                         SEQUENCE LISTING

<110>  Amgen Inc
 
<120>  TREM2 ANTIGEN BINDING PROTEINS AND USES THEREOF

<130>  A-2129-WO-PCT

<140>  PCT/US XX/XXXXXX
<141>  2018-04-18

<150>  62/488,691
<151>  2017-04-21

<150>  62/530,753
<151>  2017-07-10

<150>  62/580,400
<151>  2017-11-01

<160>  367   

<170>  PatentIn version 3.5

<210>  1
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210>  2
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser 
                165                 170                 


<210>  3
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  4
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRDL1 Antibody ID 12G10

<400>  5

Thr Leu Arg Ser Gly Ile Asn Val Gly Thr Tyr Arg Ile Tyr 
1               5                   10                  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 26C10

<400>  6

Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val Cys 
1               5                   10      


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 24C12

<400>  7

Lys Ser Ser Arg Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 24G6

<400>  8

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys His Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 24A10

<400>  9

Lys Ser Ser His Asn Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 10E3

<400>  10

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 25F12

<400>  11

Arg Ala Ser Gln Ser Val Asn Asn Asn Leu Ala 
1               5                   10      


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 32E3

<400>  12

Arg Ala Ser Gln Ile Ile Ser Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 24F4

<400>  13

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 16B8

<400>  14

Arg Ala Ser Gln Asp Ile Asn Ser Trp Leu Ala 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 4C5

<400>  15

Arg Ala Ser Gln Gly Ile Ser Asn Trp Leu Ala 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 6E7

<400>  16

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 5E3

<400>  17

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID 4G10

<400>  18

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 12G10

<400>  19

Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 26C10

<400>  20

Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 26C10

<400>  21

Gln Asp Thr Lys Arg Pro Ser 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 24C12

<400>  22

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 10E3

<400>  23

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 32E3

<400>  24

Ser Ala Ser Ser Arg Ala Thr 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 24F4

<400>  25

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 16B8

<400>  26

Ala Ala Ser Ser Leu Gln Thr 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 4C5

<400>  27

Ala Ala Ser Ser Leu Gln Val 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 6E7

<400>  28

Ala Ala Ser Ser Leu Gln Asn 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 5E3

<400>  29

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID 4G10

<400>  30

Ala Ala Ser Ser Leu Pro Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 12G10

<400>  31

Met Ile Trp Tyr Ser Ser Ala Val Val 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 26A10

<400>  32

Gln Ala Trp Asp Ser Asn Thr Val Val 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 26C10

<400>  33

Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 24C12

<400>  34

Gln Gln Tyr Tyr Ile Thr Pro Ile Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 24G6

<400>  35

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody 24A10

<400>  36

His Gln Tyr Tyr Ser Thr Pro Cys Ser 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 10E3

<400>  37

Leu Gln Asp Asn Asn Trp Pro Pro Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 25F12

<400>  38

Gln Gln Tyr Asn Asn Trp Pro Arg Thr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 32E3

<400>  39

Gln Gln Phe Asp Ser Ser Pro Ile Thr 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 24F4

<400>  40

Gln Gln Tyr Asp Thr Ser Pro Phe Thr 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 16B8

<400>  41

Gln Gln Ser Asn Ser Phe Pro Ile Thr 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 4C5

<400>  42

Gln Gln Ala Asp Ser Phe Pro Arg Asn 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 6E7

<400>  43

Gln Gln Ala Asp Ser Phe Pro Arg Thr 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 5E3

<400>  44

Gln Gln Tyr Ser Thr Tyr Pro Phe Thr 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID 4G10

<400>  45

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  46
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 12G10

<400>  46

Gln Ala Val Pro Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Val 
1               5                   10                  15      


Leu Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Thr 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp Tyr Ser Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  47
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 26A10

<400>  47

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Asn Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  48
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 26C10

<400>  48

Ser Phe Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Met Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  49
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 26F2

<400>  49

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Phe 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  50
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 33B12

<400>  50

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  51
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antobody ID 24C12

<400>  51

Gly Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Arg Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Asn Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ile Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  52
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 24G6

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys His Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Phe Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  53
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 24A10

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Thr Cys Lys Ser Ser His Asn Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Cys Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  54
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 10E3

<400>  54

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Val 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Phe Tyr Tyr Cys Leu Gln Asp Asn Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 13E7 14C12

<400>  55

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Val 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Asp Asn Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 25F12

<400>  56

Glu Lys Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 25F12

<400>  57

Glu Phe Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Arg Gly Thr Arg Leu Asp Ile Lys 
            100                 105             


<210>  58
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 24F4

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Asp Thr Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 16B8

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asp Ile Asn Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 4C5

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Val Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Asn Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 6E7

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID 5E3

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Anti-Human TREM2 Antibody Light Chain Variable Region 
       Amino Acid Sequences - VL Amino Acid Sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Pro Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Thr 
            100                 105         


<210>  64
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  65
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  66
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  67
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  70
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  71
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  73
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  74
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  75
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  75

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Thr 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ser Val Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu 
        115     


<210>  76
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  76

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Anti-Human TREM2 Antibody Heavy Chain Variable Region 
       Amino Acid Sequences - CDRH1

<400>  77

Ser Tyr Ala Met Ser 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 26A10

<400>  78

Ser Phe Gly Met Ser 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 24A10

<400>  79

Asn Tyr Ala Met Ser 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 10E3

<400>  80

Asn Tyr Trp Ile Gly 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 13E7 14C12

