                         SEQUENCE LISTING

<110>  JUNO THERAPEUTICS GMBH
       SCHMIDT, Thomas
       STEMBERGER, Christian
       KOWSKI, Tom
       PRENTICE, Ken
 
<120>  OLIGOMERIC PARTICLE REAGENTS AND METHODS OF USE THEREOF

<130>  735042008540

<140> Not Yet Assigned    
<141> Concurrently Herewith

<150>  US 62/491,245
<151>  2017-04-27

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Streptavidin

<400>  1

Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly 
1               5                   10                  15      


Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr 
            20                  25                  30          


Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val Gly 
        35                  40                  45              


Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro 
    50                  55                  60                  


Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys 
65                  70                  75                  80  


Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr 
                85                  90                  95      


Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser 
            100                 105                 110         


Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp 
        115                 120                 125             


Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys 
    130                 135                 140                 


Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 


<210>  2
<211>  126
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Minimal streptavidin

<400>  2

Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
1               5                   10                  15      


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser 
            20                  25                  30          


Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
        35                  40                  45              


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
    50                  55                  60                  


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
65                  70                  75                  80  


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
                85                  90                  95      


Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val 
            100                 105                 110         


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125     


<210>  3
<211>  159
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Mutein Streptavidin Val44-Thr45-Ala46-Arg47

<400>  3

Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly 
1               5                   10                  15      


Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr 
            20                  25                  30          


Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr Ala Arg Gly 
        35                  40                  45              


Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro 
    50                  55                  60                  


Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys 
65                  70                  75                  80  


Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr 
                85                  90                  95      


Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser 
            100                 105                 110         


Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp 
        115                 120                 125             


Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys 
    130                 135                 140                 


Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 


<210>  4
<211>  126
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Mutein Streptavidin Val44-Thr45-Ala46-Arg47

<400>  4

Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
1               5                   10                  15      


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr 
            20                  25                  30          


Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
        35                  40                  45              


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
    50                  55                  60                  


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
65                  70                  75                  80  


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
                85                  90                  95      


Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val 
            100                 105                 110         


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125     


<210>  5
<211>  159
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47

<400>  5

Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly 
1               5                   10                  15      


Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr 
            20                  25                  30          


Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Ile Gly Ala Arg Gly 
        35                  40                  45              


Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro 
    50                  55                  60                  


Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys 
65                  70                  75                  80  


Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr 
                85                  90                  95      


Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser 
            100                 105                 110         


Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp 
        115                 120                 125             


Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys 
    130                 135                 140                 


Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 


<210>  6
<211>  126
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47

<400>  6

Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
1               5                   10                  15      


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Ile Gly 
            20                  25                  30          


Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
        35                  40                  45              


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
    50                  55                  60                  


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
65                  70                  75                  80  


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
                85                  90                  95      


Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val 
            100                 105                 110         


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125     


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Streptavidin binding peptide, Strep-tag

<400>  7

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-tag

<400>  8

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  9
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Streptavidin Binding peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is selected from glutamine, asparagine and methionine

<400>  9

His Pro Xaa 
1           


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Streptavidin-binding peptide

<400>  10

His Pro Gln Phe 
1               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Streptavidin-binding peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Trp, Lys or Arg;

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Gly or Glu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Gly, Lys or Arg

<400>  11

Xaa Xaa His Pro Gln Phe Xaa Xaa 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Streptavidin-binding peptide


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Gly or Glu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Gly, Lys or Arg

<400>  12

Trp Xaa His Pro Gln Phe Xaa Xaa 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequential modules of streptavidin-binding peptide


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is any amino acid

<220>
<221>  REPEAT
<222>  (9)..(9)
<223>  Xaa is repeated 8 or 12 times

<400>  13

Trp Ser His Pro Gln Phe Glu Lys Xaa Trp Ser His Pro Gln Phe Glu 
1               5                   10                  15      


Lys 
    


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequential modules of streptavidin-binding peptide


<220>
<221>  REPEAT
<222>  (9)..(12)
<223>  repeated 2 or 3 times

<400>  14

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Trp Ser His Pro 
1               5                   10                  15      


Gln Phe Glu Lys 
            20  


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Twin-Strep-tag

<400>  15

Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Twin-Strep-tag

<400>  16

Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30  


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Twin-Strep-tag

<400>  17

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
            20                  25              


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Twin-Strep-tag

<400>  18

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Trp Ser His Pro Gln Phe Glu Lys 
            20                  


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Twin-Strep-tag

<400>  19

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25              


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-tag

<400>  20

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSV-G-tag

<400>  21

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV-tag

<400>  22

Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T7 epitope

<400>  23

Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV epitope

<400>  24

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc epitope

<400>  25

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5-tag

<400>  26

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  27
<211>  126
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47 and Glu117, Gly120, 
       Try121 (mutein m1-9)

<400>  27

Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
1               5                   10                  15      


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr 
            20                  25                  30          


Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
        35                  40                  45              


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
    50                  55                  60                  


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
65                  70                  75                  80  


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
                85                  90                  95      


Leu Thr Ser Gly Thr Thr Glu Glu Asn Ala Gly Tyr Ser Thr Leu Val 
            100                 105                 110         


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125     


<210>  28
<211>  139
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  misc_feature
<223>  Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47 and Glu117, Gly120, 
       Try121 (mutein m1-9)

<400>  28

Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly 
1               5                   10                  15      


Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr 
            20                  25                  30          


Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr Ala Arg Gly 
        35                  40                  45              


Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro 
    50                  55                  60                  


Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys 
65                  70                  75                  80  


Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr 
                85                  90                  95      


Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser 
            100                 105                 110         


Gly Thr Thr Glu Glu Asn Ala Gly Tyr Ser Thr Leu Val Gly His Asp 
        115                 120                 125             


Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
    130                 135                 


<210>  29
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy chain of Fab fragment m13B8.2

<400>  29

Ala Met Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30          


Thr Phe Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Val Ile Trp Ala Ser Gly Ile Thr Asp Tyr Asn Val Pro 
    50                  55                  60                  


Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Phe Lys Leu Asn Ser Leu Gln Pro Asp Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Asn Asp Pro Gly Thr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Ser 
    210                 215                 220                 


Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                245                 250             


<210>  30
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light chain of Fab Fragment m13B8.2

<400>  30

Ala Met Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Glu Thr Val Thr Phe Thr Cys Arg Ala Ser Glu Met Ile Tyr 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
        35                  40                  45              


Leu Val His Asp Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Gly Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Thr Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Ala His Tyr Gly Asn 
                85                  90                  95      


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Ile 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gly Ser 
    210                 215             


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light chain of anti-CD3 antibody OKT3

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  32
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light chain of anti-CD3 antibody OKT3

<400>  32

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     


<210>  33
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy chain of anti-CD28 antibody CD28.3

<400>  33

Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Arg 
1               5                   10                  15      


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Ile Ile His 
            20                  25                  30          


Trp Ile Lys Leu Arg Ser Gly Gln Gly Leu Glu Trp Ile Gly Trp Phe 
        35                  40                  45              


Tyr Pro Gly Ser Asn Asp Ile Gln Tyr Asn Ala Lys Phe Lys Gly Lys 
    50                  55                  60                  


Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Glu Leu 
65                  70                  75                  80  


Thr Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg 
                85                  90                  95      


Asp Asp Phe Ser Gly Tyr Asp Ala Leu Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val 
        115     


