                         SEQUENCE LISTING

<110>  Advantek Serum Laboratories Ltd.
       Wong, Bing Lou
 
<120>  PURIFICATION OF CHONDROITINASE ABC BY AFFINITY CHROMATOGRAPHY

<130>  P1054PC00

<150>  US 15/494,589
<151>  2017-04-24

<150>  CN 201710271643.3
<151>  2017-04-24

<150>  US 15/788,824
<151>  2017-10-20

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  997
<212>  PRT
<213>  Proteus vulgaris

<400>  1

Ala Thr Ser Asn Pro Ala Phe Asp Pro Lys Asn Leu Met Gln Ser Glu 
1               5                   10                  15      


Ile Tyr His Phe Ala Gln Asn Asn Pro Leu Ala Asp Phe Ser Ser Asp 
            20                  25                  30          


Lys Asn Ser Ile Leu Thr Leu Ser Asp Lys Arg Ser Ile Met Gly Asn 
        35                  40                  45              


Gln Ser Leu Leu Trp Lys Trp Lys Gly Gly Ser Ser Phe Thr Leu His 
    50                  55                  60                  


Lys Lys Leu Ile Val Pro Thr Asp Lys Glu Ala Ser Lys Ala Trp Gly 
65                  70                  75                  80  


Arg Ser Ser Thr Pro Val Phe Ser Phe Trp Leu Tyr Asn Glu Lys Pro 
                85                  90                  95      


Ile Asp Gly Tyr Pro Thr Ile Asp Phe Gly Glu Lys Leu Ile Ser Thr 
            100                 105                 110         


Ser Glu Ala Gln Ala Gly Phe Lys Val Lys Leu Asp Phe Thr Gly Trp 
        115                 120                 125             


Arg Ala Val Gly Val Ser Leu Asn Asn Asp Leu Glu Asn Arg Glu Met 
    130                 135                 140                 


Thr Leu Asn Ala Thr Asn Thr Ser Ser Asp Gly Thr Gln Asp Ser Ile 
145                 150                 155                 160 


Gly Arg Ser Leu Gly Ala Lys Val Asp Ser Ile Arg Phe Lys Ala Pro 
                165                 170                 175     


Ser Asn Val Ser Gln Gly Glu Ile Tyr Ile Asp Arg Ile Met Phe Ser 
            180                 185                 190         


Val Asp Asp Ala Arg Tyr Gln Trp Ser Asp Tyr Gln Val Lys Thr Arg 
        195                 200                 205             


Leu Ser Glu Pro Glu Ile Gln Phe His Asn Val Lys Pro Gln Leu Pro 
    210                 215                 220                 


Val Thr Pro Glu Asn Leu Ala Ala Ile Asp Leu Ile Arg Gln Arg Leu 
225                 230                 235                 240 


Ile Asn Glu Phe Val Gly Gly Glu Lys Glu Thr Asn Leu Ala Leu Glu 
                245                 250                 255     


Glu Asn Ile Ser Lys Leu Lys Ser Asp Phe Asp Ala Leu Asn Ile His 
            260                 265                 270         


Thr Leu Ala Asn Gly Gly Thr Gln Gly Arg His Leu Ile Thr Asp Lys 
        275                 280                 285             


Gln Ile Ile Ile Tyr Gln Pro Glu Asn Leu Asn Ser Gln Asp Lys Gln 
    290                 295                 300                 


Leu Phe Asp Asn Tyr Val Ile Leu Gly Asn Tyr Thr Thr Leu Met Phe 
305                 310                 315                 320 


Asn Ile Ser Arg Ala Tyr Val Leu Glu Lys Asp Pro Thr Gln Lys Ala 
                325                 330                 335     


Gln Leu Lys Gln Met Tyr Leu Leu Met Thr Lys His Leu Leu Asp Gln 
            340                 345                 350         


Gly Phe Val Lys Gly Ser Ala Leu Val Thr Thr His His Trp Gly Tyr 
        355                 360                 365             


Ser Ser Arg Trp Trp Tyr Ile Ser Thr Leu Leu Met Ser Asp Ala Leu 
    370                 375                 380                 


Lys Glu Ala Asn Leu Gln Thr Gln Val Tyr Asp Ser Leu Leu Trp Tyr 
385                 390                 395                 400 