<400>  81

Ser Tyr Trp Ile Gly 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 25F12

<400>  82

Ser Tyr Tyr Trp Ser 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody 16B8

<400>  83

Asn Tyr Gly Ile Ser 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 4C5

<400>  84

Asn Tyr Trp Ile Ala 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 6E7

<400>  85

Ser Tyr Trp Ile Ala 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID 5E3

<400>  86

Gly Tyr Tyr Ile His 
1               5   


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID 12G10 24C12

<400>  87

Ala Ile Gly Gly Gly Gly Val Ser Thr Tyr Cys Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Anti-Human TREM2 Antibody Heavy Chain Variable Region 
       Amino Acid Sequences - CDRH2

<400>  88

Tyr Ile Ser Ser Ser Ser Phe Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibidy 26A10

<400>  89

Tyr Ile Ser Lys Ser Ser Phe Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID24G6

<400>  90

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID 10E3

<400>  91

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID 25F12

<400>  92

Glu Ile Asn His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID 16B8

<400>  93

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody 4C5

<400>  94

Trp Ile Asn Pro Tyr Ser Gly Gly Thr Thr Ser Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody 12G10 24C12

<400>  95

Phe Tyr Ile Ala Val Ala Gly Ser His Phe Asp Tyr 
1               5                   10          


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 26A10

<400>  96

Glu Gly Gly Leu Thr Met Val Arg Gly Val Ser Ser Tyr Gly Leu Asp 
1               5                   10                  15      


Val 
    


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 26C10

<400>  97

Glu Gly Gly Ile Thr Met Val Arg Gly Val Ser Ser Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 24G6

<400>  98

Ala Tyr Thr Pro Met Ala Phe Phe Asp Tyr 
1               5                   10  


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 24A10

<400>  99

Gly Gly Trp Glu Leu Phe Tyr 
1               5           


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 10E3

<400>  100

Arg Arg Gln Gly Ile Trp Gly Asp Ala Leu Asp Ile 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 13E7 14C12

<400>  101

Arg Arg Gln Gly Ile Trp Gly Asp Ala Leu Asp Phe 
1               5                   10          


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 25F12

<400>  102

Glu Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr His Asp Ala Phe Asp Ile 
1               5                   10                  15      


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 32E3

<400>  103

His Asp Ile Ile Pro Ala Ala Pro Gly Ala Phe Asp Ile 
1               5                   10              


<210>  104
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 24F4

<400>  104

Gln Ala Ile Ala Val Thr Gly Leu Gly Gly Phe Asp Pro 
1               5                   10              


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 16B8

<400>  105

Arg Gly Tyr Ser Tyr Gly Ser Phe Asp Tyr 
1               5                   10  


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 4C5

<400>  106

Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210>  107
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 6E7

<400>  107

Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  108
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 5E3

<400>  108

Asp Gly Gly Tyr Leu Ala Leu Tyr Gly Thr Asp Val 
1               5                   10          


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID 4G10

<400>  109

Gln Gly Ile Glu Val Thr Gly Thr Gly Gly Leu Asp Val 
1               5                   10              


<210>  110
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 12G10 24C12

<400>  110

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Gly Gly Gly Val Ser Thr Tyr Cys Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Phe Tyr Ile Ala Val Ala Gly Ser His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  111
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 26A10

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Arg Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Phe Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Leu Thr Met Val Arg Gly Val Ser Ser Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  112
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 26C10

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Phe Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Glu Gly Gly Ile Thr Met Val Arg Gly Val Ser Ser Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  113
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 26F2

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Phe Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Ile Thr Met Val Arg Gly Val Ser Ser Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  114
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 33B12

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Lys Ser Ser Phe Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Leu Thr Met Val Arg Gly Val Ser Ser Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  115
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 24G6

<400>  115

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Tyr Thr Pro Met Ala Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  116
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 24A10

<400>  116

Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Trp Glu Leu Phe Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  117
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 10E3

<400>  117

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Met Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Arg Gln Gly Ile Trp Gly Asp Ala Leu Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  118
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 13E7 14C12

<400>  118

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Met Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Arg Gln Gly Ile Trp Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  119
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 25F12

<400>  119

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Asp Gln Gly Thr Met Val Thr Val Phe Ser 
        115                 120                 


<210>  120
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 32E3

<400>  120

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Thr Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Ile Ile Pro Ala Ala Pro Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  121
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 24F4

<400>  121

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Ala Ile Ala Val Thr Gly Leu Gly Gly Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  122
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 16B8

<400>  122

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Ser Tyr Gly Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  123
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 4C5

<400>  123

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly His Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  124
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 6E7

<400>  124

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  125
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 5E3

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Ser Gly Gly Thr Thr Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Leu Ala Leu Tyr Gly Thr Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  126
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID 4G10

<400>  126

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Pro Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Lys Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Gly Ile Glu Val Thr Gly Thr Gly Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  127
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Tyr Asp Tyr Val Trp Gly Ser Tyr Arg Tyr Thr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  128
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  129
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  129

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Tyr Cys Gly Gly Asp Cys Tyr Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  130
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  130

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Thr Gly Thr Ala Glu Tyr Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  131
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  131

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Gly Thr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  132
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  132

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asn Trp Asn Asp Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  133
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  133

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Ile Val Ala Thr Ile Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  134
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  134

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Ile Val Ala Thr Ile Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  135
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Gly Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  136
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  136

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Gly Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  138
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  138

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Ile Val Ala Thr Ile Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Consensus for 6E7 improved Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is L or R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is N, K, R, L, or T