<210>  34
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light chain of anti-CD28 antibody CD28.3

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Asn Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr His Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Cys 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAT tag

<400>  35

His Asn His Arg His Lys His Gly Gly Gly Cys 
1               5                   10      


<210>  36
<211>  1145
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LFA-1alpha

<400>  36

Tyr Asn Leu Asp Val Arg Gly Ala Arg Ser Phe Ser Pro Pro Arg Ala 
1               5                   10                  15      


Gly Arg His Phe Gly Tyr Arg Val Leu Gln Val Gly Asn Gly Val Ile 
            20                  25                  30          


Val Gly Ala Pro Gly Glu Gly Asn Ser Thr Gly Ser Leu Tyr Gln Cys 
        35                  40                  45              


Gln Ser Gly Thr Gly His Cys Leu Pro Val Thr Leu Arg Gly Ser Asn 
    50                  55                  60                  


Tyr Thr Ser Lys Tyr Leu Gly Met Thr Leu Ala Thr Asp Pro Thr Asp 
65                  70                  75                  80  


Gly Ser Ile Leu Ala Cys Asp Pro Gly Leu Ser Arg Thr Cys Asp Gln 
                85                  90                  95      


Asn Thr Tyr Leu Ser Gly Leu Cys Tyr Leu Phe Arg Gln Asn Leu Gln 
            100                 105                 110         


Gly Pro Met Leu Gln Gly Arg Pro Gly Phe Gln Glu Cys Ile Lys Gly 
        115                 120                 125             


Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln Pro 
    130                 135                 140                 


Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys Lys 
145                 150                 155                 160 


Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr Ser 
                165                 170                 175     


Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp Pro 
            180                 185                 190         


Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn Thr 
        195                 200                 205             


Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu Leu 
    210                 215                 220                 


Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp Gly 
225                 230                 235                 240 


Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile Arg 
                245                 250                 255     


Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln Glu 
            260                 265                 270         


Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys Ile 
        275                 280                 285             


Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln Lys 
    290                 295                 300                 


Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys Gln Asp Leu Thr Ser Phe 
305                 310                 315                 320 


Asn Met Glu Leu Ser Ser Ser Gly Ile Ser Ala Asp Leu Ser Arg Gly 
                325                 330                 335     


His Ala Val Val Gly Ala Val Gly Ala Lys Asp Trp Ala Gly Gly Phe 
            340                 345                 350         


Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp Thr Phe Ile Gly Asn Glu 
        355                 360                 365             


Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr Leu Gly Tyr Thr Val Thr 
    370                 375                 380                 


Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu Leu Ala Ser Gly Ala Pro 
385                 390                 395                 400 


Arg Tyr Gln His Met Gly Arg Val Leu Leu Phe Gln Glu Pro Gln Gly 
                405                 410                 415     


Gly Gly His Trp Ser Gln Val Gln Thr Ile His Gly Thr Gln Ile Gly 
            420                 425                 430         


Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val Asp Val Asp Gln Asp Gly 
        435                 440                 445             


Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro Leu Phe Tyr Gly Glu Gln 
    450                 455                 460                 


Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg Arg Gln Leu Gly Phe Glu 
465                 470                 475                 480 


Glu Val Ser Glu Leu Gln Gly Asp Pro Gly Tyr Pro Leu Gly Arg Phe 
                485                 490                 495     


Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile Asn Gly Asp Gly Leu Val 
            500                 505                 510         


Asp Val Ala Val Gly Ala Pro Leu Glu Glu Gln Gly Ala Val Tyr Ile 
        515                 520                 525             


Phe Asn Gly Arg His Gly Gly Leu Ser Pro Gln Pro Ser Gln Arg Ile 
    530                 535                 540                 


Glu Gly Thr Gln Val Leu Ser Gly Ile Gln Trp Phe Gly Arg Ser Ile 
545                 550                 555                 560 


His Gly Val Lys Asp Leu Glu Gly Asp Gly Leu Ala Asp Val Ala Val 
                565                 570                 575     


Gly Ala Glu Ser Gln Met Ile Val Leu Ser Ser Arg Pro Val Val Asp 
            580                 585                 590         


Met Val Thr Leu Met Ser Phe Ser Pro Ala Glu Ile Pro Val His Glu 
        595                 600                 605             


Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys Met Lys Glu Gly Val Asn 
    610                 615                 620                 


Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu Ile Pro Gln Phe Gln Gly 
625                 630                 635                 640 


Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu Gln Leu Asp Gly His Arg 
                645                 650                 655     


Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly Arg His Glu Leu Arg Arg 
            660                 665                 670         


Asn Ile Ala Val Thr Thr Ser Met Ser Cys Thr Asp Phe Ser Phe His 
        675                 680                 685             


Phe Pro Val Cys Val Gln Asp Leu Ile Ser Pro Ile Asn Val Ser Leu 
    690                 695                 700                 


Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr Pro Arg Asp Gln Arg Ala 
705                 710                 715                 720 


Gln Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro Ser Leu His Ser Glu 
                725                 730                 735     


Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly Glu Asp Lys Lys Cys 
            740                 745                 750         


Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala Arg Ser Arg Ala Leu 
        755                 760                 765             


Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu Leu Ser Leu Ser Asn 
    770                 775                 780                 


Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp Leu His Phe Pro Pro 
785                 790                 795                 800 


Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys Pro His Ser Gln Ile 
                805                 810                 815     


Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser Arg Leu Leu Ser Arg 
            820                 825                 830         


Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe Lys Ala Gly His Ser 
        835                 840                 845             


Val Ala Leu Gln Met Met Phe Asn Thr Leu Val Asn Ser Ser Trp Gly 
    850                 855                 860                 


Asp Ser Val Glu Leu His Ala Asn Val Thr Cys Asn Asn Glu Asp Ser 
865                 870                 875                 880 


Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile Ile Pro Ile Leu Tyr 
                885                 890                 895     


Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp Ser Thr Leu Tyr Val 
            900                 905                 910         


Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln Val Lys His Met Tyr 
        915                 920                 925             


Gln Val Arg Ile Gln Pro Ser Ile His Asp His Asn Ile Pro Thr Leu 
    930                 935                 940                 


Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser Glu Gly Pro Ile Thr 
945                 950                 955                 960 


His Gln Trp Ser Val Gln Met Glu Pro Pro Val Pro Cys His Tyr Glu 
                965                 970                 975     


Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly Ala 
            980                 985                 990         


Leu Phe Arg Cys Pro Val Val Phe  Arg Gln Glu Ile Leu  Val Gln Val 
        995                 1000                 1005             


Ile Gly  Thr Leu Glu Leu Val  Gly Glu Ile Glu Ala  Ser Ser Met 
    1010                 1015                 1020             


Phe Ser  Leu Cys Ser Ser Leu  Ser Ile Ser Phe Asn  Ser Ser Lys 
    1025                 1030                 1035             


His Phe  His Leu Tyr Gly Ser  Asn Ala Ser Leu Ala  Gln Val Val 
    1040                 1045                 1050             


Met Lys  Val Asp Val Val Tyr  Glu Lys Gln Met Leu  Tyr Leu Tyr 
    1055                 1060                 1065             


Val Leu  Ser Gly Ile Gly Gly  Leu Leu Leu Leu Leu  Leu Ile Phe 
    1070                 1075                 1080             


