                         SEQUENCE LISTING

<110>  PRABHAKAR, et al.
 
<120>  SYNERGISTIC COMBINATION OF NUCLEIC ACID OLIGONUCLEOTIDES AND 
       ANTHRACYCLINE CHEMOTHERAPEUTICS

<130>  JIVANA 4 PCT

<150>  US 62/489,056

<151>  2017-04-24

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  1
cggcgaatct atgacaatc                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  2
cggcgaaucu augacaauc                                                    19


<210>  3
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  3
cggcgaatct atgacaatct tcaagagaga ttgtcataga ttcgccg                     47


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  4
gauugucaua gauucgccgt t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  5
uugcuaagcg ucggucaaut t                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  6
agccccaata tggctttccc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  7
ctgatccact aacgccctcc                                                   20


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  8
atctggcacc acaccttcta caatgagctg cg                                     32


<210>  9
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  9
cgtcatactc ctgcttgctg atccacatct gc                                     32


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  10
gauugucaua gauucgccg                                                    19


<210>  11
<211>  6020
<212>  DNA
<213>  Homo sapiens

<400>  11
gatttcagcg ctaaggcgtc ggcggtgcac ctcacgtgca tgtgtagcat gccttggttt       60

ttcctttggc atctgaaaaa ggcacaacct gaaagaccta gaacccagtg tcggtcccca      120

ggccctttgg gacaggaaga gaagagccgt gtggccgcgg ggaggatgtc ctgaggcggg      180

gctgtcctcg cggactgact ggactccatc tcccagcggg cgccgcggcg cggccacgcc      240

cccccactcc ccgcgcgcgc ccggtggaga cttcgatttt cagaattcct cctgggaatg      300

ctgactcctt gcttggtgcc ctgatgcttc tctgagataa actgatgaat tggaaccatg      360

gtgcaaaaga agaagttctg tcctcggtta cttgactatc tagtgatcgt aggggccagg      420

cacccgagca gtgatagcgt ggcccagact cctgaattgc tacggcgata ccccttggag      480

gatcacactg agtttcccct gcccccagat gtagtgttct tctgccagcc cgagggctgc      540

ctgagcgtgc ggcagcggcg catgagcctt cgggatgata cctcttttgt cttcaccctc      600

actgacaagg acactggagt cacgcgatat ggcatctgtg ttaacttcta ccgctccttc      660

caaaagcgaa tctctaagga gaagggggaa ggtggggcag ggtcccgtgg gaaggaagga      720

acccatgcca cctgtgcctc agaagagggt ggcactgaga gctcagagag tggctcatcc      780

ctgcagcctc tcagtgctga ctctacccct gatgtgaacc agtctcctcg gggcaaacgc      840

cgggccaagg cggggagccg ctcccgcaac agtactctca cgtccctgtg cgtgctcagc      900

cactaccctt tcttctccac cttccgagag tgtttgtata ctctcaagcg cctggtggac      960

tgctgtagtg agcgccttct gggcaagaaa ctgggcatcc ctcgaggcgt acaaagggac     1020

accatgtggc ggatctttac tggatcgctg ctggtagagg agaagtcaag tgcccttctg     1080

catgaccttc gagagattga ggcctggatc tatcgattgc tgcgctcccc agtacccgtc     1140

tctgggcaga agcgagtaga catcgaggtc ctaccccaag agctccagcc agctctgacc     1200

tttgctcttc cagacccatc tcgattcacc ctagtggatt tcccactgca ccttcccttg     1260

gaacttctag gtgtggacgc ctgtctccag gtgctaacct gcattctgtt agagcacaag     1320

gtggtgctac agtcccgaga ctacaatgca ctctccatgt ctgtgatggc attcgtggca     1380

atgatctacc cactggagta tatgtttcct gtcatcccgc tgctacccac ctgcatggca     1440