<400>  139

Xaa Ala Ser Ser Xaa Gln Xaa 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Consensus for 6E7 improved Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Q or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is F, L or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is R or H

<400>  140

Xaa Gln Ala Asp Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  141
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Consensus for 6E7 improved Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is T or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is Y or L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is S, G, or E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is G or D

<400>  141

Xaa Ile Tyr Pro Gly Asp Ser Asp Xaa Arg Xaa Xaa Pro Xaa Phe Gln 
1               5                   10                  15      


Xaa 
    


<210>  142
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Consensus for 6E7 improved Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Q, G, S, or M

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is F or S

<400>  142

Xaa Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Xaa Asp Tyr 
1               5                   10                  


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V3

<400>  143

Ala Ala Ser Ser Arg Gln Asn 
1               5           


<210>  144
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V24 C01

<400>  144

Ala Ala Ser Ser Leu Gln Lys 
1               5           


<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V27 C04

<400>  145

Ala Ala Ser Ser Leu Gln Arg 
1               5           


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Anitbody ID V40 D05

<400>  146

Ala Ala Ser Ser Leu Gln Leu 
1               5           


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V84 H01

<400>  147

Gly Ala Ser Ser Leu Gln Asn 
1               5           


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID V40 D05

<400>  148

Gln Gln Ala Asp Arg Phe Pro Arg Thr 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID V24 C01

<400>  149

Gln Gln Ala Asp Ser Phe Pro His Thr 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID V48 E01

<400>  150

Gln Gln Ala Asp Ser Leu Pro Arg Thr 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID V49 E02 V73 G02

<400>  151

Gln Gln Ala Asp Ser Tyr Pro Arg Thr 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID V60 F01

<400>  152

Gly Gln Ala Asp Ser Phe Pro Arg Thr 
1               5                   


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V3

<400>  153

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Arg Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Arg Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  154
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V24 C01

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Lys Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  155
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V27 C04

<400>  155

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  156
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V40 D05

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Leu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Arg Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  157
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V48 E01

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  158
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V49 E02 V73 G02

<400>  158

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Arg Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  159
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V52 E05

<400>  159

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Arg Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  160
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V60 F01

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gly Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  161
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V76 G05

<400>  161

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Lys Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  162
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V84 H01

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  163
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/CDRH1 border
 Antibody ID 6E7

<400>  163

Tyr Ser Phe Thr 
1               


<210>  164
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable Region Amino Acid Sequences for Reduced 
       Affinity TREM2 Antibodies - FR1/CDRH1 border

<400>  164

Tyr Ser Phe Ala 
1               


<210>  165
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/CDRH1 border
 Antibody ID V3 A04

<400>  165

Tyr Ser Phe Gly 
1               


<210>  166
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/CDRH1 border
 Antibody ID V49 E02

<400>  166

Tyr Ser Phe Asn 
1               


<210>  167
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/CDRH1 border
 Antibody ID V52 E05

<400>  167

Tyr Ser Phe Glu 
1               


<210>  168
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/CDRH1 border
 Antibody ID V60 F01

<400>  168

Tyr His Phe Thr 
1               


<210>  169
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/CDRH1 border
 Antibody ID V76 G05 V84 H01

<400>  169

Tyr Gly Phe Thr 
1               


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID 6E7 V3 A04

<400>  170

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  171
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID V24 C01

<400>  171

Ile Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  172
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID V27 C04

<400>  172

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID V49 E02

<400>  173

Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Leu Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID V73 G02

<400>  174

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Gly Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID V76 G05

<400>  175

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  176
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V3 A04

<400>  176

Gly Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  177
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V24 C01

<400>  177

Ser Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  178
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V60 F01

<400>  178

Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Ser Asp Tyr 
1               5                   10                  


<210>  179
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V48 E01

<400>  179

Met Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  180
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V3 A04

<400>  180

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ala Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  181
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V24 C01

<400>  181

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  182
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V27 C04

<400>  182

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Val Arg Ser Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  183
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V40 D05

<400>  183

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Gly Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Ser Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  184
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V48 E01

<400>  184

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Gly Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  185
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable Region Amino Acid Sequences for Improved 
       Affinity TREM2 Antibodies - VH Amino Acid Sequence

<400>  185

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asn Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Leu Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  186
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V49 E02

<400>  186

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Glu Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  187
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V60 F01

<400>  187

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr His Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Ser Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  188
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V73 G02

<400>  188

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Gly Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Gly Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  189
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V76 G05

<400>  189

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Gly Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Glu Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Ser Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  190
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V84 H01

<400>  190

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Ser Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  191
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  191

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  192
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  192

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  193
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  193

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  194
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  194

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  195
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  195

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  196
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  196

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  197
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  197

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  198
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  198

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  199
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  199

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  200
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  200

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  201
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  201

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  202
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  202

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  203
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  203

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  204
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  204

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  205
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  205

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  206
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  206

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  207
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  207

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
            100                 105                 110 


<210>  208
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       12G10

<400>  208
caggctgtgc cgactcagcc gtcttccctc tctgcatctc ctggagtatt agccagtctc       60

acctgcacct tacgcagtgg catcaatgtt ggtacctaca ggatatactg gtaccagcag      120

aagccaggga gtcctcccca gtatctcctg aggtacaaat cagactcaga taagcagcag      180

ggctctggag tccccagccg cttctctgga tccaaggatg cttcggccaa tgcagggatt      240

ttactcatct ctgggctcca gtctgaggat gaggctgact attactgtat gatttggtac      300

agcagtgctg tggtattcgg cggagggacc aaactgaccg tccta                      345


<210>  209
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       26A10

<400>  209
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt gggagataag tatgtttgct ggtatcagca gaagccaggc      120

cagtcccctg tgctggtcat ctatcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagtaaca ctgtggtatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  210
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV  Antibody 
       ID 26C10

