                         SEQUENCE LISTING

<110>  NantCell
 
<120>  Targeted Neoepitope Vectors And Methods Therefor

<130>  102538.0033PCT

<150>  US 62/489,102
<151>  2017-04-24

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-I nucleic acid for MHC-I presentation

<400>  1
atggataaaa tcacgcagta cgaaaagtca ttgtactatt gttctttcct ggaggccctc       60

gttagagatg tatgcatcgc tgcagctgcc tgtgtcgact gtcttgacag aaccaacacc      120

gcccaggtaa tggttggaaa atgtgctctg gcctaccagc tgtatgcagc cgccgcagtg      180

gtcaaagcat acctgcctgt caatgaatct ttcgccttca ctgccgattt gaggagcaat      240

actggcggcc aggcagcagc cgcaaacatc ctggctgtgt ccttcgcacc tctggtgcaa      300

ctcagtaaaa acgacaacgg aactcctgac tccgtgggag cagccgccgc acagagtaac      360

taccagcaca tcacgaattt tgagtggtgc atttccatac tggttgaact gacgcgcctg      420

gagggtgcag ctgccgctta ttacacagtg ttcgatcggg acaacaatcg ggtctctttt      480

gctaatgctg tggtgctggc cgctgccgct cacagcggac tggtcacttt ccaagccttt      540

attgatgtga tgtcaaggga aacaactgac acagacactg cagacgctgc cgcagccctg      600

gatctggccg ctttggaaga cgtctccgcc aactgtctca ctgagaccct ggaggacaag      660

aatgaaggtg tggccgctgc cgctgtcctg tcattcgtgg gccagacgag ggtgttgatg      720

atcaacgggg aagaagttga agaaacagaa ctgatgggtg ccgctgccgc agaggtgtcc      780

ggactcgagc agctggaatc tataattaac tttgaaaagt tgacggaatg gacttcctct      840

aacgtggccg ctgccgctat gacggagcaa caatggaact tcgcaggcat cgaggctgcc      900

gccagcgcca tccaaggaaa cgtaacttca atccacagcc ttctggatgc tgctgctgcc      960

gaacaaaagc tcatcagtga ggaggacttg taa                                   993


<210>  2
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-I nucleic acid for MHC-I presentation (Ubiquitin, cleavable)

<400>  2
atgcagattt ttgtgaagac actgaccgga aaaactatca ccctcgaggt ggagccttcc       60

gacactatcg aaaacgtcaa ggccaagatc caggacaagg aaggcattcc acccgatcag      120

cagcgcctta tttttgcagg taagcagctg gaagacggaa ggaccctgag cgactataat      180

atccagaaag aaagcacact ccacctcgtg ctcaggctcc gcgggggcag ggataaaatc      240

acgcagtacg aaaagtcatt gtactattgt tctttcctgg aggccctcgt tagagatgta      300

tgcatcgctg cagctgcctg tgtcgactgt cttgacagaa ccaacaccgc ccaggtaatg      360

gttggaaaat gtgctctggc ctaccagctg tatgcagccg ccgcagtggt caaagcatac      420

ctgcctgtca atgaatcttt cgccttcact gccgatttga ggagcaatac tggcggccag      480

gcagcagccg caaacatcct ggctgtgtcc ttcgcacctc tggtgcaact cagtaaaaac      540

gacaacggaa ctcctgactc cgtgggagca gccgccgcac agagtaacta ccagcacatc      600

acgaattttg agtggtgcat ttccatactg gttgaactga cgcgcctgga gggtgcagct      660

gccgcttatt acacagtgtt cgatcgggac aacaatcggg tctcttttgc taatgctgtg      720

gtgctggccg ctgccgctca cagcggactg gtcactttcc aagcctttat tgatgtgatg      780

tcaagggaaa caactgacac agacactgca gacgctgccg cagccctgga tctggccgct      840

ttggaagacg tctccgccaa ctgtctcact gagaccctgg aggacaagaa tgaaggtgtg      900

gccgctgccg ctgtcctgtc attcgtgggc cagacgaggg tgttgatgat caacggggaa      960

gaagttgaag aaacagaact gatgggtgcc gctgccgcag aggtgtccgg actcgagcag     1020

ctggaatcta taattaactt tgaaaagttg acggaatgga cttcctctaa cgtggccgct     1080

gccgctatga cggagcaaca atggaacttc gcaggcatcg aggctgccgc cagcgccatc     1140

caaggaaacg taacttcaat ccacagcctt ctggatgctg ctgctgccga acaaaagctc     1200

atcagtgagg aggacttgta a                                               1221


<210>  3
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-I nucleic acid for MHC-I presentation (Ubiquitin, 
       non-cleavable)

<400>  3
atgcagattt ttgtgaagac actgaccgga aaaactatca ccctcgaggt ggagccttcc       60

gacactatcg aaaacgtcaa ggccaagatc caggacaagg aaggcattcc acccgatcag      120

cagcgcctta tttttgcagg taagcagctg gaagacggaa ggaccctgag cgactataat      180

atccagaaag aaagcacact ccacctcgtg ctcaggctcc gcggggataa aatcacgcag      240

tacgaaaagt cattgtacta ttgttctttc ctggaggccc tcgttagaga tgtatgcatc      300

gctgcagctg cctgtgtcga ctgtcttgac agaaccaaca ccgcccaggt aatggttgga      360

aaatgtgctc tggcctacca gctgtatgca gccgccgcag tggtcaaagc atacctgcct      420

gtcaatgaat ctttcgcctt cactgccgat ttgaggagca atactggcgg ccaggcagca      480

gccgcaaaca tcctggctgt gtccttcgca cctctggtgc aactcagtaa aaacgacaac      540

ggaactcctg actccgtggg agcagccgcc gcacagagta actaccagca catcacgaat      600

tttgagtggt gcatttccat actggttgaa ctgacgcgcc tggagggtgc agctgccgct      660

tattacacag tgttcgatcg ggacaacaat cgggtctctt ttgctaatgc tgtggtgctg      720

gccgctgccg ctcacagcgg actggtcact ttccaagcct ttattgatgt gatgtcaagg      780

gaaacaactg acacagacac tgcagacgct gccgcagccc tggatctggc cgctttggaa      840

gacgtctccg ccaactgtct cactgagacc ctggaggaca agaatgaagg tgtggccgct      900

gccgctgtcc tgtcattcgt gggccagacg agggtgttga tgatcaacgg ggaagaagtt      960

gaagaaacag aactgatggg tgccgctgcc gcagaggtgt ccggactcga gcagctggaa     1020

tctataatta actttgaaaa gttgacggaa tggacttcct ctaacgtggc cgctgccgct     1080

atgacggagc aacaatggaa cttcgcaggc atcgaggctg ccgccagcgc catccaagga     1140

aacgtaactt caatccacag ccttctggat gctgctgctg ccgaacaaaa gctcatcagt     1200

gaggaggact tgtaa                                                      1215


<210>  4
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-I polypeptide for MHC-I presentation

<400>  4

Met Asp Lys Ile Thr Gln Tyr Glu Lys Ser Leu Tyr Tyr Cys Ser Phe 
1               5                   10                  15      


Leu Glu Ala Leu Val Arg Asp Val Cys Ile Ala Ala Ala Ala Cys Val 
            20                  25                  30          


Asp Cys Leu Asp Arg Thr Asn Thr Ala Gln Val Met Val Gly Lys Cys 
        35                  40                  45              


Ala Leu Ala Tyr Gln Leu Tyr Ala Ala Ala Ala Val Val Lys Ala Tyr 
    50                  55                  60                  


Leu Pro Val Asn Glu Ser Phe Ala Phe Thr Ala Asp Leu Arg Ser Asn 
65                  70                  75                  80  


Thr Gly Gly Gln Ala Ala Ala Ala Asn Ile Leu Ala Val Ser Phe Ala 
                85                  90                  95      


Pro Leu Val Gln Leu Ser Lys Asn Asp Asn Gly Thr Pro Asp Ser Val 
            100                 105                 110         


Gly Ala Ala Ala Ala Gln Ser Asn Tyr Gln His Ile Thr Asn Phe Glu 
        115                 120                 125             


Trp Cys Ile Ser Ile Leu Val Glu Leu Thr Arg Leu Glu Gly Ala Ala 
    130                 135                 140                 


Ala Ala Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn Arg Val Ser Phe 
145                 150                 155                 160 


