                         SEQUENCE LISTING

<110>  Case Western Reserve Univesity
       Susann, BRADY-KALNAY
 
<120>  METHODS AND AGENTS FOR THE DETECTION AND TREATMENT OF CANCER

<130>  CWR-026557WO ORD

<150>  62/489,231
<151>  2017-04-24

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1465
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro 
        275                 280                 285             


Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala 
    290                 295                 300                 


Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr 
305                 310                 315                 320 


Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr 
                325                 330                 335     


Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser 
            340                 345                 350         


Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro 
        355                 360                 365             


Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg 
    370                 375                 380                 


Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp 
385                 390                 395                 400 


Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr 
                405                 410                 415     


Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu 
            420                 425                 430         


Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn 
        435                 440                 445             


Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro 
    450                 455                 460                 


Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp 
465                 470                 475                 480 


Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu 
                485                 490                 495     


Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val 
            500                 505                 510         


Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro 
        515                 520                 525             


Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn 
    530                 535                 540                 


Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser 
545                 550                 555                 560 


Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr 
                565                 570                 575     


Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu 
            580                 585                 590         


Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu 
        595                 600                 605             


Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val 
    610                 615                 620                 


Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu 
625                 630                 635                 640 


Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn 
                645                 650                 655     


Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala 
            660                 665                 670         


Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp 
        675                 680                 685             


Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe Gln Ala 
    690                 695                 700                 


Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala 
705                 710                 715                 720 


Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln 
                725                 730                 735     


Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu 
            740                 745                 750         


Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys 
        755                 760                 765             


Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met 
    770                 775                 780                 


Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr 
785                 790                 795                 800 


Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly 
                805                 810                 815     


Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu 
            820                 825                 830         


Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Pro Phe Val Pro Thr 
        835                 840                 845             


Ala Ile Leu Val Pro Ile Asn Asp Glu Thr His Thr Met Ala Ser Asp 
    850                 855                 860                 


Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg Glu Pro Ala 
865                 870                 875                 880 


Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile Arg Val Ala 
                885                 890                 895     


Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu Gly Tyr Gly 
            900                 905                 910         


Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser Ala Pro Trp 
        915                 920                 925             


Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg Tyr Gly Asn 
    930                 935                 940                 


Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr Ile Glu Gly 
945                 950                 955                 960 


Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp Gly Tyr His 
                965                 970                 975     


Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Ile 
            980                 985                 990         


Tyr Asp Phe Trp Arg Met Val Trp  His Glu Asn Thr Ala  Ser Ile Ile 
        995                 1000                 1005             


Met Val  Thr Asn Leu Val Glu  Val Gly Arg Val Lys  Cys Cys Lys 
    1010                 1015                 1020             


Tyr Trp  Pro Asp Asp Thr Glu  Ile Tyr Lys Asp Ile  Lys Val Thr 
    1025                 1030                 1035             


Leu Ile  Glu Thr Glu Leu Leu  Ala Glu Tyr Val Ile  Arg Thr Phe 
    1040                 1045                 1050             


Ala Val  Glu Lys Arg Gly Val  His Glu Ile Arg Glu  Ile Arg Gln 
    1055                 1060                 1065             


Phe His  Phe Thr Gly Trp Pro  Asp His Gly Val Pro  Tyr His Ala 
    1070                 1075                 1080             


Thr Gly  Leu Leu Gly Phe Val  Arg Gln Val Lys Ser  Lys Ser Pro 
    1085                 1090                 1095             


Pro Ser  Ala Gly Pro Leu Val  Val His Cys Ser Ala  Gly Ala Gly 
    1100                 1105                 1110             


Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ile Met Leu  Asp Met Ala 
    1115                 1120                 1125             


Glu Arg  Glu Gly Val Val Asp  Ile Tyr Asn Cys Val  Arg Glu Leu 
    1130                 1135                 1140             


Arg Ser  Arg Arg Val Asn Met  Val Gln Thr Glu Glu  Gln Tyr Val 
    1145                 1150                 1155             


Phe Ile  His Asp Ala Ile Leu  Glu Ala Cys Leu Cys  Gly Asp Thr 
    1160                 1165                 1170             


Ser Val  Pro Ala Ser Gln Val  Arg Ser Leu Tyr Tyr  Asp Met Asn 
    1175                 1180                 1185             