<400>  210
tcctttgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt gggggataag tatgtttgct ggtatcagca gaagccaggc      120

cagtccccta tgttggtcat ctatcaagat accaagcggc cctcagggat ccctgaacga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtctt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  211
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       26F2

<400>  211
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt gggggataag tatgtttgct ggtatcagca gaagccaggc      120

cagtcccctg tgttggtcat ctttcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  212
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       33B12

<400>  212
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt gggggataag tatgtttgct ggtatcagca gaagccaggc      120

cagtcccctg tgttggtcat ctatcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagtagca ctgtggtatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  213
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       24C12

<400>  213
ggcatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagccg gagtgttttg tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aaggtgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttataact gtcagcaata ttatattact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  214
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       24G6

<400>  214

Gly Ala Cys Ala Thr Cys Gly Thr Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Gly Ala Cys Thr Cys Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Thr Gly Thr Gly Thr Cys Thr Cys Thr Gly Gly Gly Cys 
        35                  40                  45              


Gly Ala Gly Ala Gly Gly Gly Cys Cys Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Ala Cys Thr Gly Cys Ala Ala Gly Thr Cys Cys Ala Gly Cys Cys Ala 
65                  70                  75                  80  


Gly Ala Gly Thr Gly Thr Thr Thr Thr Ala Thr Ala Cys Ala Gly Cys 
                85                  90                  95      


Thr Cys Cys Ala Ala Cys Ala Ala Thr Ala Ala Gly Cys Ala Cys Thr 
            100                 105                 110         


Thr Cys Thr Thr Ala Gly Cys Thr Thr Gly Gly Thr Ala Cys Cys Ala 
        115                 120                 125             


Gly Cys Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Ala Cys Ala Gly 
    130                 135                 140                 


Cys Cys Thr Cys Cys Thr Ala Ala Gly Cys Thr Gly Cys Thr Cys Ala 
145                 150                 155                 160 


Thr Thr Thr Ala Cys Thr Gly Gly Gly Cys Ala Thr Cys Thr Ala Cys 
                165                 170                 175     


Cys Cys Gly Gly Gly Ala Gly Thr Cys Cys Gly Gly Gly Gly Thr Cys 
            180                 185                 190         


Cys Cys Thr Gly Ala Cys Cys Gly Ala Thr Thr Cys Ala Gly Thr Gly 
        195                 200                 205             


Gly Cys Ala Gly Cys Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys 
    210                 215                 220                 


Ala Gly Ala Thr Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys 
225                 230                 235                 240 


Ala Thr Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Gly 
                245                 250                 255     


Cys Thr Gly Ala Ala Gly Ala Thr Gly Thr Gly Gly Cys Ala Thr Thr 
            260                 265                 270         


Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Gly Cys Ala Ala 
        275                 280                 285             


Thr Ala Thr Thr Ala Thr Ala Gly Thr Ala Cys Thr Cys Cys Gly Cys 
    290                 295                 300                 


Thr Cys Ala Cys Thr Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly 
305                 310                 315                 320 


Gly Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Gly Ala Thr Cys 
                325                 330                 335     


Ala Ala Ala 
            


<210>  215
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody 
       24A10

<400>  215
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcacctgca agtccagcca caatgtttta tacagctcca acaataagaa ctacttagct      120

tggtatcagc agaaaccagg acagcctcct aaactgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcaccaata ttatagtact      300

ccgtgcagtt ttggccaggg gaccaagctg gagatcaaa                             339


<210>  216
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       10E3

<400>  216
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggttcca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcttccacca gggccactgg tattccagcc      180

aggttcagtg tcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cattttatta ctgtctgcag gataataatt ggcctcccac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  217
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       13E7

<400>  217
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggttcca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcttccacca gggccactgg tattccagcc      180

aggttcagtg tcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtctgcag gataataatt ggcctcccac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  218
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       25F12

<400>  218
gaaaaagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctcggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  219
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       32E3

<400>  219
gaatttgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccggggga aagagccacc       60

ctctcctgca gggccagtca gattattagc agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat agtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtttgata gctcaccgat caccttcggc      300

cgagggacac gactggacat taaa                                             324


<210>  220
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       24F4

<400>  220
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcactgta ttactgtcag cagtatgata cctcaccatt cactttcggc      300

cctgggacca aagtggatat caaa                                             324


<210>  221
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       16B8

<400>  221
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

gtcacttgtc gggcgagtca ggatattaac agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatcctctt tgcaaactgg ggtcccttca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactc ttgtcaacag tctaacagtt tcccgatcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210>  222
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       4C5

<400>  222
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc aactggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaagttgg ggtcccatta      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctgacagtt tccctcgcaa ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  223
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       6E7 V9 A10 V30 C07 V33 C10 V44 D09 V68 F09

<400>  223
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  224
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV - Antibody 
       ID 5E3

<400>  224
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca      120

gggaaagccc ctaaatccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tatagtactt acccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  225
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       4G10

