccagatgg gggcaaagta     3360

tgtccagggg tgaggaacaa ttgaaacatt tgggctggag tagattttga aagtcagctc     3420

tgtgtgtgtg tgtgtgtgtg cgcgcgcgcg tgtgtgtgtg tgtgtcagcg tgtgtttctt     3480

ttaacgtctt cagcctacaa catacagggt tcatggtggc aagaagatag caagatttaa     3540

attatggcca gtgactagtg cttgaagggg aacaactacc tgcatttaat gggaaggcaa     3600

aatctcaggc tttgagggaa gttaacatag gcttgattct gggtggaagc ttggtgtgta     3660

gttatctgga ggccaggctg gagctctcag ctcactatgg gttcatcttt attgtctcct     3720

ttcatctcaa cagctcctgg gaaatgtgct ggtgaccgtt ttggcaatcc atttcggcaa     3780

agaattcacc cctgaggtgc aggcttcctg gcagaagatg gtgactgcag tggccagtgc     3840

cctgtcctcc agataccact gagctcactg cccatgattc agagctttca aggataggct     3900

ttattctgca agcaatacaa ataataaatc tattctgctg agagatcaca catgattttc     3960

ttcagctctt ttttttacat ctttttaaat atatgagcca caaagggttt atattgaggg     4020

aagtgtgtat gtgtatttct gcatgcctgt ttgtgtttgt ggtgtgtgca tgctcctcat     4080

ttatttttat atgagatgtg cattttgatg agcaaataaa agcagtaaag acacttgtac     4140

acgggagttc tgcaagtggg agtaaatggt gtaggagaaa tccggtggga agaaagacct     4200

ctataggaca ggacttctca gaaacagatg ttttggaaga gatgggaaaa ggttcagtga     4260

agacctgggg gctggattga ttgcagctga gtagcaagga tggttcttaa ggaagggaaa     4320

gtgttccaag ctttaggaat tcaaggttta gtcaggtgta gcaattctat tttattagga     4380

ggaatactat ttctaatggc acttagcttt tcacagccct tgtggatgcc taaatcggat     4440

cccctgcagg aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4500

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     4560

gtgagcgagc gagcgcgcag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     4620

caacagttgc gcagcctgaa tggcgaatgg cgattccgtt gcaatggctg gcggtaatat     4680

tgttctggat attaccagca aggccgatag tttgagttct tctactcagg caagtgatgt     4740

tattactaat caaagaagta ttgcgacaac ggttaatttg cgtgatggac agactctttt     4800

actcggtggc ctcactgatt ataaaaacac ttctcaggat tctggcgtac cgttcctgtc     4860

taaaatccct ttaatcggcc tcctgtttag ctcccgctct gattctaacg aggaaagcac     4920

gttatacgtg ctcgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg     4980

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     5040

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     5100

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     5160

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     5220

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     5280

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     5340

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta     5400

caatttaaat atttgcttat acaatcttcc tgtttttggg gcttttctga ttatcaaccg     5460

gggtacatat gattgacatg ctagttttac gattaccgtt catcgattct cttgtttgct     5520

ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct     5580

ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt     5640

ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa     5700

aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa     5760

agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt     5820

attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaatcgc     5880

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact     5940

ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc     6000

gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc     6060

gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga     6120

aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag     6180

acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     6240

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     6300

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     6360

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     6420

gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt     6480

gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt     6540

ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat     6600

tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg     6660

acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta     6720

cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat     6780

catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag     6840

cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa     6900

ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca     6960

ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc     7020

ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt     7080

atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc     7140

gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat     7200

atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt     7260

tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac     7320

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc     7380

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca     7440

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta     7500

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct     7560

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg     7620

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc     7680

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta     7740

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg     7800

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt     7860

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg     7920

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg     7980

ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc     8040

gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg     8100

agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt     8160

cattaatg                                                              8168


<210>  54
<211>  7556
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  54
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttaagtata gcacaatgct tactaaatga gactaagact tgtcccatcg aaaatcctgg      240

acctatgcct aaaacacgtg tcacaatccc cgaacttttc aaaaattggt acatgcttta      300

actttaatct ccaggcctca ctggagctag agacaagaag gtaaaaaaag gctgacaaaa      360

gaagtcctgg tatcttctat ggtgggagaa ggaaactagc taaagggaag aataaattag      420

agaaaaattg gaatgattga atcggaacaa ggcaaaggct ataaaaaaat taagcagcag      480

tatcctcttg ggggcccctt ccccacacta tctcaatgca aatatctgtc tgaaacggtc      540

cctggctaaa ctccacccat gggttggcca gtcttgcctt gacaaggcaa ccttgaccaa      600

tagtcttaga gtatcaggtg aggccagggg ccggcggctg gctagggatg aagaataaaa      660

ggaagcaccc tccagcagtt ccacacactc gcttctggaa cggctgagat tatcaataag      720

ctcctagtcc agacgccatg gtgcacctga ctcctgagga gaagtctgcc gttactgccc      780

tgtggggcaa ggtgaacgtg gatgaagttg gtggtgaggc cctgggcagg ttggtatcaa      840

ggttacaaga caggtttaag gagaccaata gaaactgggc atgtggagac agagaagact      900

cttgggtttc tgataggcac tgactctctc tgcctattgg tctattttcc cacccttagg      960

ctgctggtgg tctacccttg gacccagagg ttctttgagt cctttgggga tctgtccact     1020

cctgatgctg ttatgggcaa ccctaaggtg aaggctcatg gcaagaaagt gctcggtgcc     1080

tttagtgatg gcctggctca cctggacaac ctcaagggca cctttgccca gctgagtgag     1140

ctgcactgtg acaagctgca cgtggatcct gagaacttca gggtgagtct atgggaccct     1200

tgatgttttc tttccccttc ttttctatgg ttaagttcat gtcataggaa ggggagaagt     1260

aacagggtac acatattgac caaatcaggg taattttgca tttgtaattt taaaaaatgc     1320

tttcttcttt taatatactt ttttgtttat cttatttcta atactttccc taatctcttt     1380

ctttcagggc aataatgata caatgtatca tgcctctttg caccattcta aagaataaca     1440

gtgataattt ctgggttaag gcaatagcaa tatttctgca tataaatatt tctgcatata     1500

aattgtaact gatgtaagag gtttcatatt gctaatagca gctacaatcc agctaccatt     1560

ctgcttttat tttatggttg ggataaggct ggattattct gagtccaagc taggcccttt     1620

tgctaatcat gttcatacct cttatcttcc tcccacagct cctgggcaac gtgctggtct     1680

gtgtgctggc ccatcacttt ggcaaagaat tcaccccacc agtgcaggct gcctatcaga     1740

aagtggtggc tggtgtggct aatgccctgg cccacaagta tcactaagct cgctttcttg     1800

ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa actgggggat     1860

attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat tttcattgca     1920

atgatgtatt taaattattt ctgaatattt tactaaaaag ggaatgtggg aggttgcagt     1980

gctagtctcc cggaactatc actctttcac agtctgcttt ggaaggactg ggcttagtat     2040

gaaaagttag gactgagaag aatttgaaag ggggcttttt gtagcttgat attcactact     2100

gtcttattac cctatcatag gcccacccca aatggaagtc ccattcttcc tcaggatgtt     2160

taagattagc attcaggaag agatcagagg tctgctggct cccttatcat gtcccttatg     2220

gtgcttctgg ctctgcaccg cgggaacaga gaaacaggag aatatgggcc aaacaggata     2280

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagttggaac agcagaatat     2340

gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat     2400

ggtccccaga tgcggtcccg ccctcagcag tttctagaga accatcagat gtttccaggg     2460

tgccccaagg acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct     2520

cgcttctgtt cgcgcgcttc tgctccccga gctctatata agcagagctc gtttagtgaa     2580

ccgtcagatc gcggccgcgc cgccaccatg gtgagcaagg gcgaggagct gttcaccggg     2640

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     2700

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     2760

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc     2820

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     2880

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     2940

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     3000

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc     3060

tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac     3120

atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac     3180

ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac     3240

cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact     3300

ctcggcatgg acgagctgta caaggagggc agaggaagtc ttctaacatg cggtgacgtg     3360

gaggagaatc cgggcccccc tgcaggaact tcagggtgag tccaggagtt tcagcagttt     3420

cagagttcag tctcaaggca acttagacaa ctgagtattg atctgaggac agtcgaatct     3480

acctgctggg tgtgagctat ttgaagatac tggggttggg agtgaagaaa ctgcagagga     3540

ctaactgggc tgagaccgaa tggtaatgtt ttagggccta aggagtgcct ctaaaaatct     3600

agacggacaa ttttgacatt gacaaaagag aggtggaaat gaggaaaatg acttttcttt     3660

attagattcc ggtagaaaga actttcatct ttccctcatt tttgttattt gttttaaaac     3720

atctatctgg aggcaggaca agtatggtca ttaaaaagat gcaggcagaa ggcatatatt     3780

ggcccagtca aagtgtcgac gtagataagt agcatggcgg gttaatcatt aactacaagg     3840

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     3900

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     3960

cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc     4020

agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg ttctggatat     4080

taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta ttactaatca     4140

aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac tcggtggcct     4200

cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta aaatcccttt     4260

aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt tatacgtgct     4320

cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     4380

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     4440

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     4500

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg     4560

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     4620

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     4680

tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc     4740

tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca atttaaatat     4800

ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg gtacatatga     4860

ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc agactctcag     4920

gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct ccggcatgaa     4980

tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct ccggcctttc     5040

tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa tatatgaggg     5100

ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag tattacaggg     5160

tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat tgcttaattt     5220

tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct gatgcggtat     5280

tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc     5340

tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc     5400

tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc     5460

tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg     5520

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc     5580

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     5640

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     5700

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     5760

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     5820

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     5880

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     5940

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     6000

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     6060

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     6120

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     6180

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     6240

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     6300

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     6360

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     6420

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     6480

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     6540

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     6600

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     6660

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     6720

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     6780

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     6840

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     6900

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     6960

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     7020

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     7080

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     7140

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     7200

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     7260

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     7320

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     7380

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     7440

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     7500

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatg         7556


<210>  55
<211>  7635
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  55
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtagat      180

cttcccaact gtcacagtgt gtggcctatt agtcaattaa agcagtccct gcctctttag      240

agttgttttc catgcaatta catgtcttat gtcttagaat aagattccct gagaactgaa      300

cctagcattt atacaagata attaattcta agccatagta cctgccaaag aacattctac      360

tatcatcttt actgaacaca gaagagctac accaaaaacc tgggtcatca gccagcacac      420

acacttatcc agtgataaat acacatcatc gggtgcctac atacatacct gaataagaaa      480

aaaaaatacc tttgctgaga tgaaacacac atgatttatt tcaaataggt acagagaagt      540

agatactgaa gtaaggatta agtattatat tatattacat aacattaatc tattcctgca      600

ctgaaaccgt tgctttatat gatttttttt ttcactacac taatgagaac ttaagagata      660

atggcctaaa accacagaga gtattttcaa agataagtat agcacaatgc ttactaaatg      720

agactaagac ttgtcccatc gaaaatcctg gacctatgcc taaaacacgt gtcacaatcc      780

ccgaactttt caaaaattgg tacatgcttt aactttaatc tccaggcctc actggagcta      840

gagacaagaa ggtaaaaaaa ggctgacaaa agaagtcctg gtatcttcta tggtgggaga      900

aggaaactag ctaaagggaa gaataaatta gagaaaaatt ggaatgattg aatcggaaca      960

aggcaaaggc tataaaaaaa ttaagcagca gtatcctctt gggggcccct tccccacact     1020

atctcaatgc aaatatctgt ctgaaacggt ccctggctaa actccacccg cgggaacaga     1080

gaaacaggag aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca     1140

gggccaagaa cagttggaac agcagaatat gggccaaaca ggatatctgt ggtaagcagt     1200

tcctgccccg gctcagggcc aagaacagat ggtccccaga tgcggtcccg ccctcagcag     1260

tttctagaga accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc     1320

ttatttgaac taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga     1380

gctctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac gccatccacg     1440

ctgttttgac ttccatagaa ggcggccgcg ccgccaccat ggtgagcaag ggcgaggagc     1500

tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt     1560

tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca     1620

tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg     1680

gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg     1740

ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca     1800

agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg     1860

gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca     1920

gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga     1980

tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc     2040

ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc     2100

tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg     2160

ccgggatcac tctcggcatg gacgagctgt acaagtaacc tgcagggata atcaacctct     2220

ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct     2280

atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat     2340

tttctcctcc ttgtataaat cctggttagt tcttgccacg gcggaactca tcgccgcctg     2400

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgtttat     2460

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ctagctttat ttgtgaaatt     2520