Ser Arg Glu Phe Lys Ser Ser Phe Asp Met Lys Val Ser Ala Asp Ser 
                405                 410                 415     


Ser Asp Leu Asp Tyr Phe Asn Thr Leu Ser Arg Gln His Leu Ala Leu 
            420                 425                 430         


Leu Leu Leu Glu Pro Asp Asp Gln Lys Arg Ile Asn Leu Val Asn Thr 
        435                 440                 445             


Phe Ser His Tyr Ile Thr Gly Ala Leu Thr Gln Val Pro Pro Gly Gly 
    450                 455                 460                 


Lys Asp Gly Leu Arg Pro Asp Gly Thr Ala Trp Arg His Glu Gly Asn 
465                 470                 475                 480 


Tyr Pro Gly Tyr Ser Phe Pro Ala Phe Lys Asn Ala Ser Gln Leu Ile 
                485                 490                 495     


Tyr Leu Leu Arg Asp Thr Pro Phe Ser Val Gly Glu Ser Gly Trp Asn 
            500                 505                 510         


Asn Leu Lys Lys Ala Met Val Ser Ala Trp Ile Tyr Ser Asn Pro Glu 
        515                 520                 525             


Val Gly Leu Pro Leu Ala Gly Arg His Pro Phe Asn Ser Pro Ser Leu 
    530                 535                 540                 


Lys Ser Val Ala Gln Gly Tyr Tyr Trp Leu Ala Met Ser Ala Lys Ser 
545                 550                 555                 560 


Ser Pro Asp Lys Thr Leu Ala Ser Ile Tyr Leu Ala Ile Ser Asp Lys 
                565                 570                 575     


Thr Gln Asn Glu Ser Thr Ala Ile Phe Gly Glu Thr Ile Thr Pro Ala 
            580                 585                 590         


Ser Leu Pro Gln Gly Phe Tyr Ala Phe Asn Gly Gly Ala Phe Gly Ile 
        595                 600                 605             


His Arg Trp Gln Asp Lys Met Val Thr Leu Lys Ala Tyr Asn Thr Asn 
    610                 615                 620                 


Val Trp Ser Ser Glu Ile Tyr Asn Lys Asp Asn Arg Tyr Gly Arg Tyr 
625                 630                 635                 640 


Gln Ser His Gly Val Ala Gln Ile Val Ser Asn Gly Ser Gln Leu Ser 
                645                 650                 655     


Gln Gly Tyr Gln Gln Glu Gly Trp Asp Trp Asn Arg Met Gln Gly Ala 
            660                 665                 670         


Thr Thr Ile His Leu Pro Leu Lys Asp Leu Asp Ser Pro Lys Pro His 
        675                 680                 685             


Thr Leu Met Gln Arg Gly Glu Arg Gly Phe Ser Gly Thr Ser Ser Leu 
    690                 695                 700                 


Glu Gly Gln Tyr Gly Met Met Ala Phe Asp Leu Ile Tyr Pro Ala Asn 
705                 710                 715                 720 


Leu Glu Arg Phe Asp Pro Asn Phe Thr Ala Lys Lys Ser Val Leu Ala 
                725                 730                 735     


Ala Asp Asn His Leu Ile Phe Ile Gly Ser Asn Ile Asn Ser Ser Asp 
            740                 745                 750         


Lys Asn Lys Asn Val Glu Thr Thr Leu Phe Gln His Ala Ile Thr Pro 
        755                 760                 765             


Thr Leu Asn Thr Leu Trp Ile Asn Gly Gln Lys Ile Glu Asn Met Pro 
    770                 775                 780                 


Tyr Gln Thr Thr Leu Gln Gln Gly Asp Trp Leu Ile Asp Ser Asn Gly 
785                 790                 795                 800 


Asn Gly Tyr Leu Ile Thr Gln Ala Glu Lys Val Asn Val Ser Arg Gln 
                805                 810                 815     


His Gln Val Ser Ala Glu Asn Lys Asn Arg Gln Pro Thr Glu Gly Asn 
            820                 825                 830         


Phe Ser Ser Ala Trp Ile Asp His Ser Thr Arg Pro Lys Asp Ala Ser 
        835                 840                 845             


Tyr Glu Tyr Met Val Phe Leu Asp Ala Thr Pro Glu Lys Met Gly Glu 
    850                 855                 860                 