<400>  225
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcataaga aatgatttag gctggtatca gcagaaacca      120

gggaatgccc ctaagcgcct gatctatgct gcatccagtt tgccaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggccagaa ttcactctca caatcagcag tctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa      300

gggaccaagg tggaaatcac a                                                321


<210>  226
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V3 A04

<400>  226
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagta ggcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacaggt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  227
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V24 C01

<400>  227
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaaggg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcatac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  228
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V27

<400>  228
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaacgtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  229
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V40 D05

<400>  229
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaacttgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgaccgtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  230
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V48 E01

<400>  230
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaacggg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tgcctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  231
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V49 E02

<400>  231
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtc ggcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt atcctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  232
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V52 E05

<400>  232
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagggg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgaccgtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  233
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V60 F01

<400>  233
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagggg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtgggcag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  234
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V73 G02

<400>  234
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtc gtcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt atcctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  235
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V76 G05

<400>  235
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaaggg ggtcccatca      180

aggttcagcg gcagtggatc tgggagagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  236
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V84 H01

<400>  236
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tcccgcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  237
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       12G10

24C12

<400>  237
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attggtggtg gtggtgttag cacatactgc      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaattttat      300

atagcagtgg ctggttctca ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  238
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       26A10

<400>  238
gaggtgcaac tggtggagtc tgggggagcc ttggtacagc ggggggggtc cctgagactc       60

tcctgtgcag cctctagatt caccttcagt agctttggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtagttttac catatattac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ttcattctat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt attactgtgc gagagagggg      300

ggtcttacta tggttcgggg agtctcttcc tacggtttgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  239
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV 26C10

<400>  239
gaggtgcaac tggtggagtc tgggggagcc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctttggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtagttttac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ttcgttctat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt atttctgtgt gagagagggg      300

ggtataacta tggttcgggg agtctcttcc tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  240
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       26F2

<400>  240
gaggtgcaac tggtggagtc tgggggagcc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctttggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatttcatac attagtagta gtagttttac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ttcattctat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt atttctgtgc gagagagggg      300

ggtattacta tggttcgggg agtctcttcc tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  241
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       33B12

<400>  241
gaggtgcaac tggtggagtc tgggggagcc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctttggca tgagctgggt ccgccaggct      120

ccagggaagg gcctggagtg ggtttcatac attagtaaaa gtagttttac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ttcattctat      240

ctgcaaatga acagcctgag agacgaggac acggctgtgt attactgtgc gagagagggg      300

ggtcttacta tggttcgggg agtctcttcc tacggtttgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  242
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       24G6

<400>  242
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg gactggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaggcgtat      300

acacctatgg cattctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  243
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       24A10

<400>  243
gaggtgcagg tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggaggg      300

tgggagctat tttactgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  244
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       10E3

<400>  244
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgatgatc       60

tcctgtaagg gttctggata cagctttacc aactactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gagactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacggaga      300

caggggatct ggggtgatgc tcttgatatc tggggccaag ggacattggt caccgtctct      360

tca                                                                    363


<210>  245
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       13E7

<400>  245
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgatgatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gagactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacggaga      300

caggggatct ggggtgatgc tcttgatttc tggggccaag ggacattggt caccgtctct      360

tca                                                                    363


<210>  246
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       25F12


<220>
<221>  misc_feature
<222>  (366)..(366)
<223>  n is a, c, g, or t

<400>  246
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt agttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaaacac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agaggggtat      300

tacgatatct tgactggtta tcatgatgct tttgatattt gggaccaagg gacaatggtc      360

accgtntttt ca                                                          372


<210>  247
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       32E3

<400>  247
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcaccctgaa ggcctcggac accgccatat attactgtgc gcgacatgac      300

attataccag cagcccctgg tgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  248
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       24F4

<400>  248
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cacctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagtcgaca agtccagcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatat attactgtac gagacaggcc      300

atagcagtga ctggtttggg gggtttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  249
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       16B8

<400>  249
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc aactatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag tacagtctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagacgggga      300

tacagctatg gttcctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  250
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       4C5

<400>  250
gaggtgcagc tggtgcagtc tggagcagaa gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggaca cagttttacc aactactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccgtgt atttctgtgc gagacaaagg      300

acgttttact atgatagtag tggttatttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  251
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       6E7

<400>  251
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  252
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       5E3

<400>  252
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tacactgggt gcgacaggcc      120

cctggactag ggcttgagtg gatgggatgg atcaaccctt acagtggtgg cacaacctct      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag ctcagcctac      240

atggaactga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatgga      300

ggctacctgg ccctctacgg tacggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  253
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       4G10

<400>  253
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttccc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgccttt      240

ttgaagtgga gtagcctgaa ggcctcggac accgccatgt atttctgtgc gcgacagggt      300

atagaagtga ctggtacggg aggtttggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  254
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V3 A04

<400>  254
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttgcg agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaagatca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagagggagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  255
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V24 C01

<400>  255
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga ttgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgtgagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagatctagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  256
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V27 C04

<400>  256
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

gctccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgt gagaagtagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  257
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V40 D05

<400>  257
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttggg agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgttagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattattcg gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  258
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V48 E01

<400>  258
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttggt agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgtgagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagaatgagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  259
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V49 E02

<400>  259
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttaat agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggacg atctatcctg gtgactctga taccagactg      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagaagtagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  260
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V52 E05