tcagcagagc agctgctgtt ggctccaacc ccgtacatca ttggggttcc tgccagcttc     1500

ttcctctaca aactggactt caaaatgcct gatgatgtat ggctagtgga tctggacagc     1560

aatagggtga ttgcccccac caatgcagaa gtgctgccta tcctgccaga accagaatca     1620

ctagagctga aaaagcattt aaagcaggcc ttggccagca tgagtctcaa cacccagccc     1680

atcctcaatc tggagaaatt tcatgagggc caggagatcc cccttctctt gggaaggcct     1740

tctaatgacc tgcagtccac accgtccact gaattcaacc cactcatcta tggcaatgat     1800

gtggattctg tggatgttgc aaccagggtt gccatggtac ggttcttcaa ttccgccaac     1860

gtgctgcagg gatttcagat gcacacgcgt accctgcgcc tctttcctcg gcctgtggta     1920

gcttttcaag ctggctcctt tctagcctca cgtccccggc agactccttt tgccgagaaa     1980

ttggccagga ctcaggctgt ggagtacttt ggggaatgga tccttaaccc caccaactat     2040

gcctttcagc gaattcacaa caatatgttt gatccagccc tgattggtga caagccaaag     2100

tggtatgctc atcagctgca gcctatccac tatcgcgtct atgacagcaa ttcccagctg     2160

gctgaggccc tgagtgtacc accagagcgg gactctgact ccgaacctac tgatgatagt     2220

ggcagtgata gtatggatta tgacgattca agctcttctt actcctccct tggtgacttt     2280

gtcagtgaaa tgatgaaatg tgacattaat ggtgatactc ccaatgtgga ccctctgaca     2340

catgcagcac tgggggatgc cagcgaggtg gagattgacg agctgcagaa tcagaaggaa     2400

gcagaagagc ctggcccaga cagtgagaac tctcaggaaa accccccact gcgctccagc     2460

tctagcacca cagccagcag cagccccagc actgtcatcc acggagccaa ctctgaacct     2520

gctgactcta cggagatgga tgataaggca gcagtaggcg tctccaagcc cctcccttcc     2580

gtgcctccca gcattggcaa atcgaacgtg gacagacgtc aggcagaaat tggagagggg     2640

tcagtgcgcc ggcgaatcta tgacaatcca tacttcgagc cccaatatgg ctttccccct     2700

gaggaagatg aggatgagca gggggaaagt tacactcccc gattcagcca acatgtcagt     2760

ggcaatcggg ctcaaaagct gctgcggccc aacagcttga gactggcaag tgactcagat     2820

gcagagtcag actctcgggc aagctctccc aactccaccg tctccaacac cagcaccgag     2880

ggcttcgggg gcatcatgtc ttttgccagc agcctctatc ggaaccacag taccagcttc     2940

agtctttcaa acctcacact gcccaccaaa ggtgcccgag agaaggccac gcccttcccc     3000

agtctgaaag gaaacaggag ggcgttagtg gatcagaagt catctgtcat taaacacagc     3060

ccaacagtga aaagagaacc tccatcaccc cagggtcgat ccagcaattc tagtgagaac     3120

cagcagttcc tgaaggaggt ggtgcacagc gtgctggacg gccagggagt tggctggctc     3180

aacatgaaaa aggtgcgccg gctgctggag agcgagcagc tgcgagtctt tgtcctgagc     3240

aagctgaacc gcatggtgca gtcagaggac gatgcccggc aggacatcat cccggatgtg     3300

gagatcagtc ggaaggtgta caagggaatg ttagacctcc tcaagtgtac agtcctcagc     3360

ttggagcagt cctatgccca cgcgggtctg ggtggcatgg ccagcatctt tgggcttttg     3420

gagattgccc agacccacta ctatagtaaa gaaccagaca agcggaagag aagtccaaca     3480

gaaagtgtaa ataccccagt tggcaaggat cctggcctag ctgggcgggg ggacccaaag     3540

gctatggcac aactgagagt tccacaactg ggacctcggg caccaagtgc cacaggaaag     3600

ggtcctaagg aactggacac cagaagttta aaggaagaaa attttatagc atctattggg     3660

cctgaagtaa tcaaacctgt ctttgacctt ggtgagacag aggagaaaaa gtcccagatc     3720

agcgcagaca gtggtgtgag cctgacgtct agttcccaga ggactgatca agactctgtc     3780

atcggcgtga gtccagctgt tatgatccgc agctcaagtc aggattctga agttagcacc     3840

gtggtgagta atagctctgg agagaccctt ggagctgaca gtgacttgag cagcaatgca     3900

ggtgatggac caggtggcga gggcagtgtt cacctggcaa gctctcgggg cactttgtct     3960

gatagtgaaa ttgagaccaa ctctgccaca agcaccatct ttggtaaagc ccacagcttg     4020

aagccaagca taaaggagaa gctggcaggc agccccattc gtacttctga agatgtgagc     4080