Met Ala Gln Lys Phe Arg Glu Asn Asn Gly Leu Tyr Gln Val Leu Arg 
865                 870                 875                 880 


Lys Asp Lys Asp Val His Ile Ile Leu Asp Lys Leu Ser Asn Val Thr 
                885                 890                 895     


Gly Tyr Ala Phe Tyr Gln Pro Ala Ser Ile Glu Asp Lys Trp Ile Lys 
            900                 905                 910         


Lys Val Asn Lys Pro Ala Ile Val Met Thr His Arg Gln Lys Asp Thr 
        915                 920                 925             


Leu Ile Val Ser Ala Val Thr Pro Asp Leu Asn Met Thr Arg Gln Lys 
    930                 935                 940                 


Ala Ala Thr Pro Val Thr Ile Asn Val Thr Ile Asn Gly Lys Trp Gln 
945                 950                 955                 960 


Ser Ala Asp Lys Asn Ser Glu Val Lys Tyr Gln Val Ser Gly Asp Asn 
                965                 970                 975     


Thr Glu Leu Thr Phe Thr Ser Tyr Phe Gly Ile Pro Gln Glu Ile Lys 
            980                 985                 990         


Leu Ser Pro Leu Pro 
        995         


<210>  2
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence is synthesized

<400>  2

Met Ala Thr Ser Asn Pro Ala Phe Asp Pro Lys Asn Leu Met Gln Ser 
1               5                   10                  15      


Glu Ile Tyr His Phe Ala Gln Asn Asn Pro Leu Ala Asp Phe Ser Ser 
            20                  25                  30          


Asp Lys Asn Ser Ile Leu Thr Leu Ser Asp Lys Arg Ser Ile Met Gly 
        35                  40                  45              


Asn Gln Ser Leu Leu Trp Lys Trp Lys Gly Gly Ser Ser Phe Thr Leu 
    50                  55                  60                  


His Lys Lys Leu Ile Val Pro Thr Asp Lys Glu Ala Ser Lys Ala Trp 
65                  70                  75                  80  


Gly Arg Ser Ser Thr Pro Val Phe Ser Phe Trp Leu Tyr Asn Glu Lys 
                85                  90                  95      


Pro Ile Asp Gly Tyr Pro Thr Ile Asp Phe Gly Glu Lys Leu Ile Ser 
            100                 105                 110         


Thr Ser Glu Ala Gln Ala Gly Phe Lys Val Lys Leu Asp Phe Thr Gly 
        115                 120                 125             


Trp Arg Ala Val Gly Val Ser Leu Asn Asn Asp Leu Glu Asn Arg Glu 
    130                 135                 140                 


Met Thr Leu Asn Ala Thr Asn Thr Ser Ser Asp Gly Thr Gln Asp Ser 
145                 150                 155                 160 


Ile Gly Arg Ser Leu Gly Ala Lys Val Asp Ser Ile Arg Phe Lys Ala 
                165                 170                 175     


Pro Ser Asn Val Ser Gln Gly Glu Ile Tyr Ile Asp Arg Ile Met Phe 
            180                 185                 190         


Ser Val Asp Asp Ala Arg Tyr Gln Trp Ser Asp Tyr Gln Val Lys Thr 
        195                 200                 205             


Arg Leu Ser Glu Pro Glu Ile Gln Phe His Asn Val Lys Pro Gln Leu 
    210                 215                 220                 


Pro Val Thr Pro Glu Asn Leu Ala Ala Ile Asp Leu Ile Arg Gln Arg 
225                 230                 235                 240 


Leu Ile Asn Glu Phe Val Gly Gly Glu Lys Glu Thr Asn Leu Ala Leu 
                245                 250                 255     


Glu Glu Asn Ile Ser Lys Leu Lys Ser Asp Phe Asp Ala Leu Asn Ile 
            260                 265                 270         


His Thr Leu Ala Asn Gly Gly Thr Gln Gly Arg His Leu Ile Thr Asp 
        275                 280                 285             


Lys Gln Ile Ile Ile Tyr Gln Pro Glu Asn Leu Asn Ser Gln Asp Lys 
    290                 295                 300                 


Gln Leu Phe Asp Asn Tyr Val Ile Leu Gly Asn Tyr Thr Thr Leu Met 
305                 310                 315                 320 