Lys Leu  Asp Pro Gln Thr Asn  Ser Ser Gln Ile Lys  Glu Glu Phe 
    1190                 1195                 1200             


Arg Thr  Leu Asn Met Val Thr  Pro Thr Leu Arg Val  Glu Asp Cys 
    1205                 1210                 1215             


Ser Ile  Ala Leu Leu Pro Arg  Asn His Glu Lys Asn  Arg Cys Met 
    1220                 1225                 1230             


Asp Ile  Leu Pro Pro Asp Arg  Cys Leu Pro Phe Leu  Ile Thr Ile 
    1235                 1240                 1245             


Asp Gly  Glu Ser Ser Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser 
    1250                 1255                 1260             


Tyr Lys  Gln Pro Ser Ala Phe  Ile Val Thr Gln His  Pro Leu Pro 
    1265                 1270                 1275             


Asn Thr  Val Lys Asp Phe Trp  Arg Leu Val Leu Asp  Tyr His Cys 
    1280                 1285                 1290             


Thr Ser  Val Val Met Leu Asn  Asp Val Asp Pro Ala  Gln Leu Cys 
    1295                 1300                 1305             


Pro Gln  Tyr Trp Leu Glu Asn  Gly Val His Arg His  Gly Pro Ile 
    1310                 1315                 1320             


Gln Val  Glu Phe Val Ser Ala  Asp Leu Glu Glu Asp  Ile Ile Ser 
    1325                 1330                 1335             


Arg Ile  Phe Arg Ile Tyr Asn  Ala Ala Arg Pro Gln  Asp Gly Tyr 
    1340                 1345                 1350             


Arg Met  Val Gln Gln Phe Gln  Phe Leu Gly Trp Pro  Met Tyr Arg 
    1355                 1360                 1365             


Asp Thr  Pro Val Ser Lys Arg  Ser Phe Leu Lys Leu  Ile Arg Gln 
    1370                 1375                 1380             


Val Asp  Lys Trp Gln Glu Glu  Tyr Asn Gly Gly Glu  Gly Arg Thr 
    1385                 1390                 1395             


Val Val  His Cys Leu Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys 
    1400                 1405                 1410             


Ala Ile  Ser Ile Val Cys Glu  Met Leu Arg His Gln  Arg Thr Val 
    1415                 1420                 1425             


Asp Val  Phe His Ala Val Lys  Thr Leu Arg Asn Asn  Lys Pro Asn 
    1430                 1435                 1440             


Met Val  Asp Leu Leu Asp Gln  Tyr Lys Phe Cys Tyr  Glu Val Ala 
    1445                 1450                 1455             


Leu Glu  Tyr Leu Asn Ser Gly  
    1460                 1465 


<210>  2
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro 
        275                 280                 285             


Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala 
    290                 295                 300                 


Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr 
305                 310                 315                 320 


Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr 
                325                 330                 335     


Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser 
            340                 345                 350         


Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro 
        355                 360                 365             


Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg 
    370                 375                 380                 


Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp 
385                 390                 395                 400 


Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr 
                405                 410                 415     


Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu 
            420                 425                 430         


Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn 
        435                 440                 445             


Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro 
    450                 455                 460                 


Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr 
465                 470                 475         


<210>  3
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu 
        275                 280 


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro Tyr Ser Thr Cys 
1               5                   10                  15      


Gly Tyr Ser Gln 
            20  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Glu Gly Glu Gly Asp Asp Phe Asn Trp Glu Gln Val Asn Thr Leu Thr 
1               5                   10                  15      


Lys Pro Thr Ser Asp 
            20      


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Thr Pro His Phe Leu Arg Ile Gln Asn Val Glu Val Asn Ala Gly Gln 
1               5                   10                  15      


Phe Ala Thr 
            


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Gly Ile Asp Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser 
1               5                   10                  15      


Ser Arg 
        


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Cys Gly Glu Gly Asp Asp Phe Asn Trp Glu Gln Val Asn Thr Leu Thr 
1               5                   10                  15      


Lys Pro Thr Ser Asp 
            20      


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gly Thr Gln Asp Glu Thr Gly Asn Phe Asp Trp Pro Val Ser Glu Asp 
1               5                   10                  15      


Leu Asn Lys Thr 
            20  