Ile Val  Leu Tyr Lys Val Gly  Phe Phe Lys Arg Asn  Leu Lys Glu 
    1085                 1090                 1095             


Lys Met  Glu Ala Gly Arg Gly  Val Pro Asn Gly Ile  Pro Ala Glu 
    1100                 1105                 1110             


Asp Ser  Glu Gln Leu Ala Ser  Gly Gln Glu Ala Gly  Asp Pro Gly 
    1115                 1120                 1125             


Cys Leu  Lys Pro Leu His Glu  Lys Asp Ser Glu Ser  Gly Gly Gly 
    1130                 1135                 1140             


Lys Asp  
    1145 


<210>  37
<211>  747
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LFA-1beta

<400>  37

Gln Glu Cys Thr Lys Phe Lys Val Ser Ser Cys Arg Glu Cys Ile Glu 
1               5                   10                  15      


Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys Leu Asn Phe Thr Gly Pro 
            20                  25                  30          


Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr Arg Pro Gln Leu Leu Met 
        35                  40                  45              


Arg Gly Cys Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala Glu 
    50                  55                  60                  


Thr Gln Glu Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln Lys 
65                  70                  75                  80  


Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val Thr 
                85                  90                  95      


Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp Leu Tyr Tyr Leu Met Asp 
            100                 105                 110         


Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg Asn Val Lys Lys Leu Gly 
        115                 120                 125             


Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile Thr Glu Ser Gly Arg Ile 
    130                 135                 140                 


Gly Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr 
145                 150                 155                 160 


His Pro Asp Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys 
                165                 170                 175     


Gln Pro Pro Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser 
            180                 185                 190         


Asn Gln Phe Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu 
        195                 200                 205             


Asp Ala Pro Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys 
    210                 215                 220                 


Pro Glu Glu Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala 
225                 230                 235                 240 


Thr Asp Asp Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile 
                245                 250                 255     


Leu Thr Pro Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys 
            260                 265                 270         


Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys 
        275                 280                 285             


Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met 
    290                 295                 300                 


Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val 
305                 310                 315                 320 


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Lys Asn 
                325                 330                 335     


Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu 
            340                 345                 350         


Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val 
        355                 360                 365             


Thr His Arg Asn Gln Pro Arg Gly Asp Cys Asp Gly Val Gln Ile Asn 
    370                 375                 380                 


Val Pro Ile Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln 
385                 390                 395                 400 


Glu Gln Ser Phe Val Ile Arg Ala Leu Gly Phe Thr Asp Ile Val Thr 
                405                 410                 415     


Val Gln Val Leu Pro Gln Cys Glu Cys Arg Cys Arg Asp Gln Ser Arg 
            420                 425                 430         


Asp Arg Ser Leu Cys His Gly Lys Gly Phe Leu Glu Cys Gly Ile Cys 
        435                 440                 445             


Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn Cys Glu Cys Gln Thr Gln 
    450                 455                 460                 


Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser Cys Arg Lys Asp Asn Asn 
465                 470                 475                 480 


Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys Val Cys Gly Gln Cys Leu 
                485                 490                 495     


Cys His Thr Ser Asp Val Pro Gly Lys Leu Ile Tyr Gly Gln Tyr Cys 
            500                 505                 510         


Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr Asn Gly Gln Val Cys Gly 
        515                 520                 525             


Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly Lys Cys Arg Cys His Pro 
    530                 535                 540                 


Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu Arg Thr Thr Glu Gly Cys 
545                 550                 555                 560 


Leu Asn Pro Arg Arg Val Glu Cys Ser Gly Arg Gly Arg Cys Arg Cys 
                565                 570                 575     


Asn Val Cys Glu Cys His Ser Gly Tyr Gln Leu Pro Leu Cys Gln Glu 
            580                 585                 590         


Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys Tyr Ile Ser Cys Ala Glu 
        595                 600                 605             


Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly Lys Asn Cys Ser Ala Ala 
    610                 615                 620                 


Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro Val Lys Gly Arg Thr Cys 
625                 630                 635                 640 


Lys Glu Arg Asp Ser Glu Gly Cys Trp Val Ala Tyr Thr Leu Glu Gln 
                645                 650                 655     


Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr Val Asp Glu Ser Arg Glu 
            660                 665                 670         


Cys Val Ala Gly Pro Asn Ile Ala Ala Ile Val Gly Gly Thr Val Ala 
        675                 680                 685             


Gly Ile Val Leu Ile Gly Ile Leu Leu Leu Val Ile Trp Lys Ala Leu 
    690                 695                 700                 


Ile His Leu Ser Asp Leu Arg Glu Tyr Arg Arg Phe Glu Lys Glu Lys 
705                 710                 715                 720 


Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro Leu Phe Lys Ser Ala Thr 
                725                 730                 735     


Thr Thr Val Met Asn Pro Lys Phe Ala Glu Ser 
            740                 745         


<210>  38
<211>  344
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  L-selectin

<400>  38

Asp Phe Leu Ala His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser 
1               5                   10                  15      


Glu Lys Pro Met Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn 
            20                  25                  30          


Tyr Thr Asp Leu Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu 
        35                  40                  45              


Glu Lys Thr Leu Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg 
    50                  55                  60                  


Lys Ile Gly Gly Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr 
65                  70                  75                  80  


Glu Glu Ala Glu Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn 
                85                  90                  95      


Lys Glu Asp Cys Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly 
            100                 105                 110         


Lys Trp Asn Asp Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr 
        115                 120                 125             


Thr Ala Ser Cys Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val 
    130                 135                 140                 


Glu Ile Ile Asn Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly 
145                 150                 155                 160 


Pro Gln Cys Gln Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu 
                165                 170                 175     


Leu Gly Thr Met Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser 
            180                 185                 190         


Ser Gln Cys Ala Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile 
        195                 200                 205             


Glu Glu Thr Thr Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro 
    210                 215                 220                 


Thr Cys Gln Val Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly 
225                 230                 235                 240 


Ile Met Asn Cys Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala 
                245                 250                 255     


Cys Thr Phe Ile Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys 
            260                 265                 270         


Thr Ile Cys Glu Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys 
        275                 280                 285             


Gln Lys Leu Asp Lys Ser Phe Ser Met Ile Lys Glu Gly Asp Tyr Asn 
    290                 295                 300                 


Pro Leu Phe Ile Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ile Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys Ser 
                325                 330                 335     


Lys Arg Ser Met Asn Asp Pro Tyr 
            340                 


<210>  39
<211>  715
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VCAM-1

<400>  39

Phe Lys Ile Glu Thr Thr Pro Glu Ser Arg Tyr Leu Ala Gln Ile Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Thr Cys Ser Thr Thr Gly Cys Glu Ser Pro Phe 
            20                  25                  30          


Phe Ser Trp Arg Thr Gln Ile Asp Ser Pro Leu Asn Gly Lys Val Thr 
        35                  40                  45              


Asn Glu Gly Thr Thr Ser Thr Leu Thr Met Asn Pro Val Ser Phe Gly 
    50                  55                  60                  


Asn Glu His Ser Tyr Leu Cys Thr Ala Thr Cys Glu Ser Arg Lys Leu 
65                  70                  75                  80  