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     2580

aattgcattc attttatgtt tcaggttcag ggggagatgt gggaggtttt ttaaagcgaa     2640

ttcgtaaata cacttgcaaa ggaggatgtt tttagtagca atttgtactg atggtatggg     2700

gccaagagat atatcttaga gggagggctg agggtttgaa gtccaactcc taagccagtg     2760

ccagaagagc caaggacagg tacggctgtc atcacttaga cctcaccctg tggagccaca     2820

ccctagggtt ggccaatcta ctcccaggag cagggagggc aggagccagg gctgggcata     2880

aaagtcaggg cagagccatc tattgcttac actcgcttct ggaacggctg agattatcaa     2940

taagctccta gtccagacgc catgggtcat ttcacagagg aggacaaggc tactatcaca     3000

agcctgtggg gcaaggtgaa tgtggaagat gctggaggag aaaccctggg aaggtaggct     3060

ctggtgacca ggacaaggaa gggaaggaag gaccctgtgc ctggcaaaag tccaggccac     3120

ttctcaggat ttgtggcact ttctgactgt caaactgctc ttgttcaatc tcacaggctc     3180

ctggttgtct acccatggac ccagaggttc tttgacagct ttggcaacct gtcctctgcc     3240

tctgccatca tgggcaaccc caaggtcaag gcacacggca agaaggtgct gacttccttg     3300

ggagatgcca taaagaacct ggatgatctc aagggcacct ttgcccagct gagtgagctg     3360

cactgtgaca agctgcatgt ggatcctgag aacttcaggg tgagtccagg agtttcagca     3420

gtttcagagt tcagtctcaa ggcaacttag acaactgagt attgatctga ggacagtcga     3480

atctacctgc tgggtgtgag ctatttgaag atactggggt tgggagtgaa gaaactgcag     3540

aggactaact gggctgagac cgaatggtaa tgttttaggg cctaaggagt gcctctaaaa     3600

atctagacgg acaattttga cattgacaaa agagaggtgg aaatgaggaa aatgactttt     3660

ctttattaga ttccggtaga aagaactttc atctttccct catttttgtt atttgtttta     3720

aaacatctat ctggaggcag gacaagtatg gtcattaaaa agatgcaggc agaaggcata     3780

tattggccca gtcaaagtgg ggaactctgg tgaccaaaca gagtctgagg ctattcctat     3840

atcagctgga cacatacaaa atgccgcctc gaggtcgacg tagataagta gcatggcggg     3900

ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct     3960

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     4020

gcctcagtga gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg     4080

cccttcccaa cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg     4140

gtaatattgt tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa     4200

gtgatgttat tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga     4260

ctcttttact cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt     4320

tcctgtctaa aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg     4380

aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta     4440

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     4500

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     4560

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     4620

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     4680

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     4740

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     4800

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta     4860

acgtttacaa tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta     4920

tcaaccgggg tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt     4980

gtttgctcca gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag     5040

ctaccctctc cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt     5100

tgactgtctc cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg     5160

catttaaaat atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc     5220

ccgcaaaagt attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg     5280

aggctttatt gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg     5340

gaatcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg     5400

gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc     5460

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc     5520

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc     5580

gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt     5640

ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt     5700

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca     5760

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt     5820

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga     5880

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa     5940

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct     6000

gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat     6060

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga     6120

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc     6180

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat     6240

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa     6300

cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac     6360

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa     6420

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc     6480

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc     6540

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag     6600

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta     6660

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa     6720

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc     6780

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat     6840

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga     6900

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt     6960

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata     7020

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac     7080

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg     7140

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg     7200

tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag     7260

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct     7320

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc     7380

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt     7440

ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg     7500

tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga     7560

gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg     7620

gccgattcat taatg                                                      7635


<210>  56
<211>  8285
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  56
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgc ctacatacat acctgaataa gaaaaaaaaa      180

tacctttgct gagatgaaac acacatgatt tatttcaaat aggtacagag aagtagatac      240

tgaagtaagg attaagtatt atattatatt acataacatt aatctattcc tgcactgaaa      300

ccgttgcttt atatgatttt ttttttcact acactaatga gaacttaaga gataatggcc      360

taaaaccaca gagagtattt tcaaagataa gtatagcaca atgcttacta aatgagacta      420

agacttgtcc catcgaaaat cctggaccta tgcctaaaac acgtgtcaca atccccgaac      480

ttttcaaaaa ttggtacatg ctttaacttt aatctccagg cctcactgga gctagagaca      540

agaaggtaaa aaaaggctga caaaagaagt cctggtatct tctatggtgg gagaaggaaa      600

ctagctaaag ggaagaataa attagagaaa aattggaatg attgaatcgg aacaaggcaa      660

aggctataaa aaaattaagc agcagtatcc tcttgggggc cccttcccca cactatctca      720

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagtctt      780

gccttgacgc tagcgtaaat acacttgcaa aggaggatgt ttttagtagc aatttgtact      840

gatggtatgg ggccaagaga tatatcttag agggagggct gagggtttga agtccaactc      900

ctaagccagt gccagaagag ccaaggacag gtacggctgt catcacttag acctcaccct      960

gtggagccac accctagggt tggccaatct actcccagga gcagggaggg caggagccag     1020

ggctgggcat aaaagtcagg gcagagccat ctattgctta catttgcttc tgacacaact     1080

gtgttcacta gcaacctcaa acagacacca tggtgcacct gactcctgag gagaagtctg     1140

ccgttactgc cctgtggggc aaggtgaacg tggatgaagt tggtggtgag gccctgggca     1200

ggttggtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcatgtggag     1260

acagagaaga ctcttgggtt tctgataggc actgactctc tctgcctatt ggtctatttt     1320

cccaccctta ggctgctggt ggtctaccct tggacccaga ggttctttga gtcctttggg     1380

gatctgtcca ctcctgatgc tgttatgggc aaccctaagg tgaaggctca tggcaagaaa     1440

gtgctcggtg cctttagtga tggcctggct cacctggaca acctcaaggg cacctttgcc     1500

cagctgagtg agctgcactg tgacaagctg cacgtggatc ctgagaactt cagggtgagt     1560

ctatgggacc cttgatgttt tctttcccct tcttttctat ggttaagttc atgtcatagg     1620

aaggggagaa gtaacagggt acacatattg accaaatcag ggtaattttg catttgtaat     1680

tttaaaaaat gctttcttct tttaatatac ttttttgttt atcttatttc taatactttc     1740

cctaatctct ttctttcagg gcaataatga tacaatgtat catgcctctt tgcaccattc     1800

taaagaataa cagtgataat ttctgggtta aggcaatagc aatatttctg catataaata     1860

tttctgcata taaattgtaa ctgatgtaag aggtttcata ttgctaatag cagctacaat     1920

ccagctacca ttctgctttt attttatggt tgggataagg ctggattatt ctgagtccaa     1980

gctaggccct tttgctaatc atgttcatac ctcttatctt cctcccacag ctcctgggca     2040

acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga attcacccca ccagtgcagg     2100

ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct ggcccacaag tatcactaag     2160

ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact     2220

aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt     2280

attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa agggaatgtg     2340

ggaggttgca gtgctagtct cccggaacta tcactctttc acagtctgct ttggaaggac     2400

tgggcttagt atgaaaagtt aggactgaga agaatttgaa agggggcttt ttgtagcttg     2460

atattcacta ctgtcttatt accctatcat aggcccaccc caaatggaag tcccattctt     2520

cctcaggatg tttaagatta gcattcagga agagatcaga ggtctgctgg ctcccttatc     2580

atgtccctta tggtgcttct ggctctgcac cgcggccacg gggttggggt tgcgcctttt     2640

ccaaggcagc cctgggtttg cgcagggacg cggctgctct gggcgtggtt ccgggaaacg     2700

cagcggcgcc gaccctgggt ctcgcacatt cttcacgtcc gttcgcagcg tcacccggat     2760

cttcgccgct acccttgtgg gccccccggc gacgcttcct gctccgcccc taagtcggga     2820

aggttccttg cggttcgcgg cgtgccggac gtgacaaacg gaagccgcac gtctcactag     2880

taccctcgca gacggacagc gccagggagc aatggcagcg cgccgaccgc gatgggctgt     2940

ggccaatagc ggctgctcag cggggcgcgc cgagagcagc ggccgggaag gggcggtgcg     3000

ggaggcgggg tgtggggcgg tagtgtgggc cctgttcctg cccgcgcggt gttccgcatt     3060

ctgcaagcct ccggagcgca cgtcggcagt cggctccctc gttgaccgaa tcaccgacct     3120

ctctccccag cggccgcgcc gccaccatgg acaaggattg tgaaatgaaa cgcaccacac     3180

tggacagccc tttggggaag ctggagctgt ctggttgtga gcagggtctg cacgaaataa     3240

agctcctggg caaggggacg tctgcagctg atgccgtgga ggtcccagcc cccgctgcgg     3300

ttctcggagg tccggagccc ctgatgcagt gcacagcctg gctgaatgcc tatttccacc     3360

agcccgaggc tatcgaagag ttccccgtgc cggctcttca ccatcccgtt ttccagcaag     3420

agtcgttcac cagacaggtg ttatggaagc tgctgaaggt tgtgaaattc ggagaagtga     3480

tttcttacca gcaattagca gccctggcag gcaaccccaa agccgcgcga gcagtgggag     3540

gagcaatgag aggcaatcct gtcaaaatcc tcatcccgtg ccacagagtg gtctgcagca     3600

gcggagccgt gggcaactac tccggaggac tggccgtgaa ggaatggctt ctggcccatg     3660

aaggccaccg gttggggaag ccaggcttgg gagggagctc aggtctggca ggggcctggc     3720

tcaagggagc gggagctacc tcgggctccc cgcctgctgg ccgaaactaa gctttatttg     3780

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     3840

caacaacaat tgcattcatt ttatgtttca ggttcagggg gagatgtggg aggtttttta     3900

aagccctgca ggcaatagcc ttgacaaggc aaccttgacc aatagtctta gagtatcagg     3960

tgaggccagg ggccggcggc tggctaggga tgaagaataa aaggaagcac cctccagcag     4020

ttccacacac tcgcttctgg aacggctgag attatcaata agctcctagt ccagacgcca     4080

tgggtcattt cacagaggag gacaaggcta ctatcacaag cctgtggggc aaggtgaatg     4140

tggaagatgc tggaggagaa accctgggaa ggtaggctct ggtgaccagg acaaggaagg     4200

gaaggaagga ccctgtgcct ggcaaaagtc caggccactt ctcaggattt gtggcacttt     4260

ctgactgtca aactgctctt gttcaatctc acaggctcct ggttgtctac ccatggaccc     4320

agaggttctt tgacagcttt ggcaacctgt cctctgcctc tgccatcatg ggcaacccca     4380

aggtcaaggc acacggcaag aaggtgctga cttccttggg agatgccata aagaacctgg     4440

atgatctcaa gggcaccttt gcccagctga gtgagctgca ctgtgacaag ctgcatgtgg     4500

atcctgagaa cttcagggtg agtccaggag tttcagcagt ttcagagttc agtctcaagg     4560

cgtcgacagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     4620

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     4680

agcgagcgag cgcgcagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa     4740

cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt     4800

tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat     4860

tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact     4920

cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa     4980

aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt     5040

atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg     5100

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     5160

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     5220

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     5280

attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga     5340

cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc     5400

ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa     5460

aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa     5520

tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg     5580

tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca     5640

gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc     5700

cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc     5760

cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat     5820

atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt     5880

attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt     5940

gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg     6000

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc     6060

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct     6120

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     6180

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag     6240

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg     6300

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     6360

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     6420

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     6480

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     6540

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     6600

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     6660

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     6720

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     6780

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     6840

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     6900

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     6960

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     7020

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     7080

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     7140

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     7200

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     7260

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     7320

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     7380

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     7440

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     7500

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     7560

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     7620

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     7680

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     7740

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     7800

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     7860

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     7920

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     7980

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     8040

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     8100

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     8160

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     8220

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat     8280

taatg                                                                 8285


<210>  57
<211>  8214
<212>  DNA
<213>  Artificial

<220>
<223>  AAV donor template

<400>  57
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cctacgcgta gatctggtgc ctacatacat acctgaataa gaaaaaaaaa      180

tacctttgct gagatgaaac acacatgatt tatttcaaat aggtacagag aagtagatac      240

tgaagtaagg attaagtatt atattatatt acataacatt aatctattcc tgcactgaaa      300

ccgttgcttt atatgatttt ttttttcact acactaatga gaacttaaga gataatggcc      360

taaaaccaca gagagtattt tcaaagataa gtatagcaca atgcttacta aatgagacta      420

agacttgtcc catcgaaaat cctggaccta tgcctaaaac acgtgtcaca atccccgaac      480

ttttcaaaaa ttggtacatg ctttaacttt aatctccagg cctcactgga gctagagaca      540

agaaggtaaa aaaaggctga caaaagaagt cctggtatct tctatggtgg gagaaggaaa      600

ctagctaaag ggaagaataa attagagaaa aattggaatg attgaatcgg aacaaggcaa      660

aggctataaa aaaattaagc agcagtatcc tcttgggggc cccttcccca cactatctca      720

atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagtctt      780

gccttgacgc tagcgtaaat acacttgcaa aggaggatgt ttttagtagc aatttgtact      840

gatggtatgg ggccaagaga tatatcttag agggagggct gagggtttga agtccaactc      900

ctaagccagt gccagaagag ccaaggacag gtacggctgt catcacttag acctcaccct      960

gtggagccac accctagggt tggccaatct actcccagga gcagggaggg caggagccag     1020

ggctgggcat aaaagtcagg gcagagccat ctattgctta catttgcttc tgacacaact     1080

gtgttcacta gcaacctcaa acagacacca tggtgcacct gactcctgag gagaagtctg     1140

ccgttactgc cctgtggggc aaggtgaacg tggatgaagt tggtggtgag gccctgggca     1200

ggttggtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcatgtggag     1260

acagagaaga ctcttgggtt tctgataggc actgactctc tctgcctatt ggtctatttt     1320

cccaccctta ggctgctggt ggtctaccct tggacccaga ggttctttga gtcctttggg     1380

gatctgtcca ctcctgatgc tgttatgggc aaccctaagg tgaaggctca tggcaagaaa     1440

gtgctcggtg cctttagtga tggcctggct cacctggaca acctcaaggg cacctttgcc     1500

cagctgagtg agctgcactg tgacaagctg cacgtggatc ctgagaactt cagggtgagt     1560

ctatgggacc cttgatgttt tctttcccct tcttttctat ggttaagttc atgtcatagg     1620

aaggggagaa gtaacagggt acacatattg accaaatcag ggtaattttg catttgtaat     1680

tttaaaaaat gctttcttct tttaatatac ttttttgttt atcttatttc taatactttc     1740

cctaatctct ttctttcagg gcaataatga tacaatgtat catgcctctt tgcaccattc     1800

taaagaataa cagtgataat ttctgggtta aggcaatagc aatatttctg catataaata     1860

tttctgcata taaattgtaa ctgatgtaag aggtttcata ttgctaatag cagctacaat     1920

ccagctacca ttctgctttt attttatggt tgggataagg ctggattatt ctgagtccaa     1980

gctaggccct tttgctaatc atgttcatac ctcttatctt cctcccacag ctcctgggca     2040

acgtgctggt ctgtgtgctg gcccatcact ttggcaaaga attcacccca ccagtgcagg     2100

ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct ggcccacaag tatcactaag     2160

ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact     2220

aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt     2280

attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa agggaatgtg     2340

ggaggttgca gtgctagtct cccggaacta tcactctttc acagtctgct ttggaaggac     2400

tgggcttagt atgaaaagtt aggactgaga agaatttgaa agggggcttt ttgtagcttg     2460

atattcacta ctgtcttatt accctatcat aggcccaccc caaatggaag tcccattctt     2520

cctcaggatg tttaagatta gcattcagga agagatcaga ggtctgctgg ctcccttatc     2580

atgtccctta tggtgcttct ggctctgcac cgcgggaaca gagaaacagg agaatatggg     2640

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga     2700

acagcagaat atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg     2760

ccaagaacag atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag     2820

atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat     2880

cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc     2940

tcgtttagtg aaccgtcaga tcgcggccgc gccgccacca tggtgagcaa gggcgaggag     3000

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     3060

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     3120

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac     3180

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     3240

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     3300

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     3360

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     3420

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     3480

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     3540

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc     3600

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     3660

gccgggatca ctctcggcat ggacgagctg tacaagtaag ctttatttgt gaaatttgtg     3720

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     3780

gcattcattt tatgtttcag gttcaggggg agatgtggga ggttttttaa agccctgcag     3840

gcaatagcct tgacaaggca accttgacca atagtcttag agtatcaggt gaggccaggg     3900

gccggcggct ggctagggat gaagaataaa aggaagcacc ctccagcagt tccacacact     3960

cgcttctgga acggctgaga ttatcaataa gctcctagtc cagacgccat gggtcatttc     4020

acagaggagg acaaggctac tatcacaagc ctgtggggca aggtgaatgt ggaagatgct     4080

ggaggagaaa ccctgggaag gtaggctctg gtgaccagga caaggaaggg aaggaaggac     4140

cctgtgcctg gcaaaagtcc aggccacttc tcaggatttg tggcactttc tgactgtcaa     4200

actgctcttg ttcaatctca caggctcctg gttgtctacc catggaccca gaggttcttt     4260

gacagctttg gcaacctgtc ctctgcctct gccatcatgg gcaaccccaa ggtcaaggca     4320

cacggcaaga aggtgctgac ttccttggga gatgccataa agaacctgga tgatctcaag     4380

ggcacctttg cccagctgag tgagctgcac tgtgacaagc tgcatgtgga tcctgagaac     4440

ttcagggtga gtccaggagt ttcagcagtt tcagagttca gtctcaaggc gtcgacagga     4500

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     4560

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     4620

gcgcagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag     4680

cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta     4740

ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa     4800

gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca     4860

ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa     4920

tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg     4980

tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     5040

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     5100

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     5160

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     5220

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     5280

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     5340

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     5400

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt     5460

gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt     5520

gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc     5580

aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt     5640

tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc     5700

acccgtttga atctttacct acacattact caggcattgc atttaaaata tatgagggtt     5760

ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc     5820

ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg     5880

ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt     5940

tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg     6000

ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg     6060

acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg     6120

catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat     6180

acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac     6240

ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat     6300

gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag     6360

tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc     6420

tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc     6480

acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc     6540

cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc     6600

ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt     6660

ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt     6720

atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat     6780

cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct     6840

tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat     6900

gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc     6960

ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg     7020

ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc     7080

tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta     7140

cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc     7200

ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga     7260

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     7320

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     7380

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     7440

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     7500

ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt     7560

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     7620

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     7680

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     7740

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     7800

gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     7860

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     7920

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     7980

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat     8040

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc     8100

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga     8160

agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg           8214


<210>  58
<211>  15824
<212>  DNA
<213>  Artificial

<220>
<223>  TALEN plasmid sequence

<400>  58
gcgtataatg gactattgtg tgctgataag gagaacataa gcgcagaaca atatgtatct       60