<400>  260
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttgag agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagagggagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  261
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V60 F01

<400>  261
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata ccattttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgtgagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatagt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  262
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V73 G02

<400>  262
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttggt agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccggggt tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagagggagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  263
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V76 G05

<400>  263
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttggg agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccggagt tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatagt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  264
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V84 H01

<400>  264
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cgggtttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgacagtga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattattcg gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  265
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #1

<400>  265

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  266
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #2

<400>  266

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  267

<400>  267
000

<210>  268
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #4

<400>  268

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  269
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #5

<400>  269

Met Glu Trp Thr Trp Arg Val Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  270
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #6

<400>  270

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  271
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Antibody ID V83

<400>  271

Gln Gln Ala Val Ser Phe Pro Arg Thr 
1               5                   


<210>  272
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #8

<400>  272

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  273
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #9

<400>  273

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  274
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #10

<400>  274

Met Asp Ile Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys 
            20          


<210>  275
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #11

<400>  275

Met Asp Ile Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  276
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #12

<400>  276

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe 
            20          


<210>  277
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #13

<400>  277

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  278
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #14

<400>  278

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  279
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #15

<400>  279

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Glu 
            20      


<210>  280
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretory peptide #16

<400>  280

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  281
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  281

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  282
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  282

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
    50                  55                  60                  


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  283
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG peptide 35-55

<400>  283

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  284
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Consensus for 6E7 reduced Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is R OR A

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X IS S OR R

<400>  284

Xaa Ala Ser Gln Gly Ile Ser Xaa Trp Leu Ala 
1               5                   10      


<210>  285
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Consensus for 6E7 reduced Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is S or G

<400>  285

Xaa Ala Xaa Ser Leu Gln Asn 
1               5           


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 Consensus for 6E7 reduced Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is D or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is R or L

<400>  286

Gln Gln Ala Xaa Ser Phe Pro Xaa Thr 
1               5                   


<210>  287
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Consensus for 6E7 reduced Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Y or E

<400>  287

Ser Xaa Trp Ile Ala 
1               5   


<210>  288
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Consensus for 6E7 reduced Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is G or S

<400>  288

Ile Ile Tyr Pro Xaa Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  289
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Consensus for 6E7 reduced Affinity variants


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Y or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y or G

<400>  289

Gln Arg Xaa Phe Xaa Xaa Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  290
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID V57 E10

<400>  290

Ala Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  291
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 Antibody ID V90 H07

<400>  291

Arg Ala Ser Gln Gly Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  292
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V10 A11

<400>  292

Ser Ala Ser Ser Leu Gln Asn 
1               5           


<210>  293
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V70 F11

<400>  293

Ala Ala Gly Ser Leu Gln Asn 
1               5           


<210>  294
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 Antibody ID V23 B12

<400>  294

Gln Gln Ala Asp Ser Phe Pro Leu Thr 
1               5                   


<210>  295
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V10 A11

<400>  295

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  296
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V23 B12

<400>  296

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  297
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V57 E10

<400>  297

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ala Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  298
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V70 F11

<400>  298

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  299
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V83 G12

<400>  299

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Val Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  300
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Amino Acid Sequence Antibody ID V90 H07

<400>  300

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  301
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1/
CDRH1 border
 Antibody ID V30 C07

<400>  301

Ser Ser Phe Thr 
1               


<210>  302
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 Antibody ID V90 H07

<400>  302

Ser Glu Trp Ile Ala 
1               5   


<210>  303
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 Antibody ID V44 D09

<400>  303

Ile Ile Tyr Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  304
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V9 A10

<400>  304

Gln Arg Gly Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  305
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V33 C10

<400>  305

Gln Arg Thr Phe Tyr Gly Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  306
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 Antibody ID V68 F09

<400>  306

Gln Arg Thr Phe Arg Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   10                  


<210>  307
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V9 A10

<400>  307

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Gly Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  308
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V30 C07

<400>  308

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Ser Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  309
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V33 C10

<400>  309

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Gly Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  310
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V44 D09

<400>  310

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  311
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V68 F09

<400>  311

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Arg Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  312
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Amino Acid Sequence Antibody ID V90 H07

<400>  312

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Glu 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  313
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V10 A11

<400>  313
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  314
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V23 B12

<400>  314
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcttac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  315
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V57 E10

<400>  315
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtg cggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  316
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V70 F11

<400>  316
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcagggagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  317
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V83

<400>  317
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgtgagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  318
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - LV Antibody ID
       V90 H07

<400>  318
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agatggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacagtt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  319
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V9 A10

<400>  319
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

gggttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  320
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V10 A11

V23 B12 V57 E10 V70 F11 V83 G12

<400>  320
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  321
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V30 C07

<400>  321
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggatc gagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  322
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V33 C10

<400>  322
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatg gggatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  323
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V44 D09

<400>  323
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatccta gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  324
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V68 F09

<400>  324
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgtttaggt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  325
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-TREM2 Antibody Variable Region Nucleic Acid - HV Antibody ID
       V90 H07

<400>  325
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agcgagtgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  326
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence 24G6

<400>  326

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys His Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  327
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence 24G6

<400>  327

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Tyr Thr Pro Met Ala Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  328
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence 6E7

<400>  328

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asp Ala Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  329
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence 6E7

<400>  329

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ala Asp Ala Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Arg Thr Phe Tyr Tyr Asp Ser Ser Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  330
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence 13E7

<400>  330

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Asp Asn Asn Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  331
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence 13E7