Glu Lys Gly Ile Gln Val Glu Ile Tyr Ser Phe Pro Lys Asp Pro Glu 
                85                  90                  95      


Ile His Leu Ser Gly Pro Leu Glu Ala Gly Lys Pro Ile Thr Val Lys 
            100                 105                 110         


Cys Ser Val Ala Asp Val Tyr Pro Phe Asp Arg Leu Glu Ile Asp Leu 
        115                 120                 125             


Leu Lys Gly Asp His Leu Met Lys Ser Gln Glu Phe Leu Glu Asp Ala 
    130                 135                 140                 


Asp Arg Lys Ser Leu Glu Thr Lys Ser Leu Glu Val Thr Phe Thr Pro 
145                 150                 155                 160 


Val Ile Glu Asp Ile Gly Lys Val Leu Val Cys Arg Ala Lys Leu His 
                165                 170                 175     


Ile Asp Glu Met Asp Ser Val Pro Thr Val Arg Gln Ala Val Lys Glu 
            180                 185                 190         


Leu Gln Val Tyr Ile Ser Pro Lys Asn Thr Val Ile Ser Val Asn Pro 
        195                 200                 205             


Ser Thr Lys Leu Gln Glu Gly Gly Ser Val Thr Met Thr Cys Ser Ser 
    210                 215                 220                 


Glu Gly Leu Pro Ala Pro Glu Ile Phe Trp Ser Lys Lys Leu Asp Asn 
225                 230                 235                 240 


Gly Asn Leu Gln His Leu Ser Gly Asn Ala Thr Leu Thr Leu Ile Ala 
                245                 250                 255     


Met Arg Met Glu Asp Ser Gly Ile Tyr Val Cys Glu Gly Val Asn Leu 
            260                 265                 270         


Ile Gly Lys Asn Arg Lys Glu Val Glu Leu Ile Val Gln Glu Lys Pro 
        275                 280                 285             


Phe Thr Val Glu Ile Ser Pro Gly Pro Arg Ile Ala Ala Gln Ile Gly 
    290                 295                 300                 


Asp Ser Val Met Leu Thr Cys Ser Val Met Gly Cys Glu Ser Pro Ser 
305                 310                 315                 320 


Phe Ser Trp Arg Thr Gln Ile Asp Ser Pro Leu Ser Gly Lys Val Arg 
                325                 330                 335     


Ser Glu Gly Thr Asn Ser Thr Leu Thr Leu Ser Pro Val Ser Phe Glu 
            340                 345                 350         


Asn Glu His Ser Tyr Leu Cys Thr Val Thr Cys Gly His Lys Lys Leu 
        355                 360                 365             


Glu Lys Gly Ile Gln Val Glu Leu Tyr Ser Phe Pro Arg Asp Pro Glu 
    370                 375                 380                 


Ile Glu Met Ser Gly Gly Leu Val Asn Gly Ser Ser Val Thr Val Ser 
385                 390                 395                 400 


Cys Lys Val Pro Ser Val Tyr Pro Leu Asp Arg Leu Glu Ile Glu Leu 
                405                 410                 415     


Leu Lys Gly Glu Thr Ile Leu Glu Asn Ile Glu Phe Leu Glu Asp Thr 
            420                 425                 430         


Asp Met Lys Ser Leu Glu Asn Lys Ser Leu Glu Met Thr Phe Ile Pro 
        435                 440                 445             


Thr Ile Glu Asp Thr Gly Lys Ala Leu Val Cys Gln Ala Lys Leu His 
    450                 455                 460                 


Ile Asp Asp Met Glu Phe Glu Pro Lys Gln Arg Gln Ser Thr Gln Thr 
465                 470                 475                 480 


Leu Tyr Val Asn Val Ala Pro Arg Asp Thr Thr Val Leu Val Ser Pro 
                485                 490                 495     


Ser Ser Ile Leu Glu Glu Gly Ser Ser Val Asn Met Thr Cys Leu Ser 
            500                 505                 510         


Gln Gly Phe Pro Ala Pro Lys Ile Leu Trp Ser Arg Gln Leu Pro Asn 
        515                 520                 525             


Gly Glu Leu Gln Pro Leu Ser Glu Asn Ala Thr Leu Thr Leu Ile Ser 
    530                 535                 540                 


Thr Lys Met Glu Asp Ser Gly Val Tyr Leu Cys Glu Gly Ile Asn Gln 
545                 550                 555                 560 


Ala Gly Arg Ser Arg Lys Glu Val Glu Leu Ile Ile Gln Val Thr Pro 
                565                 570                 575     


Lys Asp Ile Lys Leu Thr Ala Phe Pro Ser Glu Ser Val Lys Glu Gly 
            580                 585                 590         


Asp Thr Val Ile Ile Ser Cys Thr Cys Gly Asn Val Pro Glu Thr Trp 
        595                 600                 605             


Ile Ile Leu Lys Lys Lys Ala Glu Thr Gly Asp Thr Val Leu Lys Ser 
    610                 615                 620                 


Ile Asp Gly Ala Tyr Thr Ile Arg Lys Ala Gln Leu Lys Asp Ala Gly 
625                 630                 635                 640 


Val Tyr Glu Cys Glu Ser Lys Asn Lys Val Gly Ser Gln Leu Arg Ser 
                645                 650                 655     


Leu Thr Leu Asp Val Gln Gly Arg Glu Asn Asn Lys Asp Tyr Phe Ser 
            660                 665                 670         


Pro Glu Leu Leu Val Leu Tyr Phe Ala Ser Ser Leu Ile Ile Pro Ala 
        675                 680                 685             


Ile Gly Met Ile Ile Tyr Phe Ala Arg Lys Ala Asn Met Lys Gly Ser 
    690                 695                 700                 


Tyr Ser Leu Val Glu Ala Gln Lys Ser Lys Val 
705                 710                 715 


<210>  40
<211>  999
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VLA-4

<400>  40

Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His Asn 
1               5                   10                  15      


Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn Arg 
            20                  25                  30          


Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala Ser 
        35                  40                  45              


Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn Pro 
    50                  55                  60                  


Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu Pro 
65                  70                  75                  80  


Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly Val 
                85                  90                  95      


Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys Gly 
            100                 105                 110         


His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu Pro 
        115                 120                 125             


Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu Ser 
    130                 135                 140                 


Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly Glu 
145                 150                 155                 160 


Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys Asp 
                165                 170                 175     


Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser Leu 
            180                 185                 190         


Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp Lys 
        195                 200                 205             


Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly Ala 
    210                 215                 220                 


Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala Pro 
225                 230                 235                 240 


Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu Lys 
                245                 250                 255     


Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser Tyr 
            260                 265                 270         


Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe Ser 
        275                 280                 285             


Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu Gly 
    290                 295                 300                 


Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn Ala 
305                 310                 315                 320 


Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe Gly 
                325                 330                 335     


Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu Asp 
            340                 345                 350         


Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile Tyr 
        355                 360                 365             


Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln Arg 
    370                 375                 380                 


Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln Ser 
385                 390                 395                 400 


Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val Ala 
                405                 410                 415     


Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg Pro 
            420                 425                 430         


Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn Arg 
        435                 440                 445             


Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile Asp 
    450                 455                 460                 


Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr Ile 
465                 470                 475                 480 


Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu Ser 
                485                 490                 495     


Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile Thr 
            500                 505                 510         


Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His Gln 
        515                 520                 525             


Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln Ile 
    530                 535                 540                 


Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser Thr 
545                 550                 555                 560 


Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu Lys 
                565                 570                 575     


Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His Glu 
            580                 585                 590         


Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu Lys 
        595                 600                 605             


Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr Leu 
    610                 615                 620                 


Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu Thr 
625                 630                 635                 640 


Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile Leu 
                645                 650                 655     


Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser Gly 
            660                 665                 670         


Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His Leu 
        675                 680                 685             


Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser Arg 
    690                 695                 700                 


Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn Glu 
705                 710                 715                 720 


Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile Pro 
                725                 730                 735     


Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro Thr 
            740                 745                 750         


Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys Met 
        755                 760                 765             


Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn Ser 
    770                 775                 780                 


Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe Ser 
785                 790                 795                 800 


Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr Thr 
                805                 810                 815     


Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu Gln 
            820                 825                 830         


Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu Ser 
        835                 840                 845             


Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His Cys 
    850                 855                 860                 


Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu Ala 
865                 870                 875                 880 


Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met Asp 
                885                 890                 895     


Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro Glu 
            900                 905                 910         


Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala His 
        915                 920                 925             


Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe Thr 
    930                 935                 940                 


Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu Leu 
945                 950                 955                 960 


Leu Ile Ser Tyr Val Met Trp Lys Ala Gly Phe Phe Lys Arg Gln Tyr 
                965                 970                 975     


Lys Ser Ile Leu Gln Glu Glu Asn Arg Arg Asp Ser Trp Ser Tyr Ile 
            980                 985                 990         


Asn Ser Lys Ser Asn Asp Asp 
        995                 


<210>  41
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-2

<400>  41

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  42
<211>  129
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-4

<400>  42

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  43
<211>  152
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-7

<400>  43

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  44
<211>  160
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-10

<400>  44

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  45
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-15

<400>  45

Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
1               5                   10                  15      


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser 
    130             


<210>  46
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-17

<400>  46

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  47
<211>  103
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CXCL9

<400>  47

Thr Pro Val Val Arg Lys Gly Arg Cys Ser Cys Ile Ser Thr Asn Gln 
1               5                   10                  15      


Gly Thr Ile His Leu Gln Ser Leu Lys Asp Leu Lys Gln Phe Ala Pro 
            20                  25                  30          


Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile Ala Thr Leu Lys Asn Gly 
        35                  40                  45              


Val Gln Thr Cys Leu Asn Pro Asp Ser Ala Asp Val Lys Glu Leu Ile 
    50                  55                  60                  


Lys Lys Trp Glu Lys Gln Val Ser Gln Lys Lys Lys Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Lys His Gln Lys Lys Lys Val Leu Lys Val Arg Lys Ser Gln Arg 
                85                  90                  95      


Ser Arg Gln Lys Lys Thr Thr 
            100             


<210>  48
<211>  77
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CXCL10

<400>  48

Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser Asn 
1               5                   10                  15      


Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro Ala 
            20                  25                  30          


Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys Lys 
        35                  40                  45              


Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn Leu 
    50                  55                  60                  


Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg Ser Pro 
65                  70                  75          


<210>  49
<211>  77
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CCL19

<400>  49

Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser Val Thr Gln Lys Pro 
1               5                   10                  15      


Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr Leu Leu Ile Lys Asp 
            20                  25                  30          


Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr Leu Arg Gly Arg Gln 
        35                  40                  45              


Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu Arg Ile Ile Gln Arg 
    50                  55                  60                  


Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg Ser Ser 
65                  70                  75          


<210>  50
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CCL21

<400>  50

Ser Asp Gly Gly Ala Gln Asp Cys Cys Leu Lys Tyr Ser Gln Arg Lys 
1               5                   10                  15      


Ile Pro Ala Lys Val Val Arg Ser Tyr Arg Lys Gln Glu Pro Ser Leu 
            20                  25                  30          


Gly Cys Ser Ile Pro Ala Ile Leu Phe Leu Pro Arg Lys Arg Ser Gln 
        35                  40                  45              


Ala Glu Leu Cys Ala Asp Pro Lys Glu Leu Trp Val Gln Gln Leu Met 
    50                  55                  60                  


Gln His Leu Asp Lys Thr Pro Ser Pro Gln Lys Pro Ala Gln Gly Cys 
65                  70                  75                  80  


Arg Lys Asp Arg Gly Ala Ser Lys Thr Gly Lys Lys Gly Lys Gly Ser 
                85                  90                  95      


Lys Gly Cys Lys Arg Thr Glu Arg Ser Gln Thr Pro Lys Gly Pro 
            100                 105                 110     


<210>  51
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CCL25

<400>  51

Gln Gly Val Phe Glu Asp Cys Cys Leu Ala Tyr His Tyr Pro Ile Gly 
1               5                   10                  15      


Trp Ala Val Leu Arg Arg Ala Trp Thr Tyr Arg Ile Gln Glu Val Ser 
            20                  25                  30          


Gly Ser Cys Asn Leu Pro Ala Ala Ile Phe Tyr Leu Pro Lys Arg His 
        35                  40                  45              


Arg Lys Val Cys Gly Asn Pro Lys Ser Arg Glu Val Gln Arg Ala Met 
    50                  55                  60                  


Lys Leu Leu Asp Ala Arg Asn Lys Val Phe Ala Lys Leu His His Asn 
65                  70                  75                  80  


Thr Gln Thr Phe Gln Ala Gly Pro His Ala Val Lys Lys Leu Ser Ser 
                85                  90                  95      


Gly Asn Ser Lys Leu Ser Ser Ser Lys Phe Ser Asn Pro Ile Ser Ser 
            100                 105                 110         


Ser Lys Arg Asn Val Ser Leu Leu Ile Ser Ala Asn Ser Gly Leu 
        115                 120                 125         


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD16 antibody 3G8 VH

<400>  52

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Arg Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  53
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD16 antibody 3G8 VL

<400>  53

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  54
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFA-1alpha Extracellular domain (ECD)

<400>  54

Tyr Asn Leu Asp Val Arg Gly Ala Arg Ser Phe Ser Pro Pro Arg Ala 
1               5                   10                  15      


Gly Arg His Phe Gly Tyr Arg Val Leu Gln Val Gly Asn Gly Val Ile 
            20                  25                  30          


Val Gly Ala Pro Gly Glu Gly Asn Ser Thr Gly Ser Leu Tyr Gln Cys 
        35                  40                  45              


Gln Ser Gly Thr Gly His Cys Leu Pro Val Thr Leu Arg Gly Ser Asn 
    50                  55                  60                  


Tyr Thr Ser Lys Tyr Leu Gly Met Thr Leu Ala Thr Asp Pro Thr Asp 
65                  70                  75                  80  


Gly Ser Ile Leu Ala Cys Asp Pro Gly Leu Ser Arg Thr Cys Asp Gln 
                85                  90                  95      


Asn Thr Tyr Leu Ser Gly Leu Cys Tyr Leu Phe Arg Gln Asn Leu Gln 
            100                 105                 110         


Gly Pro Met Leu Gln Gly Arg Pro Gly Phe Gln Glu Cys Ile Lys Gly 
        115                 120                 125             


Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln Pro 
    130                 135                 140                 


Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys Lys 
145                 150                 155                 160 


Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr Ser 
                165                 170                 175     


Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys Asp Pro 
            180                 185                 190         


Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn Thr 
        195                 200                 205             


Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu Leu 
    210                 215                 220                 


Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp Gly 
225                 230                 235                 240 


Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile Arg 
                245                 250                 255     


Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln Glu 
            260                 265                 270         


Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys Ile 
        275                 280                 285             


Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln Lys 
    290                 295                 300                 


Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys Gln Asp Leu Thr Ser Phe 
305                 310                 315                 320 


Asn Met Glu Leu Ser Ser Ser Gly Ile Ser Ala Asp Leu Ser Arg Gly 
                325                 330                 335     


His Ala Val Val Gly Ala Val Gly Ala Lys Asp Trp Ala Gly Gly Phe 
            340                 345                 350         


Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp Thr Phe Ile Gly Asn Glu 
        355                 360                 365             


Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr Leu Gly Tyr Thr Val Thr 
    370                 375                 380                 


Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu Leu Ala Ser Gly Ala Pro 
385                 390                 395                 400 


Arg Tyr Gln His Met Gly Arg Val Leu Leu Phe Gln Glu Pro Gln Gly 
                405                 410                 415     


Gly Gly His Trp Ser Gln Val Gln Thr Ile His Gly Thr Gln Ile Gly 
            420                 425                 430         


Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val Asp Val Asp Gln Asp Gly 
        435                 440                 445             


Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro Leu Phe Tyr Gly Glu Gln 
    450                 455                 460                 


Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg Arg Gln Leu Gly Phe Glu 
465                 470                 475                 480 


Glu Val Ser Glu Leu Gln Gly Asp Pro Gly Tyr Pro Leu Gly Arg Phe 
                485                 490                 495     


Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile Asn Gly Asp Gly Leu Val 
            500                 505                 510         


Asp Val Ala Val Gly Ala Pro Leu Glu Glu Gln Gly Ala Val Tyr Ile 
        515                 520                 525             


Phe Asn Gly Arg His Gly Gly Leu Ser Pro Gln Pro Ser Gln Arg Ile 
    530                 535                 540                 


Glu Gly Thr Gln Val Leu Ser Gly Ile Gln Trp Phe Gly Arg Ser Ile 
545                 550                 555                 560 


His Gly Val Lys Asp Leu Glu Gly Asp Gly Leu Ala Asp Val Ala Val 
                565                 570                 575     


Gly Ala Glu Ser Gln Met Ile Val Leu Ser Ser Arg Pro Val Val Asp 
            580                 585                 590         


Met Val Thr Leu Met Ser Phe Ser Pro Ala Glu Ile Pro Val His Glu 
        595                 600                 605             


Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys Met Lys Glu Gly Val Asn 
    610                 615                 620                 


Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu Ile Pro Gln Phe Gln Gly 
625                 630                 635                 640 


Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu Gln Leu Asp Gly His Arg 
                645                 650                 655     


Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly Arg His Glu Leu Arg Arg 
            660                 665                 670         


Asn Ile Ala Val Thr Thr Ser Met Ser Cys Thr Asp Phe Ser Phe His 
        675                 680                 685             


Phe Pro Val Cys Val Gln Asp Leu Ile Ser Pro Ile Asn Val Ser Leu 
    690                 695                 700                 


Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr Pro Arg Asp Gln Arg Ala 
705                 710                 715                 720 


Gln Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro Ser Leu His Ser Glu 
                725                 730                 735     


Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly Glu Asp Lys Lys Cys 
            740                 745                 750         


Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala Arg Ser Arg Ala Leu 
        755                 760                 765             


Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu Leu Ser Leu Ser Asn 
    770                 775                 780                 


Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp Leu His Phe Pro Pro 
785                 790                 795                 800 


Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys Pro His Ser Gln Ile 
                805                 810                 815     


Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser Arg Leu Leu Ser Arg 
            820                 825                 830         


Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe Lys Ala Gly His Ser 
        835                 840                 845             


Val Ala Leu Gln Met Met Phe Asn Thr Leu Val Asn Ser Ser Trp Gly 
    850                 855                 860                 


Asp Ser Val Glu Leu His Ala Asn Val Thr Cys Asn Asn Glu Asp Ser 
865                 870                 875                 880 


Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile Ile Pro Ile Leu Tyr 
                885                 890                 895     


Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp Ser Thr Leu Tyr Val 
            900                 905                 910         


Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln Val Lys His Met Tyr 
        915                 920                 925             


Gln Val Arg Ile Gln Pro Ser Ile His Asp His Asn Ile Pro Thr Leu 
    930                 935                 940                 


Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser Glu Gly Pro Ile Thr 
945                 950                 955                 960 


His Gln Trp Ser Val Gln Met Glu Pro Pro Val Pro Cys His Tyr Glu 
                965                 970                 975     


Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly Ala 
            980                 985                 990         


Leu Phe Arg Cys Pro Val Val Phe  Arg Gln Glu Ile Leu  Val Gln Val 
        995                 1000                 1005             


Ile Gly  Thr Leu Glu Leu Val  Gly Glu Ile Glu Ala  Ser Ser Met 
    1010                 1015                 1020             


Phe Ser  Leu Cys Ser Ser Leu  Ser Ile Ser Phe Asn  Ser Ser Lys 
    1025                 1030                 1035             


His Phe  His Leu Tyr Gly Ser  Asn Ala Ser Leu Ala  Gln Val Val 
    1040                 1045                 1050             


Met Lys  Val Asp Val Val Tyr  Glu Lys Gln Met Leu  
    1055                 1060                 1065 


<210>  55
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFA-1beta Extracellular Domain (ECD)

<400>  55

Gln Glu Cys Thr Lys Phe Lys Val Ser Ser Cys Arg Glu Cys Ile Glu 
1               5                   10                  15      


Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys Leu Asn Phe Thr Gly Pro 
            20                  25                  30          


Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr Arg Pro Gln Leu Leu Met 
        35                  40                  45              


Arg Gly Cys Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala Glu 
    50                  55                  60                  


Thr Gln Glu Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln Lys 
65                  70                  75                  80  


Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val Thr 
                85                  90                  95      


Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp Leu Tyr Tyr Leu Met Asp 
            100                 105                 110         


Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg Asn Val Lys Lys Leu Gly 
        115                 120                 125             


Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile Thr Glu Ser Gly Arg Ile 
    130                 135                 140                 


Gly Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr 
145                 150                 155                 160 


His Pro Asp Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys 
                165                 170                 175     


Gln Pro Pro Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser 
            180                 185                 190         


Asn Gln Phe Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu 
        195                 200                 205             


Asp Ala Pro Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys 
    210                 215                 220                 


Pro Glu Glu Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala 
225                 230                 235                 240 


Thr Asp Asp Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile 
                245                 250                 255     


Leu Thr Pro Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys 
            260                 265                 270         


Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys 
        275                 280                 285             


Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met 
    290                 295                 300                 


Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val 
305                 310                 315                 320 


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Lys Asn 
                325                 330                 335     


Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu 
            340                 345                 350         


Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val 
        355                 360                 365             


Thr His Arg Asn Gln Pro Arg Gly Asp Cys Asp Gly Val Gln Ile Asn 
    370                 375                 380                 


Val Pro Ile Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln 
385                 390                 395                 400 