Ala Asn Ala Val Val Leu Ala Ala Ala Ala His Ser Gly Leu Val Thr 
                165                 170                 175     


Phe Gln Ala Phe Ile Asp Val Met Ser Arg Glu Thr Thr Asp Thr Asp 
            180                 185                 190         


Thr Ala Asp Ala Ala Ala Ala Leu Asp Leu Ala Ala Leu Glu Asp Val 
        195                 200                 205             


Ser Ala Asn Cys Leu Thr Glu Thr Leu Glu Asp Lys Asn Glu Gly Val 
    210                 215                 220                 


Ala Ala Ala Ala Val Leu Ser Phe Val Gly Gln Thr Arg Val Leu Met 
225                 230                 235                 240 


Ile Asn Gly Glu Glu Val Glu Glu Thr Glu Leu Met Gly Ala Ala Ala 
                245                 250                 255     


Ala Glu Val Ser Gly Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu 
            260                 265                 270         


Lys Leu Thr Glu Trp Thr Ser Ser Asn Val Ala Ala Ala Ala Met Thr 
        275                 280                 285             


Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile 
    290                 295                 300                 


Gln Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Ala Ala Ala Ala 
305                 310                 315                 320 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                325                 330 


<210>  5
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-I polypeptide for MHC-I presentation (Ubiquitin, cleavable)

<400>  5

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Arg Asp Lys Ile 
65                  70                  75                  80  


Thr Gln Tyr Glu Lys Ser Leu Tyr Tyr Cys Ser Phe Leu Glu Ala Leu 
                85                  90                  95      


Val Arg Asp Val Cys Ile Ala Ala Ala Ala Cys Val Asp Cys Leu Asp 
            100                 105                 110         


Arg Thr Asn Thr Ala Gln Val Met Val Gly Lys Cys Ala Leu Ala Tyr 
        115                 120                 125             


Gln Leu Tyr Ala Ala Ala Ala Val Val Lys Ala Tyr Leu Pro Val Asn 
    130                 135                 140                 


Glu Ser Phe Ala Phe Thr Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln 
145                 150                 155                 160 


Ala Ala Ala Ala Asn Ile Leu Ala Val Ser Phe Ala Pro Leu Val Gln 
                165                 170                 175     


Leu Ser Lys Asn Asp Asn Gly Thr Pro Asp Ser Val Gly Ala Ala Ala 
            180                 185                 190         


Ala Gln Ser Asn Tyr Gln His Ile Thr Asn Phe Glu Trp Cys Ile Ser 
        195                 200                 205             


Ile Leu Val Glu Leu Thr Arg Leu Glu Gly Ala Ala Ala Ala Tyr Tyr 
    210                 215                 220                 


Thr Val Phe Asp Arg Asp Asn Asn Arg Val Ser Phe Ala Asn Ala Val 
225                 230                 235                 240 


Val Leu Ala Ala Ala Ala His Ser Gly Leu Val Thr Phe Gln Ala Phe 
                245                 250                 255     


Ile Asp Val Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Ala 
            260                 265                 270         


Ala Ala Ala Leu Asp Leu Ala Ala Leu Glu Asp Val Ser Ala Asn Cys 
        275                 280                 285             


Leu Thr Glu Thr Leu Glu Asp Lys Asn Glu Gly Val Ala Ala Ala Ala 
    290                 295                 300                 


Val Leu Ser Phe Val Gly Gln Thr Arg Val Leu Met Ile Asn Gly Glu 
305                 310                 315                 320 


Glu Val Glu Glu Thr Glu Leu Met Gly Ala Ala Ala Ala Glu Val Ser 
                325                 330                 335     


Gly Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu 
            340                 345                 350         


Trp Thr Ser Ser Asn Val Ala Ala Ala Ala Met Thr Glu Gln Gln Trp 
        355                 360                 365             


Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val 
    370                 375                 380                 


Thr Ser Ile His Ser Leu Leu Asp Ala Ala Ala Ala Glu Gln Lys Leu 
385                 390                 395                 400 


Ile Ser Glu Glu Asp Leu 
                405     


<210>  6
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-I polypeptide for MHC-I presentation (Ubiquitin, 
       non-cleavable)

<400>  6

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Asp Lys Ile Thr Gln 
65                  70                  75                  80  


Tyr Glu Lys Ser Leu Tyr Tyr Cys Ser Phe Leu Glu Ala Leu Val Arg 
                85                  90                  95      


Asp Val Cys Ile Ala Ala Ala Ala Cys Val Asp Cys Leu Asp Arg Thr 
            100                 105                 110         


Asn Thr Ala Gln Val Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu 
        115                 120                 125             


Tyr Ala Ala Ala Ala Val Val Lys Ala Tyr Leu Pro Val Asn Glu Ser 
    130                 135                 140                 


Phe Ala Phe Thr Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln Ala Ala 
145                 150                 155                 160 


Ala Ala Asn Ile Leu Ala Val Ser Phe Ala Pro Leu Val Gln Leu Ser 
                165                 170                 175     


Lys Asn Asp Asn Gly Thr Pro Asp Ser Val Gly Ala Ala Ala Ala Gln 
            180                 185                 190         


Ser Asn Tyr Gln His Ile Thr Asn Phe Glu Trp Cys Ile Ser Ile Leu 
        195                 200                 205             


Val Glu Leu Thr Arg Leu Glu Gly Ala Ala Ala Ala Tyr Tyr Thr Val 
    210                 215                 220                 


Phe Asp Arg Asp Asn Asn Arg Val Ser Phe Ala Asn Ala Val Val Leu 
225                 230                 235                 240 


Ala Ala Ala Ala His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile Asp 
                245                 250                 255     


Val Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Ala Ala Ala 
            260                 265                 270         


Ala Leu Asp Leu Ala Ala Leu Glu Asp Val Ser Ala Asn Cys Leu Thr 
        275                 280                 285             


Glu Thr Leu Glu Asp Lys Asn Glu Gly Val Ala Ala Ala Ala Val Leu 
    290                 295                 300                 


Ser Phe Val Gly Gln Thr Arg Val Leu Met Ile Asn Gly Glu Glu Val 
305                 310                 315                 320 


Glu Glu Thr Glu Leu Met Gly Ala Ala Ala Ala Glu Val Ser Gly Leu 
                325                 330                 335     


Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr 
            340                 345                 350         


Ser Ser Asn Val Ala Ala Ala Ala Met Thr Glu Gln Gln Trp Asn Phe 
        355                 360                 365             


Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser 
    370                 375                 380                 


Ile His Ser Leu Leu Asp Ala Ala Ala Ala Glu Gln Lys Leu Ile Ser 
385                 390                 395                 400 


Glu Glu Asp Leu 
                


<210>  7
<211>  1218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-I nucleic acid for MHC-II presentation (lysosomal target)

<400>  7
atgctgctgc tgccattcca gctcttggcc gtgctgttcc ccggggggaa ttctgaggat       60

aagatcaccc agtatgaaaa atccttgtat tattgtagct ttctggaagc cctggtgcga      120

gatgtgtgta taggcccagg gccggggtgt gttgattgcc tcgacaggac aaataccgcc      180

caggtaatgg ttggcaaatg cgcactcgca tatcaactct acggaccagg acccggcgtg      240

gtaaaggctt atctgccagt taacgagagc tttgccttca ccgcagacct gcgctccaat      300

actggtggtc aagggcccgg accaggtaat atcctcgccg tgagcttcgc ccctctggtc      360

cagctgagta aaaatgacaa tggtactcct gatagtgtag gcggacccgg tccgggtcag      420

tccaattacc agcacattac caatttcgaa tggtgcatca gtatactggt tgaattgacc      480

agactcgagg ggggcccagg cccaggctac tacactgttt tcgatcgcga caataatcgg      540

gttagcttcg ctaatgcagt agtgctgggc cccgggccag ggcactccgg tctggtgacg      600

ttccaggcct tcatcgatgt aatgagccgc gagactacgg acaccgacac cgctgatggc      660

cccgggcctg gtctggatct tgcagccctg gaggatgtgt ccgctaactg tttgactgag      720

acactggagg acaagaacga gggcgtcgga ccagggcctg gtgtcctttc tttcgtcggt      780

cagacaaggg tgttgatgat caatggagaa gaggtggaag agaccgaatt gatgggaggc      840

ccagggcccg gcgaggttag cggcctggaa cagctggaga gtattatcaa ttttgaaaag      900

ctgaccgagt ggacaagctc caatgtaggc ggacctggac ccgggatgac agagcagcag      960

tggaattttg ccggtattga agctgcagcc agtgctatcc aaggcaacgt aacgagtatt     1020

cacagcctgc tcgacgacta caaagacgac gacgacaagg gcagtgacta taaggaccat     1080

gatggtgact ataaggacca cgacatcatg ctcatcccaa tcgctgtcgg aggtgctctg     1140

gccggtctcg tattgatcgt tctgatcgct tatttgatcg ggaggaagag gagtcacgca     1200

ggctaccaga ctatctag                                                   1218


<210>  8
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-I nucleic acid for MHC-II presentation (recycling endosome 
       target)