cagcgagtct atctctatga gggactccta ggcaaagagc gttctacttt atgggaccaa     4140

atgcaattct gggaagatgc cttcttagat gctgtgatgt tggagagaga agggatgggt     4200

atggaccagg gtccccagga aatgatcgac aggtacctgt cccttggaga acatgaccgg     4260

aagcgcctgg aagatgatga agatcgcttg ctggccacac ttctgcacaa cctcatctcc     4320

tacatgctgc tgatgaaggt aaataagaat gacatccgca agaaggtgag gcgcctaatg     4380

ggaaagtcgc acattgggct tgtgtacagc cagcaaatca atgaggtgct tgatcagctg     4440

gcgaacctga atggacgcga tctctctatc tggtccagtg gcagccggca catgaagaag     4500

cagacatttg tggtacatgc agggacagat acaaacggag atatcttttt catggaggtg     4560

tgcgatgact gtgtggtgtt gcgtagtaac atcggaacag tgtatgagcg ctggtggtac     4620

gagaagctca tcaacatgac ctactgtccc aagacgaagg tgttgtgctt gtggcgtaga     4680

aatggctctg agacccagct caacaagttc tatactaaaa agtgtcggga gctgtactac     4740

tgtgtgaagg acagcatgga gcgcgctgcc gcccgacagc aaagcatcaa acccggacct     4800

gaattgggtg gcgagttccc tgtgcaggac ctgaagactg gtgagggtgg cctgctgcag     4860

gtgaccctgg aagggatcaa cctcaaattc atgcacaatc aggttttcat agagctgaat     4920

cacattaaaa agtgcaatac agttcgaggc gtctttgtcc tggaggaatt tgttcctgaa     4980

attaaagaag tggtgagcca caagtacaag acaccaatgg cccacgaaat ctgctactcc     5040

gtattatgtc tcttctcgta cgtggctgca gttcatagca gtgaggaaga tctcagaacc     5100

ccgccccggc ctgtctctag ctgatggaga ggggctacgc agctgcccca gcccagggca     5160

cgcccctggc cccttgctgt tcccaagtgc acgatgctgc tgtgactgag gagtggatga     5220

tgctcgtgtg tcctctgcaa gccccctgct gtggcttggt tggttaccgg ttatgtgtcc     5280

ctctgagtgt gtcttgagcg tgtccacctt ctccctctcc actcccagaa gaccaaactg     5340

ccttcccctc agggctcaag aatgtgtaca gtctgtgggg ccggtgtgaa cccactattt     5400

tgtgtccttg agacatttgt gttgtggttc cttgtccttg tccctggcgt tataactgtc     5460

cactgcaaga gtctggctct cccttctctg tgacccggca tgactgggcg cctggagcag     5520

tttcactctg tgaggagtga gggaaccctg gggctcaccc tctcagagga agggcacaga     5580

gaggaaggga agaattgggg ggcagccgga gtgagtggca gcctccctgc ttccttctgc     5640

attcccaagc cggcagctac tgcccagggc ccgcagtgtt ggctgctgcc tgccacagcc     5700

tctgtgactg cagtggagcg gcgaattccc tgtggcctgc cacgccttcg gcatcagagg     5760

atggagtggt cgaggctagt ggagtcccag ggaccgctgg ctgctctgcc tgagcatcag     5820

ggagggggca ggaaagacca agctgggttt gcacatctgt ctgcaggctg tctctccagg     5880

cacggggtgt caggagggag agacagcctg ggtatgggca agaaatgact gtaaatattt     5940

cagccccaca ttatttatag aaaatgtaca gttgtgtgaa tgtgaaataa atgtcctcaa     6000

ctcccaaaaa aaaaaaaaaa                                                 6020


<210>  12
<211>  1588
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val 
1               5                   10                  15      


Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro 
            20                  25                  30          


Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu 
        35                  40                  45              


Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val 
    50                  55                  60                  


Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr 
65                  70                  75                  80  


Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn 
                85                  90                  95      


Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly 
            100                 105                 110         


Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser 
        115                 120                 125             


Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro 
    130                 135                 140                 


Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys 
145                 150                 155                 160 


Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser 
                165                 170                 175     


Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys 
            180                 185                 190         


Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu 
        195                 200                 205             


Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp 
    210                 215                 220                 


Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu 
225                 230                 235                 240 


Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg 
                245                 250                 255     


Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu 
            260                 265                 270         


Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser 
        275                 280                 285             


Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu 
    290                 295                 300                 


Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His 
305                 310                 315                 320 


Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val 
                325                 330                 335     


Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val 
            340                 345                 350         


Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu 
        355                 360                 365             


Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp 
385                 390                 395                 400 


Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu 
                405                 410                 415     


Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu 
            420                 425                 430         


Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe 
        435                 440                 445             


His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp 
    450                 455                 460                 


Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn 
465                 470                 475                 480 


Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe 
                485                 490                 495     


Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr 
            500                 505                 510         


Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe 
        515                 520                 525             


Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg 
    530                 535                 540                 


Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn 
545                 550                 555                 560 


Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile 
                565                 570                 575     


Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr 
            580                 585                 590         


Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro 
        595                 600                 605             


Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp 
    610                 615                 620                 


Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp 
625                 630                 635                 640 


Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn 
                645                 650                 655     


Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu 
            660                 665                 670         


Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp 
        675                 680                 685             


Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr 
    690                 695                 700                 


Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu 
705                 710                 715                 720 


Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser 
                725                 730                 735     


Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp 
            740                 745                 750         


Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr 
        755                 760                 765             


Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp 
    770                 775                 780                 


Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val 
785                 790                 795                 800 


Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu 
                805                 810                 815     


Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn 
            820                 825                 830         


Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser 
        835                 840                 845             


Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser 
    850                 855                 860                 


Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe 
865                 870                 875                 880 


Pro Ser Leu Lys Gly Asn Arg Arg Ala Leu Val Asp Gln Lys Ser Ser 
                885                 890                 895     


Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro Pro Ser Pro Gln 
            900                 905                 910         


Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe Leu Lys Glu Val 
        915                 920                 925             


Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp Leu Asn Met Lys 
    930                 935                 940                 


Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg Val Phe Val Leu 
945                 950                 955                 960 


Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp Ala Arg Gln Asp 
                965                 970                 975     


Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr Lys Gly Met Leu 
            980                 985                 990         


Asp Leu Leu Lys Cys Thr Val Leu  Ser Leu Glu Gln Ser  Tyr Ala His 
        995                 1000                 1005             


Ala Gly  Leu Gly Gly Met Ala  Ser Ile Phe Gly Leu  Leu Glu Ile 
    1010                 1015                 1020             


Ala Gln  Thr His Tyr Tyr Ser  Lys Glu Pro Asp Lys  Arg Lys Arg 
    1025                 1030                 1035             


Ser Pro  Thr Glu Ser Val Asn  Thr Pro Val Gly Lys  Asp Pro Gly 
    1040                 1045                 1050             


Leu Ala  Gly Arg Gly Asp Pro  Lys Ala Met Ala Gln  Leu Arg Val 
    1055                 1060                 1065             


Pro Gln  Leu Gly Pro Arg Ala  Pro Ser Ala Thr Gly  Lys Gly Pro 
    1070                 1075                 1080             


Lys Glu  Leu Asp Thr Arg Ser  Leu Lys Glu Glu Asn  Phe Ile Ala 
    1085                 1090                 1095             


Ser Ile  Gly Pro Glu Val Ile  Lys Pro Val Phe Asp  Leu Gly Glu 
    1100                 1105                 1110             


Thr Glu  Glu Lys Lys Ser Gln  Ile Ser Ala Asp Ser  Gly Val Ser 
    1115                 1120                 1125             


Leu Thr  Ser Ser Ser Gln Arg  Thr Asp Gln Asp Ser  Val Ile Gly 
    1130                 1135                 1140             


Val Ser  Pro Ala Val Met Ile  Arg Ser Ser Ser Gln  Asp Ser Glu 
    1145                 1150                 1155             


Val Ser  Thr Val Val Ser Asn  Ser Ser Gly Glu Thr  Leu Gly Ala 
    1160                 1165                 1170             