Phe Asn Ile Ser Arg Ala Tyr Val Leu Glu Lys Asp Pro Thr Gln Lys 
                325                 330                 335     


Ala Gln Leu Lys Gln Met Tyr Leu Leu Met Thr Lys His Leu Leu Asp 
            340                 345                 350         


Gln Gly Phe Val Lys Gly Ser Ala Leu Val Thr Thr His His Trp Gly 
        355                 360                 365             


Tyr Ser Ser Arg Trp Trp Tyr Ile Ser Thr Leu Leu Met Ser Asp Ala 
    370                 375                 380                 


Leu Lys Glu Ala Asn Leu Gln Thr Gln Val Tyr Asp Ser Leu Leu Trp 
385                 390                 395                 400 


Tyr Ser Arg Glu Phe Lys Ser Ser Phe Asp Met Lys Val Ser Ala Asp 
                405                 410                 415     


Ser Ser Asp Leu Asp Tyr Phe Asn Thr Leu Ser Arg Gln His Leu Ala 
            420                 425                 430         


Leu Leu Leu Leu Glu Pro Asp Asp Gln Lys Arg Ile Asn Leu Val Asn 
        435                 440                 445             


Thr Phe Ser His Tyr Ile Thr Gly Ala Leu Thr Gln Val Pro Pro Gly 
    450                 455                 460                 


Gly Lys Asp Gly Leu Arg Pro Asp Gly Thr Ala Trp Arg His Glu Gly 
465                 470                 475                 480 


Asn Tyr Pro Gly Tyr Ser Phe Pro Ala Phe Lys Asn Ala Ser Gln Leu 
                485                 490                 495     


Ile Tyr Leu Leu Arg Asp Thr Pro Phe Ser Val Gly Glu Ser Gly Trp 
            500                 505                 510         


Asn Asn Leu Lys Lys Ala Met Val Ser Ala Trp Ile Tyr Ser Asn Pro 
        515                 520                 525             


Glu Val Gly Leu Pro Leu Ala Gly Arg His Pro Phe Asn Ser Pro Ser 
    530                 535                 540                 


Leu Lys Ser Val Ala Gln Gly Tyr Tyr Trp Leu Ala Met Ser Ala Lys 
545                 550                 555                 560 


Ser Ser Pro Asp Lys Thr Leu Ala Ser Ile Tyr Leu Ala Ile Ser Asp 
                565                 570                 575     


Lys Thr Gln Asn Glu Ser Thr Ala Ile Phe Gly Glu Thr Ile Thr Pro 
            580                 585                 590         


Ala Ser Leu Pro Gln Gly Phe Tyr Ala Phe Asn Gly Gly Ala Phe Gly 
        595                 600                 605             


Ile His Arg Trp Gln Asp Lys Met Val Thr Leu Lys Ala Tyr Asn Thr 
    610                 615                 620                 


Asn Val Trp Ser Ser Glu Ile Tyr Asn Lys Asp Asn Arg Tyr Gly Arg 
625                 630                 635                 640 


Tyr Gln Ser His Gly Val Ala Gln Ile Val Ser Asn Gly Ser Gln Leu 
                645                 650                 655     


Ser Gln Gly Tyr Gln Gln Glu Gly Trp Asp Trp Asn Arg Met Gln Gly 
            660                 665                 670         


Ala Thr Thr Ile His Leu Pro Leu Lys Asp Leu Asp Ser Pro Lys Pro 
        675                 680                 685             


His Thr Leu Met Gln Arg Gly Glu Arg Gly Phe Ser Gly Thr Ser Ser 
    690                 695                 700                 


Leu Glu Gly Gln Tyr Gly Met Met Ala Phe Asp Leu Ile Tyr Pro Ala 
705                 710                 715                 720 


Asn Leu Glu Arg Phe Asp Pro Asn Phe Thr Ala Lys Lys Ser Val Leu 
                725                 730                 735     


Ala Ala Asp Asn His Leu Ile Phe Ile Gly Ser Asn Ile Asn Ser Ser 
            740                 745                 750         


Asp Lys Asn Lys Asn Val Glu Thr Thr Leu Phe Gln His Ala Ile Thr 
        755                 760                 765             


Pro Thr Leu Asn Thr Leu Trp Ile Asn Gly Gln Lys Ile Glu Asn Met 
    770                 775                 780                 