<400>  8
atgctgctgc tgccattcca gctcttggcc gtgctgttcc ccggggggaa ttctgaggat       60

aagatcaccc agtatgaaaa atccttgtat tattgtagct ttctggaagc cctggtgcga      120

gatgtgtgta taggcccagg gccggggtgt gttgattgcc tcgacaggac aaataccgcc      180

caggtaatgg ttggcaaatg cgcactcgca tatcaactct acggaccagg acccggcgtg      240

gtaaaggctt atctgccagt taacgagagc tttgccttca ccgcagacct gcgctccaat      300

actggtggtc aagggcccgg accaggtaat atcctcgccg tgagcttcgc ccctctggtc      360

cagctgagta aaaatgacaa tggtactcct gatagtgtag gcggacccgg tccgggtcag      420

tccaattacc agcacattac caatttcgaa tggtgcatca gtatactggt tgaattgacc      480

agactcgagg ggggcccagg cccaggctac tacactgttt tcgatcgcga caataatcgg      540

gttagcttcg ctaatgcagt agtgctgggc cccgggccag ggcactccgg tctggtgacg      600

ttccaggcct tcatcgatgt aatgagccgc gagactacgg acaccgacac cgctgatggc      660

cccgggcctg gtctggatct tgcagccctg gaggatgtgt ccgctaactg tttgactgag      720

acactggagg acaagaacga gggcgtcgga ccagggcctg gtgtcctttc tttcgtcggt      780

cagacaaggg tgttgatgat caatggagaa gaggtggaag agaccgaatt gatgggaggc      840

ccagggcccg gcgaggttag cggcctggaa cagctggaga gtattatcaa ttttgaaaag      900

ctgaccgagt ggacaagctc caatgtaggc ggacctggac ccgggatgac agagcagcag      960

tggaattttg ccggtattga agctgcagcc agtgctatcc aaggcaacgt aacgagtatt     1020

cacagcctgc tcgacgacta caaagacgac gacgacaagg gcagtgacta taaggaccat     1080

gatggtgact ataaggacca cgacatcatg ctcatcccaa tcgctgtcgg aggtgctctg     1140

gccggtctcg tattgatcgt tctgatcgct tatttgatcg ggaggaaacg ctgtttctgt     1200

taa                                                                   1203


<210>  9
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-I nucleic acid for MHC-II presentation (sorting endosome 
       target)

<400>  9
atgctgctgc tgccattcca gctcttggcc gtgctgttcc ccggggggaa ttctgaggat       60

aagatcaccc agtatgaaaa atccttgtat tattgtagct ttctggaagc cctggtgcga      120

gatgtgtgta taggcccagg gccggggtgt gttgattgcc tcgacaggac aaataccgcc      180

caggtaatgg ttggcaaatg cgcactcgca tatcaactct acggaccagg acccggcgtg      240

gtaaaggctt atctgccagt taacgagagc tttgccttca ccgcagacct gcgctccaat      300

actggtggtc aagggcccgg accaggtaat atcctcgccg tgagcttcgc ccctctggtc      360

cagctgagta aaaatgacaa tggtactcct gatagtgtag gcggacccgg tccgggtcag      420

tccaattacc agcacattac caatttcgaa tggtgcatca gtatactggt tgaattgacc      480

agactcgagg ggggcccagg cccaggctac tacactgttt tcgatcgcga caataatcgg      540

gttagcttcg ctaatgcagt agtgctgggc cccgggccag ggcactccgg tctggtgacg      600

ttccaggcct tcatcgatgt aatgagccgc gagactacgg acaccgacac cgctgatggc      660

cccgggcctg gtctggatct tgcagccctg gaggatgtgt ccgctaactg tttgactgag      720

acactggagg acaagaacga gggcgtcgga ccagggcctg gtgtcctttc tttcgtcggt      780

cagacaaggg tgttgatgat caatggagaa gaggtggaag agaccgaatt gatgggaggc      840

ccagggcccg gcgaggttag cggcctggaa cagctggaga gtattatcaa ttttgaaaag      900

ctgaccgagt ggacaagctc caatgtaggc ggacctggac ccgggatgac agagcagcag      960

tggaattttg ccggtattga agctgcagcc agtgctatcc aaggcaacgt aacgagtatt     1020

cacagcctgc tcgacgacta caaagacgac gacgacaagg gcagtgacta taaggaccat     1080

gatggtgact ataaggacca cgacatcatg ctcatcccaa tcgctgtcgg aggtgctctg     1140

gccggtctcg tattgatcgt tctgatcgct tatttgatcg ggaagaagca ctgctcatat     1200

caggacatcc tgtga                                                      1215


<210>  10
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-I polypeptide for MHC-II presentation (lysosomal target)

<400>  10

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Asp Lys Ile Thr Gln Tyr Glu Lys Ser Leu Tyr Tyr Cys 
            20                  25                  30          


Ser Phe Leu Glu Ala Leu Val Arg Asp Val Cys Ile Gly Pro Gly Pro 
        35                  40                  45              


Gly Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala Gln Val Met Val 
    50                  55                  60                  


Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Gly Pro Gly Pro Gly Val 
65                  70                  75                  80  


Val Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr Ala Asp 
                85                  90                  95      


Leu Arg Ser Asn Thr Gly Gly Gln Gly Pro Gly Pro Gly Asn Ile Leu 
            100                 105                 110         


Ala Val Ser Phe Ala Pro Leu Val Gln Leu Ser Lys Asn Asp Asn Gly 
        115                 120                 125             


Thr Pro Asp Ser Val Gly Gly Pro Gly Pro Gly Gln Ser Asn Tyr Gln 
    130                 135                 140                 


His Ile Thr Asn Phe Glu Trp Cys Ile Ser Ile Leu Val Glu Leu Thr 
145                 150                 155                 160 


Arg Leu Glu Gly Gly Pro Gly Pro Gly Tyr Tyr Thr Val Phe Asp Arg 
                165                 170                 175     


Asp Asn Asn Arg Val Ser Phe Ala Asn Ala Val Val Leu Gly Pro Gly 
            180                 185                 190         


Pro Gly His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile Asp Val Met 
        195                 200                 205             


Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gly Pro Gly Pro Gly 
    210                 215                 220                 


Leu Asp Leu Ala Ala Leu Glu Asp Val Ser Ala Asn Cys Leu Thr Glu 
225                 230                 235                 240 


Thr Leu Glu Asp Lys Asn Glu Gly Val Gly Pro Gly Pro Gly Val Leu 
                245                 250                 255     


Ser Phe Val Gly Gln Thr Arg Val Leu Met Ile Asn Gly Glu Glu Val 
            260                 265                 270         


Glu Glu Thr Glu Leu Met Gly Gly Pro Gly Pro Gly Glu Val Ser Gly 
        275                 280                 285             


Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp 
    290                 295                 300                 


Thr Ser Ser Asn Val Gly Gly Pro Gly Pro Gly Met Thr Glu Gln Gln 
305                 310                 315                 320 


Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn 
                325                 330                 335     


Val Thr Ser Ile His Ser Leu Leu Asp Asp Tyr Lys Asp Asp Asp Asp 
            340                 345                 350         


Lys Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        355                 360                 365             


Ile Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val 
    370                 375                 380                 


Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser His Ala 
385                 390                 395                 400 


Gly Tyr Gln Thr Ile 
                405 


<210>  11
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-I polypeptide for MHC-II presentation (recycling endosome 
       target)

<400>  11

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Asp Lys Ile Thr Gln Tyr Glu Lys Ser Leu Tyr Tyr Cys 
            20                  25                  30          


Ser Phe Leu Glu Ala Leu Val Arg Asp Val Cys Ile Gly Pro Gly Pro 
        35                  40                  45              