Glu Gln Ser Phe Val Ile Arg Ala Leu Gly Phe Thr Asp Ile Val Thr 
                405                 410                 415     


Val Gln Val Leu Pro Gln Cys Glu Cys Arg Cys Arg Asp Gln Ser Arg 
            420                 425                 430         


Asp Arg Ser Leu Cys His Gly Lys Gly Phe Leu Glu Cys Gly Ile Cys 
        435                 440                 445             


Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn Cys Glu Cys Gln Thr Gln 
    450                 455                 460                 


Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser Cys Arg Lys Asp Asn Asn 
465                 470                 475                 480 


Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys Val Cys Gly Gln Cys Leu 
                485                 490                 495     


Cys His Thr Ser Asp Val Pro Gly Lys Leu Ile Tyr Gly Gln Tyr Cys 
            500                 505                 510         


Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr Asn Gly Gln Val Cys Gly 
        515                 520                 525             


Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly Lys Cys Arg Cys His Pro 
    530                 535                 540                 


Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu Arg Thr Thr Glu Gly Cys 
545                 550                 555                 560 


Leu Asn Pro Arg Arg Val Glu Cys Ser Gly Arg Gly Arg Cys Arg Cys 
                565                 570                 575     


Asn Val Cys Glu Cys His Ser Gly Tyr Gln Leu Pro Leu Cys Gln Glu 
            580                 585                 590         


Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys Tyr Ile Ser Cys Ala Glu 
        595                 600                 605             


Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly Lys Asn Cys Ser Ala Ala 
    610                 615                 620                 


Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro Val Lys Gly Arg Thr Cys 
625                 630                 635                 640 


Lys Glu Arg Asp Ser Glu Gly Cys Trp Val Ala Tyr Thr Leu Glu Gln 
                645                 650                 655     


Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr Val Asp Glu Ser Arg Glu 
            660                 665                 670         


Cys Val Ala Gly Pro Asn 
        675             


<210>  56
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VCAM-1 Extracellular Domain (ECD)

<400>  56

Phe Lys Ile Glu Thr Thr Pro Glu Ser Arg Tyr Leu Ala Gln Ile Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Thr Cys Ser Thr Thr Gly Cys Glu Ser Pro Phe 
            20                  25                  30          


Phe Ser Trp Arg Thr Gln Ile Asp Ser Pro Leu Asn Gly Lys Val Thr 
        35                  40                  45              


Asn Glu Gly Thr Thr Ser Thr Leu Thr Met Asn Pro Val Ser Phe Gly 
    50                  55                  60                  


Asn Glu His Ser Tyr Leu Cys Thr Ala Thr Cys Glu Ser Arg Lys Leu 
65                  70                  75                  80  


Glu Lys Gly Ile Gln Val Glu Ile Tyr Ser Phe Pro Lys Asp Pro Glu 
                85                  90                  95      


Ile His Leu Ser Gly Pro Leu Glu Ala Gly Lys Pro Ile Thr Val Lys 
            100                 105                 110         


Cys Ser Val Ala Asp Val Tyr Pro Phe Asp Arg Leu Glu Ile Asp Leu 
        115                 120                 125             


Leu Lys Gly Asp His Leu Met Lys Ser Gln Glu Phe Leu Glu Asp Ala 
    130                 135                 140                 


Asp Arg Lys Ser Leu Glu Thr Lys Ser Leu Glu Val Thr Phe Thr Pro 
145                 150                 155                 160 


Val Ile Glu Asp Ile Gly Lys Val Leu Val Cys Arg Ala Lys Leu His 
                165                 170                 175     


Ile Asp Glu Met Asp Ser Val Pro Thr Val Arg Gln Ala Val Lys Glu 
            180                 185                 190         


Leu Gln Val Tyr Ile Ser Pro Lys Asn Thr Val Ile Ser Val Asn Pro 
        195                 200                 205             


Ser Thr Lys Leu Gln Glu Gly Gly Ser Val Thr Met Thr Cys Ser Ser 
    210                 215                 220                 


Glu Gly Leu Pro Ala Pro Glu Ile Phe Trp Ser Lys Lys Leu Asp Asn 
225                 230                 235                 240 


Gly Asn Leu Gln His Leu Ser Gly Asn Ala Thr Leu Thr Leu Ile Ala 
                245                 250                 255     


Met Arg Met Glu Asp Ser Gly Ile Tyr Val Cys Glu Gly Val Asn Leu 
            260                 265                 270         


Ile Gly Lys Asn Arg Lys Glu Val Glu Leu Ile Val Gln Glu Lys Pro 
        275                 280                 285             


Phe Thr Val Glu Ile Ser Pro Gly Pro Arg Ile Ala Ala Gln Ile Gly 
    290                 295                 300                 


Asp Ser Val Met Leu Thr Cys Ser Val Met Gly Cys Glu Ser Pro Ser 
305                 310                 315                 320 


Phe Ser Trp Arg Thr Gln Ile Asp Ser Pro Leu Ser Gly Lys Val Arg 
                325                 330                 335     


Ser Glu Gly Thr Asn Ser Thr Leu Thr Leu Ser Pro Val Ser Phe Glu 
            340                 345                 350         


Asn Glu His Ser Tyr Leu Cys Thr Val Thr Cys Gly His Lys Lys Leu 
        355                 360                 365             


Glu Lys Gly Ile Gln Val Glu Leu Tyr Ser Phe Pro Arg Asp Pro Glu 
    370                 375                 380                 


Ile Glu Met Ser Gly Gly Leu Val Asn Gly Ser Ser Val Thr Val Ser 
385                 390                 395                 400 


Cys Lys Val Pro Ser Val Tyr Pro Leu Asp Arg Leu Glu Ile Glu Leu 
                405                 410                 415     


Leu Lys Gly Glu Thr Ile Leu Glu Asn Ile Glu Phe Leu Glu Asp Thr 
            420                 425                 430         


Asp Met Lys Ser Leu Glu Asn Lys Ser Leu Glu Met Thr Phe Ile Pro 
        435                 440                 445             


Thr Ile Glu Asp Thr Gly Lys Ala Leu Val Cys Gln Ala Lys Leu His 
    450                 455                 460                 


Ile Asp Asp Met Glu Phe Glu Pro Lys Gln Arg Gln Ser Thr Gln Thr 
465                 470                 475                 480 


Leu Tyr Val Asn Val Ala Pro Arg Asp Thr Thr Val Leu Val Ser Pro 
                485                 490                 495     


Ser Ser Ile Leu Glu Glu Gly Ser Ser Val Asn Met Thr Cys Leu Ser 
            500                 505                 510         


Gln Gly Phe Pro Ala Pro Lys Ile Leu Trp Ser Arg Gln Leu Pro Asn 
        515                 520                 525             


Gly Glu Leu Gln Pro Leu Ser Glu Asn Ala Thr Leu Thr Leu Ile Ser 
    530                 535                 540                 


Thr Lys Met Glu Asp Ser Gly Val Tyr Leu Cys Glu Gly Ile Asn Gln 
545                 550                 555                 560 


Ala Gly Arg Ser Arg Lys Glu Val Glu Leu Ile Ile Gln Val Thr Pro 
                565                 570                 575     