attccggtgt tgtgttcctt tgttattctg ctattatgtt ctcttatagt gtgacgaaag      120

cagcataatt aatcgccact tgttctttga ttgtgttacg atatccagag acttagaaac      180

gggggaaccg ggatgagcaa ggtaaaaatc ggtgagttga tcaacacgct tgtgaatgag      240

gtagaggcaa ttgatgcctc agaccgccca caaggcgaca aaacgaagag aattaaagcc      300

gcagccgcac ggtataagaa cgcgttattt aatgataaaa gaaagttccg tgggaaagga      360

ttgcagaaaa gaataaccgc gaatactttt aacgcctata tgagcagggc aagaaagcgg      420

tttgatgata aattacatca tagctttgat aaaaatatta ataaattatc ggaaaagtat      480

cctctttaca gcgaagaatt atcttcatgg ctttctatgc ctacggctaa tattcgccag      540

cacatgtcat cgttacaatc taaattgaaa gaaataatgc cgcttgccga agagttatca      600

aatgtaagaa taggctctaa aggcagtgat gcaaaaatag caagactaat aaaaaaatat      660

ccagattgga gttttgctct tagtgattta aacagtgatg attggaagga gcgccgtgac      720

tatctttata agttattcca acaaggctct gcgttgttag aagaactaca ccagctcaag      780

gtcaaccatg aggttctgta ccatctgcag ctaagccctg cggagcgtac atctatacag      840

caacgatggg ccgatgttct gcgcgagaag aagcgtaatg ttgtggttat tgactaccca      900

acatacatgc agtctatcta tgatattttg aataatcctg cgactttatt tagtttaaac      960

actcgttctg gaatggcacc tttggccttt gctctggctg cggtatcagg gcgaagaatg     1020

attgagataa tgtttcaggg tgaatttgcc gtttcaggaa agtatacggt taatttctca     1080

gggcaagcta aaaaacgctc tgaagataaa agcgtaacca gaacgattta tactttatgc     1140

gaagcaaaat tattcgttga attattaaca gaattgcgtt cttgctctgc tgcatctgat     1200

ttcgatgagg ttgttaaagg atatggaaag gatgatacaa ggtctgagaa cggcaggata     1260

aatgctattt tagcaaaagc atttaaccct tgggttaaat catttttcgg cgatgaccgt     1320

cgtgtttata aagatagccg cgctatttac gctcgcatcg cttatgagat gttcttccgc     1380

gtcgatccac ggtggaaaaa cgtcgacgag gatgtgttct tcatggagat tctcggacac     1440

gacgatgaga acacccagct gcactataag cagttcaagc tggccaactt ctccagaacc     1500

tggcgacctg aagttgggga tgaaaacacc aggctggtgg ctctgcagaa actggacgat     1560

gaaatgccag gctttgccag aggtgacgct ggcgtccgtc tgcatgaaac cgttaagcag     1620

ctggtggagc aggacccatc agcaaaaata accaacagca ctctccgggc ctttaaattt     1680

agcccgacga tgattagccg gtacctggag tttgccgctg atgcattggg gcagttcgtt     1740

ggcgagaacg ggcagtggca gctgaagata gagacacctg caatcgtcct gcctgatgaa     1800

gaatccgttg aaaccatcga cgaaccggat gatgagtccc aagacgacga gctggatgaa     1860

gatgaaattg agctcgacga gggtggcggc gatgaaccaa ccgaagagga agggccagaa     1920

gaacatcagc caactgctct aaaacccgtc ttcaagcctg caaaaaataa cggggacgga     1980

acgtacaaga tagagtttga atacgatgga aagcattatg cctggtccgg ccccgccgat     2040

agccctatgg ccgcaatgcg atccgcatgg gaaacgtact acagctaaaa gaaaagccac     2100

cggtgttaat cggtggcttt tttattgagg cctgtcccta cccatcccct gcaagggacg     2160

gaaggattag gcggaaactg cagctgcaac tacggacatc gccgtcccga ctgcagggac     2220

ttccccgcgt aaagcggggc ttaaattcgg gctggccaac cctatttttc tgcaatcgct     2280

ggcgatgtta gtttcgtgga tagcgtttcc agcttttcaa tggccagctc aaaatgtgct     2340

ggcagcacct tctccagttc cgtatcaata tcggtgatcg gcagctctcc acaagacata     2400

ctccggcgac cgccacgaac tacatcgcgc agcagctccc gttcgtagac acgcatgttg     2460

cccagagccg tttctgcagc cgttaatatc cggcgcagct cggcgatgat tgccgggaga     2520

tcatccacgg ttattgggtt cggtgatggg ttcctgcagg cgcggcggag agccatccag     2580

acgccgctaa cccatgcgtt acggtactga aaactttgtg ctatgtcgtt tatcaggccc     2640

cgaagttctt ctttctgccg ccagtccagt ggttcaccgg cgttcttagg ctcaggctcg     2700

acaaaagcat actcgccgtt tttccggata gctggcagaa cctcgttcgt cacccacttg     2760

cggaaccgcc aggctgtcgt cccctgtttc accgcgtcgc ggcagcggag gattatggtg     2820

tagaggccag attccgatac cacatttact tccctggcca tccgatcaag tttttgtgcc     2880

tcggttaaac cgagggtcaa tttttcatca tgatccagct tacgcaatgc atcagaaggg     2940

ttggctatat tcaatgcagc acagatatcc agcgccacaa accacgggtc accaccgaca     3000

agaaccaccc gtatagggtg gctttcctga aatgaaaaga cggagagagc cttcattgcg     3060

cctccccgga tttcagctgc tcagaaaggg acagggagca gccgcgagct tcctgcgtga     3120

gttcgcgcgc gacctgcaga agttccgcag cttcctgcaa atacagcgtg gcctcataac     3180

tggagatagt gcggtgagca gagcccacaa gcgcttcaac ctgcagcagg cgttcctcaa     3240

tcgtcttcag caggccctgg gcgtttaact gaatctggtt catgcgatca cctcgctgac     3300

cgggatacgg gctgacagaa cgaggacaaa acggctggcg aactggcgac gagcttctcg     3360

ctcggatgat gcagtggtgg aaaggcggtg gatatgggat tttttgtccg tgcggacgac     3420

agctgcaaat ttgaatttga acatggtatg cattcctatc ttgtataggg tgctaccacc     3480

agagttgaga atctctatag gggtggtagc ccagacaggg ttctcaacac cggtacaaga     3540

agaaaccggc ccaaccgaag ttggccccat ctgagccacc ataattcagg tatgcgcaga     3600

tttaacacac aaaaaaacac gctggcgcgt gttgtgcgct tcttgtcatt cggggttgag     3660

aggcccggct gcagattttg ctgcagcggg gtaactctac cgccaaagca gaacgcacgt     3720

caataattta ggtggatatt ttaccccgtg accagtcacg tgcacaggtg tttttatagt     3780

ttgctttact gactgatcag aacctgatca gttattggag tccggtaatc ttattgatga     3840

ccgcagccac cttagatgtt gtctcaaacc ccatacggcc acgaatgagc cactggaacg     3900

gaatagtcag caggtacagc ggaacgaacc acaaacggtt cagacgctgc cagaacgtcg     3960

catcacgacg ttccatccat tcggtattgt cgacgacctg gtaagcgtat tgtcctggcg     4020

tttttgctgc ttccgagtag caatcctctt caccacaaag aaagttactt atctgcttcc     4080

agttttcgaa cccttcttct ttgagccgct tttccagctc attcctccac aaaacaggca     4140

cccatcctct gcgataaatc atgattattt gtcctttaaa taaggctgta gaactgcaaa     4200

atcgctctcg ttcacatgct gtacgtagat gcgtagcaaa ttgccgttcc atccctgtaa     4260

tccaccttct ttggaaagat cgtccttgac ctcacgaaga actttatcca atagccctgc     4320

ggcacaagaa attgcctgct ctggatcagc aaattcatat tgattaatag gtgattgcca     4380

cacaccaaaa acaggaatca tcttttcggc taaacgcctc tcctgttctt tcttaatctc     4440

aagttgtaag cggaccagct caccatccat cattttttgt agatcatgcg ccactattca     4500

cccccactgg ccatcagcaa ataaagcttc atactcggac accggcaggc ggcttccacg     4560

gattgaaagg tcaagccaac cacgtccaga tgggtcagcc ttatccgatt cttcccaccg     4620

ttctgcagct gtagcaacca ggcattctac cgccttcatg tagtcttctg tacggaacca     4680

gccgtagtta atgccaccat cagtaactgc ccaggccatc tttttctctt cggcctcaat     4740

agcccggatg cggttatcgc acagctcgcg acagtacttc agctgttcgt aatccagttg     4800

cttcaggaac tctggtgtcg acgtcatagt ggcttcacct tataggcttt tagaagcgcc     4860

ctggcttcgt ctgtgtggtc ttccatgctc ttatcgctgg caatgcagca ataaactccc     4920

tcactatctg agaacccgtt catccgaatg atcgtgaatg gaagttcccg gccagtttta     4980

taatcgctat agcttgtcgc gtcgtggctg accttgacca cataagggtc gtagccctcc     5040

acgatgacaa ggcattcccg ttgttttccc attacccctc cggttatatc gccacggctt     5100

gccgctggct tagaaacgct ttcagcagcc ttatttcgcg tactgatagc aggtccataa     5160

attcggtcat gtacagcgag gcgaacgttc tcgcgatgct ggccactggc cacaggcgta     5220

ccgcctccat ttcggttgct ggcaacgcgt tctccgccca cgcctccggt accgccaccg     5280

ggatagcctc cagtgcctgg ataattactg attgtggggc gtccggaacg tgctctgttt     5340

tggatcgagg gttaccatgt atatctatat ttagatccaa atcgcgatcc acttcgatgg     5400

tggttttttc caccttacgt gcgtgaattg ataaaccggc ctcgcggcgc ttctccacga     5460

tattcatgag gaactcgacc gagtccgggt caatggaacg catcgtgggg cgtgcatcgc     5520

catctctggc gcgtctggtc ttactggata gccccataga ctccaggatg cctatgcaga     5580

ggtctgcagg cgctttcttc ttgcctttct ctgtgttgaa gccgccgatg cgtaaaacgt     5640

tgtttagcag atcgcgccgt tccggcgtga gcaggttatc tctggcgcgt ttgagggcgt     5700

ccatgtctgc ttcaccttcc agggtttttg gatcgatacc gcagtcgcgg aagtactgct     5760

gcagcgtcgc cgatttgagg gtgtagaaac cacgcatgcc tatctcaaca gcaggggtcg     5820

atttcactcg gtaatcggtt atggccggga atttagcctg gaactctgcg tcggcctgtt     5880

cccgcgtcat ggccgtagtg acgaactgct gccatcttcc ggcaacgcga taagcgtagg     5940

taaagtgaat caacgcttct tcacggtcaa ggcgacgggc ggttatctca tccagctgca     6000

tggtttcaaa caggcgcact tttttcaggc cgccgtcgaa atagaatttt aacgccacct     6060

cgtcgacatc cagctgcagc tccttttcga tgtcccagcg gaccagctgg gcctgctcat     6120

ccagggacag ggtgcgtttt tttatcaact catcgtgttc ggcctggtca ggagtatcga     6180

cactcaggtg gcgctccata agctgctcaa agaccagttc acgggcttct ttacgtaaat     6240

ccttaccgat gctgtttgca agcgcgtcgg tggccatagg cgcgacctga tagccatcat     6300

catgcatgat gcaaatcatg ttgctggcat aatcatttct ggccgatgcc tcgagcgcgg     6360

cggctttaat tttgagctgc atgaatgaag agttagccac gccgagtgaa attcggtcac     6420

cgtcaaagac aacgtctgtc agcagcccgg agtggccagc cgtttcgagc aaggcctgcg     6480

cgtaggcgcg tttgattttt tccggatcgg tttcacgttt accgcgaagc ttgtcgaaac     6540

cgataatgta ttcctgagct gtacggtcgc ggcgcagcat ctggatggcg tcgctgggga     6600

ccacttcgcc gcagaacatg ccgaaatggc ggtggaagtg tttctcctca atcgatacac     6660

ctgaagatat cgacgggctg tagatgaggc cgtcatattt tttcaccatc actttaggct     6720