Gly Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala Gln Val Met Val 
    50                  55                  60                  


Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Gly Pro Gly Pro Gly Val 
65                  70                  75                  80  


Val Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr Ala Asp 
                85                  90                  95      


Leu Arg Ser Asn Thr Gly Gly Gln Gly Pro Gly Pro Gly Asn Ile Leu 
            100                 105                 110         


Ala Val Ser Phe Ala Pro Leu Val Gln Leu Ser Lys Asn Asp Asn Gly 
        115                 120                 125             


Thr Pro Asp Ser Val Gly Gly Pro Gly Pro Gly Gln Ser Asn Tyr Gln 
    130                 135                 140                 


His Ile Thr Asn Phe Glu Trp Cys Ile Ser Ile Leu Val Glu Leu Thr 
145                 150                 155                 160 


Arg Leu Glu Gly Gly Pro Gly Pro Gly Tyr Tyr Thr Val Phe Asp Arg 
                165                 170                 175     


Asp Asn Asn Arg Val Ser Phe Ala Asn Ala Val Val Leu Gly Pro Gly 
            180                 185                 190         


Pro Gly His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile Asp Val Met 
        195                 200                 205             


Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gly Pro Gly Pro Gly 
    210                 215                 220                 


Leu Asp Leu Ala Ala Leu Glu Asp Val Ser Ala Asn Cys Leu Thr Glu 
225                 230                 235                 240 


Thr Leu Glu Asp Lys Asn Glu Gly Val Gly Pro Gly Pro Gly Val Leu 
                245                 250                 255     


Ser Phe Val Gly Gln Thr Arg Val Leu Met Ile Asn Gly Glu Glu Val 
            260                 265                 270         


Glu Glu Thr Glu Leu Met Gly Gly Pro Gly Pro Gly Glu Val Ser Gly 
        275                 280                 285             


Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp 
    290                 295                 300                 


Thr Ser Ser Asn Val Gly Gly Pro Gly Pro Gly Met Thr Glu Gln Gln 
305                 310                 315                 320 


Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn 
                325                 330                 335     


Val Thr Ser Ile His Ser Leu Leu Asp Asp Tyr Lys Asp Asp Asp Asp 
            340                 345                 350         


Lys Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        355                 360                 365             


Ile Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val 
    370                 375                 380                 


Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Cys Phe Cys 
385                 390                 395                 400 


<210>  12
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-I polypeptide for MHC-II presentation (sorting endosome 
       target)

<400>  12

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Asp Lys Ile Thr Gln Tyr Glu Lys Ser Leu Tyr Tyr Cys 
            20                  25                  30          


Ser Phe Leu Glu Ala Leu Val Arg Asp Val Cys Ile Gly Pro Gly Pro 
        35                  40                  45              


Gly Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala Gln Val Met Val 
    50                  55                  60                  


Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Gly Pro Gly Pro Gly Val 
65                  70                  75                  80  


Val Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Ala Phe Thr Ala Asp 
                85                  90                  95      


Leu Arg Ser Asn Thr Gly Gly Gln Gly Pro Gly Pro Gly Asn Ile Leu 
            100                 105                 110         


Ala Val Ser Phe Ala Pro Leu Val Gln Leu Ser Lys Asn Asp Asn Gly 
        115                 120                 125             


Thr Pro Asp Ser Val Gly Gly Pro Gly Pro Gly Gln Ser Asn Tyr Gln 
    130                 135                 140                 


His Ile Thr Asn Phe Glu Trp Cys Ile Ser Ile Leu Val Glu Leu Thr 
145                 150                 155                 160 


Arg Leu Glu Gly Gly Pro Gly Pro Gly Tyr Tyr Thr Val Phe Asp Arg 
                165                 170                 175     


Asp Asn Asn Arg Val Ser Phe Ala Asn Ala Val Val Leu Gly Pro Gly 
            180                 185                 190         


Pro Gly His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile Asp Val Met 
        195                 200                 205             


Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gly Pro Gly Pro Gly 
    210                 215                 220                 


Leu Asp Leu Ala Ala Leu Glu Asp Val Ser Ala Asn Cys Leu Thr Glu 
225                 230                 235                 240 


Thr Leu Glu Asp Lys Asn Glu Gly Val Gly Pro Gly Pro Gly Val Leu 
                245                 250                 255     


Ser Phe Val Gly Gln Thr Arg Val Leu Met Ile Asn Gly Glu Glu Val 
            260                 265                 270         


Glu Glu Thr Glu Leu Met Gly Gly Pro Gly Pro Gly Glu Val Ser Gly 
        275                 280                 285             


Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Trp 
    290                 295                 300                 


Thr Ser Ser Asn Val Gly Gly Pro Gly Pro Gly Met Thr Glu Gln Gln 
305                 310                 315                 320 


Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn 
                325                 330                 335     


Val Thr Ser Ile His Ser Leu Leu Asp Asp Tyr Lys Asp Asp Asp Asp 
            340                 345                 350         


Lys Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
        355                 360                 365             


Ile Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val 
    370                 375                 380                 


Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Lys Lys His Cys Ser Tyr 
385                 390                 395                 400 


Gln Asp Ile Leu 
                


<210>  13
<211>  2712
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-II nucleic acid for MHC-II presentation (lysosomal target)

<400>  13
atgctgctgc tgcccttcca gttgctggct gtcctctttc ccggcggcaa ctccgaggca       60