Lys Asp Ile Lys Leu Thr Ala Phe Pro Ser Glu Ser Val Lys Glu Gly 
            580                 585                 590         


Asp Thr Val Ile Ile Ser Cys Thr Cys Gly Asn Val Pro Glu Thr Trp 
        595                 600                 605             


Ile Ile Leu Lys Lys Lys Ala Glu Thr Gly Asp Thr Val Leu Lys Ser 
    610                 615                 620                 


Ile Asp Gly Ala Tyr Thr Ile Arg Lys Ala Gln Leu Lys Asp Ala Gly 
625                 630                 635                 640 


Val Tyr Glu Cys Glu Ser Lys Asn Lys Val Gly Ser Gln Leu Arg Ser 
                645                 650                 655     


Leu Thr Leu Asp Val Gln Gly Arg Glu Asn Asn Lys Asp Tyr Phe Ser 
            660                 665                 670         


Pro Glu 
        


<210>  57
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-selectin Extracellular Domain (ECD)

<400>  57

Trp Thr Tyr His Tyr Ser Glu Lys Pro Met Asn Trp Gln Arg Ala Arg 
1               5                   10                  15      


Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile Gln Asn Lys 
            20                  25                  30          


Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu Pro Phe Ser Arg Ser Tyr 
        35                  40                  45              


Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly Ile Trp Thr Trp Val Gly 
    50                  55                  60                  


Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu Asn Trp Gly Asp Gly Glu 
65                  70                  75                  80  


Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys Val Glu Ile Tyr Ile Lys 
                85                  90                  95      


Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp Asp Ala Cys His Lys Leu 
            100                 105                 110         


Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys Gln Pro Trp Ser Cys Ser 
        115                 120                 125             


Gly His Gly Glu Cys Val Glu Ile Ile Asn Asn Tyr Thr Cys Asn Cys 
    130                 135                 140                 


Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln Phe Val Ile Gln Cys Glu 
145                 150                 155                 160 


Pro Leu Glu Ala Pro Glu Leu Gly Thr Met Asp Cys Thr His Pro Leu 
                165                 170                 175     


Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala Phe Ser Cys Ser Glu Gly 
            180                 185                 190         


Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr Cys Gly Pro Phe Gly Asn 
        195                 200                 205             


Trp Ser Ser Pro Glu Pro Thr Cys Gln Val Ile Gln Cys Glu Pro Leu 
    210                 215                 220                 


Ser Ala Pro Asp Leu Gly Ile Met Asn Cys Ser His Pro Leu Ala Ser 
225                 230                 235                 240 


Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile Cys Ser Glu Gly Thr Glu 
                245                 250                 255     


Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu Ser Ser Gly Ile Trp Ser 
            260                 265                 270         


Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp Lys Ser Phe Ser Met Ile 
        275                 280                 285             


Lys Glu Gly Asp Tyr Asn 
    290                 


<210>  58
<211>  943
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLA-4 Extracellular Domain (ECD)

<400>  58

Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His Asn Thr 
1               5                   10                  15      


Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn Arg Trp 
            20                  25                  30          


Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala Ser Val 
        35                  40                  45              


Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn Pro Gly 
    50                  55                  60                  


Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu Pro Cys 
65                  70                  75                  80  


Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly Val Thr 
                85                  90                  95      


Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys Gly His 
            100                 105                 110         


Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu Pro Thr 
        115                 120                 125             


Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu Ser Lys 
    130                 135                 140                 


Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly Glu Asn 
145                 150                 155                 160 


Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys Asp Leu 
                165                 170                 175     


Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser Leu Phe 
            180                 185                 190         


Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp Lys Gln 
        195                 200                 205             


Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly Ala Gly 
    210                 215                 220                 


His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala Pro Gln 
225                 230                 235                 240 


His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu Lys Glu 
                245                 250                 255     


Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser Tyr Phe 
            260                 265                 270         


Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe Ser Asp 
        275                 280                 285             


Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu Gly Arg 
    290                 295                 300                 


Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn Ala Met 
305                 310                 315                 320 


Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe Gly Glu 
                325                 330                 335     


Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu Asp Val 
            340                 345                 350         


Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile Tyr Ile 
        355                 360                 365             


Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln Arg Ile 
    370                 375                 380                 


Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln Ser Ile 
385                 390                 395                 400 


Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val Ala Val 
                405                 410                 415     


Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg Pro Val 
            420                 425                 430         


Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn Arg Thr 
        435                 440                 445             


Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile Asp Leu 
    450                 455                 460                 


Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr Ile Val 
465                 470                 475                 480 


Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu Ser Pro 
                485                 490                 495     


Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile Thr Gly 
            500                 505                 510         


Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His Gln Ala 
        515                 520                 525             


Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln Ile Glu 
    530                 535                 540                 


Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser Thr Glu 
545                 550                 555                 560 


Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu Lys Asp 
                565                 570                 575     


Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His Glu Asn 
            580                 585                 590         


Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu Lys Pro 
        595                 600                 605             


His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr Leu Met 
    610                 615                 620                 


Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu Thr Thr 
625                 630                 635                 640 


Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile Leu Glu 
                645                 650                 655     


Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser Gly Val 
            660                 665                 670         


Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His Leu Ser 
        675                 680                 685             


Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser Arg Ala 
    690                 695                 700                 


Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn Glu Glu 
705                 710                 715                 720 


Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile Pro Leu 
                725                 730                 735     


Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro Thr Ser 
            740                 745                 750         


Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys Met Val 
        755                 760                 765             


Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn Ser Met 
    770                 775                 780                 


Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe Ser Pro 
785                 790                 795                 800 


Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr Thr Gly 
                805                 810                 815     


Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu Gln Gln 
            820                 825                 830         


Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu Ser Lys 
        835                 840                 845             


Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His Cys Leu 
    850                 855                 860                 


Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu Ala Ser 
865                 870                 875                 880 


Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met Asp Glu 
                885                 890                 895     


Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro Glu Pro 
            900                 905                 910         


Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala His Val 
        915                 920                 925             


Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe Thr 
    930                 935                 940             


<210>  59
<211>  127
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  MISC_FEATURE
<223>  Minimal streptavidin

<400>  59

Met Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr 
1               5                   10                  15      


Phe Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu 
            20                  25                  30          


Ser Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr 
        35                  40                  45              


Asp Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr 
    50                  55                  60                  


Val Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp 
65                  70                  75                  80  


Ser Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp 
                85                  90                  95      


Leu Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu 
            100                 105                 110         


Val Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125         


<210>  60
<211>  127
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  MISC_FEATURE
<223>  Mutein Streptavidin Val44-Thr45-Ala46-Arg47

<400>  60

Met Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr 
1               5                   10                  15      


Phe Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val 
            20                  25                  30          


Thr Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr 
        35                  40                  45              


Asp Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr 
    50                  55                  60                  


Val Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp 
65                  70                  75                  80  


Ser Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp 
                85                  90                  95      


Leu Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu 
            100                 105                 110         


Val Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125         


<210>  61
<211>  126
<212>  PRT
<213>  Streptomyces avidinii


<220>
<221>  MISC_FEATURE
<223>  Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47

<400>  61

Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
1               5                   10                  15      


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Ile Gly 
            20                  25                  30          


Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
        35                  40                  45              


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
    50                  55                  60                  


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
65                  70                  75                  80  


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
                85                  90                  95      


Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val 
            100                 105                 110         


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser 
        115                 120                 125     