ggttggtgaa atcgtcgact tccttctcct gtttgttttt ctggttaacg cagagaaact     6780

ttttgtcagg gaactgtagt ctcagctgca tggtaacgtc ttcggcgaac gtcgaactgt     6840

cggtggccag catgattcgt tcgccgcgtt gcactgcagc gataacctcg gtcatgatcc     6900

gatttttctc ggtataaaat acgcggatag gcttgttggt ttcgcggttg cgaacgtcga     6960

ccgggagttc aatcacgtga atttgcagcc aggcaggtag gcccagctcc tcgcgtcgct     7020

tcatcgccag ttcagccagg tcaacaagca gatcgttggc atcggcatcc accataatgg     7080

catgctcttc agtacgcgcc agcgcgtcga taagcgtgtt gaatacgcct accgggtttt     7140

ccatcgcacg cccggccaga atggcacgca ggccctgtgt tgcttcatcg aagccgaaga     7200

agtcatgctg gcgcatcagc ggttgccagc agcctttaag tatggagttg atgcaaatag     7260

tcagcttgtt ggcatatggc gccatttcct gatagccggg atcctgataa tgcagaatgt     7320

cggctttcgc gcctttccct tcggtcatca tttcatgcag gccgcctatc agggatacgc     7380

ggtgcgcgac ggaaacgcca cgcgtggact gcagcatcag tggacgcagg aggcctgtcg     7440

atttacccga ccccatcccg gcgcggacaa taacgatgcc ctgcagctgt gcggcgtatg     7500

tcatcacctc atcggtcatc ctggaggttt caaaccgttt gtaagtgatg tgtgacgggc     7560

gaaggttcgg gttggtgatg cgttcactga acgaacgtga tgtttgcgcg gcacggcatt     7620

tgcgattcaa ccggcgcgta atgtgatctt taacggtacc gttataaatt tctgcgatac     7680

ccatatcccg cagcgtgctg ctgaaaaggc gcataagttc tttcgggctg tttggtaccg     7740

ggcatgtcag catgccaata tcaacggcgc gaagcagttc tttggcaaaa gtgcgtctgt     7800

tcagacgcgg gagagtacgc agcttattca gcgtgatcga caacagatcg gttgcacggc     7860

tcagatgatt tctcgttaac tggcgagcga cttccttcag ccctctcagg ctgtgcaggt     7920

cgttaaaatc gctgcattcc agctcagggt catcctcaaa agttgggtaa acacatttga     7980

cgccggaaaa cttctccatg atgtcgaatc cggtgcggag gcctgtgttg ccttttcctt     8040

cagctgagga tttgcggtcg ttatcgagag cgcaagtgat ttgcgcagcc gggtacatgt     8100

tcaccagctg ctcgacaacg tgaatcatgt tgttagcgga aaccgcaatg actaccgcgt     8160

caaagcgttt tttcgggtcg tttctggtcg ccagccagat ggatgccccg gtggcgaaac     8220

cctctgcagt cgcaattttt tgcgccccct gcaggtcgcc aataacaaag catgcaccga     8280

cgaaatcacc gttagtgatg gcgctggtct ggaacttgcc accattcaga tcgatacgtt     8340

gccagccaac aatccgcccg tcttttcttc cgtccaggtg ggacagaggt atcgccatgt     8400

aagttgttgg tccacggctc catttcgcac tgtcgtgact ggtcacgcga cgtatatcac     8460

aagcgccaaa tacgtcacga attccctttt ttaccgcata aggccaggag ccatcttcag     8520

ctggcgaatg ttcccaggcg cgatggaaag ccaaccatcc aagcaggcgt tcctgctcca     8580

tctgattgtt ttttaaatca ttaacgcgtt gttgttcagc tcggaggcgg cgtgcttcag     8640

cctggcgctc catgcgtgca cgttcttctt ccggctgagc gaccacggtc gcaccattcc     8700

gttgctgttc acggcgatac tccgaaaaca ggaatgaaaa gccactccag gagccagcgt     8760

catgcgcttt ttcaacgaag ttaacgaaag gataactgat gccatccttg ctctgctcaa     8820

ggcgtgaata gatttccaca cggcctttaa ggctcttctg cagagcttcc ggggaggaat     8880

tattgtaggt ggtatagcgc tctacaccac cgcgcggatt gagctgaatc ttatcagcac     8940

acgcaggcca gttgataccg gccatcttcg ccagctcagt cagctcatca cgtgccgcgt     9000

caagcagtga aaacggatcg ctgccaaagc gctccgcgta gaattcttgt aaggtcattt     9060

tttagccttt ccatgcgaat tagcattttt tcgggttgaa aaaatccgca ggagcagcca     9120

caataaacgc actatctttc tgaaggacgt atctgcgtta tcgtggctac ttcctgaaaa     9180

aggcccgagt ttgccgactc ggtttttttt tcgtcttttt tcggctgcta cggtctggtt     9240

caaccccgac aaagtataga tcggattaaa ccagaattat agtcagcaat aaaccctgtt     9300

attgtatcat ctaccctcaa ccatgaacga tttgatcgta ccgactactt ggtgcacaaa     9360

ttgaagatca cttttatcat ggataacccg ttgagagtta gcactatcaa ggtagtaatg     9420

ctgctcgtca taacgggcta atcgttgaat tgtgatctcg ccgttattat cacaaaccag     9480

tacatcctca cccggtacaa gcgtaagtga agaatcgacc aggataacat ctcccggctg     9540

gtagtttcgc tgaatctggt tcccgaccgt cagtgcgtaa acggtgttcc gttgactcac     9600

gaacggcagg aatcgctctg tgttggcagg ttctccaggc tgccagtctc tatccggtcc     9660

tgtctctgtc gtaccaataa caggaacgcg gtctggatca gattcagtgc catacagtat     9720

ccattgcacg ggcttacgca ggcattttgc cagcgatagc ccgatctcca gcgacggcat     9780

cacgtcgcca cgttctaagt tttggacgcc cggaagagag attcctacag cttctgccac     9840

ttgcttcagc gtcagtttca gctctaaacg gcgtgctttc agtcgttcgc ctcgtgtttt     9900

cataccctta atcataaatg atctctttat agctggctat aatttttata aattatacct     9960

agctttaatt ttcacttatt gattataata atccccatga aacccgaaga acttgtgcgc    10020

catttcggcg atgtggaaaa agcagcggtt ggcgtgggcg tgacacccgg cgcagtctat    10080

caatggctgc aagctgggga gattccacct ctacgacaaa gcgatataga ggtccgtacc    10140

gcgtacaaat taaagagtga tttcacctct cagcgcatgg gtaaggaagg gcataacaag    10200

gggatcctct agacgcagaa aggcccaccc gaaggtgagc cagtgtgatt acatttgcgg    10260

cctaactgtg gccagtccag ttacgctgga gtcactagtg cggccgcgac aacttgtcta    10320

gggcccaatg gcccatacac ttagtgtaat acgactcact atagggagag cggccgcttt    10380

ttcagcaaga ttaagccgcc accatggcgc cgcggcctcc taagaagaag cggaaagtcg    10440

aattcgtgga tctgcgaaca ctgggctata gccagcagca gcaggagaag atcaaaccca    10500

aggtgaggtc cacagtcgca cagcaccatg aagccctggt gggccacggg ttcactcacg    10560

ctcatattgt cgcactgtct cagcatccag ccgctctggg aaccgtggca gtcacatacc    10620

agcacatcat tactgccctg cccgaggcta cccatgaaga catcgtggga gtcggcaaac    10680

agtggagcgg cgcacgggcc ctggaggctc tgctgaccga cgcaggggaa ctgagaggac    10740

cccctctgca gctggataca gggcagctgg tgaagattgc taagagggga ggggtgacag    10800

caatggaagc cgtccacgca agcaggaacg cactgacagg ggcccccctg aacctgaccc    10860

cggaccaagt ggtggctatc gccagcaatc acggcggcaa gcaagcgctc gaaacggtgc    10920

agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa gtggtggcta    10980

tcgccagcaa tcacggcggc aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc    11040

tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc aatcacggcg    11100

gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag gaccatggcc    11160

tgaccccgga ccaagtggtg gctatcgcca gcaacggtgg cggcaagcaa gcgctcgaaa    11220

cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg    11280

tggctatcgc cagcaacggt ggcggcaagc aagcgctcga aacggtgcag cggctgttgc    11340

cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc gccagcaatc    11400

acggtggaaa acaggccctt gaaacggtgc agcggctgtt gccggtgctg tgccaggacc    11460

atggcctgac cccggaccaa gtggtggcta tcgccagcaa tcacggcggc aagcaagcgc    11520

tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg actccggacc    11580

aagtggtggc tatcgccagc cacgatggcg gcaagcaagc gctcgaaacg gtgcagcggc    11640

tgttgccggt gctgtgccag gaccatggcc tgactccgga ccaagtggtg gctatcgcca    11700

gccacgatgg cggcaagcaa gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc    11760

aggaccatgg cctgaccccg gaccaagtgg tggctatcgc cagcaacatt ggcggcaagc    11820

aagcgctcga aacggtgcag cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc    11880

cggaccaagt ggtggctatc gccagcaatc acggcggcaa gcaagcgctc gaaacggtgc    11940

agcggctgtt gccggtgctg tgccaggacc atggcctgac tccggaccaa gtggtggcta    12000

tcgccagcca cgatggcggc aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc    12060

tgtgccagga ccatggcctg actccggacc aagtggtggc tatcgccagc cacgatggcg    12120

gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag gaccatggcc    12180

tgaccccgga ccaagtggtg gctatcgcca gcaacggtgg cggcaagcaa gcgctcgaaa    12240

cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg    12300

tggctatcgc cagcaacggt ggcggcaagc aagcgctcga aacggtgcag cggctgttgc    12360

cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc gccagcaatc    12420

acggcggcaa gcaagcgctc gaaagcattg tggcccagct gagccggcct gatccggcgt    12480

tggccgcgtt gaccaacgac cacctggtcg ctctggcttg cctgggagga cgccctgcta    12540

tggacgctgt gaagaaagga ctgccccacg cacccgaact gattagacgg gtgaaccgga    12600

gaatcggcga gagaacatcc catagggtgg caatctctag aactcagctg gtcaagagtg    12660

aactggagga aaagaaatca gagctgcgcc acaagctgaa atacgtgcct catgagtata    12720

tcgaactgat cgagattgct cgcaattcaa cccaggaccg gatcctggaa atgaaagtga    12780

tggagttctt tatgaaagtc tacggatatc gggggaaaca cctgggaggg agcagaaagc    12840

cagatggggc catctacaca gtgggatccc ccatcgacta tggcgtgatt gtcgatacta    12900

aagcctacag cggaggctat aacctgccta tcggccaggc tgacgagatg cagagatacg    12960

tggaggaaaa ccagacccgc aataagcata ttaaccccaa tgaatggtgg aaagtgtatc    13020

ctagctccgt cacagagttc aagtttctgt tcgtgagcgg acactttaag ggcaactaca    13080

aagcacagct gactaggctg aatcatatca ccaactgcaa tggagccgtg ctgtctgtcg    13140

aggaactgct gatcggggga gagatgatta aggctggcac actgactctg gaggaagtga    13200

ggcgcaagtt caacaatggg gaaatcaact tctaacctgc aggatgataa gctagccccg    13260

ggcgtacgga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaacgagac cttagggcca ttagacttga    13620