ctgcaggcct accacctgga tcctcaatgc tggggcgtga acgtgcagcc ctactccggg      120

agccctgcca atgtcgcagt ttatacagct ttggtagagc ctcatggcag aatcatgggt      180

ctcgatcttc cagacggcgg gcatctcacg ggccctggtc cgggtgatac cgatgaagct      240

gaggatccag agaaaatgct tgccaacttt gagtccggaa agcataagta tcgacagaca      300

gccatgttta ccgccaccat gccaccagcc gtcgagagac tggctagatc ctacctgagg      360

agacctgctg tggtgtacgg cccaggcccg ggcaggcggt atctgttgca gaacacagct      420

ctcgaagtct tcatggcaaa tcgcacttct gttatgttca actttcctga acaagccacg      480

gtgaagaaag tggtatattc ccttcccagg gttggggtcg gcacaagcta tgggctcccc      540

caagcagggc caggaccagg gaagattgag cccgatatga tgtcaatgga acatagcttc      600

gaaacggcat cccatgacgg agaggctggc ccctccccag aagtgttgca gggccctgga      660

cctggcaagg ttctgatggc atccacttcc tacttgccct cccaggtcac tgagatgttt      720

aaccagggaa gggcatttgc agcagtcaga ttgccttttt gtggacacaa aaacatctgt      780

agcctgacaa caatccagaa gattccacga ctgctcgtag gacctggacc tggcatgccc      840

gcagccgagt tggcactcag cgccttcctc gtcctcgtct ttttgtgggt gcattctttg      900

cgccgccttc tcgaatgctt ctatgtatct gtattctcta acgccgccat ccatgttgta      960

caatactgtt tcggcctcgt gtactacggt cctggccccg gactcctcga gctcctgcac     1020

tgcccacttg gtcactgtca tctgtgttcc gagccgatgt tcacgtttgt gtaccccaca     1080

attttcccac tcagagagac tcctatggct gggcttcacc agcggcgaac gtccatcggc     1140

ttcgtggcct attgtggccc aggcccaggc gcccattttc gccttgtgtc aaaggaaaag     1200

atgccgtggg acagcatcaa actgaccttc gaggcaaccg gacctaggca catgagcttc     1260

tatgtgcgca cccacaaggg ttctaccctc agccagtggt cactgggtaa tggaattcca     1320

gtgggccctg gaccgggagg taggacacag caaatgctca ttcccgcttg gcaacaggtt     1380

acacctatgg ctccagccgc cgccacattg acattcgagg gcatggccgg atctcagagg     1440

ctgggcgact ggggaaagat gattccccac agcaaccatt acaactccgt tgggccaggc     1500

cctggtgaac ttcagctcgt ccagttggag ggcgggggcg gcagcgggac atatagagtc     1560

gggaacgccc aaccatcact cgccgattgt ctggacgccg gggatcttgc ccagcgcctc     1620

agagagcatg gcgccgaagt gcccacagaa cctaaagagg gaccaggacc cggcgagctt     1680

gaaaagttcc gcaagtctga ggagggtaag caacgggccg ccgcccccag tgccgccagc     1740

tcaccagcag acgtccagag cctgaagaag gccatgtcct ctctgcagaa tgacagggac     1800

cggctgctca aggaactgaa gaatctgggc cccggccctg ggggcaaaca cgaccgggat     1860

ctgctgattg ggaccgctaa gcacggtctg aatcgaactg attactacat catgaatgga     1920

cctcagctct catttctcga cgcatacaga aactacgccc agcataaacg aactgacaca     1980

caggctcctg gcagtggacc cggccctgga attctcgagg tggacaaaag cggccctatt     2040

actctcttgg tgcagggaca catggaggga gaggtctggg ggctgtctac tcatccatac     2100

ctgcccatat gcgccaccgt tagtgatgac aaaactctca gaatttggga cttgtccccg     2160

tccggcccag gtcctggtat gctcaccgct cggcttttgc tcccaaggct gctctgtctt     2220

cagggcagga ccactagtta ttcaacagcc gcagtactgc ccaatccaat cccaaacccc     2280

gagatttgtt ataataagtt gtttatcaat aacgagtggc acgacgccgt cggcccgggc     2340

cctggggaag ttagtggtct ggaacagctg gaatctatca ttaatttcga gaaactgaca     2400

gaatggactt ccagcaacgt cgggggacca ggtcctggaa tgacagagca gcagtggaat     2460

tttgccggaa ttgaggccgc tgcatctgcc atccaaggaa atgtgacatc cattcactcc     2520

ctcctcgatg attacaagga cgacgacgac aagggaagtg actacaaaga ccacgacggg     2580

gactacaagg accacgacat tatgctgatc cccatcgccg tgggcggggc cctggccggc     2640

ctcgtgctga tcgtccttat cgcctacctc atcggcagga agaggagtca cgcaggctac     2700

cagactatct ag                                                         2712


<210>  14
<211>  2697
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-II nucleic acid for MHC-II presentation (recycling endosome 
       target)

<400>  14
atgctgctgc tgcccttcca gttgctggct gtcctctttc ccggcggcaa ctccgaggca       60

ctgcaggcct accacctgga tcctcaatgc tggggcgtga acgtgcagcc ctactccggg      120

agccctgcca atgtcgcagt ttatacagct ttggtagagc ctcatggcag aatcatgggt      180

ctcgatcttc cagacggcgg gcatctcacg ggccctggtc cgggtgatac cgatgaagct      240

gaggatccag agaaaatgct tgccaacttt gagtccggaa agcataagta tcgacagaca      300

gccatgttta ccgccaccat gccaccagcc gtcgagagac tggctagatc ctacctgagg      360

agacctgctg tggtgtacgg cccaggcccg ggcaggcggt atctgttgca gaacacagct      420

ctcgaagtct tcatggcaaa tcgcacttct gttatgttca actttcctga acaagccacg      480

gtgaagaaag tggtatattc ccttcccagg gttggggtcg gcacaagcta tgggctcccc      540

caagcagggc caggaccagg gaagattgag cccgatatga tgtcaatgga acatagcttc      600

gaaacggcat cccatgacgg agaggctggc ccctccccag aagtgttgca gggccctgga      660

cctggcaagg ttctgatggc atccacttcc tacttgccct cccaggtcac tgagatgttt      720

aaccagggaa gggcatttgc agcagtcaga ttgccttttt gtggacacaa aaacatctgt      780

agcctgacaa caatccagaa gattccacga ctgctcgtag gacctggacc tggcatgccc      840

gcagccgagt tggcactcag cgccttcctc gtcctcgtct ttttgtgggt gcattctttg      900

cgccgccttc tcgaatgctt ctatgtatct gtattctcta acgccgccat ccatgttgta      960

caatactgtt tcggcctcgt gtactacggt cctggccccg gactcctcga gctcctgcac     1020

tgcccacttg gtcactgtca tctgtgttcc gagccgatgt tcacgtttgt gtaccccaca     1080

attttcccac tcagagagac tcctatggct gggcttcacc agcggcgaac gtccatcggc     1140

ttcgtggcct attgtggccc aggcccaggc gcccattttc gccttgtgtc aaaggaaaag     1200

atgccgtggg acagcatcaa actgaccttc gaggcaaccg gacctaggca catgagcttc     1260

tatgtgcgca cccacaaggg ttctaccctc agccagtggt cactgggtaa tggaattcca     1320

gtgggccctg gaccgggagg taggacacag caaatgctca ttcccgcttg gcaacaggtt     1380

acacctatgg ctccagccgc cgccacattg acattcgagg gcatggccgg atctcagagg     1440

ctgggcgact ggggaaagat gattccccac agcaaccatt acaactccgt tgggccaggc     1500

cctggtgaac ttcagctcgt ccagttggag ggcgggggcg gcagcgggac atatagagtc     1560

gggaacgccc aaccatcact cgccgattgt ctggacgccg gggatcttgc ccagcgcctc     1620

agagagcatg gcgccgaagt gcccacagaa cctaaagagg gaccaggacc cggcgagctt     1680

gaaaagttcc gcaagtctga ggagggtaag caacgggccg ccgcccccag tgccgccagc     1740

tcaccagcag acgtccagag cctgaagaag gccatgtcct ctctgcagaa tgacagggac     1800

cggctgctca aggaactgaa gaatctgggc cccggccctg ggggcaaaca cgaccgggat     1860

ctgctgattg ggaccgctaa gcacggtctg aatcgaactg attactacat catgaatgga     1920

cctcagctct catttctcga cgcatacaga aactacgccc agcataaacg aactgacaca     1980

caggctcctg gcagtggacc cggccctgga attctcgagg tggacaaaag cggccctatt     2040

actctcttgg tgcagggaca catggaggga gaggtctggg ggctgtctac tcatccatac     2100

ctgcccatat gcgccaccgt tagtgatgac aaaactctca gaatttggga cttgtccccg     2160

tccggcccag gtcctggtat gctcaccgct cggcttttgc tcccaaggct gctctgtctt     2220

cagggcagga ccactagtta ttcaacagcc gcagtactgc ccaatccaat cccaaacccc     2280

gagatttgtt ataataagtt gtttatcaat aacgagtggc acgacgccgt cggcccgggc     2340

cctggggaag ttagtggtct ggaacagctg gaatctatca ttaatttcga gaaactgaca     2400

gaatggactt ccagcaacgt cgggggacca ggtcctggaa tgacagagca gcagtggaat     2460

tttgccggaa ttgaggccgc tgcatctgcc atccaaggaa atgtgacatc cattcactcc     2520

ctcctcgatg attacaagga cgacgacgac aagggaagtg actacaaaga ccacgacggg     2580

gactacaagg accacgacat tatgctgatc cccatcgccg tgggcggggc cctggccggc     2640

ctcgtgctga tcgtccttat cgcctacctc atcggcagga aacgctgttt ctgttaa        2697


<210>  15
<211>  2709
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC-II nucleic acid for MHC-II presentation (sorting endosome 
       target)

<400>  15
atgctgctgc tgcccttcca gttgctggct gtcctctttc ccggcggcaa ctccgaggca       60