Pro Tyr Gln Thr Thr Leu Gln Gln Gly Asp Trp Leu Ile Asp Ser Asn 
785                 790                 795                 800 


Gly Asn Gly Tyr Leu Ile Thr Gln Ala Glu Lys Val Asn Val Ser Arg 
                805                 810                 815     


Gln His Gln Val Ser Ala Glu Asn Lys Asn Arg Gln Pro Thr Glu Gly 
            820                 825                 830         


Asn Phe Ser Ser Ala Trp Ile Asp His Ser Thr Arg Pro Lys Asp Ala 
        835                 840                 845             


Ser Tyr Glu Tyr Met Val Phe Leu Asp Ala Thr Pro Glu Lys Met Gly 
    850                 855                 860                 


Glu Met Ala Gln Lys Phe Arg Glu Asn Asn Gly Leu Tyr Gln Val Leu 
865                 870                 875                 880 


Arg Lys Asp Lys Asp Val His Ile Ile Leu Asp Lys Leu Ser Asn Val 
                885                 890                 895     


Thr Gly Tyr Ala Phe Tyr Gln Pro Ala Ser Ile Glu Asp Lys Trp Ile 
            900                 905                 910         


Lys Lys Val Asn Lys Pro Ala Ile Val Met Thr His Arg Gln Lys Asp 
        915                 920                 925             


Thr Leu Ile Val Ser Ala Val Thr Pro Asp Leu Asn Met Thr Arg Gln 
    930                 935                 940                 


Lys Ala Ala Thr Pro Val Thr Ile Asn Val Thr Ile Asn Gly Lys Trp 
945                 950                 955                 960 


Gln Ser Ala Asp Lys Asn Ser Glu Val Lys Tyr Gln Val Ser Gly Asp 
                965                 970                 975     


Asn Thr Glu Leu Thr Phe Thr Ser Tyr Phe Gly Ile Pro Gln Glu Ile 
            980                 985                 990         


Lys Leu Ser Pro Leu Pro 
        995             


<210>  3
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence is synthesized

<400>  3

Met Gly Ser Glu Asn Leu Tyr Phe Gln Ala Thr Ser Asn Pro Ala Phe 
1               5                   10                  15      


Asp Pro Lys Asn Leu Met Gln Ser Glu Ile Tyr His Phe Ala Gln Asn 
            20                  25                  30          


Asn Pro Leu Ala Asp Phe Ser Ser Asp Lys Asn Ser Ile Leu Thr Leu 
        35                  40                  45              


Ser Asp Lys Arg Ser Ile Met Gly Asn Gln Ser Leu Leu Trp Lys Trp 
    50                  55                  60                  


Lys Gly Gly Ser Ser Phe Thr Leu His Lys Lys Leu Ile Val Pro Thr 
65                  70                  75                  80  


Asp Lys Glu Ala Ser Lys Ala Trp Gly Arg Ser Ser Thr Pro Val Phe 
                85                  90                  95      


Ser Phe Trp Leu Tyr Asn Glu Lys Pro Ile Asp Gly Tyr Pro Thr Ile 
            100                 105                 110         


Asp Phe Gly Glu Lys Leu Ile Ser Thr Ser Glu Ala Gln Ala Gly Phe 
        115                 120                 125             


Lys Val Lys Leu Asp Phe Thr Gly Trp Arg Ala Val Gly Val Ser Leu 
    130                 135                 140                 


Asn Asn Asp Leu Glu Asn Arg Glu Met Thr Leu Asn Ala Thr Asn Thr 
145                 150                 155                 160 


Ser Ser Asp Gly Thr Gln Asp Ser Ile Gly Arg Ser Leu Gly Ala Lys 
                165                 170                 175     


Val Asp Ser Ile Arg Phe Lys Ala Pro Ser Asn Val Ser Gln Gly Glu 
            180                 185                 190         


Ile Tyr Ile Asp Arg Ile Met Phe Ser Val Asp Asp Ala Arg Tyr Gln 
        195                 200                 205             


Trp Ser Asp Tyr Gln Val Lys Thr Arg Leu Ser Glu Pro Glu Ile Gln 
    210                 215                 220                 


Phe His Asn Val Lys Pro Gln Leu Pro Val Thr Pro Glu Asn Leu Ala 
225                 230                 235                 240 