agtcaagcgg ccgcttacaa ctggaccttg ctggtacata gaactgatta actgaccatt    13680

taaatcatac caacatggtc aaataaaacg aaaggctcag tcgaaagact gggcctttcg    13740

ttttaatctg atcggcacgt aagaggttcc aactttcacc ataatgaaat aagatcacta    13800

ccgggcgtat tttgagttat cgagattttc aggagctaag gaagctaaaa tgagccatat    13860

tcaacgggaa acgtcttgct cgaggccgcg attaaattcc aacatggatg ctgatttata    13920

tgggtataaa tgggctcgcg ataatgtcgg gcaatcaggt gcgacaatct atcgattgta    13980

tgggaagccc gatgcgccag agttgtttct gaaacatggc aaaggtagcg ttgccaatga    14040

tgttacagat gagatggtca ggctaaactg gctgacggaa tttatgcctc ttccgaccat    14100

caagcatttt atccgtactc ctgatgatgc atggttactc accactgcga tcccagggaa    14160

aacagcattc caggtattag aagaatatcc tgattcaggt gaaaatattg ttgatgcgct    14220

ggcagtgttc ctgcgccggt tgcattcgat tcctgtttgt aattgtcctt ttaacggcga    14280

tcgcgtattt cgtctggctc aggcgcaatc acgaatgaat aacggtttgg ttggtgcgag    14340

tgattttgat gacgagcgta atggctggcc tgttgaacaa gtctggaaag aaatgcataa    14400

acttttgcca ttctcaccgg attcagtcgt cactcatggt gatttctcac ttgataacct    14460

tatttttgac gaggggaaat taataggttg tattgatgtt ggacgagtcg gaatcgcaga    14520

ccgataccag gatcttgcca tcctatggaa ctgcctcggt gagttttctc cttcattaca    14580

gaaacggctt tttcaaaaat atggtattga taatcctgat atgaataaat tgcagtttca    14640

cttgatgctc gatgagtttt tctaacctag gtgacagaag tcaaaagcct ccggtcggag    14700

gcttttgact ttctgctaga tctgtttcaa tgcggtgaag ggccaggcag ctggggatta    14760

tgtccagacc cggccagcat gttggtttta tcgcatattc agcgttgtcg cgtttaccca    14820

ggtaaaatgg aagcagtgta tcgtctgcgt gaatgtgcaa atcaggaacg taaccgtggt    14880

acatagatgc agtcccttgc gggtcgttcc cttcaacgag taggacgcgg tgcccttgca    14940

aggctaacca ttgcgcctgg tgtactgcag atgaggtttt ataaacccct cccttgtgtg    15000

acataacgga aagtacaacc gggtttttat cgtcaggtct ttggtttggg ttaccaaaca    15060

cactccgcat atggctaatt tggtcaattg tgtagccagc gcgacgttct actcggcccc    15120

tcatctcaaa atcaggagcc ggtagacgac cagctttttc cgcatctctg atagcctgcg    15180

gtgttacgcc gatcaggtct gcaacttctg ttatacccca gcggcgagta atacgacgcg    15240

cttccgggct gtcatcgccg aactgtgcga tggcaatagc gcgcgtcatt tcctgaccgc    15300

gattgataca gtctttcagc aaattaatta acgacatcct gtttcctctc aaacatgccc    15360

ttatctttgt gtttttcatc atactttacg tttttaaagc aaagcaacat aaaaaaagca    15420

aagtgactta gaaaacgcaa agttaaggtt caaatcaatt ttttgatgcg ctacagaagc    15480

tatttagctt catctaagcg caacggtatt acttacgttg gtatatttaa aacctaactt    15540

aatgatttta aatgataata aatcatacca attgctatca aaagttaagc gaacatgctg    15600

attttcacgc tgtttataca ctttgaggca tctctatctc ttctgtctct atattgaaac    15660

acaatcaaag aacatcaatc catgtgacat cccccactat ctaagaacac cataacagaa    15720

cacaacatag gaatgcaaca ttaatgtatc aataattcgg aacatatgca ctatatcata    15780

tctcaattac ggaacatatc agcacacaat tgcccattat acgc                     15824


<210>  59
<211>  16028
<212>  DNA
<213>  Artificial

<220>
<223>  TALEN plasmid sequence

<400>  59
gcgtataatg gactattgtg tgctgataag gagaacataa gcgcagaaca atatgtatct       60