<400>  331

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ala Asp Ala Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Arg Gln Gly Ile Phe Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  332
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence 5E3

<400>  332

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  333
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence 5E3

<400>  333

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Ser Gly Gly Thr Thr Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Gly Tyr Leu Ala Leu Tyr Gly Thr Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  334
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence LC SST28347

<400>  334

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys His Phe Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala 
            100                 105                 110         


Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
    130                 135                 140                 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
145                 150                 155                 160 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
                165                 170                 175     


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
            180                 185                 190         


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
        195                 200                 205             


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
    210                 215                 220                 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
225                 230                 235                 240 


Glu Cys 
        


<210>  335
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence HC SST28347

<400>  335

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ala Tyr Thr Pro Met Ala Phe Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
305                 310                 315                 320 


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  336
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence HC SST204812

<400>  336

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Ala Tyr Thr Pro Met Ala Phe Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr 
305                 310                 315                 320 


Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  337
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence SST29857

<400>  337

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Ala Asp Ala Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  338
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence LC SST29857

<400>  338

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Val Ser Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Asp Asn Asn Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  339
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence LC SST202443

<400>  339

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Val Ser Ser Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Asp Asn Asn Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  340
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence HC SST202443

<400>  340

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        35                  40                  45              


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ala Asp Ala 
65                  70                  75                  80  


Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
            100                 105                 110         


Thr Ala Met Tyr Phe Cys Ala Arg Arg Arg Gln Gly Ile Phe Gly Asp 
        115                 120                 125             


Ala Leu Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
305                 310                 315                 320 


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  341
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence LC SST29825

<400>  341

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Ser Thr Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  342
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA sequence HC SST29825

<400>  342

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Tyr Ser Gly Gly Thr 
65                  70                  75                  80  


Thr Ser Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Ser Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ala Gly Tyr Leu Ala Leu Tyr 
        115                 120                 125             


Gly Thr Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
305                 310                 315                 320 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  343
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence SST28347 and SST204812

<400>  343
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagca cttcttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gagtccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

ccgctcactt tcggcggagg gaccaaggtg gagatcaaa                             339


<210>  344
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence SST28347 and SST204812

<400>  344
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg gactggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagaatccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaggcgtat      300

acacctatgg cattctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  345
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence SST29857

<400>  345
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttactt ttgtcaacag gctgacgctt tccctcgcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  346
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence SST29857

<400>  346
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgacgctga tgccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctacagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagacaaagg      300

acgttttatt atgatagtag tgattatttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369


<210>  347
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence SST202443

<400>  347
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggttcca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcttccacca gggccactgg tattccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gaagattttg cagtttatta ctgtctgcag gataataatt tccctcccac tttcggccaa      300

gggaccaaag tggatatcaa a                                                321


<210>  348
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence SST202443

<400>  348
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gagatgctga tgccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gaggcggaga      300

caggggatct tcggtgatgc tcttgatttc tggggccaag ggacattggt caccgtgtct      360

tca                                                                    363


<210>  349
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC variable region sequence SST29825

<400>  349
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagccc ctaaatccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tatagtactt acccattcac tttcggccaa      300

gggaccaaag tggatatcaa a                                                321


<210>  350
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC variable region sequence SST29825

<400>  350
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtg       60

tcctgcaagg cttctggata caccttcacc ggctactata tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctt acagtggtgg cacaacctct      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccaccag ctcagcctac      240

atggaactga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatgca      300

ggctacctgg ccctctacgg tacggacgtc tggggccaag ggaccttggt caccgtgtcc      360

tca                                                                    363


<210>  351
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence LC SST28347

<400>  351
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tcgtgatgac ccagtctcca gactccctgg ctgtgtctct gggcgagagg      120

gccaccatca actgcaagtc cagccagagt gttttataca gctccaacaa taagcacttc      180

ttagcttggt accagcagaa accaggacag cctcctaagc tgctcattta ctgggcatct      240

acccgggagt ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact      300

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat      360

agtactccgc tcactttcgg cggagggacc aaggtggaga tcaaacgaac ggtggctgca      420

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt      480

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac      540

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc      600

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac      660

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga      720

gagtgt                                                                 726


<210>  352
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence HC SST28347

<400>  352
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      180

caggctccag ggaagggact ggagtgggtc tcagctatta gtggtagtgg tggtagcaca      240

tactacgcag aatccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaag      360

gcgtatacac ctatggcatt ctttgactac tggggccagg gaaccctggt caccgtctcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgtgcga ggagcagtac      960

ggcagcacgt accgttgcgt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt gtccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggc aaa                                  1413


<210>  353
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence HC SST204812

<400>  353
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      180

caggctccag ggaagggact ggagtgggtg tcagctatta gtggtagtgg tggtagcaca      240

tactacgcag aatccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaag      360

gcgtatacac ctatggcatt ctttgactac tggggccagg gaaccctggt caccgtgtcc      420

tcagcctcca ccaagggccc atcggtcttc cccctggcgc ccagctccag gagcacctcc      480

gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      720

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgtgcg aggagcagta cggcagcacg      960

taccgttgcg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tgtccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg caaa                                            1404