Ala Ile Asp Leu Ile Arg Gln Arg Leu Ile Asn Glu Phe Val Gly Gly 
                245                 250                 255     


Glu Lys Glu Thr Asn Leu Ala Leu Glu Glu Asn Ile Ser Lys Leu Lys 
            260                 265                 270         


Ser Asp Phe Asp Ala Leu Asn Ile His Thr Leu Ala Asn Gly Gly Thr 
        275                 280                 285             


Gln Gly Arg His Leu Ile Thr Asp Lys Gln Ile Ile Ile Tyr Gln Pro 
    290                 295                 300                 


Glu Asn Leu Asn Ser Gln Asp Lys Gln Leu Phe Asp Asn Tyr Val Ile 
305                 310                 315                 320 


Leu Gly Asn Tyr Thr Thr Leu Met Phe Asn Ile Ser Arg Ala Tyr Val 
                325                 330                 335     


Leu Glu Lys Asp Pro Thr Gln Lys Ala Gln Leu Lys Gln Met Tyr Leu 
            340                 345                 350         


Leu Met Thr Lys His Leu Leu Asp Gln Gly Phe Val Lys Gly Ser Ala 
        355                 360                 365             


Leu Val Thr Thr His His Trp Gly Tyr Ser Ser Arg Trp Trp Tyr Ile 
    370                 375                 380                 


Ser Thr Leu Leu Met Ser Asp Ala Leu Lys Glu Ala Asn Leu Gln Thr 
385                 390                 395                 400 


Gln Val Tyr Asp Ser Leu Leu Trp Tyr Ser Arg Glu Phe Lys Ser Ser 
                405                 410                 415     


Phe Asp Met Lys Val Ser Ala Asp Ser Ser Asp Leu Asp Tyr Phe Asn 
            420                 425                 430         


Thr Leu Ser Arg Gln His Leu Ala Leu Leu Leu Leu Glu Pro Asp Asp 
        435                 440                 445             


Gln Lys Arg Ile Asn Leu Val Asn Thr Phe Ser His Tyr Ile Thr Gly 
    450                 455                 460                 


Ala Leu Thr Gln Val Pro Pro Gly Gly Lys Asp Gly Leu Arg Pro Asp 
465                 470                 475                 480 


Gly Thr Ala Trp Arg His Glu Gly Asn Tyr Pro Gly Tyr Ser Phe Pro 
                485                 490                 495     


Ala Phe Lys Asn Ala Ser Gln Leu Ile Tyr Leu Leu Arg Asp Thr Pro 
            500                 505                 510         


Phe Ser Val Gly Glu Ser Gly Trp Asn Asn Leu Lys Lys Ala Met Val 
        515                 520                 525             


Ser Ala Trp Ile Tyr Ser Asn Pro Glu Val Gly Leu Pro Leu Ala Gly 
    530                 535                 540                 


Arg His Pro Phe Asn Ser Pro Ser Leu Lys Ser Val Ala Gln Gly Tyr 
545                 550                 555                 560 


Tyr Trp Leu Ala Met Ser Ala Lys Ser Ser Pro Asp Lys Thr Leu Ala 
                565                 570                 575     


Ser Ile Tyr Leu Ala Ile Ser Asp Lys Thr Gln Asn Glu Ser Thr Ala 
            580                 585                 590         


Ile Phe Gly Glu Thr Ile Thr Pro Ala Ser Leu Pro Gln Gly Phe Tyr 
        595                 600                 605             


Ala Phe Asn Gly Gly Ala Phe Gly Ile His Arg Trp Gln Asp Lys Met 
    610                 615                 620                 


Val Thr Leu Lys Ala Tyr Asn Thr Asn Val Trp Ser Ser Glu Ile Tyr 
625                 630                 635                 640 


Asn Lys Asp Asn Arg Tyr Gly Arg Tyr Gln Ser His Gly Val Ala Gln 
                645                 650                 655     


Ile Val Ser Asn Gly Ser Gln Leu Ser Gln Gly Tyr Gln Gln Glu Gly 
            660                 665                 670         


Trp Asp Trp Asn Arg Met Gln Gly Ala Thr Thr Ile His Leu Pro Leu 
        675                 680                 685             