attccggtgt tgtgttcctt tgttattctg ctattatgtt ctcttatagt gtgacgaaag      120

cagcataatt aatcgccact tgttctttga ttgtgttacg atatccagag acttagaaac      180

gggggaaccg ggatgagcaa ggtaaaaatc ggtgagttga tcaacacgct tgtgaatgag      240

gtagaggcaa ttgatgcctc agaccgccca caaggcgaca aaacgaagag aattaaagcc      300

gcagccgcac ggtataagaa cgcgttattt aatgataaaa gaaagttccg tgggaaagga      360

ttgcagaaaa gaataaccgc gaatactttt aacgcctata tgagcagggc aagaaagcgg      420

tttgatgata aattacatca tagctttgat aaaaatatta ataaattatc ggaaaagtat      480

cctctttaca gcgaagaatt atcttcatgg ctttctatgc ctacggctaa tattcgccag      540

cacatgtcat cgttacaatc taaattgaaa gaaataatgc cgcttgccga agagttatca      600

aatgtaagaa taggctctaa aggcagtgat gcaaaaatag caagactaat aaaaaaatat      660

ccagattgga gttttgctct tagtgattta aacagtgatg attggaagga gcgccgtgac      720

tatctttata agttattcca acaaggctct gcgttgttag aagaactaca ccagctcaag      780

gtcaaccatg aggttctgta ccatctgcag ctaagccctg cggagcgtac atctatacag      840

caacgatggg ccgatgttct gcgcgagaag aagcgtaatg ttgtggttat tgactaccca      900

acatacatgc agtctatcta tgatattttg aataatcctg cgactttatt tagtttaaac      960

actcgttctg gaatggcacc tttggccttt gctctggctg cggtatcagg gcgaagaatg     1020

attgagataa tgtttcaggg tgaatttgcc gtttcaggaa agtatacggt taatttctca     1080

gggcaagcta aaaaacgctc tgaagataaa agcgtaacca gaacgattta tactttatgc     1140

gaagcaaaat tattcgttga attattaaca gaattgcgtt cttgctctgc tgcatctgat     1200

ttcgatgagg ttgttaaagg atatggaaag gatgatacaa ggtctgagaa cggcaggata     1260

aatgctattt tagcaaaagc atttaaccct tgggttaaat catttttcgg cgatgaccgt     1320

cgtgtttata aagatagccg cgctatttac gctcgcatcg cttatgagat gttcttccgc     1380

gtcgatccac ggtggaaaaa cgtcgacgag gatgtgttct tcatggagat tctcggacac     1440

gacgatgaga acacccagct gcactataag cagttcaagc tggccaactt ctccagaacc     1500

tggcgacctg aagttgggga tgaaaacacc aggctggtgg ctctgcagaa actggacgat     1560

gaaatgccag gctttgccag aggtgacgct ggcgtccgtc tgcatgaaac cgttaagcag     1620

ctggtggagc aggacccatc agcaaaaata accaacagca ctctccgggc ctttaaattt     1680

agcccgacga tgattagccg gtacctggag tttgccgctg atgcattggg gcagttcgtt     1740

ggcgagaacg ggcagtggca gctgaagata gagacacctg caatcgtcct gcctgatgaa     1800

gaatccgttg aaaccatcga cgaaccggat gatgagtccc aagacgacga gctggatgaa     1860

gatgaaattg agctcgacga gggtggcggc gatgaaccaa ccgaagagga agggccagaa     1920

gaacatcagc caactgctct aaaacccgtc ttcaagcctg caaaaaataa cggggacgga     1980

acgtacaaga tagagtttga atacgatgga aagcattatg cctggtccgg ccccgccgat     2040

agccctatgg ccgcaatgcg atccgcatgg gaaacgtact acagctaaaa gaaaagccac     2100

cggtgttaat cggtggcttt tttattgagg cctgtcccta cccatcccct gcaagggacg     2160

gaaggattag gcggaaactg cagctgcaac tacggacatc gccgtcccga ctgcagggac     2220

ttccccgcgt aaagcggggc ttaaattcgg gctggccaac cctatttttc tgcaatcgct     2280

ggcgatgtta gtttcgtgga tagcgtttcc agcttttcaa tggccagctc aaaatgtgct     2340

ggcagcacct tctccagttc cgtatcaata tcggtgatcg gcagctctcc acaagacata     2400

ctccggcgac cgccacgaac tacatcgcgc agcagctccc gttcgtagac acgcatgttg     2460

cccagagccg tttctgcagc cgttaatatc cggcgcagct cggcgatgat tgccgggaga     2520

tcatccacgg ttattgggtt cggtgatggg ttcctgcagg cgcggcggag agccatccag     2580

acgccgctaa cccatgcgtt acggtactga aaactttgtg ctatgtcgtt tatcaggccc     2640

cgaagttctt ctttctgccg ccagtccagt ggttcaccgg cgttcttagg ctcaggctcg     2700

acaaaagcat actcgccgtt tttccggata gctggcagaa cctcgttcgt cacccacttg     2760

cggaaccgcc aggctgtcgt cccctgtttc accgcgtcgc ggcagcggag gattatggtg     2820

tagaggccag attccgatac cacatttact tccctggcca tccgatcaag tttttgtgcc     2880

tcggttaaac cgagggtcaa tttttcatca tgatccagct tacgcaatgc atcagaaggg     2940

ttggctatat tcaatgcagc acagatatcc agcgccacaa accacgggtc accaccgaca     3000

agaaccaccc gtatagggtg gctttcctga aatgaaaaga cggagagagc cttcattgcg     3060

cctccccgga tttcagctgc tcagaaaggg acagggagca gccgcgagct tcctgcgtga     3120

gttcgcgcgc gacctgcaga agttccgcag cttcctgcaa atacagcgtg gcctcataac     3180

tggagatagt gcggtgagca gagcccacaa gcgcttcaac ctgcagcagg cgttcctcaa     3240

tcgtcttcag caggccctgg gcgtttaact gaatctggtt catgcgatca cctcgctgac     3300

cgggatacgg gctgacagaa cgaggacaaa acggctggcg aactggcgac gagcttctcg     3360

ctcggatgat gcagtggtgg aaaggcggtg gatatgggat tttttgtccg tgcggacgac     3420

agctgcaaat ttgaatttga acatggtatg cattcctatc ttgtataggg tgctaccacc     3480

agagttgaga atctctatag gggtggtagc ccagacaggg ttctcaacac cggtacaaga     3540

agaaaccggc ccaaccgaag ttggccccat ctgagccacc ataattcagg tatgcgcaga     3600

tttaacacac aaaaaaacac gctggcgcgt gttgtgcgct tcttgtcatt cggggttgag     3660

aggcccggct gcagattttg ctgcagcggg gtaactctac cgccaaagca gaacgcacgt     3720

caataattta ggtggatatt ttaccccgtg accagtcacg tgcacaggtg tttttatagt     3780

ttgctttact gactgatcag aacctgatca gttattggag tccggtaatc ttattgatga     3840

ccgcagccac cttagatgtt gtctcaaacc ccatacggcc acgaatgagc cactggaacg     3900

gaatagtcag caggtacagc ggaacgaacc acaaacggtt cagacgctgc cagaacgtcg     3960

catcacgacg ttccatccat tcggtattgt cgacgacctg gtaagcgtat tgtcctggcg     4020

tttttgctgc ttccgagtag caatcctctt caccacaaag aaagttactt atctgcttcc     4080

agttttcgaa cccttcttct ttgagccgct tttccagctc attcctccac aaaacaggca     4140

cccatcctct gcgataaatc atgattattt gtcctttaaa taaggctgta gaactgcaaa     4200

atcgctctcg ttcacatgct gtacgtagat gcgtagcaaa ttgccgttcc atccctgtaa     4260

tccaccttct ttggaaagat cgtccttgac ctcacgaaga actttatcca atagccctgc     4320

ggcacaagaa attgcctgct ctggatcagc aaattcatat tgattaatag gtgattgcca     4380

cacaccaaaa acaggaatca tcttttcggc taaacgcctc tcctgttctt tcttaatctc     4440

aagttgtaag cggaccagct caccatccat cattttttgt agatcatgcg ccactattca     4500

cccccactgg ccatcagcaa ataaagcttc atactcggac accggcaggc ggcttccacg     4560

gattgaaagg tcaagccaac cacgtccaga tgggtcagcc ttatccgatt cttcccaccg     4620

ttctgcagct gtagcaacca ggcattctac cgccttcatg tagtcttctg tacggaacca     4680

gccgtagtta atgccaccat cagtaactgc ccaggccatc tttttctctt cggcctcaat     4740

agcccggatg cggttatcgc acagctcgcg acagtacttc agctgttcgt aatccagttg     4800

cttcaggaac tctggtgtcg acgtcatagt ggcttcacct tataggcttt tagaagcgcc     4860

ctggcttcgt ctgtgtggtc ttccatgctc ttatcgctgg caatgcagca ataaactccc     4920

tcactatctg agaacccgtt catccgaatg atcgtgaatg gaagttcccg gccagtttta     4980

taatcgctat agcttgtcgc gtcgtggctg accttgacca cataagggtc gtagccctcc     5040

acgatgacaa ggcattcccg ttgttttccc attacccctc cggttatatc gccacggctt     5100

gccgctggct tagaaacgct ttcagcagcc ttatttcgcg tactgatagc aggtccataa     5160

attcggtcat gtacagcgag gcgaacgttc tcgcgatgct ggccactggc cacaggcgta     5220

ccgcctccat ttcggttgct ggcaacgcgt tctccgccca cgcctccggt accgccaccg     5280

ggatagcctc cagtgcctgg ataattactg attgtggggc gtccggaacg tgctctgttt     5340

tggatcgagg gttaccatgt atatctatat ttagatccaa atcgcgatcc acttcgatgg     5400

tggttttttc caccttacgt gcgtgaattg ataaaccggc ctcgcggcgc ttctccacga     5460

tattcatgag gaactcgacc gagtccgggt caatggaacg catcgtgggg cgtgcatcgc     5520

catctctggc gcgtctggtc ttactggata gccccataga ctccaggatg cctatgcaga     5580

ggtctgcagg cgctttcttc ttgcctttct ctgtgttgaa gccgccgatg cgtaaaacgt     5640

tgtttagcag atcgcgccgt tccggcgtga gcaggttatc tctggcgcgt ttgagggcgt     5700

ccatgtctgc ttcaccttcc agggtttttg gatcgatacc gcagtcgcgg aagtactgct     5760

gcagcgtcgc cgatttgagg gtgtagaaac cacgcatgcc tatctcaaca gcaggggtcg     5820

atttcactcg gtaatcggtt atggccggga atttagcctg gaactctgcg tcggcctgtt     5880

cccgcgtcat ggccgtagtg acgaactgct gccatcttcc ggcaacgcga taagcgtagg     5940

taaagtgaat caacgcttct tcacggtcaa ggcgacgggc ggttatctca tccagctgca     6000

tggtttcaaa caggcgcact tttttcaggc cgccgtcgaa atagaatttt aacgccacct     6060

cgtcgacatc cagctgcagc tccttttcga tgtcccagcg gaccagctgg gcctgctcat     6120

ccagggacag ggtgcgtttt tttatcaact catcgtgttc ggcctggtca ggagtatcga     6180

cactcaggtg gcgctccata agctgctcaa agaccagttc acgggcttct ttacgtaaat     6240

ccttaccgat gctgtttgca agcgcgtcgg tggccatagg cgcgacctga tagccatcat     6300

catgcatgat gcaaatcatg ttgctggcat aatcatttct ggccgatgcc tcgagcgcgg     6360

cggctttaat tttgagctgc atgaatgaag agttagccac gccgagtgaa attcggtcac     6420

cgtcaaagac aacgtctgtc agcagcccgg agtggccagc cgtttcgagc aaggcctgcg     6480

cgtaggcgcg tttgattttt tccggatcgg tttcacgttt accgcgaagc ttgtcgaaac     6540

cgataatgta ttcctgagct gtacggtcgc ggcgcagcat ctggatggcg tcgctgggga     6600

ccacttcgcc gcagaacatg ccgaaatggc ggtggaagtg tttctcctca atcgatacac     6660

ctgaagatat cgacgggctg tagatgaggc cgtcatattt tttcaccatc actttaggct     6720

ggttggtgaa atcgtcgact tccttctcct gtttgttttt ctggttaacg cagagaaact     6780

ttttgtcagg gaactgtagt ctcagctgca tggtaacgtc ttcggcgaac gtcgaactgt     6840

cggtggccag catgattcgt tcgccgcgtt gcactgcagc gataacctcg gtcatgatcc     6900

gatttttctc ggtataaaat acgcggatag gcttgttggt ttcgcggttg cgaacgtcga     6960

ccgggagttc aatcacgtga atttgcagcc aggcaggtag gcccagctcc tcgcgtcgct     7020

tcatcgccag ttcagccagg tcaacaagca gatcgttggc atcggcatcc accataatgg     7080

catgctcttc agtacgcgcc agcgcgtcga taagcgtgtt gaatacgcct accgggtttt     7140

ccatcgcacg cccggccaga atggcacgca ggccctgtgt tgcttcatcg aagccgaaga     7200

agtcatgctg gcgcatcagc ggttgccagc agcctttaag tatggagttg atgcaaatag     7260

tcagcttgtt ggcatatggc gccatttcct gatagccggg atcctgataa tgcagaatgt     7320

cggctttcgc gcctttccct tcggtcatca tttcatgcag gccgcctatc agggatacgc     7380

ggtgcgcgac ggaaacgcca cgcgtggact gcagcatcag tggacgcagg aggcctgtcg     7440

atttacccga ccccatcccg gcgcggacaa taacgatgcc ctgcagctgt gcggcgtatg     7500

tcatcacctc atcggtcatc ctggaggttt caaaccgttt gtaagtgatg tgtgacgggc     7560

gaaggttcgg gttggtgatg cgttcactga acgaacgtga tgtttgcgcg gcacggcatt     7620

tgcgattcaa ccggcgcgta atgtgatctt taacggtacc gttataaatt tctgcgatac     7680

ccatatcccg cagcgtgctg ctgaaaaggc gcataagttc tttcgggctg tttggtaccg     7740

ggcatgtcag catgccaata tcaacggcgc gaagcagttc tttggcaaaa gtgcgtctgt     7800

tcagacgcgg gagagtacgc agcttattca gcgtgatcga caacagatcg gttgcacggc     7860

tcagatgatt tctcgttaac tggcgagcga cttccttcag ccctctcagg ctgtgcaggt     7920

cgttaaaatc gctgcattcc agctcagggt catcctcaaa agttgggtaa acacatttga     7980

cgccggaaaa cttctccatg atgtcgaatc cggtgcggag gcctgtgttg ccttttcctt     8040

cagctgagga tttgcggtcg ttatcgagag cgcaagtgat ttgcgcagcc gggtacatgt     8100

tcaccagctg ctcgacaacg tgaatcatgt tgttagcgga aaccgcaatg actaccgcgt     8160

caaagcgttt tttcgggtcg tttctggtcg ccagccagat ggatgccccg gtggcgaaac     8220

cctctgcagt cgcaattttt tgcgccccct gcaggtcgcc aataacaaag catgcaccga     8280

cgaaatcacc gttagtgatg gcgctggtct ggaacttgcc accattcaga tcgatacgtt     8340

gccagccaac aatccgcccg tcttttcttc cgtccaggtg ggacagaggt atcgccatgt     8400

aagttgttgg tccacggctc catttcgcac tgtcgtgact ggtcacgcga cgtatatcac     8460

aagcgccaaa tacgtcacga attccctttt ttaccgcata aggccaggag ccatcttcag     8520

ctggcgaatg ttcccaggcg cgatggaaag ccaaccatcc aagcaggcgt tcctgctcca     8580

tctgattgtt ttttaaatca ttaacgcgtt gttgttcagc tcggaggcgg cgtgcttcag     8640

cctggcgctc catgcgtgca cgttcttctt ccggctgagc gaccacggtc gcaccattcc     8700

gttgctgttc acggcgatac tccgaaaaca ggaatgaaaa gccactccag gagccagcgt     8760

catgcgcttt ttcaacgaag ttaacgaaag gataactgat gccatccttg ctctgctcaa     8820

ggcgtgaata gatttccaca cggcctttaa ggctcttctg cagagcttcc ggggaggaat     8880

tattgtaggt ggtatagcgc tctacaccac cgcgcggatt gagctgaatc ttatcagcac     8940

acgcaggcca gttgataccg gccatcttcg ccagctcagt cagctcatca cgtgccgcgt     9000

caagcagtga aaacggatcg ctgccaaagc gctccgcgta gaattcttgt aaggtcattt     9060

tttagccttt ccatgcgaat tagcattttt tcgggttgaa aaaatccgca ggagcagcca     9120

caataaacgc actatctttc tgaaggacgt atctgcgtta tcgtggctac ttcctgaaaa     9180

aggcccgagt ttgccgactc ggtttttttt tcgtcttttt tcggctgcta cggtctggtt     9240

caaccccgac aaagtataga tcggattaaa ccagaattat agtcagcaat aaaccctgtt     9300

attgtatcat ctaccctcaa ccatgaacga tttgatcgta ccgactactt ggtgcacaaa     9360

ttgaagatca cttttatcat ggataacccg ttgagagtta gcactatcaa ggtagtaatg     9420

ctgctcgtca taacgggcta atcgttgaat tgtgatctcg ccgttattat cacaaaccag     9480

tacatcctca cccggtacaa gcgtaagtga agaatcgacc aggataacat ctcccggctg     9540

gtagtttcgc tgaatctggt tcccgaccgt cagtgcgtaa acggtgttcc gttgactcac     9600

gaacggcagg aatcgctctg tgttggcagg ttctccaggc tgccagtctc tatccggtcc     9660

tgtctctgtc gtaccaataa caggaacgcg gtctggatca gattcagtgc catacagtat     9720

ccattgcacg ggcttacgca ggcattttgc cagcgatagc ccgatctcca gcgacggcat     9780

cacgtcgcca cgttctaagt tttggacgcc cggaagagag attcctacag cttctgccac     9840

ttgcttcagc gtcagtttca gctctaaacg gcgtgctttc agtcgttcgc ctcgtgtttt     9900

cataccctta atcataaatg atctctttat agctggctat aatttttata aattatacct     9960

agctttaatt ttcacttatt gattataata atccccatga aacccgaaga acttgtgcgc    10020

catttcggcg atgtggaaaa agcagcggtt ggcgtgggcg tgacacccgg cgcagtctat    10080

caatggctgc aagctgggga gattccacct ctacgacaaa gcgatataga ggtccgtacc    10140

gcgtacaaat taaagagtga tttcacctct cagcgcatgg gtaaggaagg gcataacaag    10200

gggatcctct agacgcagaa aggcccaccc gaaggtgagc cagtgtgatt acatttgcgg    10260

cctaactgtg gccagtccag ttacgctgga gtcactagtg cggccgcgac aacttgtcta    10320

gggcccaatg gcccatacac ttagtgtaat acgactcact atagggagag cggccgcttt    10380

ttcagcaaga ttaagccgcc accatggcgc cgcggcctcc taagaagaag cggaaagtcg    10440

aattcgtgga tctgcgaaca ctgggctata gccagcagca gcaggagaag atcaaaccca    10500

aggtgaggtc cacagtcgca cagcaccatg aagccctggt gggccacggg ttcactcacg    10560

ctcatattgt cgcactgtct cagcatccag ccgctctggg aaccgtggca gtcacatacc    10620

agcacatcat tactgccctg cccgaggcta cccatgaaga catcgtggga gtcggcaaac    10680

agtggagcgg cgcacgggcc ctggaggctc tgctgaccga cgcaggggaa ctgagaggac    10740

cccctctgca gctggataca gggcagctgg tgaagattgc taagagggga ggggtgacag    10800

caatggaagc cgtccacgca agcaggaacg cactgacagg ggcccccctg aacctgaccc    10860

cggaccaagt ggtggctatc gccagcaatc acggcggcaa gcaagcgctc gaaacggtgc    10920

agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa gtggtggcta    10980

tcgccagcaa tcacggcggc aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc    11040

tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc aacggtggcg    11100

gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag gaccatggcc    11160

tgactccgga ccaagtggtg gctatcgcca gccacgatgg cggcaagcaa gcgctcgaaa    11220

cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg    11280

tggctatcgc cagcaacatt ggcggcaagc aagcgctcga aacggtgcag cggctgttgc    11340

cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc gccagcaaca    11400

ttggtggaaa acaggccctt gaaacggtgc agcggctgtt gccggtgctg tgccaggacc    11460

atggcctgac cccggaccaa gtggtggcta tcgccagcaa tcacggcggc aagcaagcgc    11520

tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg accccggacc    11580

aagtggtggc tatcgccagc aacggtggcg gcaagcaagc gctcgaaacg gtgcagcggc    11640

tgttgccggt gctgtgccag gaccatggcc tgaccccgga ccaagtggtg gctatcgcca    11700

gcaacggtgg cggcaagcaa gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc    11760

aggaccatgg cctgaccccg gaccaagtgg tggctatcgc cagcaacggt ggcggcaagc    11820

aagcgctcga aacggtgcag cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc    11880

cggaccaagt ggtggctatc gccagcaatc acggcggcaa gcaagcgctc gaaacggtgc    11940

agcggctgtt gccggtgctg tgccaggacc atggcctgac tccggaccaa gtggtggcta    12000

tcgccagcca cgatggcggc aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc    12060

tgtgccagga ccatggcctg actccggacc aagtggtggc tatcgccagc cacgatggcg    12120

gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag gaccatggcc    12180

tgaccccgga ccaagtggtg gctatcgcca gcaacggtgg cggcaagcaa gcgctcgaaa    12240

cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg    12300

tggctatcgc cagcaacggt ggcggcaagc aagcgctcga aacggtgcag cggctgttgc    12360

cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc gccagcaatc    12420

acggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg tgccaggacc    12480

atggcctgac cccggaccaa gtggtggcta tcgccagcaa cggtggcggc aagcaagcgc    12540

tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg accccggacc    12600

aagtggtggc tatcgccagc cacgatggcg gcaagcaagc gctcgaaagc attgtggccc    12660

agctgagccg gcctgatccg gcgttggccg cgttgaccaa cgaccacctg gtcgctctgg    12720

cttgcctggg aggacgccct gctatggacg ctgtgaagaa aggactgccc cacgcacccg    12780

aactgattag acgggtgaac cggagaatcg gcgagagaac atcccatagg gtggcaatct    12840

ctagaactca gctggtcaag agtgaactgg aggaaaagaa atcagagctg cgccacaagc    12900

tgaaatacgt gcctcatgag tatatcgaac tgatcgagat tgctcgcaat tcaacccagg    12960

accggatcct ggaaatgaaa gtgatggagt tctttatgaa agtctacgga tatcggggga    13020

aacacctggg agggagcaga aagccagatg gggccatcta cacagtggga tcccccatcg    13080

actatggcgt gattgtcgat actaaagcct acagcggagg ctataacctg cctatcggcc    13140

aggctgacga gatgcagaga tacgtggagg aaaaccagac ccgcaataag catattaacc    13200

ccaatgaatg gtggaaagtg tatcctagct ccgtcacaga gttcaagttt ctgttcgtga    13260

gcggacactt taagggcaac tacaaagcac agctgactag gctgaatcat atcaccaact    13320

gcaatggagc cgtgctgtct gtcgaggaac tgctgatcgg gggagagatg attaaggctg    13380

gcacactgac tctggaggaa gtgaggcgca agttcaacaa tggggaaatc aacttctaac    13440

ctgcaggatg ataagctagc cccgggcgta cggaaaaaaa aaaaaaaaaa aaaaaaaaaa    13500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    13740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaacg    13800

agaccttagg gccattagac ttgaagtcaa gcggccgctt acaactggac cttgctggta    13860

catagaactg attaactgac catttaaatc ataccaacat ggtcaaataa aacgaaaggc    13920

tcagtcgaaa gactgggcct ttcgttttaa tctgatcggc acgtaagagg ttccaacttt    13980

caccataatg aaataagatc actaccgggc gtattttgag ttatcgagat tttcaggagc    14040

taaggaagct aaaatgagcc atattcaacg ggaaacgtct tgctcgaggc cgcgattaaa    14100

ttccaacatg gatgctgatt tatatgggta taaatgggct cgcgataatg tcgggcaatc    14160

aggtgcgaca atctatcgat tgtatgggaa gcccgatgcg ccagagttgt ttctgaaaca    14220

tggcaaaggt agcgttgcca atgatgttac agatgagatg gtcaggctaa actggctgac    14280

ggaatttatg cctcttccga ccatcaagca ttttatccgt actcctgatg atgcatggtt    14340

actcaccact gcgatcccag ggaaaacagc attccaggta ttagaagaat atcctgattc    14400

aggtgaaaat attgttgatg cgctggcagt gttcctgcgc cggttgcatt cgattcctgt    14460

ttgtaattgt ccttttaacg gcgatcgcgt atttcgtctg gctcaggcgc aatcacgaat    14520

gaataacggt ttggttggtg cgagtgattt tgatgacgag cgtaatggct ggcctgttga    14580

acaagtctgg aaagaaatgc ataaactttt gccattctca ccggattcag tcgtcactca    14640

tggtgatttc tcacttgata accttatttt tgacgagggg aaattaatag gttgtattga    14700

tgttggacga gtcggaatcg cagaccgata ccaggatctt gccatcctat ggaactgcct    14760

cggtgagttt tctccttcat tacagaaacg gctttttcaa aaatatggta ttgataatcc    14820

tgatatgaat aaattgcagt ttcacttgat gctcgatgag tttttctaac ctaggtgaca    14880

gaagtcaaaa gcctccggtc ggaggctttt gactttctgc tagatctgtt tcaatgcggt    14940

gaagggccag gcagctgggg attatgtcca gacccggcca gcatgttggt tttatcgcat    15000

attcagcgtt gtcgcgttta cccaggtaaa atggaagcag tgtatcgtct gcgtgaatgt    15060

gcaaatcagg aacgtaaccg tggtacatag atgcagtccc ttgcgggtcg ttcccttcaa    15120

cgagtaggac gcggtgccct tgcaaggcta accattgcgc ctggtgtact gcagatgagg    15180

ttttataaac ccctcccttg tgtgacataa cggaaagtac aaccgggttt ttatcgtcag    15240

gtctttggtt tgggttacca aacacactcc gcatatggct aatttggtca attgtgtagc    15300

cagcgcgacg ttctactcgg cccctcatct caaaatcagg agccggtaga cgaccagctt    15360

tttccgcatc tctgatagcc tgcggtgtta cgccgatcag gtctgcaact tctgttatac    15420

cccagcggcg agtaatacga cgcgcttccg ggctgtcatc gccgaactgt gcgatggcaa    15480

tagcgcgcgt catttcctga ccgcgattga tacagtcttt cagcaaatta attaacgaca    15540

tcctgtttcc tctcaaacat gcccttatct ttgtgttttt catcatactt tacgttttta    15600

aagcaaagca acataaaaaa agcaaagtga cttagaaaac gcaaagttaa ggttcaaatc    15660

aattttttga tgcgctacag aagctattta gcttcatcta agcgcaacgg tattacttac    15720

gttggtatat ttaaaaccta acttaatgat tttaaatgat aataaatcat accaattgct    15780

atcaaaagtt aagcgaacat gctgattttc acgctgttta tacactttga ggcatctcta    15840

tctcttctgt ctctatattg aaacacaatc aaagaacatc aatccatgtg acatccccca    15900

ctatctaaga acaccataac agaacacaac ataggaatgc aacattaatg tatcaataat    15960

tcggaacata tgcactatat catatctcaa ttacggaaca tatcagcaca caattgccca    16020

ttatacgc                                                             16028


<210>  60
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  60

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  61
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  61

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  62
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  62

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  63
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  63

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  64
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  64

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  65
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  65

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  66
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  66

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  67
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  67

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  68
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  68

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  69
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  polynucleotide sequence for exemplary 2A sites

<400>  69

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  70
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  70

Gly Gly Gly 
1           


<210>  71
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  71

Asp Gly Gly Gly Ser 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  72

Thr Gly Glu Lys Pro 
1               5   


<210>  73
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  73

Gly Gly Arg Arg 
1               


<210>  74
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  74

Gly Gly Gly Gly Ser 
1               5   


<210>  75
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  75

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  76
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  76

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  77
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  77

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  78
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  78

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  79
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  79

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  80

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  81
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  81
ccagccttgc cttgaccaat agccttgaca aggcaaactt gaccaatagt cttagagtat       60

c                                                                       61


<210>  82
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  82
catgggttgg ccagccttgc cttgaccaat agccttgaca aggcaaactt gaccaatagt       60

c                                                                       61


<210>  83
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  83

Cys Thr Thr Gly Ala Cys Cys Ala Ala Thr Ala Gly Cys Cys Thr Thr 
1               5                   10                  15      


Gly Ala Cys Ala Ala Gly Gly Cys Ala Ala Ala Cys Thr Thr Gly Ala 
            20                  25                  30          


Cys Cys Ala Ala Thr Ala Gly Thr Cys 
        35                  40      


<210>  84
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  ddPCR assay

<400>  84
aaactacagg cctcactgga atcctctatg atgggagaag gaaactcctt gaccaatagc       60

cttgacaaaa aggaagcacc cttcagc                                           87


<210>  85
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  ddPCR assay

<400>  85
aaactacagg cctcactgga atcttctatg gtgggagaag aaaactcctt gaccaatagc       60

cttgacaaaa aggaagcacc cttcagc                                           87


<210>  86
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  86
ggccagcctt gccttgacca atagccttga caaggcaa                               38


<210>  87
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  87
ccttgaccaa tagccttgac aaggcaaact tgaccaatag                             40


<210>  88
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  88
gggttggcca gtcttgccaa tagccttgac aaggcaacct                             40


<210>  89
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  89
gggttggcca gtcttgcctt gaaatagcct tgacaaggca acct                        44


<210>  90
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  90
gggttggcca gtcttgcctt gaatagcctt gacaaggcaa cct                         43


<210>  91
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  91
gggttggcca gtcttgcctt gacaaggcaa cct                                    33


<210>  92
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  92
gggttggcca gtcttgcctt gacaatagcc ttgacaaggc aacct                       45


<210>  93
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  93
gggttggcca gtcttgcctt gatagccttg acaaggcaac ct                          42