Asp Ser  Asp Leu Ser Ser Asn  Ala Gly Asp Gly Pro  Gly Gly Glu 
    1175                 1180                 1185             


Gly Ser  Val His Leu Ala Ser  Ser Arg Gly Thr Leu  Ser Asp Ser 
    1190                 1195                 1200             


Glu Ile  Glu Thr Asn Ser Ala  Thr Ser Thr Ile Phe  Gly Lys Ala 
    1205                 1210                 1215             


His Ser  Leu Lys Pro Ser Ile  Lys Glu Lys Leu Ala  Gly Ser Pro 
    1220                 1225                 1230             


Ile Arg  Thr Ser Glu Asp Val  Ser Gln Arg Val Tyr  Leu Tyr Glu 
    1235                 1240                 1245             


Gly Leu  Leu Gly Lys Glu Arg  Ser Thr Leu Trp Asp  Gln Met Gln 
    1250                 1255                 1260             


Phe Trp  Glu Asp Ala Phe Leu  Asp Ala Val Met Leu  Glu Arg Glu 
    1265                 1270                 1275             


Gly Met  Gly Met Asp Gln Gly  Pro Gln Glu Met Ile  Asp Arg Tyr 
    1280                 1285                 1290             


Leu Ser  Leu Gly Glu His Asp  Arg Lys Arg Leu Glu  Asp Asp Glu 
    1295                 1300                 1305             


Asp Arg  Leu Leu Ala Thr Leu  Leu His Asn Leu Ile  Ser Tyr Met 
    1310                 1315                 1320             


Leu Leu  Met Lys Val Asn Lys  Asn Asp Ile Arg Lys  Lys Val Arg 
    1325                 1330                 1335             


Arg Leu  Met Gly Lys Ser His  Ile Gly Leu Val Tyr  Ser Gln Gln 
    1340                 1345                 1350             


Ile Asn  Glu Val Leu Asp Gln  Leu Ala Asn Leu Asn  Gly Arg Asp 
    1355                 1360                 1365             


Leu Ser  Ile Trp Ser Ser Gly  Ser Arg His Met Lys  Lys Gln Thr 
    1370                 1375                 1380             


Phe Val  Val His Ala Gly Thr  Asp Thr Asn Gly Asp  Ile Phe Phe 
    1385                 1390                 1395             


Met Glu  Val Cys Asp Asp Cys  Val Val Leu Arg Ser  Asn Ile Gly 
    1400                 1405                 1410             


Thr Val  Tyr Glu Arg Trp Trp  Tyr Glu Lys Leu Ile  Asn Met Thr 
    1415                 1420                 1425             


Tyr Cys  Pro Lys Thr Lys Val  Leu Cys Leu Trp Arg  Arg Asn Gly 
    1430                 1435                 1440             


Ser Glu  Thr Gln Leu Asn Lys  Phe Tyr Thr Lys Lys  Cys Arg Glu 
    1445                 1450                 1455             


Leu Tyr  Tyr Cys Val Lys Asp  Ser Met Glu Arg Ala  Ala Ala Arg 
    1460                 1465                 1470             


Gln Gln  Ser Ile Lys Pro Gly  Pro Glu Leu Gly Gly  Glu Phe Pro 
    1475                 1480                 1485             


Val Gln  Asp Leu Lys Thr Gly  Glu Gly Gly Leu Leu  Gln Val Thr 
    1490                 1495                 1500             


Leu Glu  Gly Ile Asn Leu Lys  Phe Met His Asn Gln  Val Phe Ile 
    1505                 1510                 1515             


Glu Leu  Asn His Ile Lys Lys  Cys Asn Thr Val Arg  Gly Val Phe 
    1520                 1525                 1530             


Val Leu  Glu Glu Phe Val Pro  Glu Ile Lys Glu Val  Val Ser His 
    1535                 1540                 1545             


Lys Tyr  Lys Thr Pro Met Ala  His Glu Ile Cys Tyr  Ser Val Leu 
    1550                 1555                 1560             


Cys Leu  Phe Ser Tyr Val Ala  Ala Val His Ser Ser  Glu Glu Asp 
    1565                 1570                 1575             


Leu Arg  Thr Pro Pro Arg Pro  Val Ser Ser 
    1580                 1585             


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
cggcgaaucu augacaauct t                                                 21