Lys Asp Leu Asp Ser Pro Lys Pro His Thr Leu Met Gln Arg Gly Glu 
    690                 695                 700                 


Arg Gly Phe Ser Gly Thr Ser Ser Leu Glu Gly Gln Tyr Gly Met Met 
705                 710                 715                 720 


Ala Phe Asp Leu Ile Tyr Pro Ala Asn Leu Glu Arg Phe Asp Pro Asn 
                725                 730                 735     


Phe Thr Ala Lys Lys Ser Val Leu Ala Ala Asp Asn His Leu Ile Phe 
            740                 745                 750         


Ile Gly Ser Asn Ile Asn Ser Ser Asp Lys Asn Lys Asn Val Glu Thr 
        755                 760                 765             


Thr Leu Phe Gln His Ala Ile Thr Pro Thr Leu Asn Thr Leu Trp Ile 
    770                 775                 780                 


Asn Gly Gln Lys Ile Glu Asn Met Pro Tyr Gln Thr Thr Leu Gln Gln 
785                 790                 795                 800 


Gly Asp Trp Leu Ile Asp Ser Asn Gly Asn Gly Tyr Leu Ile Thr Gln 
                805                 810                 815     


Ala Glu Lys Val Asn Val Ser Arg Gln His Gln Val Ser Ala Glu Asn 
            820                 825                 830         


Lys Asn Arg Gln Pro Thr Glu Gly Asn Phe Ser Ser Ala Trp Ile Asp 
        835                 840                 845             


His Ser Thr Arg Pro Lys Asp Ala Ser Tyr Glu Tyr Met Val Phe Leu 
    850                 855                 860                 


Asp Ala Thr Pro Glu Lys Met Gly Glu Met Ala Gln Lys Phe Arg Glu 
865                 870                 875                 880 


Asn Asn Gly Leu Tyr Gln Val Leu Arg Lys Asp Lys Asp Val His Ile 
                885                 890                 895     


Ile Leu Asp Lys Leu Ser Asn Val Thr Gly Tyr Ala Phe Tyr Gln Pro 
            900                 905                 910         


Ala Ser Ile Glu Asp Lys Trp Ile Lys Lys Val Asn Lys Pro Ala Ile 
        915                 920                 925             


Val Met Thr His Arg Gln Lys Asp Thr Leu Ile Val Ser Ala Val Thr 
    930                 935                 940                 


Pro Asp Leu Asn Met Thr Arg Gln Lys Ala Ala Thr Pro Val Thr Ile 
945                 950                 955                 960 


Asn Val Thr Ile Asn Gly Lys Trp Gln Ser Ala Asp Lys Asn Ser Glu 
                965                 970                 975     


Val Lys Tyr Gln Val Ser Gly Asp Asn Thr Glu Leu Thr Phe Thr Ser 
            980                 985                 990         


Tyr Phe Gly Ile Pro Gln Glu Ile  Lys Leu Ser Pro Leu  Pro 
        995                 1000                 1005     


<210>  4
<211>  3046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized in the lab

<400>  4
atgggcagcg aaaacctgta tttccaggcc accagcaatc ctgcatttga tcctaaaaat       60