ctgcaggcct accacctgga tcctcaatgc tggggcgtga acgtgcagcc ctactccggg      120

agccctgcca atgtcgcagt ttatacagct ttggtagagc ctcatggcag aatcatgggt      180

ctcgatcttc cagacggcgg gcatctcacg ggccctggtc cgggtgatac cgatgaagct      240

gaggatccag agaaaatgct tgccaacttt gagtccggaa agcataagta tcgacagaca      300

gccatgttta ccgccaccat gccaccagcc gtcgagagac tggctagatc ctacctgagg      360

agacctgctg tggtgtacgg cccaggcccg ggcaggcggt atctgttgca gaacacagct      420

ctcgaagtct tcatggcaaa tcgcacttct gttatgttca actttcctga acaagccacg      480

gtgaagaaag tggtatattc ccttcccagg gttggggtcg gcacaagcta tgggctcccc      540

caagcagggc caggaccagg gaagattgag cccgatatga tgtcaatgga acatagcttc      600

gaaacggcat cccatgacgg agaggctggc ccctccccag aagtgttgca gggccctgga      660

cctggcaagg ttctgatggc atccacttcc tacttgccct cccaggtcac tgagatgttt      720

aaccagggaa gggcatttgc agcagtcaga ttgccttttt gtggacacaa aaacatctgt      780

agcctgacaa caatccagaa gattccacga ctgctcgtag gacctggacc tggcatgccc      840

gcagccgagt tggcactcag cgccttcctc gtcctcgtct ttttgtgggt gcattctttg      900

cgccgccttc tcgaatgctt ctatgtatct gtattctcta acgccgccat ccatgttgta      960

caatactgtt tcggcctcgt gtactacggt cctggccccg gactcctcga gctcctgcac     1020

tgcccacttg gtcactgtca tctgtgttcc gagccgatgt tcacgtttgt gtaccccaca     1080

attttcccac tcagagagac tcctatggct gggcttcacc agcggcgaac gtccatcggc     1140

ttcgtggcct attgtggccc aggcccaggc gcccattttc gccttgtgtc aaaggaaaag     1200

atgccgtggg acagcatcaa actgaccttc gaggcaaccg gacctaggca catgagcttc     1260

tatgtgcgca cccacaaggg ttctaccctc agccagtggt cactgggtaa tggaattcca     1320

gtgggccctg gaccgggagg taggacacag caaatgctca ttcccgcttg gcaacaggtt     1380

acacctatgg ctccagccgc cgccacattg acattcgagg gcatggccgg atctcagagg     1440

ctgggcgact ggggaaagat gattccccac agcaaccatt acaactccgt tgggccaggc     1500

cctggtgaac ttcagctcgt ccagttggag ggcgggggcg gcagcgggac atatagagtc     1560

gggaacgccc aaccatcact cgccgattgt ctggacgccg gggatcttgc ccagcgcctc     1620

agagagcatg gcgccgaagt gcccacagaa cctaaagagg gaccaggacc cggcgagctt     1680

gaaaagttcc gcaagtctga ggagggtaag caacgggccg ccgcccccag tgccgccagc     1740

tcaccagcag acgtccagag cctgaagaag gccatgtcct ctctgcagaa tgacagggac     1800

cggctgctca aggaactgaa gaatctgggc cccggccctg ggggcaaaca cgaccgggat     1860

ctgctgattg ggaccgctaa gcacggtctg aatcgaactg attactacat catgaatgga     1920

cctcagctct catttctcga cgcatacaga aactacgccc agcataaacg aactgacaca     1980

caggctcctg gcagtggacc cggccctgga attctcgagg tggacaaaag cggccctatt     2040

actctcttgg tgcagggaca catggaggga gaggtctggg ggctgtctac tcatccatac     2100

ctgcccatat gcgccaccgt tagtgatgac aaaactctca gaatttggga cttgtccccg     2160

tccggcccag gtcctggtat gctcaccgct cggcttttgc tcccaaggct gctctgtctt     2220

cagggcagga ccactagtta ttcaacagcc gcagtactgc ccaatccaat cccaaacccc     2280

gagatttgtt ataataagtt gtttatcaat aacgagtggc acgacgccgt cggcccgggc     2340

cctggggaag ttagtggtct ggaacagctg gaatctatca ttaatttcga gaaactgaca     2400

gaatggactt ccagcaacgt cgggggacca ggtcctggaa tgacagagca gcagtggaat     2460

tttgccggaa ttgaggccgc tgcatctgcc atccaaggaa atgtgacatc cattcactcc     2520

ctcctcgatg attacaagga cgacgacgac aagggaagtg actacaaaga ccacgacggg     2580

gactacaagg accacgacat tatgctgatc cccatcgccg tgggcggggc cctggccggc     2640

ctcgtgctga tcgtccttat cgcctacctc atcggcaaga agcactgctc atatcaggac     2700

atcctgtga                                                             2709


<210>  16
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-II polypeptide for MHC-II presentation (lysosomal target)

<400>  16

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Ala Leu Gln Ala Tyr His Leu Asp Pro Gln Cys Trp Gly 
            20                  25                  30          


Val Asn Val Gln Pro Tyr Ser Gly Ser Pro Ala Asn Val Ala Val Tyr 
        35                  40                  45              


Thr Ala Leu Val Glu Pro His Gly Arg Ile Met Gly Leu Asp Leu Pro 
    50                  55                  60                  


Asp Gly Gly His Leu Thr Gly Pro Gly Pro Gly Asp Thr Asp Glu Ala 
65                  70                  75                  80  


Glu Asp Pro Glu Lys Met Leu Ala Asn Phe Glu Ser Gly Lys His Lys 
                85                  90                  95      


Tyr Arg Gln Thr Ala Met Phe Thr Ala Thr Met Pro Pro Ala Val Glu 
            100                 105                 110         


Arg Leu Ala Arg Ser Tyr Leu Arg Arg Pro Ala Val Val Tyr Gly Pro 
        115                 120                 125             


Gly Pro Gly Arg Arg Tyr Leu Leu Gln Asn Thr Ala Leu Glu Val Phe 
    130                 135                 140                 


Met Ala Asn Arg Thr Ser Val Met Phe Asn Phe Pro Glu Gln Ala Thr 
145                 150                 155                 160 


Val Lys Lys Val Val Tyr Ser Leu Pro Arg Val Gly Val Gly Thr Ser 
                165                 170                 175     


Tyr Gly Leu Pro Gln Ala Gly Pro Gly Pro Gly Lys Ile Glu Pro Asp 
            180                 185                 190         


Met Met Ser Met Glu His Ser Phe Glu Thr Ala Ser His Asp Gly Glu 
        195                 200                 205             


Ala Gly Pro Ser Pro Glu Val Leu Gln Gly Pro Gly Pro Gly Lys Val 
    210                 215                 220                 


Leu Met Ala Ser Thr Ser Tyr Leu Pro Ser Gln Val Thr Glu Met Phe 
225                 230                 235                 240 


Asn Gln Gly Arg Ala Phe Ala Ala Val Arg Leu Pro Phe Cys Gly His 
                245                 250                 255     


Lys Asn Ile Cys Ser Leu Thr Thr Ile Gln Lys Ile Pro Arg Leu Leu 
            260                 265                 270         


Val Gly Pro Gly Pro Gly Met Pro Ala Ala Glu Leu Ala Leu Ser Ala 
        275                 280                 285             


Phe Leu Val Leu Val Phe Leu Trp Val His Ser Leu Arg Arg Leu Leu 
    290                 295                 300                 


Glu Cys Phe Tyr Val Ser Val Phe Ser Asn Ala Ala Ile His Val Val 
305                 310                 315                 320 


Gln Tyr Cys Phe Gly Leu Val Tyr Tyr Gly Pro Gly Pro Gly Leu Leu 
                325                 330                 335     


Glu Leu Leu His Cys Pro Leu Gly His Cys His Leu Cys Ser Glu Pro 
            340                 345                 350         


Met Phe Thr Phe Val Tyr Pro Thr Ile Phe Pro Leu Arg Glu Thr Pro 
        355                 360                 365             


Met Ala Gly Leu His Gln Arg Arg Thr Ser Ile Gly Phe Val Ala Tyr 
    370                 375                 380                 


Cys Gly Pro Gly Pro Gly Ala His Phe Arg Leu Val Ser Lys Glu Lys 
385                 390                 395                 400 


Met Pro Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Arg 
                405                 410                 415     


His Met Ser Phe Tyr Val Arg Thr His Lys Gly Ser Thr Leu Ser Gln 
            420                 425                 430         


Trp Ser Leu Gly Asn Gly Ile Pro Val Gly Pro Gly Pro Gly Gly Arg 
        435                 440                 445             


Thr Gln Gln Met Leu Ile Pro Ala Trp Gln Gln Val Thr Pro Met Ala 
    450                 455                 460                 


Pro Ala Ala Ala Thr Leu Thr Phe Glu Gly Met Ala Gly Ser Gln Arg 
465                 470                 475                 480 


Leu Gly Asp Trp Gly Lys Met Ile Pro His Ser Asn His Tyr Asn Ser 
                485                 490                 495     


Val Gly Pro Gly Pro Gly Glu Leu Gln Leu Val Gln Leu Glu Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Thr Tyr Arg Val Gly Asn Ala Gln Pro Ser Leu Ala 
        515                 520                 525             


Asp Cys Leu Asp Ala Gly Asp Leu Ala Gln Arg Leu Arg Glu His Gly 
    530                 535                 540                 


Ala Glu Val Pro Thr Glu Pro Lys Glu Gly Pro Gly Pro Gly Glu Leu 
545                 550                 555                 560 


Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg Ala Ala Ala Pro 
                565                 570                 575     


