                         SEQUENCE LISTING

<110>  University of Newcastle Upon Tyne
 
<120>  Serum-Stabilised Mini Factor H

<130>  P031134WO

<150>  GB1707248.9
<151>  2017-05-05

<150>  GB1706808.1
<151>  2017-04-28

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  1213
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         


Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             


Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 


Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 


Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     


Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         


Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             


Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 


Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 


Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     


Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         


Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             


Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 


Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 


Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     


Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         


Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             


Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 


Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 


Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     


Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         


Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             


Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 


Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 


Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     


Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         


Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             


Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 


Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     


Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         


Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             


Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 


Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 


Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     


Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         


Gly Glu Gln Val Thr Tyr Thr Cys  Ala Thr Tyr Tyr Lys  Met Asp Gly 
        995                 1000                 1005             


Ala Ser  Asn Val Thr Cys Ile  Asn Ser Arg Trp Thr  Gly Arg Pro 
    1010                 1015                 1020             


Thr Cys  Arg Asp Thr Ser Cys  Val Asn Pro Pro Thr  Val Gln Asn 
    1025                 1030                 1035             


Ala Tyr  Ile Val Ser Arg Gln  Met Ser Lys Tyr Pro  Ser Gly Glu 
    1040                 1045                 1050             


Arg Val  Arg Tyr Gln Cys Arg  Ser Pro Tyr Glu Met  Phe Gly Asp 
    1055                 1060                 1065             


Glu Glu  Val Met Cys Leu Asn  Gly Asn Trp Thr Glu  Pro Pro Gln 
    1070                 1075                 1080             


Cys Lys  Asp Ser Thr Gly Lys  Cys Gly Pro Pro Pro  Pro Ile Asp 
    1085                 1090                 1095             


Asn Gly  Asp Ile Thr Ser Phe  Pro Leu Ser Val Tyr  Ala Pro Ala 
    1100                 1105                 1110             


Ser Ser  Val Glu Tyr Gln Cys  Gln Asn Leu Tyr Gln  Leu Glu Gly 
    1115                 1120                 1125             


Asn Lys  Arg Ile Thr Cys Arg  Asn Gly Gln Trp Ser  Glu Pro Pro 
    1130                 1135                 1140             


Lys Cys  Leu His Pro Cys Val  Ile Ser Arg Glu Ile  Met Glu Asn 
    1145                 1150                 1155             


Tyr Asn  Ile Ala Leu Arg Trp  Thr Ala Lys Gln Lys  Leu Tyr Ser 
    1160                 1165                 1170             


Arg Thr  Gly Glu Ser Val Glu  Phe Val Cys Lys Arg  Gly Tyr Arg 
    1175                 1180                 1185             


Leu Ser  Ser Arg Ser His Thr  Leu Arg Thr Thr Cys  Trp Asp Gly 
    1190                 1195                 1200             


Lys Leu  Glu Tyr Pro Thr Cys  Ala Lys Arg 
    1205                 1210             


<210>  2
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe Leu Tyr 
1               5                   10                  15      


Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly Glu Val 
            20                  25                  30          


Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe 
        35                  40                  45              


Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys 
    50                  55                  60                  


Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His Ser Glu 
65                  70                  75                  80  


Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys 
                85                  90                  95      


Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser Cys Val 
            100                 105                 110         


Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys Gly Glu 
        115                 120                 125             


Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro Lys Lys 
    130                 135                 140                 


Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg Lys Asn 
145                 150                 155                 160 


Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe Gly Trp 
                165                 170                 175     


Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys Gly Pro 
            180                 185                 190         


Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys Glu Glu 
        195                 200                 205             


Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn Phe Ile 
    210                 215                 220                 


Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp Thr Thr 
225                 230                 235                 240 


Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile Pro Glu 
                245                 250                 255     


Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln His Gly 
            260                 265                 270         


Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile Gly Asn 
        275                 280                 285             


Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro Met Cys 
    290                 295                 300                 


Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val Asn Ile 
305                 310                 315                 320 


Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn Ser Arg 
                325                 330                 335     


Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser Val Cys 
            340                 345                 350         


Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys Arg Glu 
        355                 360                 365             


Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn Met Thr 
    370                 375                 380                 


Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu Cys Lys 
385                 390                 395                 400 


Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys Asp Gly 
                405                 410                 415     


Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr Cys Gly 
            420                 425                 430         


Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro Leu Ser 
        435                 440                 445             


Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser Phe Tyr 
    450                 455                 460                 


Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln Trp Ser 
465                 470                 475                 480 


Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu Asn Met 
                485                 490                 495     


Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys Leu Tyr 
            500                 505                 510         


Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro His Lys 
        515                 520                 525             


Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu Gly Lys 
    530                 535                 540                 


Phe Glu Tyr Pro Ile Cys Glu 
545                 550     


<210>  3
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr Leu 
            420                 425                 430     


<210>  4
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr 
1               5                   10                  15      


Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val 
            20                  25                  30          


Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe 
        35                  40                  45              


Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys 
    50                  55                  60                  


Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu 
65                  70                  75                  80  


Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys 
                85                  90                  95      


Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val 
            100                 105                 110         


Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp Thr Ser 
        115                 120                 125             


Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser Arg Gln 
    130                 135                 140                 


Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys Arg Ser 
145                 150                 155                 160 


Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn 
                165                 170                 175     


Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro 
            180                 185                 190         


Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val 
        195                 200                 205             


Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 
    210                 215                 220                 


Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu 
225                 230                 235                 240 


Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu 
                245                 250                 255     


Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Leu 
            260                 265                 270         


Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu 
        275                 280                 285             


Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu 
    290                 295                 300                 


Glu Tyr Pro Thr Cys Ala Lys Arg 
305                 310         


<210>  5
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  6
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
                565                 


<210>  7
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  8
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  9
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


<210>  10
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
1               5                   10                  15      


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
            20                  25                  30          


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
        35                  40                  45              


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val 
    50                  55                  60      


<210>  11
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser 
1               5                   10                  15      


Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg 
            20                  25                  30          


Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His 
        35                  40                  45              


Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu 
    50                  55                  60                  


<210>  12
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln 
1               5                   10                  15      


Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met 
            20                  25                  30          


Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly 
        35                  40                  45              


Trp Arg Pro Leu Pro Ser Cys Glu Glu 
    50                  55          


<210>  13
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu 
1               5                   10                  15      


Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn 
            20                  25                  30          


Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr 
        35                  40                  45              


Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    50                  55              


<210>  14
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
1               5                   10                  15      


Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
            20                  25                  30          


Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
        35                  40                  45              


Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
    50                  55                  60              


<210>  15
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
1               5                   10                  15      


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
            20                  25                  30          


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
        35                  40                  45              


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg 
    50                  55              


<210>  16
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser 
1               5                   10                  15      


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys 
            20                  25                  30          


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
        35                  40                  45              


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr 
    50                  55                  60      


<210>  17
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser 
1               5                   10                  15      


Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys 
            20                  25                  30          


Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn 
        35                  40                  45              


Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
    50                  55                  60              


<210>  18
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
1               5                   10                  15      


Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
            20                  25                  30          


Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
        35                  40                  45              


Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
    50                  55                  60          


<210>  19
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn Met Thr 
1               5                   10                  15      


Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu Cys Lys 
            20                  25                  30          


Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys Asp Gly 
        35                  40                  45              


Arg Trp Gln Ser Leu Pro Arg Cys Val Glu 
    50                  55              


<210>  20
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Tyr Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser 
1               5                   10                  15      


Phe Pro Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys 
            20                  25                  30          


Gln Ser Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn 
        35                  40                  45              


Lys Gln Trp Ser Glu Pro Pro Arg Cys Leu Asp 
    50                  55                  


<210>  21
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Val Val Ser Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys 
1               5                   10                  15      


Trp Arg Asn Asp Gly Lys Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu 
            20                  25                  30          


Phe Gln Cys Lys Phe Pro His Lys Ala Met Ile Ser Ser Pro Pro Phe 
        35                  40                  45              


Arg Ala Ile Cys Gln Glu Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
    50                  55                  60              


<210>  22
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  22

Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
1               5                   10                  15      


Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
            20                  25                  30          


Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
        35                  40                  45              


Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
    50                  55                  60              


<210>  23
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
1               5                   10                  15      


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
            20                  25                  30          


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
        35                  40                  45              


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr Leu 
    50                  55                  60              


<210>  24
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr 
1               5                   10                  15      


Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val 
            20                  25                  30          


Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe 
        35                  40                  45              


Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys 
    50                  55                  60                  


Cys Leu 
65      


<210>  25
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu Ser Ser 
1               5                   10                  15      


Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys Asn Thr 
            20                  25                  30          


Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val Glu Arg 
        35                  40                  45              


Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp Thr Ser 
    50                  55                  60          


<210>  26
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Ser 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Val Asp Thr Thr Ser Cys Val Asn Pro Pro 
305                 310                 315                 320 


Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 
                325                 330                 335     


Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe 
            340                 345                 350         


Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro 
        355                 360                 365             


Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp 
    370                 375                 380                 


Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser 
385                 390                 395                 400 


Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys 
                405                 410                 415     


Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu 
            420                 425                 430         


His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala 
        435                 440                 445             


Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser 
    450                 455                 460                 


Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His 
465                 470                 475                 480 


Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys 
                485                 490                 495     


Ala Lys Arg Gly Thr Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn 
            500                 505                 510         


His Gly Ile Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val 
        515                 520                 525             


Pro Thr Gly Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser 
    530                 535                 540                 


Pro Ser Lys Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp 
545                 550                 555                 560 


Ser Pro Thr Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu 
                565                 570                 575     


Asn Gly His Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr 
            580                 585                 590         


Val Gln Ile Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn 
        595                 600                 605             


Asn Ile Ser Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg 
    610                 615                 620                 


Ser Thr Asp Thr Ser 
625                 


<210>  27
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr 
1               5                   10                  15      


Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val 
            20                  25                  30          


Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe 
        35                  40                  45              


Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys 
    50                  55                  60                  


Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu 
65                  70                  75                  80  


Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys 
                85                  90                  95      


Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val 
            100                 105                 110         


Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp Thr Ser 
        115                 120                 125             


Val Asp Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
    130                 135                 140                 


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
145                 150                 155                 160 


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
                165                 170                 175     


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
            180                 185                 190         


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
        195                 200                 205             


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
    210                 215                 220                 


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
225                 230                 235                 240 


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
                245                 250                 255     


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
            260                 265                 270         


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
        275                 280                 285             


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
    290                 295                 300                 


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
305                 310                 315                 320 


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
                325                 330                 335     


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
            340                 345                 350         


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
        355                 360                 365             


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
    370                 375                 380                 


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
385                 390                 395                 400 


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
                405                 410                 415     


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
            420                 425                 430         


Thr Ser Gly Ser Gly Gly Gly Gly Gly Thr Thr Ser Cys Val Asn Pro 
        435                 440                 445             


Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr 
    450                 455                 460                 


Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met 
465                 470                 475                 480 


Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro 
                485                 490                 495     


Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile 
            500                 505                 510         


Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala 
        515                 520                 525             


Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn 
    530                 535                 540                 


Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys 
545                 550                 555                 560 


Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile 
                565                 570                 575     


Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu 
            580                 585                 590         


Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser 
        595                 600                 605             


His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr 
    610                 615                 620                 


Cys Ala Lys Arg 
625             


<210>  28
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Ser 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Val Asp Thr Lys His Gly Gly Leu Tyr His 
305                 310                 315                 320 


Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr 
                325                 330                 335     


Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp 
            340                 345                 350         


Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys 
        355                 360                 365             


Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn 
    370                 375                 380                 


Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His 
385                 390                 395                 400 


Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu 
                405                 410                 415     


Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr Leu 
            420                 425                 430         


Gly Thr Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
        435                 440                 445             


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
    450                 455                 460                 


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
465                 470                 475                 480 


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
                485                 490                 495     


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
            500                 505                 510         


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
        515                 520                 525             


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
    530                 535                 540                 


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
545                 550                 555                 560 


Thr Ser 
        


<210>  29
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr 
1               5                   10                  15      


Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val 
            20                  25                  30          


Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe 
        35                  40                  45              


Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys 
    50                  55                  60                  


Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu 
65                  70                  75                  80  


Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys 
                85                  90                  95      


Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val 
            100                 105                 110         


Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp Thr Ser 
        115                 120                 125             


Val Asp Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
    130                 135                 140                 


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
145                 150                 155                 160 


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
                165                 170                 175     


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
            180                 185                 190         


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
        195                 200                 205             


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
    210                 215                 220                 


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
225                 230                 235                 240 


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
                245                 250                 255     


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
            260                 265                 270         


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
        275                 280                 285             


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
    290                 295                 300                 


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
305                 310                 315                 320 


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
                325                 330                 335     


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
            340                 345                 350         


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
        355                 360                 365             


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
    370                 375                 380                 


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
385                 390                 395                 400 


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
                405                 410                 415     


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
            420                 425                 430         


Thr Ser Gly Ser Gly Gly Gly Gly Gly Thr Lys His Gly Gly Leu Tyr 
        435                 440                 445             


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
    450                 455                 460                 


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
465                 470                 475                 480 


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
                485                 490                 495     


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
            500                 505                 510         


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
        515                 520                 525             


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
    530                 535                 540                 


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
545                 550                 555                 560 


Leu 
    


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Gly Ser Gly Gly Gly Gly 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Gly Ser Gly Gly Gly Gly Gly Thr 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Gly Ser Gly Gly Gly Gly Val Asp 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Gly Ser Gly Gly Gly Gly Val Asp Thr 
1               5                   10  


<210>  34
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  34
gctctagaat gtggctcctg gtcagtgta                                         29


<210>  35
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  35
cgcgtcgacg gaagtgtcag tggacctgc                                         29


<210>  36
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  36
cgcgtcgacg aagattgcaa tgaacttcct cc                                     32


<210>  37
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  37
ggggtacccc cacctcctcc cgaac                                             25


<210>  38
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  38
gctctagaat gtggctcctg gtc                                               23


<210>  39
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  39
ggggtacccc cacctcc                                                      17


<210>  40
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  40
ggggtaccga agcaacattt tgtgattttc ca                                     32


<210>  41
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  41
ctagctagct taggaagtgt cagtggacct gc                                     32


<210>  42
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  42
cgcgtcgaca ccacctcctc atgtgtgaat                                        30


<210>  43
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  43
ggggtacctc tttttgcaca agttggatac tc                                     32


<210>  44
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  44
cgcgtcgaca ccacctc                                                      17


<210>  45
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  45
ctagctagct taggaagtgt cagtggacc                                         29


<210>  46
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Ser Gly Ser Gly Gly Gly Gly Val Asp Thr Thr Ser Cys Val Asn 
                325                 330                 335     


Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys 
            340                 345                 350         


Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu 
        355                 360                 365             


Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 
    370                 375                 380                 


Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro 
385                 390                 395                 400 


Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
                405                 410                 415     


Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
            420                 425                 430         


Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
        435                 440                 445             


Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
    450                 455                 460                 


Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
465                 470                 475                 480 


Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
                485                 490                 495     


Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
            500                 505                 510         


Thr Cys Ala Lys Arg Gly Thr Glu Ala Thr Phe Cys Asp Phe Pro Lys 
        515                 520                 525             


Ile Asn His Gly Ile Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser 
    530                 535                 540                 


Gln Val Pro Thr Gly Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe 
545                 550                 555                 560 


Val Ser Pro Ser Lys Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu 
                565                 570                 575     


Gly Trp Ser Pro Thr Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe 
            580                 585                 590         


Val Glu Asn Gly His Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly 
        595                 600                 605             


Asp Thr Val Gln Ile Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn 
    610                 615                 620                 


Glu Asn Asn Ile Ser Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys 
625                 630                 635                 640 


Cys Arg Ser Thr Asp Thr Ser 
                645         


<210>  47
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Val Asp Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr 
145                 150                 155                 160 


Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr 
                165                 170                 175     


Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile 
            180                 185                 190         


Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg 
        195                 200                 205             


Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly 
    210                 215                 220                 


Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala 
225                 230                 235                 240 


Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr 
                245                 250                 255     


Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu 
            260                 265                 270         


Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val 
        275                 280                 285             


Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val 
    290                 295                 300                 


Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met 
305                 310                 315                 320 


His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val 
                325                 330                 335     


Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser 
            340                 345                 350         


Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn 
        355                 360                 365             


Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser 
    370                 375                 380                 


Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro 
385                 390                 395                 400 


Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr 
                405                 410                 415     


Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr 
            420                 425                 430         


Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro 
        435                 440                 445             


Arg Cys Thr Ser Gly Ser Gly Gly Gly Gly Gly Thr Thr Ser Cys Val 
    450                 455                 460                 


Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser 
465                 470                 475                 480 


Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr 
                485                 490                 495     


Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr 
            500                 505                 510         


Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 
        515                 520                 525             


Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala 
    530                 535                 540                 


Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
545                 550                 555                 560 


Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro 
                565                 570                 575     


Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr 
            580                 585                 590         


Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr 
        595                 600                 605             


Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser 
    610                 615                 620                 


Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr 
625                 630                 635                 640 


Pro Thr Cys Ala Lys Arg 
                645     


<210>  48
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Ser Gly Ser Gly Gly Gly Gly Val Asp Thr Lys His Gly Gly Leu 
                325                 330                 335     


Tyr His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys 
            340                 345                 350         


Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser 
        355                 360                 365             


Tyr Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val 
    370                 375                 380                 


Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn 
385                 390                 395                 400 


Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala 
                405                 410                 415     


Cys His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys 
            420                 425                 430         


Met Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe 
        435                 440                 445             


Thr Leu Gly Thr Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His 
    450                 455                 460                 


Gly Ile Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro 
465                 470                 475                 480 


Thr Gly Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro 
                485                 490                 495     


Ser Lys Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser 
            500                 505                 510         


Pro Thr Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn 
        515                 520                 525             


Gly His Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val 
    530                 535                 540                 


Gln Ile Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn 
545                 550                 555                 560 


Ile Ser Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser 
                565                 570                 575     


Thr Asp Thr Ser 
            580 


<210>  49
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Val Asp Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr 
145                 150                 155                 160 


Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr 
                165                 170                 175     


Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile 
            180                 185                 190         


Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg 
        195                 200                 205             


Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly 
    210                 215                 220                 


Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala 
225                 230                 235                 240 


Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr 
                245                 250                 255     


Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu 
            260                 265                 270         


Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val 
        275                 280                 285             


Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val 
    290                 295                 300                 


Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met 
305                 310                 315                 320 


His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val 
                325                 330                 335     


Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser 
            340                 345                 350         


Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn 
        355                 360                 365             


Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser 
    370                 375                 380                 


Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro 
385                 390                 395                 400 


Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr 
                405                 410                 415     


Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr 
            420                 425                 430         


Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro 
        435                 440                 445             


Arg Cys Thr Ser Gly Ser Gly Gly Gly Gly Gly Thr Lys His Gly Gly 
    450                 455                 460                 


Leu Tyr His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
465                 470                 475                 480 


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
                485                 490                 495     


Ser Tyr Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala 
            500                 505                 510         


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
        515                 520                 525             


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val 
    530                 535                 540                 


Ala Cys His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr 
545                 550                 555                 560 


Cys Met Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser 
                565                 570                 575     


Phe Thr Leu 
            


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence H6GT

<400>  50

His His His His His His Gly Thr 
1               5               


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence SGSG4GT

<400>  51

Ser Gly Ser Gly Gly Gly Gly Gly Thr 
1               5                   


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SGSG4VDT

<400>  52

Ser Gly Ser Gly Gly Gly Gly Val Asp Thr 
1               5                   10  


<210>  53
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  53
ggggtaccac cttgaaacct tgtgattatc c                                      31


<210>  54
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  54
ctagctagct cagagggtaa agctgacacg                                        30


<210>  55
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  55
acgcgtcgac accttgaaac cttgtgatta tcc                                    33


<210>  56
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  56
ggggtaccga gggtaaagct gacacggat                                         29