ctgatgcagt cagaaattta ccattttgca caaaataacc cattagcaga cttctcatca      120

gataaaaact caatactaac gttatctgat aaacgtagca ttatgggaaa ccaatctctt      180

ttatggaaat ggaaaggtgg tagtagcttt actttacata aaaaactgat tgtccccacc      240

gataaagaag catctaaagc atggggacgc tcatctaccc ccgttttctc attttggctt      300

tacaatgaaa aaccgattga tggttatctt actatcgatt tcggagaaaa actcatttca      360

accagtgagg ctcaggcagg ctttaaagta aaattagatt tcactggctg gcgtgctgtg      420

ggagtctctt taaataacga tcttgaaaat cgagagatga ccttaaatgc aaccaatacc      480

tcctctgatg gtactcaaga cagcattggg cgttctttag gtgctaaagt cgatagtatt      540

cgttttaaag cgccttctaa tgtgagtcag ggtgaaatct atatcgaccg tattatgttt      600

tctgtcgatg atgctcgcta ccaatggtct gattatcaag taaaaactcg cttatcagaa      660

cctgaaattc aatttcacaa cgtaaagcca caactacctg taacacctga aaatttagcg      720

gccattgatc ttattcgcca acgtctaatt aatgaatttg tcggaggtga aaaagagaca      780

aacctcgcat tagaagagaa tatcagcaaa ttaaaaagtg atttcgatgc tcttaatatt      840

cacactttag caaatggtgg aacgcaaggc agacatctga tcactgataa acaaatcatt      900

atttatcaac cagagaatct taactcccaa gataaacaac tatttgataa ttatgttatt      960

ttaggtaatt acacgacatt aatgtttaat attagccgtg cttatgtgct ggaaaaagat     1020

cccacacaaa aggcgcaact aaagcagatg tacttattaa tgacaaagca tttattagat     1080

caaggctttg ttaaagggag tgctttagtg acaacccatc actggggata cagttctcgt     1140

tggtggtata tttccacgtt attaatgtct gatgcactaa aagaagcgaa cctacaaact     1200

caagtttatg attcattact gtggtattca cgtgagttta aaagtagttt tgatatgaaa     1260

gtaagtgctg atagctctga tctagattat ttcaatacct tatctcgcca acatttagcc     1320

ttattattac tagagcctga tgatcaaaag cgtatcaact tagttaatac tttcagccat     1380

tatatcactg gcgcattaac gcaagtgcca ccgggtggta aagatggttt acgccctgat     1440

ggtacagcat ggcgacatga aggcaactat ccgggctact ctttcccagc ctttaaaaat     1500

gcctctcagc ttatttattt attacgcgat acaccatttt cagtgggtga aagtggttgg     1560

aataacctga aaaaagcgat ggtttcagcg tggatctaca gtaatccaga agttggatta     1620

ccgcttgcag gaagacaccc ttttaactca ccttcgttaa aatcagtcgc tcaaggctat     1680

tactggcttg ccatgtctgc aaaatcatcg cctgataaaa cacttgcatc tatttatctt     1740

gcgattagtg ataaaacaca aaatgaatca actgctattt ttggagaaac tattacacca     1800

gcgtctttac ctcaaggttt ctatgccttt aatggcggtg cttttggtat tcatcgttgg     1860

caagataaaa tggtgacact gaaagcttat aacaccaatg tttggtcatc tgaaatttat     1920

aacaaagata accgttatgg ccgttaccaa agtcatggtg tcgctcaaat agtgagtaat     1980

ggctcgcagc tttcacaggg ctatcagcaa gaaggttggg attggaatag aatgcaaggg     2040

gcaaccacta ttcaccttcc tcttaaagac ttagacagtc ctaaacctca taccttaatg     2100

caacgtggag agcgtggatt tagcggaaca tcatcccttg aaggtcaata tggcatgatg     2160

gcattcgatc ttatttatcc cgccaatctt gagcgttttg atcctaattt cactgcgaaa     2220

aagagtgtat tagccgctga taatcactta atttttattg gtagcaatat aaatagtagt     2280

gataaaaata aaaatgttga aacgacctta ttccaacatg ccattactcc aacattaaat     2340

accctttgga ttaatggaca aaagatagaa aacatgcctt atcaaacaac acttcaacaa     2400

ggtgattggt taattgatag caatggcaat ggttacttaa ttactcaagc agaaaaagta     2460

aatgtaagtc gccaacatca ggtttcagcg gaaaataaaa atcgccaacc gacagaagga     2520

aactttagct cggcatggat cgatcacagc actcgcccca aagatgccag ttatgagtat     2580

atggtctttt tagatgcgac acctgaaaaa atgggagaga tggcacaaaa attccgtgaa     2640

aataatgggt tatatcaggt tcttcgtaag gataaagacg ttcatattat tctcgataaa     2700

ctcagcaatg taacgggata tgccttttat cagccagcat caattgaaga caaatggatc     2760

aaaaaggtta ataaacctgc aattgtgatg actcatcgac aaaaagacac tcttattgtc     2820

agtgcagtta cacctgattt aaatatgact cgccaaaaag cagcaactcc tgtcaccatc     2880

aatgtcacga ttaatggcaa atggcaatct gctgataaaa atagtgaagt gaaatatcag     2940

gtttctggtg ataacactga actgacgttt acgagttact ttggtattcc acaagaaatc     3000

aaactctcgc cactcccttg actcgagtcg cagatccggc tgctaa                    3046