Ser Ala Ala Ser Ser Pro Ala Asp Val Gln Ser Leu Lys Lys Ala Met 
            580                 585                 590         


Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu Leu Lys Asn 
        595                 600                 605             


Leu Gly Pro Gly Pro Gly Gly Lys His Asp Arg Asp Leu Leu Ile Gly 
    610                 615                 620                 


Thr Ala Lys His Gly Leu Asn Arg Thr Asp Tyr Tyr Ile Met Asn Gly 
625                 630                 635                 640 


Pro Gln Leu Ser Phe Leu Asp Ala Tyr Arg Asn Tyr Ala Gln His Lys 
                645                 650                 655     


Arg Thr Asp Thr Gln Ala Pro Gly Ser Gly Pro Gly Pro Gly Ile Leu 
            660                 665                 670         


Glu Val Asp Lys Ser Gly Pro Ile Thr Leu Leu Val Gln Gly His Met 
        675                 680                 685             


Glu Gly Glu Val Trp Gly Leu Ser Thr His Pro Tyr Leu Pro Ile Cys 
    690                 695                 700                 


Ala Thr Val Ser Asp Asp Lys Thr Leu Arg Ile Trp Asp Leu Ser Pro 
705                 710                 715                 720 


Ser Gly Pro Gly Pro Gly Met Leu Thr Ala Arg Leu Leu Leu Pro Arg 
                725                 730                 735     


Leu Leu Cys Leu Gln Gly Arg Thr Thr Ser Tyr Ser Thr Ala Ala Val 
            740                 745                 750         


Leu Pro Asn Pro Ile Pro Asn Pro Glu Ile Cys Tyr Asn Lys Leu Phe 
        755                 760                 765             


Ile Asn Asn Glu Trp His Asp Ala Val Gly Pro Gly Pro Gly Glu Val 
    770                 775                 780                 


Ser Gly Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr 
785                 790                 795                 800 


Glu Trp Thr Ser Ser Asn Val Gly Gly Pro Gly Pro Gly Met Thr Glu 
                805                 810                 815     


Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln 
            820                 825                 830         


Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Asp Tyr Lys Asp Asp 
        835                 840                 845             


Asp Asp Lys Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
    850                 855                 860                 


His Asp Ile Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly 
865                 870                 875                 880 


Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser 
                885                 890                 895     


His Ala Gly Tyr Gln Thr Ile 
            900             


<210>  17
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-II polypeptide for MHC-II presentation (recycling endosome 
       target)

<400>  17

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Ala Leu Gln Ala Tyr His Leu Asp Pro Gln Cys Trp Gly 
            20                  25                  30          


Val Asn Val Gln Pro Tyr Ser Gly Ser Pro Ala Asn Val Ala Val Tyr 
        35                  40                  45              


Thr Ala Leu Val Glu Pro His Gly Arg Ile Met Gly Leu Asp Leu Pro 
    50                  55                  60                  


Asp Gly Gly His Leu Thr Gly Pro Gly Pro Gly Asp Thr Asp Glu Ala 
65                  70                  75                  80  


Glu Asp Pro Glu Lys Met Leu Ala Asn Phe Glu Ser Gly Lys His Lys 
                85                  90                  95      


Tyr Arg Gln Thr Ala Met Phe Thr Ala Thr Met Pro Pro Ala Val Glu 
            100                 105                 110         


Arg Leu Ala Arg Ser Tyr Leu Arg Arg Pro Ala Val Val Tyr Gly Pro 
        115                 120                 125             


Gly Pro Gly Arg Arg Tyr Leu Leu Gln Asn Thr Ala Leu Glu Val Phe 
    130                 135                 140                 


Met Ala Asn Arg Thr Ser Val Met Phe Asn Phe Pro Glu Gln Ala Thr 
145                 150                 155                 160 


Val Lys Lys Val Val Tyr Ser Leu Pro Arg Val Gly Val Gly Thr Ser 
                165                 170                 175     


Tyr Gly Leu Pro Gln Ala Gly Pro Gly Pro Gly Lys Ile Glu Pro Asp 
            180                 185                 190         


Met Met Ser Met Glu His Ser Phe Glu Thr Ala Ser His Asp Gly Glu 
        195                 200                 205             


Ala Gly Pro Ser Pro Glu Val Leu Gln Gly Pro Gly Pro Gly Lys Val 
    210                 215                 220                 


Leu Met Ala Ser Thr Ser Tyr Leu Pro Ser Gln Val Thr Glu Met Phe 
225                 230                 235                 240 


Asn Gln Gly Arg Ala Phe Ala Ala Val Arg Leu Pro Phe Cys Gly His 
                245                 250                 255     


Lys Asn Ile Cys Ser Leu Thr Thr Ile Gln Lys Ile Pro Arg Leu Leu 
            260                 265                 270         


Val Gly Pro Gly Pro Gly Met Pro Ala Ala Glu Leu Ala Leu Ser Ala 
        275                 280                 285             


Phe Leu Val Leu Val Phe Leu Trp Val His Ser Leu Arg Arg Leu Leu 
    290                 295                 300                 


Glu Cys Phe Tyr Val Ser Val Phe Ser Asn Ala Ala Ile His Val Val 
305                 310                 315                 320 


Gln Tyr Cys Phe Gly Leu Val Tyr Tyr Gly Pro Gly Pro Gly Leu Leu 
                325                 330                 335     


Glu Leu Leu His Cys Pro Leu Gly His Cys His Leu Cys Ser Glu Pro 
            340                 345                 350         


Met Phe Thr Phe Val Tyr Pro Thr Ile Phe Pro Leu Arg Glu Thr Pro 
        355                 360                 365             


Met Ala Gly Leu His Gln Arg Arg Thr Ser Ile Gly Phe Val Ala Tyr 
    370                 375                 380                 


Cys Gly Pro Gly Pro Gly Ala His Phe Arg Leu Val Ser Lys Glu Lys 
385                 390                 395                 400 


Met Pro Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Arg 
                405                 410                 415     


His Met Ser Phe Tyr Val Arg Thr His Lys Gly Ser Thr Leu Ser Gln 
            420                 425                 430         


Trp Ser Leu Gly Asn Gly Ile Pro Val Gly Pro Gly Pro Gly Gly Arg 
        435                 440                 445             


Thr Gln Gln Met Leu Ile Pro Ala Trp Gln Gln Val Thr Pro Met Ala 
    450                 455                 460                 


Pro Ala Ala Ala Thr Leu Thr Phe Glu Gly Met Ala Gly Ser Gln Arg 
465                 470                 475                 480 


Leu Gly Asp Trp Gly Lys Met Ile Pro His Ser Asn His Tyr Asn Ser 
                485                 490                 495     


Val Gly Pro Gly Pro Gly Glu Leu Gln Leu Val Gln Leu Glu Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Thr Tyr Arg Val Gly Asn Ala Gln Pro Ser Leu Ala 
        515                 520                 525             


Asp Cys Leu Asp Ala Gly Asp Leu Ala Gln Arg Leu Arg Glu His Gly 
    530                 535                 540                 


Ala Glu Val Pro Thr Glu Pro Lys Glu Gly Pro Gly Pro Gly Glu Leu 
545                 550                 555                 560 


Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg Ala Ala Ala Pro 
                565                 570                 575     


Ser Ala Ala Ser Ser Pro Ala Asp Val Gln Ser Leu Lys Lys Ala Met 
            580                 585                 590         


Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu Leu Lys Asn 
        595                 600                 605             


Leu Gly Pro Gly Pro Gly Gly Lys His Asp Arg Asp Leu Leu Ile Gly 
    610                 615                 620                 


Thr Ala Lys His Gly Leu Asn Arg Thr Asp Tyr Tyr Ile Met Asn Gly 
625                 630                 635                 640 


Pro Gln Leu Ser Phe Leu Asp Ala Tyr Arg Asn Tyr Ala Gln His Lys 
                645                 650                 655     


Arg Thr Asp Thr Gln Ala Pro Gly Ser Gly Pro Gly Pro Gly Ile Leu 
            660                 665                 670         


Glu Val Asp Lys Ser Gly Pro Ile Thr Leu Leu Val Gln Gly His Met 
        675                 680                 685             


Glu Gly Glu Val Trp Gly Leu Ser Thr His Pro Tyr Leu Pro Ile Cys 
    690                 695                 700                 


Ala Thr Val Ser Asp Asp Lys Thr Leu Arg Ile Trp Asp Leu Ser Pro 
705                 710                 715                 720 