<210>  354
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence LC SST29857

<400>  354
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagtctcca tcttccgtgt ctgcatctgt aggagacaga      120

gtcaccatca cttgtcgggc gagtcagggt attagcagct ggttagcctg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccatcaaggt tcagcggcag tggatctggg acagatttca ctctcaccat cagcagcctg      300

cagcctgaag attttgcaac ttacttttgt caacaggctg acgctttccc tcgcactttt      360

ggccagggga ccaagctgga gatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  355
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence HC SST29857

<400>  355
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg ggagtctctg      120

aagatctcct gtaagggttc tggatacagt tttaccagct actggatcgc ctgggtgcgc      180

cagatgcccg ggaaaggcct ggagtggatg gggatcatct atcctggtga cgctgatgcc      240

agatacagcc cgtccttcca aggccaggtc accatctcag ccgacaagtc catcagcacc      300

gcctacctac agtggagcag cctgaaggcc tcggacaccg ccatgtattt ctgtgcgaga      360

caaaggacgt tttattatga tagtagtgat tattttgact actggggcca gggaaccctg      420

gtcaccgtgt cctcagcctc caccaagggc ccatcggtct tccccctggc gcccagctcc      480

aggagcacct ccgagagcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgct ctgaccagcg gcgtgcacac cttcccagct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcaac      660

ttcggcaccc agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac      720

aagacagttg agcgcaaatg ttgtgtcgag tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgtg cgaggagcag      960

tacggcagca cgtaccgttg cgtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtgtccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggcaaa                               1416


<210>  356
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence LC SST202443

<400>  356
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaaa tagtgatgac gcagtctcca gccaccctgt ctgtgtctcc aggggaaaga      120

gccaccctct cctgcagggc cagtcagagt gttagcagca acttagcctg gttccagcag      180

aaacctggcc aggctcccag gctcctcatc tatggtgctt ccaccagggc cactggtatt      240

ccagccaggt tcagtggcag tgggtctggg acagagttca ctctcaccat cagcagcctg      300

cagcctgaag attttgcagt ttattactgt ctgcaggata ataatttccc tcccactttc      360

ggccaaggga ccaaagtgga tatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  357
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence HC SST202443

<400>  357
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg ggagtctctg      120

aagatctcct gtaagggttc tggatacagc tttaccagct actggatcgg ctgggtgcgc      180

cagatgcccg ggaaaggcct ggagtggatg gggatcatct atcctggaga tgctgatgcc      240

agatacagcc cgtccttcca aggccaggtc accatctcag ccgacaagtc catcagcacc      300

gcctacctgc agtggagcag cctgaaggcc tcggacaccg ccatgtattt ctgtgcgagg      360

cggagacagg ggatcttcgg tgatgctctt gatttctggg gccaagggac attggtcacc      420

gtgtcttcag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      480

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      780

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gtgcgaggag      960

cagtacggca gcacgtaccg ttgcgtcagc gtcctcaccg tcctgcacca ggactggctg     1020

aatggcaagg agtacaagtg caaggtgtcc aacaaagccc tcccagcccc catcgagaaa     1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1140

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1260

cctcccgtgc tggactccga cggctccttc ttcctctata gcaagctcac cgtggacaag     1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1380

cactacacgc agaagagcct ctccctgtct ccgggcaaa                            1419


<210>  358
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence LC SST29825

<400>  358
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaca tccagatgac ccagtctcca tcctcactgt ctgcatctgt aggagacaga      120

gtcaccatca cttgtcgggc gagtcagggc attagcaatt atttagcctg gtatcagcag      180

aaaccaggga aagcccctaa atccctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccatcaaggt tcagcggcag tggatctggg acagatttca ctctcaccat cagcagcctg      300

cagcctgaag attttgcaac ttattactgc caacagtata gtacttaccc attcactttc      360

ggccaaggga ccaaagtgga tatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  359
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence HC SST29825

<400>  359
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtgtcct gcaaggcttc tggatacacc ttcaccggct actatatcca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca acccttacag tggtggcaca      240

acctctgcac agaagtttca gggcagggtc accatgacca gggacacgtc caccagctca      300

gcctacatgg aactgagcag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatgcaggct acctggccct ctacggtacg gacgtctggg gccaagggac cttggtcacc      420

gtgtcctcag cctccaccaa gggcccatcg gtcttccccc tggcgcccag ctccaggagc      480

acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      540

acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta      600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag caacttcggc      660

acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca      720

gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag cacctgaact cctgggggga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgtgcgagga gcagtacggc      960

agcacgtacc gttgcgtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtgtc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggcaaa                                      1410


<210>  360
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  360

His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
1               5                   10  


<210>  361
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  361

Ala Gly Asp Leu Trp Phe Pro Gly Glu 
1               5                   


<210>  362
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  362

Gly Asp Leu Trp Phe Pro Gly Glu Ser Glu 
1               5                   10  


<210>  363
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  363

His Arg Asp Ala Gly Asp Leu Trp Phe Pro Gly Glu Ser Glu 
1               5                   10                  


<210>  364
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  364

Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro Gly Glu Ser 
1               5                   10                  15      


Glu 
    


<210>  365
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  365

Pro Leu Asp His Arg Asp Ala Gly Asp Ala Trp Phe Pro Gly Glu Ser 
1               5                   10                  15      


Glu 
    


<210>  366
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  366

Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Ala Pro Gly Glu Ser 
1               5                   10                  15      


Glu 
    


<210>  367
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptides from epitope mapping experiments

<400>  367

Gly Asp Leu Trp Phe Pro 
1               5       