Ser Gly Pro Gly Pro Gly Met Leu Thr Ala Arg Leu Leu Leu Pro Arg 
                725                 730                 735     


Leu Leu Cys Leu Gln Gly Arg Thr Thr Ser Tyr Ser Thr Ala Ala Val 
            740                 745                 750         


Leu Pro Asn Pro Ile Pro Asn Pro Glu Ile Cys Tyr Asn Lys Leu Phe 
        755                 760                 765             


Ile Asn Asn Glu Trp His Asp Ala Val Gly Pro Gly Pro Gly Glu Val 
    770                 775                 780                 


Ser Gly Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr 
785                 790                 795                 800 


Glu Trp Thr Ser Ser Asn Val Gly Gly Pro Gly Pro Gly Met Thr Glu 
                805                 810                 815     


Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln 
            820                 825                 830         


Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Asp Tyr Lys Asp Asp 
        835                 840                 845             


Asp Asp Lys Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
    850                 855                 860                 


His Asp Ile Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly 
865                 870                 875                 880 


Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Cys 
                885                 890                 895     


Phe Cys 
        


<210>  18
<211>  902
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC-II polypeptide for MHC-II presentation (sorting endosome 
       target)

<400>  18

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu Ala Leu Gln Ala Tyr His Leu Asp Pro Gln Cys Trp Gly 
            20                  25                  30          


Val Asn Val Gln Pro Tyr Ser Gly Ser Pro Ala Asn Val Ala Val Tyr 
        35                  40                  45              


Thr Ala Leu Val Glu Pro His Gly Arg Ile Met Gly Leu Asp Leu Pro 
    50                  55                  60                  


Asp Gly Gly His Leu Thr Gly Pro Gly Pro Gly Asp Thr Asp Glu Ala 
65                  70                  75                  80  


Glu Asp Pro Glu Lys Met Leu Ala Asn Phe Glu Ser Gly Lys His Lys 
                85                  90                  95      


Tyr Arg Gln Thr Ala Met Phe Thr Ala Thr Met Pro Pro Ala Val Glu 
            100                 105                 110         


Arg Leu Ala Arg Ser Tyr Leu Arg Arg Pro Ala Val Val Tyr Gly Pro 
        115                 120                 125             


Gly Pro Gly Arg Arg Tyr Leu Leu Gln Asn Thr Ala Leu Glu Val Phe 
    130                 135                 140                 


Met Ala Asn Arg Thr Ser Val Met Phe Asn Phe Pro Glu Gln Ala Thr 
145                 150                 155                 160 


Val Lys Lys Val Val Tyr Ser Leu Pro Arg Val Gly Val Gly Thr Ser 
                165                 170                 175     


Tyr Gly Leu Pro Gln Ala Gly Pro Gly Pro Gly Lys Ile Glu Pro Asp 
            180                 185                 190         


Met Met Ser Met Glu His Ser Phe Glu Thr Ala Ser His Asp Gly Glu 
        195                 200                 205             


Ala Gly Pro Ser Pro Glu Val Leu Gln Gly Pro Gly Pro Gly Lys Val 
    210                 215                 220                 


Leu Met Ala Ser Thr Ser Tyr Leu Pro Ser Gln Val Thr Glu Met Phe 
225                 230                 235                 240 


Asn Gln Gly Arg Ala Phe Ala Ala Val Arg Leu Pro Phe Cys Gly His 
                245                 250                 255     


Lys Asn Ile Cys Ser Leu Thr Thr Ile Gln Lys Ile Pro Arg Leu Leu 
            260                 265                 270         


Val Gly Pro Gly Pro Gly Met Pro Ala Ala Glu Leu Ala Leu Ser Ala 
        275                 280                 285             


Phe Leu Val Leu Val Phe Leu Trp Val His Ser Leu Arg Arg Leu Leu 
    290                 295                 300                 


Glu Cys Phe Tyr Val Ser Val Phe Ser Asn Ala Ala Ile His Val Val 
305                 310                 315                 320 


Gln Tyr Cys Phe Gly Leu Val Tyr Tyr Gly Pro Gly Pro Gly Leu Leu 
                325                 330                 335     


Glu Leu Leu His Cys Pro Leu Gly His Cys His Leu Cys Ser Glu Pro 
            340                 345                 350         


Met Phe Thr Phe Val Tyr Pro Thr Ile Phe Pro Leu Arg Glu Thr Pro 
        355                 360                 365             


Met Ala Gly Leu His Gln Arg Arg Thr Ser Ile Gly Phe Val Ala Tyr 
    370                 375                 380                 


Cys Gly Pro Gly Pro Gly Ala His Phe Arg Leu Val Ser Lys Glu Lys 
385                 390                 395                 400 


Met Pro Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Arg 
                405                 410                 415     


His Met Ser Phe Tyr Val Arg Thr His Lys Gly Ser Thr Leu Ser Gln 
            420                 425                 430         


Trp Ser Leu Gly Asn Gly Ile Pro Val Gly Pro Gly Pro Gly Gly Arg 
        435                 440                 445             


Thr Gln Gln Met Leu Ile Pro Ala Trp Gln Gln Val Thr Pro Met Ala 
    450                 455                 460                 


Pro Ala Ala Ala Thr Leu Thr Phe Glu Gly Met Ala Gly Ser Gln Arg 
465                 470                 475                 480 


Leu Gly Asp Trp Gly Lys Met Ile Pro His Ser Asn His Tyr Asn Ser 
                485                 490                 495     


Val Gly Pro Gly Pro Gly Glu Leu Gln Leu Val Gln Leu Glu Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Thr Tyr Arg Val Gly Asn Ala Gln Pro Ser Leu Ala 
        515                 520                 525             


Asp Cys Leu Asp Ala Gly Asp Leu Ala Gln Arg Leu Arg Glu His Gly 
    530                 535                 540                 


Ala Glu Val Pro Thr Glu Pro Lys Glu Gly Pro Gly Pro Gly Glu Leu 
545                 550                 555                 560 


Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg Ala Ala Ala Pro 
                565                 570                 575     


Ser Ala Ala Ser Ser Pro Ala Asp Val Gln Ser Leu Lys Lys Ala Met 
            580                 585                 590         


Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu Leu Lys Asn 
        595                 600                 605             


Leu Gly Pro Gly Pro Gly Gly Lys His Asp Arg Asp Leu Leu Ile Gly 
    610                 615                 620                 


Thr Ala Lys His Gly Leu Asn Arg Thr Asp Tyr Tyr Ile Met Asn Gly 
625                 630                 635                 640 


Pro Gln Leu Ser Phe Leu Asp Ala Tyr Arg Asn Tyr Ala Gln His Lys 
                645                 650                 655     


Arg Thr Asp Thr Gln Ala Pro Gly Ser Gly Pro Gly Pro Gly Ile Leu 
            660                 665                 670         


Glu Val Asp Lys Ser Gly Pro Ile Thr Leu Leu Val Gln Gly His Met 
        675                 680                 685             


Glu Gly Glu Val Trp Gly Leu Ser Thr His Pro Tyr Leu Pro Ile Cys 
    690                 695                 700                 


Ala Thr Val Ser Asp Asp Lys Thr Leu Arg Ile Trp Asp Leu Ser Pro 
705                 710                 715                 720 


Ser Gly Pro Gly Pro Gly Met Leu Thr Ala Arg Leu Leu Leu Pro Arg 
                725                 730                 735     


Leu Leu Cys Leu Gln Gly Arg Thr Thr Ser Tyr Ser Thr Ala Ala Val 
            740                 745                 750         


Leu Pro Asn Pro Ile Pro Asn Pro Glu Ile Cys Tyr Asn Lys Leu Phe 
        755                 760                 765             


Ile Asn Asn Glu Trp His Asp Ala Val Gly Pro Gly Pro Gly Glu Val 
    770                 775                 780                 


Ser Gly Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Thr 
785                 790                 795                 800 


Glu Trp Thr Ser Ser Asn Val Gly Gly Pro Gly Pro Gly Met Thr Glu 
                805                 810                 815     


Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln 
            820                 825                 830         


Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Asp Tyr Lys Asp Asp 
        835                 840                 845             


Asp Asp Lys Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp 
    850                 855                 860                 


His Asp Ile Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly 
865                 870                 875                 880 


Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Lys Lys His Cys 
                885                 890                 895     


Ser Tyr Gln Asp Ile Leu 
            900         


